                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  COMPOSITIONS AND METHODS TO TARGET CLL-1 AND CD123 FOR THE 
       TREATMENT OF ACUTE MYELOID LEUKEMIA AND RELATED DISORDERS

<130>  F053-0102PCT/17-031-WO-PCT

<140>  PCT/US2019/038596
<141>  2019-06-21

<150>  US 62/688,674
<151>  2018-06-22

<160>  267   

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  2
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met Lys Ala 
1               5                   10                  15      


Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr Asp Ile 
            20                  25                  30          


Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn Asn Ser 
        35                  40                  45              


Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn Tyr Thr 
    50                  55                  60                  


Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe Pro Glu 
65                  70                  75                  80  


Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys Trp Ile 
                85                  90                  95      


His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro Gly Ala 
            100                 105                 110         


Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn Arg Arg 
        115                 120                 125             


Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly Thr Arg 
    130                 135                 140                 


Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly Ser Gln 
145                 150                 155                 160 


Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly Ile Pro 
                165                 170                 175     


Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu Thr Pro 
            180                 185                 190         


Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met His Trp 
        195                 200                 205             


Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu Gln Ile 
    210                 215                 220                 


Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp Arg Thr 
225                 230                 235                 240 


Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile Arg Ala 
                245                 250                 255     


Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro Gln Arg 
            260                 265                 270         


Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp Arg Thr 
        275                 280                 285             


Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys Val Phe 
    290                 295                 300                 


Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro Arg Ile 
305                 310                 315                 320 


Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp Lys Leu 
                325                 330                 335     


Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu Val Thr 
            340                 345                 350         


Glu Val Gln Val Val Gln Lys Thr 
        355                 360 


<210>  3
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain (ECD) of CD123 Target

<400>  3

Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met Lys Ala 
1               5                   10                  15      


Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr Asp Ile 
            20                  25                  30          


Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn Asn Ser 
        35                  40                  45              


Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn Tyr Thr 
    50                  55                  60                  


Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe Pro Glu 
65                  70                  75                  80  


Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys Trp Ile 
                85                  90                  95      


His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro Gly Ala 
            100                 105                 110         


Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn Arg Arg 
        115                 120                 125             


Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly Thr Arg 
    130                 135                 140                 


Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly Ser Gln 
145                 150                 155                 160 


Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly Ile Pro 
                165                 170                 175     


Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu Thr Pro 
            180                 185                 190         


Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met His Trp 
        195                 200                 205             


Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu Gln Ile 
    210                 215                 220                 


Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp Arg Thr 
225                 230                 235                 240 


Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile Arg Ala 
                245                 250                 255     


Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro Gln Arg 
            260                 265                 270         


Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp Arg 
        275                 280                 285         


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane Domain (TM) of CD123 Target

<400>  4

Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys Val 
1               5                   10                  15      


Phe Val Ile Cys 
            20  


<210>  5
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic Domain (CPD) of CD123 Target

<400>  5

Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro Arg Ile Pro His Met 
1               5                   10                  15      


Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp Lys Leu Val Val Trp 
            20                  25                  30          


Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu Val Thr Glu Val Gln 
        35                  40                  45              


Val Val Gln Lys Thr 
    50              


<210>  6
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu 
        35                  40                  45              


Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe 
    50                  55                  60                  


His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
65                  70                  75                  80  


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
                85                  90                  95      


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
            100                 105                 110         


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
        115                 120                 125             


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
    130                 135                 140                 


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
145                 150                 155                 160 


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
                165                 170                 175     


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
            180                 185                 190         


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
        195                 200                 205             


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
    210                 215                 220                 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
225                 230                 235                 240 


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
                245                 250                 255     


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
            260                 265 


<210>  7
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic domain from CLL-1 Target

<400>  7

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala 
        35                  40              


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain of CLL-1 target

<400>  8

Leu Phe Leu Thr Leu Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val 
1               5                   10                  15      


Leu Ala Ser Met Phe 
            20      


<210>  9
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of CLL-1 target

<400>  9

His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
1               5                   10                  15      


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
            20                  25                  30          


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
        35                  40                  45              


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
    50                  55                  60                  


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
65                  70                  75                  80  


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
                85                  90                  95      


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
            100                 105                 110         


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
        115                 120                 125             


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
    130                 135                 140                 


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
145                 150                 155                 160 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
                165                 170                 175     


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
            180                 185                 190         


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
        195                 200     


<210>  10
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 CAR construct

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg 
    450                 455                 460                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
465                 470                 475                 480 


Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
                485                 490                 495     


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            500                 505                 510         


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        515                 520                 525             


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    530                 535                 540                 


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
545                 550                 555                 560 


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                565                 570                 575     


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            580                 585                 590         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        595                 600                 605             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    610                 615                 620                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
625                 630                 635                 640 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                645                 650                 655     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            660                 665                 670         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        675                 680                 685             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    690                 695                 700                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
705                 710                 715                 720 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                725                 730                 735     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            740                 745                 750         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        755                 760                 765             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    770                 775                 780                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
785                 790                 795                 800 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                805                 810                 815     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            820                 825                 830         


Ile Gly Leu Phe Met 
        835         


<210>  11
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv for CAR schematic

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  12
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  12

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Arg Ser Leu Arg Glu Cys Glu Leu Tyr Val 
            260                 265                 270         


Gln Lys His Asn Ile Gln Ala Leu Leu Lys Asp Arg Ile Val Gln Leu 
        275                 280                 285             


Cys Thr Ala Arg Pro Glu Arg Pro Met Ala Phe Leu Arg Glu Tyr Phe 
    290                 295                 300                 


Glu Arg Leu Glu Lys Glu Glu Ala Lys Met Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu 
                485                 490                 495     


Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly Pro Arg 
        515                 


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of CLL-1

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of CLL-1

<400>  14

Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  15

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            260                 265                 270         


Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Arg Ser Leu Arg 
    290                 295                 300                 


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
305                 310                 315                 320 


Asp Arg Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
                325                 330                 335     


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Val 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu 
            500                 505                 510         


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        515                 520                 525             


Pro Arg 
    530 


<210>  16
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  16

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            260                 265                 270         


Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Arg Ser Leu Arg 
    290                 295                 300                 


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
305                 310                 315                 320 


Asp Arg Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
                325                 330                 335     


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Val 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu 
            500                 505                 510         


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        515                 520                 525             


Pro Arg 
    530 


<210>  17
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental CAR T cell Vector

<400>  17

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
            180                 185                 190         


Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly 
        195                 200                 205             


Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu 
225                 230                 235                 240 


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr 
                245                 250                 255     


Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
        275                 280                 285             


Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
    290                 295                 300                 


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
305                 310                 315                 320 


Ala Lys Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly 
            500                 505                 510         


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
        515                 520                 525             


Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
    530                 535                 540                 


Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile 
545                 550                 555                 560 


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
                565                 570                 575     


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
            580                 585                 590         


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
        595                 600                 605             


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
    610                 615                 620                 


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
625                 630                 635                 640 


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
                645                 650                 655     


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
            660                 665                 670         


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
        675                 680                 685             


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
    690                 695                 700                 


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
705                 710                 715                 720 


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
                725                 730                 735     


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
            740                 745                 750         


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
        755                 760                 765             


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
    770                 775                 780                 


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
785                 790                 795                 800 


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
                805                 810                 815     


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
            820                 825                 830         


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
        835                 840                 845             


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
    850                 855                 860                 


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
865                 870                 875                 880 


Gly Ile Gly Leu Phe Met Ala Leu Glu Ser 
                885                 890 


<210>  18
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of scFv targeting CD123

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  19
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of scFv targeting CD123

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  20
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR for homodimeric targeting of CD123

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
            180                 185                 190         


Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly 
        195                 200                 205             


Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu 
225                 230                 235                 240 


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr 
                245                 250                 255     


Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
        275                 280                 285             


Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
    290                 295                 300                 


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
305                 310                 315                 320 


Ala Lys 
        


<210>  21
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR for homodimeric targeting of CD123

<400>  21
ctcgagacca tggagaccga tacactgctg ctgtgggtgc tgctgctgtg ggtgcctggc       60

agcaccggcg acatcgtgat gacacagagc ccaagctccc tggccgtgtc cgtgggagag      120

aaggtgacca tgtcctgcaa gtctagccag tctctgctgt tctcctctaa ccagaagaat      180

tacctggcct ggtatcagca gaagccaggc cagagcccca agctgctgat ctactgggcc      240

agcacccggg agtccggcgt gccagataga ttcaccggct ccggctctgg cacagacttt      300

accctgacaa tcagctccgt gaaggccgag gatctggccg tgtactattg ccagcagttc      360

tattcctttc ccaggacctt tggcggcggc acaaagctgg agatcaagag gggaggagga      420

ggcagcggcg gaggaggctc cggaggcggc ggctctggcg gcggcggcag cgaggtgcag      480

ctggtggagt ctggaggagg actggtgaag cctggaggct ctctgaagct gagctgtgcc      540

gcctccggct tcaccttttc tagctacgcc atgagctggg tgaggcagac accagagaag      600

cgcctggagt gggtggcaac cgtgtcttat ggcggcagct acacattcta tcctgataac      660

gtgaagggca ggtttaccat ctcccgcgac aatgccaaga acaatctgta cctgcagatg      720

tcccacctga agtctgagga tacagccatg tactattgtg cccgggacta cgattatgac      780

ttctttgact cctggggcca gggcaccaca gtgaccgtgt cctctagcct gagagagtgc      840

gagctgtacg tgcagaagca caacatccag gccctgctga aggactctat cgtgcagctg      900

tgcacagcaa ggccagagag acctatggcc ttcctgcggg agtattttga gagactggag      960

aaggaggagg ccaagcacca ccaccaccac cactaatgag gatcc                     1005


<210>  22
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of scFv targeting CD123 coding sequence

<400>  22
gacatcgtga tgacacagag cccaagctcc ctggccgtgt ccgtgggaga gaaggtgacc       60

atgtcctgca agtctagcca gtctctgctg ttctcctcta accagaagaa ttacctggcc      120

tggtatcagc agaagccagg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagtccggcg tgccagatag attcaccggc tccggctctg gcacagactt taccctgaca      240

atcagctccg tgaaggccga ggatctggcc gtgtactatt gccagcagtt ctattccttt      300

cccaggacct ttggcggcgg cacaaagctg gagatcaaga gg                         342


<210>  23
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of scFv targeting CD123 coding sequence

<400>  23
gaggtgcagc tggtggagtc tggaggagga ctggtgaagc ctggaggctc tctgaagctg       60

agctgtgccg cctccggctt caccttttct agctacgcca tgagctgggt gaggcagaca      120

ccagagaagc gcctggagtg ggtggcaacc gtgtcttatg gcggcagcta cacattctat      180

cctgataacg tgaagggcag gtttaccatc tcccgcgaca atgccaagaa caatctgtac      240

ctgcagatgt cccacctgaa gtctgaggat acagccatgt actattgtgc ccgggactac      300

gattatgact tctttgactc ctggggccag ggcaccacag tgaccgtgtc ctct            354


<210>  24
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR for heterodimeric targeting of CLL1

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        195                 200                 205             


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe 
                245                 250                 255     


Gly Pro Gly Thr Lys Val Glu Ile Lys Ser Leu Arg Glu Cys Glu Leu 
            260                 265                 270         


Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys Asp Glu Ile Val 
        275                 280                 285             


Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala Phe Leu Arg Glu 
    290                 295                 300                 


Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys His His His His His 
305                 310                 315                 320 


His Gly Ser 
            


<210>  25
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR for heterodimeric targeting of CLL1

<400>  25
ctcgagacca tggagaccga cacactgctg ctgtgggtgc tgctgctgtg ggtgcctggc       60

agcaccggac aggtgcagct gcaggagtcc ggacctggac tggtgaagcc aagcgagacc      120

ctgtccctga catgcgtggt gtctggcggc agcatcagct cctctaactg gtggtcctgg      180

gtgagacagc cacctggcaa gggcctggag tggatcggcg agatctacca cagcggctcc      240

cccgactata acccttccct gaagtctagg gtgaccatct ctgtggataa gagccgcaat      300

cagttctctc tgaagctgag ctccgtgacc gcagcagaca cagccgtgta ctattgcgcc      360

aaggtgagca caggcggctt ctttgattac tggggccagg gcaccctggt gacagtgtct      420

agcggaggag gaggcagcgg aggaggaggc tccggcggcg gcggctctga gatcgagctg      480

acccagtccc catcctctct gtctgccagc gtgggcgaca gggtgaccat cacatgtaga      540

gcctcccagt ctatcagctc ctacctgaac tggtatcagc agaagccagg caaggccccc      600

aagctgctga tctatgcagc ctctagcctg cagtccggcg tgccctctcg gttcagcggc      660

tccggctctg gcaccgactt taccctgaca atctcctctc tgcagcccga ggatttcgcc      720

acatactatt gtcagcagag ctactccacc ccacccacat ttggccctgg caccaaggtg      780

gagatcaaga gcctgcggga gtgcgagctg tatgtgcaga agcacaatat ccaggccctg      840

ctgaaggatg agatcgtgca gctgtgcaca gcccggcctg agagaccaat ggccttcctg      900

agggagtact ttgagcgcct ggagaaggag gaggccaagc accaccacca ccaccactaa      960

tgaggatcc                                                              969


<210>  26
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of scFv targeting CLL1 coding sequence

<400>  26
caggtgcagc tgcaggagtc cggacctgga ctggtgaagc caagcgagac cctgtccctg       60

acatgcgtgg tgtctggcgg cagcatcagc tcctctaact ggtggtcctg ggtgagacag      120

ccacctggca agggcctgga gtggatcggc gagatctacc acagcggctc ccccgactat      180

aacccttccc tgaagtctag ggtgaccatc tctgtggata agagccgcaa tcagttctct      240

ctgaagctga gctccgtgac cgcagcagac acagccgtgt actattgcgc caaggtgagc      300

acaggcggct tctttgatta ctggggccag ggcaccctgg tgacagtgtc tagc            354


<210>  27
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of scFv targeting CLL1 coding sequence

<400>  27
gagatcgagc tgacccagtc cccatcctct ctgtctgcca gcgtgggcga cagggtgacc       60

atcacatgta gagcctccca gtctatcagc tcctacctga actggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctatgca gcctctagcc tgcagtccgg cgtgccctct      180

cggttcagcg gctccggctc tggcaccgac tttaccctga caatctcctc tctgcagccc      240

gaggatttcg ccacatacta ttgtcagcag agctactcca ccccacccac atttggccct      300

ggcaccaagg tggagatcaa g                                                321


<210>  28
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR for heterodimeric targeting of CD123

<400>  28

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
            180                 185                 190         


Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly 
        195                 200                 205             


Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu 
225                 230                 235                 240 


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr 
                245                 250                 255     


Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
        275                 280                 285             


Leu Leu Lys Asp Arg Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
    290                 295                 300                 


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
305                 310                 315                 320 


Ala Lys His His His His His His Gly Ser 
                325                 330 


<210>  29
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR for heterodimeric targeting of CD123

<400>  29
ctcgagacca tggagaccga tacactgctg ctgtgggtgc tgctgctgtg ggtgcctggc       60

agcaccggcg acatcgtgat gacacagagc ccaagctccc tggccgtgtc cgtgggagag      120

aaggtgacca tgtcctgcaa gtctagccag tctctgctgt tctcctctaa ccagaagaat      180

tacctggcct ggtatcagca gaagccaggc cagagcccca agctgctgat ctactgggcc      240

agcacccggg agtccggcgt gccagataga ttcaccggct ccggctctgg cacagacttt      300

accctgacaa tcagctccgt gaaggccgag gatctggccg tgtactattg ccagcagttc      360

tattcctttc ccaggacctt tggcggcggc acaaagctgg agatcaagag gggaggagga      420

ggcagcggcg gaggaggctc cggaggcggc ggctctggcg gcggcggcag cgaggtgcag      480

ctggtggagt ctggaggagg actggtgaag cctggaggct ctctgaagct gagctgtgcc      540

gcctccggct tcaccttttc tagctacgcc atgagctggg tgaggcagac accagagaag      600

cgcctggagt gggtggcaac cgtgtcttat ggcggcagct acacattcta tcctgataac      660

gtgaagggca ggtttaccat ctcccgcgac aatgccaaga acaatctgta cctgcagatg      720

tcccacctga agtctgagga tacagccatg tactattgtg cccgggacta cgattatgac      780

ttctttgact cttggggcca gggcaccaca gtgaccgtgt cctctagcct gcgggagtgc      840

gagctgtacg tgcagaagca caacatccag gccctgctga aggacagaat cgtgcagctg      900

tgcacagcaa ggccagagag acctatggcc ttcctgcggg agtattttga gagactggag      960

aaggaggagg ccaagcacca ccaccaccac cactaatgag gatcc                     1005


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  30

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln 
        


<210>  31
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  31

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  33
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgK signal peptide

<400>  33
atggagaccg atacactgct gctgtgggtg ctgctgctgt gggtgcctgg cagcaccggc       60


<210>  34
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgK signal peptide

<400>  34
atggagaccg acacactgct gctgtgggtg ctgctgctgt gggtgcctgg cagcaccgga       60


<210>  35
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  35
atggagaccg atacactgct gctgtgggtg ctgctgctgt gggtgccagg ctccaccggc       60


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  36

Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  37

Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 linker

<400>  38

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  39
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain of CD28

<400>  39

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25          


<210>  40
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain of CD28

<400>  40

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25      


<210>  41
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  41

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40              


<210>  42
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB cytoplasmic domain

<400>  42

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        35                  40      


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z

<400>  43

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  44
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z cytoplasmic domain

<400>  44

Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            20                  25                  30          


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        35                  40                  45              


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  45
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR

<400>  45

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser 
305                 310         


<210>  46
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain of EGFR

<400>  46

Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
1               5                   10                  15      


Leu Gly Ile Gly Leu Phe Met 
            20              


<210>  47
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFRt

<400>  47

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  48
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNL Linker

<400>  48

Arg Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln 
1               5                   10                  15      


Ala Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu 
            20                  25                  30          


Arg Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu 
        35                  40                  45              


Glu Ala Lys 
    50      


<210>  49
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNL S31R Linker

<400>  49

Arg Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln 
1               5                   10                  15      


Ala Leu Leu Lys Asp Arg Ile Val Gln Leu Cys Thr Ala Arg Pro Glu 
            20                  25                  30          


Arg Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu 
        35                  40                  45              


Glu Ala Lys 
    50      


<210>  50
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRKAR1A based DNL

<400>  50

Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
            20                  25                  30          


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
        35                  40                  45              


Ala Lys 
    50  


<210>  51
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNL Linker

<400>  51
agcctgaggg agtgcgagct gtacgtgcag aagcacaata tccaggccct gctgaaggat       60

tccatcgtgc agctgtgcac cgcaaggcct gagaggccaa tggccttcct gagggagtac      120

tttgagaagc tggagaag                                                    138


<210>  52
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRKAR1A based DNL

<400>  52
agcctgagag agtgcgagct gtacgtgcag aagcacaaca tccaggccct gctgaaggac       60

tctatcgtgc agctgtgcac agcaaggcca gagagaccta tggccttcct gcgggagtat      120

tttgagagac tggagaagga ggaggccaag                                       150


<210>  53
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRKAR1E based DNL

<400>  53

Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Glu Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
            20                  25                  30          


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
        35                  40                  45              


Ala Lys 
    50  


<210>  54
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRKAR1E based DNL

<400>  54
agcctgcggg agtgcgagct gtatgtgcag aagcacaata tccaggccct gctgaaggat       60

gagatcgtgc agctgtgcac agcccggcct gagagaccaa tggccttcct gagggagtac      120

tttgagcgcc tggagaagga ggaggccaag                                       150


<210>  55
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRKAR1R based DNL

<400>  55

Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Arg Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
            20                  25                  30          


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
        35                  40                  45              


Ala Lys 
    50  


<210>  56
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRKAR1R based DNL

<400>  56
agcctgcggg agtgcgagct gtacgtgcag aagcacaaca tccaggccct gctgaaggac       60

agaatcgtgc agctgtgcac agcaaggcca gagagaccta tggccttcct gcgggagtat      120

tttgagagac tggagaagga ggaggccaag                                       150


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Linker

<400>  57

Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10      


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  58

His His His His His His 
1               5       


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  59
caccaccacc accaccac                                                     18


<210>  60
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  61
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Ser Pro Pro Ala Cys Pro Ser Glu Glu Asp Glu Ser Leu Lys 
1               5                   10                  15      


Gly Cys Glu Leu Tyr Val Gln Leu His Gly Ile Gln Gln Val Leu Lys 
            20                  25                  30          


Asp Cys Ile Val His Leu Cys Ile Ser Lys Pro Glu Arg Pro Met Lys 
        35                  40                  45              


Phe Leu Arg Glu His Phe Glu Lys Leu Glu Lys Glu Glu Asn Arg Gln 
    50                  55                  60                  


Ile Leu Ala Arg Gln Lys Ser Asn Ser Gln Ser Asp Ser His Asp Glu 
65                  70                  75                  80  


Glu Val Ser Pro Thr Pro Pro Asn Pro Val Val Lys Ala Arg Arg Arg 
                85                  90                  95      


Arg Gly Gly Val Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Val Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Thr Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Ser Lys Asn Val Leu Phe Ala His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Pro Val Thr His Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asn Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Val Asp Gln Gly Glu Val Asp Val Tyr Val Asn Gly Glu Trp Val Thr 
            180                 185                 190         


Asn Ile Ser Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asp Leu Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Glu Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Glu Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Asp Phe Tyr Ile Ile Thr Glu Gly Thr Ala Ser Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Pro Asn Glu Glu Tyr Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Leu Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Glu Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Arg Tyr Asn Ser Phe Ile Ser Leu Thr Val 
    370                 375                 380     


<210>  62
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge

<400>  62

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  63
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge

<400>  63
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag      360

gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaagatg                                       690


<210>  64
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  short spacer

<400>  64
aatctaagta cggaccgccc tgcccccctt gccct                                  35


<210>  65
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intermediate spacer

<400>  65

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  66
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge region containing CH2 and CH3 regions

<400>  66

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  67
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRKAR1B based DNL


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<400>  67
skgcyvhgvk dcvhcskrmk rhkknr                                            26


<210>  68
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization and docking domain 1

<400>  68

Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210>  69
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization and docking domain 2

<400>  69

Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anchoring domain 1

<400>  70

Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210>  71
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anchoring domain 2

<400>  71

Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 domain

<400>  72

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Trp His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Pro Phe Lys Phe Met 
        35                  40                  45              


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    50                  55                  60                  


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
65                  70                  75                  80  


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                85                  90                  95      


Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105     


<210>  73
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR

<400>  73

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  74
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
1               5                   10                  15      


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30          


Leu Lys Gln Lys Val Met Asn 
        35                  


<210>  75
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  75

Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Lys Lys 
1               5                   10                  15      


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            20                  25                  30          


Leu Glu Phe Ile Leu Ala Ala 
        35                  


<210>  76
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents either a Lys or Arg amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa represents any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa represents either a Tyr or Phe amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa represents either a Tyr or Phe amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa represents any amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa represents either an Asp or Asn amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa represents any amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa represents any amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa represents either a Thr or Ser amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa represents either a Lys or Arg amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa represents any amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa represents either a Thr or Ser amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa represents either a Thr, Ser, or Gln amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa represents any amino acid residue.

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa represents any amino acid residue.

<400>  76

Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Pro 
            20                  25      


<210>  77
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  77

Trp Arg Glu Phe Cys Glu Ser His Ala Arg Ala Ala Ala Leu Asp Phe 
1               5                   10                  15      


Ala Arg Arg Phe Arg Leu Tyr Leu Ala Ser His Pro Gln Tyr Ala Gly 
            20                  25                  30          


Pro Gly Ala Glu Ala Ala Phe Ser Arg Arg Phe Ala Glu Leu Phe Leu 
        35                  40                  45              


Gln His Phe Glu Ala Glu Val Ala Arg Ala Ser 
    50                  55                  


<210>  78
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  78

Thr His Arg Ala Ile Phe Arg Phe Val Pro Arg His Glu Asp Glu Leu 
1               5                   10                  15      


Glu Leu Glu Val Asp Asp Pro Leu Leu Val Glu Leu Gln Ala Glu Asp 
            20                  25                  30          


Tyr Trp Tyr Glu Ala Tyr Asn Met Arg Thr Gly Ala Arg Gly Val Phe 
        35                  40                  45              


Pro Ala Tyr Tyr Ala Ile Glu 
    50                  55  


<210>  79
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  79

Leu Gly Glu Val His Arg Phe His Val Thr Val Ala Pro Gly Thr Lys 
1               5                   10                  15      


Leu Glu Ser Gly Pro Ala Thr Leu His Leu Cys Asn Asp Val Leu Val 
            20                  25                  30          


Leu Ala Arg Asp Ile Pro Pro Ala Val Thr Gly Gln Trp Lys Leu Ser 
        35                  40                  45              


Asp Leu Arg Arg Tyr Gly Ala Val Pro Ser Gly Phe Ile Phe Glu Gly 
    50                  55                  60                  


Gly Thr Arg Cys Gly Tyr Trp Ala Gly Val Phe Phe Leu Ser Ser Ala 
65                  70                  75                  80  


Glu Gly Glu Gln Ile Ser Phe Leu Phe Asp Cys Ile Val Arg Gly Ile 
                85                  90                  95      


Ser Pro Thr Lys Gly 
            100     


<210>  80
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  80

Asp Cys Lys Glu Glu His Ala Glu Phe Val Leu Val Arg Lys Asp Met 
1               5                   10                  15      


Leu Phe Asn Gln Leu Ile Glu Met Ala Leu Leu Ser Leu Gly Tyr Ser 
            20                  25                  30          


His Ser Ser Ala Ala Gln Ala Lys Gly Leu Ile Gln Val Gly Lys Trp 
        35                  40                  45              


Asn Pro Val Pro Leu Ser Tyr Val Thr Asp Ala Pro Asp Ala Thr Val 
    50                  55                  60                  


Ala Asp Met Leu Gln Asp Val Tyr His Val Val Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Leu His Ser Cys Pro Lys Leu Glu Asp Leu Pro Pro Glu Gln Trp Ser 
                85                  90                  95      


His Thr Thr Val Arg Asn Ala Leu Lys Asp Leu Leu Lys Asp Met Asn 
            100                 105                 110         


Gln Ser Ser 
        115 


<210>  81
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  81

Cys Ala Pro Trp Pro Met Val Glu Lys Leu Ile Lys Gln Cys Leu Lys 
1               5                   10                  15      


Glu Asn Pro Gln Glu Arg Pro Thr Ser Ala Gln Val Phe Asp Ile Leu 
            20                  25                  30          


Asn Ser Ala Glu Leu Val Cys Leu Thr Arg Arg Ile Leu Leu Pro Lys 
        35                  40                  45              


Asn Val Ile Val Glu Cys Met Val Ala Thr His His Asn Ser Arg Asn 
    50                  55                  60                  


Ala Ser Ile Trp Leu Gly Cys Gly His Thr Asp Arg Gly Gln Leu Ser 
65                  70                  75                  80  


Phe Leu Asp Leu Asn Thr Glu Gly Tyr Thr Ser Glu Glu Val Ala Asp 
                85                  90                  95      


Ser Arg Ile Leu Cys Leu Ala Leu Val His Leu Pro Val Glu Lys Glu 
            100                 105                 110         


Ser Trp Ile Val Ser Gly Thr Gln Ser Gly Thr Leu Leu Val Ile Asn 
        115                 120                 125             


Thr Glu Asp Gly Lys Lys Arg His Thr Leu Glu Lys Met Thr Asp Ser 
    130                 135                 140                 


Val Thr Cys Leu Tyr Cys Asn Ser Phe Ser Lys Gln Ser Lys Gln Lys 
145                 150                 155                 160 


Asn Phe Leu Leu Val Gly Thr Ala Asp Gly Lys Leu Ala Ile Phe Glu 
                165                 170                 175     


Asp Lys Thr Val Lys Leu Lys Gly Ala Ala Pro Leu Lys Ile Leu Asn 
            180                 185                 190         


Ile Gly Asn Val Ser Thr Pro Leu Met Cys Leu Ser Glu Ser Thr Asn 
        195                 200                 205             


Ser Thr Glu Arg Asn Val Met Trp Gly Gly Cys Gly Ser Gln Leu Phe 
    210                 215                 220                 


Ser Tyr Ala Ala Phe Ser Asp Ser Asn Ile Ile Thr Val Val Val Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Ile Ala Lys Gln Asn Ser Pro Val Val Glu Val Trp 
                245                 250                 255     


Asp Lys Lys Thr Glu Lys Leu Cys Gly Leu Ile Asp Cys Val His Phe 
            260                 265                 270         


Leu Arg Glu Val Met Val Lys Glu Thr Lys Ile Phe Ser Phe Ser Asn 
        275                 280                 285             


Asp Phe Thr Ile Gln Lys Leu Ile Glu Thr Arg Thr Asn Lys Glu Ser 
    290                 295                 300                 


Lys His Lys Met Ser Tyr Ser Gly Arg Val Lys Thr Leu Cys Leu Gln 
305                 310                 315                 320 


Lys Asn Thr Ala Leu Trp Ile Gly Thr Gly Gly Gly His Ile Leu Leu 
                325                 330                 335     


Leu Asp Leu Ser Thr Arg Arg Leu Ile Arg Val Ile Tyr Asn Phe Cys 
            340                 345                 350         


Asn Ser Val Arg Val Met Met Thr Ala Gln Leu Gly Ser Leu Lys Asn 
        355                 360                 365             


Val Met Leu Val Leu Gly Tyr Asn Arg Lys Asn Thr Glu Gly Thr Gln 
    370                 375                 380                 


Lys Gln Lys Glu Ile Gln Ser Cys Leu Thr Val Trp Asp Ile Asn Leu 
385                 390                 395                 400 


Pro His Glu Val Gln Asn Leu Glu Lys His Ile Glu Val Arg Lys Glu 
                405                 410                 415     


Leu Ala Glu Lys Met Arg Arg Thr Ser Val Glu 
            420                 425         


<210>  82
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  82

Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
1               5                   10                  15      


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            20                  25                  30          


Val Thr Pro Val Leu Asn Gln Gln Gln Ser Glu Trp Phe Gly Ser Thr 
        35                  40                  45              


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    50                  55                  60                  


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg 
65                  70                  75  


<210>  83
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  83

Leu Ser Ala Lys Glu Thr Lys Met Leu Met Ala Ala Gly Asp Lys Asp 
1               5                   10                  15      


Gly Asp Gly Lys Ile Gly Val Asp Glu Phe Ser Thr Leu Val Ala Glu 
            20                  25                  30          


Ser 
    


<210>  84
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  84

Ser Gly Arg Ala His Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu Gln 
1               5                   10                  15      


Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp 
            20                  25                  30          


Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln 
        35                  40                  45              


Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu 
    50                  55                  60                  


Leu Val Pro Arg 
65              


<210>  85
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  85

Lys Lys Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile Gln 
1               5                   10                  15      


Ser Val Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr Leu 
            20                  25                  30          


Leu Glu Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val Glu 
        35                  40                  45              


Leu Gln Gly Leu Ser Lys Glu 
    50                  55  


<210>  86
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  86

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  87
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b Multimerization Domains

<400>  87

Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu 
1               5                   10                  15      


Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val 
            20                  25                  30          


Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser 
        35                  40                  45              


Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55              


<210>  88
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  88

Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn 
1               5                   10                  15      


Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu 
            20                  25                  30          


Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu 
        35                  40                  45              


Asp Lys Glu Leu 
    50          


<210>  89
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  89

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Tyr Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  90
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  90

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Ala Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  91
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  91

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Ala Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Trp Asp Lys Glu Leu 
    50                  55          


<210>  92
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  92

Glu Val Pro Glu Gly Cys Glu Gln Val Gln Ala Gly Arg Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Ala Asp Pro Tyr Glu Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Leu Leu Glu Leu Gln Arg Asp Lys Ala 
        35                  40                  45              


Arg Lys Ser Ser Val Leu Arg Gln Leu 
    50                  55          


<210>  93
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  93

Val Val Pro Glu Gly Cys Glu His Ile Leu Lys Gly Arg Lys Thr Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Ser Leu Asp Ile Glu Leu Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Lys Glu Ser Thr Val Gln Ser Pro Val 
    50                  55          


<210>  94
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  94

Glu Val Pro Lys Asp Cys Glu His Val Phe Ala Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Ser Asn Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Ile Lys Gln Leu Gln Leu Gln Ile Asp Lys Ala 
        35                  40                  45              


Lys His Val Asp Arg Glu Leu 
    50                  55  


<210>  95
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  95

Glu Tyr Pro Glu Asp Cys Glu Gln Val His Glu Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Leu Glu Glu Ile Lys Leu Ala Leu Glu Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Thr Lys Leu Leu Glu Leu Gln Ile Asp Lys Glu 
        35                  40                  45              


Lys Lys Ala Lys Ala Lys Tyr Ser Ile 
    50                  55          


<210>  96
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  96

Glu Tyr Pro Glu Asp Cys Glu Gln Val His Glu Gly Lys Lys Leu Met 
1               5                   10                  15      


Glu Cys Leu Pro Thr Leu Glu Glu Ile Lys Leu Ala Leu Ala Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Thr Asn Leu Leu Glu Leu Gln Ile Asp Lys Glu 
        35                  40                  45              


Lys Lys Ala Lys Ala Lys Tyr Ser Thr 
    50                  55          


<210>  97
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  97

Glu Ile Ala Glu Gly Cys Glu Gln Val Leu Ala Gly Arg Lys Ile Met 
1               5                   10                  15      


Gln Cys Leu Pro Lys Pro Glu Asp Val Arg Thr Ala Leu Glu Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Lys Lys Leu Glu Lys Glu 
        35                  40                  45              


Glu Lys Cys Thr Pro Glu Val Gln Glu 
    50                  55          


<210>  98
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  98

Glu Tyr Pro Glu Gly Cys Glu Gln Val Val Thr Gly Arg Lys Leu Leu 
1               5                   10                  15      


Gln Cys Leu Ser Arg Pro Glu Glu Val Lys Leu Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Ile Leu Gln Thr Asn Lys Leu Lys Lys 
        35                  40                  45              


Glu Ala Phe Leu Leu Arg Glu Arg Glu Lys Asn Val Thr Cys Asp Phe 
    50                  55                  60                  


Asn Pro Glu 
65          


<210>  99
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  99

Glu Tyr Pro Glu Gly Cys Glu Gln Val Val Thr Gly Arg Lys Leu Leu 
1               5                   10                  15      


Lys Cys Leu Ser Arg Pro Glu Glu Val Lys Leu Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Ala Leu Leu Glu Leu Gln Ile Asp Lys Pro 
        35                  40                  45              


Lys Asp Ala Ser 
    50          


<210>  100
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  100

Glu Val Pro Glu Asn Cys Glu Gln Val Ile Val Gly Lys Lys Leu Met 
1               5                   10                  15      


Lys Cys Leu Ser Asn Pro Asp Glu Ala Gln Met Ala Leu Gln Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ala Glu Leu Leu Arg Leu Gln Ile Val Lys Ala 
        35                  40                  45              


Arg Gln Gly Ser 
    50          


<210>  101
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  101

Glu Ala Ser Glu Asp Leu Lys Pro Ala Leu Thr Gly Asn Lys Thr Met 
1               5                   10                  15      


Gln Tyr Val Pro Asn Ser His Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Val Glu Leu Leu Gln Leu Gln Ile Gln Lys Glu 
        35                  40                  45              


Lys His Thr Glu Ala His 
    50                  


<210>  102
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  102

Val Ser Ala Glu Val Cys Glu Ala Val Phe Lys Gly Gln Lys Leu Leu 
1               5                   10                  15      


Lys Cys Leu Pro Asn Ala Met Glu Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Lys Leu Glu Gln Glu Lys Arg Lys Leu 
        35                  40                  45              


Glu Ile Ala 
    50      


<210>  103
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  103

Glu Val Pro Glu Glu Cys Lys Gln Val Ala Ala Gly Arg Lys Leu Leu 
1               5                   10                  15      


Glu Cys Leu Pro Asn Pro Ser Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Lys Glu Lys Tyr Val Lys 
        35                  40                  45              


Ile Gln Glu Lys Phe Ser Lys Lys Glu Met Lys Gln Leu Thr Ser Ala 
    50                  55                  60                  


Leu His 
65      


<210>  104
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  104

Glu Val Leu Glu Asp Cys Arg Ile Val Ser Arg Gly Ala Gln Leu Leu 
1               5                   10                  15      


His Cys Leu Ser Ser Pro Glu Asp Val His Arg Ala Leu Lys Val Tyr 
            20                  25                  30          


Lys Leu Phe Leu Glu Ile Glu Arg Leu Glu His Gln Lys Glu Lys Trp 
        35                  40                  45              


Ile Gln Leu His Arg Lys Pro Gln Ser Met Lys 
    50                  55                  


<210>  105
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  105

Glu Gly Pro Glu Asp Cys Glu Ile Val Asn Lys Gly Arg Gln Leu Leu 
1               5                   10                  15      


Gln Cys Leu Ser Ser Pro Glu Asp Val Gln Arg Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Arg Leu Glu Gln Gln Arg Glu Lys Arg 
        35                  40                  45              


Thr Ser Val His Arg Lys Ala His Tyr Thr Lys Val Asp Gly Pro 
    50                  55                  60              


<210>  106
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  106

Glu Ala Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Arg Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Ser Pro Glu Asp Val Lys Val Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Lys Glu Arg Asp Lys Leu 
        35                  40                  45              


Met Asn Thr His Gln Lys Phe Ser Glu Lys Glu Glu Met Lys Asp Leu 
    50                  55                  60                  


Phe Phe Pro 
65          


<210>  107
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  107

Glu Val Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Leu Leu Glu Leu Gln Ile Asp Lys Ala 
        35                  40                  45              


Arg Gln Gly Ser 
    50          


<210>  108
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  108

Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
1               5                   10                  15      


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
            20                  25                  30          


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser 
        35                  40                  45          


<210>  109
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  109

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser 
    50      


<210>  110
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  110

Gly Ser Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Ser Leu Pro 
1               5                   10                  15      


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
            20                  25                  30          


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
        35                  40                  45              


Leu Asp Lys Glu Leu 
    50              


<210>  111
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  111

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  112
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  112

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  113
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  113

Glu Gly Cys Glu Gln Ile Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
1               5                   10                  15      


Pro Asp Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr Lys Leu Ser 
            20                  25                  30          


Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Arg Ala Arg Gln Ser 
        35                  40                  45              


Thr Leu 
    50  


<210>  114
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  114

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  115
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  115

Glu Gly Cys Glu Gln Ile Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
1               5                   10                  15      


Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr Lys Leu Ser 
            20                  25                  30          


Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala Arg Gln Ser 
        35                  40                  45              


Thr Leu Asp Lys 
    50          


<210>  116
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  116

Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu 
1               5                   10                  15      


Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val 
            20                  25                  30          


Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser 
        35                  40                  45              


Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu Val Pro Arg 
    50                  55                  60      


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  117

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  118

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  119
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  119

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  120
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin tag

<400>  120

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  121

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  122

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  123
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  123

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  124

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  125

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  126
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  126

His Lys Asp Ser Cys Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln 
1               5                   10                  15      


Glu Ser Lys Met Ala Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile 
            20                  25                  30          


Asn Asn Lys Asn Ala Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr 
        35                  40                  45              


Asp Tyr Trp Leu Gly Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met 
    50                  55                  60                  


Arg Val Asp Asn Ile Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala 
65                  70                  75                  80  


Pro Asp Leu Asn Asn Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val 
                85                  90                  95      


Gln Tyr Tyr His Cys Thr Tyr Lys Lys Arg Met Ile Cys 
            100                 105                 


<210>  127
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of scFv targeting CD123

<400>  127
gacatcgtga tgacacagag ccccagctcc ctggccgtgt ccgtgggaga gaaggtgacc       60

atgtcttgca agtctagcca gagcctgctg ttttcctcta accagaagaa ttacctggcc      120

tggtatcagc agaagccagg ccagtccccc aagctgctga tctattgggc cagcaccaga      180

gagtccggcg tgcccgatag gttcaccggc tccggctctg gcacagactt taccctgaca      240

atcagctccg tgaaggccga ggacctggcc gtgtactatt gccagcagtt ctacagcttt      300

cctagaacct tcggcggcgg cacaaagctg gagatcaaga gg                         342


<210>  128
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of scFv targeting CD123

<400>  128
gaggtgcagc tggtggagag cggcggcggc ctggtgaagc ccggcggctc tctgaagctg       60

agctgtgccg cctccggctt caccttttct agctacgcca tgtcttgggt gagacagaca      120

cccgagaaga ggctggagtg ggtggccacc gtgtcttatg gcggcagcta cacattctat      180

cctgataacg tgaagggccg gttcaccatc agccgggaca atgccaagaa caatctgtat      240

ctgcagatgt cccacctgaa gtctgaggat acagccatgt actattgcgc cagagactac      300

gattatgact tctttgacag ctggggccag ggcaccacag tgacagtgtc ctct            354


<210>  129
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgD hinge

<400>  129

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  130
<211>  847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgD hinge

<400>  130
aggtggcccg aaagtcccaa ggcccaggca tctagtgttc ctactgcaca gccccaggca       60

gaaggcagcc tagccaaagc tactactgca cctgccacta cgcgcaatac tggccgtggc      120

ggggaggaga agaaaaagga gaaagagaaa gaagaacagg aagagaggga gaccaagacc      180

cctgaatgtc catcccatac ccagccgctg ggcgtctatc tcttgactcc cgcagtacag      240

gacttgtggc ttagagataa ggccaccttt acatgtttcg tcgtgggctc tgacctgaag      300

gatgcccatt tgacttggga ggttgccgga aaggtaccca cagggggggt tgaggaaggg      360

ttgctggagc gccattccaa tggctctcag agccagcact caagactcac ccttccgaga      420

tccctgtgga acgccgggac ctctgtcaca tgtactctaa atcatcctag cctgccccca      480

cagcgtctga tggcccttag agagccagcc gcccaggcac cagttaagct tagcctgaat      540

ctgctcgcca gtagtgatcc cccagaggcc gccagctggc tcttatgcga agtgtccggc      600

tttagcccgc ccaacatctt gctcatgtgg ctggaggacc agcgagaagt gaacaccagc      660

ggcttcgctc cagcccggcc cccaccccag ccgggttcta ccacattctg ggcctggagt      720

gtcttaaggg tcccagcacc acctagcccc cagccagcca catacacctg tgttgtgtcc      780

catgaagata gcaggaccct gctaaatgct tctaggagtc tggaggtttc ctacgtgact      840

gaccatt                                                                847


<210>  131
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFV-DNL_5HVZ-His Forward primer

<400>  131
ctacggctag caccatggag accg                                              24


<210>  132
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFV-DNL_5HVZ-His reverse primer

<400>  132
cacccaaaag gatcccttgg cctcctcctt ctccagtctc tc                          42


<210>  133
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 scFv

<400>  133
gacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc       60

atcagctgcc gggccagcca ggacatcagc aagtacctga actggtatca gcagaagccc      120

gacggcaccg tcaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag      240

gaagatatcg ccacctactt ttgccagcag ggcaacacac tgccctacac ctttggcggc      300

ggaacaaagc tggaaatcac cggcagcacc tccggcagcg gcaagcctgg cagcggcgag      360

ggcagcacca agggcgaggt gaagctgcag gaaagcggcc ctggcctggt ggcccccagc      420

cagagcctga gcgtgacctg caccgtgagc ggcgtgagcc tgcccgacta cggcgtgagc      480

tggatccggc agccccccag gaagggcctg gaatggctgg gcgtgatctg gggcagcgag      540

accacctact acaacagcgc cctgaagagc cggctgacca tcatcaagga caacagcaag      600

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      660

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      720

gtgaccgtga gcagc                                                       735


<210>  134
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 scFv

<400>  134

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  135
<211>  1246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lachnospiraceae bacterium ND2006 Reference Sequence

<400>  135

Met Leu Lys Asn Val Gly Ile Asp Arg Leu Asp Val Glu Lys Gly Arg 
1               5                   10                  15      


Lys Asn Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Ile Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Arg Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His 
    1235                 1240                 1245     


<210>  136
<211>  1274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidaminococcus sp. BV3L6 Reference Sequence

<400>  136

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Val Val Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Lys  Arg Pro Ala 
    1220                 1225                 1230             


Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys Lys Lys  Gly Ser Tyr 
    1235                 1240                 1245             


Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp 
    1250                 1255                 1260             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala 
    1265                 1270                 


<210>  137
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMCSFRss-CD19scFv-IgG4hinge-CD28TM-41BB-zeta-T2A-EGFRt

<400>  137

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly 
        275                 280                 285             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    290                 295                 300                 


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
305                 310                 315                 320 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                325                 330                 335     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly 
    450                 455                 460                 


Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
465                 470                 475                 480 


Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys 
                485                 490                 495     


Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn 
            500                 505                 510         


Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr 
        515                 520                 525             


Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His 
    530                 535                 540                 


Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro 
545                 550                 555                 560 


Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr 
                565                 570                 575     


Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His 
            580                 585                 590         


Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly 
        595                 600                 605             


Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu 
    610                 615                 620                 


Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn 
625                 630                 635                 640 


Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly 
                645                 650                 655     


Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser 
            660                 665                 670         


Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly 
        675                 680                 685             


Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser 
    690                 695                 700                 


Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro 
705                 710                 715                 720 


Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys 
                725                 730                 735     


Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn 
            740                 745                 750         


Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr 
        755                 760                 765             


Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr 
    770                 775                 780                 


Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr 
785                 790                 795                 800 


Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys 
                805                 810                 815     


Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu 
            820                 825                 830         


Val Val Ala Leu Gly Ile Gly Leu Phe Met 
        835                 840         


<210>  138
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 scFv

<400>  138

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu 
                165                 170                 175     


Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr 
            180                 185                 190         


Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Glu Asp 
    210                 215                 220                 


Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp 
225                 230                 235                 240 


Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250         


<210>  139
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 scFv

<400>  139

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag

<400>  140

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag II

<400>  141

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  142
<211>  3993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  142
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcgagtctaa gtacggaccg      840

ccctgccccc cttgccctat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc      900

tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa      960

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1020

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc     1080

agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg     1140

aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag     1200

atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1260

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag     1320

ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg     1380

cacatgcagg ccctgccccc aaggctcgag ggcggcggag agggcagagg aagtcttcta     1440

acatgcggtg acgtggagga gaatcccggc cctaagctta tgctgctgct cgtgaccagc     1500

ctgctgctgt gcgaactgcc ccaccctgcc tttctgctga tcccccaggt gcagctgcag     1560

gaatctggcc ctggcctcgt gaagcccagc gagacactga gcctgacctg tgtggtgtcc     1620

ggcggcagca tcagcagctc caattggtgg tcttgggtgc gccagcctcc tggcaagggc     1680

ctggaatgga tcggcgagat ctaccacagc ggcagccccg actacaaccc cagcctgaag     1740

tccagagtga ccatcagcgt ggacaagagc cggaaccagt tctccctgaa gctgagcagc     1800

gtgacagccg ccgataccgc cgtgtactac tgcgccaaag tgtccaccgg cggctttttc     1860

gactactggg gccagggcac actcgtgacc gtgtctagcg gaggcggagg atctggcgga     1920

gggggctccg gagggggagg ctctgaaatt gagctgaccc agagccccag cagcctgtct     1980

gcctctgtgg gcgaccgcgt gaccattacc tgtagagcca gccagagcat cagctcctac     2040

ctgaactggt atcagcagaa gcccggcaag gcccccaaac tgctgatcta cgccgccagc     2100

tctctgcagt ctggcgtgcc cagcagattt tccggcagcg gctctggcac cgacttcacc     2160

ctgaccatct ccagcctgca gcccgaggac ttcgccacct actactgcca gcagagctac     2220

agcacccccc ccacatttgg cccaggcacc aaggtggaaa tcaaagagtc taagtacgga     2280

ccgccctgcc ccccttgccc tatgttctgg gtgctggtgg tggtcggagg cgtgctggcc     2340

tgctacagcc tgctggtcac cgtggccttc atcatctttt gggtgaaacg gggcagaaag     2400

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     2460

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgggtgaag     2520

ttcagcagaa gcgccgacgc ccctgcctac cagcagggcc agaatcagct gtacaacgag     2580

ctgaacctgg gcagaaggga agagtacgac gtcctggata agcggagagg ccgggaccct     2640

gagatgggcg gcaagcctcg gcggaagaac ccccaggaag gcctgtataa cgaactgcag     2700

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcggggc     2760

aagggccacg acggcctgta tcagggcctg tccaccgcca ccaaggatac ctacgacgcc     2820

ctgcacatgc aggccctgcc cccaaggctc gagggcggcg gagagggcag aggaagtctt     2880

ctaacatgcg gtgacgtgga ggagaatccc ggccctagga tgcttctcct ggtgacaagc     2940

cttctgctct gtgagttacc acacccagca ttcctcctga tcccacgcaa agtgtgtaac     3000

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     3060

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     3120

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     3180

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     3240

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     3300

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     3360

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     3420

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     3480

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     3540

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     3600

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     3660

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     3720

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     3780

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     3840

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     3900

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     3960

gtggtggccc tggggatcgg cctcttcatg tga                                  3993


<210>  143
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  143

Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
            180                 185                 190         


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr 
        195                 200                 205             


Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His 
225                 230                 235                 240 


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp 
                245                 250                 255     


Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            260                 265                 270         


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr 
465                 470                 475                 480 


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Lys Leu Met Leu Leu Leu 
                485                 490                 495     


Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu 
            500                 505                 510         


Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
        515                 520                 525             


Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser 
    530                 535                 540                 


Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
545                 550                 555                 560 


Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro 
                565                 570                 575     


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln 
            580                 585                 590         


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
        595                 600                 605             


Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln 
    610                 615                 620                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser 
                645                 650                 655     


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
            660                 665                 670         


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
        675                 680                 685             


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
    690                 695                 700                 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
705                 710                 715                 720 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
                725                 730                 735     


Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu 
            740                 745                 750         


Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe 
        755                 760                 765             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    770                 775                 780                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
785                 790                 795                 800 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                805                 810                 815     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            820                 825                 830         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        835                 840                 845             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    850                 855                 860                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
865                 870                 875                 880 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                885                 890                 895     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            900                 905                 910         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        915                 920                 925             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    930                 935                 940                 


Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu 
945                 950                 955                 960 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu 
                965                 970                 975     


Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu 
            980                 985                 990         


Ile Pro Arg Lys Val Cys Asn Gly  Ile Gly Ile Gly Glu  Phe Lys Asp 
        995                 1000                 1005             


Ser Leu  Ser Ile Asn Ala Thr  Asn Ile Lys His Phe  Lys Asn Cys 
    1010                 1015                 1020             


Thr Ser  Ile Ser Gly Asp Leu  His Ile Leu Pro Val  Ala Phe Arg 
    1025                 1030                 1035             


Gly Asp  Ser Phe Thr His Thr  Pro Pro Leu Asp Pro  Gln Glu Leu 
    1040                 1045                 1050             


Asp Ile  Leu Lys Thr Val Lys  Glu Ile Thr Gly Phe  Leu Leu Ile 
    1055                 1060                 1065             


Gln Ala  Trp Pro Glu Asn Arg  Thr Asp Leu His Ala  Phe Glu Asn 
    1070                 1075                 1080             


Leu Glu  Ile Ile Arg Gly Arg  Thr Lys Gln His Gly  Gln Phe Ser 
    1085                 1090                 1095             


Leu Ala  Val Val Ser Leu Asn  Ile Thr Ser Leu Gly  Leu Arg Ser 
    1100                 1105                 1110             


Leu Lys  Glu Ile Ser Asp Gly  Asp Val Ile Ile Ser  Gly Asn Lys 
    1115                 1120                 1125             


Asn Leu  Cys Tyr Ala Asn Thr  Ile Asn Trp Lys Lys  Leu Phe Gly 
    1130                 1135                 1140             


Thr Ser  Gly Gln Lys Thr Lys  Ile Ile Ser Asn Arg  Gly Glu Asn 
    1145                 1150                 1155             


Ser Cys  Lys Ala Thr Gly Gln  Val Cys His Ala Leu  Cys Ser Pro 
    1160                 1165                 1170             


Glu Gly  Cys Trp Gly Pro Glu  Pro Arg Asp Cys Val  Ser Cys Arg 
    1175                 1180                 1185             


Asn Val  Ser Arg Gly Arg Glu  Cys Val Asp Lys Cys  Asn Leu Leu 
    1190                 1195                 1200             


Glu Gly  Glu Pro Arg Glu Phe  Val Glu Asn Ser Glu  Cys Ile Gln 
    1205                 1210                 1215             


Cys His  Pro Glu Cys Leu Pro  Gln Ala Met Asn Ile  Thr Cys Thr 
    1220                 1225                 1230             


Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys Ala His  Tyr Ile Asp 
    1235                 1240                 1245             


Gly Pro  His Cys Val Lys Thr  Cys Pro Ala Gly Val  Met Gly Glu 
    1250                 1255                 1260             


Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp Ala Gly  His Val Cys 
    1265                 1270                 1275             


His Leu  Cys His Pro Asn Cys  Thr Tyr Gly Cys Thr  Gly Pro Gly 
    1280                 1285                 1290             


Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys Ile Pro  Ser Ile Ala 
    1295                 1300                 1305             


Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu Leu Val  Val Ala Leu 
    1310                 1315                 1320             


Gly Ile  Gly Leu Phe Met 
    1325                 


<210>  144
<211>  3972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  144
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctgca agagtctggc cctggactgg tcaagcctag cgagacactg      120

agcctgacct gtgtggtgtc tggcggcagc atcagcagct ccaattggtg gtcttgggtc      180

cgacagcctc ctggcaaagg cctggaatgg atcggcgaga tctaccactc tggcagcccc      240

gactacaacc ccagcctgaa aagcagagtg accatcagcg tggacaagag ccggaaccag      300

ttcagcctga agctgagcag cgtgacagcc gccgatacag ccgtgtacta ctgtgccaaa      360

gtgtccaccg gcggcttttt cgactattgg ggccagggca cactggtcac agtttctagc      420

ggaggcggag gatctggtgg cggaggaagt ggcggaggcg gctctgaaat tgagctgaca      480

cagagcccta gcagcctgtc tgcctctgtg ggcgacagag tgacaattac ctgcagagcc      540

agccagagca tcagctccta cctgaattgg tatcagcaaa agcccggcaa ggcccctaaa      600

ctgctgatct atgccgccag ctctctgcag tctggcgtgc caagcagatt ttctggcagc      660

ggctctggca ccgacttcac cctgaccata tctagcctgc agcctgagga cttcgccacc      720

tactactgcc agcagagcta cagcacccct cctacatttg gccctggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccttgt cctccttgtc caatgttctg ggtgctcgtg      840

gttgttggcg gagtgctggc ctgttacagc ctgctggtta ccgtggcctt catcatcttt      900

tgggtcaagc ggggcagaaa gaagctgctg tacatcttca agcagccctt catgcggccc      960

gtgcagacca cacaagagga agatggctgc tcctgcagat tccccgagga agaagaaggc     1020

ggctgcgagc tgagagtgaa gttcagcaga tccgccgacg ctcctgccta tcagcaggga     1080

cagaaccagc tgtacaacga gctgaacctg gggagaagag aagagtacga cgtgctggac     1140

aagcggagag gcagagatcc tgagatgggc ggcaagccca gacggaagaa tcctcaagag     1200

ggcctgtata atgagctgca gaaagacaag atggccgagg cctacagcga gatcggaatg     1260

aagggcgagc gcagaagagg caagggacac gatggactgt accagggact gagcaccgcc     1320

accaaggata cctatgacgc cctgcacatg caggcccttc cacctagagg ttccggagcc     1380

accaacttta gcctgctgaa acaggccggc gacgtggaag agaaccctgg acctatgctg     1440

ctcctcgtga caagcctgct cctgtgtgaa ctccctcatc cagcatttct gctcatcccc     1500

gacatcgtga tgactcagag cccaagctct ctggccgtgt ccgtgggaga gaaagtgacc     1560

atgtcctgca agtctagcca gtctctgctg ttcagcagca accagaagaa ctacctggcc     1620

tggtatcaac agaagcctgg acagtcccca aagctgctca tctactgggc cagcaccaga     1680

gaaagcggcg tgcccgatag attcacaggc tctggaagcg gcacagattt cacactgaca     1740

atcagctccg tgaaggccga ggacctggct gtgtactatt gtcagcagtt ctacagcttc     1800

cccagaacct tcggcggagg caccaagctc gagatcaaaa gaggtggcgg aggttcaggc     1860

ggaggtggta gtggtggtgg cggttctggc ggtggcggaa gcgaagttca actggtggaa     1920

tctggcggcg gactcgtgaa acctggcggc tctctgaaac tgtcctgtgc cgcctctggc     1980

ttcaccttca gcagctacgc catgagctgg gtccgccaaa cacctgagaa gcggctggaa     2040

tgggtcgcca cagtgtccta cggcggaagc tacacattct accccgacaa tgtgaagggc     2100

agattcacca tctccagaga caacgccaag aacaacctgt acctccagat gagccacctg     2160

aagtccgagg ataccgccat gtattactgc gccagagact acgactacga tttcttcgac     2220

agctggggac agggaaccac cgtgacagtg tccagcgaga gcaaatacgg ccctccatgt     2280

ccgccatgtc ctatgttttg ggtcctcgtt gtcgtcggag gcgtgctggc atgctattct     2340

ctgcttgtga cagtcgcctt tattatcttc tgggttaaga gaggccggaa gaagctcctc     2400

tatatcttta aacagccgtt tatgcgcccg gtccagacta cccaagaaga ggacggctgt     2460

agctgtcggt tccctgaaga ggaagaaggc ggttgcgaac tgcgcgtgaa attctccaga     2520

agcgctgacg cccctgctta ccagcaaggc cagaatcagc tctataacga actcaatctc     2580

ggcaggcgcg aggaatatga tgtgctggat aagaggcgcg gcagggaccc agagatggga     2640

ggaaagcctc ggagaaagaa cccacaagaa ggcctttaca acgaactgca aaaggataag     2700

atggcagaag cttactccga gattggcatg aagggcgaac gtcggagagg aaaaggccac     2760

gacggactct atcagggcct gtctaccgcc acaaaagaca catacgatgc actccatatg     2820

caggctctgc ctccaagagg atccggcgaa ggcagaggtt ctctgctgac atgcggagat     2880

gtggaagaaa atcccgggcc aatgctcctg ctcgtgactt cactgctgct ctgtgaattg     2940

ccacatccgg cttttttgct cattccacgg aaagtgtgca acggcatcgg catcggagag     3000

ttcaaggaca gcctgtccat caacgccacc aacatcaagc acttcaagaa ctgcaccagc     3060

atctccggcg acctgcacat tctgcctgtg gcctttagag gcgacagctt cacccacaca     3120

cctccactgg accctcaaga gctggacatc ctgaaaaccg tgaaagagat caccggattt     3180

ctgcttattc aagcctggcc tgagaacagg accgatctgc acgccttcga gaacctggaa     3240

atcatcagag gcaggaccaa gcagcacggc cagtttagcc tggcagtggt gtccctgaac     3300

atcaccagcc tgggactgag aagcctgaaa gaaatctccg atggcgacgt gatcatcagc     3360

ggcaacaaga acctgtgcta cgccaacacc atcaactgga agaaactgtt cggcaccagc     3420

ggccagaaaa caaagatcat ctccaaccgg ggcgagaact cctgcaaggc tacaggccaa     3480

gtgtgccacg ctctgtgtag ccctgaaggc tgttggggac ccgagcctag agattgcgtg     3540

tcctgcagaa acgtgtcccg gggcagagaa tgtgtggaca agtgcaacct gctggaaggc     3600

gagccccgcg agtttgtgga aaacagcgag tgcatccagt gtcaccccga gtgtctgccc     3660

caggccatga atatcacctg taccggcaga ggccctgaca actgtattca gtgcgcccac     3720

tacatcgacg gccctcactg cgtgaaaaca tgtccagcag gcgtgatggg cgaaaacaac     3780

accctcgtgt ggaagtatgc cgacgccgga catgtgtgcc acctgtgtca ccctaattgc     3840

acctacggct gtaccggacc aggactggaa ggctgcccta caaacggccc taagatcccc     3900

tctatcgcca ccggaatggt tggagccctg ctgcttctgc tggtggttgc ccttggcatc     3960

ggactgttta tg                                                         3972


<210>  145
<211>  1324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  145

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu 
465                 470                 475                 480 


Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
                485                 490                 495     


Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            500                 505                 510         


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        515                 520                 525             


Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    530                 535                 540                 


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
545                 550                 555                 560 


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                565                 570                 575     


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            580                 585                 590         


Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
            660                 665                 670         


Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly 
        675                 680                 685             


Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu 
705                 710                 715                 720 


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr 
                725                 730                 735     


Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            740                 745                 750         


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val 
        755                 760                 765             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    770                 775                 780                 


Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu 
785                 790                 795                 800 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                805                 810                 815     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            820                 825                 830         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        835                 840                 845             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    850                 855                 860                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
865                 870                 875                 880 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                885                 890                 895     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            900                 905                 910         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        915                 920                 925             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    930                 935                 940                 


Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
945                 950                 955                 960 


Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser Leu Leu 
                965                 970                 975     


Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val 
            980                 985                 990         


Cys Asn Gly Ile Gly Ile Gly Glu  Phe Lys Asp Ser Leu  Ser Ile Asn 
        995                 1000                 1005             


Ala Thr  Asn Ile Lys His Phe  Lys Asn Cys Thr Ser  Ile Ser Gly 
    1010                 1015                 1020             


Asp Leu  His Ile Leu Pro Val  Ala Phe Arg Gly Asp  Ser Phe Thr 
    1025                 1030                 1035             


His Thr  Pro Pro Leu Asp Pro  Gln Glu Leu Asp Ile  Leu Lys Thr 
    1040                 1045                 1050             


Val Lys  Glu Ile Thr Gly Phe  Leu Leu Ile Gln Ala  Trp Pro Glu 
    1055                 1060                 1065             


Asn Arg  Thr Asp Leu His Ala  Phe Glu Asn Leu Glu  Ile Ile Arg 
    1070                 1075                 1080             


Gly Arg  Thr Lys Gln His Gly  Gln Phe Ser Leu Ala  Val Val Ser 
    1085                 1090                 1095             


Leu Asn  Ile Thr Ser Leu Gly  Leu Arg Ser Leu Lys  Glu Ile Ser 
    1100                 1105                 1110             


Asp Gly  Asp Val Ile Ile Ser  Gly Asn Lys Asn Leu  Cys Tyr Ala 
    1115                 1120                 1125             


Asn Thr  Ile Asn Trp Lys Lys  Leu Phe Gly Thr Ser  Gly Gln Lys 
    1130                 1135                 1140             


Thr Lys  Ile Ile Ser Asn Arg  Gly Glu Asn Ser Cys  Lys Ala Thr 
    1145                 1150                 1155             


Gly Gln  Val Cys His Ala Leu  Cys Ser Pro Glu Gly  Cys Trp Gly 
    1160                 1165                 1170             


Pro Glu  Pro Arg Asp Cys Val  Ser Cys Arg Asn Val  Ser Arg Gly 
    1175                 1180                 1185             


Arg Glu  Cys Val Asp Lys Cys  Asn Leu Leu Glu Gly  Glu Pro Arg 
    1190                 1195                 1200             


Glu Phe  Val Glu Asn Ser Glu  Cys Ile Gln Cys His  Pro Glu Cys 
    1205                 1210                 1215             


Leu Pro  Gln Ala Met Asn Ile  Thr Cys Thr Gly Arg  Gly Pro Asp 
    1220                 1225                 1230             


Asn Cys  Ile Gln Cys Ala His  Tyr Ile Asp Gly Pro  His Cys Val 
    1235                 1240                 1245             


Lys Thr  Cys Pro Ala Gly Val  Met Gly Glu Asn Asn  Thr Leu Val 
    1250                 1255                 1260             


Trp Lys  Tyr Ala Asp Ala Gly  His Val Cys His Leu  Cys His Pro 
    1265                 1270                 1275             


Asn Cys  Thr Tyr Gly Cys Thr  Gly Pro Gly Leu Glu  Gly Cys Pro 
    1280                 1285                 1290             


Thr Asn  Gly Pro Lys Ile Pro  Ser Ile Ala Thr Gly  Met Val Gly 
    1295                 1300                 1305             


Ala Leu  Leu Leu Leu Leu Val  Val Ala Leu Gly Ile  Gly Leu Phe 
    1310                 1315                 1320             


Met 
    


<210>  146
<211>  3993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  146
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccctgc cccccttgcc ctatgttctg ggtgctggtg      840

gtggtcggag gcgtgctggc ctgctacagc ctgctggtca ccgtggcctt catcatcttt      900

tgggtgaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      960

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1020

ggatgtgaac tgcgggtgaa gttcagcaga agcgccgacg cccctgccta ccagcagggc     1080

cagaatcagc tgtacaacga gctgaacctg ggcagaaggg aagagtacga cgtcctggat     1140

aagcggagag gccgggaccc tgagatgggc ggcaagcctc ggcggaagaa cccccaggaa     1200

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     1260

aagggcgagc ggaggcgggg caagggccac gacggcctgt atcagggcct gtccaccgcc     1320

accaaggata cctacgacgc cctgcacatg caggccctgc ccccaaggct cgagggcggc     1380

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctaag     1440

cttatgctgc tgctcgtgac cagcctgctg ctgtgcgaac tgccccaccc tgcctttctg     1500

ctgatccccg acatcgtgat gacccagagc cctagcagcc tggccgtgtc cgtgggcgag     1560

aaagtgacca tgagctgcaa gagcagccag agcctgctgt tcagcagcaa ccagaagaac     1620

tacctggcct ggtatcagca gaagcccggc cagagcccca agctgctgat ctactgggcc     1680

agcaccagag aaagcggcgt gcccgataga ttcaccggct ctggcagcgg caccgacttc     1740

accctgacaa tcagcagcgt gaaggccgag gacctggctg tgtactactg ccagcagttc     1800

tacagcttcc cccggacctt tggcggaggc accaagctgg aaatcaagag aggcggcgga     1860

ggaagcggag gcggaggatc tggcggaggg ggctccggag ggggaggctc tgaagtgcag     1920

ctggtggaaa gtggcggcgg actcgtgaag cctggcggct ctctgaagct gagctgtgcc     1980

gccagcggct tcaccttcag cagctacgcc atgtcctggg tgcgccagac ccccgagaag     2040

agactggaat gggtggccac agtgtcctac ggcggcagct acaccttcta ccccgacaat     2100

gtgaagggcc ggttcaccat cagccgggac aacgccaaga acaacctgta cctgcagatg     2160

agccacctga agtccgagga taccgccatg tactattgcg ccagagacta cgactacgat     2220

ttcttcgaca gctggggcca gggcaccacc gtgacagtgt ccagcgagtc taagtacgga     2280

ccgccctgcc ccccttgccc tatgttctgg gtgctggtgg tggtcggagg cgtgctggcc     2340

tgctacagcc tgctggtcac cgtggccttc atcatctttt gggtgaaacg gggcagaaag     2400

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     2460

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgggtgaag     2520

ttcagcagaa gcgccgacgc ccctgcctac cagcagggcc agaatcagct gtacaacgag     2580

ctgaacctgg gcagaaggga agagtacgac gtcctggata agcggagagg ccgggaccct     2640

gagatgggcg gcaagcctcg gcggaagaac ccccaggaag gcctgtataa cgaactgcag     2700

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcggggc     2760

aagggccacg acggcctgta tcagggcctg tccaccgcca ccaaggatac ctacgacgcc     2820

ctgcacatgc aggccctgcc cccaaggctc gagggcggcg gagagggcag aggaagtctt     2880

ctaacatgcg gtgacgtgga ggagaatccc ggccctagga tgcttctcct ggtgacaagc     2940

cttctgctct gtgagttacc acacccagca ttcctcctga tcccacgcaa agtgtgtaac     3000

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     3060

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     3120

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     3180

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     3240

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     3300

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     3360

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     3420

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     3480

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     3540

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     3600

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     3660

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     3720

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     3780

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     3840

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     3900

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     3960

gtggtggccc tggggatcgg cctcttcatg tga                                  3993


<210>  147
<211>  1330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  147

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg 
    450                 455                 460                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Lys 
465                 470                 475                 480 


Leu Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
                485                 490                 495     


Pro Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser 
            500                 505                 510         


Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
        515                 520                 525             


Ser Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
    530                 535                 540                 


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
545                 550                 555                 560 


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
                565                 570                 575     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu 
            580                 585                 590         


Ala Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly 
        595                 600                 605             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys 
                645                 650                 655     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
            660                 665                 670         


Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val 
        675                 680                 685             


Ser Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met 
705                 710                 715                 720 


Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp 
                725                 730                 735     


Tyr Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr 
            740                 745                 750         


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met 
        755                 760                 765             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    770                 775                 780                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
785                 790                 795                 800 


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
                805                 810                 815     


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            820                 825                 830         


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        835                 840                 845             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    850                 855                 860                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
865                 870                 875                 880 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                885                 890                 895     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            900                 905                 910         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        915                 920                 925             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    930                 935                 940                 


Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu 
945                 950                 955                 960 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu 
                965                 970                 975     


Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu 
            980                 985                 990         


Leu Ile Pro Arg Lys Val Cys Asn  Gly Ile Gly Ile Gly  Glu Phe Lys 
        995                 1000                 1005             


Asp Ser  Leu Ser Ile Asn Ala  Thr Asn Ile Lys His  Phe Lys Asn 
    1010                 1015                 1020             


Cys Thr  Ser Ile Ser Gly Asp  Leu His Ile Leu Pro  Val Ala Phe 
    1025                 1030                 1035             


Arg Gly  Asp Ser Phe Thr His  Thr Pro Pro Leu Asp  Pro Gln Glu 
    1040                 1045                 1050             


Leu Asp  Ile Leu Lys Thr Val  Lys Glu Ile Thr Gly  Phe Leu Leu 
    1055                 1060                 1065             


Ile Gln  Ala Trp Pro Glu Asn  Arg Thr Asp Leu His  Ala Phe Glu 
    1070                 1075                 1080             


Asn Leu  Glu Ile Ile Arg Gly  Arg Thr Lys Gln His  Gly Gln Phe 
    1085                 1090                 1095             


Ser Leu  Ala Val Val Ser Leu  Asn Ile Thr Ser Leu  Gly Leu Arg 
    1100                 1105                 1110             


Ser Leu  Lys Glu Ile Ser Asp  Gly Asp Val Ile Ile  Ser Gly Asn 
    1115                 1120                 1125             


Lys Asn  Leu Cys Tyr Ala Asn  Thr Ile Asn Trp Lys  Lys Leu Phe 
    1130                 1135                 1140             


Gly Thr  Ser Gly Gln Lys Thr  Lys Ile Ile Ser Asn  Arg Gly Glu 
    1145                 1150                 1155             


Asn Ser  Cys Lys Ala Thr Gly  Gln Val Cys His Ala  Leu Cys Ser 
    1160                 1165                 1170             


Pro Glu  Gly Cys Trp Gly Pro  Glu Pro Arg Asp Cys  Val Ser Cys 
    1175                 1180                 1185             


Arg Asn  Val Ser Arg Gly Arg  Glu Cys Val Asp Lys  Cys Asn Leu 
    1190                 1195                 1200             


Leu Glu  Gly Glu Pro Arg Glu  Phe Val Glu Asn Ser  Glu Cys Ile 
    1205                 1210                 1215             


Gln Cys  His Pro Glu Cys Leu  Pro Gln Ala Met Asn  Ile Thr Cys 
    1220                 1225                 1230             


Thr Gly  Arg Gly Pro Asp Asn  Cys Ile Gln Cys Ala  His Tyr Ile 
    1235                 1240                 1245             


Asp Gly  Pro His Cys Val Lys  Thr Cys Pro Ala Gly  Val Met Gly 
    1250                 1255                 1260             


Glu Asn  Asn Thr Leu Val Trp  Lys Tyr Ala Asp Ala  Gly His Val 
    1265                 1270                 1275             


Cys His  Leu Cys His Pro Asn  Cys Thr Tyr Gly Cys  Thr Gly Pro 
    1280                 1285                 1290             


Gly Leu  Glu Gly Cys Pro Thr  Asn Gly Pro Lys Ile  Pro Ser Ile 
    1295                 1300                 1305             


Ala Thr  Gly Met Val Gly Ala  Leu Leu Leu Leu Leu  Val Val Ala 
    1310                 1315                 1320             


Leu Gly  Ile Gly Leu Phe Met  
    1325                 1330 


<210>  148
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  148
ccctgccccc cttgccctat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc       60

tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa      120

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      180

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc      240

agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg      300

aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag      360

atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa      420

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag      480

ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg      540

cacatgcagg ccctgccccc aaggctcgag ggcggcggag agggcagagg aagtcttcta      600

acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt      660

ctgctctgtg agttaccaca cccagcattc ctcctgatcc cacgcaaagt gtgtaacgga      720

ataggtattg gtgaatttaa agactcactc tccataaatg ctacgaatat taaacacttc      780

aaaaactgca cctccatcag tggcgatctc cacatcctgc cggtggcatt taggggtgac      840

tccttcacac atactcctcc tctggatcca caggaactgg atattctgaa aaccgtaaag      900

gaaatcacag ggtttttgct gattcaggct tggcctgaaa acaggacgga cctccatgcc      960

tttgagaacc tagaaatcat acgcggcagg accaagcaac atggtcagtt ttctcttgca     1020

gtcgtcagcc tgaacataac atccttggga ttacgctccc tcaaggagat aagtgatgga     1080

gatgtgataa tttcaggaaa caaaaatttg tgctatgcaa atacaataaa ctggaaaaaa     1140

ctgtttggga cctccggtca gaaaaccaaa attataagca acagaggtga aaacagctgc     1200

aaggccacag gccaggtctg ccatgccttg tgctcccccg agggctgctg gggcccggag     1260

cccagggact gcgtctcttg ccggaatgtc agccgaggca gggaatgcgt ggacaagtgc     1320

aaccttctgg agggtgagcc aagggagttt gtggagaact ctgagtgcat acagtgccac     1380

ccagagtgcc tgcctcaggc catgaacatc acctgcacag gacggggacc agacaactgt     1440

atccagtgtg cccactacat tgacggcccc cactgcgtca agacctgccc ggcaggagtc     1500

atgggagaaa acaacaccct ggtctggaag tacgcagacg ccggccatgt gtgccacctg     1560

tgccatccaa actgcaccta cggatgcact gggccaggtc ttgaaggctg tccaacgaat     1620

gggcctaaga tcccgtccat cgccactggg atggtggggg ccctcctctt gctgctggtg     1680

gtggccctgg ggatcggcct cttcatgtga                                      1710


<210>  149
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  149

Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
1               5                   10                  15      


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            20                  25                  30          


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        35                  40                  45              


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    50                  55                  60                  


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly 
            180                 185                 190         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        195                 200                 205             


Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
    210                 215                 220                 


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
225                 230                 235                 240 


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
                245                 250                 255     


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
            260                 265                 270         


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
        275                 280                 285             


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
    290                 295                 300                 


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
305                 310                 315                 320 


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
                325                 330                 335     


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
            340                 345                 350         


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
        355                 360                 365             


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
    370                 375                 380                 


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
385                 390                 395                 400 


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
                405                 410                 415     


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
            420                 425                 430         


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
        435                 440                 445             


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
    450                 455                 460                 


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
465                 470                 475                 480 


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
                485                 490                 495     


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
            500                 505                 510         


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
        515                 520                 525             


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile 
    530                 535                 540                 


Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val 
545                 550                 555                 560 


Val Ala Leu Gly Ile Gly Leu Phe Met 
                565                 


<210>  150
<211>  2550
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  150
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcgagtctaa gtacggaccg      840

ccctgccccc cttgccctat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc      900

tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa      960

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1020

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc     1080

agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg     1140

aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag     1200

atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1260

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag     1320

ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg     1380

cacatgcagg ccctgccccc aaggctcgag ggcggcggag agggcagagg aagtcttcta     1440

acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt     1500

ctgctctgtg agttaccaca cccagcattc ctcctgatcc cacgcaaagt gtgtaacgga     1560

ataggtattg gtgaatttaa agactcactc tccataaatg ctacgaatat taaacacttc     1620

aaaaactgca cctccatcag tggcgatctc cacatcctgc cggtggcatt taggggtgac     1680

tccttcacac atactcctcc tctggatcca caggaactgg atattctgaa aaccgtaaag     1740

gaaatcacag ggtttttgct gattcaggct tggcctgaaa acaggacgga cctccatgcc     1800

tttgagaacc tagaaatcat acgcggcagg accaagcaac atggtcagtt ttctcttgca     1860

gtcgtcagcc tgaacataac atccttggga ttacgctccc tcaaggagat aagtgatgga     1920

gatgtgataa tttcaggaaa caaaaatttg tgctatgcaa atacaataaa ctggaaaaaa     1980

ctgtttggga cctccggtca gaaaaccaaa attataagca acagaggtga aaacagctgc     2040

aaggccacag gccaggtctg ccatgccttg tgctcccccg agggctgctg gggcccggag     2100

cccagggact gcgtctcttg ccggaatgtc agccgaggca gggaatgcgt ggacaagtgc     2160

aaccttctgg agggtgagcc aagggagttt gtggagaact ctgagtgcat acagtgccac     2220

ccagagtgcc tgcctcaggc catgaacatc acctgcacag gacggggacc agacaactgt     2280

atccagtgtg cccactacat tgacggcccc cactgcgtca agacctgccc ggcaggagtc     2340

atgggagaaa acaacaccct ggtctggaag tacgcagacg ccggccatgt gtgccacctg     2400

tgccatccaa actgcaccta cggatgcact gggccaggtc ttgaaggctg tccaacgaat     2460

gggcctaaga tcccgtccat cgccactggg atggtggggg ccctcctctt gctgctggtg     2520

gtggccctgg ggatcggcct cttcatgtga                                      2550


<210>  151
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  151

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                325                 330                 335     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            340                 345                 350         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu 
465                 470                 475                 480 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu 
                485                 490                 495     


Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu 
            500                 505                 510         


Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
        515                 520                 525             


Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
    530                 535                 540                 


Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
545                 550                 555                 560 


Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
                565                 570                 575     


Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
            580                 585                 590         


Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
        595                 600                 605             


Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
    610                 615                 620                 


Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
625                 630                 635                 640 


Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
                645                 650                 655     


Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
            660                 665                 670         


Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
        675                 680                 685             


Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
    690                 695                 700                 


Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
705                 710                 715                 720 


Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
                725                 730                 735     


Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
            740                 745                 750         


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
        755                 760                 765             


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
    770                 775                 780                 


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
785                 790                 795                 800 


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
                805                 810                 815     


Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
            820                 825                 830         


Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
        835                 840                 845             


Met 
    


<210>  152
<211>  2769
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  152
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcgagtctaa gtacggaccg      840

ccctgccccc cttgccctgg ccagcctaga gaaccccagg tgtacaccct gcctcccagc      900

caggaagaga tgaccaagaa ccaggtgtcc ctgacctgcc tggtcaaagg cttctacccc      960

agcgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1020

ccccctgtgc tggacagcga cggcagcttc ttcctgtact cccggctgac cgtggacaag     1080

agccggtggc aggaaggcaa cgtcttcagc tgcagcgtga tgcacgaggc cctgcacaac     1140

cactacaccc agaagtccct gagcctgagc ctgggcaaga tgttctgggt gctggtggtg     1200

gtcggaggcg tgctggcctg ctacagcctg ctggtcaccg tggccttcat catcttttgg     1260

gtgaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     1320

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1380

tgtgaactgc gggtgaagtt cagcagaagc gccgacgccc ctgcctacca gcagggccag     1440

aatcagctgt acaacgagct gaacctgggc agaagggaag agtacgacgt cctggataag     1500

cggagaggcc gggaccctga gatgggcggc aagcctcggc ggaagaaccc ccaggaaggc     1560

ctgtataacg aactgcagaa agacaagatg gccgaggcct acagcgagat cggcatgaag     1620

ggcgagcgga ggcggggcaa gggccacgac ggcctgtatc agggcctgtc caccgccacc     1680

aaggatacct acgacgccct gcacatgcag gccctgcccc caaggctcga gggcggcgga     1740

gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatccagg ccctaggatg     1800

ccacctccaa gactcctctt cttcctcctc ttcctgacac caatggaagt caggcctgag     1860

gaacctctag tggtgaaggt ggaagaggga gataacgctg tgttacagtg cctcaaggga     1920

acctcagatg gacccactca gcagctgacc tggtctcggg agtctccgct taaacccttc     1980

ctgaaactca gccttggact gccaggtctg ggaatccaca tgaggccact ggctatctgg     2040

ctgttcatct tcaacgtctc tcaacagatg ggaggcttct acctgtgtca gcctggacca     2100

ccttctgaga aggcatggca gcctggttgg acagtcaatg tggagggttc tggtgagctg     2160

ttccggtgga atgtttcgga cctaggtgga ctgggatgtg gtctgaagaa caggtcctca     2220

gagggaccta gctctccttc cgggaagctc atgagcccca agctgtatgt gtgggccaaa     2280

gaccgccctg agatctggga gggagagcct ccgtgtgtcc caccgaggga cagcctgaac     2340

cagagcctca gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg     2400

gtaccccctg actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg     2460

cctaagtcat tgctgagcct agagctgaag gacgatcgcc ctgccagaga tatgtgggta     2520

atggagacgg gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt     2580

caccgtggca acctgaccat gtcattccac ctggagatca ctgctcggcc agtactatgg     2640

cactggctgc tgaggactgg tggctggaag gtctcagctg tgactttggc ttatctgatc     2700

ttctgcctgt gttcccttgt gggcattctt catcttcaaa gagccctggt cctgaggagg     2760

aaaagatga                                                             2769


<210>  153
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  153

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln 
        275                 280                 285             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    290                 295                 300                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
305                 310                 315                 320 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                325                 330                 335     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            340                 345                 350         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        355                 360                 365             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    370                 375                 380                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val 
385                 390                 395                 400 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                405                 410                 415     


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            420                 425                 430         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        435                 440                 445             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    450                 455                 460                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
465                 470                 475                 480 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                485                 490                 495     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            500                 505                 510         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        515                 520                 525             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    530                 535                 540                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
545                 550                 555                 560 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu 
                565                 570                 575     


Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
            580                 585                 590         


Glu Glu Asn Pro Gly Pro Arg Met Pro Pro Pro Arg Leu Leu Phe Phe 
        595                 600                 605             


Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val 
    610                 615                 620                 


Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly 
625                 630                 635                 640 


Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro 
                645                 650                 655     


Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile 
            660                 665                 670         


His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln 
        675                 680                 685             


Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys 
    690                 695                 700                 


Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu 
705                 710                 715                 720 


Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys 
                725                 730                 735     


Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser 
            740                 745                 750         


Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly 
        755                 760                 765             


Glu Pro Pro Cys Val Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser 
    770                 775                 780                 


Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly 
785                 790                 795                 800 


Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val 
                805                 810                 815     


His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp 
            820                 825                 830         


Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro 
        835                 840                 845             


Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn 
    850                 855                 860                 


Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp 
865                 870                 875                 880 


His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu 
                885                 890                 895     


Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu 
            900                 905                 910         


Gln Arg Ala Leu Val Leu Arg Arg Lys Arg 
        915                 920         


<210>  154
<211>  2871
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  154
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcgagtctaa gtacggaccg      840

ccctgccccc cttgccctgg ccagcctaga gaaccccagg tgtacaccct gcctcccagc      900

caggaagaga tgaccaagaa ccaggtgtcc ctgacctgcc tggtcaaagg cttctacccc      960

agcgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1020

ccccctgtgc tggacagcga cggcagcttc ttcctgtact cccggctgac cgtggacaag     1080

agccggtggc aggaaggcaa cgtcttcagc tgcagcgtga tgcacgaggc cctgcacaac     1140

cactacaccc agaagtccct gagcctgagc ctgggcaaga tgttctgggt gctggtggtg     1200

gtcggaggcg tgctggcctg ctacagcctg ctggtcaccg tggccttcat catcttttgg     1260

gtgaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     1320

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1380

tgtgaactgc gggtgaagtt cagcagaagc gccgacgccc ctgcctacca gcagggccag     1440

aatcagctgt acaacgagct gaacctgggc agaagggaag agtacgacgt cctggataag     1500

cggagaggcc gggaccctga gatgggcggc aagcctcggc ggaagaaccc ccaggaaggc     1560

ctgtataacg aactgcagaa agacaagatg gccgaggcct acagcgagat cggcatgaag     1620

ggcgagcgga ggcggggcaa gggccacgac ggcctgtatc agggcctgtc caccgccacc     1680

aaggatacct acgacgccct gcacatgcag gccctgcccc caaggctcga gggcggcgga     1740

gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctaggatg     1800

cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt cctcctgatc     1860

ccacgcaaag tgtgtaacgg aataggtatt ggtgaattta aagactcact ctccataaat     1920

gctacgaata ttaaacactt caaaaactgc acctccatca gtggcgatct ccacatcctg     1980

ccggtggcat ttaggggtga ctccttcaca catactcctc ctctggatcc acaggaactg     2040

gatattctga aaaccgtaaa ggaaatcaca gggtttttgc tgattcaggc ttggcctgaa     2100

aacaggacgg acctccatgc ctttgagaac ctagaaatca tacgcggcag gaccaagcaa     2160

catggtcagt tttctcttgc agtcgtcagc ctgaacataa catccttggg attacgctcc     2220

ctcaaggaga taagtgatgg agatgtgata atttcaggaa acaaaaattt gtgctatgca     2280

aatacaataa actggaaaaa actgtttggg acctccggtc agaaaaccaa aattataagc     2340

aacagaggtg aaaacagctg caaggccaca ggccaggtct gccatgcctt gtgctccccc     2400

gagggctgct ggggcccgga gcccagggac tgcgtctctt gccggaatgt cagccgaggc     2460

agggaatgcg tggacaagtg caaccttctg gagggtgagc caagggagtt tgtggagaac     2520

tctgagtgca tacagtgcca cccagagtgc ctgcctcagg ccatgaacat cacctgcaca     2580

ggacggggac cagacaactg tatccagtgt gcccactaca ttgacggccc ccactgcgtc     2640

aagacctgcc cggcaggagt catgggagaa aacaacaccc tggtctggaa gtacgcagac     2700

gccggccatg tgtgccacct gtgccatcca aactgcacct acggatgcac tgggccaggt     2760

cttgaaggct gtccaacgaa tgggcctaag atcccgtcca tcgccactgg gatggtgggg     2820

gccctcctct tgctgctggt ggtggccctg gggatcggcc tcttcatgtg a              2871


<210>  155
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  155

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln 
        275                 280                 285             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    290                 295                 300                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
305                 310                 315                 320 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                325                 330                 335     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            340                 345                 350         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        355                 360                 365             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    370                 375                 380                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val 
385                 390                 395                 400 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                405                 410                 415     


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            420                 425                 430         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        435                 440                 445             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    450                 455                 460                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
465                 470                 475                 480 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                485                 490                 495     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            500                 505                 510         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        515                 520                 525             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    530                 535                 540                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
545                 550                 555                 560 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu 
                565                 570                 575     


Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
            580                 585                 590         


Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu 
        595                 600                 605             


Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val 
    610                 615                 620                 


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
625                 630                 635                 640 


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
                645                 650                 655     


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
            660                 665                 670         


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
        675                 680                 685             


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
    690                 695                 700                 


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
705                 710                 715                 720 


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
                725                 730                 735     


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
            740                 745                 750         


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
        755                 760                 765             


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
    770                 775                 780                 


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
785                 790                 795                 800 


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
                805                 810                 815     


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
            820                 825                 830         


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
        835                 840                 845             


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
    850                 855                 860                 


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
865                 870                 875                 880 


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
                885                 890                 895     


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
            900                 905                 910         


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
        915                 920                 925             


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
    930                 935                 940                 


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
945                 950                 955     


<210>  156
<211>  3198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  156
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcgagtctaa gtacggaccg      840

ccttgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccacca      900

aaacccaagg acaccctgat gatcagccgg acccccgagg tgacctgcgt ggtggtggac      960

gtgagccagg aagatcccga ggtccagttc aattggtacg tggacggcgt ggaagtgcac     1020

aacgccaaga ccaagcccag agaggaacag ttccaaagca cctaccgggt ggtgtctgtg     1080

ctgaccgtgc tgcaccagga ctggctgaac ggcaaagaat acaagtgcaa ggtgtccaac     1140

aagggcctgc ccagcagcat cgaaaagacc atcagcaagg ccaagggcca gcctcgcgag     1200

ccccaggtgt acaccctgcc tccctcccag gaagagatga ccaagaacca ggtgtccctg     1260

acctgcctgg tgaagggctt ctaccccagc gacatcgccg tggagtggga gagcaacggc     1320

cagcctgaga acaactacaa gaccacccct cccgtgctgg acagcgacgg cagcttcttc     1380

ctgtacagcc ggctgaccgt ggacaagagc cggtggcagg aaggcaacgt ctttagctgc     1440

agcgtgatgc acgaggccct gcacaaccac tacacccaga agagcctgag cctgtccctg     1500

ggcaagatgt tctgggtgct ggtggtggtg ggcggggtgc tggcctgcta cagcctgctg     1560

gtgacagtgg ccttcatcat cttttgggtg aaacggggca gaaagaaact cctgtatata     1620

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1680

cgatttccag aagaagaaga aggaggatgt gaactgcggg tgaagttcag cagaagcgcc     1740

gacgcccctg cctaccagca gggccagaat cagctgtaca acgagctgaa cctgggcaga     1800

agggaagagt acgacgtcct ggataagcgg agaggccggg accctgagat gggcggcaag     1860

cctcggcgga agaaccccca ggaaggcctg tataacgaac tgcagaaaga caagatggcc     1920

gaggcctaca gcgagatcgg catgaagggc gagcggaggc ggggcaaggg ccacgacggc     1980

ctgtatcagg gcctgtccac cgccaccaag gatacctacg acgccctgca catgcaggcc     2040

ctgcccccaa ggctcgaggg cggcggagag ggcagaggaa gtcttctaac atgcggtgac     2100

gtggaggaga atcccggccc taggatgctt ctcctggtga caagccttct gctctgtgag     2160

ttaccacacc cagcattcct cctgatccca cgcaaagtgt gtaacggaat aggtattggt     2220

gaatttaaag actcactctc cataaatgct acgaatatta aacacttcaa aaactgcacc     2280

tccatcagtg gcgatctcca catcctgccg gtggcattta ggggtgactc cttcacacat     2340

actcctcctc tggatccaca ggaactggat attctgaaaa ccgtaaagga aatcacaggg     2400

tttttgctga ttcaggcttg gcctgaaaac aggacggacc tccatgcctt tgagaaccta     2460

gaaatcatac gcggcaggac caagcaacat ggtcagtttt ctcttgcagt cgtcagcctg     2520

aacataacat ccttgggatt acgctccctc aaggagataa gtgatggaga tgtgataatt     2580

tcaggaaaca aaaatttgtg ctatgcaaat acaataaact ggaaaaaact gtttgggacc     2640

tccggtcaga aaaccaaaat tataagcaac agaggtgaaa acagctgcaa ggccacaggc     2700

caggtctgcc atgccttgtg ctcccccgag ggctgctggg gcccggagcc cagggactgc     2760

gtctcttgcc ggaatgtcag ccgaggcagg gaatgcgtgg acaagtgcaa ccttctggag     2820

ggtgagccaa gggagtttgt ggagaactct gagtgcatac agtgccaccc agagtgcctg     2880

cctcaggcca tgaacatcac ctgcacagga cggggaccag acaactgtat ccagtgtgcc     2940

cactacattg acggccccca ctgcgtcaag acctgcccgg caggagtcat gggagaaaac     3000

aacaccctgg tctggaagta cgcagacgcc ggccatgtgt gccacctgtg ccatccaaac     3060

tgcacctacg gatgcactgg gccaggtctt gaaggctgtc caacgaatgg gcctaagatc     3120

ccgtccatcg ccactgggat ggtgggggcc ctcctcttgc tgctggtggt ggccctgggg     3180

atcggcctct tcatgtga                                                   3198


<210>  157
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  157

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    370                 375                 380                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly 
            500                 505                 510         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        515                 520                 525             


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    530                 535                 540                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
545                 550                 555                 560 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                565                 570                 575     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            580                 585                 590         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        595                 600                 605             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    610                 615                 620                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
625                 630                 635                 640 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                645                 650                 655     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            660                 665                 670         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly 
        675                 680                 685             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    690                 695                 700                 


Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
705                 710                 715                 720 


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
                725                 730                 735     


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
            740                 745                 750         


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
        755                 760                 765             


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
    770                 775                 780                 


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
785                 790                 795                 800 


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
                805                 810                 815     


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
            820                 825                 830         


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
        835                 840                 845             


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
    850                 855                 860                 


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
865                 870                 875                 880 


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
                885                 890                 895     


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
            900                 905                 910         


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
        915                 920                 925             


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
    930                 935                 940                 


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
945                 950                 955                 960 


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
                965                 970                 975     


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
            980                 985                 990         


Pro Ala Gly Val Met Gly Glu Asn  Asn Thr Leu Val Trp  Lys Tyr Ala 
        995                 1000                 1005             


Asp Ala  Gly His Val Cys His  Leu Cys His Pro Asn  Cys Thr Tyr 
    1010                 1015                 1020             


Gly Cys  Thr Gly Pro Gly Leu  Glu Gly Cys Pro Thr  Asn Gly Pro 
    1025                 1030                 1035             


Lys Ile  Pro Ser Ile Ala Thr  Gly Met Val Gly Ala  Leu Leu Leu 
    1040                 1045                 1050             


Leu Leu  Val Val Ala Leu Gly  Ile Gly Leu Phe Met  
    1055                 1060                 1065 


<210>  158
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  158
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccctgc cccccttgcc ctatgttctg ggtgctggtg      840

gtggtcggag gcgtgctggc ctgctacagc ctgctggtca ccgtggcctt catcatcttt      900

tgggtgaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      960

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1020

ggatgtgaac tgcgggtgaa gttcagcaga agcgccgacg cccctgccta ccagcagggc     1080

cagaatcagc tgtacaacga gctgaacctg ggcagaaggg aagagtacga cgtcctggat     1140

aagcggagag gccgggaccc tgagatgggc ggcaagcctc ggcggaagaa cccccaggaa     1200

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     1260

aagggcgagc ggaggcgggg caagggccac gacggcctgt atcagggcct gtccaccgcc     1320

accaaggata cctacgacgc cctgcacatg caggccctgc ccccaaggct cgagggcggc     1380

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc aggccctagg     1440

atgccacctc caagactcct cttcttcctc ctcttcctga caccaatgga agtcaggcct     1500

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgttaca gtgcctcaag     1560

ggaacctcag atggacccac tcagcagctg acctggtctc gggagtctcc gcttaaaccc     1620

ttcctgaaac tcagccttgg actgccaggt ctgggaatcc acatgaggcc actggctatc     1680

tggctgttca tcttcaacgt ctctcaacag atgggaggct tctacctgtg tcagcctgga     1740

ccaccttctg agaaggcatg gcagcctggt tggacagtca atgtggaggg ttctggtgag     1800

ctgttccggt ggaatgtttc ggacctaggt ggactgggat gtggtctgaa gaacaggtcc     1860

tcagagggac ctagctctcc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc     1920

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg     1980

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt     2040

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag     2100

gggcctaagt cattgctgag cctagagctg aaggacgatc gccctgccag agatatgtgg     2160

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat     2220

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta     2280

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg     2340

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg     2400

aggaaaagat ga                                                         2412


<210>  159
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  159

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg 
    450                 455                 460                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
465                 470                 475                 480 


Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
                485                 490                 495     


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            500                 505                 510         


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        515                 520                 525             


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    530                 535                 540                 


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
545                 550                 555                 560 


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                565                 570                 575     


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            580                 585                 590         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        595                 600                 605             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    610                 615                 620                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
625                 630                 635                 640 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                645                 650                 655     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            660                 665                 670         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        675                 680                 685             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    690                 695                 700                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
705                 710                 715                 720 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                725                 730                 735     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            740                 745                 750         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        755                 760                 765             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    770                 775                 780                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
785                 790                 795                 800 


Arg Lys Arg 
            


<210>  160
<211>  2514
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  160
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccctgc cccccttgcc ctatgttctg ggtgctggtg      840

gtggtcggag gcgtgctggc ctgctacagc ctgctggtca ccgtggcctt catcatcttt      900

tgggtgaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      960

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1020

ggatgtgaac tgcgggtgaa gttcagcaga agcgccgacg cccctgccta ccagcagggc     1080

cagaatcagc tgtacaacga gctgaacctg ggcagaaggg aagagtacga cgtcctggat     1140

aagcggagag gccgggaccc tgagatgggc ggcaagcctc ggcggaagaa cccccaggaa     1200

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     1260

aagggcgagc ggaggcgggg caagggccac gacggcctgt atcagggcct gtccaccgcc     1320

accaaggata cctacgacgc cctgcacatg caggccctgc ccccaaggct cgagggcggc     1380

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctagg     1440

atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg     1500

atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata     1560

aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc     1620

ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa     1680

ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct     1740

gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag     1800

caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc     1860

tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat     1920

gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata     1980

agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc     2040

cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga     2100

ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag     2160

aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc     2220

acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc     2280

gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca     2340

gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca     2400

ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg     2460

ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga           2514


<210>  161
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  161

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg 
    450                 455                 460                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
465                 470                 475                 480 


Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
                485                 490                 495     


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            500                 505                 510         


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        515                 520                 525             


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    530                 535                 540                 


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
545                 550                 555                 560 


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                565                 570                 575     


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            580                 585                 590         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        595                 600                 605             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    610                 615                 620                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
625                 630                 635                 640 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                645                 650                 655     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            660                 665                 670         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        675                 680                 685             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    690                 695                 700                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
705                 710                 715                 720 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                725                 730                 735     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            740                 745                 750         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        755                 760                 765             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    770                 775                 780                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
785                 790                 795                 800 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                805                 810                 815     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            820                 825                 830         


Ile Gly Leu Phe Met 
        835         


<210>  162
<211>  2733
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  162
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccctgc cccccttgcc ctggccagcc tagagaaccc      840

caggtgtaca ccctgcctcc cagccaggaa gagatgacca agaaccaggt gtccctgacc      900

tgcctggtca aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag      960

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggcag cttcttcctg     1020

tactcccggc tgaccgtgga caagagccgg tggcaggaag gcaacgtctt cagctgcagc     1080

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagcctgggc     1140

aagatgttct gggtgctggt ggtggtcgga ggcgtgctgg cctgctacag cctgctggtc     1200

accgtggcct tcatcatctt ttgggtgaaa cggggcagaa agaaactcct gtatatattc     1260

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1320

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac     1380

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg     1440

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct     1500

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     1560

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg     1620

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg     1680

cccccaaggc tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg     1740

gaggagaatc caggccctag gatgccacct ccaagactcc tcttcttcct cctcttcctg     1800

acaccaatgg aagtcaggcc tgaggaacct ctagtggtga aggtggaaga gggagataac     1860

gctgtgttac agtgcctcaa gggaacctca gatggaccca ctcagcagct gacctggtct     1920

cgggagtctc cgcttaaacc cttcctgaaa ctcagccttg gactgccagg tctgggaatc     1980

cacatgaggc cactggctat ctggctgttc atcttcaacg tctctcaaca gatgggaggc     2040

ttctacctgt gtcagcctgg accaccttct gagaaggcat ggcagcctgg ttggacagtc     2100

aatgtggagg gttctggtga gctgttccgg tggaatgttt cggacctagg tggactggga     2160

tgtggtctga agaacaggtc ctcagaggga cctagctctc cttccgggaa gctcatgagc     2220

cccaagctgt atgtgtgggc caaagaccgc cctgagatct gggagggaga gcctccgtgt     2280

gtcccaccga gggacagcct gaaccagagc ctcagccagg acctcaccat ggcccctggc     2340

tccacactct ggctgtcctg tggggtaccc cctgactctg tgtccagggg ccccctctcc     2400

tggacccatg tgcaccccaa ggggcctaag tcattgctga gcctagagct gaaggacgat     2460

cgccctgcca gagatatgtg ggtaatggag acgggtctgt tgttgccccg ggccacagct     2520

caagacgctg gaaagtatta ttgtcaccgt ggcaacctga ccatgtcatt ccacctggag     2580

atcactgctc ggccagtact atggcactgg ctgctgagga ctggtggctg gaaggtctca     2640

gctgtgactt tggcttatct gatcttctgc ctgtgttccc ttgtgggcat tcttcatctt     2700

caaagagccc tggtcctgag gaggaaaaga tga                                  2733


<210>  163
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  163

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp 
    370                 375                 380                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
385                 390                 395                 400 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
                405                 410                 415     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            420                 425                 430         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        435                 440                 445             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    450                 455                 460                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
465                 470                 475                 480 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                485                 490                 495     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            500                 505                 510         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        515                 520                 525             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    530                 535                 540                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
545                 550                 555                 560 


Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Pro Pro Pro Arg 
            580                 585                 590         


Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu 
        595                 600                 605             


Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln 
    610                 615                 620                 


Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser 
625                 630                 635                 640 


Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro 
                645                 650                 655     


Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe 
            660                 665                 670         


Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro 
        675                 680                 685             


Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly 
    690                 695                 700                 


Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly 
705                 710                 715                 720 


Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly 
                725                 730                 735     


Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu 
            740                 745                 750         


Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro Arg Asp Ser Leu Asn 
        755                 760                 765             


Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp 
    770                 775                 780                 


Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser 
785                 790                 795                 800 


Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu 
                805                 810                 815     


Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly 
            820                 825                 830         


Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys 
        835                 840                 845             


His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg 
    850                 855                 860                 


Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser 
865                 870                 875                 880 


Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly 
                885                 890                 895     


Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg 
            900                 905                 910 


<210>  164
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  164
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccctgc cccccttgcc ctggccagcc tagagaaccc      840

caggtgtaca ccctgcctcc cagccaggaa gagatgacca agaaccaggt gtccctgacc      900

tgcctggtca aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag      960

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggcag cttcttcctg     1020

tactcccggc tgaccgtgga caagagccgg tggcaggaag gcaacgtctt cagctgcagc     1080

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagcctgggc     1140

aagatgttct gggtgctggt ggtggtcgga ggcgtgctgg cctgctacag cctgctggtc     1200

accgtggcct tcatcatctt ttgggtgaaa cggggcagaa agaaactcct gtatatattc     1260

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1320

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac     1380

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg     1440

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct     1500

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     1560

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg     1620

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg     1680

cccccaaggc tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg     1740

gaggagaatc ccggccctag gatgcttctc ctggtgacaa gccttctgct ctgtgagtta     1800

ccacacccag cattcctcct gatcccacgc aaagtgtgta acggaatagg tattggtgaa     1860

tttaaagact cactctccat aaatgctacg aatattaaac acttcaaaaa ctgcacctcc     1920

atcagtggcg atctccacat cctgccggtg gcatttaggg gtgactcctt cacacatact     1980

cctcctctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     2040

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcctttga gaacctagaa     2100

atcatacgcg gcaggaccaa gcaacatggt cagttttctc ttgcagtcgt cagcctgaac     2160

ataacatcct tgggattacg ctccctcaag gagataagtg atggagatgt gataatttca     2220

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     2280

ggtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacaggccag     2340

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagcccag ggactgcgtc     2400

tcttgccgga atgtcagccg aggcagggaa tgcgtggaca agtgcaacct tctggagggt     2460

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga gtgcctgcct     2520

caggccatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     2580

tacattgacg gcccccactg cgtcaagacc tgcccggcag gagtcatggg agaaaacaac     2640

accctggtct ggaagtacgc agacgccggc catgtgtgcc acctgtgcca tccaaactgc     2700

acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc taagatcccg     2760

tccatcgcca ctgggatggt gggggccctc ctcttgctgc tggtggtggc cctggggatc     2820

ggcctcttca tgtga                                                      2835


<210>  165
<211>  944
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  165

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp 
    370                 375                 380                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
385                 390                 395                 400 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
                405                 410                 415     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            420                 425                 430         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        435                 440                 445             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    450                 455                 460                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
465                 470                 475                 480 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                485                 490                 495     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            500                 505                 510         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        515                 520                 525             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    530                 535                 540                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
545                 550                 555                 560 


Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val 
            580                 585                 590         


Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile 
        595                 600                 605             


Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
    610                 615                 620                 


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
625                 630                 635                 640 


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
                645                 650                 655     


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
            660                 665                 670         


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
        675                 680                 685             


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
    690                 695                 700                 


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
705                 710                 715                 720 


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
                725                 730                 735     


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
            740                 745                 750         


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
        755                 760                 765             


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
    770                 775                 780                 


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
785                 790                 795                 800 


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
                805                 810                 815     


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
            820                 825                 830         


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
        835                 840                 845             


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
    850                 855                 860                 


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
865                 870                 875                 880 


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
                885                 890                 895     


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
            900                 905                 910         


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
        915                 920                 925             


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
    930                 935                 940                 


<210>  166
<211>  3060
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  166
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccttgc ccaccgtgcc cagcaccacc tgtggcagga      840

ccgtcagtct tcctcttccc accaaaaccc aaggacaccc tgatgatcag ccggaccccc      900

gaggtgacct gcgtggtggt ggacgtgagc caggaagatc ccgaggtcca gttcaattgg      960

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagttccaa     1020

agcacctacc gggtggtgtc tgtgctgacc gtgctgcacc aggactggct gaacggcaaa     1080

gaatacaagt gcaaggtgtc caacaagggc ctgcccagca gcatcgaaaa gaccatcagc     1140

aaggccaagg gccagcctcg cgagccccag gtgtacaccc tgcctccctc ccaggaagag     1200

atgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     1260

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1320

ctggacagcg acggcagctt cttcctgtac agccggctga ccgtggacaa gagccggtgg     1380

caggaaggca acgtctttag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1440

cagaagagcc tgagcctgtc cctgggcaag atgttctggg tgctggtggt ggtgggcggg     1500

gtgctggcct gctacagcct gctggtgaca gtggccttca tcatcttttg ggtgaaacgg     1560

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1620

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1680

cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg     1740

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc     1800

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac     1860

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg     1920

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc     1980

tacgacgccc tgcacatgca ggccctgccc ccaaggctcg agggcggcgg agagggcaga     2040

ggaagtcttc taacatgcgg tgacgtggag gagaatccag gccctaggat gccacctcca     2100

agactcctct tcttcctcct cttcctgaca ccaatggaag tcaggcctga ggaacctcta     2160

gtggtgaagg tggaagaggg agataacgct gtgttacagt gcctcaaggg aacctcagat     2220

ggacccactc agcagctgac ctggtctcgg gagtctccgc ttaaaccctt cctgaaactc     2280

agccttggac tgccaggtct gggaatccac atgaggccac tggctatctg gctgttcatc     2340

ttcaacgtct ctcaacagat gggaggcttc tacctgtgtc agcctggacc accttctgag     2400

aaggcatggc agcctggttg gacagtcaat gtggagggtt ctggtgagct gttccggtgg     2460

aatgtttcgg acctaggtgg actgggatgt ggtctgaaga acaggtcctc agagggacct     2520

agctctcctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     2580

gagatctggg agggagagcc tccgtgtgtc ccaccgaggg acagcctgaa ccagagcctc     2640

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2700

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2760

ttgctgagcc tagagctgaa ggacgatcgc cctgccagag atatgtgggt aatggagacg     2820

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2880

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2940

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     3000

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagatga     3060


<210>  167
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  167

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
385                 390                 395                 400 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val 
                485                 490                 495     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            500                 505                 510         


Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        515                 520                 525             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    530                 535                 540                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
545                 550                 555                 560 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                565                 570                 575     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            580                 585                 590         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        595                 600                 605             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    610                 615                 620                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
625                 630                 635                 640 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                645                 650                 655     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670         


Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
        675                 680                 685             


Val Glu Glu Asn Pro Gly Pro Arg Met Pro Pro Pro Arg Leu Leu Phe 
    690                 695                 700                 


Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu 
705                 710                 715                 720 


Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys 
                725                 730                 735     


Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser 
            740                 745                 750         


Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly 
        755                 760                 765             


Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser 
    770                 775                 780                 


Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu 
785                 790                 795                 800 


Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu 
                805                 810                 815     


Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu 
            820                 825                 830         


Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met 
        835                 840                 845             


Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu 
    850                 855                 860                 


Gly Glu Pro Pro Cys Val Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu 
865                 870                 875                 880 


Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys 
                885                 890                 895     


Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His 
            900                 905                 910         


Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp 
        915                 920                 925             


Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu 
    930                 935                 940                 


Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly 
945                 950                 955                 960 


Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu 
                965                 970                 975     


Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr 
            980                 985                 990         


Leu Ala Tyr Leu Ile Phe Cys Leu  Cys Ser Leu Val Gly  Ile Leu His 
        995                 1000                 1005             


Leu Gln  Arg Ala Leu Val Leu  Arg Arg Lys Arg 
    1010                 1015                 


<210>  168
<211>  3162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  168
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaagagt ctaagtacgg accgccttgc ccaccgtgcc cagcaccacc tgtggcagga      840

ccgtcagtct tcctcttccc accaaaaccc aaggacaccc tgatgatcag ccggaccccc      900

gaggtgacct gcgtggtggt ggacgtgagc caggaagatc ccgaggtcca gttcaattgg      960

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagttccaa     1020

agcacctacc gggtggtgtc tgtgctgacc gtgctgcacc aggactggct gaacggcaaa     1080

gaatacaagt gcaaggtgtc caacaagggc ctgcccagca gcatcgaaaa gaccatcagc     1140

aaggccaagg gccagcctcg cgagccccag gtgtacaccc tgcctccctc ccaggaagag     1200

atgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     1260

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1320

ctggacagcg acggcagctt cttcctgtac agccggctga ccgtggacaa gagccggtgg     1380

caggaaggca acgtctttag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1440

cagaagagcc tgagcctgtc cctgggcaag atgttctggg tgctggtggt ggtgggcggg     1500

gtgctggcct gctacagcct gctggtgaca gtggccttca tcatcttttg ggtgaaacgg     1560

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1620

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1680

cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg     1740

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc     1800

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac     1860

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg     1920

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc     1980

tacgacgccc tgcacatgca ggccctgccc ccaaggctcg agggcggcgg agagggcaga     2040

ggaagtcttc taacatgcgg tgacgtggag gagaatcccg gccctaggat gcttctcctg     2100

gtgacaagcc ttctgctctg tgagttacca cacccagcat tcctcctgat cccacgcaaa     2160

gtgtgtaacg gaataggtat tggtgaattt aaagactcac tctccataaa tgctacgaat     2220

attaaacact tcaaaaactg cacctccatc agtggcgatc tccacatcct gccggtggca     2280

tttaggggtg actccttcac acatactcct cctctggatc cacaggaact ggatattctg     2340

aaaaccgtaa aggaaatcac agggtttttg ctgattcagg cttggcctga aaacaggacg     2400

gacctccatg cctttgagaa cctagaaatc atacgcggca ggaccaagca acatggtcag     2460

ttttctcttg cagtcgtcag cctgaacata acatccttgg gattacgctc cctcaaggag     2520

ataagtgatg gagatgtgat aatttcagga aacaaaaatt tgtgctatgc aaatacaata     2580

aactggaaaa aactgtttgg gacctccggt cagaaaacca aaattataag caacagaggt     2640

gaaaacagct gcaaggccac aggccaggtc tgccatgcct tgtgctcccc cgagggctgc     2700

tggggcccgg agcccaggga ctgcgtctct tgccggaatg tcagccgagg cagggaatgc     2760

gtggacaagt gcaaccttct ggagggtgag ccaagggagt ttgtggagaa ctctgagtgc     2820

atacagtgcc acccagagtg cctgcctcag gccatgaaca tcacctgcac aggacgggga     2880

ccagacaact gtatccagtg tgcccactac attgacggcc cccactgcgt caagacctgc     2940

ccggcaggag tcatgggaga aaacaacacc ctggtctgga agtacgcaga cgccggccat     3000

gtgtgccacc tgtgccatcc aaactgcacc tacggatgca ctgggccagg tcttgaaggc     3060

tgtccaacga atgggcctaa gatcccgtcc atcgccactg ggatggtggg ggccctcctc     3120

ttgctgctgg tggtggccct ggggatcggc ctcttcatgt ga                        3162


<210>  169
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  169

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
385                 390                 395                 400 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val 
                485                 490                 495     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            500                 505                 510         


Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        515                 520                 525             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    530                 535                 540                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
545                 550                 555                 560 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                565                 570                 575     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            580                 585                 590         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        595                 600                 605             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    610                 615                 620                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
625                 630                 635                 640 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                645                 650                 655     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670         


Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
        675                 680                 685             


Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu 
    690                 695                 700                 


Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys 
705                 710                 715                 720 


Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile 
                725                 730                 735     


Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly 
            740                 745                 750         


Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His 
        755                 760                 765             


Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys 
    770                 775                 780                 


Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr 
785                 790                 795                 800 


Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys 
                805                 810                 815     


Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser 
            820                 825                 830         


Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile 
        835                 840                 845             


Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys 
    850                 855                 860                 


Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly 
865                 870                 875                 880 


Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser 
                885                 890                 895     


Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg 
            900                 905                 910         


Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu 
        915                 920                 925             


Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His 
    930                 935                 940                 


Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly 
945                 950                 955                 960 


Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys 
                965                 970                 975     


Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val 
            980                 985                 990         


Trp Lys Tyr Ala Asp Ala Gly His  Val Cys His Leu Cys  His Pro Asn 
        995                 1000                 1005             


Cys Thr  Tyr Gly Cys Thr Gly  Pro Gly Leu Glu Gly  Cys Pro Thr 
    1010                 1015                 1020             


Asn Gly  Pro Lys Ile Pro Ser  Ile Ala Thr Gly Met  Val Gly Ala 
    1025                 1030                 1035             


Leu Leu  Leu Leu Leu Val Val  Ala Leu Gly Ile Gly  Leu Phe Met 
    1040                 1045                 1050             


<210>  170
<211>  2961
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  170
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcaattggag ccacccgcag      840

ttcgaaaaag gaggtggagg ttcaggtggt ggaggctctg agtctaagta cggaccgccc      900

tgcccccctt gccctatgtt ctgggtgctg gtggtggtcg gaggcgtgct ggcctgctac      960

agcctgctgg tcaccgtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     1140

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     1200

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     1260

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     1380

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     1440

atgcaggccc tgcccccaag gctcgagggc ggcggagagg gcagaggaag tcttctaaca     1500

tgcggtgacg tggaggagaa tcccggccct aggatgctgc tgctggtgac cagcctgctg     1560

ctgtgcgagc tgccccaccc cgcctttctg ctgatccccc aggtgcagct gcaggagtcg     1620

gggccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgttgt ctctggtggc     1680

tccatcagca gtagtaactg gtggagctgg gtccgccagc ccccagggaa ggggctggag     1740

tggattgggg aaatctatca tagtgggagc cccgactaca acccgtccct caagagtcga     1800

gtcaccatat cagtagacaa gtccaggaac cagttctccc tgaagctgag ctctgtgacc     1860

gccgcggaca cggccgtgta ttactgtgca aaggttagta ctggtggttt ctttgactac     1920

tggggccaag gtaccctggt caccgtctcc agtggaggcg gaggatcagg cggagggggc     1980

tccggagggg gaggctctga aattgagctc acccagtctc catcctccct gtctgcatct     2040

gtaggagaca gagtcaccat cacttgccgg gcaagtcaga gcattagcag ctacttaaat     2100

tggtatcagc agaaaccagg gaaagcccct aagctcctga tctatgctgc atccagtttg     2160

caaagtgggg tcccatcaag gttcagtggc agtggatctg ggacagattt cactctcacc     2220

atcagcagtc tgcaacctga agattttgca acttactact gtcaacagag ttacagtacc     2280

cctccaacgt tcggcccagg gaccaaggtg gagatcaaag aacaaaaact catctcagaa     2340

gaggatctgg gaggtggagg ttcaggtggt ggaggctctg agagcaagta cggaccgccc     2400

tgcccccctt gccctatgtt ctgggtgctg gtggtggtcg gaggcgtgct ggcctgctac     2460

agcctgctgg tcaccgtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     2520

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     2580

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     2640

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     2700

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     2760

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     2820

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     2880

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     2940

atgcaggccc tgcccccaag g                                               2961


<210>  171
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  171

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    290                 295                 300                 


Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly 
                485                 490                 495     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met 
            500                 505                 510         


Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
        515                 520                 525             


Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    530                 535                 540                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly 
545                 550                 555                 560 


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
                565                 570                 575     


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp 
            580                 585                 590         


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
        595                 600                 605             


Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln 
            660                 665                 670         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        675                 680                 685             


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
    690                 695                 700                 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
705                 710                 715                 720 


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                725                 730                 735     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            740                 745                 750         


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr 
        755                 760                 765             


Lys Val Glu Ile Lys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
    770                 775                 780                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro 
785                 790                 795                 800 


Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
                805                 810                 815     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            820                 825                 830         


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        835                 840                 845             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    850                 855                 860                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
865                 870                 875                 880 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                885                 890                 895     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            900                 905                 910         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        915                 920                 925             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    930                 935                 940                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
945                 950                 955                 960 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                965                 970                 975     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            980                 985         


<210>  172
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  172
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg       60

atcccccagg tgcagctgca ggagtcgggg ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcgttgtctc tggtggctcc atcagcagta gtaactggtg gagctgggtc      180

cgccagcccc cagggaaggg gctggagtgg attggggaaa tctatcatag tgggagcccc      240

gactacaacc cgtccctcaa gagtcgagtc accatatcag tagacaagtc caggaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcaaag      360

gttagtactg gtggtttctt tgactactgg ggccaaggta ccctggtcac cgtctcgagt      420

ggaggcggag gatcaggcgg agggggctcc ggagggggag gctctgaaat tgagctcacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcagagca ttagcagcta cttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      660

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      720

tactactgtc aacagagtta cagtacccct ccaacgttcg gcccagggac caaggtggag      780

atcaaaggag gtggtggatc cggtggtgga ggctctgaca tcgtgatgac ccagagccct      840

agcagcctgg ccgtgtccgt gggcgagaaa gtgaccatga gctgcaagag cagccagagc      900

ctgctgttca gcagcaacca gaagaactac ctggcctggt atcagcagaa gcccggccag      960

agccccaagc tgctgatcta ctgggccagc accagagaaa gcggcgtgcc cgatagattc     1020

accggctctg gcagcggcac cgacttcacc ctgacaatca gcagcgtgaa ggccgaggac     1080

ctggctgtgt actactgcca gcagttctac agcttccccc ggacctttgg cggaggcacc     1140

aagctggaaa tcaagagagg cggcggagga agcggaggcg gaggatctgg cggagggggc     1200

tccggagggg gaggctctga agtgcagctg gtggaaagtg gcggcggact cgtgaagcct     1260

ggcggctctc tgaagctgag ctgtgccgcc agcggcttca ccttcagcag ctacgccatg     1320

tcctgggtgc gccagacccc cgagaagaga ctggaatggg tggccacagt gtcctacggc     1380

ggcagctaca ccttctaccc cgacaatgtg aagggccggt tcaccatcag ccgggacaac     1440

gccaagaaca acctgtacct gcagatgagc cacctgaagt ccgaggatac cgccatgtac     1500

tattgcgcca gagactacga ctacgatttc ttcgacagct ggggccaggg caccaccgtg     1560

acagtgtcca gcaattggag ccacccgcag ttcgaaaaag gaggtggagg ttcaggtggt     1620

ggaggctctg aatctaagta cggaccgccc tgcccccctt gccctatgtt ctgggtgctg     1680

gtggtggtcg gaggcgtgct ggcctgctac agcctgctgg tcaccgtggc cttcatcatc     1740

ttttgggtga aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1800

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1860

ggaggatgtg aactgcgggt gaagttcagc agaagcgccg acgcccctgc ctaccagcag     1920

ggccagaatc agctgtacaa cgagctgaac ctgggcagaa gggaagagta cgacgtcctg     1980

gataagcgga gaggccggga ccctgagatg ggcggcaagc ctcggcggaa gaacccccag     2040

gaaggcctgt ataacgaact gcagaaagac aagatggccg aggcctacag cgagatcggc     2100

atgaagggcg agcggaggcg gggcaagggc cacgacggcc tgtatcaggg cctgtccacc     2160

gccaccaagg atacctacga cgccctgcac atgcaggccc tgcccccaag g              2211


<210>  173
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  173

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
        275                 280                 285             


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser 
    290                 295                 300                 


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
305                 310                 315                 320 


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
                325                 330                 335     


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            340                 345                 350         


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
        355                 360                 365             


Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    370                 375                 380                 


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                405                 410                 415     


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            420                 425                 430         


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu 
        435                 440                 445             


Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr 
    450                 455                 460                 


Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
465                 470                 475                 480 


Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Glu Asp 
                485                 490                 495     


Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp 
            500                 505                 510         


Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Asn Trp Ser His 
        515                 520                 525             


Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    530                 535                 540                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu 
545                 550                 555                 560 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                565                 570                 575     


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            580                 585                 590         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        595                 600                 605             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    610                 615                 620                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
625                 630                 635                 640 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                645                 650                 655     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            660                 665                 670         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        675                 680                 685             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    690                 695                 700                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
705                 710                 715                 720 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                725                 730                 735     


Arg 
    


<210>  174
<211>  3357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  174
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg       60

atcccccagg tgcagctgca ggagtcgggg ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcgttgtctc tggtggctcc atcagcagta gtaactggtg gagctgggtc      180

cgccagcccc cagggaaggg gctggagtgg attggggaaa tctatcatag tgggagcccc      240

gactacaacc cgtccctcaa gagtcgagtc accatatcag tagacaagtc caggaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcaaag      360

gttagtactg gtggtttctt tgactactgg ggccaaggta ccctggtcac cgtctcgagt      420

ggaggcggag gatcaggcgg agggggctcc ggagggggag gctctgaaat tgagctcacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcagagca ttagcagcta cttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      660

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      720

tactactgtc aacagagtta cagtacccct ccaacgttcg gcccagggac caaggtggag      780

atcaaaggag gtggtggatc cggtggtgga ggctctgaca tcgtgatgac ccagagccct      840

agcagcctgg ccgtgtccgt gggcgagaaa gtgaccatga gctgcaagag cagccagagc      900

ctgctgttca gcagcaacca gaagaactac ctggcctggt atcagcagaa gcccggccag      960

agccccaagc tgctgatcta ctgggccagc accagagaaa gcggcgtgcc cgatagattc     1020

accggctctg gcagcggcac cgacttcacc ctgacaatca gcagcgtgaa ggccgaggac     1080

ctggctgtgt actactgcca gcagttctac agcttccccc ggacctttgg cggaggcacc     1140

aagctggaaa tcaagagagg cggcggagga agcggaggcg gaggatctgg cggagggggc     1200

tccggagggg gaggctctga agtgcagctg gtggaaagtg gcggcggact cgtgaagcct     1260

ggcggctctc tgaagctgag ctgtgccgcc agcggcttca ccttcagcag ctacgccatg     1320

tcctgggtgc gccagacccc cgagaagaga ctggaatggg tggccacagt gtcctacggc     1380

ggcagctaca ccttctaccc cgacaatgtg aagggccggt tcaccatcag ccgggacaac     1440

gccaagaaca acctgtacct gcagatgagc cacctgaagt ccgaggatac cgccatgtac     1500

tattgcgcca gagactacga ctacgatttc ttcgacagct ggggccaggg caccaccgtg     1560

acagtgtcca gcaattggag ccacccgcag ttcgaaaaag gaggtggagg ttcaggtggt     1620

ggaggctctg aatctaagta cggaccgccc tgcccccctt gccctatgtt ctgggtgctg     1680

gtggtggtcg gaggcgtgct ggcctgctac agcctgctgg tcaccgtggc cttcatcatc     1740

ttttgggtga aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1800

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1860

ggaggatgtg aactgcgggt gaagttcagc agaagcgccg acgcccctgc ctaccagcag     1920

ggccagaatc agctgtacaa cgagctgaac ctgggcagaa gggaagagta cgacgtcctg     1980

gataagcgga gaggccggga ccctgagatg ggcggcaagc ctcggcggaa gaacccccag     2040

gaaggcctgt ataacgaact gcagaaagac aagatggccg aggcctacag cgagatcggc     2100

atgaagggcg agcggaggcg gggcaagggc cacgacggcc tgtatcaggg cctgtccacc     2160

gccaccaagg atacctacga cgccctgcac atgcaggccc tgcccccaag gctcgagggc     2220

ggcggagagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct     2280

aggatgcttc tcctggtgac aagccttctg ctctgtgagt taccacaccc agcattcctc     2340

ctgatcccac gcaaagtgtg taacggaata ggtattggtg aatttaaaga ctcactctcc     2400

ataaatgcta cgaatattaa acacttcaaa aactgcacct ccatcagtgg cgatctccac     2460

atcctgccgg tggcatttag gggtgactcc ttcacacata ctcctcctct ggatccacag     2520

gaactggata ttctgaaaac cgtaaaggaa atcacagggt ttttgctgat tcaggcttgg     2580

cctgaaaaca ggacggacct ccatgccttt gagaacctag aaatcatacg cggcaggacc     2640

aagcaacatg gtcagttttc tcttgcagtc gtcagcctga acataacatc cttgggatta     2700

cgctccctca aggagataag tgatggagat gtgataattt caggaaacaa aaatttgtgc     2760

tatgcaaata caataaactg gaaaaaactg tttgggacct ccggtcagaa aaccaaaatt     2820

ataagcaaca gaggtgaaaa cagctgcaag gccacaggcc aggtctgcca tgccttgtgc     2880

tcccccgagg gctgctgggg cccggagccc agggactgcg tctcttgccg gaatgtcagc     2940

cgaggcaggg aatgcgtgga caagtgcaac cttctggagg gtgagccaag ggagtttgtg     3000

gagaactctg agtgcataca gtgccaccca gagtgcctgc ctcaggccat gaacatcacc     3060

tgcacaggac ggggaccaga caactgtatc cagtgtgccc actacattga cggcccccac     3120

tgcgtcaaga cctgcccggc aggagtcatg ggagaaaaca acaccctggt ctggaagtac     3180

gcagacgccg gccatgtgtg ccacctgtgc catccaaact gcacctacgg atgcactggg     3240

ccaggtcttg aaggctgtcc aacgaatggg cctaagatcc cgtccatcgc cactgggatg     3300

gtgggggccc tcctcttgct gctggtggtg gccctgggga tcggcctctt catgtga        3357


<210>  175
<211>  1118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  175

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
        275                 280                 285             


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser 
    290                 295                 300                 


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
305                 310                 315                 320 


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
                325                 330                 335     


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            340                 345                 350         


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
        355                 360                 365             


Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    370                 375                 380                 


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                405                 410                 415     


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            420                 425                 430         


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu 
        435                 440                 445             


Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr 
    450                 455                 460                 


Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
465                 470                 475                 480 


Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His Leu Lys Ser Glu Asp 
                485                 490                 495     


Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp 
            500                 505                 510         


Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Asn Trp Ser His 
        515                 520                 525             


Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    530                 535                 540                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu 
545                 550                 555                 560 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                565                 570                 575     


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            580                 585                 590         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        595                 600                 605             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    610                 615                 620                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
625                 630                 635                 640 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                645                 650                 655     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            660                 665                 670         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        675                 680                 685             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    690                 695                 700                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
705                 710                 715                 720 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                725                 730                 735     


Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
            740                 745                 750         


Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser 
        755                 760                 765             


Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg 
    770                 775                 780                 


Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser 
785                 790                 795                 800 


Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser 
                805                 810                 815     


Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr 
            820                 825                 830         


His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val 
        835                 840                 845             


Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg 
    850                 855                 860                 


Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr 
865                 870                 875                 880 


Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr 
                885                 890                 895     


Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile 
            900                 905                 910         


Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys 
        915                 920                 925             


Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg 
    930                 935                 940                 


Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys 
945                 950                 955                 960 


Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys 
                965                 970                 975     


Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu 
            980                 985                 990         


Glu Gly Glu Pro Arg Glu Phe Val  Glu Asn Ser Glu Cys  Ile Gln Cys 
        995                 1000                 1005             


His Pro  Glu Cys Leu Pro Gln  Ala Met Asn Ile Thr  Cys Thr Gly 
    1010                 1015                 1020             


Arg Gly  Pro Asp Asn Cys Ile  Gln Cys Ala His Tyr  Ile Asp Gly 
    1025                 1030                 1035             


Pro His  Cys Val Lys Thr Cys  Pro Ala Gly Val Met  Gly Glu Asn 
    1040                 1045                 1050             


Asn Thr  Leu Val Trp Lys Tyr  Ala Asp Ala Gly His  Val Cys His 
    1055                 1060                 1065             


Leu Cys  His Pro Asn Cys Thr  Tyr Gly Cys Thr Gly  Pro Gly Leu 
    1070                 1075                 1080             


Glu Gly  Cys Pro Thr Asn Gly  Pro Lys Ile Pro Ser  Ile Ala Thr 
    1085                 1090                 1095             


Gly Met  Val Gly Ala Leu Leu  Leu Leu Leu Val Val  Ala Leu Gly 
    1100                 1105                 1110             


Ile Gly  Leu Phe Met 
    1115             


<210>  176
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  176
ttctgggtgc tggtggtggt cggaggcgtg ctggcctgct acagcctgct ggtcaccgtg       60

gccttcatca tcttttgggt gaaacggggc agaaagaaac tcctgtatat attcaaacaa      120

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca      180

gaagaagaag aaggaggatg tgaactgcgg gtgaagttca gcagaagcgc cgacgcccct      240

gcctaccagc agggccagaa tcagctgtac aacgagctga acctgggcag aagggaagag      300

tacgacgtcc tggataagcg gagaggccgg gaccctgaga tgggcggcaa gcctcggcgg      360

aagaaccccc aggaaggcct gtataacgaa ctgcagaaag acaagatggc cgaggcctac      420

agcgagatcg gcatgaaggg cgagcggagg cggggcaagg gccacgacgg cctgtatcag      480

ggcctgtcca ccgccaccaa ggatacctac gacgccctgc acatgcaggc cctgccccca      540

aggctcgagg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      600

aatcccggcc ctaggatgct tctcctggtg acaagccttc tgctctgtga gttaccacac      660

ccagcattcc tcctgatccc acgcaaagtg tgtaacggaa taggtattgg tgaatttaaa      720

gactcactct ccataaatgc tacgaatatt aaacacttca aaaactgcac ctccatcagt      780

ggcgatctcc acatcctgcc ggtggcattt aggggtgact ccttcacaca tactcctcct      840

ctggatccac aggaactgga tattctgaaa accgtaaagg aaatcacagg gtttttgctg      900

attcaggctt ggcctgaaaa caggacggac ctccatgcct ttgagaacct agaaatcata      960

cgcggcagga ccaagcaaca tggtcagttt tctcttgcag tcgtcagcct gaacataaca     1020

tccttgggat tacgctccct caaggagata agtgatggag atgtgataat ttcaggaaac     1080

aaaaatttgt gctatgcaaa tacaataaac tggaaaaaac tgtttgggac ctccggtcag     1140

aaaaccaaaa ttataagcaa cagaggtgaa aacagctgca aggccacagg ccaggtctgc     1200

catgccttgt gctcccccga gggctgctgg ggcccggagc ccagggactg cgtctcttgc     1260

cggaatgtca gccgaggcag ggaatgcgtg gacaagtgca accttctgga gggtgagcca     1320

agggagtttg tggagaactc tgagtgcata cagtgccacc cagagtgcct gcctcaggcc     1380

atgaacatca cctgcacagg acggggacca gacaactgta tccagtgtgc ccactacatt     1440

gacggccccc actgcgtcaa gacctgcccg gcaggagtca tgggagaaaa caacaccctg     1500

gtctggaagt acgcagacgc cggccatgtg tgccacctgt gccatccaaa ctgcacctac     1560

ggatgcactg ggccaggtct tgaaggctgt ccaacgaatg ggcctaagat cccgtccatc     1620

gccactggga tggtgggggc cctcctcttg ctgctggtgg tggccctggg gatcggcctc     1680

ttcatgtga                                                             1689


<210>  177
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  177

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
            20                  25                  30          


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        35                  40                  45              


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    50                  55                  60                  


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
65                  70                  75                  80  


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                85                  90                  95      


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            100                 105                 110         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        115                 120                 125             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    130                 135                 140                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
145                 150                 155                 160 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                165                 170                 175     


Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu 
            180                 185                 190         


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu 
        195                 200                 205             


Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu 
    210                 215                 220                 


Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys 
225                 230                 235                 240 


Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys 
                245                 250                 255     


Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly 
            260                 265                 270         


Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile 
        275                 280                 285             


Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp 
    290                 295                 300                 


Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile 
305                 310                 315                 320 


Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser 
                325                 330                 335     


Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp 
            340                 345                 350         


Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr 
        355                 360                 365             


Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile 
    370                 375                 380                 


Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys 
385                 390                 395                 400 


His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp 
                405                 410                 415     


Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys 
            420                 425                 430         


Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu 
        435                 440                 445             


Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr 
    450                 455                 460                 


Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile 
465                 470                 475                 480 


Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu 
                485                 490                 495     


Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His 
            500                 505                 510         


Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu 
        515                 520                 525             


Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met 
    530                 535                 540                 


Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu 
545                 550                 555                 560 


Phe Met 
        


<210>  178
<211>  2607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  178
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcaattggag ccacccgcag      840

ttcgaaaaag gaggtggagg ttcaggtggt ggaggctctg agtctaagta cggaccgccc      900

tgcccccctt gccctatgtt ctgggtgctg gtggtggtcg gaggcgtgct ggcctgctac      960

agcctgctgg tcaccgtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     1140

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     1200

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     1260

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     1380

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     1440

atgcaggccc tgcccccaag gctcgagggc ggcggagagg gcagaggaag tcttctaaca     1500

tgcggtgacg tggaggagaa tcccggccct aggatgcttc tcctggtgac aagccttctg     1560

ctctgtgagt taccacaccc agcattcctc ctgatcccac gcaaagtgtg taacggaata     1620

ggtattggtg aatttaaaga ctcactctcc ataaatgcta cgaatattaa acacttcaaa     1680

aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc     1740

ttcacacata ctcctcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa     1800

atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgccttt     1860

gagaacctag aaatcatacg cggcaggacc aagcaacatg gtcagttttc tcttgcagtc     1920

gtcagcctga acataacatc cttgggatta cgctccctca aggagataag tgatggagat     1980

gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg     2040

tttgggacct ccggtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag     2100

gccacaggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc     2160

agggactgcg tctcttgccg gaatgtcagc cgaggcaggg aatgcgtgga caagtgcaac     2220

cttctggagg gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca     2280

gagtgcctgc ctcaggccat gaacatcacc tgcacaggac ggggaccaga caactgtatc     2340

cagtgtgccc actacattga cggcccccac tgcgtcaaga cctgcccggc aggagtcatg     2400

ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc     2460

catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtcc aacgaatggg     2520

cctaagatcc cgtccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg     2580

gccctgggga tcggcctctt catgtga                                         2607


<210>  179
<211>  868
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  179

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    290                 295                 300                 


Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly 
                485                 490                 495     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met 
            500                 505                 510         


Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
        515                 520                 525             


Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
    530                 535                 540                 


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
545                 550                 555                 560 


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
                565                 570                 575     


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
            580                 585                 590         


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
        595                 600                 605             


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
    610                 615                 620                 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
625                 630                 635                 640 


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
                645                 650                 655     


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
            660                 665                 670         


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
        675                 680                 685             


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
    690                 695                 700                 


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
705                 710                 715                 720 


Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
                725                 730                 735     


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
            740                 745                 750         


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
        755                 760                 765             


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
    770                 775                 780                 


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
785                 790                 795                 800 


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
                805                 810                 815     


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
            820                 825                 830         


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr 
        835                 840                 845             


Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile 
    850                 855                 860                 


Gly Leu Phe Met 
865             


<210>  180
<211>  2664
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  180
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcaattggtc tcatcctcag      840

ttcgagaaag gtggaggcgg ttctggcgga ggtggaagca actggagcca cccacagttc      900

gaaaaaggag gtggaggttc aggtggtgga ggctctgaga gcaagtacgg accgccctgc      960

cccccttgcc ctatgttctg ggtgctggtg gtggtcggag gcgtgctggc ctgctacagc     1020

ctgctggtca ccgtggcctt catcatcttt tgggtgaaac ggggcagaaa gaaactcctg     1080

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1140

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcgggtgaa gttcagcaga     1200

agcgccgacg cccctgccta ccagcagggc cagaatcagc tgtacaacga gctgaacctg     1260

ggcagaaggg aagagtacga cgtcctggat aagcggagag gccgggaccc tgagatgggc     1320

ggcaagcctc ggcggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     1380

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgggg caagggccac     1440

gacggcctgt atcagggcct gtccaccgcc accaaggata cctacgacgc cctgcacatg     1500

caggccctgc ccccaaggct cgagggcggc ggagagggca gaggaagtct tctaacatgc     1560

ggtgacgtgg aggagaatcc cggccctagg atgcttctcc tggtgacaag ccttctgctc     1620

tgtgagttac cacacccagc attcctcctg atcccacgca aagtgtgtaa cggaataggt     1680

attggtgaat ttaaagactc actctccata aatgctacga atattaaaca cttcaaaaac     1740

tgcacctcca tcagtggcga tctccacatc ctgccggtgg catttagggg tgactccttc     1800

acacatactc ctcctctgga tccacaggaa ctggatattc tgaaaaccgt aaaggaaatc     1860

acagggtttt tgctgattca ggcttggcct gaaaacagga cggacctcca tgcctttgag     1920

aacctagaaa tcatacgcgg caggaccaag caacatggtc agttttctct tgcagtcgtc     1980

agcctgaaca taacatcctt gggattacgc tccctcaagg agataagtga tggagatgtg     2040

ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa taaactggaa aaaactgttt     2100

gggacctccg gtcagaaaac caaaattata agcaacagag gtgaaaacag ctgcaaggcc     2160

acaggccagg tctgccatgc cttgtgctcc cccgagggct gctggggccc ggagcccagg     2220

gactgcgtct cttgccggaa tgtcagccga ggcagggaat gcgtggacaa gtgcaacctt     2280

ctggagggtg agccaaggga gtttgtggag aactctgagt gcatacagtg ccacccagag     2340

tgcctgcctc aggccatgaa catcacctgc acaggacggg gaccagacaa ctgtatccag     2400

tgtgcccact acattgacgg cccccactgc gtcaagacct gcccggcagg agtcatggga     2460

gaaaacaaca ccctggtctg gaagtacgca gacgccggcc atgtgtgcca cctgtgccat     2520

ccaaactgca cctacggatg cactgggcca ggtcttgaag gctgtccaac gaatgggcct     2580

aagatcccgt ccatcgccac tgggatggtg ggggccctcc tcttgctgct ggtggtggcc     2640

ctggggatcg gcctcttcat gtga                                            2664


<210>  181
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  181

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
305                 310                 315                 320 


Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
                325                 330                 335     


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu 
            500                 505                 510         


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        515                 520                 525             


Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro 
    530                 535                 540                 


His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly 
545                 550                 555                 560 


Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
                565                 570                 575     


His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro 
            580                 585                 590         


Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro 
        595                 600                 605             


Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu 
    610                 615                 620                 


Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu 
625                 630                 635                 640 


Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser 
                645                 650                 655     


Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu 
            660                 665                 670         


Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu 
        675                 680                 685             


Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly 
    690                 695                 700                 


Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala 
705                 710                 715                 720 


Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly 
                725                 730                 735     


Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg 
            740                 745                 750         


Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe 
        755                 760                 765             


Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln 
    770                 775                 780                 


Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln 
785                 790                 795                 800 


Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala 
                805                 810                 815     


Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala 
            820                 825                 830         


Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr 
        835                 840                 845             


Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
    850                 855                 860                 


Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
865                 870                 875                 880 


Leu Gly Ile Gly Leu Phe Met 
                885         


<210>  182
<211>  2571
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  182
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg       60

atcccccagg tgcagctgca ggagtcgggg ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcgttgtctc tggtggctcc atcagcagta gtaactggtg gagctgggtc      180

cgccagcccc cagggaaggg gctggagtgg attggggaaa tctatcatag tgggagcccc      240

gactacaacc cgtccctcaa gagtcgagtc accatatcag tagacaagtc caggaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcaaag      360

gttagtactg gtggtttctt tgactactgg ggccaaggta ccctggtcac cgtctcgagt      420

ggaggcggag gatcaggcgg agggggctcc ggagggggag gctctgaaat tgagctcacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcagagca ttagcagcta cttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      660

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      720

tactactgtc aacagagtta cagtacccct ccaacgttcg gcccagggac caaggtggag      780

atcaaaaatt ggagccaccc gcagttcgaa aaaggaggtg gaggttcagg tggtggaggc      840

tctgaatcta agtacggacc gccctgcccc ccttgcccta tgttctgggt gctggtggtg      900

gtcggaggcg tgctggcctg ctacagcctg ctggtcaccg tggccttcat catcttttgg      960

gtgaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     1020

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1080

tgtgaactgc gggtgaagtt cagcagaagc gccgacgccc ctgcctacca gcagggccag     1140

aatcagctgt acaacgagct gaacctgggc agaagggaag agtacgacgt cctggataag     1200

cggagaggcc gggaccctga gatgggcggc aagcctcggc ggaagaaccc ccaggaaggc     1260

ctgtataacg aactgcagaa agacaagatg gccgaggcct acagcgagat cggcatgaag     1320

ggcgagcgga ggcggggcaa gggccacgac ggcctgtatc agggcctgtc caccgccacc     1380

aaggatacct acgacgccct gcacatgcag gccctgcccc caaggctcga gggcggcgga     1440

gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctaggatg     1500

cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt cctcctgatc     1560

ccacgcaaag tgtgtaacgg aataggtatt ggtgaattta aagactcact ctccataaat     1620

gctacgaata ttaaacactt caaaaactgc acctccatca gtggcgatct ccacatcctg     1680

ccggtggcat ttaggggtga ctccttcaca catactcctc ctctggatcc acaggaactg     1740

gatattctga aaaccgtaaa ggaaatcaca gggtttttgc tgattcaggc ttggcctgaa     1800

aacaggacgg acctccatgc ctttgagaac ctagaaatca tacgcggcag gaccaagcaa     1860

catggtcagt tttctcttgc agtcgtcagc ctgaacataa catccttggg attacgctcc     1920

ctcaaggaga taagtgatgg agatgtgata atttcaggaa acaaaaattt gtgctatgca     1980

aatacaataa actggaaaaa actgtttggg acctccggtc agaaaaccaa aattataagc     2040

aacagaggtg aaaacagctg caaggccaca ggccaggtct gccatgcctt gtgctccccc     2100

gagggctgct ggggcccgga gcccagggac tgcgtctctt gccggaatgt cagccgaggc     2160

agggaatgcg tggacaagtg caaccttctg gagggtgagc caagggagtt tgtggagaac     2220

tctgagtgca tacagtgcca cccagagtgc ctgcctcagg ccatgaacat cacctgcaca     2280

ggacggggac cagacaactg tatccagtgt gcccactaca ttgacggccc ccactgcgtc     2340

aagacctgcc cggcaggagt catgggagaa aacaacaccc tggtctggaa gtacgcagac     2400

gccggccatg tgtgccacct gtgccatcca aactgcacct acggatgcac tgggccaggt     2460

cttgaaggct gtccaacgaa tgggcctaag atcccgtcca tcgccactgg gatggtgggg     2520

gccctcctct tgctgctggt ggtggccctg gggatcggcc tcttcatgtg a              2571


<210>  183
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  183

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro 
        275                 280                 285             


Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
    290                 295                 300                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
305                 310                 315                 320 


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                325                 330                 335     


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            340                 345                 350         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
        355                 360                 365             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
385                 390                 395                 400 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                405                 410                 415     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly 
465                 470                 475                 480 


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
                485                 490                 495     


Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu 
            500                 505                 510         


Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile 
        515                 520                 525             


Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile 
    530                 535                 540                 


Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu 
545                 550                 555                 560 


Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp 
                565                 570                 575     


Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe 
            580                 585                 590         


Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe 
        595                 600                 605             


Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe 
    610                 615                 620                 


Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser 
625                 630                 635                 640 


Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn 
                645                 650                 655     


Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser 
            660                 665                 670         


Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys 
        675                 680                 685             


Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp 
    690                 695                 700                 


Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly 
705                 710                 715                 720 


Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu 
                725                 730                 735     


Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro 
            740                 745                 750         


Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile 
        755                 760                 765             


Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro 
    770                 775                 780                 


Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp 
785                 790                 795                 800 


Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys 
                805                 810                 815     


Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro 
            820                 825                 830         


Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val 
        835                 840                 845             


Ala Leu Gly Ile Gly Leu Phe Met 
    850                 855     


<210>  184
<211>  2628
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  184
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg       60

atcccccagg tgcagctgca ggagtcgggg ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcgttgtctc tggtggctcc atcagcagta gtaactggtg gagctgggtc      180

cgccagcccc cagggaaggg gctggagtgg attggggaaa tctatcatag tgggagcccc      240

gactacaacc cgtccctcaa gagtcgagtc accatatcag tagacaagtc caggaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcaaag      360

gttagtactg gtggtttctt tgactactgg ggccaaggta ccctggtcac cgtctcgagt      420

ggaggcggag gatcaggcgg agggggctcc ggagggggag gctctgaaat tgagctcacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcagagca ttagcagcta cttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      660

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      720

tactactgtc aacagagtta cagtacccct ccaacgttcg gcccagggac caaggtggag      780

atcaaaaatt ggtctcatcc tcagttcgag aaaggtggag gcggttctgg cggaggtgga      840

agcaactgga gccacccaca gttcgaaaaa ggaggtggag gttcaggtgg tggaggctct      900

gagagcaagt acggaccgcc ctgcccccct tgccctatgt tctgggtgct ggtggtggtc      960

ggaggcgtgc tggcctgcta cagcctgctg gtcaccgtgg ccttcatcat cttttgggtg     1020

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1080

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1140

gaactgcggg tgaagttcag cagaagcgcc gacgcccctg cctaccagca gggccagaat     1200

cagctgtaca acgagctgaa cctgggcaga agggaagagt acgacgtcct ggataagcgg     1260

agaggccggg accctgagat gggcggcaag cctcggcgga agaaccccca ggaaggcctg     1320

tataacgaac tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc     1380

gagcggaggc ggggcaaggg ccacgacggc ctgtatcagg gcctgtccac cgccaccaag     1440

gatacctacg acgccctgca catgcaggcc ctgcccccaa ggctcgaggg cggcggagag     1500

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggatgctt     1560

ctcctggtga caagccttct gctctgtgag ttaccacacc cagcattcct cctgatccca     1620

cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct     1680

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg     1740

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat     1800

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac     1860

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat     1920

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc     1980

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat     2040

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac     2100

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag     2160

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg     2220

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct     2280

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga     2340

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag     2400

acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc     2460

ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg gccaggtctt     2520

gaaggctgtc caacgaatgg gcctaagatc ccgtccatcg ccactgggat ggtgggggcc     2580

ctcctcttgc tgctggtggt ggccctgggg atcggcctct tcatgtga                  2628


<210>  185
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  185

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe 
        275                 280                 285             


Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr 
    290                 295                 300                 


Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu 
                485                 490                 495     


Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
            500                 505                 510         


Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu 
        515                 520                 525             


Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys 
    530                 535                 540                 


Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala 
545                 550                 555                 560 


Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu 
                565                 570                 575     


His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro 
            580                 585                 590         


Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile 
        595                 600                 605             


Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu 
    610                 615                 620                 


His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His 
625                 630                 635                 640 


Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly 
                645                 650                 655     


Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly 
            660                 665                 670         


Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe 
        675                 680                 685             


Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn 
    690                 695                 700                 


Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu 
705                 710                 715                 720 


Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val 
                725                 730                 735     


Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu 
            740                 745                 750         


Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu 
        755                 760                 765             


Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp 
    770                 775                 780                 


Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys 
785                 790                 795                 800 


Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys 
                805                 810                 815     


Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr 
            820                 825                 830         


Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro 
        835                 840                 845             


Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu 
    850                 855                 860                 


Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
865                 870                 875 


<210>  186
<211>  2574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  186
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg       60

atcccccagg tgcagctgca ggagtcgggg ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcgttgtctc tggtggctcc atcagcagta gtaactggtg gagctgggtc      180

cgccagcccc cagggaaggg gctggagtgg attggggaaa tctatcatag tgggagcccc      240

gactacaacc cgtccctcaa gagtcgagtc accatatcag tagacaagtc caggaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcaaag      360

gttagtactg gtggtttctt tgactactgg ggccaaggta ccctggtcac cgtctcgagt      420

ggaggcggag gatcaggcgg agggggctcc ggagggggag gctctgaaat tgagctcacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcagagca ttagcagcta cttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      660

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      720

tactactgtc aacagagtta cagtacccct ccaacgttcg gcccagggac caaggtggag      780

atcaaaggag gtggtggatc cgaacaaaaa ctcatctcag aagaggatct gggtggtgga      840

ggctctgaga gcaagtacgg accgccctgc cccccttgcc ctatgttctg ggtgctggtg      900

gtggtcggag gcgtgctggc ctgctacagc ctgctggtca ccgtggcctt catcatcttt      960

tgggtgaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1020

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1080

ggatgtgaac tgcgggtgaa gttcagcaga agcgccgacg cccctgccta ccagcagggc     1140

cagaatcagc tgtacaacga gctgaacctg ggcagaaggg aagagtacga cgtcctggat     1200

aagcggagag gccgggaccc tgagatgggc ggcaagcctc ggcggaagaa cccccaggaa     1260

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     1320

aagggcgagc ggaggcgggg caagggccac gacggcctgt atcagggcct gtccaccgcc     1380

accaaggata cctacgacgc cctgcacatg caggccctgc ccccaaggct cgagggcggc     1440

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctagg     1500

atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg     1560

atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata     1620

aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc     1680

ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa     1740

ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct     1800

gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag     1860

caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc     1920

tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat     1980

gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata     2040

agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc     2100

cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga     2160

ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag     2220

aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc     2280

acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc     2340

gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca     2400

gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca     2460

ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg     2520

ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga           2574


<210>  187
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  187

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
        275                 280                 285             


Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                325                 330                 335     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            340                 345                 350         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
        355                 360                 365             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
385                 390                 395                 400 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                405                 410                 415     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            420                 425                 430         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        435                 440                 445             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    450                 455                 460                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly 
465                 470                 475                 480 


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
                485                 490                 495     


Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
            500                 505                 510         


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
        515                 520                 525             


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
    530                 535                 540                 


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
545                 550                 555                 560 


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
                565                 570                 575     


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
            580                 585                 590         


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
        595                 600                 605             


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
    610                 615                 620                 


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
625                 630                 635                 640 


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
                645                 650                 655     


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
            660                 665                 670         


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
        675                 680                 685             


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
    690                 695                 700                 


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
705                 710                 715                 720 


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
                725                 730                 735     


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
            740                 745                 750         


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
        755                 760                 765             


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
    770                 775                 780                 


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
785                 790                 795                 800 


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
                805                 810                 815     


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile 
            820                 825                 830         


Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val 
        835                 840                 845             


Val Ala Leu Gly Ile Gly Leu Phe Met 
    850                 855         


<210>  188
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  188
ttctgggtgc tggtggtggt cggaggcgtg ctggcctgct acagcctgct ggtcaccgtg       60

gccttcatca tcttttgggt gaaacggggc agaaagaaac tcctgtatat attcaaacaa      120

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca      180

gaagaagaag aaggaggatg tgaactgcgg gtgaagttca gcagaagcgc cgacgcccct      240

gcctaccagc agggccagaa tcagctgtac aacgagctga acctgggcag aagggaagag      300

tacgacgtcc tggataagcg gagaggccgg gaccctgaga tgggcggcaa gcctcggcgg      360

aagaaccccc aggaaggcct gtataacgaa ctgcagaaag acaagatggc cgaggcctac      420

agcgagatcg gcatgaaggg cgagcggagg cggggcaagg gccacgacgg cctgtatcag      480

ggcctgtcca ccgccaccaa ggatacctac gacgccctgc acatgcaggc cctgccccca      540

aggctcgagg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      600

aatcccggcc ctaggatgct tctcctggtg acaagccttc tgctctgtga gttaccacac      660

ccagcattcc tcctgatccc acgcaaagtg tgtaacggaa taggtattgg tgaatttaaa      720

gactcactct ccataaatgc tacgaatatt aaacacttca aaaactgcac ctccatcagt      780

ggcgatctcc acatcctgcc ggtggcattt aggggtgact ccttcacaca tactcctcct      840

ctggatccac aggaactgga tattctgaaa accgtaaagg aaatcacagg gtttttgctg      900

attcaggctt ggcctgaaaa caggacggac ctccatgcct ttgagaacct agaaatcata      960

cgcggcagga ccaagcaaca tggtcagttt tctcttgcag tcgtcagcct gaacataaca     1020

tccttgggat tacgctccct caaggagata agtgatggag atgtgataat ttcaggaaac     1080

aaaaatttgt gctatgcaaa tacaataaac tggaaaaaac tgtttgggac ctccggtcag     1140

aaaaccaaaa ttataagcaa cagaggtgaa aacagctgca aggccacagg ccaggtctgc     1200

catgccttgt gctcccccga gggctgctgg ggcccggagc ccagggactg cgtctcttgc     1260

cggaatgtca gccgaggcag ggaatgcgtg gacaagtgca accttctgga gggtgagcca     1320

agggagtttg tggagaactc tgagtgcata cagtgccacc cagagtgcct gcctcaggcc     1380

atgaacatca cctgcacagg acggggacca gacaactgta tccagtgtgc ccactacatt     1440

gacggccccc actgcgtcaa gacctgcccg gcaggagtca tgggagaaaa caacaccctg     1500

gtctggaagt acgcagacgc cggccatgtg tgccacctgt gccatccaaa ctgcacctac     1560

ggatgcactg ggccaggtct tgaaggctgt ccaacgaatg ggcctaagat cccgtccatc     1620

gccactggga tggtgggggc cctcctcttg ctgctggtgg tggccctggg gatcggcctc     1680

ttcatgtga                                                             1689


<210>  189
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  189

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
            20                  25                  30          


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        35                  40                  45              


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    50                  55                  60                  


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
65                  70                  75                  80  


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                85                  90                  95      


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            100                 105                 110         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        115                 120                 125             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    130                 135                 140                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
145                 150                 155                 160 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                165                 170                 175     


Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu 
            180                 185                 190         


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu 
        195                 200                 205             


Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu 
    210                 215                 220                 


Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys 
225                 230                 235                 240 


Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys 
                245                 250                 255     


Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly 
            260                 265                 270         


Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile 
        275                 280                 285             


Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp 
    290                 295                 300                 


Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile 
305                 310                 315                 320 


Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser 
                325                 330                 335     


Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp 
            340                 345                 350         


Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr 
        355                 360                 365             


Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile 
    370                 375                 380                 


Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys 
385                 390                 395                 400 


His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp 
                405                 410                 415     


Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys 
            420                 425                 430         


Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu 
        435                 440                 445             


Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr 
    450                 455                 460                 


Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile 
465                 470                 475                 480 


Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu 
                485                 490                 495     


Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His 
            500                 505                 510         


Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu 
        515                 520                 525             


Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met 
    530                 535                 540                 


Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu 
545                 550                 555                 560 


Phe Met 
        


<210>  190
<211>  3315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  190
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctgata tcgtgatgac ccagtctcca agcagcctgg ccgtgtccgt gggagagaaa      120

gtgaccatga gctgcaagtc tagccagtct ctgctgttca gcagcaacca gaagaactac      180

ctggcttggt atcaacagaa gcctggacag agccccaagc tgctcatcta ctgggccagc      240

acaagagaaa gcggcgtgcc cgatagattc acaggctctg gaagcggcac agatttcaca      300

ctgacaatca gctccgtgaa ggccgaggac ctggctgtgt actattgtca gcagttctac      360

agcttcccca gaaccttcgg cggaggcacc aagctcgaga tcaaaagagg tggcggaggt      420

agcggtggtg gtggatcagg cggaggtggt agcggcggag gcggaagtga agttcagctg      480

gttgaatctg gcggcggact cgtgaaacca ggcggatctc tgaagctgtc ctgtgccgcc      540

tctggcttca cctttagcag ctacgccatg tcctgggtcc gccaaacacc tgagaagcgg      600

ctggaatggg tcgccacagt gtcttacggc ggcagctaca cattctaccc cgacaacgtg      660

aagggcagat tcaccatctc cagagacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtat tactgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggacaggg aaccaccgtg acagtgtcca gcgaagccgc cgcaaaggaa      840

gctgctgcca aagaagcagc cgctaagcag gtccagctgc aagagtctgg ccctggactg      900

gtcaagccta gcgagacact gagcctgacc tgtgtggtgt ctggcggcag catcagcagc      960

tccaattggt ggtcttgggt ccgacagcct cctggcaaag gcctggaatg gatcggcgag     1020

atctaccact ctggcagccc cgactacaac cccagcctga agtctagagt gaccatcagc     1080

gtggacaaga gccggaacca gttctccctg aagctgagca gcgtgacagc cgccgataca     1140

gccgtgtact actgtgccaa agtgtccacc ggcggctttt tcgactattg gggccagggc     1200

acactggtca cagtttctag cggaggcgga ggatctggtg gcggaggaag tggcggaggc     1260

ggctctgaaa ttgagctgac acagagccct agcagcctgt ctgcctctgt gggcgacaga     1320

gtgacaatca cctgtagagc cagccagagc atcagctcct acctgaactg gtatcagcaa     1380

aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg     1440

ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg     1500

cagcctgagg acttcgccac ctactactgc cagcagagct acagcacccc tcctacattt     1560

ggccctggca ccaaggtgga aatcaaagag tctaagtacg gaccgccctg ccccccttgc     1620

cctatgttct gggtgctggt ggtggtcgga ggcgtgctgg cctgctacag cctgctggtc     1680

accgtggcct tcatcatctt ttgggtgaaa cggggcagaa agaaactcct gtatatattc     1740

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1800

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac     1860

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg     1920

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct     1980

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     2040

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg     2100

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg     2160

cccccaaggc tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg     2220

gaggagaatc ccggccctag gatgcttctc ctggtgacaa gccttctgct ctgtgagtta     2280

ccacacccag cattcctcct gatcccacgc aaagtgtgta acggaatagg tattggtgaa     2340

tttaaagact cactctccat aaatgctacg aatattaaac acttcaaaaa ctgcacctcc     2400

atcagtggcg atctccacat cctgccggtg gcatttaggg gtgactcctt cacacatact     2460

cctcctctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     2520

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcctttga gaacctagaa     2580

atcatacgcg gcaggaccaa gcaacatggt cagttttctc ttgcagtcgt cagcctgaac     2640

ataacatcct tgggattacg ctccctcaag gagataagtg atggagatgt gataatttca     2700

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     2760

ggtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacaggccag     2820

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagcccag ggactgcgtc     2880

tcttgccgga atgtcagccg aggcagggaa tgcgtggaca agtgcaacct tctggagggt     2940

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga gtgcctgcct     3000

caggccatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     3060

tacattgacg gcccccactg cgtcaagacc tgcccggcag gagtcatggg agaaaacaac     3120

accctggtct ggaagtacgc agacgccggc catgtgtgcc acctgtgcca tccaaactgc     3180

acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc taagatcccg     3240

tccatcgcca ctgggatggt gggggccctc ctcttgctgc tggtggtggc cctggggatc     3300

ggcctcttca tgtga                                                      3315


<210>  191
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  191

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
        275                 280                 285             


Lys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
    290                 295                 300                 


Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser 
305                 310                 315                 320 


Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser 
            340                 345                 350         


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe 
        355                 360                 365             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser 
            420                 425                 430         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        435                 440                 445             


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    450                 455                 460                 


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
465                 470                 475                 480 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                485                 490                 495     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            500                 505                 510         


Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
        515                 520                 525             


Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp 
    530                 535                 540                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
545                 550                 555                 560 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
                565                 570                 575     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            580                 585                 590         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        595                 600                 605             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    610                 615                 620                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
625                 630                 635                 640 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                645                 650                 655     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            660                 665                 670         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        675                 680                 685             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    690                 695                 700                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
705                 710                 715                 720 


Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                725                 730                 735     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val 
            740                 745                 750         


Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile 
        755                 760                 765             


Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
    770                 775                 780                 


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
785                 790                 795                 800 


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
                805                 810                 815     


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
            820                 825                 830         


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
        835                 840                 845             


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
    850                 855                 860                 


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
865                 870                 875                 880 


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
                885                 890                 895     


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
            900                 905                 910         


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
        915                 920                 925             


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
    930                 935                 940                 


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
945                 950                 955                 960 


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
                965                 970                 975     


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
            980                 985                 990         


Gln Cys His Pro Glu Cys Leu Pro  Gln Ala Met Asn Ile  Thr Cys Thr 
        995                 1000                 1005             


Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys Ala His  Tyr Ile Asp 
    1010                 1015                 1020             


Gly Pro  His Cys Val Lys Thr  Cys Pro Ala Gly Val  Met Gly Glu 
    1025                 1030                 1035             


Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp Ala Gly  His Val Cys 
    1040                 1045                 1050             


His Leu  Cys His Pro Asn Cys  Thr Tyr Gly Cys Thr  Gly Pro Gly 
    1055                 1060                 1065             


Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys Ile Pro  Ser Ile Ala 
    1070                 1075                 1080             


Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu Leu Val  Val Ala Leu 
    1085                 1090                 1095             


Gly Ile  Gly Leu Phe Met 
    1100                 


<210>  192
<211>  3285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  192
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcggaggtgg tggatcccag      840

gtgcagctgc aggaatctgg ccctggcctc gtgaagccca gcgagacact gagcctgacc      900

tgtgtggtgt ccggcggcag catcagcagc tccaattggt ggtcttgggt gcgccagcct      960

cctggcaagg gcctggaatg gatcggcgag atctaccaca gcggcagccc cgactacaac     1020

cccagcctga agtccagagt gaccatcagc gtggacaaga gccggaacca gttctccctg     1080

aagctgagca gcgtgacagc cgccgatacc gccgtgtact actgcgccaa agtgtccacc     1140

ggcggctttt tcgactactg gggccagggc acactcgtga ccgtgtctag cggaggcgga     1200

ggatctggcg gagggggctc cggaggggga ggctctgaaa ttgagctgac ccagagcccc     1260

agcagcctgt ctgcctctgt gggcgaccgc gtgaccatta cctgtagagc cagccagagc     1320

atcagctcct acctgaactg gtatcagcag aagcccggca aggcccccaa actgctgatc     1380

tacgccgcca gctctctgca gtctggcgtg cccagcagat tttccggcag cggctctggc     1440

accgacttca ccctgaccat ctccagcctg cagcccgagg acttcgccac ctactactgc     1500

cagcagagct acagcacccc ccccacattt ggcccaggca ccaaggtgga aatcaaagag     1560

tctaagtacg gaccgccctg ccccccttgc cctatgttct gggtgctggt ggtggtcgga     1620

ggcgtgctgg cctgctacag cctgctggtc accgtggcct tcatcatctt ttgggtgaaa     1680

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1740

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1800

ctgcgggtga agttcagcag aagcgccgac gcccctgcct accagcaggg ccagaatcag     1860

ctgtacaacg agctgaacct gggcagaagg gaagagtacg acgtcctgga taagcggaga     1920

ggccgggacc ctgagatggg cggcaagcct cggcggaaga acccccagga aggcctgtat     1980

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag     2040

cggaggcggg gcaagggcca cgacggcctg tatcagggcc tgtccaccgc caccaaggat     2100

acctacgacg ccctgcacat gcaggccctg cccccaaggc tcgagggcgg cggagagggc     2160

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctag gatgcttctc     2220

ctggtgacaa gccttctgct ctgtgagtta ccacacccag cattcctcct gatcccacgc     2280

aaagtgtgta acggaatagg tattggtgaa tttaaagact cactctccat aaatgctacg     2340

aatattaaac acttcaaaaa ctgcacctcc atcagtggcg atctccacat cctgccggtg     2400

gcatttaggg gtgactcctt cacacatact cctcctctgg atccacagga actggatatt     2460

ctgaaaaccg taaaggaaat cacagggttt ttgctgattc aggcttggcc tgaaaacagg     2520

acggacctcc atgcctttga gaacctagaa atcatacgcg gcaggaccaa gcaacatggt     2580

cagttttctc ttgcagtcgt cagcctgaac ataacatcct tgggattacg ctccctcaag     2640

gagataagtg atggagatgt gataatttca ggaaacaaaa atttgtgcta tgcaaataca     2700

ataaactgga aaaaactgtt tgggacctcc ggtcagaaaa ccaaaattat aagcaacaga     2760

ggtgaaaaca gctgcaaggc cacaggccag gtctgccatg ccttgtgctc ccccgagggc     2820

tgctggggcc cggagcccag ggactgcgtc tcttgccgga atgtcagccg aggcagggaa     2880

tgcgtggaca agtgcaacct tctggagggt gagccaaggg agtttgtgga gaactctgag     2940

tgcatacagt gccacccaga gtgcctgcct caggccatga acatcacctg cacaggacgg     3000

ggaccagaca actgtatcca gtgtgcccac tacattgacg gcccccactg cgtcaagacc     3060

tgcccggcag gagtcatggg agaaaacaac accctggtct ggaagtacgc agacgccggc     3120

catgtgtgcc acctgtgcca tccaaactgc acctacggat gcactgggcc aggtcttgaa     3180

ggctgtccaa cgaatgggcc taagatcccg tccatcgcca ctgggatggt gggggccctc     3240

ctcttgctgc tggtggtggc cctggggatc ggcctcttca tgtga                     3285


<210>  193
<211>  1094
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  193

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
        275                 280                 285             


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser 
    290                 295                 300                 


Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser 
                325                 330                 335     


Pro Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
            340                 345                 350         


Lys Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe 
    370                 375                 380                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu 
                405                 410                 415     


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            420                 425                 430         


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
    450                 455                 460                 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
        515                 520                 525             


Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    530                 535                 540                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
545                 550                 555                 560 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                565                 570                 575     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            580                 585                 590         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        595                 600                 605             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    610                 615                 620                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
625                 630                 635                 640 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                645                 650                 655     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            660                 665                 670         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        675                 680                 685             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    690                 695                 700                 


Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly 
705                 710                 715                 720 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                725                 730                 735     


Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
            740                 745                 750         


Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile 
        755                 760                 765             


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
    770                 775                 780                 


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
785                 790                 795                 800 


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
                805                 810                 815     


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
            820                 825                 830         


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
        835                 840                 845             


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
    850                 855                 860                 


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
865                 870                 875                 880 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
                885                 890                 895     


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
            900                 905                 910         


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
        915                 920                 925             


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
    930                 935                 940                 


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
945                 950                 955                 960 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
                965                 970                 975     


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
            980                 985                 990         


Met Asn Ile Thr Cys Thr Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys 
        995                 1000                 1005             


Ala His  Tyr Ile Asp Gly Pro  His Cys Val Lys Thr  Cys Pro Ala 
    1010                 1015                 1020             


Gly Val  Met Gly Glu Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp 
    1025                 1030                 1035             


Ala Gly  His Val Cys His Leu  Cys His Pro Asn Cys  Thr Tyr Gly 
    1040                 1045                 1050             


Cys Thr  Gly Pro Gly Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys 
    1055                 1060                 1065             


Ile Pro  Ser Ile Ala Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu 
    1070                 1075                 1080             


Leu Val  Val Ala Leu Gly Ile  Gly Leu Phe Met 
    1085                 1090                 


<210>  194
<211>  3315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  194
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcggtggtgg aggatccggt      840

ggtggaggct ctggtggtgg aggctctcag gtgcagctgc aggagtcggg gccaggactg      900

gtgaagcctt cggagaccct gtccctcacc tgcgttgtct ctggtggctc catcagcagt      960

agtaactggt ggagctgggt ccgccagccc ccagggaagg ggctggagtg gattggggaa     1020

atctatcata gtgggagccc cgactacaac ccgtccctca agagtcgagt caccatatca     1080

gtagacaagt ccaggaacca gttctccctg aagctgagct ctgtgaccgc cgcggacacg     1140

gccgtgtatt actgtgcaaa ggttagtact ggtggtttct ttgactactg gggccaaggt     1200

accctggtca ccgtctcgag tggaggcgga ggatcaggcg gagggggctc cggaggggga     1260

ggctctgaaa ttgagctcac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     1320

gtcaccatca cttgccgggc aagtcagagc attagcagct acttaaattg gtatcagcag     1380

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccagtttgca aagtggggtc     1440

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg     1500

caacctgaag attttgcaac ttactactgt caacagagtt acagtacccc tccaacgttc     1560

ggcccaggga ccaaggtgga gatcaaagaa tctaagtacg gaccgccctg ccccccttgc     1620

cctatgttct gggtgctggt ggtggtcgga ggcgtgctgg cctgctacag cctgctggtc     1680

accgtggcct tcatcatctt ttgggtgaaa cggggcagaa agaaactcct gtatatattc     1740

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1800

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac     1860

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg     1920

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct     1980

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     2040

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg     2100

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg     2160

cccccaaggc tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg     2220

gaggagaatc ccggccctag gatgcttctc ctggtgacaa gccttctgct ctgtgagtta     2280

ccacacccag cattcctcct gatcccacgc aaagtgtgta acggaatagg tattggtgaa     2340

tttaaagact cactctccat aaatgctacg aatattaaac acttcaaaaa ctgcacctcc     2400

atcagtggcg atctccacat cctgccggtg gcatttaggg gtgactcctt cacacatact     2460

cctcctctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     2520

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcctttga gaacctagaa     2580

atcatacgcg gcaggaccaa gcaacatggt cagttttctc ttgcagtcgt cagcctgaac     2640

ataacatcct tgggattacg ctccctcaag gagataagtg atggagatgt gataatttca     2700

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     2760

ggtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacaggccag     2820

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagcccag ggactgcgtc     2880

tcttgccgga atgtcagccg aggcagggaa tgcgtggaca agtgcaacct tctggagggt     2940

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga gtgcctgcct     3000

caggccatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     3060

tacattgacg gcccccactg cgtcaagacc tgcccggcag gagtcatggg agaaaacaac     3120

accctggtct ggaagtacgc agacgccggc catgtgtgcc acctgtgcca tccaaactgc     3180

acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc taagatcccg     3240

tccatcgcca ctgggatggt gggggccctc ctcttgctgc tggtggtggc cctggggatc     3300

ggcctcttca tgtga                                                      3315


<210>  195
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  195

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
    290                 295                 300                 


Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser 
305                 310                 315                 320 


Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser 
            340                 345                 350         


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe 
        355                 360                 365             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser 
            420                 425                 430         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        435                 440                 445             


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    450                 455                 460                 


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
465                 470                 475                 480 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                485                 490                 495     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            500                 505                 510         


Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
        515                 520                 525             


Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp 
    530                 535                 540                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
545                 550                 555                 560 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
                565                 570                 575     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            580                 585                 590         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        595                 600                 605             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    610                 615                 620                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
625                 630                 635                 640 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                645                 650                 655     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            660                 665                 670         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        675                 680                 685             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    690                 695                 700                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
705                 710                 715                 720 


Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                725                 730                 735     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val 
            740                 745                 750         


Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile 
        755                 760                 765             


Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
    770                 775                 780                 


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
785                 790                 795                 800 


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
                805                 810                 815     


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
            820                 825                 830         


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
        835                 840                 845             


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
    850                 855                 860                 


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
865                 870                 875                 880 


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
                885                 890                 895     


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
            900                 905                 910         


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
        915                 920                 925             


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
    930                 935                 940                 


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
945                 950                 955                 960 


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
                965                 970                 975     


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
            980                 985                 990         


Gln Cys His Pro Glu Cys Leu Pro  Gln Ala Met Asn Ile  Thr Cys Thr 
        995                 1000                 1005             


Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys Ala His  Tyr Ile Asp 
    1010                 1015                 1020             


Gly Pro  His Cys Val Lys Thr  Cys Pro Ala Gly Val  Met Gly Glu 
    1025                 1030                 1035             


Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp Ala Gly  His Val Cys 
    1040                 1045                 1050             


His Leu  Cys His Pro Asn Cys  Thr Tyr Gly Cys Thr  Gly Pro Gly 
    1055                 1060                 1065             


Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys Ile Pro  Ser Ile Ala 
    1070                 1075                 1080             


Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu Leu Val  Val Ala Leu 
    1085                 1090                 1095             


Gly Ile  Gly Leu Phe Met 
    1100                 


<210>  196
<211>  3330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  196
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atccccgaca tcgtgatgac ccagagccct agcagcctgg ccgtgtccgt gggcgagaaa      120

gtgaccatga gctgcaagag cagccagagc ctgctgttca gcagcaacca gaagaactac      180

ctggcctggt atcagcagaa gcccggccag agccccaagc tgctgatcta ctgggccagc      240

accagagaaa gcggcgtgcc cgatagattc accggctctg gcagcggcac cgacttcacc      300

ctgacaatca gcagcgtgaa ggccgaggac ctggctgtgt actactgcca gcagttctac      360

agcttccccc ggacctttgg cggaggcacc aagctggaaa tcaagagagg cggcggagga      420

agcggaggcg gaggatctgg cggagggggc tccggagggg gaggctctga agtgcagctg      480

gtggaaagtg gcggcggact cgtgaagcct ggcggctctc tgaagctgag ctgtgccgcc      540

agcggcttca ccttcagcag ctacgccatg tcctgggtgc gccagacccc cgagaagaga      600

ctggaatggg tggccacagt gtcctacggc ggcagctaca ccttctaccc cgacaatgtg      660

aagggccggt tcaccatcag ccgggacaac gccaagaaca acctgtacct gcagatgagc      720

cacctgaagt ccgaggatac cgccatgtac tattgcgcca gagactacga ctacgatttc      780

ttcgacagct ggggccaggg caccaccgtg acagtgtcca gcggtggagg cggcagtggc      840

ggaggtggat ccggaggggg cggttccggt ggcgggggat ctcaggtgca gctgcaggaa      900

tctggccctg gcctcgtgaa gcccagcgag acactgagcc tgacctgtgt ggtgtccggc      960

ggcagcatca gcagctccaa ttggtggtct tgggtgcgcc agcctcctgg caagggcctg     1020

gaatggatcg gcgagatcta ccacagcggc agccccgact acaaccccag cctgaagtcc     1080

agagtgacca tcagcgtgga caagagccgg aaccagttct ccctgaagct gagcagcgtg     1140

acagccgccg ataccgccgt gtactactgc gccaaagtgt ccaccggcgg ctttttcgac     1200

tactggggcc agggcacact cgtgaccgtg tctagcggag gcggaggatc tggcggaggg     1260

ggctccggag ggggaggctc tgaaattgag ctgacccaga gccccagcag cctgtctgcc     1320

tctgtgggcg accgcgtgac cattacctgt agagccagcc agagcatcag ctcctacctg     1380

aactggtatc agcagaagcc cggcaaggcc cccaaactgc tgatctacgc cgccagctct     1440

ctgcagtctg gcgtgcccag cagattttcc ggcagcggct ctggcaccga cttcaccctg     1500

accatctcca gcctgcagcc cgaggacttc gccacctact actgccagca gagctacagc     1560

acccccccca catttggccc aggcaccaag gtggaaatca aagagtctaa gtacggaccg     1620

ccctgccccc cttgccctat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc     1680

tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa     1740

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1800

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc     1860

agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg     1920

aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag     1980

atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     2040

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag     2100

ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg     2160

cacatgcagg ccctgccccc aaggctcgag ggcggcggag agggcagagg aagtcttcta     2220

acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt     2280

ctgctctgtg agttaccaca cccagcattc ctcctgatcc cacgcaaagt gtgtaacgga     2340

ataggtattg gtgaatttaa agactcactc tccataaatg ctacgaatat taaacacttc     2400

aaaaactgca cctccatcag tggcgatctc cacatcctgc cggtggcatt taggggtgac     2460

tccttcacac atactcctcc tctggatcca caggaactgg atattctgaa aaccgtaaag     2520

gaaatcacag ggtttttgct gattcaggct tggcctgaaa acaggacgga cctccatgcc     2580

tttgagaacc tagaaatcat acgcggcagg accaagcaac atggtcagtt ttctcttgca     2640

gtcgtcagcc tgaacataac atccttggga ttacgctccc tcaaggagat aagtgatgga     2700

gatgtgataa tttcaggaaa caaaaatttg tgctatgcaa atacaataaa ctggaaaaaa     2760

ctgtttggga cctccggtca gaaaaccaaa attataagca acagaggtga aaacagctgc     2820

aaggccacag gccaggtctg ccatgccttg tgctcccccg agggctgctg gggcccggag     2880

cccagggact gcgtctcttg ccggaatgtc agccgaggca gggaatgcgt ggacaagtgc     2940

aaccttctgg agggtgagcc aagggagttt gtggagaact ctgagtgcat acagtgccac     3000

ccagagtgcc tgcctcaggc catgaacatc acctgcacag gacggggacc agacaactgt     3060

atccagtgtg cccactacat tgacggcccc cactgcgtca agacctgccc ggcaggagtc     3120

atgggagaaa acaacaccct ggtctggaag tacgcagacg ccggccatgt gtgccacctg     3180

tgccatccaa actgcaccta cggatgcact gggccaggtc ttgaaggctg tccaacgaat     3240

gggcctaaga tcccgtccat cgccactggg atggtggggg ccctcctctt gctgctggtg     3300

gtggccctgg ggatcggcct cttcatgtga                                      3330


<210>  197
<211>  1109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  197

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            180                 185                 190         


Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser 
        195                 200                 205             


Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser 
225                 230                 235                 240 


His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr 
                245                 250                 255     


Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
    290                 295                 300                 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
305                 310                 315                 320 


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
            340                 345                 350         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
        355                 360                 365             


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
385                 390                 395                 400 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
            420                 425                 430         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        435                 440                 445             


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
465                 470                 475                 480 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                485                 490                 495     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            500                 505                 510         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
        515                 520                 525             


Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    530                 535                 540                 


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
545                 550                 555                 560 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
                565                 570                 575     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            580                 585                 590         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        595                 600                 605             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg 
                725                 730                 735     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
            740                 745                 750         


Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
        755                 760                 765             


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
    770                 775                 780                 


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
785                 790                 795                 800 


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
                805                 810                 815     


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
            820                 825                 830         


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
        835                 840                 845             


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
    850                 855                 860                 


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
865                 870                 875                 880 


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
                885                 890                 895     


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
            900                 905                 910         


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
        915                 920                 925             


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
    930                 935                 940                 


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
945                 950                 955                 960 


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
                965                 970                 975     


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
            980                 985                 990         


Asn Ser Glu Cys Ile Gln Cys His  Pro Glu Cys Leu Pro  Gln Ala Met 
        995                 1000                 1005             


Asn Ile  Thr Cys Thr Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys 
    1010                 1015                 1020             


Ala His  Tyr Ile Asp Gly Pro  His Cys Val Lys Thr  Cys Pro Ala 
    1025                 1030                 1035             


Gly Val  Met Gly Glu Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp 
    1040                 1045                 1050             


Ala Gly  His Val Cys His Leu  Cys His Pro Asn Cys  Thr Tyr Gly 
    1055                 1060                 1065             


Cys Thr  Gly Pro Gly Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys 
    1070                 1075                 1080             


Ile Pro  Ser Ile Ala Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu 
    1085                 1090                 1095             


Leu Val  Val Ala Leu Gly Ile  Gly Leu Phe Met 
    1100                 1105                 


<210>  198
<211>  3315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  198
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctgca agagtctggc cctggactgg tcaagcctag cgagacactg      120

agcctgacct gtgtggtgtc tggcggcagc atcagcagct ccaattggtg gtcttgggtc      180

cgacagcctc ctggcaaagg cctggaatgg atcggcgaga tctaccactc tggcagcccc      240

gactacaacc ccagcctgaa gtctagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgatacag ccgtgtacta ctgtgccaaa      360

gtgtccaccg gcggcttttt cgactattgg ggccagggca cactggtcac agtttctagc      420

ggaggcggag gatctggtgg cggaggaagt ggcggaggcg gctctgaaat tgagctgaca      480

cagagcccta gcagcctgtc tgcctctgtg ggcgacagag tgacaatcac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaaa agcccggcaa ggcccctaaa      600

ctgctgatct atgccgccag ctctctgcag tctggcgtgc catctagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccata tctagcctgc agcctgagga cttcgccacc      720

tactactgcc agcagagcta cagcacccct cctacatttg gccctggcac caaggtggaa      780

atcaaagaag ccgccgcaaa ggaagctgct gccaaagaag cagccgctaa ggatatcgtg      840

atgacccagt ctccaagcag cctggccgtg tccgtgggag agaaagtgac catgagctgc      900

aagtctagcc agtctctgct gttcagcagc aaccagaaga actacctggc ttggtatcaa      960

cagaagcctg gacagagccc caagctgctc atctactggg ccagcacaag agaaagcggc     1020

gtgcccgata gattcacagg ctctggaagc ggcacagatt tcacactgac aatcagctcc     1080

gtgaaggccg aggacctggc tgtgtactat tgtcagcagt tctacagctt ccccagaacc     1140

ttcggcggag gcaccaagct cgagatcaaa agaggtggcg gaggtagcgg tggtggtgga     1200

tcaggcggag gtggtagcgg cggaggcgga agtgaagttc agctggttga atctggcggc     1260

ggactcgtga aaccaggcgg atctctgaag ctgtcctgtg ccgcctctgg cttcaccttt     1320

agcagctacg ccatgtcctg ggtccgccaa acacctgaga agcggctgga atgggtcgcc     1380

acagtgtctt acggcggcag ctacacattc taccccgaca acgtgaaggg cagattcacc     1440

atctccagag acaacgccaa gaacaacctg tacctgcaga tgagccacct gaagtccgag     1500

gataccgcca tgtattactg cgccagagac tacgactacg atttcttcga cagctgggga     1560

cagggaacca ccgtgacagt gtccagcgag tctaagtacg gaccgccctg ccccccttgc     1620

cctatgttct gggtgctggt ggtggtcgga ggcgtgctgg cctgctacag cctgctggtc     1680

accgtggcct tcatcatctt ttgggtgaaa cggggcagaa agaaactcct gtatatattc     1740

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1800

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac     1860

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg     1920

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct     1980

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     2040

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg     2100

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg     2160

cccccaaggc tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg     2220

gaggagaatc ccggccctag gatgcttctc ctggtgacaa gccttctgct ctgtgagtta     2280

ccacacccag cattcctcct gatcccacgc aaagtgtgta acggaatagg tattggtgaa     2340

tttaaagact cactctccat aaatgctacg aatattaaac acttcaaaaa ctgcacctcc     2400

atcagtggcg atctccacat cctgccggtg gcatttaggg gtgactcctt cacacatact     2460

cctcctctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     2520

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcctttga gaacctagaa     2580

atcatacgcg gcaggaccaa gcaacatggt cagttttctc ttgcagtcgt cagcctgaac     2640

ataacatcct tgggattacg ctccctcaag gagataagtg atggagatgt gataatttca     2700

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     2760

ggtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacaggccag     2820

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagcccag ggactgcgtc     2880

tcttgccgga atgtcagccg aggcagggaa tgcgtggaca agtgcaacct tctggagggt     2940

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga gtgcctgcct     3000

caggccatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     3060

tacattgacg gcccccactg cgtcaagacc tgcccggcag gagtcatggg agaaaacaac     3120

accctggtct ggaagtacgc agacgccggc catgtgtgcc acctgtgcca tccaaactgc     3180

acctacggat gcactgggcc aggtcttgaa ggctgtccaa cgaatgggcc taagatcccg     3240

tccatcgcca ctgggatggt gggggccctc ctcttgctgc tggtggtggc cctggggatc     3300

ggcctcttca tgtga                                                      3315


<210>  199
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  199

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            260                 265                 270         


Glu Ala Ala Ala Lys Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
        275                 280                 285             


Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
    290                 295                 300                 


Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
305                 310                 315                 320 


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
                325                 330                 335     


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
            340                 345                 350         


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
        355                 360                 365             


Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly 
    370                 375                 380                 


Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
                405                 410                 415     


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
            420                 425                 430         


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
        435                 440                 445             


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr Val Ser Tyr 
    450                 455                 460                 


Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr 
465                 470                 475                 480 


Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser His 
                485                 490                 495     


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Tyr Asp 
            500                 505                 510         


Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        515                 520                 525             


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp 
    530                 535                 540                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
545                 550                 555                 560 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
                565                 570                 575     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            580                 585                 590         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        595                 600                 605             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    610                 615                 620                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
625                 630                 635                 640 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                645                 650                 655     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            660                 665                 670         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        675                 680                 685             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    690                 695                 700                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
705                 710                 715                 720 


Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                725                 730                 735     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val 
            740                 745                 750         


Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile 
        755                 760                 765             


Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
    770                 775                 780                 


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
785                 790                 795                 800 


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
                805                 810                 815     


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
            820                 825                 830         


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
        835                 840                 845             


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
    850                 855                 860                 


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
865                 870                 875                 880 


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
                885                 890                 895     


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
            900                 905                 910         


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
        915                 920                 925             


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
    930                 935                 940                 


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
945                 950                 955                 960 


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
                965                 970                 975     


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
            980                 985                 990         


Gln Cys His Pro Glu Cys Leu Pro  Gln Ala Met Asn Ile  Thr Cys Thr 
        995                 1000                 1005             


Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys Ala His  Tyr Ile Asp 
    1010                 1015                 1020             


Gly Pro  His Cys Val Lys Thr  Cys Pro Ala Gly Val  Met Gly Glu 
    1025                 1030                 1035             


Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp Ala Gly  His Val Cys 
    1040                 1045                 1050             


His Leu  Cys His Pro Asn Cys  Thr Tyr Gly Cys Thr  Gly Pro Gly 
    1055                 1060                 1065             


Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys Ile Pro  Ser Ile Ala 
    1070                 1075                 1080             


Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu Leu Val  Val Ala Leu 
    1085                 1090                 1095             


Gly Ile  Gly Leu Phe Met 
    1100                 


<210>  200
<211>  3285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  200
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg      120

agcctgacct gtgtggtgtc cggcggcagc atcagcagct ccaattggtg gtcttgggtg      180

cgccagcctc ctggcaaggg cctggaatgg atcggcgaga tctaccacag cggcagcccc      240

gactacaacc ccagcctgaa gtccagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgataccg ccgtgtacta ctgcgccaaa      360

gtgtccaccg gcggcttttt cgactactgg ggccagggca cactcgtgac cgtgtctagc      420

ggaggcggag gatctggcgg agggggctcc ggagggggag gctctgaaat tgagctgacc      480

cagagcccca gcagcctgtc tgcctctgtg ggcgaccgcg tgaccattac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaga agcccggcaa ggcccccaaa      600

ctgctgatct acgccgccag ctctctgcag tctggcgtgc ccagcagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccatc tccagcctgc agcccgagga cttcgccacc      720

tactactgcc agcagagcta cagcaccccc cccacatttg gcccaggcac caaggtggaa      780

atcaaaggag gtggtggatc cgacatcgtg atgacccaga gccctagcag cctggccgtg      840

tccgtgggcg agaaagtgac catgagctgc aagagcagcc agagcctgct gttcagcagc      900

aaccagaaga actacctggc ctggtatcag cagaagcccg gccagagccc caagctgctg      960

atctactggg ccagcaccag agaaagcggc gtgcccgata gattcaccgg ctctggcagc     1020

ggcaccgact tcaccctgac aatcagcagc gtgaaggccg aggacctggc tgtgtactac     1080

tgccagcagt tctacagctt cccccggacc tttggcggag gcaccaagct ggaaatcaag     1140

agaggcggcg gaggaagcgg aggcggagga tctggcggag ggggctccgg agggggaggc     1200

tctgaagtgc agctggtgga aagtggcggc ggactcgtga agcctggcgg ctctctgaag     1260

ctgagctgtg ccgccagcgg cttcaccttc agcagctacg ccatgtcctg ggtgcgccag     1320

acccccgaga agagactgga atgggtggcc acagtgtcct acggcggcag ctacaccttc     1380

taccccgaca atgtgaaggg ccggttcacc atcagccggg acaacgccaa gaacaacctg     1440

tacctgcaga tgagccacct gaagtccgag gataccgcca tgtactattg cgccagagac     1500

tacgactacg atttcttcga cagctggggc cagggcacca ccgtgacagt gtccagcgag     1560

tctaagtacg gaccgccctg ccccccttgc cctatgttct gggtgctggt ggtggtcgga     1620

ggcgtgctgg cctgctacag cctgctggtc accgtggcct tcatcatctt ttgggtgaaa     1680

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1740

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1800

ctgcgggtga agttcagcag aagcgccgac gcccctgcct accagcaggg ccagaatcag     1860

ctgtacaacg agctgaacct gggcagaagg gaagagtacg acgtcctgga taagcggaga     1920

ggccgggacc ctgagatggg cggcaagcct cggcggaaga acccccagga aggcctgtat     1980

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag     2040

cggaggcggg gcaagggcca cgacggcctg tatcagggcc tgtccaccgc caccaaggat     2100

acctacgacg ccctgcacat gcaggccctg cccccaaggc tcgagggcgg cggagagggc     2160

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctag gatgcttctc     2220

ctggtgacaa gccttctgct ctgtgagtta ccacacccag cattcctcct gatcccacgc     2280

aaagtgtgta acggaatagg tattggtgaa tttaaagact cactctccat aaatgctacg     2340

aatattaaac acttcaaaaa ctgcacctcc atcagtggcg atctccacat cctgccggtg     2400

gcatttaggg gtgactcctt cacacatact cctcctctgg atccacagga actggatatt     2460

ctgaaaaccg taaaggaaat cacagggttt ttgctgattc aggcttggcc tgaaaacagg     2520

acggacctcc atgcctttga gaacctagaa atcatacgcg gcaggaccaa gcaacatggt     2580

cagttttctc ttgcagtcgt cagcctgaac ataacatcct tgggattacg ctccctcaag     2640

gagataagtg atggagatgt gataatttca ggaaacaaaa atttgtgcta tgcaaataca     2700

ataaactgga aaaaactgtt tgggacctcc ggtcagaaaa ccaaaattat aagcaacaga     2760

ggtgaaaaca gctgcaaggc cacaggccag gtctgccatg ccttgtgctc ccccgagggc     2820

tgctggggcc cggagcccag ggactgcgtc tcttgccgga atgtcagccg aggcagggaa     2880

tgcgtggaca agtgcaacct tctggagggt gagccaaggg agtttgtgga gaactctgag     2940

tgcatacagt gccacccaga gtgcctgcct caggccatga acatcacctg cacaggacgg     3000

ggaccagaca actgtatcca gtgtgcccac tacattgacg gcccccactg cgtcaagacc     3060

tgcccggcag gagtcatggg agaaaacaac accctggtct ggaagtacgc agacgccggc     3120

catgtgtgcc acctgtgcca tccaaactgc acctacggat gcactgggcc aggtcttgaa     3180

ggctgtccaa cgaatgggcc taagatcccg tccatcgcca ctgggatggt gggggccctc     3240

ctcttgctgc tggtggtggc cctggggatc ggcctcttca tgtga                     3285


<210>  201
<211>  1094
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  201

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met 
        275                 280                 285             


Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn 
    290                 295                 300                 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
305                 310                 315                 320 


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr 
                325                 330                 335     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys 
            340                 345                 350         


Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro 
        355                 360                 365             


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly 
                405                 410                 415     


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            420                 425                 430         


Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp 
        435                 440                 445             


Val Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn 
    450                 455                 460                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu 
465                 470                 475                 480 


Tyr Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
                485                 490                 495     


Cys Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly 
            500                 505                 510         


Thr Thr Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
        515                 520                 525             


Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    530                 535                 540                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
545                 550                 555                 560 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                565                 570                 575     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            580                 585                 590         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        595                 600                 605             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    610                 615                 620                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
625                 630                 635                 640 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                645                 650                 655     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            660                 665                 670         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        675                 680                 685             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    690                 695                 700                 


Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly 
705                 710                 715                 720 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                725                 730                 735     


Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
            740                 745                 750         


Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile 
        755                 760                 765             


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
    770                 775                 780                 


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
785                 790                 795                 800 


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
                805                 810                 815     


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
            820                 825                 830         


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
        835                 840                 845             


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
    850                 855                 860                 


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
865                 870                 875                 880 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
                885                 890                 895     


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
            900                 905                 910         


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
        915                 920                 925             


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
    930                 935                 940                 


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
945                 950                 955                 960 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
                965                 970                 975     


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
            980                 985                 990         


Met Asn Ile Thr Cys Thr Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys 
        995                 1000                 1005             


Ala His  Tyr Ile Asp Gly Pro  His Cys Val Lys Thr  Cys Pro Ala 
    1010                 1015                 1020             


Gly Val  Met Gly Glu Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp 
    1025                 1030                 1035             


Ala Gly  His Val Cys His Leu  Cys His Pro Asn Cys  Thr Tyr Gly 
    1040                 1045                 1050             


Cys Thr  Gly Pro Gly Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys 
    1055                 1060                 1065             


Ile Pro  Ser Ile Ala Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu 
    1070                 1075                 1080             


Leu Val  Val Ala Leu Gly Ile  Gly Leu Phe Met 
    1085                 1090                 


<210>  202
<211>  3330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  202
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctgca agagtctggc cctggactgg tcaagcctag cgagacactg      120

agcctgacct gtgtggtgtc tggcggcagc atcagcagct ccaattggtg gtcttgggtc      180

cgacagcctc ctggcaaagg cctggaatgg atcggcgaga tctaccactc tggcagcccc      240

gactacaacc ccagcctgaa gtctagagtg accatcagcg tggacaagag ccggaaccag      300

ttctccctga agctgagcag cgtgacagcc gccgatacag ccgtgtacta ctgtgccaaa      360

gtgtccaccg gcggcttttt cgactattgg ggccagggca cactggtcac agtttctagc      420

ggaggcggag gatctggtgg cggaggaagt ggcggaggcg gctctgaaat tgagctgaca      480

cagagcccta gcagcctgtc tgcctctgtg ggcgacagag tgacaatcac ctgtagagcc      540

agccagagca tcagctccta cctgaactgg tatcagcaaa agcccggcaa ggcccctaaa      600

ctgctgatct atgccgccag ctctctgcag tctggcgtgc catctagatt ttccggcagc      660

ggctctggca ccgacttcac cctgaccata tctagcctgc agcctgagga cttcgccacc      720

tactactgcc agcagagcta cagcacccct cctacatttg gccctggcac caaggtggaa      780

atcaaaggcg gtggtggcag tggtggcggt ggctcaggtg gcggcggttc aggcggtggc      840

ggatctgata tcgtgatgac ccagtctcca agcagcctgg ccgtgtccgt gggagagaaa      900

gtgaccatga gctgcaagtc tagccagtct ctgctgttca gcagcaacca gaagaactac      960

ctggcttggt atcaacagaa gcctggacag agccccaagc tgctcatcta ctgggccagc     1020

acaagagaaa gcggcgtgcc cgatagattc acaggctctg gaagcggcac agatttcaca     1080

ctgacaatca gctccgtgaa ggccgaggac ctggctgtgt actattgtca gcagttctac     1140

agcttcccca gaaccttcgg cggaggcacc aagctcgaga tcaaaagagg tggcggaggt     1200

agcggtggtg gtggatcagg cggaggtggt agcggcggag gcggaagtga agttcagctg     1260

gttgaatctg gcggcggact cgtgaaacca ggcggatctc tgaagctgtc ctgtgccgcc     1320

tctggcttca cctttagcag ctacgccatg tcctgggtcc gccaaacacc tgagaagcgg     1380

ctggaatggg tcgccacagt gtcttacggc ggcagctaca cattctaccc cgacaacgtg     1440

aagggcagat tcaccatctc cagagacaac gccaagaaca acctgtacct gcagatgagc     1500

cacctgaagt ccgaggatac cgccatgtat tactgcgcca gagactacga ctacgatttc     1560

ttcgacagct ggggacaggg aaccaccgtg acagtgtcca gcgagtctaa gtacggaccg     1620

ccctgccccc cttgccctat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc     1680

tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa     1740

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1800

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc     1860

agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg     1920

aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag     1980

atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     2040

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag     2100

ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg     2160

cacatgcagg ccctgccccc aaggctcgag ggcggcggag agggcagagg aagtcttcta     2220

acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt     2280

ctgctctgtg agttaccaca cccagcattc ctcctgatcc cacgcaaagt gtgtaacgga     2340

ataggtattg gtgaatttaa agactcactc tccataaatg ctacgaatat taaacacttc     2400

aaaaactgca cctccatcag tggcgatctc cacatcctgc cggtggcatt taggggtgac     2460

tccttcacac atactcctcc tctggatcca caggaactgg atattctgaa aaccgtaaag     2520

gaaatcacag ggtttttgct gattcaggct tggcctgaaa acaggacgga cctccatgcc     2580

tttgagaacc tagaaatcat acgcggcagg accaagcaac atggtcagtt ttctcttgca     2640

gtcgtcagcc tgaacataac atccttggga ttacgctccc tcaaggagat aagtgatgga     2700

gatgtgataa tttcaggaaa caaaaatttg tgctatgcaa atacaataaa ctggaaaaaa     2760

ctgtttggga cctccggtca gaaaaccaaa attataagca acagaggtga aaacagctgc     2820

aaggccacag gccaggtctg ccatgccttg tgctcccccg agggctgctg gggcccggag     2880

cccagggact gcgtctcttg ccggaatgtc agccgaggca gggaatgcgt ggacaagtgc     2940

aaccttctgg agggtgagcc aagggagttt gtggagaact ctgagtgcat acagtgccac     3000

ccagagtgcc tgcctcaggc catgaacatc acctgcacag gacggggacc agacaactgt     3060

atccagtgtg cccactacat tgacggcccc cactgcgtca agacctgccc ggcaggagtc     3120

atgggagaaa acaacaccct ggtctggaag tacgcagacg ccggccatgt gtgccacctg     3180

tgccatccaa actgcaccta cggatgcact gggccaggtc ttgaaggctg tccaacgaat     3240

gggcctaaga tcccgtccat cgccactggg atggtggggg ccctcctctt gctgctggtg     3300

gtggccctgg ggatcggcct cttcatgtga                                      3330


<210>  203
<211>  1109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR construct

<400>  203

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
        275                 280                 285             


Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser 
    290                 295                 300                 


Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser Ser Asn Gln Lys Asn Tyr 
305                 310                 315                 320 


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
                325                 330                 335     


Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
            340                 345                 350         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala 
        355                 360                 365             


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Phe Pro Arg 
    370                 375                 380                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
            420                 425                 430         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
        435                 440                 445             


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
    450                 455                 460                 


Ala Thr Val Ser Tyr Gly Gly Ser Tyr Thr Phe Tyr Pro Asp Asn Val 
465                 470                 475                 480 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
                485                 490                 495     


Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
            500                 505                 510         


Ala Arg Asp Tyr Asp Tyr Asp Phe Phe Asp Ser Trp Gly Gln Gly Thr 
        515                 520                 525             


Thr Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    530                 535                 540                 


Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
545                 550                 555                 560 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
                565                 570                 575     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            580                 585                 590         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        595                 600                 605             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    610                 615                 620                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
625                 630                 635                 640 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                645                 650                 655     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg 
                725                 730                 735     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
            740                 745                 750         


Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
        755                 760                 765             


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
    770                 775                 780                 


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
785                 790                 795                 800 


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
                805                 810                 815     


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
            820                 825                 830         


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
        835                 840                 845             


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
    850                 855                 860                 


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
865                 870                 875                 880 


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
                885                 890                 895     


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
            900                 905                 910         


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
        915                 920                 925             


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
    930                 935                 940                 


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
945                 950                 955                 960 


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
                965                 970                 975     


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
            980                 985                 990         


Asn Ser Glu Cys Ile Gln Cys His  Pro Glu Cys Leu Pro  Gln Ala Met 
        995                 1000                 1005             


Asn Ile  Thr Cys Thr Gly Arg  Gly Pro Asp Asn Cys  Ile Gln Cys 
    1010                 1015                 1020             


Ala His  Tyr Ile Asp Gly Pro  His Cys Val Lys Thr  Cys Pro Ala 
    1025                 1030                 1035             


Gly Val  Met Gly Glu Asn Asn  Thr Leu Val Trp Lys  Tyr Ala Asp 
    1040                 1045                 1050             


Ala Gly  His Val Cys His Leu  Cys His Pro Asn Cys  Thr Tyr Gly 
    1055                 1060                 1065             


Cys Thr  Gly Pro Gly Leu Glu  Gly Cys Pro Thr Asn  Gly Pro Lys 
    1070                 1075                 1080             


Ile Pro  Ser Ile Ala Thr Gly  Met Val Gly Ala Leu  Leu Leu Leu 
    1085                 1090                 1095             


Leu Val  Val Ala Leu Gly Ile  Gly Leu Phe Met 
    1100                 1105                 


<210>  204
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  204
ggaggaggag gcagcggcgg aggaggctcc ggaggcggcg gctctggcgg cggcggcagc       60


<210>  205
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  205
ggaggaggag gcagcggagg aggaggctcc ggcggcggcg gctct                       45


<210>  206
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence as a whole repeats n times, wherein n is an integer 
       including 1, 2, 3, 4, 5, 6, 7, 8, 9 or more.

<400>  206

Gly Gly Gly Gly Ser 
1               5   


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  The first four residues of the entire sequence (GlyGlyGlySer) as 
       a whole are repeated n times, wherein n is an integer of 1, 2, 3,
       4, 5, 6, 7, 8, 9 or 10.

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  The last five residues of the entire sequence (GlyGlyGlyGlySer) 
       as a whole are repeated n times, wherein n is an integer of 1, 2,
       3, 4, 5, 6, 7, 8, 9 or 10.

<400>  207

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  The first four residues of the sequence (GlyGlyGlySer) are 
       repeated n times as a whole, wherein n is an integer of 1, 2, 3, 
       4, 5, 6, 7, 8, 9 or 10. This sequence is then followed by the 
       remaining part of the sequence.

<220>
<221>  MISC_FEATURE
<222>  (5)..(7)
<223>  The last three residues of the sequence (GlyGlySer) are repeated 
       n times as a whole, wherein n is an integer of 1, 2, 3, 4, 5, 6, 
       7, 8, 9 or 10.

<400>  208

Gly Gly Gly Ser Gly Gly Ser 
1               5           


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  The first four residues of the sequence (GlyGlyGlySer) as a whole
       are repeated n times, wherein n is an integer of 1, 2, 3, 4, 5, 
       6, 7, 8, 9 or 10. This sequence is then followed by the remaining
       residues of the sequence.

<400>  209

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  210

Gly Gly Gly Gly Ser 
1               5   


<210>  211
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  211

Gly Gly Gly Ser 
1               


<210>  212
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  212

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  213

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  214
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 binding domain VL

<400>  214

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Gln Ile Val Leu Ser Gln Ser Pro Ala 
            20                  25                  30          


Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala 
        35                  40                  45              


Ser Ser Ser Ile Asn Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser 
    50                  55                  60                  


Ser Pro Lys Pro Trp Ile Phe Ala Thr Ser Asn Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Trp Arg Ser Asp Arg Ala Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Ile Arg Ala Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  215
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 binding domain VH

<400>  215

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Arg Tyr Trp Met His Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Met Ile His Pro Ser Ser Gly Ser 
65                  70                  75                  80  


Thr Ser Tyr Asn Glu Lys Val Lys Asn Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Arg Ser Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Asp Gly Asp Tyr Tyr Tyr Gly 
        115                 120                 125             


Thr Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala 
    130                 135                 140                 


Arg Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 targeting CLL-1

<400>  216

Asp Tyr Tyr Met His 
1               5   


<210>  217
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 targeting CLL-1

<400>  217

Arg Ile Asn Pro Tyr Ala Gly Ala Ala Phe Tyr Ser Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  218
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 targeting CLL-1

<400>  218

Glu Arg Gly Ala Asp Leu Glu Gly Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  219
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDHL1 targeting CLL-1

<400>  219

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Asn Tyr Met His 
1               5                   10                  15  


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 targeting CLL-1

<400>  220

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 targeting CLL-1

<400>  221

Gln His Ser Trp Glu Ile Pro Leu Thr 
1               5                   


<210>  222
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M26 CDRL1

<400>  222

Gln Glu Leu Ser Gly Tyr 
1               5       


<210>  223
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M26 CDRL3

<400>  223

Leu Gln Tyr Ala Ile Tyr Pro Tyr Thr 
1               5                   


<210>  224
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M26 CDRH1

<400>  224

Gly Tyr Thr Phe Thr Ser Tyr Phe 
1               5               


<210>  225
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M26 CDRH2

<400>  225

Ile Asn Pro Tyr Asn Asp Gly Ser 
1               5               


<210>  226
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M26 CDRH3

<400>  226

Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M31 CDRL1

<400>  227

Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M31 CDRL3

<400>  228

Gln Gln Asn Asn Tyr Asp Pro Trp Thr 
1               5                   


<210>  229
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M31 CDRH1

<400>  229

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  230
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M31 CDRH2

<400>  230

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  231
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M31 CDRH3

<400>  231

Ala Arg Pro Ile Tyr Phe Asp Asn Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  232
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4 CDRL1

<400>  232

His Asp Ile Ser Asn Tyr 
1               5       


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4 CDRL3

<400>  233

Gln Gln Gly Lys Thr Leu Leu Trp Thr 
1               5                   


<210>  234
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4 CDRH1

<400>  234

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  235
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4 CDRH3

<400>  235

Ala Arg Thr Asp Asp Tyr Asp Asp Tyr Thr Met Asp Tyr 
1               5                   10              


<210>  236
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26292 CDRL1

<400>  236

Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala 
1               5                   10      


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26292 CDRL2

<400>  237

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26292 CDRL3

<400>  238

Gln Gln His Asn Lys Tyr Pro Tyr Thr 
1               5                   


<210>  239
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26292 CDRH1

<400>  239

Ser Tyr Trp Met Asn 
1               5   


<210>  240
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26292 CDRH2

<400>  240

Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  241
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26292 CDRH3

<400>  241

Gly Asn Trp Asp Asp Tyr 
1               5       


<210>  242
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDRL1

<400>  242

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDRL2

<400>  243

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDRL3

<400>  244

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  245
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDRH1

<400>  245

Asn Tyr Trp Met Asn 
1               5   


<210>  246
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDRH2

<400>  246

Arg Ile Asp Pro Ser Asp Ser Glu Ser His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  247
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32703 CDRH3

<400>  247

Tyr Asp Tyr Asp Asp Thr Met Asp Tyr 
1               5                   


<210>  248
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  248

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
1               5                   10                  15  


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  249

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  250

Gln Gln Ser Lys Glu Asp Pro Pro Thr 
1               5                   


<210>  251
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  251

Asn Tyr Gly Met Asn 
1               5   


<210>  252
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  252

Trp Met Asn Thr Asn Thr Gly Glu Pro Thr Ser Leu Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  253
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  253

Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
1               5                   


<210>  254
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  254

Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  255
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  255

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Val Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Ala Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  256
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain

<400>  256

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Ile Met His Trp Met Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Arg Pro Tyr Asn Asp Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ser Asp Arg Ser Ser Ser Thr Ala Asn 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Asn Asp Tyr 
            100                 


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 linker

<400>  257

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
1               5                   10      


<210>  258
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence as a whole repeats n times, wherein n is an integer 
       including 1, 2, 3, 4, 5, 6, 7, 8, 9, or more.

<400>  258

Glu Ala Ala Ala Lys 
1               5   


<210>  259
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  259

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  260
<211>  2673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental CAR T cell Vector

<400>  260

Cys Thr Cys Gly Ala Gly Ala Cys Cys Ala Thr Gly Gly Ala Gly Ala 
1               5                   10                  15      


Cys Cys Gly Ala Thr Ala Cys Ala Cys Thr Gly Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Thr Gly Gly Gly Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly 
        35                  40                  45              


Thr Gly Gly Gly Thr Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala 
    50                  55                  60                  


Cys Cys Gly Gly Cys Gly Ala Cys Ala Thr Cys Gly Thr Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Cys Ala Cys Ala Gly Ala Gly Cys Cys Cys Cys Ala Gly Cys 
                85                  90                  95      


Thr Cys Cys Cys Thr Gly Gly Cys Cys Gly Thr Gly Thr Cys Cys Gly 
            100                 105                 110         


Thr Gly Gly Gly Ala Gly Ala Gly Ala Ala Gly Gly Thr Gly Ala Cys 
        115                 120                 125             


Cys Ala Thr Gly Thr Cys Thr Thr Gly Cys Ala Ala Gly Thr Cys Thr 
    130                 135                 140                 


Ala Gly Cys Cys Ala Gly Ala Gly Cys Cys Thr Gly Cys Thr Gly Thr 
145                 150                 155                 160 


Thr Thr Thr Cys Cys Thr Cys Thr Ala Ala Cys Cys Ala Gly Ala Ala 
                165                 170                 175     


Gly Ala Ala Thr Thr Ala Cys Cys Thr Gly Gly Cys Cys Thr Gly Gly 
            180                 185                 190         


Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys Ala Gly 
        195                 200                 205             


Gly Cys Cys Ala Gly Thr Cys Cys Cys Cys Cys Ala Ala Gly Cys Thr 
    210                 215                 220                 


Gly Cys Thr Gly Ala Thr Cys Thr Ala Thr Thr Gly Gly Gly Cys Cys 
225                 230                 235                 240 


Ala Gly Cys Ala Cys Cys Ala Gly Ala Gly Ala Gly Thr Cys Cys Gly 
                245                 250                 255     


Gly Cys Gly Thr Gly Cys Cys Cys Gly Ala Thr Ala Gly Gly Thr Thr 
            260                 265                 270         


Cys Ala Cys Cys Gly Gly Cys Thr Cys Cys Gly Gly Cys Thr Cys Thr 
        275                 280                 285             


Gly Gly Cys Ala Cys Ala Gly Ala Cys Thr Thr Thr Ala Cys Cys Cys 
    290                 295                 300                 


Thr Gly Ala Cys Ala Ala Thr Cys Ala Gly Cys Thr Cys Cys Gly Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Cys Thr Gly 
                325                 330                 335     


Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Thr Thr Gly Cys Cys 
            340                 345                 350         


Ala Gly Cys Ala Gly Thr Thr Cys Thr Ala Cys Ala Gly Cys Thr Thr 
        355                 360                 365             


Thr Cys Cys Thr Ala Gly Ala Ala Cys Cys Thr Thr Cys Gly Gly Cys 
    370                 375                 380                 


Gly Gly Cys Gly Gly Cys Ala Cys Ala Ala Ala Gly Cys Thr Gly Gly 
385                 390                 395                 400 


Ala Gly Ala Thr Cys Ala Ala Gly Ala Gly Gly Gly Gly Ala Gly Gly 
                405                 410                 415     


Ala Gly Gly Ala Gly Gly Cys Ala Gly Cys Gly Gly Cys Gly Gly Ala 
            420                 425                 430         


Gly Gly Ala Gly Gly Cys Thr Cys Cys Gly Gly Ala Gly Gly Cys Gly 
        435                 440                 445             


Gly Cys Gly Gly Cys Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly Gly 
    450                 455                 460                 


Cys Gly Gly Cys Ala Gly Cys Gly Ala Gly Gly Thr Gly Cys Ala Gly 
465                 470                 475                 480 


Cys Thr Gly Gly Thr Gly Gly Ala Gly Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Gly Cys Gly Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Gly Cys Cys 
            500                 505                 510         


Cys Gly Gly Cys Gly Gly Cys Thr Cys Thr Cys Thr Gly Ala Ala Gly 
        515                 520                 525             


Cys Thr Gly Ala Gly Cys Thr Gly Thr Gly Cys Cys Gly Cys Cys Thr 
    530                 535                 540                 


Cys Cys Gly Gly Cys Thr Thr Cys Ala Cys Cys Thr Thr Thr Thr Cys 
545                 550                 555                 560 


Thr Ala Gly Cys Thr Ala Cys Gly Cys Cys Ala Thr Gly Thr Cys Thr 
                565                 570                 575     


Thr Gly Gly Gly Thr Gly Ala Gly Ala Cys Ala Gly Ala Cys Ala Cys 
            580                 585                 590         


Cys Cys Gly Ala Gly Ala Ala Gly Ala Gly Gly Cys Thr Gly Gly Ala 
        595                 600                 605             


Gly Thr Gly Gly Gly Thr Gly Gly Cys Cys Ala Cys Cys Gly Thr Gly 
    610                 615                 620                 


Thr Cys Thr Thr Ala Thr Gly Gly Cys Gly Gly Cys Ala Gly Cys Thr 
625                 630                 635                 640 


Ala Cys Ala Cys Ala Thr Thr Cys Thr Ala Thr Cys Cys Thr Gly Ala 
                645                 650                 655     


Thr Ala Ala Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys Gly Gly 
            660                 665                 670         


Thr Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly Cys Cys Gly Gly Gly 
        675                 680                 685             


Ala Cys Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Ala Cys Ala Ala 
    690                 695                 700                 


Thr Cys Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Gly Ala Thr Gly 
705                 710                 715                 720 


Thr Cys Cys Cys Ala Cys Cys Thr Gly Ala Ala Gly Thr Cys Thr Gly 
                725                 730                 735     


Ala Gly Gly Ala Thr Ala Cys Ala Gly Cys Cys Ala Thr Gly Thr Ala 
            740                 745                 750         


Cys Thr Ala Thr Thr Gly Cys Gly Cys Cys Ala Gly Ala Gly Ala Cys 
        755                 760                 765             


Thr Ala Cys Gly Ala Thr Thr Ala Thr Gly Ala Cys Thr Thr Cys Thr 
    770                 775                 780                 


Thr Thr Gly Ala Cys Ala Gly Cys Thr Gly Gly Gly Gly Cys Cys Ala 
785                 790                 795                 800 


Gly Gly Gly Cys Ala Cys Cys Ala Cys Ala Gly Thr Gly Ala Cys Ala 
                805                 810                 815     


Gly Thr Gly Thr Cys Cys Thr Cys Thr Ala Gly Cys Cys Thr Gly Ala 
            820                 825                 830         


Gly Gly Gly Ala Gly Thr Gly Cys Gly Ala Gly Cys Thr Gly Thr Ala 
        835                 840                 845             


Cys Gly Thr Gly Cys Ala Gly Ala Ala Gly Cys Ala Cys Ala Ala Thr 
    850                 855                 860                 


Ala Thr Cys Cys Ala Gly Gly Cys Cys Cys Thr Gly Cys Thr Gly Ala 
865                 870                 875                 880 


Ala Gly Gly Ala Thr Thr Cys Cys Ala Thr Cys Gly Thr Gly Cys Ala 
                885                 890                 895     


Gly Cys Thr Gly Thr Gly Cys Ala Cys Cys Gly Cys Ala Ala Gly Gly 
            900                 905                 910         


Cys Cys Thr Gly Ala Gly Ala Gly Gly Cys Cys Ala Ala Thr Gly Gly 
        915                 920                 925             


Cys Cys Thr Thr Cys Cys Thr Gly Ala Gly Gly Gly Ala Gly Thr Ala 
    930                 935                 940                 


Cys Thr Thr Thr Gly Ala Gly Ala Ala Gly Cys Thr Gly Gly Ala Gly 
945                 950                 955                 960 


Ala Ala Gly Gly Gly Ala Thr Cys Cys Thr Thr Thr Thr Gly Gly Gly 
                965                 970                 975     


Thr Gly Cys Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Gly 
            980                 985                 990         


Ala Gly Gly Cys Gly Thr Gly Cys  Thr Gly Gly Cys Cys  Thr Gly Cys 
        995                 1000                 1005             


Thr Ala  Thr Ala Gly Cys Cys  Thr Gly Cys Thr Gly  Gly Thr Gly 
    1010                 1015                 1020             


Ala Cys  Cys Gly Thr Gly Gly  Cys Cys Thr Thr Cys  Ala Thr Cys 
    1025                 1030                 1035             


Ala Thr  Cys Thr Thr Thr Thr  Gly Gly Gly Thr Gly  Ala Ala Gly 
    1040                 1045                 1050             


Ala Gly  Ala Gly Gly Cys Ala  Gly Gly Ala Ala Gly  Ala Ala Gly 
    1055                 1060                 1065             


Cys Thr  Gly Cys Thr Gly Thr  Ala Cys Ala Thr Cys  Thr Thr Cys 
    1070                 1075                 1080             


Ala Ala  Gly Cys Ala Gly Cys  Cys Thr Thr Thr Thr  Ala Thr Gly 
    1085                 1090                 1095             


Cys Gly  Cys Cys Cys Ala Gly  Thr Gly Cys Ala Gly  Ala Cys Cys 
    1100                 1105                 1110             


Ala Cys  Ala Cys Ala Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Thr 
    1115                 1120                 1125             


Gly Gly  Cys Thr Gly Cys Ala  Gly Cys Thr Gly Thr  Cys Gly Gly 
    1130                 1135                 1140             


Thr Thr  Cys Cys Cys Ala Gly  Ala Ala Gly Ala Ala  Gly Ala Gly 
    1145                 1150                 1155             


Gly Ala  Gly Gly Gly Ala Gly  Gly Ala Thr Gly Thr  Gly Ala Gly 
    1160                 1165                 1170             


Cys Thr  Gly Ala Gly Gly Gly  Thr Gly Ala Ala Gly  Thr Thr Thr 
    1175                 1180                 1185             


Ala Gly  Cys Cys Gly Gly Thr  Cys Cys Gly Cys Cys  Gly Ala Cys 
    1190                 1195                 1200             


Gly Cys  Ala Cys Cys Ala Gly  Cys Ala Thr Ala Cys  Cys Ala Gly 
    1205                 1210                 1215             


Cys Ala  Gly Gly Gly Cys Cys  Ala Gly Ala Ala Thr  Cys Ala Gly 
    1220                 1225                 1230             


Cys Thr  Gly Thr Ala Thr Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1235                 1240                 1245             


Ala Ala  Thr Cys Thr Gly Gly  Gly Cys Cys Gly Gly  Ala Gly Ala 
    1250                 1255                 1260             


Gly Ala  Gly Gly Ala Gly Thr  Ala Cys Gly Ala Thr  Gly Thr Gly 
    1265                 1270                 1275             


Cys Thr  Gly Gly Ala Cys Ala  Ala Gly Ala Gly Gly  Cys Gly Gly 
    1280                 1285                 1290             


Gly Gly  Cys Cys Gly Gly Gly  Ala Cys Cys Cys Cys  Gly Ala Gly 
    1295                 1300                 1305             


Ala Thr  Gly Gly Gly Ala Gly  Gly Cys Ala Ala Gly  Cys Cys Ala 
    1310                 1315                 1320             


Cys Gly  Gly Ala Gly Ala Ala  Ala Gly Ala Ala Cys  Cys Cys Cys 
    1325                 1330                 1335             


Cys Ala  Gly Gly Ala Gly Gly  Gly Cys Cys Thr Gly  Thr Ala Cys 
    1340                 1345                 1350             


Ala Ala  Thr Gly Ala Gly Cys  Thr Gly Cys Ala Gly  Ala Ala Gly 
    1355                 1360                 1365             


Gly Ala  Thr Ala Ala Gly Ala  Thr Gly Gly Cys Cys  Gly Ala Gly 
    1370                 1375                 1380             


Gly Cys  Cys Thr Ala Thr Thr  Cys Thr Gly Ala Gly  Ala Thr Cys 
    1385                 1390                 1395             


Gly Gly  Cys Ala Thr Gly Ala  Ala Gly Gly Gly Ala  Gly Ala Gly 
    1400                 1405                 1410             


Ala Gly  Gly Cys Gly Cys Cys  Gly Gly Gly Gly Cys  Ala Ala Gly 
    1415                 1420                 1425             


Gly Gly  Ala Cys Ala Cys Gly  Ala Cys Gly Gly Ala  Cys Thr Gly 
    1430                 1435                 1440             


Thr Ala  Cys Cys Ala Gly Gly  Gly Ala Cys Thr Gly  Ala Gly Cys 
    1445                 1450                 1455             


Ala Cys  Cys Gly Cys Ala Ala  Cys Ala Ala Ala Gly  Gly Ala Thr 
    1460                 1465                 1470             


Ala Cys  Cys Thr Ala Thr Gly  Ala Cys Gly Cys Cys  Cys Thr Gly 
    1475                 1480                 1485             


Cys Ala  Cys Ala Thr Gly Cys  Ala Gly Gly Cys Cys  Cys Thr Gly 
    1490                 1495                 1500             


Cys Cys  Cys Cys Cys Thr Cys  Gly Cys Cys Thr Gly  Gly Ala Gly 
    1505                 1510                 1515             


Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Gly Ala Gly  Gly Gly Ala 
    1520                 1525                 1530             


Ala Gly  Gly Gly Gly Cys Ala  Gly Cys Cys Thr Gly  Cys Thr Gly 
    1535                 1540                 1545             


Ala Cys  Cys Thr Gly Cys Gly  Gly Cys Gly Ala Thr  Gly Thr Gly 
    1550                 1555                 1560             


Gly Ala  Gly Gly Ala Gly Ala  Ala Cys Cys Cys Thr  Gly Gly Cys 
    1565                 1570                 1575             


Cys Cys  Ala Cys Gly Cys Ala  Thr Gly Cys Thr Gly  Cys Thr Gly 
    1580                 1585                 1590             


Cys Thr  Gly Gly Thr Gly Ala  Cys Ala Thr Cys Cys  Cys Thr Gly 
    1595                 1600                 1605             


Cys Thr  Gly Cys Thr Gly Thr  Gly Cys Gly Ala Gly  Cys Thr Gly 
    1610                 1615                 1620             


Cys Cys  Ala Cys Ala Cys Cys  Cys Thr Gly Cys Cys  Thr Thr Cys 
    1625                 1630                 1635             


Cys Thr  Gly Cys Thr Gly Ala  Thr Cys Cys Cys Ala  Cys Gly Gly 
    1640                 1645                 1650             


Ala Ala  Gly Gly Thr Gly Thr  Gly Cys Ala Ala Thr  Gly Gly Cys 
    1655                 1660                 1665             


Ala Thr  Cys Gly Gly Cys Ala  Thr Cys Gly Gly Cys  Gly Ala Gly 
    1670                 1675                 1680             


Thr Thr  Cys Ala Ala Gly Gly  Ala Cys Thr Cys Thr  Cys Thr Gly 
    1685                 1690                 1695             


Ala Gly  Cys Ala Thr Cys Ala  Ala Cys Gly Cys Cys  Ala Cys Cys 
    1700                 1705                 1710             


Ala Ala  Thr Ala Thr Cys Ala  Ala Gly Cys Ala Cys  Thr Thr Thr 
    1715                 1720                 1725             


Ala Ala  Gly Ala Ala Cys Thr  Gly Thr Ala Cys Ala  Thr Cys Cys 
    1730                 1735                 1740             


Ala Thr  Cys Thr Cys Thr Gly  Gly Cys Gly Ala Thr  Cys Thr Gly 
    1745                 1750                 1755             


Cys Ala  Cys Ala Thr Cys Cys  Thr Gly Cys Cys Thr  Gly Thr Gly 
    1760                 1765                 1770             


Gly Cys  Cys Thr Thr Cys Cys  Gly Cys Gly Gly Cys  Gly Ala Cys 
    1775                 1780                 1785             


Thr Cys  Cys Thr Thr Thr Ala  Cys Cys Cys Ala Cys  Ala Cys Ala 
    1790                 1795                 1800             


Cys Cys  Ala Cys Cys Cys Cys  Thr Gly Gly Ala Cys  Cys Cys Cys 
    1805                 1810                 1815             


Cys Ala  Gly Gly Ala Gly Cys  Thr Gly Gly Ala Cys  Ala Thr Cys 
    1820                 1825                 1830             


Cys Thr  Gly Ala Ala Gly Ala  Cys Cys Gly Thr Gly  Ala Ala Gly 
    1835                 1840                 1845             


Gly Ala  Gly Ala Thr Cys Ala  Cys Ala Gly Gly Cys  Thr Thr Cys 
    1850                 1855                 1860             


Cys Thr  Gly Cys Thr Gly Ala  Thr Cys Cys Ala Gly  Gly Cys Cys 
    1865                 1870                 1875             


Thr Gly  Gly Cys Cys Cys Gly  Ala Gly Ala Ala Cys  Cys Gly Gly 
    1880                 1885                 1890             


Ala Cys  Cys Gly Ala Thr Cys  Thr Gly Cys Ala Cys  Gly Cys Cys 
    1895                 1900                 1905             


Thr Thr  Thr Gly Ala Gly Ala  Ala Thr Cys Thr Gly  Gly Ala Gly 
    1910                 1915                 1920             


Ala Thr  Cys Ala Thr Cys Cys  Gly Gly Gly Gly Cys  Ala Gly Ala 
    1925                 1930                 1935             


Ala Cys  Ala Ala Ala Gly Cys  Ala Gly Cys Ala Cys  Gly Gly Cys 
    1940                 1945                 1950             


Cys Ala  Gly Thr Thr Cys Thr  Cys Cys Cys Thr Gly  Gly Cys Cys 
    1955                 1960                 1965             


Gly Thr  Gly Gly Thr Gly Thr  Cys Thr Cys Thr Gly  Ala Ala Cys 
    1970                 1975                 1980             


Ala Thr  Cys Ala Cys Cys Ala  Gly Cys Cys Thr Gly  Gly Gly Cys 
    1985                 1990                 1995             


Cys Thr  Gly Ala Gly Ala Thr  Cys Cys Cys Thr Gly  Ala Ala Gly 
    2000                 2005                 2010             


Gly Ala  Gly Ala Thr Cys Thr  Cys Thr Gly Ala Thr  Gly Gly Cys 
    2015                 2020                 2025             


Gly Ala  Cys Gly Thr Gly Ala  Thr Cys Ala Thr Cys  Thr Cys Cys 
    2030                 2035                 2040             


Gly Gly  Cys Ala Ala Cys Ala  Ala Gly Ala Ala Thr  Cys Thr Gly 
    2045                 2050                 2055             


Thr Gly  Cys Thr Ala Thr Gly  Cys Cys Ala Ala Cys  Ala Cys Ala 
    2060                 2065                 2070             


Ala Thr  Cys Ala Ala Thr Thr  Gly Gly Ala Ala Gly  Ala Ala Gly 
    2075                 2080                 2085             


Cys Thr  Gly Thr Thr Thr Gly  Gly Cys Ala Cys Cys  Thr Cys Thr 
    2090                 2095                 2100             


Gly Gly  Cys Cys Ala Gly Ala  Ala Gly Ala Cys Ala  Ala Ala Gly 
    2105                 2110                 2115             


Ala Thr  Cys Ala Thr Cys Thr  Cys Cys Ala Ala Cys  Ala Gly Gly 
    2120                 2125                 2130             


Gly Gly  Ala Gly Ala Gly Ala  Ala Cys Ala Gly Cys  Thr Gly Cys 
    2135                 2140                 2145             


Ala Ala  Gly Gly Cys Ala Ala  Cys Cys Gly Gly Ala  Cys Ala Gly 
    2150                 2155                 2160             


Gly Thr  Gly Thr Gly Cys Cys  Ala Cys Gly Cys Ala  Cys Thr Gly 
    2165                 2170                 2175             


Thr Gly  Cys Thr Cys Thr Cys  Cys Thr Gly Ala Gly  Gly Gly Ala 
    2180                 2185                 2190             


Thr Gly  Thr Thr Gly Gly Gly  Gly Ala Cys Cys Ala  Gly Ala Gly 
    2195                 2200                 2205             


Cys Cys  Cys Cys Gly Cys Gly  Ala Thr Thr Gly Cys  Gly Thr Gly 
    2210                 2215                 2220             


Ala Gly  Cys Thr Gly Thr Cys  Gly Gly Ala Ala Cys  Gly Thr Gly 
    2225                 2230                 2235             


Thr Cys  Cys Ala Gly Ala Gly  Gly Cys Ala Gly Gly  Gly Ala Gly 
    2240                 2245                 2250             


Thr Gly  Cys Gly Thr Gly Gly  Ala Cys Ala Ala Gly  Thr Gly Thr 
    2255                 2260                 2265             


Ala Ala  Thr Cys Thr Gly Cys  Thr Gly Gly Ala Gly  Gly Gly Cys 
    2270                 2275                 2280             


Gly Ala  Gly Cys Cys Thr Ala  Gly Ala Gly Ala Gly  Thr Thr Cys 
    2285                 2290                 2295             


Gly Thr  Gly Gly Ala Gly Ala  Ala Cys Ala Gly Cys  Gly Ala Gly 
    2300                 2305                 2310             


Thr Gly  Cys Ala Thr Cys Cys  Ala Gly Thr Gly Thr  Cys Ala Cys 
    2315                 2320                 2325             


Cys Cys  Cys Gly Ala Gly Thr  Gly Cys Cys Thr Gly  Cys Cys Thr 
    2330                 2335                 2340             


Cys Ala  Gly Gly Cys Cys Ala  Thr Gly Ala Ala Cys  Ala Thr Cys 
    2345                 2350                 2355             


Ala Cys  Cys Thr Gly Thr Ala  Cys Ala Gly Gly Cys  Ala Gly Gly 
    2360                 2365                 2370             


Gly Gly  Cys Cys Cys Ala Gly  Ala Thr Ala Ala Thr  Thr Gly Cys 
    2375                 2380                 2385             


Ala Thr  Cys Cys Ala Gly Thr  Gly Thr Gly Cys Cys  Cys Ala Cys 
    2390                 2395                 2400             


Thr Ala  Cys Ala Thr Cys Gly  Ala Cys Gly Gly Cys  Cys Cys Cys 
    2405                 2410                 2415             


Cys Ala  Cys Thr Gly Cys Gly  Thr Gly Ala Ala Gly  Ala Cys Cys 
    2420                 2425                 2430             


Thr Gly  Thr Cys Cys Thr Gly  Cys Cys Gly Gly Cys  Gly Thr Gly 
    2435                 2440                 2445             


Ala Thr  Gly Gly Gly Cys Gly  Ala Gly Ala Ala Cys  Ala Ala Thr 
    2450                 2455                 2460             


Ala Cys  Ala Cys Thr Gly Gly  Thr Gly Thr Gly Gly  Ala Ala Gly 
    2465                 2470                 2475             


Thr Ala  Cys Gly Cys Ala Gly  Ala Cys Gly Cys Ala  Gly Gly Ala 
    2480                 2485                 2490             


Cys Ala  Cys Gly Thr Gly Thr  Gly Cys Cys Ala Cys  Cys Thr Gly 
    2495                 2500                 2505             


Thr Gly  Cys Cys Ala Cys Cys  Cys Ala Ala Ala Thr  Thr Gly Cys 
    2510                 2515                 2520             


Ala Cys  Cys Thr Ala Thr Gly  Gly Cys Thr Gly Thr  Ala Cys Ala 
    2525                 2530                 2535             


Gly Gly  Cys Cys Cys Thr Gly  Gly Cys Cys Thr Gly  Gly Ala Gly 
    2540                 2545                 2550             


Gly Gly  Ala Thr Gly Thr Cys  Cys Ala Ala Cys Cys  Ala Ala Cys 
    2555                 2560                 2565             


Gly Gly  Ala Cys Cys Ala Ala  Ala Gly Ala Thr Cys  Cys Cys Thr 
    2570                 2575                 2580             


Ala Gly  Cys Ala Thr Cys Gly  Cys Ala Ala Cys Ala  Gly Gly Ala 
    2585                 2590                 2595             


Ala Thr  Gly Gly Thr Gly Gly  Gly Cys Gly Cys Cys  Cys Thr Gly 
    2600                 2605                 2610             


Cys Thr  Gly Cys Thr Gly Cys  Thr Gly Cys Thr Gly  Gly Thr Gly 
    2615                 2620                 2625             


Gly Thr  Gly Gly Cys Cys Cys  Thr Gly Gly Gly Ala  Ala Thr Cys 
    2630                 2635                 2640             


Gly Gly  Cys Cys Thr Gly Thr  Thr Cys Ala Thr Gly  Thr Ala Ala 
    2645                 2650                 2655             


Thr Gly  Cys Gly Gly Cys Cys  Gly Cys Thr Cys Thr  Ala Gly Ala 
    2660                 2665                 2670             


<210>  261
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC02357 CDRL1

<400>  261

Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5               


<210>  262
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC02357 CDRL2

<400>  262

Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210>  263
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC02357 CDRL3

<400>  263

Gln Gln Ser Tyr Ser Thr Pro Pro 
1               5               


<210>  264
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC02357 CDRH1

<400>  264

Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser 
1               5                   10  


<210>  265
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC02357 CDRH2

<400>  265

Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr 
1               5                   10              


<210>  266
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC02357 CDRH3

<400>  266

Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr 
1               5                   10  


<210>  267
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 scFv with shorter linker

<400>  267

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


