                         SEQUENCE LISTING

<110>  CARGILL INCORPORATED
       CARGILL INCORPORATED
 
<120>  METHODS AND CELLS FOR PRODUCING FATTY ACIDS AND FATTY ACID CHAIN 
       PRODUCTS

<130>  N00589-WO-PCT

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  325
<212>  PRT
<213>  Nocardia brasiliensis ATCC 700358

<400>  1

Met Asn Asn Ile Ala Val Leu Gly Thr Gly Ser Tyr Leu Pro Asp Arg 
1               5                   10                  15      


Ile Val Ser Asn Ser Glu Val Gly Ser Gly Ala Asp Val Asp Ser Glu 
            20                  25                  30          


Trp Ile Ile Arg Lys Thr Ala Ile Arg Glu Arg Arg Trp Ala Leu Pro 
        35                  40                  45              


Asp Gln Ala Thr Ser Asp Leu Ala Thr His Ala Ala Ser Ala Ala Leu 
    50                  55                  60                  


Asp Ala Ala Gly Ile Ser Ala Asp Glu Val Ser Ala Ile Val Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp His Pro Gln Pro Pro Thr Ala Ala Phe Val Gln 
                85                  90                  95      


His Asn Leu Gly Ala Arg Gly Ala Ser Ala Phe Asp Val Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Phe Val Phe Ala Leu Ser Ala Val Glu Ala Ala Ile Ala 
        115                 120                 125             


Arg Ala Gly Gly Gly Tyr Gly Leu Val Val Gly Ala Asp Val Tyr Ser 
    130                 135                 140                 


Arg Ile Leu Asn Pro Ala Asp Arg Arg Thr Val Val Leu Phe Gly Asp 
145                 150                 155                 160 


Gly Ala Gly Ala Val Val Leu Gly Pro Ser Ala Ser Gly Gly Leu Arg 
                165                 170                 175     


Arg Phe Gly Leu His Thr Phe Gly Asp Leu Thr Ser Leu Ile Arg Val 
            180                 185                 190         


Pro Ala Gly Gly Ser Arg Gln Pro Tyr Asp Pro Ala Ala His Glu Leu 
        195                 200                 205             


Gly Ala Gln Tyr Phe Thr Met Asp Gly Arg Gly Val Arg Ala Phe Val 
    210                 215                 220                 


Asn Gly Ser Leu Pro Val Leu Val Lys Gln Phe Leu His Asp Ser Gly 
225                 230                 235                 240 


Val Ala Pro Asp Asp Ile Thr His Leu Ile Pro His Gln Ala Asn Gly 
                245                 250                 255     


Val Met Leu Ala Glu Leu Ala Glu Glu Leu Gly Leu Val Asn Ala Thr 
            260                 265                 270         


Met His Thr Thr Val Arg Tyr Tyr Gly Asn Thr Gly Ala Ala Ser Ile 
        275                 280                 285             


Pro Ile Thr Leu Asp Asn Ala Ala Arg Thr Gly Gly Ile Arg Pro Gly 
    290                 295                 300                 


Asp Thr Val Leu Leu Val Gly Phe Gly Gly Gly Met Ala Val Gly Leu 
305                 310                 315                 320 


Thr Leu Val Glu Trp 
                325 


<210>  2
<211>  326
<212>  PRT
<213>  Streptomyces sp. KO-3988

<400>  2

Met Thr Asp Leu Arg Ile Leu Gly Thr Gly Ala Tyr Val Pro Glu Arg 
1               5                   10                  15      


Ile Ala Ser Asn Asp Glu Val Ala Ala Ala Ala Gly Val Asp Asp Ala 
            20                  25                  30          


Trp Ile Thr Ala Lys Thr Gly Ile Arg Glu Arg Arg Trp Ala Ala Asp 
        35                  40                  45              


Asp Gln Ala Thr Ser Asp Leu Ala Thr Ala Ala Gly Arg Ala Ala Leu 
    50                  55                  60                  


Arg Ser Ala Gly Ile Thr Ala Glu Asp Leu Ser Val Ile Val Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr Val Gln 
                85                  90                  95      


Gln Arg Leu Gly Ala Ser Asp Ala Ala Ala Phe Asp Val Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Met Val Phe Ala Leu Ala Ala Ala Glu Gly Val Leu Thr 
        115                 120                 125             


Arg Thr Gly Gly His Ala Leu Val Ile Gly Ala Asp Leu Tyr Ser Arg 
    130                 135                 140                 


Ile Leu Asn Arg Ala Asp Arg Arg Thr Val Ile Leu Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Val Ile Leu Gly Ser Ser Val Asp His Gly Pro Arg Ile 
                165                 170                 175     


Arg His Leu Ala Leu His Ser Phe Gly Glu Leu Ser Gly Leu Ile Glu 
            180                 185                 190         


Val Pro Ala Gly Gly Ser Arg Met Pro Val Asp Gln Thr Val Leu Asp 
        195                 200                 205             


Ala Gly Leu Gln Tyr Phe Ala Met Asp Gly Arg Gly Val Arg Asn Phe 
    210                 215                 220                 


Val Cys Asp His Leu Pro Gln Leu Val Lys Gly Phe Leu His Lys Cys 
225                 230                 235                 240 


Gly Val Val Pro Asp Asp Ile Asp His Phe Val Pro His Gln Ala Asn 
                245                 250                 255     


Gly Thr Met Leu Asp Ser Leu Phe Ala Asp Leu Glu Leu Pro Arg Ala 
            260                 265                 270         


Thr Met His Arg Thr Leu Thr His Tyr Ala Asn Thr Gly Ala Ala Ser 
        275                 280                 285             


Ile Pro Ile Thr Leu Asp Ala Ala Ala Arg Ala Gly Ala Phe Asn Pro 
    290                 295                 300                 


Gly Asp Leu Ile Leu Met Ala Gly Phe Gly Gly Gly Met Ser Ala Gly 
305                 310                 315                 320 


Phe Ala Leu Val Glu Trp 
                325     


<210>  3
<211>  333
<212>  PRT
<213>  Streptomyces cinnamonensis

<400>  3

Met Thr Gly Ile Ala Ala Asp Ile Ala Val Leu Gly Thr Gly Ala Tyr 
1               5                   10                  15      


Val Pro Asp Arg Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly 
            20                  25                  30          


Val Asp Gly Glu Trp Ile Val Arg Lys Thr Ala Ile Arg Glu Arg Arg 
        35                  40                  45              


Trp Ala Ala Pro Gly Gln Ala Thr Ser Asp Leu Ala Val Ala Ala Gly 
    50                  55                  60                  


Arg Ala Ala Leu Glu Ser Ala Gly Ile Thr Val Gly Gln Leu Ser Leu 
65                  70                  75                  80  


Ile Val Val Ala Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala 
                85                  90                  95      


Val Tyr Val Gln Gln Gln Leu Gly Ala Leu Gly Ala Ala Ala Phe Asp 
            100                 105                 110         


Val Asn Ala Val Cys Ser Gly Ser Val Phe Ala Leu Ser Val Val Glu 
        115                 120                 125             


Gly Met Leu Ala Arg Gln Gly Gly His Ala Leu Val Ile Gly Ala Asp 
    130                 135                 140                 


Val Tyr Ser Arg Ile Leu Asn Pro Ala Asp Arg Lys Thr Val Val Leu 
145                 150                 155                 160 


Phe Gly Asp Gly Ala Gly Ala Met Val Leu Gly Pro Ala Gly Gly Gly 
                165                 170                 175     


Arg Ala Ala Gly Ala Arg Val Arg His Val Thr Leu His Thr Val Gly 
            180                 185                 190         


Glu Leu Ala Gly Leu Ile Gln Val Pro Ala Gly Gly Ser Arg Gln Pro 
        195                 200                 205             


Ala Asp Gln Ala Val Leu Asp Ala Gly Leu Gln Tyr Phe Ala Met Asp 
    210                 215                 220                 


Gly Arg Glu Val Arg Arg Phe Val Val Glu Gln Leu Pro Gln Leu Thr 
225                 230                 235                 240 


Lys Gln Phe Leu His Glu Ala Gly Val Val Pro Asp Asp Val Ala His 
                245                 250                 255     


Phe Val Pro His Gln Ala Asn Gly Val Met Leu Asp Thr Val Ile Glu 
            260                 265                 270         


Asp Leu Ala Leu Ser Arg Ala Thr Thr His Leu Thr Leu Glu Arg Tyr 
        275                 280                 285             


Gly Asn Thr Gly Ala Ala Ser Ile Pro Ile Thr Leu Asp Ala Ala Ala 
    290                 295                 300                 


Arg Glu Gly Ala Phe Arg Pro Gly Asp Leu Ile Leu Leu Ala Gly Phe 
305                 310                 315                 320 


Gly Gly Gly Met Ala Ala Gly Leu Ala Leu Leu Glu Trp 
                325                 330             


<210>  4
<211>  325
<212>  PRT
<213>  Streptomyces tendae

<400>  4

Met Ser Asp Val Arg Ile Leu Gly Thr Gly Ala Tyr Val Pro Asp Arg 
1               5                   10                  15      


Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp Asp Ala 
            20                  25                  30          


Trp Ile Thr Ala Lys Thr Ala Ile Arg Glu Arg Arg Trp Ala Ala Thr 
        35                  40                  45              


His Gln Ala Thr Ser Asp Leu Ala Thr Gln Ala Ala Arg Asn Ala Leu 
    50                  55                  60                  


Asp Cys Ala Gly Ile Thr Ala Ala Glu Leu Thr Val Ile Ile Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr Val Gln 
                85                  90                  95      


His Asn Leu Ala Ala Thr His Ala Ala Ala Phe Asp Ile Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Glu Ile Phe Ala Leu Ser Ala Ala Glu Gly Thr Leu Ala 
        115                 120                 125             


Arg Lys Gly Gly His Ala Leu Ile Ile Gly Ala Asp Leu Tyr Ser Arg 
    130                 135                 140                 


Ile Leu Asn Pro Thr Asp Arg Lys Thr Thr Val Leu Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Met Ile Leu Gly Pro Ala Thr Thr Gly Pro Arg Ile Arg 
                165                 170                 175     


His Leu Thr Leu His Thr Tyr Gly Glu His Ser Asp Leu Ile Gln Val 
            180                 185                 190         


Pro Ala Gly Gly Ser Arg Leu Pro Thr Thr Thr Gln Thr Leu Gln Gln 
        195                 200                 205             


Asp Gln His Tyr Phe Thr Met Asp Gly Arg Gly Val Arg Arg Phe Val 
    210                 215                 220                 


Ala Asp His Leu Pro Arg Leu Thr Lys Glu Phe Leu His Glu Ala Gly 
225                 230                 235                 240 


Thr Val Pro Asp Asp Ile Arg His Phe Ile Pro His Gln Ala Asn Gly 
                245                 250                 255     


Val Met Leu Asp Asp Leu Phe Thr Gln Leu Ala Leu Pro His Ala Thr 
            260                 265                 270         


Met His Gln Thr Leu Thr Thr Tyr Ala Asn Thr Gly Ala Ala Ser Ile 
        275                 280                 285             


Pro Leu Thr Leu Asp Thr Ala His Arg Asn Asn Ala Leu His Pro Gly 
    290                 295                 300                 


Asp Leu Ile Leu Leu Ala Gly Phe Gly Gly Gly Met Ala Ala Gly Leu 
305                 310                 315                 320 


Ala Leu Ile Glu Trp 
                325 


<210>  5
<211>  324
<212>  PRT
<213>  Streptomyces sp. KO-3988

<400>  5

Met Thr Glu Val Gly Ile Leu Gly Thr Gly Ala Gln Val Pro Asp Arg 
1               5                   10                  15      


Val Val Ser Asn Asp Glu Ala Gly Ala Ala Ala Gly Val Asp Asp Ala 
            20                  25                  30          


Trp Val Val Arg Lys Thr Ala Ile Arg Glu Arg Arg Trp Ala Ala Pro 
        35                  40                  45              


Glu Gln Ala Thr Ser Asp Leu Ala Ala Ala Ala Gly Ser Ala Ala Leu 
    50                  55                  60                  


Arg Ser Ala Gly Ile Thr Pro Asp Gln Leu Ser Val Ile Val Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr Val Gln 
                85                  90                  95      


Gln Leu Leu Gly Ala Val Gly Ala Ala Ala Phe Asp Val Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Glu Val Phe Ala Leu Ala Ala Ala Glu Gly Ile Leu Thr 
        115                 120                 125             


Arg Arg Gly Gly His Ala Leu Val Ile Gly Ala Asp Val Tyr Ser Arg 
    130                 135                 140                 


Ile Leu Asn Pro Ala Asp Arg Arg Thr Val Val Leu Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Met Val Leu Gly Pro Gly Arg Gly Ala Arg Val Arg Asn 
                165                 170                 175     


Leu Ala Leu His Thr Phe Gly Glu Leu Ala Gly Leu Ile Glu Val Pro 
            180                 185                 190         


Ala Gly Gly Ser Arg Arg Pro Ala Asp Gln Ala Ala Leu Asp Ala Gly 
        195                 200                 205             


Leu Gln Tyr Phe Thr Met Asp Gly Arg Ala Val Arg Ser Phe Val Glu 
    210                 215                 220                 


Asp Arg Leu Pro Leu Leu Thr Lys Gln Phe Leu His Asp Ser Gly Val 
225                 230                 235                 240 


Gly Pro Asp Asp Ile Arg His Phe Val Pro His Gln Ala Asn Gly Val 
                245                 250                 255     


Met Leu Asp Ala Leu Phe Ala Glu Leu Ala Leu Asn Arg Ala Val Met 
            260                 265                 270         


His Arg Thr Leu Thr His Tyr Gly Asn Thr Gly Ala Ala Ser Ile Pro 
        275                 280                 285             


Ile Thr Leu Ala Glu Ala Ala Arg Ser Gly Ala Phe Arg Pro Gly Asp 
    290                 295                 300                 


Leu Ile Leu Leu Ala Gly Phe Gly Gly Gly Met Ala Val Gly Phe Ala 
305                 310                 315                 320 


Leu Val Glu Trp 
                


<210>  6
<211>  325
<212>  PRT
<213>  Austwickia chelonae NBRC 105200

<400>  6

Met Gly Val Ala Val Trp Gly Thr Gly Ala Tyr Val Pro Glu Arg Ile 
1               5                   10                  15      


Val Thr Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp Asp Ala Trp 
            20                  25                  30          


Ile Arg Ser Lys Thr Met Ile Arg Glu Arg Arg Trp Val Ala Glu Asn 
        35                  40                  45              


Glu Ala Thr Ser Asp Met Ala Thr Glu Ala Gly Arg Arg Ala Leu Glu 
    50                  55                  60                  


Ala Ala Gly Ile Thr Ala Asp Glu Leu Ser Tyr Ile Val Val Ala Thr 
65                  70                  75                  80  


Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr Val Gln His 
                85                  90                  95      


Asn Leu Gln Ala His His Ala Ala Gly Phe Asp Met Asn Ala Val Cys 
            100                 105                 110         


Ser Gly Phe Val Phe Ala Gly Ser Thr Val Ala Arg Met Ile Ala Ala 
        115                 120                 125             


Thr Gly Gly Tyr Gly Leu Val Ile Gly Ala Asp Val Tyr Ser Arg Ile 
    130                 135                 140                 


Leu Asn Pro Arg Asp Arg Arg Thr Val Ile Leu Phe Gly Asp Gly Ala 
145                 150                 155                 160 


Gly Ala Val Val Leu Gly Pro Ser Asp Gly Ser Asn His Gly Val Leu 
                165                 170                 175     


Ala Thr Ser Leu His Thr Phe Gly Ala Leu Asn Asp Lys Ile Met Val 
            180                 185                 190         


Pro Ala Gly Gly Ser Arg Leu Pro Thr Glu Asp Thr His Tyr Glu Thr 
        195                 200                 205             


Gly Leu Ala Tyr Phe Thr Met Glu Gly Arg Ala Val Lys Glu Phe Val 
    210                 215                 220                 


Leu Gln Glu Leu Pro Pro Leu Val Asp Ser Phe Phe Ala Glu Thr Gly 
225                 230                 235                 240 


Ile Ser Pro Gln Glu Val Asp His Phe Ile Pro His Gln Ala Asn Gly 
                245                 250                 255     


Met Met Leu Asp Glu Leu Val Pro Thr Leu Gly Leu Ser Gly Ala Arg 
            260                 265                 270         


Thr His Arg Thr Leu Glu Lys Tyr Gly Asn Thr Gly Ala Ala Ser Val 
        275                 280                 285             


Gly Ile Thr Leu Asp Gln Ala Ala Arg Glu Gly Glu Leu His Ser Gly 
    290                 295                 300                 


Asp Arg Ile Phe Leu Ala Gly Phe Gly Gly Gly Met Ala Ala Gly Leu 
305                 310                 315                 320 


Ala Leu Ile Val Trp 
                325 


<210>  7
<211>  330
<212>  PRT
<213>  Streptomyces sp. Mg1

<400>  7

Met Ser Ala Arg Gly Ile Val Gly Thr Gly Ser Tyr Leu Pro Glu Arg 
1               5                   10                  15      


Glu Val Ser Asn Lys Glu Val Ala Glu Trp Cys Gly Ile Thr Ala Glu 
            20                  25                  30          


Trp Ile Glu Glu Arg Thr Glu Ile Leu Thr Arg Arg Tyr Ala Ala Pro 
        35                  40                  45              


Asp Glu Ala Thr Ser Asp Leu Ala Ala His Ala Leu Thr Ser Ala Leu 
    50                  55                  60                  


Arg Ser Ala Gly Ile Thr Ala Asp Arg Leu Asp Tyr Leu Ile Val Ser 
65                  70                  75                  80  


Thr Ser Thr Gly Asp Ser Pro Gln Pro Pro Thr Ala Asn Leu Val Gln 
                85                  90                  95      


His Ala Val Gly Ala Thr Gly Ala Ala Cys Phe Asp Val Asn Val Val 
            100                 105                 110         


Cys Ser Gly Phe Val Phe Gly Leu Glu Met Ala His Arg Leu Leu Ala 
        115                 120                 125             


Ala Arg Pro Asp Gly Tyr Ala Ala Val Ile Gly Ala Asp Val Tyr Ser 
    130                 135                 140                 


Arg Ile Leu Asp His Ala Asp His Arg Thr Thr Val Leu Leu Gly Asp 
145                 150                 155                 160 


Gly Ala Gly Ala Ala Ile Val Gly Pro Val Arg Asp Gly His Gly Tyr 
                165                 170                 175     


Leu Gly Ala Glu Leu Ala Ser Arg Gly Asp Ala His Arg Leu Ile Arg 
            180                 185                 190         


Val Glu Ala Gly Gly Ser Arg Ile Pro Thr Thr Pro Gln Thr Leu Ala 
        195                 200                 205             


Asp Gly Gly His Tyr Phe Arg Met Glu Gly Arg Gly Val Arg Asp Phe 
    210                 215                 220                 


Val Met Asp His Val Pro Pro Val Leu Asp Arg Leu Leu Arg Gly Ala 
225                 230                 235                 240 


Gly Leu Thr Ala Ala Asp Val Asp His Phe Val Pro His Gln Pro Asn 
                245                 250                 255     


Gly Val Leu Leu Arg Gly Leu Val Asp Lys Ile Gly Met Ser His Ala 
            260                 265                 270         


His Thr His Arg Thr Leu Glu Lys Tyr Gly Asn Val Gly Ser Ala Ser 
        275                 280                 285             


Val Pro Val Ala Leu Asp Asp Gly Cys Arg Ser Gly Leu Ile Arg Asp 
    290                 295                 300                 


Gly Asp Leu Val Val Met Ala Gly Phe Gly Gly Gly Met Ser Val Gly 
305                 310                 315                 320 


Ala Thr Leu Met Arg Trp Gln Glu Arg Ser 
                325                 330 


<210>  8
<211>  346
<212>  PRT
<213>  Spirochaeta africana DSM 8902

<400>  8

Met His Ser Lys His Thr Glu Leu Gln Glu Ala Val Ile Thr Gly Ala 
1               5                   10                  15      


Gly Ala Tyr Val Pro Pro Arg Arg Met Ser Asn Asp Glu Leu Ala Gly 
            20                  25                  30          


Phe Leu Asp Thr Ser Asp Glu Trp Ile Phe Ser Lys Thr Gly Ile His 
        35                  40                  45              


Asn Arg His Ile Ala Ala Glu Asp Gln Ala Thr Ser Asp Leu Gly Ala 
    50                  55                  60                  


Ala Ala Ala Arg Gln Ala Leu Ala Asp Ala Gly Leu Thr Pro Leu Asp 
65                  70                  75                  80  


Ile Asp Leu Ile Leu Val Ala Thr Ser Ser Pro Asp Tyr Asn Gly Leu 
                85                  90                  95      


Pro Ser Thr Ala Cys Val Val Gln Asp Leu Leu Gly Ala Thr Asn Ala 
            100                 105                 110         


Ala Ala Met Asp Val Ala Ala Val Cys Ser Gly Phe Val Tyr Ala Leu 
        115                 120                 125             


Glu Thr Ala Arg Ala Phe Ala Arg Ser Gly Ser Ala Arg Arg Ile Leu 
    130                 135                 140                 


Val Ile Gly Ala Glu Ile Tyr Ser Arg Val Val Asp Trp Ser Asp Arg 
145                 150                 155                 160 


Ser Thr Cys Val Leu Phe Gly Asp Gly Ala Gly Ala Val Val Val Glu 
                165                 170                 175     


Ser Leu Pro Glu Ser Ala Gly Asn Thr Ala Pro Arg Phe Pro Arg Ala 
            180                 185                 190         


Arg Val Leu Asp Ser Val Leu Lys Ser Arg Gly Ser Asp Ala Gln Ala 
        195                 200                 205             


Leu Val Arg Pro Ala Gly Gly Thr Arg Arg Pro Val Asn Pro Gly Asp 
    210                 215                 220                 


Asn Phe Gly Ala Asp Gln Phe Leu Gln Met Asp Gly Arg Lys Val Tyr 
225                 230                 235                 240 


Asn Phe Ala Val Gly Ala Ile Gly Glu Val Ile Gln Glu Leu Leu Thr 
                245                 250                 255     


Arg Asn Gly Leu Ser Leu Ala Glu Leu Asp Trp Val Ile Pro His Gln 
            260                 265                 270         


Ala Asn Ala Arg Ile Leu Glu Ala Ala Ala Arg Arg Leu Lys Tyr Pro 
        275                 280                 285             


Val Glu Gln Met Tyr Ser Asn Ile Ala Glu Tyr Ala Asn Thr Ser Ala 
    290                 295                 300                 


Ala Ser Ile Pro Ile Ala Met Asn Glu Met Ala Ala Ala Gly Met Leu 
305                 310                 315                 320 


Lys Pro Gly Gln Asn Ile Ile Thr Val Gly Phe Gly Ala Gly Leu Thr 
                325                 330                 335     


Tyr Gly Gly Asn Leu Leu Arg Thr Val Val 
            340                 345     


<210>  9
<211>  333
<212>  PRT
<213>  Streptomyces sp. HKI0576

<400>  9

Met Thr Ser Ala Ile Gly Ile Leu Gly Thr Gly Ala Tyr Leu Pro Ala 
1               5                   10                  15      


Arg Glu Val Gly Asn Asp Glu Leu Ala Ala Leu Ile Pro Asp Thr Thr 
            20                  25                  30          


Ala Glu Trp Ile Leu Arg Lys Thr Gly Ile Arg Ser Arg Arg Tyr Ala 
        35                  40                  45              


Ala Pro Asp Glu Ala Ala Ser Asp Leu Ala Ala Gly Ala Ala Arg Ala 
    50                  55                  60                  


Ala Leu Ala Asp Ala Gly Leu Thr Ala Asp Arg Val Asp His Ile Ile 
65                  70                  75                  80  


Val Cys Thr Ser Thr Gly Asp Gln Pro Leu Pro Pro Thr Ala Ser Val 
                85                  90                  95      


Val Gln Gln Leu Leu Gly Ala Gly Ser Ala Ala Cys Phe Asp Leu Asn 
            100                 105                 110         


Ala Val Cys Ala Gly Phe Val Tyr Gly Leu Glu Ala Ala Arg Gly Leu 
        115                 120                 125             


Ile Ala Val Arg Pro Gly Ala His Val Leu Leu Ile Gly Ala Asp Val 
    130                 135                 140                 


Tyr Ser Arg Phe Leu Asp Phe Thr Asp Arg Arg Ser Ala Val Leu Leu 
145                 150                 155                 160 


Gly Asp Gly Ala Gly Ala Val Val Val Gly Ala Val Glu Asp Gly Asn 
                165                 170                 175     


Gly Ile Leu Gly Ile Asp Leu Ser Thr Arg Gly Asp Ala Gln Asp Leu 
            180                 185                 190         


Leu Arg Ile Pro Ala Gly Gly Ser Arg Ser Pro Ala Ser Ala Gly Thr 
        195                 200                 205             


Val Ala Glu Gly Gly His His Leu Arg Met Gln Gly Arg Ala Val Ser 
    210                 215                 220                 


Glu Phe Val Leu Glu Asn Ile Pro Pro Gly Val Asp Lys Leu Leu Ala 
225                 230                 235                 240 


Gly Ala Gly Val Arg Ala Glu Glu Ile Asp Cys Phe Val Pro His Gln 
                245                 250                 255     


Ala Asn Ala Val Leu Ile Arg Glu Leu Ala Ala Arg Cys Gly Leu Ala 
            260                 265                 270         


Asp Thr Pro Leu Val Gln Val Val Glu Thr Tyr Gly Asn Thr Gly Ala 
        275                 280                 285             


Ala Ser Val Pro Ile Gly Leu Asp His Ala Val Arg Glu Gly Thr Val 
    290                 295                 300                 


Glu Pro Gly Gly Leu Val Leu Leu Ser Ala Phe Gly Ala Gly Met Ser 
305                 310                 315                 320 


Val Gly Asn Gly Leu Leu Arg Trp Gly Gly Gly Pro Ala 
                325                 330             


<210>  10
<211>  345
<212>  PRT
<213>  Streptomyces violaceusniger Tu 4113

<400>  10

Met Thr Asp His Pro Val Arg Thr Pro Gly Gly Arg Pro Val Gly Ile 
1               5                   10                  15      


Leu Gly Thr Gly Ser Tyr Leu Pro Ala Glu Ala Val Ser Asn Glu Leu 
            20                  25                  30          


Val Ala Glu Arg Ala Gly Val Thr Ala Glu Trp Ile Ala Ala Lys Thr 
        35                  40                  45              


Gly Ile Arg Arg Arg Arg Tyr Ala Ala Asp His Glu Ala Thr Ser Asp 
    50                  55                  60                  


Leu Ala Val Glu Ala Ala Arg Ala Ala Leu Ala Asp Ala Gly Ile Arg 
65                  70                  75                  80  


Ala Gly Gln Leu Gly Trp Ile Val Val Ala Thr Ser Thr Pro Asp His 
                85                  90                  95      


Pro Gln Pro Ala Thr Ala Cys Leu Val Gln His Arg Ile Gly Ala Thr 
            100                 105                 110         


Gly Ala Ala Ala Phe Asp Ile Asn Ala Val Cys Ser Gly Phe Val Phe 
        115                 120                 125             


Ala Leu Val Thr Ala Ala Gly Leu Leu Ala Gly Ser Gly Ala Pro Ala 
    130                 135                 140                 


Pro Tyr Ala Leu Val Ile Gly Ala Asp Val Tyr Ser Arg Ile Ile Asp 
145                 150                 155                 160 


Arg Thr Asp Arg Arg Thr Ala Val Leu Phe Gly Asp Gly Ala Gly Ala 
                165                 170                 175     


Val Val Leu Gly Pro Val Arg His Gly Tyr Gly Leu Thr Gly Ser Leu 
            180                 185                 190         


Leu Thr Ser Asp Gly Ala Leu His Glu Leu Ile Gln Val Pro Ala Gly 
        195                 200                 205             


Gly Ser Arg Ala Pro Ala Ser Glu Lys Thr Leu Ala Asp Gly Gly His 
    210                 215                 220                 


Phe Phe Arg Met Arg Gly Arg Ala Val Gly Glu Tyr Val Leu Ala Glu 
225                 230                 235                 240 


Leu Pro Arg Ala Ile Arg Ala Leu Leu Ala Ala His Arg Thr Asp Ala 
                245                 250                 255     


Ala Gly Val Asp His Phe Ile Pro His Gln Ala Asn Gly Val Leu Leu 
            260                 265                 270         


Ala Lys Ala Leu Pro Asp Leu Gly Leu Pro Arg Ala Arg Thr His Leu 
        275                 280                 285             


Thr Val Ala Glu His Gly Asn Thr Ser Ala Ala Ser Ile Pro Leu Ala 
    290                 295                 300                 


Leu Asp Asp Ala Arg Arg Gln Gly Val Phe Thr Asp Gly Glu Leu Leu 
305                 310                 315                 320 


Leu Leu Ala Gly Phe Gly Gly Gly Met Ser Leu Gly Ala Ala Leu Val 
                325                 330                 335     


Arg Trp Gln Asp Gly His Gly Gly Ser 
            340                 345 


<210>  11
<211>  338
<212>  PRT
<213>  Amycolatopsis sp. ATCC 39116

<400>  11

Met Met Lys Thr Val Val Leu Gly Thr Gly Ser Tyr Leu Pro Pro Thr 
1               5                   10                  15      


Val Leu Thr Ser Thr Glu Leu Gly Asp Arg Leu Gly Thr Gly Gly Gln 
            20                  25                  30          


Trp Ile Val Asp Lys Thr His Ile Arg Glu Arg Arg Val Ala Asp Gly 
        35                  40                  45              


Ser Glu Ala Thr Ser Asp Leu Ala Thr Ala Ala Ala Arg Arg Ala Leu 
    50                  55                  60                  


Gln Ser Ser Gly Thr Ser Pro Asp Glu Leu Asp Leu Val Ile Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp Gln Pro Ile Pro Ala Thr Ala Ala Leu Val Gln 
                85                  90                  95      


Ala Asn Ile Ser Ala Asp Arg Ala Ala Ala Phe Asp Val Asp Ala Val 
            100                 105                 110         


Cys Ser Gly Phe Val Tyr Ala Leu Val Val Ala His Gly Met Leu Leu 
        115                 120                 125             


Ala Asp Asp Ser Cys Arg Lys Ala Leu Val Ile Gly Ala Asp Ile Tyr 
    130                 135                 140                 


Ser Arg Ile Leu Asp Tyr Asp Asp Arg Arg Thr Ala Val Leu Phe Gly 
145                 150                 155                 160 


Asp Gly Ala Gly Ala Val Val Leu Gly Lys Thr Asn Ala Asp Arg Gly 
                165                 170                 175     


Ile His Thr Thr Leu Leu Gly Cys Asp Gly Lys Arg Ala Asp Leu Val 
            180                 185                 190         


Gln Val Pro Ala Gly Gly Ser Arg Arg Pro Ala Ser Pro Gln Thr Leu 
        195                 200                 205             


Ala Asp Gly Leu His Tyr Phe Lys Met Ile Gly Arg Pro Val Arg Glu 
    210                 215                 220                 


Leu Ala Gly Gln Val Met Pro Glu Val Val Glu Gln Leu Leu Lys Arg 
225                 230                 235                 240 


Ala Gly Leu Thr Leu Asp Asp Val Gln His Leu Val Pro His Gln Ala 
                245                 250                 255     


Asn Gly Val Met Leu Ala Glu Leu Asp Ser Ala Leu Gly Leu Ala Pro 
            260                 265                 270         


Gly Val Met Cys Arg Thr Val Glu His Phe Gly Asn Thr Gly Ala Ala 
        275                 280                 285             


Ser Val Pro Ile Thr Leu Asp His Ala Val Arg Gly Gly Gln Ile Gly 
    290                 295                 300                 


Glu Asp Asp Arg Val Val Leu Val Thr Phe Gly Gly Gly Met Ser Trp 
305                 310                 315                 320 


Gly Gly Ala Leu Leu Thr Trp Ala Tyr Thr His Gly Glu Glu Thr Ser 
                325                 330                 335     


His Asp 
        


<210>  12
<211>  329
<212>  PRT
<213>  hypothetical protein ACD_77C00103G0010 [uncultured bacterium]

<400>  12

Met Lys Gln Leu Ile Arg Asn Val Lys Ile Ile Gly Thr Gly Ser Tyr 
1               5                   10                  15      


Val Pro Glu Lys Ile Tyr Thr Asn Glu Tyr Leu Glu Thr Phe Ile Ser 
            20                  25                  30          


Thr Thr Ser Ser Trp Ile Phe Glu Asn Ile Gly Ile Lys Glu Arg His 
        35                  40                  45              


Ile Ala Ala Pro Asn Gln Ala Thr Ser Asp Leu Ala Thr Ile Ala Gly 
    50                  55                  60                  


Gln Arg Ala Ile Asp Asp Ala Gly Ile Lys Asn Glu Asp Ile Asp Leu 
65                  70                  75                  80  


Ile Ile Val Ala Thr Ala Thr Pro Asp Arg Lys Ala Pro Ser Thr Ala 
                85                  90                  95      


Ala Phe Val Gln His Lys Leu Asn Ala Val Asn Ala Ala Ala Phe Asp 
            100                 105                 110         


Met Asn Ala Val Cys Ser Gly Phe Leu Phe Gly Met Ser Val Ala Ser 
        115                 120                 125             


Gln Tyr Ile Ala Ser Gly Val Tyr Asn Asn Ile Leu Val Ile Gly Ala 
    130                 135                 140                 


Asp Thr Phe Ser Arg Ile Thr Asp Trp Thr Lys Arg Asp Ala Val Phe 
145                 150                 155                 160 


Phe Gly Asp Gly Ala Gly Ala Val Val Ile Thr Ser Ala Asn Ile Thr 
                165                 170                 175     


Glu Gly Phe Leu Ala Tyr Arg Ile Tyr Thr Asp Thr Gln Asn Glu Met 
            180                 185                 190         


Leu Gly Phe Thr Ile Pro Gly Gly Gly Ser Glu Ile Pro Leu Thr Glu 
        195                 200                 205             


Asn Asn Leu Asn Asp Gln Tyr Phe Gln Met Asn Gly Lys Ser Val Phe 
    210                 215                 220                 


Ala Ser Ala Thr Gln Ala Leu Pro Lys Ala Ile Asn Gln Val Leu Ala 
225                 230                 235                 240 


Asp Thr Gly Leu Thr Ile Gly Asp Ile Asp Ile Met Ile Pro His Gln 
                245                 250                 255     


Pro Ser Ile Arg Ile Leu Gln Lys Thr Ala Glu Leu Ile Gly Leu Pro 
            260                 265                 270         


Phe Glu Lys Val Met Thr Asn Met Asp Arg Tyr Ala Asn Thr Ser Gly 
        275                 280                 285             


Gly Thr Ile Pro Ile Leu Leu Asp Glu Val Lys Lys Ser Gly Lys Leu 
    290                 295                 300                 


Lys Arg Gly Asn Ile Val Leu Phe Ala Ala Val Gly Ser Gly Trp Thr 
305                 310                 315                 320 


Tyr Gly Ala Ser Ile Ile Lys Trp Ala 
                325                 


<210>  13
<211>  326
<212>  PRT
<213>  Geobacter sulfurreducens PCA

<400>  13

Met Met Arg Ala Arg Ile Val Gly Thr Gly Ser Ala Val Pro Ser Lys 
1               5                   10                  15      


Val Leu Thr Asn Phe Asp Leu Glu Lys Met Val Asp Thr Ser Asp Glu 
            20                  25                  30          


Trp Val Thr Thr Arg Thr Gly Ile Lys Glu Arg Arg Ile Ala Val Asp 
        35                  40                  45              


Gly Glu Tyr Thr Ser Thr Phe Ala Thr Leu Ala Ala Glu Arg Ala Leu 
    50                  55                  60                  


Glu Met Ala Gly Val Lys Ala Ser Asp Leu Asp Leu Leu Ile Val Ala 
65                  70                  75                  80  


Thr Ile Thr Pro Asp Phe Pro Phe Pro Ala Thr Ala Cys Val Val Gln 
                85                  90                  95      


Ser Asn Leu Lys Ala Thr Lys Ala Ala Ala Tyr Asp Ile Ser Ala Ala 
            100                 105                 110         


Cys Ser Gly Phe Ile Tyr Ala Leu Ala Gln Ala Ser Asn Ala Ile Arg 
        115                 120                 125             


Ser Gly Ser Ala Arg Lys Ala Leu Val Ile Gly Ala Glu Val Leu Ser 
    130                 135                 140                 


Arg Ile Ile Asp Trp Thr Asp Arg Asn Thr Cys Leu Leu Phe Gly Asp 
145                 150                 155                 160 


Gly Ala Gly Ala Val Val Leu Glu Ala Cys Asp Asp Gly His Gly Val 
                165                 170                 175     


Leu Ser Thr His Leu His Ser Asp Gly Ser Tyr Trp Glu Leu Leu Tyr 
            180                 185                 190         


Gln Pro Gly Cys Gly Asn Arg Asn Pro Ala Val Gln Lys Thr Leu Asp 
        195                 200                 205             


Asp Arg Arg Ile Tyr Leu Met Met Gln Gly Asn Glu Val Phe Lys Leu 
    210                 215                 220                 


Ala Val Arg Ala Met Glu Asp Ala Ala Leu Glu Ala Leu Asp Ala Asn 
225                 230                 235                 240 


Gly Leu Thr Pro Ala Asp Ile Ser Leu Phe Ile Pro His Gln Ala Asn 
                245                 250                 255     


Arg Arg Ile Ile Asp Ala Ile Gly Lys Arg Leu Gly Leu Pro Gly Glu 
            260                 265                 270         


Lys Val Tyr Val Asn Leu Asp Arg Phe Gly Asn Thr Ser Ala Ala Ser 
        275                 280                 285             


Ile Pro Leu Ala Leu Asp Glu Ala Asn Arg Ser Gly Arg Ile Lys Pro 
    290                 295                 300                 


Asn Asp Val Val Val Phe Asp Ala Phe Gly Gly Gly Leu Thr Trp Gly 
305                 310                 315                 320 


Ser Ala Leu Val Arg Trp 
                325     


<210>  14
<211>  368
<212>  PRT
<213>  Acinetobacter baylyi DSM 14961 = CIP 107474

<400>  14

Met Gly Ile Arg Ile Thr Gly Thr Gly Leu Tyr His Pro Ala Glu Ser 
1               5                   10                  15      


Ile Ser Asn Glu Glu Leu Val Glu Ser Leu Asn Ala Tyr Val Glu Tyr 
            20                  25                  30          


Tyr Asn Ala Glu Asn Ala Glu Lys Ile Ala Ala Gly Glu Leu Pro Glu 
        35                  40                  45              


Arg Leu Gly Ser Ser Ala Glu Phe Ile Glu Lys Ala Ser Gly Ile Lys 
    50                  55                  60                  


Ser Arg Tyr Val Ile Glu Lys Ser Gly Val Leu Asp Pro Gln Arg Leu 
65                  70                  75                  80  


Arg Pro Arg Leu Gln Glu Arg Thr Asp Asp Glu Leu Ser Ile Gln Ala 
                85                  90                  95      


Glu Trp Gly Val Leu Ala Ala Lys Gln Ala Met Glu Asn Ala Lys Val 
            100                 105                 110         


Thr Ala Glu Asp Ile Asp Val Val Ile Leu Ala Cys Ser Asn Met Gln 
        115                 120                 125             


Arg Pro Tyr Pro Ala Val Ala Val Glu Ile Gln Ser Ala Leu Gly Ile 
    130                 135                 140                 


Gln Gly Tyr Ala Tyr Asp Met Asn Val Ala Cys Ser Ala Ala Thr Phe 
145                 150                 155                 160 


Gly Leu Lys Gln Ala Tyr Asp Ala Ile Gln Ser Gly Ala Arg Arg Val 
                165                 170                 175     


Leu Leu Val Asn Val Glu Ile Thr Ser Gly His Thr Asp Tyr Arg Ser 
            180                 185                 190         


Arg Asp Cys His Phe Ile Phe Gly Asp Val Ala Thr Ala Ser Ile Ile 
        195                 200                 205             


Glu Gln Thr Asp Thr Lys Thr Gly Phe Glu Ile Leu Asn Ile His Leu 
    210                 215                 220                 


Phe Thr Gln Phe Ser Asn Asn Ile Arg Asn Asn Phe Gly Phe Leu Asn 
225                 230                 235                 240 


Arg Ser Glu Asp Ala Thr Arg Asp Asp Lys Gln Phe Arg Gln Asp Gly 
                245                 250                 255     


Arg Lys Val Phe Lys Asp Val Cys Pro Leu Val Ala Lys Ile Ile Thr 
            260                 265                 270         


Ala Gln Leu Glu Lys Asn Gln Val Asn Pro Gln Asp Ile Lys Arg Phe 
        275                 280                 285             


Trp Leu His Gln Ala Asn Leu Asn Met Asn Gln Leu Ile Ala Lys Leu 
    290                 295                 300                 


Val Leu Gly Lys Glu Ala Glu Ala Glu Arg Thr Pro Ile Ile Leu Asp 
305                 310                 315                 320 


Glu Phe Ala Asn Thr Ser Ser Ala Gly Val Ile Ile Ala Leu His Arg 
                325                 330                 335     


Thr Gly Glu Glu Val Ser Glu Gly Glu Phe Gly Val Ile Cys Ser Phe 
            340                 345                 350         


Gly Ala Gly Tyr Ser Val Gly Ser Leu Leu Val Gln Lys Arg Val Ala 
        355                 360                 365             


<210>  15
<211>  334
<212>  PRT
<213>  Clostridium tetani E88

<400>  15

Met Lys Asn Lys Glu Val Arg Ile Leu Ser Thr Gly Lys Tyr Leu Pro 
1               5                   10                  15      


Pro Ile Ser Ile Ser Asn His Asp Leu Ser Lys Ile Ile Asp Thr Asn 
            20                  25                  30          


Asp Asn Trp Ile Lys Thr Arg Thr Gly Ile Glu Lys Arg Arg Ile Thr 
        35                  40                  45              


Lys Gly Glu Asn Thr Ser Asp Leu Gly Thr Lys Ala Ala Leu Asp Ala 
    50                  55                  60                  


Leu Arg Lys Gly Gly Ile Ser Pro Glu Glu Leu Asp Leu Ile Ile Val 
65                  70                  75                  80  


Ala Thr Ile Thr Pro Asp Tyr Phe Thr Pro Ser Thr Ala Cys Ile Ile 
                85                  90                  95      


Gln Arg Asn Ile Lys Ala Tyr Asn Ala Phe Ala Phe Asp Ile Ser Ala 
            100                 105                 110         


Ala Cys Ser Gly Phe Thr Tyr Gly Ile Ser Ile Ala Ser Gln Phe Ile 
        115                 120                 125             


Arg Asn Gly Val Ala Lys Lys Val Leu Val Ile Gly Val Glu Thr Leu 
    130                 135                 140                 


Ser Lys Leu Val Asp Trp Lys Asp Arg Asn Thr Cys Ile Leu Phe Gly 
145                 150                 155                 160 


Asp Gly Ser Gly Ala Ala Ile Leu Thr Glu Ser Asn Glu Lys Gly Ile 
                165                 170                 175     


Met Asn Val Tyr Leu Gly Ser Asp Gly Arg Gly Ala Asp Leu Leu Lys 
            180                 185                 190         


Cys Lys Ser Ser Ser Leu Thr Val Asn Ser Asp Glu Leu Lys Glu Leu 
        195                 200                 205             


Leu Asn Ser Lys Glu Glu Asp Leu Glu Asn Lys Phe Ile Glu Met Asp 
    210                 215                 220                 


Gly Lys Glu Ile Phe Lys Phe Ala Val Lys Val Met Ile Lys Gly Ile 
225                 230                 235                 240 


Glu Lys Val Leu Lys Asp Ser Asn Leu Glu Leu Lys Asp Ile Asn Tyr 
                245                 250                 255     


Ile Ile Pro His Gln Ala Asn Leu Arg Ile Ile Glu His Val Ala Lys 
            260                 265                 270         


Lys Leu Gly Ile Asp Glu Asn Lys Phe Tyr Ile Asn Ile Asn His Tyr 
        275                 280                 285             


Gly Asn Thr Ser Ala Ala Ser Ile Pro Ile Ala Leu Ala Glu Val Asp 
    290                 295                 300                 


Glu Lys Gly Leu Leu Lys Lys Gly Asp Asn Val Ile Leu Val Gly Phe 
305                 310                 315                 320 


Gly Ala Gly Leu Thr Trp Ala Ala Ser Leu Ile Lys Trp Ile 
                325                 330                 


<210>  16
<211>  329
<212>  PRT
<213>  Streptomyces sp. CL190

<400>  16

Met Thr Asp Val Arg Phe Arg Ile Ile Gly Thr Gly Ala Tyr Val Pro 
1               5                   10                  15      


Glu Arg Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp 
            20                  25                  30          


Asp Asp Trp Ile Thr Arg Lys Thr Gly Ile Arg Gln Arg Arg Trp Ala 
        35                  40                  45              


Ala Asp Asp Gln Ala Thr Ser Asp Leu Ala Thr Ala Ala Gly Arg Ala 
    50                  55                  60                  


Ala Leu Lys Ala Ala Gly Ile Thr Pro Glu Gln Leu Thr Val Ile Ala 
65                  70                  75                  80  


Val Ala Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr 
                85                  90                  95      


Val Gln His His Leu Gly Ala Thr Gly Thr Ala Ala Phe Asp Val Asn 
            100                 105                 110         


Ala Val Cys Ser Gly Thr Val Phe Ala Leu Ser Ser Val Ala Gly Thr 
        115                 120                 125             


Leu Val Tyr Arg Gly Gly Tyr Ala Leu Val Ile Gly Ala Asp Leu Tyr 
    130                 135                 140                 


Ser Arg Ile Leu Asn Pro Ala Asp Arg Lys Thr Val Val Leu Phe Gly 
145                 150                 155                 160 


Asp Gly Ala Gly Ala Met Val Leu Gly Pro Thr Ser Thr Gly Thr Gly 
                165                 170                 175     


Pro Ile Val Arg Arg Val Ala Leu His Thr Phe Gly Gly Leu Thr Asp 
            180                 185                 190         


Leu Ile Arg Val Pro Ala Gly Gly Ser Arg Gln Pro Leu Asp Thr Asp 
        195                 200                 205             


Gly Leu Asp Ala Gly Leu Gln Tyr Phe Ala Met Asp Gly Arg Glu Val 
    210                 215                 220                 


Arg Arg Phe Val Thr Glu His Leu Pro Gln Leu Ile Lys Gly Phe Leu 
225                 230                 235                 240 


His Glu Ala Gly Val Asp Ala Ala Asp Ile Ser His Phe Val Pro His 
                245                 250                 255     


Gln Ala Asn Gly Val Met Leu Asp Glu Val Phe Gly Glu Leu His Leu 
            260                 265                 270         


Pro Arg Ala Thr Met His Arg Thr Val Glu Thr Tyr Gly Asn Thr Gly 
        275                 280                 285             


Ala Ala Ser Ile Pro Ile Thr Met Asp Ala Ala Val Arg Ala Gly Ser 
    290                 295                 300                 


Phe Arg Pro Gly Glu Leu Val Leu Leu Ala Gly Phe Gly Gly Gly Met 
305                 310                 315                 320 


Ala Ala Ser Phe Ala Leu Ile Glu Trp 
                325                 


<210>  17
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of NphT7 from Streptomyces sp. CL190

<400>  17

Met Thr Asp Val Arg Phe Arg Ile Ile Gly Thr Gly Ala Tyr Val Pro 
1               5                   10                  15      


Glu Arg Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp 
            20                  25                  30          


Asp Asp Trp Ile Thr Arg Lys Thr Gly Ile Arg Gln Arg Arg Trp Ala 
        35                  40                  45              


Ala Asp Asp Gln Ala Thr Ser Asp Leu Ala Thr Ala Ala Gly Arg Ala 
    50                  55                  60                  


Ala Leu Lys Ala Ala Gly Ile Thr Pro Glu Gln Leu Thr Val Ile Ala 
65                  70                  75                  80  


Val Ala Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr 
                85                  90                  95      


Val Gln His His Leu Gly Ala Thr Gly Thr Ala Ala Phe Asp Val Asn 
            100                 105                 110         


Ala Val Cys Ser Gly Thr Val Phe Ala Leu Ser Ser Val Ala Gly Thr 
        115                 120                 125             


Leu Val Tyr Arg Gly Gly Tyr Ala Leu Val Ile Gly Ala Asp Leu Tyr 
    130                 135                 140                 


Ser Arg Ser Leu Asn Pro Ala Asp Arg Lys Thr Val Val Leu Phe Gly 
145                 150                 155                 160 


Asp Gly Ala Gly Ala Met Val Leu Gly Pro Thr Ser Thr Gly Thr Gly 
                165                 170                 175     


Pro Ile Val Arg Arg Val Ala Leu His Thr Phe Gly Gly Leu Thr Asp 
            180                 185                 190         


Leu Ile Arg Val Pro Ala Gly Gly Ser Arg Gln Pro Leu Asp Thr Asp 
        195                 200                 205             


Gly Leu Asp Ala Gly Leu Gln Tyr Val Ala Met Asp Gly Arg Glu Val 
    210                 215                 220                 


Arg Arg Phe Val Thr Glu His Leu Pro Gln Leu Ile Lys Gly Phe Leu 
225                 230                 235                 240 


His Glu Ala Gly Val Asp Ala Ala Asp Ile Ser His Phe Val Pro His 
                245                 250                 255     


Gln Ala Asn Gly Val Met Leu Asp Glu Val Phe Gly Glu Leu His Leu 
            260                 265                 270         


Pro Arg Ala Thr Met His Arg Thr Val Glu Thr Tyr Gly Asn Thr Gly 
        275                 280                 285             


Ala Ala Ser Ile Pro Ile Thr Met Asp Ala Ala Val Arg Ala Gly Ser 
    290                 295                 300                 


Phe Arg Pro Gly Glu Leu Val Leu Leu Ala Gly Phe Gly Gly Gly Met 
305                 310                 315                 320 


Ala Ala Ser Phe Ala Leu Ile Glu Trp 
                325                 


<210>  18
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Asch from Acinetobacter schindleri CIP 107287

<400>  18

Met Gly Ile Arg Ile Thr Gly Thr Gly Leu Phe His Pro Thr Asp Phe 
1               5                   10                  15      


Ile Thr Asn Glu Glu Leu Val Glu Ser Leu Asn Ala Tyr Val Glu Gln 
            20                  25                  30          


Tyr Asn Leu Glu Asn Ala Asp Lys Ile Ala Ala Gly Glu Ile Glu Glu 
        35                  40                  45              


Leu Arg Gly Ser Ser Ala Glu Phe Ile Glu Lys Ala Ser Gly Ile Lys 
    50                  55                  60                  


Arg Arg Tyr Val Ala Glu Lys Thr Gly Ile Leu Asp Pro Lys Arg Leu 
65                  70                  75                  80  


Arg Pro Leu Leu His Glu Arg Ser Asn Asp Glu Leu Ser Ile Gln Ala 
                85                  90                  95      


Glu Trp Gly Val Ala Ala Ala Lys Gln Ala Met Glu Asn Ala Gly Val 
            100                 105                 110         


Thr Ala Glu Asp Ile Asp Val Val Ile Leu Ser Cys Ser Asn Ile Gln 
        115                 120                 125             


Arg Ala Tyr Pro Ala Leu Ala Ile Glu Ile Gln Thr Ala Leu Gly Ile 
    130                 135                 140                 


Gln Gly Tyr Ala Tyr Asp Met Asn Val Ala Cys Ser Ala Ala Thr Phe 
145                 150                 155                 160 


Gly Ile Lys Gln Ala Ala Asp Ala Ile Lys Ser Gly Ala Arg Arg Val 
                165                 170                 175     


Leu Met Val Asn Val Glu Ile Thr Ser Gly His Thr Asp Phe Arg Ser 
            180                 185                 190         


Arg Asp Cys His Phe Ile Phe Gly Asp Val Ala Thr Ala Ser Ile Ile 
        195                 200                 205             


Glu Glu Thr Glu Thr Lys Thr Gly Phe Glu Ile Glu Asp Ile Glu Leu 
    210                 215                 220                 


Phe Thr Gln Phe Ser Asn Asn Ile Arg Asn Asn Phe Gly Tyr Leu Asn 
225                 230                 235                 240 


Leu Ser Glu Val Asp Ala Asp Ile Asp Asn Asn Arg Phe Arg Gln Asp 
                245                 250                 255     


Gly Arg Lys Val Phe Lys Glu Val Cys Pro Leu Val Ala Lys Met Ile 
            260                 265                 270         


Thr Lys Gln Leu Glu Lys Asn Gln Ile Glu Pro Thr Asn Val Lys Arg 
        275                 280                 285             


Phe Trp Leu His Gln Ala Asn Ala Asn Met Asn Glu Leu Ile Leu Lys 
    290                 295                 300                 


Leu Ile Val Gly Lys Glu His Ala Lys Ser Glu Leu Val Pro Leu Ile 
305                 310                 315                 320 


Leu Asp Glu Phe Ala Asn Thr Ser Ser Ala Gly Val Ile Ile Ala Leu 
                325                 330                 335     


His Arg Thr Ala Asn Glu Val Asn Asp Gly Glu Tyr Gly Val Leu Cys 
            340                 345                 350         


Ser Phe Gly Ala Gly Tyr Ser Val Gly Ser Ile Leu Val Lys Lys His 
        355                 360                 365             


Val Ala 
    370 


<210>  19
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Asch from Acinetobacter schindleri CIP 107287

<400>  19

Met Gly Ile Arg Ile Thr Gly Thr Gly Leu Phe His Pro Thr Asp Phe 
1               5                   10                  15      


Ile Thr Asn Glu Glu Leu Val Glu Ser Leu Asn Ala Tyr Val Glu Gln 
            20                  25                  30          


Tyr Asn Leu Glu Asn Ala Asp Lys Ile Ala Ala Gly Glu Ile Glu Glu 
        35                  40                  45              


Leu Arg Gly Ser Ser Ala Glu Phe Ile Glu Lys Ala Ser Gly Ile Lys 
    50                  55                  60                  


Arg Arg Tyr Val Ala Glu Lys Thr Gly Ile Leu Asp Pro Lys Arg Leu 
65                  70                  75                  80  


Arg Pro Leu Leu His Glu Arg Ser Asn Asp Glu Leu Ser Ile Gln Ala 
                85                  90                  95      


Glu Trp Gly Val Ala Ala Ala Lys Gln Ala Met Glu Asn Ala Gly Val 
            100                 105                 110         


Thr Ala Glu Asp Ile Asp Val Val Ile Leu Ser Cys Ser Asn Ile Gln 
        115                 120                 125             


Arg Ala Tyr Pro Ala Leu Ala Ile Glu Ile Gln Thr Ala Leu Gly Ile 
    130                 135                 140                 


Gln Gly Tyr Ala Tyr Asp Met Asn Val Ala Cys Ser Ala Ala Thr Phe 
145                 150                 155                 160 


Gly Ile Lys Gln Ala Ala Asp Ala Ile Lys Ser Gly Ala Arg Arg Val 
                165                 170                 175     


Leu Met Val Asn Val Glu Ile Ile Ser Gly His Thr Asp Phe Arg Ser 
            180                 185                 190         


Arg Asp Cys His Phe Ile Phe Gly Asp Val Ala Thr Ala Ser Ile Ile 
        195                 200                 205             


Glu Glu Thr Glu Thr Lys Thr Gly Phe Glu Ile Glu Asp Ile Glu Leu 
    210                 215                 220                 


Phe Thr Gln Phe Ser Asn Asn Ile Arg Asn Asn Leu Gly Tyr Leu Asn 
225                 230                 235                 240 


Leu Ser Glu Val Asp Ala Asp Ile Asp Asn Asn Arg Phe Arg Gln Asp 
                245                 250                 255     


Gly Arg Lys Val Phe Lys Glu Val Cys Pro Leu Ala Ala Lys Met Ile 
            260                 265                 270         


Thr Lys Gln Leu Glu Lys Asn Gln Ile Glu Pro Thr Asn Val Lys Arg 
        275                 280                 285             


Phe Trp Leu His Gln Ala Asn Ala Asn Met Asn Glu Leu Ile Leu Lys 
    290                 295                 300                 


Leu Ile Val Gly Lys Glu His Ala Lys Ser Glu Leu Ala Pro Leu Ile 
305                 310                 315                 320 


Leu Asp Glu Phe Ala Asn Thr Gly Ser Ala Gly Val Ile Ile Ala Leu 
                325                 330                 335     


His Arg Thr Ala Asn Glu Val Asn Asp Gly Glu Tyr Gly Val Leu Cys 
            340                 345                 350         


Ser Phe Gly Ala Gly Tyr Ser Val Gly Ser Ile Leu Val Lys Lys His 
        355                 360                 365             


Val Ala 
    370 


<210>  20
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Asch from Acinetobacter schindleri CIP 107287

<400>  20

Met Gly Ile Arg Ile Thr Gly Thr Gly Leu Phe His Pro Thr Asp Phe 
1               5                   10                  15      


Ile Thr Asn Glu Glu Leu Val Glu Ser Leu Asn Ala Tyr Val Glu Gln 
            20                  25                  30          


Tyr Asn Leu Glu Asn Ala Asp Lys Ile Ala Ala Gly Glu Ile Glu Glu 
        35                  40                  45              


Leu Arg Gly Ser Ser Ala Glu Phe Ile Glu Lys Ala Ser Gly Ile Lys 
    50                  55                  60                  


Arg Arg Tyr Val Ala Glu Lys Thr Gly Ile Leu Asp Pro Lys Arg Leu 
65                  70                  75                  80  


Arg Pro Leu Leu His Glu Arg Ser Asn Asp Glu Leu Ser Ile Gln Ala 
                85                  90                  95      


Glu Trp Gly Val Ala Ala Ala Lys Gln Ala Met Glu Asn Ala Gly Val 
            100                 105                 110         


Thr Ala Glu Asp Ile Asp Val Val Ile Leu Ser Cys Ser Asn Ile Gln 
        115                 120                 125             


Arg Ala Tyr Pro Ala Leu Ala Ile Glu Ile Gln Thr Ala Leu Gly Ile 
    130                 135                 140                 


Gln Gly Tyr Ala Tyr Asp Met Asn Val Ala Cys Ser Ala Ala Thr Phe 
145                 150                 155                 160 


Gly Ile Lys Gln Ala Ala Asp Ala Ile Lys Ser Gly Ala Arg Arg Val 
                165                 170                 175     


Leu Met Val Asn Val Glu Ile Ile Ser Gly His Thr Asp Phe Arg Ser 
            180                 185                 190         


Arg Asp Cys His Phe Ile Phe Gly Asp Val Ala Thr Ala Ser Ile Ile 
        195                 200                 205             


Glu Glu Thr Glu Thr Lys Thr Gly Phe Glu Ile Glu Asp Ile Glu Leu 
    210                 215                 220                 


Phe Thr Gln Phe Ser Asn Asn Ile Arg Asn Asn Phe Gly Tyr Leu Asn 
225                 230                 235                 240 


Leu Ser Glu Val Asp Ala Asp Ile Asp Asn Asn Arg Phe Arg Gln Asp 
                245                 250                 255     


Gly Arg Lys Val Phe Lys Glu Val Cys Pro Leu Val Ala Lys Met Ile 
            260                 265                 270         


Thr Lys Gln Leu Glu Lys Asn Gln Ile Glu Pro Thr Asn Val Lys Arg 
        275                 280                 285             


Phe Trp Leu His Gln Ala Asn Val Asn Met Asn Glu Leu Ile Leu Lys 
    290                 295                 300                 


Leu Ile Val Gly Lys Glu His Ala Lys Ser Glu Leu Val Pro Leu Ile 
305                 310                 315                 320 


Leu Asp Glu Phe Ala Asn Thr Ser Ser Ala Gly Val Ile Ile Ala Leu 
                325                 330                 335     


His Arg Thr Ala Asn Glu Val Asn Asp Gly Glu Tyr Gly Val Leu Cys 
            340                 345                 350         


Ser Phe Gly Ala Gly Tyr Ser Val Gly Ser Ile Leu Val Lys Lys His 
        355                 360                 365             


Val Ala 
    370 


<210>  21
<211>  317
<212>  PRT
<213>  Escherichia coli

<400>  21

Met Tyr Thr Lys Ile Ile Gly Thr Gly Ser Tyr Leu Pro Glu Gln Val 
1               5                   10                  15      


Arg Thr Asn Ala Asp Leu Glu Lys Met Val Asp Thr Ser Asp Glu Trp 
            20                  25                  30          


Ile Val Thr Arg Thr Gly Ile Arg Glu Arg His Ile Ala Ala Pro Asn 
        35                  40                  45              


Glu Thr Val Ser Thr Met Gly Phe Glu Ala Ala Thr Arg Ala Ile Glu 
    50                  55                  60                  


Met Ala Gly Ile Glu Lys Asp Gln Ile Gly Leu Ile Val Val Ala Thr 
65                  70                  75                  80  


Thr Ser Ala Thr His Ala Phe Pro Ser Ala Ala Cys Gln Ile Gln Ser 
                85                  90                  95      


Met Leu Gly Ile Lys Gly Cys Pro Ala Phe Asp Val Ala Ala Ala Cys 
            100                 105                 110         


Ala Gly Phe Thr Tyr Ala Leu Ser Val Ala Asp Gln Tyr Val Lys Ser 
        115                 120                 125             


Gly Ala Val Lys Tyr Ala Leu Val Val Gly Ser Asp Val Leu Ala Arg 
    130                 135                 140                 


Thr Cys Asp Pro Thr Asp Arg Gly Thr Ile Ile Ile Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Ala Val Leu Ala Ala Ser Glu Glu Pro Gly Ile Ile Ser 
                165                 170                 175     


Thr His Leu His Ala Asp Gly Ser Tyr Gly Glu Leu Leu Thr Leu Pro 
            180                 185                 190         


Asn Ala Asp Arg Val Asn Pro Glu Asn Ser Ile His Leu Thr Met Ala 
        195                 200                 205             


Gly Asn Glu Val Phe Lys Val Ala Val Thr Glu Leu Ala His Ile Val 
    210                 215                 220                 


Asp Glu Thr Leu Ala Ala Asn Asn Leu Asp Arg Ser Gln Leu Asp Trp 
225                 230                 235                 240 


Leu Val Pro His Gln Ala Asn Leu Arg Ile Ile Ser Ala Thr Ala Lys 
                245                 250                 255     


Lys Leu Gly Met Ser Met Asp Asn Val Val Val Thr Leu Asp Arg His 
            260                 265                 270         


Gly Asn Thr Ser Ala Ala Ser Val Pro Cys Ala Leu Asp Glu Ala Val 
        275                 280                 285             


Arg Asp Gly Arg Ile Lys Pro Gly Gln Leu Val Leu Leu Glu Ala Phe 
    290                 295                 300                 


Gly Gly Gly Phe Thr Trp Gly Ser Ala Leu Val Arg Phe 
305                 310                 315         


<210>  22
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Asch from Acinetobacter schindleri CIP 107287

<400>  22

Met Gly Ile Arg Ile Thr Gly Thr Gly Leu Phe His Pro Thr Asp Phe 
1               5                   10                  15      


Ile Thr Asn Glu Glu Leu Val Glu Ser Leu Asn Ala Tyr Val Glu Gln 
            20                  25                  30          


Tyr Asn Leu Glu Asn Ala Asp Lys Ile Ala Ala Gly Glu Ile Glu Glu 
        35                  40                  45              


Leu Arg Gly Ser Ser Ala Glu Phe Ile Glu Lys Ala Ser Gly Ile Lys 
    50                  55                  60                  


Arg Arg Tyr Val Ala Glu Lys Thr Gly Ile Leu Asp Pro Lys Arg Leu 
65                  70                  75                  80  


Arg Pro Leu Leu His Glu Arg Ser Asn Asp Glu Leu Ser Ile Gln Ala 
                85                  90                  95      


Glu Trp Gly Val Ala Ala Ala Lys Gln Ala Met Glu Asn Ala Gly Val 
            100                 105                 110         


Thr Ala Glu Asp Ile Asp Val Val Ile Leu Ser Cys Ser Asn Ile Gln 
        115                 120                 125             


Arg Ala Tyr Pro Ala Leu Ala Ile Glu Ile Gln Thr Ala Leu Gly Ile 
    130                 135                 140                 


Gln Gly Tyr Ala Tyr Asp Met Asn Val Ala Cys Ser Ala Ala Thr Phe 
145                 150                 155                 160 


Gly Ile Lys Gln Ala Ala Asp Ala Ile Lys Ser Gly Ala Arg Arg Val 
                165                 170                 175     


Leu Met Val Asn Val Glu Ile Ile Ser Gly His Thr Asp Phe Arg Ser 
            180                 185                 190         


Arg Asp Cys His Phe Ile Phe Gly Asp Val Ala Thr Ala Ser Ile Ile 
        195                 200                 205             


Glu Glu Thr Glu Thr Lys Thr Gly Phe Glu Ile Glu Asp Ile Glu Leu 
    210                 215                 220                 


Phe Thr Gln Phe Ser Asn Asn Ile Arg Asn Asn Phe Gly Tyr Leu Asn 
225                 230                 235                 240 


Leu Ser Glu Val Asp Ala Asp Ile Asp Asn Asn Arg Phe Arg Gln Asp 
                245                 250                 255     


Gly Arg Lys Val Phe Lys Glu Val Cys Pro Leu Ala Ala Lys Met Ile 
            260                 265                 270         


Thr Lys Gln Leu Glu Lys Asn Gln Ile Glu Pro Thr Asn Val Lys Arg 
        275                 280                 285             


Phe Trp Leu His Gln Ala Asn Ala Asn Met Asn Glu Leu Ile Leu Lys 
    290                 295                 300                 


Leu Ile Val Gly Lys Glu His Ala Lys Ser Glu Leu Val Pro Leu Ile 
305                 310                 315                 320 


Leu Asp Glu Phe Ala Asn Thr Ser Ser Ala Gly Val Ile Ile Ala Leu 
                325                 330                 335     


His Arg Thr Ala Asn Glu Val Asn Asp Gly Glu Tyr Gly Val Leu Cys 
            340                 345                 350         


Ser Phe Gly Ala Gly Tyr Ser Val Gly Ser Ile Leu Val Lys Lys His 
        355                 360                 365             


Val Ala 
    370 


<210>  23
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Sko3 from Streptomyces sp. KO-3988

<400>  23

Met Thr Asp Leu Arg Ile Leu Gly Thr Gly Ala Tyr Val Pro Glu Arg 
1               5                   10                  15      


Ile Ala Ser Asn Asp Glu Val Ala Ala Ala Ala Gly Val Asp Asp Ala 
            20                  25                  30          


Trp Ile Thr Ala Lys Thr Gly Ile Arg Glu Arg Arg Trp Ala Ala Asp 
        35                  40                  45              


Asp Gln Ala Thr Ser Asp Leu Ala Thr Ala Ala Gly Arg Ala Ala Leu 
    50                  55                  60                  


Arg Ser Ala Gly Ile Thr Ala Glu Asp Leu Ser Val Ile Val Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr Val Gln 
                85                  90                  95      


Gln Arg Leu Gly Ala Ser Asp Ala Ala Ala Phe Asp Val Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Met Val Phe Ala Leu Ala Ala Ala Glu Gly Val Leu Thr 
        115                 120                 125             


Arg Thr Gly Gly His Ala Leu Val Ile Gly Ala Asp Leu Tyr Ser Arg 
    130                 135                 140                 


Ser Leu Asn Arg Ala Asp Arg Arg Thr Val Ile Leu Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Val Ile Leu Gly Ser Ser Val Asp His Gly Pro Arg Ile 
                165                 170                 175     


Arg His Leu Ala Leu His Ser Phe Gly Glu Leu Ser Gly Leu Ile Glu 
            180                 185                 190         


Val Pro Ala Gly Gly Ser Arg Met Pro Val Asp Gln Thr Val Leu Asp 
        195                 200                 205             


Ala Gly Leu Gln Tyr Val Ala Met Asp Gly Arg Gly Val Arg Asn Phe 
    210                 215                 220                 


Val Cys Asp His Leu Pro Gln Leu Val Lys Gly Phe Leu His Lys Cys 
225                 230                 235                 240 


Gly Val Val Pro Asp Asp Ile Asp His Phe Val Pro His Gln Ala Asn 
                245                 250                 255     


Gly Thr Met Leu Asp Ser Leu Phe Ala Asp Leu Glu Leu Pro Arg Ala 
            260                 265                 270         


Thr Met His Arg Thr Leu Thr His Tyr Ala Asn Thr Gly Ala Ala Ser 
        275                 280                 285             


Ile Pro Ile Thr Leu Asp Ala Ala Ala Arg Ala Gly Ala Phe Asn Pro 
    290                 295                 300                 


Gly Asp Leu Ile Leu Met Ala Gly Phe Gly Gly Gly Met Ser Ala Gly 
305                 310                 315                 320 


Phe Ala Leu Val Glu Trp 
                325     


<210>  24
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Sten from Streptomyces tendae

<400>  24

Met Ser Asp Val Arg Ile Leu Gly Thr Gly Ala Tyr Val Pro Asp Arg 
1               5                   10                  15      


Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp Asp Ala 
            20                  25                  30          


Trp Ile Thr Ala Lys Thr Ala Ile Arg Glu Arg Arg Trp Ala Ala Thr 
        35                  40                  45              


His Gln Ala Thr Ser Asp Leu Ala Thr Gln Ala Ala Arg Asn Ala Leu 
    50                  55                  60                  


Asp Cys Ala Gly Ile Thr Ala Ala Glu Leu Thr Val Ile Ile Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr Val Gln 
                85                  90                  95      


His Asn Leu Ala Ala Thr His Ala Ala Ala Phe Asp Ile Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Glu Ile Phe Ala Leu Ser Ala Ala Glu Gly Thr Leu Ala 
        115                 120                 125             


Arg Lys Gly Gly His Ala Leu Ile Ile Gly Ala Asp Leu Tyr Ser Arg 
    130                 135                 140                 


Ser Leu Asn Pro Thr Asp Arg Lys Thr Thr Val Leu Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Met Ile Leu Gly Pro Ala Thr Thr Gly Pro Arg Ile Arg 
                165                 170                 175     


His Leu Thr Leu His Thr Tyr Gly Glu His Ser Asp Leu Ile Gln Val 
            180                 185                 190         


Pro Ala Gly Gly Ser Arg Leu Pro Thr Thr Thr Gln Thr Leu Gln Gln 
        195                 200                 205             


Asp Gln His Tyr Val Thr Met Asp Gly Arg Gly Val Arg Arg Phe Val 
    210                 215                 220                 


Ala Asp His Leu Pro Arg Leu Thr Lys Glu Phe Leu His Glu Ala Gly 
225                 230                 235                 240 


Thr Val Pro Asp Asp Ile Arg His Phe Ile Pro His Gln Ala Asn Gly 
                245                 250                 255     


Val Met Leu Asp Asp Leu Phe Thr Gln Leu Ala Leu Pro His Ala Thr 
            260                 265                 270         


Met His Gln Thr Leu Thr Thr Tyr Ala Asn Thr Gly Ala Ala Ser Ile 
        275                 280                 285             


Pro Leu Thr Leu Asp Thr Ala His Arg Asn Asn Ala Leu His Pro Gly 
    290                 295                 300                 


Asp Leu Ile Leu Leu Ala Gly Phe Gly Gly Gly Met Ala Ala Gly Leu 
305                 310                 315                 320 


Ala Leu Ile Glu Trp 
                325 


<210>  25
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Nbra from Nocardia brasiliensis ATCC 700358

<400>  25

Met Asn Asn Ile Ala Val Leu Gly Thr Gly Ser Tyr Leu Pro Asp Arg 
1               5                   10                  15      


Ile Val Ser Asn Ser Glu Val Gly Ser Gly Ala Asp Val Asp Ser Glu 
            20                  25                  30          


Trp Ile Ile Arg Lys Thr Ala Ile Arg Glu Arg Arg Trp Ala Leu Pro 
        35                  40                  45              


Asp Gln Ala Thr Ser Asp Leu Ala Thr His Ala Ala Ser Ala Ala Leu 
    50                  55                  60                  


Asp Ala Ala Gly Ile Ser Ala Asp Glu Val Ser Ala Ile Val Val Ala 
65                  70                  75                  80  


Thr Ser Thr Pro Asp His Pro Gln Pro Pro Thr Ala Ala Phe Val Gln 
                85                  90                  95      


His Asn Leu Gly Ala Arg Gly Ala Ser Ala Phe Asp Val Asn Ala Val 
            100                 105                 110         


Cys Ser Gly Phe Val Phe Ala Leu Ser Ala Val Glu Ala Ala Ile Ala 
        115                 120                 125             


Arg Ala Gly Gly Gly Tyr Gly Leu Val Val Gly Ala Asp Val Tyr Ser 
    130                 135                 140                 


Arg Ser Leu Asn Pro Ala Asp Arg Arg Thr Val Val Leu Phe Gly Asp 
145                 150                 155                 160 


Gly Ala Gly Ala Val Val Leu Gly Pro Ser Ala Ser Gly Gly Leu Arg 
                165                 170                 175     


Arg Phe Gly Leu His Thr Phe Gly Asp Leu Thr Ser Leu Ile Arg Val 
            180                 185                 190         


Pro Ala Gly Gly Ser Arg Gln Pro Tyr Asp Pro Ala Ala His Glu Leu 
        195                 200                 205             


Gly Ala Gln Tyr Val Thr Met Asp Gly Arg Gly Val Arg Ala Phe Val 
    210                 215                 220                 


Asn Gly Ser Leu Pro Val Leu Val Lys Gln Phe Leu His Asp Ser Gly 
225                 230                 235                 240 


Val Ala Pro Asp Asp Ile Thr His Leu Ile Pro His Gln Ala Asn Gly 
                245                 250                 255     


Val Met Leu Ala Glu Leu Ala Glu Glu Leu Gly Leu Val Asn Ala Thr 
            260                 265                 270         


Met His Thr Thr Val Arg Tyr Tyr Gly Asn Thr Gly Ala Ala Ser Ile 
        275                 280                 285             


Pro Ile Thr Leu Asp Asn Ala Ala Arg Thr Gly Gly Ile Arg Pro Gly 
    290                 295                 300                 


Asp Thr Val Leu Leu Val Gly Phe Gly Gly Gly Met Ala Val Gly Leu 
305                 310                 315                 320 


Thr Leu Val Glu Trp 
                325 


<210>  26
<211>  370
<212>  PRT
<213>  Acinetobacter schindleri CIP 107287

<400>  26

Met Gly Ile Arg Ile Thr Gly Thr Gly Leu Phe His Pro Thr Asp Phe 
1               5                   10                  15      


Ile Thr Asn Glu Glu Leu Val Glu Ser Leu Asn Ala Tyr Val Glu Gln 
            20                  25                  30          


Tyr Asn Leu Glu Asn Ala Asp Lys Ile Ala Ala Gly Glu Ile Glu Glu 
        35                  40                  45              


Leu Arg Gly Ser Ser Ala Glu Phe Ile Glu Lys Ala Ser Gly Ile Lys 
    50                  55                  60                  


Arg Arg Tyr Val Ala Glu Lys Thr Gly Ile Leu Asp Pro Lys Arg Leu 
65                  70                  75                  80  


Arg Pro Leu Leu His Glu Arg Ser Asn Asp Glu Leu Ser Ile Gln Ala 
                85                  90                  95      


Glu Trp Gly Val Ala Ala Ala Lys Gln Ala Met Glu Asn Ala Gly Val 
            100                 105                 110         


Thr Ala Glu Asp Ile Asp Val Val Ile Leu Ser Cys Ser Asn Ile Gln 
        115                 120                 125             


Arg Ala Tyr Pro Ala Leu Ala Ile Glu Ile Gln Thr Ala Leu Gly Ile 
    130                 135                 140                 


Gln Gly Tyr Ala Tyr Asp Met Asn Val Ala Cys Ser Ala Ala Thr Phe 
145                 150                 155                 160 


Gly Ile Lys Gln Ala Ala Asp Ala Ile Lys Ser Gly Ala Arg Arg Val 
                165                 170                 175     


Leu Met Val Asn Val Glu Ile Thr Ser Gly His Thr Asp Phe Arg Ser 
            180                 185                 190         


Arg Asp Cys His Phe Ile Phe Gly Asp Val Ala Thr Ala Ser Ile Ile 
        195                 200                 205             


Glu Glu Thr Glu Thr Lys Thr Gly Phe Glu Ile Glu Asp Ile Glu Leu 
    210                 215                 220                 


Phe Thr Gln Phe Ser Asn Asn Ile Arg Asn Asn Phe Gly Tyr Leu Asn 
225                 230                 235                 240 


Leu Ser Glu Val Asp Ala Asp Ile Asp Asn Asn Arg Phe Arg Gln Asp 
                245                 250                 255     


Gly Arg Lys Val Phe Lys Glu Val Cys Pro Leu Val Ala Lys Met Ile 
            260                 265                 270         


Thr Lys Gln Leu Glu Lys Asn Gln Ile Glu Pro Thr Asn Val Lys Arg 
        275                 280                 285             


Phe Trp Leu His Gln Ala Asn Val Asn Met Asn Glu Leu Ile Leu Lys 
    290                 295                 300                 


Leu Ile Val Gly Lys Glu His Ala Lys Ser Glu Leu Val Pro Leu Ile 
305                 310                 315                 320 


Leu Asp Glu Phe Ala Asn Thr Ser Ser Ala Gly Val Ile Ile Ala Leu 
                325                 330                 335     


His Arg Thr Ala Asn Glu Val Asn Asp Gly Glu Tyr Gly Val Leu Cys 
            340                 345                 350         


Ser Phe Gly Ala Gly Tyr Ser Val Gly Ser Ile Leu Val Lys Lys His 
        355                 360                 365             


Val Ala 
    370 


<210>  27
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Scin from Streptomyces cinnamonensis

<400>  27

Met Thr Gly Ile Ala Ala Asp Ile Ala Val Leu Gly Thr Gly Ala Tyr 
1               5                   10                  15      


Val Pro Asp Arg Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly 
            20                  25                  30          


Val Asp Gly Glu Trp Ile Val Arg Lys Thr Ala Ile Arg Glu Arg Arg 
        35                  40                  45              


Trp Ala Ala Pro Gly Gln Ala Thr Ser Asp Leu Ala Val Ala Ala Gly 
    50                  55                  60                  


Arg Ala Ala Leu Glu Ser Ala Gly Ile Thr Val Gly Gln Leu Ser Leu 
65                  70                  75                  80  


Ile Val Val Ala Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala 
                85                  90                  95      


Val Tyr Val Gln Gln Gln Leu Gly Ala Leu Gly Ala Ala Ala Phe Asp 
            100                 105                 110         


Val Asn Ala Val Cys Ser Gly Ser Val Phe Ala Leu Ser Val Val Glu 
        115                 120                 125             


Gly Met Leu Ala Arg Gln Gly Gly His Ala Leu Val Ile Gly Ala Asp 
    130                 135                 140                 


Val Tyr Ser Arg Ser Leu Asn Pro Ala Asp Arg Lys Thr Val Val Leu 
145                 150                 155                 160 


Phe Gly Asp Gly Ala Gly Ala Met Val Leu Gly Pro Ala Gly Gly Gly 
                165                 170                 175     


Arg Ala Ala Gly Ala Arg Val Arg His Val Thr Leu His Thr Val Gly 
            180                 185                 190         


Glu Leu Ala Gly Leu Ile Gln Val Pro Ala Gly Gly Ser Arg Gln Pro 
        195                 200                 205             


Ala Asp Gln Ala Val Leu Asp Ala Gly Leu Gln Tyr Val Ala Met Asp 
    210                 215                 220                 


Gly Arg Glu Val Arg Arg Phe Val Val Glu Gln Leu Pro Gln Leu Thr 
225                 230                 235                 240 


Lys Gln Phe Leu His Glu Ala Gly Val Val Pro Asp Asp Val Ala His 
                245                 250                 255     


Phe Val Pro His Gln Ala Asn Gly Val Met Leu Asp Thr Val Ile Glu 
            260                 265                 270         


Asp Leu Ala Leu Ser Arg Ala Thr Thr His Leu Thr Leu Glu Arg Tyr 
        275                 280                 285             


Gly Asn Thr Gly Ala Ala Ser Ile Pro Ile Thr Leu Asp Ala Ala Ala 
    290                 295                 300                 


Arg Glu Gly Ala Phe Arg Pro Gly Asp Leu Ile Leu Leu Ala Gly Phe 
305                 310                 315                 320 


Gly Gly Gly Met Ala Ala Gly Leu Ala Leu Leu Glu Trp 
                325                 330             


<210>  28
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of AccD and AccA from E. coli

<400>  28

Met Ser Trp Ile Glu Arg Ile Lys Ser Asn Ile Thr Pro Thr Arg Lys 
1               5                   10                  15      


Ala Ser Ile Pro Glu Gly Val Trp Thr Lys Cys Asp Ser Cys Gly Gln 
            20                  25                  30          


Val Leu Tyr Arg Ala Glu Leu Glu Arg Asn Leu Glu Val Cys Pro Lys 
        35                  40                  45              


Cys Asp His His Met Arg Met Thr Ala Arg Asn Arg Leu His Ser Leu 
    50                  55                  60                  


Leu Asp Glu Gly Ser Leu Val Glu Leu Gly Ser Glu Leu Glu Pro Lys 
65                  70                  75                  80  


Asp Val Leu Lys Phe Arg Asp Ser Lys Lys Tyr Lys Asp Arg Leu Ala 
                85                  90                  95      


Ser Ala Gln Lys Glu Thr Gly Glu Lys Asp Ala Leu Val Val Met Lys 
            100                 105                 110         


Gly Thr Leu Tyr Gly Met Pro Val Val Ala Ala Ala Phe Glu Phe Ala 
        115                 120                 125             


Phe Met Gly Gly Ser Met Gly Ser Val Val Gly Ala Arg Phe Val Arg 
    130                 135                 140                 


Ala Val Glu Gln Ala Leu Glu Asp Asn Cys Pro Leu Ile Cys Phe Ser 
145                 150                 155                 160 


Ala Ser Gly Gly Ala Arg Met Gln Glu Ala Leu Met Ser Leu Met Gln 
                165                 170                 175     


Met Ala Lys Thr Ser Ala Ala Leu Ala Lys Met Gln Glu Arg Gly Leu 
            180                 185                 190         


Pro Tyr Ile Ser Val Leu Thr Asp Pro Thr Met Gly Gly Val Ser Ala 
        195                 200                 205             


Ser Phe Ala Met Leu Gly Asp Leu Asn Ile Ala Glu Pro Lys Ala Leu 
    210                 215                 220                 


Ile Gly Phe Ala Gly Pro Arg Val Ile Glu Gln Thr Val Arg Glu Lys 
225                 230                 235                 240 


Leu Pro Pro Gly Phe Gln Arg Ser Glu Phe Leu Ile Glu Lys Gly Ala 
                245                 250                 255     


Ile Asp Met Ile Val Arg Arg Pro Glu Met Arg Leu Lys Leu Ala Ser 
            260                 265                 270         


Ile Leu Ala Lys Leu Met Asn Leu Pro Ala Pro Asn Pro Glu Ala Pro 
        275                 280                 285             


Arg Glu Gly Val Val Val Pro Pro Val Pro Asp Gln Glu Pro Glu Ala 
    290                 295                 300                 


Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Ala Ala Ser Leu Asn Phe Leu Asp Phe 
                325                 330                 335     


Glu Gln Pro Ile Ala Glu Leu Glu Ala Lys Ile Asp Ser Leu Thr Ala 
            340                 345                 350         


Val Ser Arg Gln Asp Glu Lys Leu Asp Ile Asn Ile Asp Glu Glu Val 
        355                 360                 365             


His Arg Leu Arg Glu Lys Ser Val Glu Leu Thr Arg Lys Ile Phe Ala 
    370                 375                 380                 


Asp Leu Gly Ala Trp Gln Ile Ala Gln Leu Ala Arg His Pro Gln Arg 
385                 390                 395                 400 


Pro Tyr Thr Leu Asp Tyr Val Arg Leu Ala Phe Asp Glu Phe Asp Glu 
                405                 410                 415     


Leu Ala Gly Asp Arg Ala Tyr Ala Asp Asp Lys Ala Ile Val Gly Gly 
            420                 425                 430         


Ile Ala Arg Leu Asp Gly Arg Pro Val Met Ile Ile Gly His Gln Lys 
        435                 440                 445             


Gly Arg Glu Thr Lys Glu Lys Ile Arg Arg Asn Phe Gly Met Pro Ala 
    450                 455                 460                 


Pro Glu Gly Tyr Arg Lys Ala Leu Arg Leu Met Gln Met Ala Glu Arg 
465                 470                 475                 480 


Phe Lys Met Pro Ile Ile Thr Phe Ile Asp Thr Pro Gly Ala Tyr Pro 
                485                 490                 495     


Gly Val Gly Ala Glu Glu Arg Gly Gln Ser Glu Ala Ile Ala Arg Asn 
            500                 505                 510         


Leu Arg Glu Met Ser Arg Leu Gly Val Pro Val Val Cys Thr Val Ile 
        515                 520                 525             


Gly Glu Gly Gly Ser Gly Gly Ala Leu Ala Ile Gly Val Gly Asp Lys 
    530                 535                 540                 


Val Asn Met Leu Gln Tyr Ser Thr Tyr Ser Val Ile Ser Pro Glu Gly 
545                 550                 555                 560 


Cys Ala Ser Ile Leu Trp Lys Ser Ala Asp Lys Ala Pro Leu Ala Ala 
                565                 570                 575     


Glu Ala Met Gly Ile Ile Ala Pro Arg Leu Lys Glu Leu Lys Leu Ile 
            580                 585                 590         


Asp Ser Ile Ile Pro Glu Pro Leu Gly Gly Ala His Arg Asn Pro Glu 
        595                 600                 605             


Ala Met Ala Ala Ser Leu Lys Ala Gln Leu Leu Ala Asp Leu Ala Asp 
    610                 615                 620                 


Leu Asp Val Leu Ser Thr Glu Asp Leu Lys Asn Arg Arg Tyr Gln Arg 
625                 630                 635                 640 


Leu Met Ser Tyr Gly Tyr Ala 
                645         


<210>  29
<211>  156
<212>  PRT
<213>  Escherichia coli

<400>  29

Met Asp Ile Arg Lys Ile Lys Lys Leu Ile Glu Leu Val Glu Glu Ser 
1               5                   10                  15      


Gly Ile Ser Glu Leu Glu Ile Ser Glu Gly Glu Glu Ser Val Arg Ile 
            20                  25                  30          


Ser Arg Ala Ala Pro Ala Ala Ser Phe Pro Val Met Gln Gln Ala Tyr 
        35                  40                  45              


Ala Ala Pro Met Met Gln Gln Pro Ala Gln Ser Asn Ala Ala Ala Pro 
    50                  55                  60                  


Ala Thr Val Pro Ser Met Glu Ala Pro Ala Ala Ala Glu Ile Ser Gly 
65                  70                  75                  80  


His Ile Val Arg Ser Pro Met Val Gly Thr Phe Tyr Arg Thr Pro Ser 
                85                  90                  95      


Pro Asp Ala Lys Ala Phe Ile Glu Val Gly Gln Lys Val Asn Val Gly 
            100                 105                 110         


Asp Thr Leu Cys Ile Val Glu Ala Met Lys Met Met Asn Gln Ile Glu 
        115                 120                 125             


Ala Asp Lys Ser Gly Thr Val Lys Ala Ile Leu Val Glu Ser Gly Gln 
    130                 135                 140                 


Pro Val Glu Phe Asp Glu Pro Leu Val Val Ile Glu 
145                 150                 155     


<210>  30
<211>  449
<212>  PRT
<213>  Escherichia coli

<400>  30

Met Leu Asp Lys Ile Val Ile Ala Asn Arg Gly Glu Ile Ala Leu Arg 
1               5                   10                  15      


Ile Leu Arg Ala Cys Lys Glu Leu Gly Ile Lys Thr Val Ala Val His 
            20                  25                  30          


Ser Ser Ala Asp Arg Asp Leu Lys His Val Leu Leu Ala Asp Glu Thr 
        35                  40                  45              


Val Cys Ile Gly Pro Ala Pro Ser Val Lys Ser Tyr Leu Asn Ile Pro 
    50                  55                  60                  


Ala Ile Ile Ser Ala Ala Glu Ile Thr Gly Ala Val Ala Ile His Pro 
65                  70                  75                  80  


Gly Tyr Gly Phe Leu Ser Glu Asn Ala Asn Phe Ala Glu Gln Val Glu 
                85                  90                  95      


Arg Ser Gly Phe Ile Phe Ile Gly Pro Lys Ala Glu Thr Ile Arg Leu 
            100                 105                 110         


Met Gly Asp Lys Val Ser Ala Ile Ala Ala Met Lys Lys Ala Gly Val 
        115                 120                 125             


Pro Cys Val Pro Gly Ser Asp Gly Pro Leu Gly Asp Asp Met Asp Lys 
    130                 135                 140                 


Asn Arg Ala Ile Ala Lys Arg Ile Gly Tyr Pro Val Ile Ile Lys Ala 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Arg Gly Met Arg Val Val Arg Gly Asp Ala 
                165                 170                 175     


Glu Leu Ala Gln Ser Ile Ser Met Thr Arg Ala Glu Ala Lys Ala Ala 
            180                 185                 190         


Phe Ser Asn Asp Met Val Tyr Met Glu Lys Tyr Leu Glu Asn Pro Arg 
        195                 200                 205             


His Val Glu Ile Gln Val Leu Ala Asp Gly Gln Gly Asn Ala Ile Tyr 
    210                 215                 220                 


Leu Ala Glu Arg Asp Cys Ser Met Gln Arg Arg His Gln Lys Val Val 
225                 230                 235                 240 


Glu Glu Ala Pro Ala Pro Gly Ile Thr Pro Glu Leu Arg Arg Tyr Ile 
                245                 250                 255     


Gly Glu Arg Cys Ala Lys Ala Cys Val Asp Ile Gly Tyr Arg Gly Ala 
            260                 265                 270         


Gly Thr Phe Glu Phe Leu Phe Glu Asn Gly Glu Phe Tyr Phe Ile Glu 
        275                 280                 285             


Met Asn Thr Arg Ile Gln Val Glu His Pro Val Thr Glu Met Ile Thr 
    290                 295                 300                 


Gly Val Asp Leu Ile Lys Glu Gln Leu Arg Ile Ala Ala Gly Gln Pro 
305                 310                 315                 320 


Leu Ser Ile Lys Gln Glu Glu Val His Val Arg Gly His Ala Val Glu 
                325                 330                 335     


Cys Arg Ile Asn Ala Glu Asp Pro Asn Thr Phe Leu Pro Ser Pro Gly 
            340                 345                 350         


Lys Ile Thr Arg Phe His Ala Pro Gly Gly Phe Gly Val Arg Trp Glu 
        355                 360                 365             


Ser His Ile Tyr Ala Gly Tyr Thr Val Pro Pro Tyr Tyr Asp Ser Met 
    370                 375                 380                 


Ile Gly Lys Leu Ile Cys Tyr Gly Glu Asn Arg Asp Val Ala Ile Ala 
385                 390                 395                 400 


Arg Met Lys Asn Ala Leu Gln Glu Leu Ile Ile Asp Gly Ile Lys Thr 
                405                 410                 415     


Asn Val Asp Leu Gln Ile Arg Ile Met Asn Asp Glu Asn Phe Gln His 
            420                 425                 430         


Gly Gly Thr Asn Ile His Tyr Leu Glu Lys Lys Leu Gly Leu Gln Glu 
        435                 440                 445             


Lys 
    


<210>  31
<211>  61
<212>  DNA
<213>  Escherichia coli

<400>  31
ggtttgaata aatgacaaaa agcaaagcct ttgtgccgat gaatctctat actgtttcac       60

a                                                                       61


<210>  32
<211>  60
<212>  DNA
<213>  Escherichia coli

<400>  32
gagttaacca cgcggcttgc caacggggtc tgaatcgctt tttttgtata taatgcgtgt       60


<210>  33
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of NphT7 from Streptomyces sp. CL190

<400>  33

Met Thr Asp Val Arg Phe Arg Ile Ile Gly Thr Gly Ala Tyr Val Pro 
1               5                   10                  15      


Glu Arg Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp 
            20                  25                  30          


Asp Asp Trp Ile Thr Arg Lys Thr Gly Ile Arg Gln Arg Arg Trp Ala 
        35                  40                  45              


Ala Asp Asp Gln Ala Thr Ser Asp Leu Ala Thr Ala Ala Gly Arg Ala 
    50                  55                  60                  


Ala Leu Lys Ala Ala Gly Ile Thr Pro Glu Gln Leu Thr Val Ile Ala 
65                  70                  75                  80  


Val Ala Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr 
                85                  90                  95      


Val Gln His Leu Leu Gly Ala Thr Gly Thr Ala Ala Phe Asp Val Asn 
            100                 105                 110         


Ala Val Cys Ser Gly Thr Val Phe Ala Leu Ser Ser Val Ala Gly Thr 
        115                 120                 125             


Leu Val Tyr Arg Gly Gly Tyr Ala Leu Val Ile Gly Ala Asp Leu Tyr 
    130                 135                 140                 


Ser Arg Ser Leu Asn Pro Ala Asp Arg Lys Thr Val Val Leu Phe Gly 
145                 150                 155                 160 


Asp Gly Ala Gly Ala Met Val Leu Gly Pro Thr Ser Thr Gly Thr Gly 
                165                 170                 175     


Pro Ile Val Arg Arg Val Ala Leu His Thr Phe Gly Gly Leu Thr Asp 
            180                 185                 190         


Leu Ile Arg Val Pro Ala Gly Gly Ser Arg Gln Pro Leu Asp Thr Asp 
        195                 200                 205             


Gly Leu Asp Ala Gly Leu Gln Tyr Val Ala Met Asp Gly Arg Glu Val 
    210                 215                 220                 


Arg Arg Phe Val Thr Glu His Leu Pro Gln Leu Ile Lys Gly Phe Leu 
225                 230                 235                 240 


His Glu Ala Gly Val Asp Ala Ala Asp Ile Ser His Phe Val Pro His 
                245                 250                 255     


Gln Ala Asn Gly Val Met Leu Asp Glu Val Phe Gly Glu Leu His Leu 
            260                 265                 270         


Pro Arg Ala Thr Met His Arg Thr Val Glu Thr Tyr Gly Asn Thr Gly 
        275                 280                 285             


Ala Ala Ser Ile Pro Ile Thr Met Asp Ala Ala Val Arg Ala Gly Ser 
    290                 295                 300                 


Phe Arg Pro Gly Glu Leu Val Leu Leu Ala Gly Phe Gly Gly Gly Met 
305                 310                 315                 320 


Ala Ala Ala Phe Ala Leu Ile Glu Trp 
                325                 


<210>  34
<211>  212
<212>  PRT
<213>  Treponema denticola

<400>  34

Met Ile Val Lys Pro Met Val Arg Asn Asn Ile Cys Leu Asn Ala His 
1               5                   10                  15      


Pro Gln Gly Cys Lys Lys Gly Val Glu Asp Gln Ile Glu Tyr Thr Lys 
            20                  25                  30          


Lys Arg Ile Thr Ala Glu Val Lys Ala Gly Ala Lys Ala Pro Lys Asn 
        35                  40                  45              


Val Leu Val Leu Gly Cys Ser Asn Gly Tyr Gly Leu Ala Ser Arg Ile 
    50                  55                  60                  


Thr Ala Ala Phe Gly Tyr Gly Ala Ala Thr Ile Gly Val Ser Phe Glu 
65                  70                  75                  80  


Lys Ala Gly Ser Glu Thr Lys Tyr Gly Thr Pro Gly Trp Tyr Asn Asn 
                85                  90                  95      


Leu Ala Phe Asp Glu Ala Ala Lys Arg Glu Gly Leu Tyr Ser Val Thr 
            100                 105                 110         


Ile Asp Gly Asp Ala Phe Ser Asp Glu Ile Lys Ala Gln Val Ile Glu 
        115                 120                 125             


Glu Ala Lys Lys Lys Gly Ile Lys Phe Asp Leu Ile Val Tyr Ser Leu 
    130                 135                 140                 


Ala Ser Pro Val Arg Thr Asp Pro Asp Thr Gly Ile Met His Lys Ser 
145                 150                 155                 160 


Val Leu Lys Pro Phe Gly Lys Thr Phe Thr Gly Lys Thr Val Asp Pro 
                165                 170                 175     


Phe Thr Gly Glu Leu Lys Glu Ile Ser Ala Glu Pro Ala Asn Asp Glu 
            180                 185                 190         


Glu Ala Ala Ala Thr Val Lys Val Met Gly Gly Glu Asp Trp Glu Val 
        195                 200                 205             


Gly Ser Asn Ser 
    210         


<210>  35
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of FabI from E. coli

<400>  35

Met Gly Phe Leu Ser Gly Lys Arg Ile Leu Val Thr Gly Val Ala Ser 
1               5                   10                  15      


Lys Leu Ser Ile Ala Tyr Gly Ile Ala Gln Ala Met His Arg Glu Gly 
            20                  25                  30          


Ala Glu Leu Ala Phe Thr Tyr Gln Asn Asp Lys Leu Lys Gly Arg Val 
        35                  40                  45              


Glu Glu Phe Ala Ala Gln Leu Gly Ser Asp Ile Val Leu Gln Cys Asp 
    50                  55                  60                  


Val Ala Glu Asp Ala Ser Ile Asp Thr Met Phe Ala Glu Leu Gly Lys 
65                  70                  75                  80  


Val Trp Pro Lys Phe Asp Gly Phe Val His Ser Ile Gly Phe Ala Pro 
                85                  90                  95      


Gly Asp Gln Leu Asp Gly Asp Tyr Val Asn Ala Val Thr Arg Glu Gly 
            100                 105                 110         


Phe Lys Ile Ala His Asp Ile Ser Ser Tyr Ser Phe Val Ala Met Ala 
        115                 120                 125             


Lys Ala Cys Arg Ser Met Leu Asn Pro Gly Ser Ala Leu Leu Thr Leu 
    130                 135                 140                 


Ser Tyr Leu Gly Ala Glu Arg Ala Ile Pro Asn Tyr Asn Val Met Gly 
145                 150                 155                 160 


Leu Ala Lys Ala Ser Leu Glu Ala Asn Val Arg Tyr Met Ala Asn Ala 
                165                 170                 175     


Met Gly Pro Glu Gly Val Arg Val Asn Ala Ile Ser Ala Gly Pro Ile 
            180                 185                 190         


Arg Thr Leu Ala Ala Ser Gly Ile Lys Asp Phe Arg Lys Met Leu Ala 
        195                 200                 205             


His Cys Glu Ala Val Thr Pro Ile Arg Arg Thr Val Thr Ile Glu Asp 
    210                 215                 220                 


Val Gly Asn Ser Ala Ala Phe Leu Cys Ser Asp Leu Ser Ala Gly Ile 
225                 230                 235                 240 


Phe Gly Glu Val Val His Val Asp Gly Gly Phe Ser Ile Ala Ala Met 
                245                 250                 255     


Asn Glu Leu Glu Leu Lys 
            260         


<210>  36
<211>  729
<212>  PRT
<213>  Escherichia coli

<400>  36

Met Val Tyr Lys Gly Asp Thr Leu Tyr Leu Asp Trp Leu Glu Asp Gly 
1               5                   10                  15      


Ile Ala Glu Leu Val Phe Asp Ala Pro Gly Ser Val Asn Lys Leu Asp 
            20                  25                  30          


Thr Ala Thr Val Ala Ser Leu Gly Glu Ala Ile Gly Val Leu Glu Gln 
        35                  40                  45              


Gln Ser Asp Leu Lys Gly Leu Leu Leu Arg Ser Asn Lys Ala Ala Phe 
    50                  55                  60                  


Ile Val Gly Ala Asp Ile Thr Glu Phe Leu Ser Leu Phe Leu Val Pro 
65                  70                  75                  80  


Glu Glu Gln Leu Ser Gln Trp Leu His Phe Ala Asn Ser Val Phe Asn 
                85                  90                  95      


Arg Leu Glu Asp Leu Pro Val Pro Thr Ile Ala Ala Val Asn Gly Tyr 
            100                 105                 110         


Ala Leu Gly Gly Gly Cys Glu Cys Val Leu Ala Thr Asp Tyr Arg Leu 
        115                 120                 125             


Ala Thr Pro Asp Leu Arg Ile Gly Leu Pro Glu Thr Lys Leu Gly Ile 
    130                 135                 140                 


Met Pro Gly Phe Gly Gly Ser Val Arg Met Pro Arg Met Leu Gly Ala 
145                 150                 155                 160 


Asp Ser Ala Leu Glu Ile Ile Ala Ala Gly Lys Asp Val Gly Ala Asp 
                165                 170                 175     


Gln Ala Leu Lys Ile Gly Leu Val Asp Gly Val Val Lys Ala Glu Lys 
            180                 185                 190         


Leu Val Glu Gly Ala Lys Ala Val Leu Arg Gln Ala Ile Asn Gly Asp 
        195                 200                 205             


Leu Asp Trp Lys Ala Lys Arg Gln Pro Lys Leu Glu Pro Leu Lys Leu 
    210                 215                 220                 


Ser Lys Ile Glu Ala Thr Met Ser Phe Thr Ile Ala Lys Gly Met Val 
225                 230                 235                 240 


Ala Gln Thr Ala Gly Lys His Tyr Pro Ala Pro Ile Thr Ala Val Lys 
                245                 250                 255     


Thr Ile Glu Ala Ala Ala Arg Phe Gly Arg Glu Glu Ala Leu Asn Leu 
            260                 265                 270         


Glu Asn Lys Ser Phe Val Pro Leu Ala His Thr Asn Glu Ala Arg Ala 
        275                 280                 285             


Leu Val Gly Ile Phe Leu Asn Asp Gln Tyr Val Lys Gly Lys Ala Lys 
    290                 295                 300                 


Lys Leu Thr Lys Asp Val Glu Thr Pro Lys Gln Ala Ala Val Leu Gly 
305                 310                 315                 320 


Ala Gly Ile Met Gly Gly Gly Ile Ala Tyr Gln Ser Ala Trp Lys Gly 
                325                 330                 335     


Val Pro Val Val Met Lys Asp Ile Asn Asp Lys Ser Leu Thr Leu Gly 
            340                 345                 350         


Met Thr Glu Ala Ala Lys Leu Leu Asn Lys Gln Leu Glu Arg Gly Lys 
        355                 360                 365             


Ile Asp Gly Leu Lys Leu Ala Gly Val Ile Ser Thr Ile His Pro Thr 
    370                 375                 380                 


Leu Asp Tyr Ala Gly Phe Asp Arg Val Asp Ile Val Val Glu Ala Val 
385                 390                 395                 400 


Val Glu Asn Pro Lys Val Lys Lys Ala Val Leu Ala Glu Thr Glu Gln 
                405                 410                 415     


Lys Val Arg Gln Asp Thr Val Leu Ala Ser Asn Thr Ser Thr Ile Pro 
            420                 425                 430         


Ile Ser Glu Leu Ala Asn Ala Leu Glu Arg Pro Glu Asn Phe Cys Gly 
        435                 440                 445             


Met His Phe Phe Asn Pro Val His Arg Met Pro Leu Val Glu Ile Ile 
    450                 455                 460                 


Arg Gly Glu Lys Ser Ser Asp Glu Thr Ile Ala Lys Val Val Ala Trp 
465                 470                 475                 480 


Ala Ser Lys Met Gly Lys Thr Pro Ile Val Val Asn Asp Cys Pro Gly 
                485                 490                 495     


Phe Phe Val Asn Arg Val Leu Phe Pro Tyr Phe Ala Gly Phe Ser Gln 
            500                 505                 510         


Leu Leu Arg Asp Gly Ala Asp Phe Arg Lys Ile Asp Lys Val Met Glu 
        515                 520                 525             


Lys Gln Phe Gly Trp Pro Met Gly Pro Ala Tyr Leu Leu Asp Val Val 
    530                 535                 540                 


Gly Ile Asp Thr Ala His His Ala Gln Ala Val Met Ala Ala Gly Phe 
545                 550                 555                 560 


Pro Gln Arg Met Gln Lys Asp Tyr Arg Asp Ala Ile Asp Ala Leu Phe 
                565                 570                 575     


Asp Ala Asn Arg Phe Gly Gln Lys Asn Gly Leu Gly Phe Trp Arg Tyr 
            580                 585                 590         


Lys Glu Asp Ser Lys Gly Lys Pro Lys Lys Glu Glu Asp Ala Ala Val 
        595                 600                 605             


Glu Asp Leu Leu Ala Glu Val Ser Gln Pro Lys Arg Asp Phe Ser Glu 
    610                 615                 620                 


Glu Glu Ile Ile Ala Arg Met Met Ile Pro Met Val Asn Glu Val Val 
625                 630                 635                 640 


Arg Cys Leu Glu Glu Gly Ile Ile Ala Thr Pro Ala Glu Ala Asp Met 
                645                 650                 655     


Ala Leu Val Tyr Gly Leu Gly Phe Pro Pro Phe His Gly Gly Ala Phe 
            660                 665                 670         


Arg Trp Leu Asp Thr Leu Gly Ser Ala Lys Tyr Leu Asp Met Ala Gln 
        675                 680                 685             


Gln Tyr Gln His Leu Gly Pro Leu Tyr Glu Val Pro Glu Gly Leu Arg 
    690                 695                 700                 


Asn Lys Ala Arg His Asn Glu Pro Tyr Tyr Pro Pro Val Glu Pro Ala 
705                 710                 715                 720 


Arg Pro Val Gly Asp Leu Lys Thr Ala 
                725                 


<210>  37
<211>  458
<212>  PRT
<213>  Hahella chejuensis

<400>  37

Met Thr Pro Leu Ser Pro Val Asp Gln Ile Phe Leu Trp Leu Glu Lys 
1               5                   10                  15      


Arg Gln Gln Pro Met His Val Gly Gly Leu His Ile Phe Ser Phe Pro 
            20                  25                  30          


Asp Asp Ala Asp Ala Lys Tyr Met Thr Glu Leu Ala Gln Gln Leu Arg 
        35                  40                  45              


Ala Tyr Ala Thr Pro Gln Ala Pro Phe Asn Arg Arg Leu Arg Gln Arg 
    50                  55                  60                  


Trp Gly Arg Tyr Tyr Trp Asp Thr Asp Ala Gln Phe Asp Leu Glu His 
65                  70                  75                  80  


His Phe Arg His Glu Ala Leu Pro Lys Pro Gly Arg Ile Arg Glu Leu 
                85                  90                  95      


Leu Ala His Val Ser Ala Glu His Ser Asn Leu Met Asp Arg Glu Arg 
            100                 105                 110         


Pro Met Trp Glu Cys His Leu Ile Glu Gly Ile Arg Gly Arg Arg Phe 
        115                 120                 125             


Ala Val Tyr Tyr Lys Ala His His Cys Met Leu Asp Gly Val Ala Ala 
    130                 135                 140                 


Met Arg Met Cys Val Lys Ser Tyr Ser Phe Asp Pro Thr Ala Thr Glu 
145                 150                 155                 160 


Met Pro Pro Ile Trp Ala Ile Ser Lys Asp Val Thr Pro Ala Arg Glu 
                165                 170                 175     


Thr Gln Ala Pro Ala Ala Gly Asp Leu Val His Ser Leu Ser Gln Leu 
            180                 185                 190         


Val Glu Gly Ala Gly Arg Gln Leu Ala Thr Val Pro Thr Leu Ile Arg 
        195                 200                 205             


Glu Leu Gly Lys Asn Leu Leu Lys Ala Arg Asp Asp Ser Asp Ala Gly 
    210                 215                 220                 


Leu Ile Phe Arg Ala Pro Pro Ser Ile Leu Asn Gln Arg Ile Thr Gly 
225                 230                 235                 240 


Ser Arg Arg Phe Ala Ala Gln Ser Tyr Ala Leu Glu Arg Phe Lys Ala 
                245                 250                 255     


Ile Gly Lys Ala Phe Gln Ala Thr Val Asn Asp Val Val Leu Ala Val 
            260                 265                 270         


Cys Gly Ser Ala Leu Arg Asn Tyr Leu Leu Ser Arg Gln Ala Leu Pro 
        275                 280                 285             


Asp Gln Pro Leu Ile Ala Met Ala Pro Met Ser Ile Arg Gln Asp Asp 
    290                 295                 300                 


Ser Asp Ser Gly Asn Gln Ile Ala Met Ile Leu Ala Asn Leu Gly Thr 
305                 310                 315                 320 


His Ile Ala Asp Pro Val Arg Arg Leu Glu Leu Thr Gln Ala Ser Ala 
                325                 330                 335     


Arg Glu Ser Lys Glu Arg Phe Arg Gln Met Thr Pro Glu Glu Ala Val 
            340                 345                 350         


Asn Tyr Thr Ala Leu Thr Leu Ala Pro Ser Gly Leu Asn Leu Leu Thr 
        355                 360                 365             


Gly Leu Ala Pro Lys Trp Gln Ala Phe Asn Val Val Ile Ser Asn Val 
    370                 375                 380                 


Pro Gly Pro Asn Lys Pro Leu Tyr Trp Asn Gly Ala Arg Leu Glu Gly 
385                 390                 395                 400 


Met Tyr Pro Val Ser Ile Pro Val Asp Tyr Ala Ala Leu Asn Ile Thr 
                405                 410                 415     


Leu Val Ser Tyr Arg Asp Gln Leu Glu Phe Gly Phe Thr Ala Cys Arg 
            420                 425                 430         


Arg Thr Leu Pro Ser Met Gln Arg Leu Leu Asp Tyr Ile Glu Gln Gly 
        435                 440                 445             


Ile Ala Glu Leu Glu Lys Ala Ala Gly Val 
    450                 455             


<210>  38
<211>  215
<212>  DNA
<213>  Escherichia coli

<400>  38
gatcttgata tcaaacgaac gttttagcag gactgtcgtc ggttgccaac catctgcgag       60

caaagcatgg cgttttgttg cgcgggatca gcaagcctag cggcagttgt ttacgctttt      120

attacagatt taataaatta ccacatttta agaatattat taatctgtaa tatatcttta      180

acaatctcag gttaaaaact ttcctgtttt caacg                                 215


<210>  39
<211>  121
<212>  DNA
<213>  Escherichia coli

<400>  39
aaatcagact gaagacttta tctctctgtc ataaaactgt catattcctt acatataact       60

gtcacctgtt tgtcctattt tgcttctcgt agccaacaaa caatgcttta tgaatcctcc      120

c                                                                      121


