                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR TREATING PRIMARY ALDOSTERONISM

<130> 167705-016001PCT

<140> PCT/US2019/038564
<141> 2019-06-21

<150> 62/688,792
<151> 2018-06-22

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 821
<212> PRT
<213> Homo sapiens

<400> 1
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210> 2
<211> 4654
<212> DNA
<213> Homo sapiens

<400> 2
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg       60

ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta      120

cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg      180

ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg      240

tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc      300

cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt      360

ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg      420

ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag      480

gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc      540

gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa      600

cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg      660

gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct      720

tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct      780

ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga      840

aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga      900

cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct      960

atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca     1020

cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca     1080

gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc     1140

ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc     1200

caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg     1260

gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg     1320

acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc     1380

acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa     1440

atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc     1500

agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg     1560

ggctgcccta cctcaaggtt ctcaaggccg ccggtgttaa caccacggac aaagagattg     1620

aggttctcta tattcggaat gtaacttttg aggacgctgg ggaatatacg tgcttggcgg     1680

gtaattctat tgggatatcc tttcactctg catggttgac agttctgcca gcgcctggaa     1740

gagaaaagga gattacagct tccccagact acctggagat agccatttac tgcatagggg     1800

tcttcttaat cgcctgtatg gtggtaacag tcatcctgtg ccgaatgaag aacacgacca     1860

agaagccaga cttcagcagc cagccggctg tgcacaagct gaccaaacgt atccccctgc     1920

ggagacaggt aacagtttcg gctgagtcca gctcctccat gaactccaac accccgctgg     1980

tgaggataac aacacgcctc tcttcaacgg cagacacccc catgctggca ggggtctccg     2040

agtatgaact tccagaggac ccaaaatggg agtttccaag agataagctg acactgggca     2100

agcccctggg agaaggttgc tttgggcaag tggtcatggc ggaagcagtg ggaattgaca     2160

aagacaagcc caaggaggcg gtcaccgtgg ccgtgaagat gttgaaagat gatgccacag     2220

agaaagacct ttctgatctg gtgtcagaga tggagatgat gaagatgatt gggaaacaca     2280

agaatatcat aaatcttctt ggagcctgca cacaggatgg gcctctctat gtcatagttg     2340

agtatgcctc taaaggcaac ctccgagaat acctccgagc ccggaggcca cccgggatgg     2400

agtactccta tgacattaac cgtgttcctg aggagcagat gaccttcaag gacttggtgt     2460

catgcaccta ccagctggcc agaggcatgg agtacttggc ttcccaaaaa tgtattcatc     2520

gagatttagc agccagaaat gttttggtaa cagaaaacaa tgtgatgaaa atagcagact     2580

ttggactcgc cagagatatc aacaatatag actattacaa aaagaccacc aatgggcggc     2640

ttccagtcaa gtggatggct ccagaagccc tgtttgatag agtatacact catcagagtg     2700

atgtctggtc cttcggggtg ttaatgtggg agatcttcac tttagggggc tcgccctacc     2760

cagggattcc cgtggaggaa ctttttaagc tgctgaagga aggacacaga atggataagc     2820

cagccaactg caccaacgaa ctgtacatga tgatgaggga ctgttggcat gcagtgccct     2880

cccagagacc aacgttcaag cagttggtag aagacttgga tcgaattctc actctcacaa     2940

ccaatgagga atacttggac ctcagccaac ctctcgaaca gtattcacct agttaccctg     3000

acacaagaag ttcttgttct tcaggagatg attctgtttt ttctccagac cccatgcctt     3060

acgaaccatg ccttcctcag tatccacaca taaacggcag tgttaaaaca tgaatgactg     3120

tgtctgcctg tccccaaaca ggacagcact gggaacctag ctacactgag cagggagacc     3180

atgcctccca gagcttgttg tctccacttg tatatatgga tcagaggagt aaataattgg     3240

aaaagtaatc agcatatgtg taaagattta tacagttgaa aacttgtaat cttccccagg     3300

aggagaagaa ggtttctgga gcagtggact gccacaagcc accatgtaac ccctctcacc     3360

tgccgtgcgt actggctgtg gaccagtagg actcaaggtg gacgtgcgtt ctgccttcct     3420

tgttaatttt gtaataattg gagaagattt atgtcagcac acacttacag agcacaaatg     3480

cagtatatag gtgctggatg tatgtaaata tattcaaatt atgtataaat atatattata     3540

tatttacaag gagttatttt ttgtattgat tttaaatgga tgtcccaatg cacctagaaa     3600

attggtctct ctttttttaa tagctatttg ctaaatgctg ttcttacaca taatttctta     3660

attttcaccg agcagaggtg gaaaaatact tttgctttca gggaaaatgg tataacgtta     3720

atttattaat aaattggtaa tatacaaaac aattaatcat ttatagtttt ttttgtaatt     3780

taagtggcat ttctatgcag gcagcacagc agactagtta atctattgct tggacttaac     3840

tagttatcag atcctttgaa aagagaatat ttacaatata tgactaattt ggggaaaatg     3900

aagttttgat ttatttgtgt ttaaatgctg ctgtcagacg attgttctta gacctcctaa     3960

atgccccata ttaaaagaac tcattcatag gaaggtgttt cattttggtg tgcaaccctg     4020

tcattacgtc aacgcaacgt ctaactggac ttcccaagat aaatggtacc agcgtcctct     4080

taaaagatgc cttaatccat tccttgagga cagaccttag ttgaaatgat agcagaatgt     4140

gcttctctct ggcagctggc cttctgcttc tgagttgcac attaatcaga ttagcctgta     4200

ttctcttcag tgaattttga taatggcttc cagactcttt ggcgttggag acgcctgtta     4260

ggatcttcaa gtcccatcat agaaaattga aacacagagt tgttctgctg atagttttgg     4320

ggatacgtcc atctttttaa gggattgctt tcatctaatt ctggcaggac ctcaccaaaa     4380

gatccagcct catacctaca tcagacaaaa tatcgccgtt gttccttctg tactaaagta     4440

ttgtgttttg ctttggaaac acccactcac tttgcaatag ccgtgcaaga tgaatgcaga     4500

ttacactgat cttatgtgtt acaaaattgg agaaagtatt taataaaacc tgttaatttt     4560

tatactgaca ataaaaatgt ttctacagat attaatgtta acaagacaaa ataaatgtca     4620

cgcaacttat ttttttaata aaaaaaaaaa aaaa                                 4654


