                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Powell, Daniel
 
<120>  COMPOSITIONS AND METHODS OF NKG2D CHIMERIC ANTIGEN RECEPTOR T CELLS FOR CONTROLLING TRIPLE-NEGATIVE BREAST CANCER

<130>  046483-7218WO1(02038)

<150>  U.S. Provisional Patent Application No. 62/689,552
<151>  2018-06-25

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  9663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector: PELNS_eGFP_2A_NKG2D_CD27_CD3Zeta

<400>  1
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcggcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg      840

ccgccaggcc gggatccttc aaccaagaag ttcaaattcc cttgaccgaa agttactgtg      900

gcccatgtcc taaaaactgg atatgttaca aaaataactg ctaccaattt tttgatgaga      960

gtaaaaactg gtatgagagc caggcttctt gtatgtctca aaatgccagc cttctgaaag     1020

tatacagcaa agaggaccag gatttactta aactggtgaa gtcatatcat tggatgggac     1080

tagtacacat tccaacaaat ggatcttggc agtgggaaga tggctccatt ctctcaccca     1140

acctactaac aataattgaa atgcagaagg gagactgtgc actctatgcc tcgagcttta     1200

aaggctatat agaaaactgt tcaactccaa atacgtacat ctgcatgcaa aggactgtgg     1260

ctagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc     1320

ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg     1380

ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact tgtggggtcc     1440

ttctcctgtc actggttatc accctttact gccaacgaag gaaatataga tcaaacaaag     1500

gagaaagtcc tgtggagcct gcagagcctt gtcgttacag ctgccccagg gaggaggagg     1560

gcagcaccat ccccatccag gaggattacc gaaaaccgga gcctgcctgc tcccccagag     1620

tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac cagctctata     1680

acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga cgtggccggg     1740

accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg tacaatgaac     1800

tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga     1860

ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg     1920

acgcccttca catgcaggcc ctgccccctc gctaagtcga caatcaacct ctggattaca     1980

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     2040

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     2100

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     2160

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     2220

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     2280

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     2340

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     2400

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     2460

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     2520

gtcggatctc cctttgggcc gcctccccgc ctggaattcg agctcggtac ctttaagacc     2580

aatgacttac aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga     2640

agggctaatt cactcccaac gaagacaaga tctgcttttt gcttgtactg ggtctctctg     2700

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc     2760

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg     2820

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtagtagttc     2880

atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag     2940

gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac     3000

aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc     3060

ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccagttccgc ccattctccg     3120

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag     3180

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcgt cgagacgtac     3240

ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc     3300

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     3360

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     3420

tgaatggcga atggcgcgac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     3480

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     3540

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     3600

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg     3660

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     3720

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     3780

tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc     3840

tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca atttcccagg     3900

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc     3960

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     4020

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg     4080

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt     4140

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt     4200

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt     4260

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa     4320

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag     4380

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac     4440

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac     4500

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac     4560

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac     4620

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact     4680

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg     4740

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt     4800

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat     4860

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta     4920

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa     4980

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     5040

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     5100

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     5160

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc     5220

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     5280

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     5340

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     5400

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     5460

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     5520

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     5580

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     5640

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     5700

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga     5760

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga     5820

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     5880

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     5940

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt     6000

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc     6060

caagcgcgca attaaccctc actaaaggga acaaaagctg gagctgcaag cttaatgtag     6120

tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca acatgcctta     6180

caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta cgatcgtgcc     6240

ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga attgccgcat     6300

tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgggtctc tctggttaga     6360

ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata     6420

aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta     6480

gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg     6540

gacctgaaag cgaaagggaa accagagctc tctcgacgca ggactcggct tgctgaagcg     6600

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     6660

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     6720

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     6780

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     6840

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     6900

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     6960

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     7020

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     7080

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     7140

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     7200

tgggttcttg ggagcagcag gaagcactat gggcgcagcc tcaatgacgc tgacggtaca     7260

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     7320

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     7380

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     7440

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     7500

acagattgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc     7560

ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta     7620

ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg     7680

tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct     7740

gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt tcagacccac     7800

ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg tggagagaga     7860

gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgatt agactgtagc     7920

ccaggaatat ggcagctaga ttgtacacat ttagaaggaa aagttatctt ggtagcagtt     7980

catgtagcca gtggatatat agaagcagaa gtaattccag cagagacagg gcaagaaaca     8040

gcatacttcc tcttaaaatt agcaggaaga tggccagtaa aaacagtaca tacagacaat     8100

ggcagcaatt tcaccagtac tacagttaag gccgcctgtt ggtgggcggg gatcaagcag     8160

gaatttggca ttccctacaa tccccaaagt caaggagtaa tagaatctat gaataaagaa     8220

ttaaagaaaa ttataggaca ggtaagagat caggctgaac atcttaagac agcagtacaa     8280

atggcagtat tcatccacaa ttttaaaaga aaagggggga ttggggggta cagtgcaggg     8340

gaaagaatag tagacataat agcaacagac atacaaacta aagaattaca aaaacaaatt     8400

acaaaaattc aaaattttcg ggtttattac agggacagca gagatccagt ttggctgcat     8460

acgcgtcgtg aggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg     8520

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa     8580

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt     8640

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac     8700

aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt tacgggttat ggcccttgcg     8760

tgccttgaat tacttccacc tggctgcagt acgtgattct tgatcccgag cttcgggttg     8820

gaagtgggtg ggagagttcg aggccttgcg cttaaggagc cccttcgcct cgtgcttgag     8880

ttgaggcctg gcctgggcgc tggggccgcc gcgtgcgaat ctggtggcac cttcgcgcct     8940

gtctcgctgc tttcgataag tctctagcca tttaaaattt ttgatgacct gctgcgacgc     9000

tttttttctg gcaagatagt cttgtaaatg cgggccaaga tctgcacact ggtatttcgg     9060

tttttggggc cgcgggcggc gacggggccc gtgcgtccca gcgcacatgt tcggcgaggc     9120

ggggcctgcg agcgcggcca ccgagaatcg gacgggggta gtctcaagct ggccggcctg     9180

ctctggtgcc tggcctcgcg ccgccgtgta tcgccccgcc ctgggcggca aggctggccc     9240

ggtcggcacc agttgcgtga gcggaaagat ggccgcttcc cggccctgct gcagggagct     9300

caaaatggag gacgcggcgc tcgggagagc gggcgggtga gtcacccaca caaaggaaaa     9360

gggcctttcc gtcctcagcc gtcgcttcat gtgactccac ggagtaccgg gcgccgtcca     9420

ggcacctcga ttagttctcg agcttttgga gtacgtcgtc tttaggttgg ggggaggggt     9480

tttatgcgat ggagtttccc cacactgagt gggtggagac tgaagttagg ccagcttggc     9540

acttgatgta attctccttg gaatttgccc tttttgagtt tggatcttgg ttcattctca     9600

agcctcagac agtggttcaa agtttttttc ttccatttca ggtgtcgtga gctagctcta     9660

gag                                                                   9663


<210>  2
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  2
ttcaaccaag aagttcaaat tcccttgacc gaaagttact gtggcccatg tcctaaaaac       60

tggatatgtt acaaaaataa ctgctaccaa ttttttgatg agagtaaaaa ctggtatgag      120

agccaggctt cttgtatgtc tcaaaatgcc agccttctga aagtatacag caaagaggac      180

caggatttac ttaaactggt gaagtcatat cattggatgg gactagtaca cattccaaca      240

aatggatctt ggcagtggga agatggctcc attctctcac ccaacctact aacaataatt      300

gaaatgcaga agggagactg tgcactctat gcctcgagct ttaaaggcta tatagaaaac      360

tgttcaactc caaatacgta catctgcatg caaaggactg tg                         402


<210>  3
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
1               5                   10                  15      


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
            20                  25                  30          


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
        35                  40                  45              


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
    50                  55                  60                  


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
65                  70                  75                  80  


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
                85                  90                  95      


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
            100                 105                 110         


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
        115                 120                 125             


Cys Met Gln Arg Thr Val 
    130                 


<210>  4
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD27

<400>  4
caacgaagga aatatagatc aaacaaagga gaaagtcctg tggagcctgc agagccttgt       60

cgttacagct gccccaggga ggaggagggc agcaccatcc ccatccagga ggattaccga      120

aaaccggagc ctgcctgctc cccc                                             144


<210>  5
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27

<400>  5

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  6
<211>  9645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector: PELNS_eGFP_2A_NKG2D_41BB_CD3Zeta

<400>  6
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcggcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg      840

ccgccaggcc gggatccttc aaccaagaag ttcaaattcc cttgaccgaa agttactgtg      900

gcccatgtcc taaaaactgg atatgttaca aaaataactg ctaccaattt tttgatgaga      960

gtaaaaactg gtatgagagc caggcttctt gtatgtctca aaatgccagc cttctgaaag     1020

tatacagcaa agaggaccag gatttactta aactggtgaa gtcatatcat tggatgggac     1080

tagtacacat tccaacaaat ggatcttggc agtgggaaga tggctccatt ctctcaccca     1140

acctactaac aataattgaa atgcagaagg gagactgtgc actctatgcc tcgagcttta     1200

aaggctatat agaaaactgt tcaactccaa atacgtacat ctgcatgcaa aggactgtgg     1260

ctagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc     1320

ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg     1380

ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact tgtggggtcc     1440

ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa ctcctgtata     1500

tattcaaaca accatttatg agaccagtac aaactactca agaggaagat ggctgtagct     1560

gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc agcaggagcg     1620

cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc aatctaggac     1680

gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa     1740

agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1800

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1860

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1920

ccctgccccc tcgctaagtc gacaatcaac ctctggatta caaaatttgt gaaagattga     1980

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     2040

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     2100

tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg     2160

tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg     2220

ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc     2280

gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaagc     2340

tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct     2400

tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg     2460

ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg     2520

ccgcctcccc gcctggaatt cgagctcggt acctttaaga ccaatgactt acaaggcagc     2580

tgtagatctt agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca     2640

acgaagacaa gatctgcttt ttgcttgtac tgggtctctc tggttagacc agatctgagc     2700

ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg     2760

agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag     2820

acccttttag tcagtgtgga aaatctctag cagtagtagt tcatgtcatc ttattattca     2880

gtatttataa cttgcaaaga aatgaatatc agagagtgag aggaacttgt ttattgcagc     2940

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3000

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggctcta     3060

gctatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt     3120

ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga     3180

ggaggctttt ttggaggcct aggcttttgc gtcgagacgt acccaattcg ccctatagtg     3240

agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     3300

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     3360

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcg     3420

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     3480

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     3540

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     3600

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     3660

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     3720

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     3780

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     3840

acgcgaattt taacaaaata ttaacgttta caatttccca ggtggcactt ttcggggaaa     3900

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     3960

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     4020

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     4080

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta     4140

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt     4200

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc     4260

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc     4320

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc     4380

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa     4440

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga     4500

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat     4560

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca     4620

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc     4680

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat     4740

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag     4800

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa     4860

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca     4920

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc     4980

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc     5040

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc     5100

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt     5160

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt     5220

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc     5280

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa     5340

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac     5400

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg     5460

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga     5520

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact     5580

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa     5640

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc     5700

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg     5760

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat     5820

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     5880

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     5940

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     6000

ataacaattt cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc     6060

tcactaaagg gaacaaaagc tggagctgca agcttaatgt agtcttatgc aatactcttg     6120

tagtcttgca acatggtaac gatgagttag caacatgcct tacaaggaga gaaaaagcac     6180

cgtgcatgcc gattggtgga agtaaggtgg tacgatcgtg ccttattagg aaggcaacag     6240

acgggtctga catggattgg acgaaccact gaattgccgc attgcagaga tattgtattt     6300

aagtgcctag ctcgatacaa taaacgggtc tctctggtta gaccagatct gagcctggga     6360

gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct     6420

tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt     6480

ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca gggacctgaa agcgaaaggg     6540

aaaccagagc tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag     6600

gggcggcgac tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat     6660

gggtgcgaga gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg     6720

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag     6780

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata     6840

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat     6900

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct     6960

ttagacaaga tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct     7020

gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata     7080

taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt     7140

gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc     7200

aggaagcact atgggcgcag cctcaatgac gctgacggta caggccagac aattattgtc     7260

tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt     7320

gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata     7380

cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac     7440

tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattg gaatcacacg     7500

acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt     7560

gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg     7620

gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata     7680

atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat     7740

agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga     7800

cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt     7860

cgattagtga acggatctcg acggtatcga ttagactgta gcccaggaat atggcagcta     7920

gattgtacac atttagaagg aaaagttatc ttggtagcag ttcatgtagc cagtggatat     7980

atagaagcag aagtaattcc agcagagaca gggcaagaaa cagcatactt cctcttaaaa     8040

ttagcaggaa gatggccagt aaaaacagta catacagaca atggcagcaa tttcaccagt     8100

actacagtta aggccgcctg ttggtgggcg gggatcaagc aggaatttgg cattccctac     8160

aatccccaaa gtcaaggagt aatagaatct atgaataaag aattaaagaa aattatagga     8220

caggtaagag atcaggctga acatcttaag acagcagtac aaatggcagt attcatccac     8280

aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     8340

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     8400

cgggtttatt acagggacag cagagatcca gtttggctgc atacgcgtcg tgaggctccg     8460

gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg     8520

tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg     8580

tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg     8640

ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg     8700

gttcccgcgg gcctggcctc tttacgggtt atggcccttg cgtgccttga attacttcca     8760

cctggctgca gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt     8820

cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc     8880

gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata     8940

agtctctagc catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata     9000

gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg     9060

gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc     9120

caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg     9180

cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt     9240

gagcggaaag atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc     9300

gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag     9360

ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct     9420

cgagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc     9480

cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct     9540

tggaatttgc cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc     9600

aaagtttttt tcttccattt caggtgtcgt gagctagctc tagag                     9645


<210>  7
<211>  9519
<212>  DNA
<213>  Artificial Sequece

<220>
<223>  Vector: PELNS_eGFP_2A_NKG2D_CD3Zeta

<400>  7
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaga      720

tctggcggcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc      780

ggccctagat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg      840

ccgccaggcc gggatccttc aaccaagaag ttcaaattcc cttgaccgaa agttactgtg      900

gcccatgtcc taaaaactgg atatgttaca aaaataactg ctaccaattt tttgatgaga      960

gtaaaaactg gtatgagagc caggcttctt gtatgtctca aaatgccagc cttctgaaag     1020

tatacagcaa agaggaccag gatttactta aactggtgaa gtcatatcat tggatgggac     1080

tagtacacat tccaacaaat ggatcttggc agtgggaaga tggctccatt ctctcaccca     1140

acctactaac aataattgaa atgcagaagg gagactgtgc actctatgcc tcgagcttta     1200

aaggctatat agaaaactgt tcaactccaa atacgtacat ctgcatgcaa aggactgtgg     1260

ctagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc gcgtcgcggc     1320

ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg     1380

ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact tgtggggtcc     1440

ttctcctgtc actggttatc accctttact gcagagtgaa gttcagcagg agcgcagacg     1500

cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta ggacgaagag     1560

aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg ggaaagccga     1620

gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg     1680

cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt     1740

accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc     1800

cccctcgcta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta     1860

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     1920

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     1980

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     2040

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     2100

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     2160

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt     2220

cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct     2280

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     2340

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     2400

ccccgcctgg aattcgagct cggtaccttt aagaccaatg acttacaagg cagctgtaga     2460

tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag     2520

acaagatctg ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga     2580

gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct     2640

tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt     2700

ttagtcagtg tggaaaatct ctagcagtag tagttcatgt catcttatta ttcagtattt     2760

ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg cagcttataa     2820

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     2880

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc tctagctatc     2940

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     3000

atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc     3060

ttttttggag gcctaggctt ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt     3120

attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta     3180

cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg     3240

cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc     3300

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     3360

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     3420

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     3480

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     3540

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     3600

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     3660

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     3720

attttaacaa aatattaacg tttacaattt cccaggtggc acttttcggg gaaatgtgcg     3780

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     3840

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     3900

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     3960

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     4020

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     4080

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     4140

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     4200

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     4260

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     4320

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     4380

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     4440

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     4500

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     4560

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     4620

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     4680

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     4740

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     4800

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     4860

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     4920

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     4980

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     5040

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     5100

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     5160

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     5220

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     5280

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     5340

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     5400

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     5460

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     5520

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     5580

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     5640

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa     5700

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga     5760

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc     5820

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca     5880

atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta     5940

aagggaacaa aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct     6000

tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca     6060

tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt     6120

ctgacatgga ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc     6180

ctagctcgat acaataaacg ggtctctctg gttagaccag atctgagcct gggagctctc     6240

tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt     6300

agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc     6360

agtgtggaaa atctctagca gtggcgcccg aacagggacc tgaaagcgaa agggaaacca     6420

gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg cgaggggcgg     6480

cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag agatgggtgc     6540

gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat tcggttaagg     6600

ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag ggagctagaa     6660

cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca aatactggga     6720

cagctacaac catcccttca gacaggatca gaagaactta gatcattata taatacagta     6780

gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga agctttagac     6840

aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc cgctgatctt     6900

cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata aatataaagt     6960

agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag tggtgcagag     7020

agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag cagcaggaag     7080

cactatgggc gcagcctcaa tgacgctgac ggtacaggcc agacaattat tgtctggtat     7140

agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc tgttgcaact     7200

cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa gatacctaaa     7260

ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca ccactgctgt     7320

gccttggaat gctagttgga gtaataaatc tctggaacag attggaatca cacgacctgg     7380

atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa     7440

tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt     7500

ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata     7560

gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt     7620

aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccgac     7680

aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc cattcgatta     7740

gtgaacggat ctcgacggta tcgattagac tgtagcccag gaatatggca gctagattgt     7800

acacatttag aaggaaaagt tatcttggta gcagttcatg tagccagtgg atatatagaa     7860

gcagaagtaa ttccagcaga gacagggcaa gaaacagcat acttcctctt aaaattagca     7920

ggaagatggc cagtaaaaac agtacataca gacaatggca gcaatttcac cagtactaca     7980

gttaaggccg cctgttggtg ggcggggatc aagcaggaat ttggcattcc ctacaatccc     8040

caaagtcaag gagtaataga atctatgaat aaagaattaa agaaaattat aggacaggta     8100

agagatcagg ctgaacatct taagacagca gtacaaatgg cagtattcat ccacaatttt     8160

aaaagaaaag gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca     8220

acagacatac aaactaaaga attacaaaaa caaattacaa aaattcaaaa ttttcgggtt     8280

tattacaggg acagcagaga tccagtttgg ctgcatacgc gtcgtgaggc tccggtgccc     8340

gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga ggggtcggca     8400

attgaaccgg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat gtcgtgtact     8460

ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta gtcgccgtga     8520

acgttctttt tcgcaacggg tttgccgcca gaacacaggt aagtgccgtg tgtggttccc     8580

gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc ttgaattact tccacctggc     8640

tgcagtacgt gattcttgat cccgagcttc gggttggaag tgggtgggag agttcgaggc     8700

cttgcgctta aggagcccct tcgcctcgtg cttgagttga ggcctggcct gggcgctggg     8760

gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct cgctgctttc gataagtctc     8820

tagccattta aaatttttga tgacctgctg cgacgctttt tttctggcaa gatagtcttg     8880

taaatgcggg ccaagatctg cacactggta tttcggtttt tggggccgcg ggcggcgacg     8940

gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg cctgcgagcg cggccaccga     9000

gaatcggacg ggggtagtct caagctggcc ggcctgctct ggtgcctggc ctcgcgccgc     9060

cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc ggcaccagtt gcgtgagcgg     9120

aaagatggcc gcttcccggc cctgctgcag ggagctcaaa atggaggacg cggcgctcgg     9180

gagagcgggc gggtgagtca cccacacaaa ggaaaagggc ctttccgtcc tcagccgtcg     9240

cttcatgtga ctccacggag taccgggcgc cgtccaggca cctcgattag ttctcgagct     9300

tttggagtac gtcgtcttta ggttgggggg aggggtttta tgcgatggag tttccccaca     9360

ctgagtgggt ggagactgaa gttaggccag cttggcactt gatgtaattc tccttggaat     9420

ttgccctttt tgagtttgga tcttggttca ttctcaagcc tcagacagtg gttcaaagtt     9480

tttttcttcc atttcaggtg tcgtgagcta gctctagag                            9519


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  8

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  9
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  9
atctacatct gggcaccctt ggctggaaca tgcggggtcc tgctgctgag cttggtgatc       60

acccttta                                                                68


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  10

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
1               5                   10              


<210>  11
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  11
agcggaggtg gaggtagtgg cggtggaggc agctctggt                              39


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  12

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  13
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  13
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  14
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKG2D_CD27_CD3Zeta  CAR

<400>  14
ttcaaccaag aagttcaaat tcccttgacc gaaagttact gtggcccatg tcctaaaaac       60

tggatatgtt acaaaaataa ctgctaccaa ttttttgatg agagtaaaaa ctggtatgag      120

agccaggctt cttgtatgtc tcaaaatgcc agccttctga aagtatacag caaagaggac      180

caggatttac ttaaactggt gaagtcatat cattggatgg gactagtaca cattccaaca      240

aatggatctt ggcagtggga agatggctcc attctctcac ccaacctact aacaataatt      300

gaaatgcaga agggagactg tgcactctat gcctcgagct ttaaaggcta tatagaaaac      360

tgttcaactc caaatacgta catctgcatg caaaggactg tggctagcac cacgacgcca      420

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      480

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      540

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt      600

atcacccttt actgccaacg aaggaaatat agatcaaaca aaggagaaag tcctgtggag      660

cctgcagagc cttgtcgtta cagctgcccc agggaggagg agggcagcac catccccatc      720

caggaggatt accgaaaacc ggagcctgcc tgctccccca gagtgaagtt cagcaggagc      780

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga      840

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga      900

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg      960

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1020

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1080

gccctgcccc ctcgc                                                      1095


<210>  15
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D_CD27_CD3Zeta  CAR

<400>  15

Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
1               5                   10                  15      


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
            20                  25                  30          


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
        35                  40                  45              


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
    50                  55                  60                  


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
65                  70                  75                  80  


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
                85                  90                  95      


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
            100                 105                 110         


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
        115                 120                 125             


Cys Met Gln Arg Thr Val Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
    130                 135                 140                 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
145                 150                 155                 160 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
                165                 170                 175     


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            180                 185                 190         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Gln Arg Arg 
        195                 200                 205             


Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro 
    210                 215                 220                 


Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile 
225                 230                 235                 240 


Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys 
                245                 250                 255     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            260                 265                 270         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        275                 280                 285             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    290                 295                 300                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
305                 310                 315                 320 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                325                 330                 335     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            340                 345                 350         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365 


<210>  16
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKG2D_41BB_CD3Zeta CAR

<400>  16
ttcaaccaag aagttcaaat tcccttgacc gaaagttact gtggcccatg tcctaaaaac       60

tggatatgtt acaaaaataa ctgctaccaa ttttttgatg agagtaaaaa ctggtatgag      120

agccaggctt cttgtatgtc tcaaaatgcc agccttctga aagtatacag caaagaggac      180

caggatttac ttaaactggt gaagtcatat cattggatgg gactagtaca cattccaaca      240

aatggatctt ggcagtggga agatggctcc attctctcac ccaacctact aacaataatt      300

gaaatgcaga agggagactg tgcactctat gcctcgagct ttaaaggcta tatagaaaac      360

tgttcaactc caaatacgta catctgcatg caaaggactg tggctagcac cacgacgcca      420

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      480

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      540

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt      600

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt      660

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa      720

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      780

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat      840

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac      900

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag      960

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1020

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        1077


<210>  17
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D_41BB_CD3Zeta CAR

<400>  17

Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
1               5                   10                  15      


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
            20                  25                  30          


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
        35                  40                  45              


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
    50                  55                  60                  


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
65                  70                  75                  80  


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
                85                  90                  95      


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
            100                 105                 110         


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
        115                 120                 125             


Cys Met Gln Arg Thr Val Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
    130                 135                 140                 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
145                 150                 155                 160 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
                165                 170                 175     


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            180                 185                 190         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        195                 200                 205             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    210                 215                 220                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
225                 230                 235                 240 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                245                 250                 255     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            260                 265                 270         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        275                 280                 285             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    290                 295                 300                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
305                 310                 315                 320 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                325                 330                 335     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            340                 345                 350         


Met Gln Ala Leu Pro Pro Arg 
        355                 


<210>  18
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKG2D_CD3Zeta CAR

<400>  18
ttcaaccaag aagttcaaat tcccttgacc gaaagttact gtggcccatg tcctaaaaac       60

tggatatgtt acaaaaataa ctgctaccaa ttttttgatg agagtaaaaa ctggtatgag      120

agccaggctt cttgtatgtc tcaaaatgcc agccttctga aagtatacag caaagaggac      180

caggatttac ttaaactggt gaagtcatat cattggatgg gactagtaca cattccaaca      240

aatggatctt ggcagtggga agatggctcc attctctcac ccaacctact aacaataatt      300

gaaatgcaga agggagactg tgcactctat gcctcgagct ttaaaggcta tatagaaaac      360

tgttcaactc caaatacgta catctgcatg caaaggactg tggctagcac cacgacgcca      420

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      480

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      540

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt      600

atcacccttt actgcagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag      660

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg      720

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag      780

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg      840

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca      900

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c               951


<210>  19
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D_CD3Zeta CAR

<400>  19

Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
1               5                   10                  15      


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
            20                  25                  30          


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
        35                  40                  45              


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
    50                  55                  60                  


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
65                  70                  75                  80  


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
                85                  90                  95      


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
            100                 105                 110         


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
        115                 120                 125             


Cys Met Gln Arg Thr Val Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
    130                 135                 140                 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
145                 150                 155                 160 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
                165                 170                 175     


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            180                 185                 190         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Val Lys 
        195                 200                 205             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    210                 215                 220                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
225                 230                 235                 240 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                245                 250                 255     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            260                 265                 270         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        275                 280                 285             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315         


<210>  20
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3

<400>  20
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


