                         SEQUENCE LISTING

<110>  MEDICAGO INC.
 
<120>  INFLUENZA VIRUS HEMAGGLUTININ MUTANTS

<130>  V811304WO2

<150>  US  62/690,780
<151>  2018-06-27

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 HK DNA

<400>  1
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

catcatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg tgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tggaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  2
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 HK AA

<400>  2

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  3
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Minn DNA

<400>  3
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagttggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagagaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catatccagc attgaacgtg actatgccaa acaaggaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg gttgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagagtt caagaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tgaaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattagatgc aacatttgca tttga                     1725


<210>  4
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Minn AA

<400>  4

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Lys Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Glu Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  5
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 SAus DNA

<400>  5
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagttggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagagaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaaaaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catatccagc attgaacgtg actatgccaa acaaggaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg gttgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagagtt caagaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tgaaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattagatgc aacatttgca tttga                     1725


<210>  6
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 SAus AA

<400>  6

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Lys Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Lys Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Glu Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  7
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Bang DNA

<400>  7
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggaaatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catacccagc attgaacgtg actgtgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

cgatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa tcaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tggaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  8
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Bang AA

<400>  8

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Lys Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Val 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Arg Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  9
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz DNA

<400>  9
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  10
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz AA

<400>  10

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  11
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Miss DNA

<400>  11
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcagagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

aaaccatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaaacac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  12
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Miss AA

<400>  12

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Arg Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Lys Pro Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  13
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn DNA

<400>  13
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggaaaaaa ctgcactcta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagag atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacgatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

tcaaacttca aatacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acagacaagg accaaatctt cctgtacgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aaggaatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacaaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg aaggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcttta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  14
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn AA

<400>  14

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Arg Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asp Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Ser Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Gln Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Lys Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  15
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-CPMV(fl5'UTR)_SpPDI.c

<400>  15
tcgtgcttcg gcaccagtac aatggcgaaa aacgttgcga ttttcggct                   49


<210>  16
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-H1cTMCT.S1-4r

<400>  16
actaaagaaa ataggccttt aaatacatat tctacactgt agagac                      46


<210>  17
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-H3A-Ala.r

<400>  17
actaaagaaa ataggccttc aaatgcaaat gttgcaccta atgttgccct tttgg            55


<210>  18
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi_SLVLL.r

<400>  18
agcaactaac agtacaaggg atgatatggc aaaggaaatc cataggatcc a                51


<210>  19
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3_Swi_SLVLL.c

<400>  19
tcctttgcca tatcatccct tgtactgtta gttgctttgt tggggttcat cat              53


<210>  20
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 HK-CysTm DNA

<400>  20
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

catcatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg tgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tggaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  21
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 HK-CysTm AA

<400>  21

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  22
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_HK480114(N382A+L384V).r

<400>  22
ttggttttcc cgatcactcg agccagcttc ccattgattt gatcgatt                    48


<210>  23
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_HK480114(N382A+L384V).c

<400>  23
gggaagctgg ctcgagtgat cgggaaaacc aacgagaaat tccatcag                    48


<210>  24
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 HK-N382A+L384V-CysTm DNA

<400>  24
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

catcatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg tgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg agtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tggaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  25
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 HK-N382A+L384V-CysTm AA

<400>  25

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  26
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Minn-CysTm DNA

<400>  26
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagttggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagagaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catatccagc attgaacgtg actatgccaa acaaggaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg gttgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagagtt caagaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tgaaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattagatgc aacatttgca tttga                     1725


<210>  27
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Minn-CysTm AA

<400>  27

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Lys Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Glu Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  28
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3Minn(N382A+L384V).r

<400>  28
gttggttttc ccgatcaccc gagccagctt cccattgatt tgatcgattg ctgcttgagt       60


<210>  29
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3Minn(N382A+L384V).c

<400>  29
aatcaatggg aagctggctc gggtgatcgg gaaaaccaac gagaaattcc atcaga           56


<210>  30
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Minn-N382A+L384V-CysTm DNA

<400>  30
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagttggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagagaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catatccagc attgaacgtg actatgccaa acaaggaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg ggtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagagtt caagaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tgaaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattagatgc aacatttgca tttga                     1725


<210>  31
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Minn-N382A+L384V-CysTm AA

<400>  31

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Lys Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Glu Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  32
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 SAus-CysTm DNA

<400>  32
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagttggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagagaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaaaaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catatccagc attgaacgtg actatgccaa acaaggaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg gttgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagagtt caagaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tgaaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattagatgc aacatttgca tttga                     1725


<210>  33
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 SAus-CysTm AA

<400>  33

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Lys Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Lys Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Glu Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  34
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 SAus-N382A+L384V-CysTm DNA

<400>  34
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagttggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagagaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaaaaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catatccagc attgaacgtg actatgccaa acaaggaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg ggtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagagtt caagaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tgaaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattagatgc aacatttgca tttga                     1725


<210>  35
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 SAus-N382A+L384V-CysTm AA

<400>  35

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Lys Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Lys Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Glu Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  36
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Bang-CysTm DNA

<400>  36
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggaaatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catacccagc attgaacgtg actgtgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

cgatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa tcaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tggaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  37
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Bang-CysTm AA

<400>  37

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Lys Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Val 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Arg Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  38
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Bang-N382A+L384V-CysTm DNA

<400>  38
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaaat tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca caaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggaaatc tagtagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactaca catacccagc attgaacgtg actgtgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

cgatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccaaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcatagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg agtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga aggaagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa tcaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg aaatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caataagaaa tggaacttat gaccacaatg tgtacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  39
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Bang-N382A+L384V-CysTm AA

<400>  39

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Ile Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Lys Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Val 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Arg Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  40
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(F392D).r

<400>  40
ttttcaatct gatggtcttt ctcgttggtt ttcccgatca atcgattcag cttc             54


<210>  41
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(F392D).c

<400>  41
tcgggaaaac caacgagaaa gaccatcaga ttgaaaaaga attctcag                    48


<210>  42
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-F392D DNA

<400>  42
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaagacca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  43
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-F392D AA

<400>  43

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Asp 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  44
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(L431M).r

<400>  44
ttgtatgttg gttctccatg gcaacaagaa gctccgcgtt gtatgaccag                  50


<210>  45
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(L431M).c

<400>  45
ggagcttctt gttgccatgg agaaccaaca tacaattgat ctaactgact caga             54


<210>  46
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L431M DNA

<400>  46
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccatggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  47
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L431M AA

<400>  47

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  48
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-CysTm DNA

<400>  48
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  49
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-CysTm AA

<400>  49

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  50
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(N382A).r

<400>  50
tttcccgatc aatcgagcca gcttcccatt gatttgatcg attgctgc                    48


<210>  51
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(N382A).c

<400>  51
tcaaatcaat gggaagctgg ctcgattgat cgggaaaacc aacgagaaat tcca             54


<210>  52
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-N382A-CysTm DNA

<400>  52
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  53
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-N382A-CysTm AA

<400>  53

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  54
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(L384V).r

<400>  54
ttggttttcc cgatcactcg attcagcttc ccattgattt gatcgatt                    48


<210>  55
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H3_Swi(L384V).c

<400>  55
gggaagctga atcgagtgat cgggaaaacc aacgagaaat tccatcag                    48


<210>  56
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L384V-CysTm DNA

<400>  56
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg agtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  57
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L384V-CysTm AA

<400>  57

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  58
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-F392D-CysTm DNA

<400>  58
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaagacca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  59
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-F392D-CysTm AA

<400>  59

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Asp 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  60
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L431M-CysTm DNA

<400>  60
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccatggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  61
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L431M-CysTm AA

<400>  61

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  62
<211>  4540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning vector 1190 from left to right T-DNA

<400>  62
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa     2940

ccaaaccttc ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc     3000

ttgcgtgagc gatcttcaac gttgtcagat cgtgcttcgg caccgcggat ggcgaaaaac     3060

gttgcgattt tcggcttatt gttttctctt cttgtgttgg ttccttctca gatcttcgcc     3120

tgcaggctcc tcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc     3180

tgcccaaact aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc     3240

agtgacagtg acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt     3300

cctgcagtct gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc     3360

cagcgagacc gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa     3420

aattgtgccc agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc     3480

tgtcttcatc ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt     3540

cacgtgtgtt gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt     3600

agatgatgtg gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac     3660

tttccgctca gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagcg     3720

atcgctcacc atcaccatca ccatcaccat caccattaaa ggcctatttt ctttagtttg     3780

aatttactgt tattcggtgt gcatttctat gtttggtgag cggttttctg tgctcagagt     3840

gtgtttattt tatgtaattt aatttctttg tgagctcctg tttagcaggt cgtcccttca     3900

gcaaggacac aaaaagattt taattttatt aaaaaaaaaa aaaaaaaaga ccgggaattc     3960

gatatcaagc ttatcgacct gcagatcgtt caaacatttg gcaataaagt ttcttaagat     4020

tgaatcctgt tgccggtctt gcgatgatta tcatataatt tctgttgaat tacgttaagc     4080

atgtaataat taacatgtaa tgcatgacgt tatttatgag atgggttttt atgattagag     4140

tcccgcaatt atacatttaa tacgcgatag aaaacaaaat atagcgcgca aactaggata     4200

aattatcgcg cgcggtgtca tctatgttac tagatctcta gagtctcaag cttggcgcgc     4260

ccacgtgact agtggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     4320

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     4380

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgctagagca     4440

gcttgagctt ggatcagatt gtcgtttccc gccttcagtt taaactatca gtgtttgaca     4500

ggatatattg gcgggtaaac ctaagagaaa agagcgttta                           4540


<210>  63
<211>  3105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 1314 from 2X35S prom to NOS term

<400>  63
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gcgaaaaacg ttgcgatttt cggcttattg ttttctcttc ttgtgttggt      960

tccttctcag atcttcgctg acacattatg tataggttat catgcgaaca attcaacaga     1020

cactgtagac acagtactag aaaagaatgt aacagtaaca cactctgtta accttctaga     1080

agacaagcat aacgggaaac tatgcaaact aagaggggta gccccattgc atttgggtaa     1140

atgtaacatt gctggctgga tcctgggaaa tccagagtgt gaatcactct ccacagcaag     1200

ctcatggtcc tacattgtgg aaacacctag ttcagacaat ggaacgtgtt acccaggaga     1260

tttcatcgat tatgaggagc taagagagca attgagctca gtgtcatcat ttgaaaggtt     1320

tgagatattc cccaagacaa gttcatggcc caatcatgac tcgaacaaag gtgtaacggc     1380

agcatgtcct catgctggag caaaaagctt ctacaaaaat ttaatatggc tagttaaaaa     1440

aggaaattca tacccaaagc tcagcaaatc ctacattaat gataaaggga aagaagtcct     1500

cgtgctatgg ggcattcacc atccatctac tagtgctgac caacaaagtc tctatcagaa     1560

tgcagatgca tatgtttttg tggggtcatc aagatacagc aagaagttca agccggaaat     1620

agcaataaga cccaaagtga gggatcaaga agggagaatg aactattact ggacactagt     1680

agagccggga gacaaaataa cattcgaagc aactggaaat ctagtggtac cgagatatgc     1740

attcgcaatg gaaagaaatg ctggatctgg tattatcatt tcagatacac cagtccacga     1800

ttgcaataca acttgtcaaa cacccaaggg tgctataaac accagcctcc catttcagaa     1860

tatacatccg atcacaattg gaaaatgtcc aaaatatgta aaaagcacaa aattgagact     1920

ggccacagga ttgaggaata tcccgtctat tcaatctaga ggactatttg gggccattgc     1980

cggtttcatt gaaggggggt ggacagggat ggtagatgga tggtacggtt atcaccatca     2040

aaatgagcag gggtcaggat atgcagccga cctgaagagc acacagaatg ccattgacga     2100

gattactaac aaagtaaatt ctgttattga aaagatgaat acacagttca cagcagtagg     2160

taaagagttc aaccacctgg aaaaaagaat agagaattta aataaaaaag ttgatgatgg     2220

tttcctggac atttggactt acaatgccga actgttggtt ctattggaaa atgaaagaac     2280

tttggactac cacgattcaa atgtgaagaa cttatatgaa aaggtaagaa gccagctaaa     2340

aaacaatgcc aaggaaattg gaaacggctg ctttgaattt taccacaaat gcgataacac     2400

gtgcatggaa agtgtcaaaa atgggactta tgactaccca aaatactcag aggaagcaaa     2460

attaaacaga gaagaaatag atggggtaaa gctggaatca acaaggattt accagatttt     2520

ggcgatctat tcaactgtcg ccagttcatt ggtactggta gtctccctgg gggcaatcag     2580

tttctggatg tgctctaatg ggtctctaca gtgtagaata tgtatttaaa ggcctatttt     2640

ctttagtttg aatttactgt tattcggtgt gcatttctat gtttggtgag cggttttctg     2700

tgctcagagt gtgtttattt tatgtaattt aatttctttg tgagctcctg tttagcaggt     2760

cgtcccttca gcaaggacac aaaaagattt taattttatt aaaaaaaaaa aaaaaaaaga     2820

ccgggaattc gatatcaagc ttatcgacct gcagatcgtt caaacatttg gcaataaagt     2880

ttcttaagat tgaatcctgt tgccggtctt gcgatgatta tcatataatt tctgttgaat     2940

tacgttaagc atgtaataat taacatgtaa tgcatgacgt tatttatgag atgggttttt     3000

atgattagag tcccgcaatt atacatttaa tacgcgatag aaaacaaaat atagcgcgca     3060

aactaggata aattatcgcg cgcggtgtca tctatgttac tagat                     3105


<210>  64
<211>  3105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 2980 from 2X35S prom to NOS term

<400>  64
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gcgaaaaacg ttgcgatttt cggcttattg ttttctcttc ttgtgttggt      960

tccttctcag atcttcgcgg acacattatg tataggttat catgcgaaca attcaacaga     1020

cactgtagac acagtactag aaaagaatgt aacagtaaca cactctgtta accttctaga     1080

agacaagcat aacgggaaac tatgcaaact aagaggggta gccccattgc atttgggtaa     1140

atgtaacatt gctggctgga tcctgggaaa tccagagtgt gaatcactct ccacagcaag     1200

ctcatggtcc tacattgtgg aaacacctag ttcagacaat ggaacgtgtt acccaggaga     1260

tttcatcgat tatgaggagc taagagagca attgagctca gtgtcatcat ttgaaaggtt     1320

tgagatattc cccaagacaa gttcatggcc caatcatgac tcgaacaaag gtgtaacggc     1380

agcatgtcct catgctggag caaaaagctt ctacaaaaat ttaatatggc tagttaaaaa     1440

aggaaattca tacccaaagc tcagcaaatc ctacattaat gataaaggga aagaagtcct     1500

cgtgctatgg ggcattcacc atccatctac tagtgctgac caacaaagtc tctatcagaa     1560

tgcagatgca tatgtttttg tggggtcatc aagatacagc aagaagttca agccggaaat     1620

agcaataaga cccaaagtga gggatcaaga agggagaatg aactattact ggacactagt     1680

agagccggga gacaaaataa cattcgaagc aactggaaat ctagtggtac cgagatatgc     1740

attcgcaatg gaaagaaatg ctggatctgg tattatcatt tcagatacac cagtccacga     1800

ttgcaataca acttgtcaaa cacccaaggg tgctataaac accagcctcc catttcagaa     1860

tatacatccg atcacaattg gaaaatgtcc aaaatatgta aaaagcacaa aattgagact     1920

ggccacagga ttgaggaata tcccgtctat tcaatctaga ggactatttg gggccattgc     1980

cggtttcatt gaaggggggt ggacagggat ggtagatgga tggtacggtt atcaccatca     2040

aaatgagcag gggtcaggat atgcagccga cctgaagagc acacagaatg ccattgacga     2100

gattactaac aaagtaaatt ctgttattga aaagatgaat acacaggaca cagcagtagg     2160

taaagagttc aaccacctgg aaaaaagaat agagaattta aataaaaaag ttgatgatgg     2220

tttcctggac atttggactt acaatgccga actgttggtt ctattggaaa atgaaagaac     2280

tttggactac cacgattcaa atgtgaagaa cttatatgaa aaggtaagaa gccagctaaa     2340

aaacaatgcc aaggaaattg gaaacggctg ctttgaattt taccacaaat gcgataacac     2400

gtgcatggaa agtgtcaaaa atgggactta tgactaccca aaatactcag aggaagcaaa     2460

attaaacaga gaagaaatag atggggtaaa gctggaatca acaaggattt accagatttt     2520

ggcgatctat tcaactgtcg ccagttcatt ggtactggta gtctccctgg gggcaatcag     2580

tttctggatg tgctctaatg ggtctctaca gtgtagaata tgtatttaaa ggcctatttt     2640

ctttagtttg aatttactgt tattcggtgt gcatttctat gtttggtgag cggttttctg     2700

tgctcagagt gtgtttattt tatgtaattt aatttctttg tgagctcctg tttagcaggt     2760

cgtcccttca gcaaggacac aaaaagattt taattttatt aaaaaaaaaa aaaaaaaaga     2820

ccgggaattc gatatcaagc ttatcgacct gcagatcgtt caaacatttg gcaataaagt     2880

ttcttaagat tgaatcctgt tgccggtctt gcgatgatta tcatataatt tctgttgaat     2940

tacgttaagc atgtaataat taacatgtaa tgcatgacgt tatttatgag atgggttttt     3000

atgattagag tcccgcaatt atacatttaa tacgcgatag aaaacaaaat atagcgcgca     3060

aactaggata aattatcgcg cgcggtgtca tctatgttac tagat                     3105


<210>  65
<211>  3105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 2995 from 2X35S prom to NOS term

<400>  65
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gcgaaaaacg ttgcgatttt cggcttattg ttttctcttc ttgtgttggt      960

tccttctcag atcttcgcgg acacattatg tataggttat catgcgaaca attcaacaga     1020

cactgtagac acagtactag aaaagaatgt aacagtaaca cactctgtta accttctaga     1080

agacaagcat aacgggaaac tatgcaaact aagaggggta gccccattgc atttgggtaa     1140

atgtaacatt gctggctgga tcctgggaaa tccagagtgt gaatcactct ccacagcaag     1200

ctcatggtcc tacattgtgg aaacacctag ttcagacaat ggaacgtgtt acccaggaga     1260

tttcatcgat tatgaggagc taagagagca attgagctca gtgtcatcat ttgaaaggtt     1320

tgagatattc cccaagacaa gttcatggcc caatcatgac tcgaacaaag gtgtaacggc     1380

agcatgtcct catgctggag caaaaagctt ctacaaaaat ttaatatggc tagttaaaaa     1440

aggaaattca tacccaaagc tcagcaaatc ctacattaat gataaaggga aagaagtcct     1500

cgtgctatgg ggcattcacc atccatctac tagtgctgac caacaaagtc tctatcagaa     1560

tgcagatgca tatgtttttg tggggtcatc aagatacagc aagaagttca agccggaaat     1620

agcaataaga cccaaagtga gggatcaaga agggagaatg aactattact ggacactagt     1680

agagccggga gacaaaataa cattcgaagc aactggaaat ctagtggtac cgagatatgc     1740

attcgcaatg gaaagaaatg ctggatctgg tattatcatt tcagatacac cagtccacga     1800

ttgcaataca acttgtcaaa cacccaaggg tgctataaac accagcctcc catttcagaa     1860

tatacatccg atcacaattg gaaaatgtcc aaaatatgta aaaagcacaa aattgagact     1920

ggccacagga ttgaggaata tcccgtctat tcaatctaga ggactatttg gggccattgc     1980

cggtttcatt gaaggggggt ggacagggat ggtagatgga tggtacggtt atcaccatca     2040

aaatgagcag gggtcaggat atgcagccga cctgaagagc acacagaatg ccattgacga     2100

gattactaac aaagtaaatt ctgttattga aaagatgaat acacaggaca cagcagtagg     2160

taaagagttc aaccacctgg aaaaaagaat agagaattta aataaaaaag ttgatgatgg     2220

tttcctggac atttggactt acaatgccga actgttggtt ctaatggaaa atgaaagaac     2280

tttggactac cacgattcaa atgtgaagaa cttatatgaa aaggtaagaa gccagctaaa     2340

aaacaatgcc aaggaaattg gaaacggctg ctttgaattt taccacaaat gcgataacac     2400

gtgcatggaa agtgtcaaaa atgggactta tgactaccca aaatactcag aggaagcaaa     2460

attaaacaga gaagaaatag atggggtaaa gctggaatca acaaggattt accagatttt     2520

ggcgatctat tcaactgtcg ccagttcatt ggtactggta gtctccctgg gggcaatcag     2580

tttctggatg tgctctaatg ggtctctaca gtgtagaata tgtatttaaa ggcctatttt     2640

ctttagtttg aatttactgt tattcggtgt gcatttctat gtttggtgag cggttttctg     2700

tgctcagagt gtgtttattt tatgtaattt aatttctttg tgagctcctg tttagcaggt     2760

cgtcccttca gcaaggacac aaaaagattt taattttatt aaaaaaaaaa aaaaaaaaga     2820

ccgggaattc gatatcaagc ttatcgacct gcagatcgtt caaacatttg gcaataaagt     2880

ttcttaagat tgaatcctgt tgccggtctt gcgatgatta tcatataatt tctgttgaat     2940

tacgttaagc atgtaataat taacatgtaa tgcatgacgt tatttatgag atgggttttt     3000

atgattagag tcccgcaatt atacatttaa tacgcgatag aaaacaaaat atagcgcgca     3060

aactaggata aattatcgcg cgcggtgtca tctatgttac tagat                     3105


<210>  66
<211>  6360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning vector 3556 from left to right T-DNA

<400>  66
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca cgcgtggcgc gccctggtat atttatatgt     2160

tgtcaaataa ctcaaaaacc ataaaagttt aagttagcaa gtgtgtacat ttttacttga     2220

acaaaaatat tcacctacta ctgttataaa tcattattaa acattagagt aaagaaatat     2280

ggatgataag aacaagagta gtgatatttt gacaacaatt ttgttgcaac atttgagaaa     2340

attttgttgt tctctctttt cattggtcaa aaacaataga gagagaaaaa ggaagaggga     2400

gaataaaaac ataatgtgag tatgagagag aaagttgtac aaaagttgta ccaaaatagt     2460

tgtacaaata tcattgagga atttgacaaa agctacacaa ataagggtta attgctgtaa     2520

ataaataagg atgacgcatt agagagatgt accattagag aatttttggc aagtcattaa     2580

aaagaaagaa taaattattt ttaaaattaa aagttgagtc atttgattaa acatgtgatt     2640

atttaatgaa ttgatgaaag agttggatta aagttgtatt agtaattaga atttggtgtc     2700

aaatttaatt tgacatttga tcttttccta tatattgccc catagagtca gttaactcat     2760

ttttatattt catagatcaa ataagagaaa taacggtata ttaatccctc caaaaaaaaa     2820

aaacggtata tttactaaaa aatctaagcc acgtaggagg ataacaggat ccccgtagga     2880

ggataacatc caatccaacc aatcacaaca atcctgatga gataacccac tttaagccca     2940

cgcatctgtg gcacatctac attatctaaa tcacacattc ttccacacat ctgagccaca     3000

caaaaaccaa tccacatctt tatcacccat tctataaaaa atcacacttt gtgagtctac     3060

actttgattc ccttcaaaca catacaaaga gaagagacta attaattaat taatcatctt     3120

gagagaaaat gagtcttcta accgaggtcg aaacgcctat cagaaacgaa tgggggtgca     3180

gatgcaacga ttcaagtgat cctcttgttg ttgccgcaag tataattggg attgtgcacc     3240

tgatattgtg gattattgat cgcctttttt ccaaaagcat ttatcgtatc tttaaacacg     3300

gtttaaaaag agggccttct acggaaggag taccagagtc tatgagggaa gaatatcgag     3360

aggaacagca gaatgctgtg gatgctgacg atggtcattt tgtcagcata gagctggagt     3420

aagagctcta agttaaaatg cttcttcgtc tcctatttat aatatggttt gttattgtta     3480

attttgttct tgtagaagag cttaattaat cgttgttgtt atgaaatact atttgtatga     3540

gatgaactgg tgtaatgtaa ttcatttaca taagtggagt cagaatcaga atgtttcctc     3600

cataactaac tagacatgaa gacctgccgc gtacaattgt cttatatttg aacaactaaa     3660

attgaacatc ttttgccaca actttataag tggttaatat agctcaaata tatggtcaag     3720

ttcaatagat taataatgga aatatcagtt atcgaaattc attaacaatc aacttaacgt     3780

tattaactac taattttata tcatcccctt tgataaatga tagtacacca attaggaagg     3840

aactaggaga ttgtcgtttc ccgccttcag tttgcaagct gctctagccg tgtagccaat     3900

acgcaaaccg cctctccccg cgcgttggga attactagcg cgtgtcgaca agcttgcatg     3960

ccggtcaaca tggtggagca cgacacactt gtctactcca aaaatatcaa agatacagtc     4020

tcagaagacc aaagggcaat tgagactttt caacaaaggg taatatccgg aaacctcctc     4080

ggattccatt gcccagctat ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc     4140

tcctacaaat gccatcattg cgataaagga aaggccatcg ttgaagatgc ctctgccgac     4200

agtggtccca aagatggacc cccacccacg aggagcatcg tggaaaaaga agacgttcca     4260

accacgtctt caaagcaagt ggattgatgt gataacatgg tggagcacga cacacttgtc     4320

tactccaaaa atatcaaaga tacagtctca gaagaccaaa gggcaattga gacttttcaa     4380

caaagggtaa tatccggaaa cctcctcgga ttccattgcc cagctatctg tcactttatt     4440

gtgaagatag tggaaaagga aggtggctcc tacaaatgcc atcattgcga taaaggaaag     4500

gccatcgttg aagatgcctc tgccgacagt ggtcccaaag atggaccccc acccacgagg     4560

agcatcgtgg aaaaagaaga cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat     4620

atctccactg acgtaaggga tgacgcacaa tcccactatc cttcgcaaga cccttcctct     4680

atataaggaa gttcatttca tttggagagg tattaaaatc ttaataggtt ttgataaaag     4740

cgaacgtggg gaaacccgaa ccaaaccttc ttctaaactc tctctcatct ctcttaaagc     4800

aaacttctct cttgtctttc ttgcgtgagc gatcttcaac gttgtcagat cgtgcttcgg     4860

caccgcggat ggcgaaaaac gttgcgattt tcggcttatt gttttctctt cttgtgttgg     4920

ttccttctca gatcttcgcc tgcaggctcc tcagccaaaa cgacaccccc atctgtctat     4980

ccactggccc ctggatctgc tgcccaaact aactccatgg tgaccctggg atgcctggtc     5040

aagggctatt tccctgagcc agtgacagtg acctggaact ctggatccct gtccagcggt     5100

gtgcacacct tcccagctgt cctgcagtct gacctctaca ctctgagcag ctcagtgact     5160

gtcccctcca gcacctggcc cagcgagacc gtcacctgca acgttgccca cccggccagc     5220

agcaccaagg tggacaagaa aattgtgccc agggattgtg gttgtaagcc ttgcatatgt     5280

acagtcccag aagtatcatc tgtcttcatc ttccccccaa agcccaagga tgtgctcacc     5340

attactctga ctcctaaggt cacgtgtgtt gtggtagaca tcagcaagga tgatcccgag     5400

gtccagttca gctggtttgt agatgatgtg gaggtgcaca cagctcagac gcaaccccgg     5460

gaggagcagt tcaacagcac tttccgctca gtcagtgaac ttcccatcat gcaccaggac     5520

tggctcaatg gcaaggagcg atcgctcacc atcaccatca ccatcaccat caccattaaa     5580

ggcctatttt ctttagtttg aatttactgt tattcggtgt gcatttctat gtttggtgag     5640

cggttttctg tgctcagagt gtgtttattt tatgtaattt aatttctttg tgagctcctg     5700

tttagcaggt cgtcccttca gcaaggacac aaaaagattt taattttatt aaaaaaaaaa     5760

aaaaaaaaga ccgggaattc gatatcaagc ttatcgacct gcagatcgtt caaacatttg     5820

gcaataaagt ttcttaagat tgaatcctgt tgccggtctt gcgatgatta tcatataatt     5880

tctgttgaat tacgttaagc atgtaataat taacatgtaa tgcatgacgt tatttatgag     5940

atgggttttt atgattagag tcccgcaatt atacatttaa tacgcgatag aaaacaaaat     6000

atagcgcgca aactaggata aattatcgcg cgcggtgtca tctatgttac tagatctcta     6060

gagtctcaag cttggcgcgc ccacgtgact agtggcactg gccgtcgttt tacaacgtcg     6120

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     6180

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     6240

gaatggcgaa tgctagagca gcttgagctt ggatcagatt gtcgtttccc gccttcagtt     6300

taaactatca gtgtttgaca ggatatattg gcgggtaaac ctaagagaaa agagcgttta     6360


<210>  67
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-H5ITMCT.s1-4r

<400>  67
actaaagaaa ataggccttt aaatgcaaat tctgcattgt aacgatccat                  50


<210>  68
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Indo DNA

<400>  68
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ccgatcagat ttgcattggt taccatgcaa acaattcaac agagcaggtt      120

gacacaatca tggaaaagaa cgttactgtt acacatgccc aagacatact ggaaaagaca      180

cacaacggga agctctgcga tctagatgga gtgaagcctc taattttaag agattgtagt      240

gtagctggat ggctcctcgg gaacccaatg tgtgacgaat tcatcaatgt accggaatgg      300

tcttacatag tggagaaggc caatccaacc aatgacctct gttacccagg gagtttcaac      360

gactatgaag aactgaaaca cctattgagc agaataaacc attttgagaa aattcaaatc      420

atccccaaaa gttcttggtc cgatcatgaa gcctcatcag gagttagctc agcatgtcca      480

tacctgggaa gtccctcctt ttttagaaat gtggtatggc ttatcaaaaa gaacagtaca      540

tacccaacaa taaagaaaag ctacaataat accaaccaag aggatctttt ggtactgtgg      600

ggaattcacc atcctaatga tgcggcagag cagacaaggc tatatcaaaa cccaaccacc      660

tatatttcca ttgggacatc aacactaaac cagagattgg taccaaaaat agctactaga      720

tccaaagtaa acgggcaaag tggaaggatg gagttcttct ggacaatttt aaaacctaat      780

gatgcaatca acttcgagag taatggaaat ttcattgctc cagaatatgc atacaaaatt      840

gtcaagaaag gggactcagc aattatgaaa agtgaattgg aatatggtaa ctgcaacacc      900

aagtgtcaaa ctccaatggg ggcgataaac tctagtatgc cattccacaa catacaccct      960

ctcaccatcg gggaatgccc caaatatgtg aaatcaaaca gattagtcct tgcaacaggg     1020

ctcagaaata gccctcaaag agagagcaga agaaaaaaga gaggactatt tggagctata     1080

gcaggtttta tagagggagg atggcaggga atggtagatg gttggtatgg gtaccaccat     1140

agcaatgagc aggggagtgg gtacgctgca gacaaagaat ccactcaaaa ggcaatagat     1200

ggagtcacca ataaggtcaa ctcaatcatt gacaaaatga acactcagtt tgaggccgtt     1260

ggaagggaat ttaataactt agaaaggaga atagagaatt taaacaagaa gatggaagac     1320

gggtttctag atgtctggac ttataatgcc gaacttctgg ttctcatgga aaatgagaga     1380

actctagact ttcatgactc aaatgttaag aacctctacg acaaggtccg actacagctt     1440

agggataatg caaaggagct gggtaacggt tgtttcgagt tctatcacaa atgtgataat     1500

gaatgtatgg aaagtataag aaacggaacg tacaactatc cgcagtattc agaagaagca     1560

agattaaaaa gagaggaaat aagtggggta aaattggaat caataggaac ttaccaaata     1620

ctgtcaattt attcaacagt ggcgagttcc ctagcactgg caatcatgat ggctggtcta     1680

tctttatgga tgtgctccaa tggatcgtta caatgcagaa tttgcattta a              1731


<210>  69
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Indo AA

<400>  69

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile Leu Arg Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Ile Asn 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala Asn Pro Thr Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Ser Phe Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile Ile Pro Lys Ser 
    130                 135                 140                 


Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val Ser Ser Ala Cys Pro 
145                 150                 155                 160 


Tyr Leu Gly Ser Pro Ser Phe Phe Arg Asn Val Val Trp Leu Ile Lys 
                165                 170                 175     


Lys Asn Ser Thr Tyr Pro Thr Ile Lys Lys Ser Tyr Asn Asn Thr Asn 
            180                 185                 190         


Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His His Pro Asn Asp Ala 
        195                 200                 205             


Ala Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr Thr Tyr Ile Ser Ile 
    210                 215                 220                 


Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg 
225                 230                 235                 240 


Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe Phe Trp Thr Ile 
                245                 250                 255     


Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser Asn Gly Asn Phe Ile 
            260                 265                 270         


Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Ala Ile 
        275                 280                 285             


Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn Thr Lys Cys Gln Thr 
    290                 295                 300                 


Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro 
305                 310                 315                 320 


Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg Leu Val 
                325                 330                 335     


Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg Glu Ser Arg Arg Lys 
            340                 345                 350         


Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
        355                 360                 365             


Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln 
    370                 375                 380                 


Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp 
385                 390                 395                 400 


Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln 
                405                 410                 415     


Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu 
            420                 425                 430         


Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr 
        435                 440                 445             


Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe 
    450                 455                 460                 


His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu 
465                 470                 475                 480 


Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His 
                485                 490                 495     


Lys Cys Asp Asn Glu Cys Met Glu Ser Ile Arg Asn Gly Thr Tyr Asn 
            500                 505                 510         


Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser 
        515                 520                 525             


Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr 
    530                 535                 540                 


Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Met Ala Gly Leu 
545                 550                 555                 560 


Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575     


<210>  70
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H5Ind(F393D).r

<400>  70
cttccaacgg cctcgtcctg agtgttcatt ttgtcaatga ttgagttga                   49


<210>  71
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H5Ind(F393D).c

<400>  71
caaaatgaac actcaggacg aggccgttgg aagggaattt aataactta                   49


<210>  72
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Indo-F393D DNA

<400>  72
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggatcagat ttgcattggt taccatgcaa acaattcaac agagcaggtt      120

gacacaatca tggaaaagaa cgttactgtt acacatgccc aagacatact ggaaaagaca      180

cacaacggga agctctgcga tctagatgga gtgaagcctc taattttaag agattgtagt      240

gtagctggat ggctcctcgg gaacccaatg tgtgacgaat tcatcaatgt accggaatgg      300

tcttacatag tggagaaggc caatccaacc aatgacctct gttacccagg gagtttcaac      360

gactatgaag aactgaaaca cctattgagc agaataaacc attttgagaa aattcaaatc      420

atccccaaaa gttcttggtc cgatcatgaa gcctcatcag gagttagctc agcatgtcca      480

tacctgggaa gtccctcctt ttttagaaat gtggtatggc ttatcaaaaa gaacagtaca      540

tacccaacaa taaagaaaag ctacaataat accaaccaag aggatctttt ggtactgtgg      600

ggaattcacc atcctaatga tgcggcagag cagacaaggc tatatcaaaa cccaaccacc      660

tatatttcca ttgggacatc aacactaaac cagagattgg taccaaaaat agctactaga      720

tccaaagtaa acgggcaaag tggaaggatg gagttcttct ggacaatttt aaaacctaat      780

gatgcaatca acttcgagag taatggaaat ttcattgctc cagaatatgc atacaaaatt      840

gtcaagaaag gggactcagc aattatgaaa agtgaattgg aatatggtaa ctgcaacacc      900

aagtgtcaaa ctccaatggg ggcgataaac tctagtatgc cattccacaa catacaccct      960

ctcaccatcg gggaatgccc caaatatgtg aaatcaaaca gattagtcct tgcaacaggg     1020

ctcagaaata gccctcaaag agagagcaga agaaaaaaga gaggactatt tggagctata     1080

gcaggtttta tagagggagg atggcaggga atggtagatg gttggtatgg gtaccaccat     1140

agcaatgagc aggggagtgg gtacgctgca gacaaagaat ccactcaaaa ggcaatagat     1200

ggagtcacca ataaggtcaa ctcaatcatt gacaaaatga acactcagga cgaggccgtt     1260

ggaagggaat ttaataactt agaaaggaga atagagaatt taaacaagaa gatggaagac     1320

gggtttctag atgtctggac ttataatgcc gaacttctgg ttctcatgga aaatgagaga     1380

actctagact ttcatgactc aaatgttaag aacctctacg acaaggtccg actacagctt     1440

agggataatg caaaggagct gggtaacggt tgtttcgagt tctatcacaa atgtgataat     1500

gaatgtatgg aaagtataag aaacggaacg tacaactatc cgcagtattc agaagaagca     1560

agattaaaaa gagaggaaat aagtggggta aaattggaat caataggaac ttaccaaata     1620

ctgtcaattt attcaacagt ggcgagttcc ctagcactgg caatcatgat ggctggtcta     1680

tctttatgga tgtgctccaa tggatcgtta caatgcagaa tttgcattta a              1731


<210>  73
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Indo-F393D AA

<400>  73

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile Leu Arg Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Ile Asn 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala Asn Pro Thr Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Ser Phe Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile Ile Pro Lys Ser 
    130                 135                 140                 


Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val Ser Ser Ala Cys Pro 
145                 150                 155                 160 


Tyr Leu Gly Ser Pro Ser Phe Phe Arg Asn Val Val Trp Leu Ile Lys 
                165                 170                 175     


Lys Asn Ser Thr Tyr Pro Thr Ile Lys Lys Ser Tyr Asn Asn Thr Asn 
            180                 185                 190         


Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His His Pro Asn Asp Ala 
        195                 200                 205             


Ala Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr Thr Tyr Ile Ser Ile 
    210                 215                 220                 


Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg 
225                 230                 235                 240 


Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe Phe Trp Thr Ile 
                245                 250                 255     


Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser Asn Gly Asn Phe Ile 
            260                 265                 270         


Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Ala Ile 
        275                 280                 285             


Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn Thr Lys Cys Gln Thr 
    290                 295                 300                 


Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro 
305                 310                 315                 320 


Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg Leu Val 
                325                 330                 335     


Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg Glu Ser Arg Arg Lys 
            340                 345                 350         


Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
        355                 360                 365             


Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln 
    370                 375                 380                 


Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp 
385                 390                 395                 400 


Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln 
                405                 410                 415     


Asp Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu 
            420                 425                 430         


Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr 
        435                 440                 445             


Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe 
    450                 455                 460                 


His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu 
465                 470                 475                 480 


Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His 
                485                 490                 495     


Lys Cys Asp Asn Glu Cys Met Glu Ser Ile Arg Asn Gly Thr Tyr Asn 
            500                 505                 510         


Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser 
        515                 520                 525             


Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr 
    530                 535                 540                 


Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Met Ala Gly Leu 
545                 550                 555                 560 


Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575     


<210>  74
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-H5_Egy.r

<400>  74
actaaagaaa ataggccttt aaatgcaaat tctgcattgt agcgatccat t                51


<210>  75
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Egypt DNA

<400>  75
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggatcagat ttgcattggt taccatgcaa acaactcgac agagcaggtt      120

gacacaataa tggaaaagaa tgtcactgtt acacacgccc aagacatact ggaaaagaca      180

cacaacggga aactctgcaa tctagatgga gtgaagcctc tcattttgag agattgtagt      240

gtagctggat ggctcctcgg gaacccaatg tgcgatgaat tcctcaatgt gccggaatgg      300

tcttacatag tggagaaaat caatccagcc aatgacctct gttatccagg gaatttcaac      360

gactatgaag aactgaaaca cctattgagc agaataaacc attttgagaa aattcagatc      420

attcccaaag attcttggtc agatcatgaa gcctcgggag tgagctcagc atgcccatac      480

caaggaagat cctccttttt tagaaatgtt gtatggctta ccaaaaagaa cgatgcatac      540

ccaacaataa agaaaagtta caataatact aaccaagaag atcttttggt actatggggg      600

attcaccatc caaatgatgc tgcagagcag acaaggcttt atcaaaaccc aactacctat      660

atctccgttg ggacatcaac actaaaccag agattggtac ccaaaatagc tactagatct      720

aaggtaaacg ggcaaagtgg aaggatggag ttcttttgga caattttaaa atcgaatgat      780

gcaataaact ttgagagcaa tggaaacttc attgctccag aaaatgcata caaaattgtc      840

aagaaaggag attcaacaat tatgaaaagt gagttggaat atagtaactg caacaccaag      900

tgtcagactc caataggggc gataaactcc agtatgccat tccacaacat ccaccctctc      960

accatcgggg aatgccccaa atatgtgaaa tcaaacagat tagtccttgc tactgggctc     1020

aggaatagcc ctcaaggaga gaaaagaaga aaaaagagag gactattcgg agccatagca     1080

ggctttatag agggaggatg gcagggaatg gtagatggtt ggtatgggta ccaccatagc     1140

aacgagcagg ggagtgggta cgctgcagac aaagaatcca ctcaaagggc tatagatgga     1200

gtcaccaata aggtcaattc gatcattgac aaaatgaaca ctcagtttga ggctgttgga     1260

agggaattta ataacttaga aaggagaata gaaaatttaa acaagaagat ggaagacgga     1320

ttcctagatg tctggactta taatgctgaa cttctggttc tcatggaaaa tgagagaact     1380

ctagactttc atgactcaaa tgtcaagaat ctttatgaca aggtccgact acagcttagg     1440

gataatgcaa aggagcttgg taacggttgt ttcgagttct atcacagatg tgataatgaa     1500

tgtatggaaa gtgtaagaaa cggaacgtat gactaccctc aatattcaga agaagcaaga     1560

ttaaaaagag aggaaataag tggagtaaaa ttggagtcaa taggaactta ccaaatactg     1620

tcaatttatt caacagtggc gagctcccta gcactggcaa tcatggtggc tggtctatct     1680

ttatggatgt gctccaatgg atcgctacaa tgcagaattt gcatttaa                  1728


<210>  76
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Egypt AA

<400>  76

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asn Leu Asp Gly Val Lys Pro Leu Ile Leu Arg Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Leu Asn 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ile Asn Pro Ala Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile Ile Pro Lys Asp 
    130                 135                 140                 


Ser Trp Ser Asp His Glu Ala Ser Gly Val Ser Ser Ala Cys Pro Tyr 
145                 150                 155                 160 


Gln Gly Arg Ser Ser Phe Phe Arg Asn Val Val Trp Leu Thr Lys Lys 
                165                 170                 175     


Asn Asp Ala Tyr Pro Thr Ile Lys Lys Ser Tyr Asn Asn Thr Asn Gln 
            180                 185                 190         


Glu Asp Leu Leu Val Leu Trp Gly Ile His His Pro Asn Asp Ala Ala 
        195                 200                 205             


Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly 
    210                 215                 220                 


Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg Ser 
225                 230                 235                 240 


Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe Phe Trp Thr Ile Leu 
                245                 250                 255     


Lys Ser Asn Asp Ala Ile Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala 
            260                 265                 270         


Pro Glu Asn Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Thr Ile Met 
        275                 280                 285             


Lys Ser Glu Leu Glu Tyr Ser Asn Cys Asn Thr Lys Cys Gln Thr Pro 
    290                 295                 300                 


Ile Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro Leu 
305                 310                 315                 320 


Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg Leu Val Leu 
                325                 330                 335     


Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly Glu Lys Arg Arg Lys Lys 
            340                 345                 350         


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly 
    370                 375                 380                 


Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Arg Ala Ile Asp Gly 
385                 390                 395                 400 


Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe 
                405                 410                 415     


Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn 
            420                 425                 430         


Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His 
    450                 455                 460                 


Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg 
465                 470                 475                 480 


Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Arg 
                485                 490                 495     


Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr 
            500                 505                 510         


Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly 
        515                 520                 525             


Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr Ser 
    530                 535                 540                 


Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser 
545                 550                 555                 560 


Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575 


<210>  77
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H5Egy(F392D).r

<400>  77
cttccaacag cctcgtcctg agtgttcatt ttgtcaatga tcgaattga                   49


<210>  78
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer H5Egy(F392D).c

<400>  78
caaaatgaac actcaggacg aggctgttgg aagggaattt aataactta                   49


<210>  79
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Egypt-F392D DNA

<400>  79
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggatcagat ttgcattggt taccatgcaa acaactcgac agagcaggtt      120

gacacaataa tggaaaagaa tgtcactgtt acacacgccc aagacatact ggaaaagaca      180

cacaacggga aactctgcaa tctagatgga gtgaagcctc tcattttgag agattgtagt      240

gtagctggat ggctcctcgg gaacccaatg tgcgatgaat tcctcaatgt gccggaatgg      300

tcttacatag tggagaaaat caatccagcc aatgacctct gttatccagg gaatttcaac      360

gactatgaag aactgaaaca cctattgagc agaataaacc attttgagaa aattcagatc      420

attcccaaag attcttggtc agatcatgaa gcctcgggag tgagctcagc atgcccatac      480

caaggaagat cctccttttt tagaaatgtt gtatggctta ccaaaaagaa cgatgcatac      540

ccaacaataa agaaaagtta caataatact aaccaagaag atcttttggt actatggggg      600

attcaccatc caaatgatgc tgcagagcag acaaggcttt atcaaaaccc aactacctat      660

atctccgttg ggacatcaac actaaaccag agattggtac ccaaaatagc tactagatct      720

aaggtaaacg ggcaaagtgg aaggatggag ttcttttgga caattttaaa atcgaatgat      780

gcaataaact ttgagagcaa tggaaacttc attgctccag aaaatgcata caaaattgtc      840

aagaaaggag attcaacaat tatgaaaagt gagttggaat atagtaactg caacaccaag      900

tgtcagactc caataggggc gataaactcc agtatgccat tccacaacat ccaccctctc      960

accatcgggg aatgccccaa atatgtgaaa tcaaacagat tagtccttgc tactgggctc     1020

aggaatagcc ctcaaggaga gaaaagaaga aaaaagagag gactattcgg agccatagca     1080

ggctttatag agggaggatg gcagggaatg gtagatggtt ggtatgggta ccaccatagc     1140

aacgagcagg ggagtgggta cgctgcagac aaagaatcca ctcaaagggc tatagatgga     1200

gtcaccaata aggtcaattc gatcattgac aaaatgaaca ctcaggacga ggctgttgga     1260

agggaattta ataacttaga aaggagaata gaaaatttaa acaagaagat ggaagacgga     1320

ttcctagatg tctggactta taatgctgaa cttctggttc tcatggaaaa tgagagaact     1380

ctagactttc atgactcaaa tgtcaagaat ctttatgaca aggtccgact acagcttagg     1440

gataatgcaa aggagcttgg taacggttgt ttcgagttct atcacagatg tgataatgaa     1500

tgtatggaaa gtgtaagaaa cggaacgtat gactaccctc aatattcaga agaagcaaga     1560

ttaaaaagag aggaaataag tggagtaaaa ttggagtcaa taggaactta ccaaatactg     1620

tcaatttatt caacagtggc gagctcccta gcactggcaa tcatggtggc tggtctatct     1680

ttatggatgt gctccaatgg atcgctacaa tgcagaattt gcatttaa                  1728


<210>  80
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H5 Egypt-F392D AA

<400>  80

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asn Leu Asp Gly Val Lys Pro Leu Ile Leu Arg Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Leu Asn 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ile Asn Pro Ala Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile Ile Pro Lys Asp 
    130                 135                 140                 


Ser Trp Ser Asp His Glu Ala Ser Gly Val Ser Ser Ala Cys Pro Tyr 
145                 150                 155                 160 


Gln Gly Arg Ser Ser Phe Phe Arg Asn Val Val Trp Leu Thr Lys Lys 
                165                 170                 175     


Asn Asp Ala Tyr Pro Thr Ile Lys Lys Ser Tyr Asn Asn Thr Asn Gln 
            180                 185                 190         


Glu Asp Leu Leu Val Leu Trp Gly Ile His His Pro Asn Asp Ala Ala 
        195                 200                 205             


Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly 
    210                 215                 220                 


Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg Ser 
225                 230                 235                 240 


Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe Phe Trp Thr Ile Leu 
                245                 250                 255     


Lys Ser Asn Asp Ala Ile Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala 
            260                 265                 270         


Pro Glu Asn Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Thr Ile Met 
        275                 280                 285             


Lys Ser Glu Leu Glu Tyr Ser Asn Cys Asn Thr Lys Cys Gln Thr Pro 
    290                 295                 300                 


Ile Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro Leu 
305                 310                 315                 320 


Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg Leu Val Leu 
                325                 330                 335     


Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly Glu Lys Arg Arg Lys Lys 
            340                 345                 350         


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly 
    370                 375                 380                 


Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Arg Ala Ile Asp Gly 
385                 390                 395                 400 


Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Asp 
                405                 410                 415     


Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn 
            420                 425                 430         


Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His 
    450                 455                 460                 


Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg 
465                 470                 475                 480 


Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Arg 
                485                 490                 495     


Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr 
            500                 505                 510         


Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly 
        515                 520                 525             


Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr Ser 
    530                 535                 540                 


Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser 
545                 550                 555                 560 


Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575 


<210>  81
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-N382A DNA

<400>  81
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  82
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-N382A AA

<400>  82

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  83
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L384V DNA

<400>  83
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tcttcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

ttaaactcca aatacccagc attaaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgca      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aagggatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaga caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggctt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg agtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  84
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Switz-L384V AA

<400>  84

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ser Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Ser Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  85
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn-CysTm DNA

<400>  85
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggaaaaaa ctgcactcta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagag atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacgatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

tcaaacttca aatacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acagacaagg accaaatctt cctgtacgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aaggaatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacaaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg aaggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcttta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  86
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn-CysTm AA

<400>  86

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Arg Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asp Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Ser Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Gln Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Lys Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  87
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn-N382A-CysTm DNA

<400>  87
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggaaaaaa ctgcactcta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagag atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacgatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

tcaaacttca aatacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acagacaagg accaaatctt cctgtacgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aaggaatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacaaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg aaggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctggctcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcttta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  88
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn-N382A-CysTm AA

<400>  88

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Arg Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asp Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Ser Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Gln Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Lys Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Ala Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  89
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn-L384V-CysTm DNA

<400>  89
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaaaact tcctggaaat gacaatagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgaccg aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggaaaaaa ctgcactcta atagatgctc tattgggaga ccctcagtgt      300

gatggctttc aaaataagag atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacgatga aagcttcaat tgggctggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggggatc taatagtagt ttctttagta gattaaattg gttgacccac      540

tcaaacttca aatacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acagacaagg accaaatctt cctgtacgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aaggaatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacaaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaagtctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg aaggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg agtgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtaga agggagaatt caggaccttg agaaatatgt tgaggacaca     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactgagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacaggga tgaagcttta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atcccttgta ctgttagttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  90
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-H3 Penn-L384V-CysTm AA

<400>  90

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Arg Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asp Glu Ser Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Gly Ser Asn Ser Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Ser Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Gln Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Lys Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Val Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Ser Leu Val Leu Leu Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  91
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  91

Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Lys Ser Ser 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Val Pro Asn Asn Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Arg Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  92
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  92

Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Ser 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  93
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  93

Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Ser 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Lys Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Val Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Glu Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  94
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  94

Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Lys Asn Glu Ser Phe Asn Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Ser 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Lys Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Val Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Glu Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  95
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  95

Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Lys Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Arg Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asp Glu Ser Phe Asn Trp Ala 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Gly Ser Asn 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Ser Asn Phe Lys 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Gln Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Lys Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  96
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  96

Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Ile Arg Gly Ser Asn 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Ser Lys 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Arg Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  97
<211>  550
<212>  PRT
<213>  Alphainfluenza A virus

<400>  97

Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
        35                  40                  45              


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Arg Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Ile Arg Gly Ser Asn 
    130                 135                 140                 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Ser Lys 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Lys Pro Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Arg Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CysTM sequence (aa)

<400>  98

Ser Leu Val Leu Leu 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native TMCT (aa)

<400>  99

Cys Phe Leu Leu Cys 
1               5   


<210>  100
<211>  15
<212>  DNA
<213>  Artificial equence

<220>
<223>  CysTM sequence (nt)

<400>  100
tcccttgtac tgtta                                                        15


<210>  101
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native TMCT (nt)

<400>  101
tgttttttgc tttgt                                                        15


<210>  102
<211>  1701
<212>  DNA
<213>  Alphainfluenza A virus

<400>  102
atgaagacta tcattgcttt gagctacatt ctatgtctgg ttttcgctca aaaaattcct       60

ggaaatgaca atagcacggc aacgctgtgc cttgggcacc atgcagtacc aaacggaacg      120

atagtgaaaa caatcacgaa tgaccgaatt gaagttacta atgctactga gctggttcag      180

aattcctcaa taggtgaaat atgcgacagt cctcatcaga tccttgatgg agaaaactgc      240

acactaatag atgctctatt gggagaccct cagtgtgatg gctttcaaaa taagaaatgg      300

gacctttttg ttgaacgaag caaagcctac agcaactgtt acccttatga tgtgccggat      360

tatgcctccc ttaggtcact agttgcctca tccggcacac tggagtttaa caatgaaagc      420

ttcaattgga ctggagtcac tcaaaacgga acaagttctg cttgcataag gagatctagt      480

agtagtttct ttagtagatt aaattggttg acccacttaa actacacata cccagcattg      540

aacgtgacta tgccaaacaa tgaacaattt gacaaattgt acatttgggg ggttcaccac      600

ccgggtacgg acaaggacca aatcttcctg tatgctcaat catcaggaag aatcacagta      660

tctaccaaaa gaagccaaca agctgtaatc ccaaatatcg gatctagacc cagaataagg      720

gatatcccta gcagaataag catctattgg acaatagtaa aaccgggaga catacttttg      780

attaacagca cagggaatct aattgctcct aggggttact tcaaaatacg aagtgggaaa      840

agctcaataa tgagatcaga tgcacccatt ggcaaatgca agtctgaatg catcactcca      900

aatggaagca ttcccaatga caaaccattc caaaatgtaa acaggatcac atacggggcc      960

tgtcccagat atgttaagca tagcactctg aaattggcaa caggaatgcg aaatgtacca     1020

gagaaacaaa ctagaggcat atttggcgca atagcgggtt tcatagaaaa tggttgggag     1080

ggaatggtgg atggttggta cggtttcagg catcaaaatt ctgagggaag aggacaagca     1140

gcagatctca aaagcactca agcagcaatc gatcaaatca atgggaagct gaatcgattg     1200

atcgggaaaa ccaacgagaa attccatcag attgaaaaag aattctcaga agtagaagga     1260

agaattcagg accttgagaa atatgttgag gacactaaaa tagatctctg gtcatacaac     1320

gcggagcttc ttgttgccct ggagaaccaa catacaattg atctaactga ctcagaaatg     1380

aacaaactgt ttgaaaaaac aaagaagcaa ctgagggaaa atgctgagga tatgggcaat     1440

ggttgtttca aaatatacca caaatgtgac aatgcctgca taggatcaat aagaaatgga     1500

acttatgacc acaatgtgta cagggatgaa gcattaaaca accggttcca gatcaaggga     1560

gttgagctga agtcagggta caaagattgg atcctatgga tttcctttgc catatcatgt     1620

tttttgcttt gtgttgcttt gttggggttc atcatgtggg cctgccaaaa gggcaacatt     1680

aggtgcaaca tttgcatttg a                                               1701


<210>  103
<211>  3108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 2801 from 2X35S prom to NOS term

<400>  103
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gcgaaaaacg ttgcgatttt cggcttattg ttttctcttc ttgtgttggt      960

tccttctcag atcttcgcgc aaaaacttcc tggaaatgac aatagcacgg caacgctgtg     1020

ccttgggcac catgcagtac caaacggaac gatagtgaaa acaatcacga atgaccgaat     1080

tgaagttact aatgctactg agctggttca gaattcctca ataggtgaaa tatgcgacag     1140

tcctcatcag atccttgatg gagaaaactg cacactaata gatgctctat tgggagaccc     1200

tcagtgtgat ggctttcaaa ataagaaatg ggaccttttt gttgaacgaa gcaaagccta     1260

cagcaactgt tacccttatg atgtgccgga ttatgcctcc cttaggtcac tagttgcctc     1320

atccggcaca ctggagttta acaatgaaag cttcaattgg gctggagtca ctcaaaacgg     1380

aacaagttct tcttgcataa ggggatctaa tagtagtttc tttagtagat taaattggtt     1440

gacccactta aactccaaat acccagcatt aaacgtgact atgccaaaca atgaacaatt     1500

tgacaaattg tacatttggg gggttcacca cccgggtacg gacaaggacc aaatcttcct     1560

gtatgcacaa tcatcaggaa gaatcacagt atctaccaaa agaagccaac aagctgtaat     1620

cccgaatatc ggatctagac ccagaataag ggatatccct agcagaataa gcatctattg     1680

gacaatagta aaaccgggag acatactttt gattaacagc acagggaatc taattgctcc     1740

taggggttac ttcaaaatac gaagtgggaa aagctcaata atgagatcag atgcacccat     1800

tggcaaatgc aagtctgaat gcatcactcc aaatggaagc attcccaatg acaaaccatt     1860

ccaaaatgta aacaggatca catacggggc ctgtcccaga tatgttaagc aaagcactct     1920

gaaattggca acaggaatgc gaaatgtacc agagagacaa actagaggca tatttggcgc     1980

aatagcgggt ttcatagaaa atggttggga gggaatggtg gatggttggt acggcttcag     2040

gcatcaaaat tctgagggaa gaggacaagc agcagatctc aaaagcactc aagcagcaat     2100

cgatcaaatc aatgggaagc tgaatcgatt gatcgggaaa accaacgaga aattccatca     2160

gattgaaaaa gaattctcag aagtagaagg gagaattcag gaccttgaga aatatgttga     2220

ggacacaaaa atagatctct ggtcatacaa cgcggagctt cttgttgccc tggagaacca     2280

acatacaatt gatctaactg actcagaaat gaacaaactg tttgaaaaaa caaagaagca     2340

actgagggaa aatgctgagg atatgggcaa tggttgtttc aaaatatacc acaaatgtga     2400

caatgcctgc ataggatcaa tcagaaatgg aacttatgac cacgatgtat acagggatga     2460

agcattaaac aaccggttcc agatcaaggg agttgagctg aagtcagggt acaaagattg     2520

gatcctatgg atttcctttg ccatatcatg ttttttgctt tgtgttgctt tgttggggtt     2580

catcatgtgg gcctgccaaa agggcaacat taggtgcaac atttgcattt gaaggcctat     2640

tttctttagt ttgaatttac tgttattcgg tgtgcatttc tatgtttggt gagcggtttt     2700

ctgtgctcag agtgtgttta ttttatgtaa tttaatttct ttgtgagctc ctgtttagca     2760

ggtcgtccct tcagcaagga cacaaaaaga ttttaatttt attaaaaaaa aaaaaaaaaa     2820

agaccgggaa ttcgatatca agcttatcga cctgcagatc gttcaaacat ttggcaataa     2880

agtttcttaa gattgaatcc tgttgccggt cttgcgatga ttatcatata atttctgttg     2940

aattacgtta agcatgtaat aattaacatg taatgcatga cgttatttat gagatgggtt     3000

tttatgatta gagtcccgca attatacatt taatacgcga tagaaaacaa aatatagcgc     3060

gcaaactagg ataaattatc gcgcgcggtg tcatctatgt tactagat                  3108


<210>  104
<211>  3108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 3023 from 2X35S prom to NOS term

<400>  104
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gcgaaaaacg ttgcgatttt cggcttattg ttttctcttc ttgtgttggt      960

tccttctcag atcttcgcgc aaaaacttcc tggaaatgac aatagcacgg caacgctgtg     1020

ccttgggcac catgcagtac caaacggaac gatagtgaaa acaatcacga atgaccgaat     1080

tgaagttact aatgctactg agctggttca gaattcctca ataggtgaaa tatgcgacag     1140

tcctcatcag atccttgatg gagaaaactg cacactaata gatgctctat tgggagaccc     1200

tcagtgtgat ggctttcaaa ataagaaatg ggaccttttt gttgaacgaa gcaaagccta     1260

cagcaactgt tacccttatg atgtgccgga ttatgcctcc cttaggtcac tagttgcctc     1320

atccggcaca ctggagttta acaatgaaag cttcaattgg gctggagtca ctcaaaacgg     1380

aacaagttct tcttgcataa ggggatctaa tagtagtttc tttagtagat taaattggtt     1440

gacccactta aactccaaat acccagcatt aaacgtgact atgccaaaca atgaacaatt     1500

tgacaaattg tacatttggg gggttcacca cccgggtacg gacaaggacc aaatcttcct     1560

gtatgcacaa tcatcaggaa gaatcacagt atctaccaaa agaagccaac aagctgtaat     1620

cccgaatatc ggatctagac ccagaataag ggatatccct agcagaataa gcatctattg     1680

gacaatagta aaaccgggag acatactttt gattaacagc acagggaatc taattgctcc     1740

taggggttac ttcaaaatac gaagtgggaa aagctcaata atgagatcag atgcacccat     1800

tggcaaatgc aagtctgaat gcatcactcc aaatggaagc attcccaatg acaaaccatt     1860

ccaaaatgta aacaggatca catacggggc ctgtcccaga tatgttaagc aaagcactct     1920

gaaattggca acaggaatgc gaaatgtacc agagagacaa actagaggca tatttggcgc     1980

aatagcgggt ttcatagaaa atggttggga gggaatggtg gatggttggt acggcttcag     2040

gcatcaaaat tctgagggaa gaggacaagc agcagatctc aaaagcactc aagcagcaat     2100

cgatcaaatc aatgggaagc tggctcgatt gatcgggaaa accaacgaga aattccatca     2160

gattgaaaaa gaattctcag aagtagaagg gagaattcag gaccttgaga aatatgttga     2220

ggacacaaaa atagatctct ggtcatacaa cgcggagctt cttgttgccc tggagaacca     2280

acatacaatt gatctaactg actcagaaat gaacaaactg tttgaaaaaa caaagaagca     2340

actgagggaa aatgctgagg atatgggcaa tggttgtttc aaaatatacc acaaatgtga     2400

caatgcctgc ataggatcaa tcagaaatgg aacttatgac cacgatgtat acagggatga     2460

agcattaaac aaccggttcc agatcaaggg agttgagctg aagtcagggt acaaagattg     2520

gatcctatgg atttcctttg ccatatcatg ttttttgctt tgtgttgctt tgttggggtt     2580

catcatgtgg gcctgccaaa agggcaacat taggtgcaac atttgcattt gaaggcctat     2640

tttctttagt ttgaatttac tgttattcgg tgtgcatttc tatgtttggt gagcggtttt     2700

ctgtgctcag agtgtgttta ttttatgtaa tttaatttct ttgtgagctc ctgtttagca     2760

ggtcgtccct tcagcaagga cacaaaaaga ttttaatttt attaaaaaaa aaaaaaaaaa     2820

agaccgggaa ttcgatatca agcttatcga cctgcagatc gttcaaacat ttggcaataa     2880

agtttcttaa gattgaatcc tgttgccggt cttgcgatga ttatcatata atttctgttg     2940

aattacgtta agcatgtaat aattaacatg taatgcatga cgttatttat gagatgggtt     3000

tttatgatta gagtcccgca attatacatt taatacgcga tagaaaacaa aatatagcgc     3060

gcaaactagg ataaattatc gcgcgcggtg tcatctatgt tactagat                  3108


<210>  105
<211>  3108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 2811 from 2X35S prom to NOS term

<400>  105
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gcgaaaaacg ttgcgatttt cggcttattg ttttctcttc ttgtgttggt      960

tccttctcag atcttcgcgc aaaaacttcc tggaaatgac aatagcacgg caacgctgtg     1020

ccttgggcac catgcagtac caaacggaac gatagtgaaa acaatcacga atgaccgaat     1080

tgaagttact aatgctactg agctggttca gaattcctca ataggtgaaa tatgcgacag     1140

tcctcatcag atccttgatg gagaaaactg cacactaata gatgctctat tgggagaccc     1200

tcagtgtgat ggctttcaaa ataagaaatg ggaccttttt gttgaacgaa gcaaagccta     1260

cagcaactgt tacccttatg atgtgccgga ttatgcctcc cttaggtcac tagttgcctc     1320

atccggcaca ctggagttta acaatgaaag cttcaattgg gctggagtca ctcaaaacgg     1380

aacaagttct tcttgcataa ggggatctaa tagtagtttc tttagtagat taaattggtt     1440

gacccactta aactccaaat acccagcatt aaacgtgact atgccaaaca atgaacaatt     1500

tgacaaattg tacatttggg gggttcacca cccgggtacg gacaaggacc aaatcttcct     1560

gtatgcacaa tcatcaggaa gaatcacagt atctaccaaa agaagccaac aagctgtaat     1620

cccgaatatc ggatctagac ccagaataag ggatatccct agcagaataa gcatctattg     1680

gacaatagta aaaccgggag acatactttt gattaacagc acagggaatc taattgctcc     1740

taggggttac ttcaaaatac gaagtgggaa aagctcaata atgagatcag atgcacccat     1800

tggcaaatgc aagtctgaat gcatcactcc aaatggaagc attcccaatg acaaaccatt     1860

ccaaaatgta aacaggatca catacggggc ctgtcccaga tatgttaagc aaagcactct     1920

gaaattggca acaggaatgc gaaatgtacc agagagacaa actagaggca tatttggcgc     1980

aatagcgggt ttcatagaaa atggttggga gggaatggtg gatggttggt acggcttcag     2040

gcatcaaaat tctgagggaa gaggacaagc agcagatctc aaaagcactc aagcagcaat     2100

cgatcaaatc aatgggaagc tgaatcgatt gatcgggaaa accaacgaga aattccatca     2160

gattgaaaaa gaattctcag aagtagaagg gagaattcag gaccttgaga aatatgttga     2220

ggacacaaaa atagatctct ggtcatacaa cgcggagctt cttgttgccc tggagaacca     2280

acatacaatt gatctaactg actcagaaat gaacaaactg tttgaaaaaa caaagaagca     2340

actgagggaa aatgctgagg atatgggcaa tggttgtttc aaaatatacc acaaatgtga     2400

caatgcctgc ataggatcaa tcagaaatgg aacttatgac cacgatgtat acagggatga     2460

agcattaaac aaccggttcc agatcaaggg agttgagctg aagtcagggt acaaagattg     2520

gatcctatgg atttcctttg ccatatcatc ccttgtactg ttagttgctt tgttggggtt     2580

catcatgtgg gcctgccaaa agggcaacat taggtgcaac atttgcattt gaaggcctat     2640

tttctttagt ttgaatttac tgttattcgg tgtgcatttc tatgtttggt gagcggtttt     2700

ctgtgctcag agtgtgttta ttttatgtaa tttaatttct ttgtgagctc ctgtttagca     2760

ggtcgtccct tcagcaagga cacaaaaaga ttttaatttt attaaaaaaa aaaaaaaaaa     2820

agaccgggaa ttcgatatca agcttatcga cctgcagatc gttcaaacat ttggcaataa     2880

agtttcttaa gattgaatcc tgttgccggt cttgcgatga ttatcatata atttctgttg     2940

aattacgtta agcatgtaat aattaacatg taatgcatga cgttatttat gagatgggtt     3000

tttatgatta gagtcccgca attatacatt taatacgcga tagaaaacaa aatatagcgc     3060

gcaaactagg ataaattatc gcgcgcggtg tcatctatgt tactagat                  3108


