                               SEQUENCE LISTING

<110> KITE PHARMA, INC.
 
<120> CHIMERIC TRANSMEMBRANE PROTEINS AND USES THEREOF

<130> CDL-700.PF - 43159-0072WO1

<140>
<141>

<150> 62/688,810
<151> 2018-06-22

<160> 111   

<170> PatentIn version 3.5

<210> 1
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1
Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu 
1               5                   10                  15      


Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210> 2
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA EKA sequence"

<400> 2
Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Glu Lys 
1               5                   10                  15      


Ala Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210> 3
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA EKA sequence"

<400> 3
cccatcctgc tgaccatcag catcctgagc ttcttcagcg tggagaaggt ggtgatcctg       60

gcctgcgtgc tgtgg                                                        75


<210> 4
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA EKV sequence"

<400> 4
Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Glu Lys 
1               5                   10                  15      


Val Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210> 5
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA EKV sequence"

<400> 5
cccatcctgc tgaccatcag catcctgagc ttcttcagcg tggagaaggt ggtgatcctg       60

gcctgcgtgc tgtgg                                                        75


<210> 6
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA CPT insert sequence"

<400> 6
Pro Ile Leu Leu Thr Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser 
1               5                   10                  15      


Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25              


<210> 7
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA CPT insert sequence"

<400> 7
cccatcctgc tgacctgccc caccatcagc atcctgagct tcttcagcgt ggccctgctg       60

gtgatcctgg cctgcgtgct gtgg                                              84


<210> 8
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA PPCL insert sequence"

<400> 8
Pro Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe 
1               5                   10                  15      


Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25                  


<210> 9
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA PPCL insert sequence"

<400> 9
cccatcctgc tgccaccctg tttaaccatc agcatcctga gcttcttcag cgtggccctg       60

ctggtgatcc tggcctgcgt gctgtgg                                           87


<210> 10
<211> 22
<212> PRT
<213> Homo sapiens

<400> 10
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210> 11
<211> 220
<212> PRT
<213> Homo sapiens

<400> 11
Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu 
1               5                   10                  15      


Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser 
            20                  25                  30          


Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Ile Thr 
        35                  40                  45              


Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu 
    50                  55                  60                  


Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe 
65                  70                  75                  80  


Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser 
                85                  90                  95      


Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala 
            100                 105                 110         


Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn Asp Phe Val 
        115                 120                 125             


Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu 
    130                 135                 140                 


Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr 
145                 150                 155                 160 


His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu 
                165                 170                 175     


Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His 
            180                 185                 190         


Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg 
        195                 200                 205             


Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
    210                 215                 220 


<210> 12
<211> 660
<212> DNA
<213> Homo sapiens

<400> 12
ggcgagagcg gctacgccca gaacggcgac ctggaggacg ccgagctgga cgactacagc       60

ttcagctgct acagccagct ggaggtgaac ggcagccagc acagcctgac ctgcgccttc      120

gaggaccccg acgtgaacat caccaacctg gagttcgaga tctgcggcgc cctggtggag      180

gtgaagtgcc tgaacttcag gaagctgcag gagatctact tcatcgagac caagaagttc      240

ctgctgatcg gcaagagcaa catctgcgtg aaggtgggcg agaagagcct gacctgcaag      300

aagatcgacc tgaccaccat cgtgaagccc gaggccccct tcgacctgag cgtggtgtac      360

agggagggcg ccaacgactt cgtggtgacc ttcaacacca gccacctgca gaagaagtac      420

gtgaaggtgc tgatgcacga cgtggcctac aggcaggaga aggacgagaa caagtggacc      480

cacgtgaacc tgagcagcac caagctgacc ctgctgcaga ggaagctgca gcccgccgcc      540

atgtacgaga tcaaggtgag gagcatcccc gaccactact tcaagggctt ctggagcgag      600

tggagcccca gctactactt caggaccccc gagatcaaca acagcagcgg cgagatggac      660


<210> 13
<211> 219
<212> PRT
<213> Mus musculus

<400> 13
Glu Ser Gly Asn Ala Gln Asp Gly Asp Leu Glu Asp Ala Asp Ala Asp 
1               5                   10                  15      


Asp His Ser Phe Trp Cys His Ser Gln Leu Glu Val Asp Gly Ser Gln 
            20                  25                  30          


His Leu Leu Thr Cys Ala Phe Asn Asp Ser Asp Ile Asn Thr Ala Asn 
        35                  40                  45              


Leu Glu Phe Gln Ile Cys Gly Ala Leu Leu Arg Val Lys Cys Leu Thr 
    50                  55                  60                  


Leu Asn Lys Leu Gln Asp Ile Tyr Phe Ile Lys Thr Ser Glu Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Ser Ser Asn Ile Cys Val Lys Leu Gly Gln Lys Asn Leu 
                85                  90                  95      


Thr Cys Lys Asn Met Ala Ile Asn Thr Ile Val Lys Ala Glu Ala Pro 
            100                 105                 110         


Ser Asp Leu Lys Val Val Tyr Arg Lys Glu Ala Asn Asp Phe Leu Val 
        115                 120                 125             


Thr Phe Asn Ala Pro His Leu Lys Lys Lys Tyr Leu Lys Lys Val Lys 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Pro Ala Arg Gly Glu Ser Asn Trp Thr His 
145                 150                 155                 160 


Val Ser Leu Phe His Thr Arg Thr Thr Ile Pro Gln Arg Lys Leu Arg 
                165                 170                 175     


Pro Lys Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro His Asn Asp 
            180                 185                 190         


Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Ser Thr Phe Glu 
        195                 200                 205             


Thr Pro Glu Pro Lys Asn Gln Gly Gly Trp Asp 
    210                 215                 


<210> 14
<211> 657
<212> DNA
<213> Mus musculus

<400> 14
gaaagtggaa atgcccagga tggagaccta gaagatgcag acgcggacga tcactccttc       60

tggtgccaca gccagttgga agtggatgga agtcaacatt tattgacttg tgcttttaat      120

gactcagaca tcaacacagc taatctggaa tttcaaatat gtggggctct tttacgagtg      180

aaatgcctaa ctcttaacaa gctgcaagat atatatttta taaagacatc agaattctta      240

ctgattggta gcagcaatat atgtgtgaag cttggacaaa agaatttaac ttgcaaaaat      300

atggctataa acacaatagt taaagccgag gctccctctg acctgaaagt cgtttatcgc      360

aaagaagcaa atgatttttt ggtgacattt aatgcacctc acttgaaaaa gaaatattta      420

aaaaaagtaa agcatgatgt ggcctaccgc ccagcaaggg gtgaaagcaa ctggacgcat      480

gtatctttat tccacacaag aacaacaatc ccacagagaa aactacgacc aaaagcaatg      540

tatgaaatca aagtccgatc cattccccat aacgattact tcaaaggctt ctggagcgag      600

tggagtccaa gttctacctt cgaaactcca gaacccaaga atcaaggagg atgggat         657


<210> 15
<211> 219
<212> PRT
<213> Mus musculus

<400> 15
Glu Ser Gly Asn Ala Gln Asp Gly Asp Leu Glu Asp Ala Asp Ala Asp 
1               5                   10                  15      


Asp His Ser Phe Trp Cys His Ser Gln Leu Glu Val Asp Gly Ser Gln 
            20                  25                  30          


His Leu Leu Thr Cys Ala Phe Asn Asp Ser Asp Ile Asn Thr Ala Asn 
        35                  40                  45              


Leu Glu Phe Gln Ile Cys Gly Ala Leu Leu Arg Val Lys Cys Leu Thr 
    50                  55                  60                  


Leu Asn Lys Leu Gln Asp Ile Tyr Phe Ile Lys Thr Ser Glu Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Ser Ser Asn Ile Cys Val Lys Leu Gly Gln Lys Asn Leu 
                85                  90                  95      


Thr Cys Lys Asn Met Ala Ile Asn Thr Ile Val Lys Ala Glu Ala Pro 
            100                 105                 110         


Ser Asp Leu Lys Val Val Tyr Arg Lys Glu Ala Asn Asp Phe Leu Val 
        115                 120                 125             


Thr Phe Asn Ala Pro His Leu Lys Lys Lys Tyr Leu Lys Lys Val Lys 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Pro Ala Arg Gly Glu Ser Asn Trp Thr His 
145                 150                 155                 160 


Val Ser Leu Phe His Thr Arg Thr Thr Ile Pro Gln Arg Lys Leu Arg 
                165                 170                 175     


Pro Lys Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro His Asn Asp 
            180                 185                 190         


Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Ser Thr Phe Glu 
        195                 200                 205             


Thr Pro Glu Pro Lys Asn Gln Gly Gly Trp Asp 
    210                 215                 


<210> 16
<211> 657
<212> DNA
<213> Mus musculus

<400> 16
gaaagtggaa atgcccagga tggagaccta gaagatgcag acgcggacga tcactccttc       60

tggtgccaca gccagttgga agtggatgga agtcaacatt tattgacttg tgcttttaat      120

gactcagaca tcaacacagc taatctggaa tttcaaatat gtggggctct tttacgagtg      180

aaatgcctaa ctcttaacaa gctgcaagat atatatttta taaagacatc agaattctta      240

ctgattggta gcagcaatat atgtgtgaag cttggacaaa agaatttaac ttgcaaaaat      300

atggctataa acacaatagt taaagccgag gctccctctg acctgaaagt cgtttatcgc      360

aaagaagcaa atgatttttt ggtgacattt aatgcacctc acttgaaaaa gaaatattta      420

aaaaaagtaa agcatgatgt ggcctaccgc ccagcaaggg gtgaaagcaa ctggacgcat      480

gtatctttat tccacacaag aacaacaatc ccacagagaa aactacgacc aaaagcaatg      540

tatgaaatca aagtccgatc cattccccat aacgattact tcaaaggctt ctggagcgag      600

tggagtccaa gttctacctt cgaaactcca gaacccaaga atcaaggagg atgggat         657


<210> 17
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane protein sequence"

<400> 17
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro 
    130                 135                 140                 


Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
145                 150                 155                 160 


Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                165                 170                 175     


Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
            180                 185                 190         


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala 
        195                 200                 205             


Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala 
225                 230                 235                 240 


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
                245                 250                 255     


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
            260                 265                 270         


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
        275                 280                 285             


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
    290                 295                 300                 


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Ile Leu Leu Thr 
305                 310                 315                 320 


Ile Ser Leu Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala 
                325                 330                 335     


Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu 
            340                 345                 350         


Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys 
        355                 360                 365             


Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
    370                 375                 380                 


His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu 
385                 390                 395                 400 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
                405                 410                 415     


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
            420                 425                 430         


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
        435                 440                 445             


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
    450                 455                 460                 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
                485                 490                 495     


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
            500                 505                 510         


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
        515                 520                 525             


Ser Ser Phe Tyr Gln Asn Gln 
    530                 535 


<210> 18
<211> 1605
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane sequence"

<400> 18
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gcagcggtgg gggctcaggc      360

ggaggaggct ctggcggagg cggaagcggg ggagggggct caggcggcgg gtccttgcag      420

attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc      480

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      540

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      600

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      660

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      720

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      780

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      840

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      900

caccagcctc caggagtgta tcctcagggc cactctgata caacacccat cctgctgacc      960

atcagcatcc tgagcttctt cagcgtggcc ctgctggtga tcctggcctg cgtgctgtgg     1020

aagaagagga tcaagcccat cgtgtggccc agcctgcccg accacaagaa gaccctggag     1080

cacctgtgta agaagcccag gaagaacctg aacgtgagct tcaaccccga gagcttcctg     1140

gactgccaga tccacagggt ggacgacatc caggccaggg acgaggtgga gggcttcctg     1200

caggacacct tcccccagca gctggaggag agcgagaagc agaggctggg cggcgacgtg     1260

cagagcccca actgccccag cgaggacgtg gtgatcaccc ccgagagctt cggcagggac     1320

agcagcctga cctgcctggc cggcaacgtg agcgcctgcg acgcccccat cctgagcagc     1380

agcaggagcc tggactgcag ggagagcggc aagaacggcc cccacgtgta ccaggacctg     1440

ctgctgagcc tgggcaccac caacagcacc ctgccacccc ccttcagcct gcagagcggc     1500

atcctgaccc tgaaccccgt ggcccagggc cagcccatcc tgaccagcct gggcagcaac     1560

caggaggagg cctacgtgac catgagcagc ttctaccaga accag                     1605


<210> 19
<211> 539
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane protein sequence"

<400> 19
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro 
    130                 135                 140                 


Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
145                 150                 155                 160 


Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                165                 170                 175     


Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
            180                 185                 190         


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala 
        195                 200                 205             


Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala 
225                 230                 235                 240 


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
                245                 250                 255     


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
            260                 265                 270         


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
        275                 280                 285             


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
    290                 295                 300                 


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Ile Leu Leu Pro 
305                 310                 315                 320 


Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                325                 330                 335     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            340                 345                 350         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        355                 360                 365             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    370                 375                 380                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
385                 390                 395                 400 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                405                 410                 415     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            420                 425                 430         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        435                 440                 445             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    450                 455                 460                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
465                 470                 475                 480 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                485                 490                 495     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            500                 505                 510         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        515                 520                 525             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    530                 535                 


<210> 20
<211> 1617
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane sequence"

<400> 20
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gcagcggtgg gggctcaggc      360

ggaggaggct ctggcggagg cggaagcggg ggagggggct caggcggcgg gtccttgcag      420

attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc      480

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      540

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      600

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      660

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      720

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      780

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      840

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      900

caccagcctc caggagtgta tcctcagggc cactctgata caacacccat cctgctgcca      960

ccctgtttaa ccatcagcat cctgagcttc ttcagcgtgg ccctgctggt gatcctggcc     1020

tgcgtgctgt ggaagaagag gatcaagccc atcgtgtggc ccagcctgcc cgaccacaag     1080

aagaccctgg agcacctgtg taagaagccc aggaagaacc tgaacgtgag cttcaacccc     1140

gagagcttcc tggactgcca gatccacagg gtggacgaca tccaggccag ggacgaggtg     1200

gagggcttcc tgcaggacac cttcccccag cagctggagg agagcgagaa gcagaggctg     1260

ggcggcgacg tgcagagccc caactgcccc agcgaggacg tggtgatcac ccccgagagc     1320

ttcggcaggg acagcagcct gacctgcctg gccggcaacg tgagcgcctg cgacgccccc     1380

atcctgagca gcagcaggag cctggactgc agggagagcg gcaagaacgg cccccacgtg     1440

taccaggacc tgctgctgag cctgggcacc accaacagca ccctgccacc ccccttcagc     1500

ctgcagagcg gcatcctgac cctgaacccc gtggcccagg gccagcccat cctgaccagc     1560

ctgggcagca accaggagga ggcctacgtg accatgagca gcttctacca gaaccag        1617


<210> 21
<211> 18
<212> PRT
<213> Homo sapiens

<400> 21
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210> 22
<211> 114
<212> PRT
<213> Homo sapiens

<400> 22
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 23
<211> 342
<212> DNA
<213> Homo sapiens

<400> 23
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttattca atctatgcat       60

attgatgcta ctttatatac ggaaagtgat gttcacccca gttgcaaagt aacagcaatg      120

aagtgctttc tcttggagtt acaagttatt tcacttgagt ccggagatgc aagtattcat      180

gatacagtag aaaatctgat catcctagca aacaacagtt tgtcttctaa tgggaatgta      240

acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa aaaatattaa agaatttttg      300

cagagttttg tacatattgt ccaaatgttc atcaacactt ct                         342


<210> 24
<211> 135
<212> PRT
<213> Homo sapiens

<400> 24
Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210> 25
<211> 408
<212> DNA
<213> Homo sapiens

<400> 25
atggtattgg gaaccataga tttgtgcagc tgtttcagtg cagggcttcc taaaacagaa       60

gccaactggg tgaatgtaat aagtgatttg aaaaaaattg aagatcttat tcaatctatg      120

catattgatg ctactttata tacggaaagt gatgttcacc ccagttgcaa agtaacagca      180

atgaagtgct ttctcttgga gttacaagtt atttcacttg agtccggaga tgcaagtatt      240

catgatacag tagaaaatct gatcatccta gcaaacaaca gtttgtcttc taatgggaat      300

gtaacagaat ctggatgcaa agaatgtgag gaactggagg aaaaaaatat taaagaattt      360

ttgcagagtt ttgtacatat tgtccaaatg ttcatcaaca cttcttga                   408


<210> 26
<211> 114
<212> PRT
<213> Mus musculus

<400> 26
Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
1               5                   10                  15      


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
    50                  55                  60                  


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
65                  70                  75                  80  


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
                85                  90                  95      


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 27
<211> 342
<212> DNA
<213> Mus musculus

<400> 27
aactggatag atgtaagata tgacctggag aaaattgaaa gccttattca atctattcat       60

attgacacca ctttatacac tgacagtgac tttcatccca gttgcaaagt tactgcaatg      120

aactgctttc tcctggaatt gcaggttatt ttacatgagt acagtaacat gactcttaat      180

gaaacagtaa gaaacgtgct ctaccttgca aacagcactc tgtcttctaa caagaatgta      240

gcagaatctg gctgcaagga atgtgaggag ctggaggaga aaaccttcac agagtttttg      300

caaagcttta tacgcattgt ccaaatgttc atcaacacgt cc                         342


<210> 28
<211> 114
<212> PRT
<213> Mus musculus

<400> 28
Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
1               5                   10                  15      


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
    50                  55                  60                  


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
65                  70                  75                  80  


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
                85                  90                  95      


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 29
<211> 342
<212> DNA
<213> Mus musculus

<400> 29
aactggatag atgtaagata tgacctggag aaaattgaaa gccttattca atctattcat       60

attgacacca ctttatacac tgacagtgac tttcatccca gttgcaaagt tactgcaatg      120

aactgctttc tcctggaatt gcaggttatt ttacatgagt acagtaacat gactcttaat      180

gaaacagtaa gaaacgtgct ctaccttgca aacagcactc tgtcttctaa caagaatgta      240

gcagaatctg gctgcaagga atgtgaggag ctggaggaga aaaccttcac agagtttttg      300

caaagcttta tacgcattgt ccaaatgttc atcaacacgt cc                         342


<210> 30
<211> 439
<212> PRT
<213> Homo sapiens

<400> 30
Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Ile Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr 
    210                 215                 220                 


Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala 
225                 230                 235                 240 


Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu 
                245                 250                 255     


Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys 
            260                 265                 270         


Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
        275                 280                 285             


His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu 
    290                 295                 300                 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
305                 310                 315                 320 


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
                325                 330                 335     


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
            340                 345                 350         


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
        355                 360                 365             


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
    370                 375                 380                 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
385                 390                 395                 400 


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
                405                 410                 415     


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
            420                 425                 430         


Ser Ser Phe Tyr Gln Asn Gln 
        435                 


<210> 31
<211> 1317
<212> DNA
<213> Homo sapiens

<400> 31
gaaagtggct atgctcaaaa tggagacttg gaagatgcag aactggatga ctactcattc       60

tcatgctata gccagttgga agtgaatgga tcgcagcact cactgacctg tgcttttgag      120

gacccagatg tcaacatcac caatctggaa tttgaaatat gtggggccct cgtggaggta      180

aagtgcctga atttcaggaa actacaagag atatatttca tcgagacaaa gaaattctta      240

ctgattggaa agagcaatat atgtgtgaag gttggagaaa agagtctaac ctgcaaaaaa      300

atagacctaa ccactatagt taaacctgag gctccttttg acctgagtgt cgtctatcgg      360

gaaggagcca atgactttgt ggtgacattt aatacatcac acttgcaaaa gaagtatgta      420

aaagttttaa tgcacgatgt agcttaccgc caggaaaagg atgaaaacaa atggacgcat      480

gtgaatttat ccagcacaaa gctgacactc ctgcagagaa agctccaacc ggcagcaatg      540

tatgagatta aagttcgatc catccctgat cactatttta aaggcttctg gagtgaatgg      600

agtccaagtt attacttcag aactccagag atcaataata gctcagggga gatggatcct      660

atcttactaa ccatcagcat tttgagtttt ttctctgtcg ctctgttggt catcttggcc      720

tgtgtgttat ggaaaaaaag gattaagcct atcgtatggc ccagtctccc cgatcataag      780

aagactctgg aacatctttg taagaaacca agaaaaaatt taaatgtgag tttcaatcct      840

gaaagtttcc tggactgcca gattcatagg gtggatgaca ttcaagctag agatgaagtg      900

gaaggttttc tgcaagatac gtttcctcag caactagaag aatctgagaa gcagaggctt      960

ggaggggatg tgcagagccc caactgccca tctgaggatg tagtcatcac tccagaaagc     1020

tttggaagag attcatccct cacatgcctg gctgggaatg tcagtgcatg tgacgcccct     1080

attctctcct cttccaggtc cctagactgc agggagagtg gcaagaatgg gcctcatgtg     1140

taccaggacc tcctgcttag ccttgggact acaaacagca cgctgccccc tccattttct     1200

ctccaatctg gaatcctgac attgaaccca gttgctcagg gtcagcccat tcttacttcc     1260

ctgggatcaa atcaagaaga agcatatgtc accatgtcca gcttctacca aaaccag        1317


<210> 32
<211> 439
<212> PRT
<213> Mus musculus

<400> 32
Glu Ser Gly Asn Ala Gln Asp Gly Asp Leu Glu Asp Ala Asp Ala Asp 
1               5                   10                  15      


Asp His Ser Phe Trp Cys His Ser Gln Leu Glu Val Asp Gly Ser Gln 
            20                  25                  30          


His Leu Leu Thr Cys Ala Phe Asn Asp Ser Asp Ile Asn Thr Ala Asn 
        35                  40                  45              


Leu Glu Phe Gln Ile Cys Gly Ala Leu Leu Arg Val Lys Cys Leu Thr 
    50                  55                  60                  


Leu Asn Lys Leu Gln Asp Ile Tyr Phe Ile Lys Thr Ser Glu Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Ser Ser Asn Ile Cys Val Lys Leu Gly Gln Lys Asn Leu 
                85                  90                  95      


Thr Cys Lys Asn Met Ala Ile Asn Thr Ile Val Lys Ala Glu Ala Pro 
            100                 105                 110         


Ser Asp Leu Lys Val Val Tyr Arg Lys Glu Ala Asn Asp Phe Leu Val 
        115                 120                 125             


Thr Phe Asn Ala Pro His Leu Lys Lys Lys Tyr Leu Lys Lys Val Lys 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Pro Ala Arg Gly Glu Ser Asn Trp Thr His 
145                 150                 155                 160 


Val Ser Leu Phe His Thr Arg Thr Thr Ile Pro Gln Arg Lys Leu Arg 
                165                 170                 175     


Pro Lys Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro His Asn Asp 
            180                 185                 190         


Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Ser Thr Phe Glu 
        195                 200                 205             


Thr Pro Glu Pro Lys Asn Gln Gly Gly Trp Asp Pro Val Leu Pro Ser 
    210                 215                 220                 


Val Thr Ile Leu Ser Leu Phe Ser Val Phe Leu Leu Val Ile Leu Ala 
225                 230                 235                 240 


His Val Leu Trp Lys Lys Arg Ile Lys Pro Val Val Trp Pro Ser Leu 
                245                 250                 255     


Pro Asp His Lys Lys Thr Leu Glu Gln Leu Cys Lys Lys Pro Lys Thr 
            260                 265                 270         


Ser Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
        275                 280                 285             


His Glu Val Lys Gly Val Glu Ala Arg Asp Glu Val Glu Ser Phe Leu 
    290                 295                 300                 


Pro Asn Asp Leu Pro Ala Gln Pro Glu Glu Leu Glu Thr Gln Gly His 
305                 310                 315                 320 


Arg Ala Ala Val His Ser Ala Asn Arg Ser Pro Glu Thr Ser Val Ser 
                325                 330                 335     


Pro Pro Glu Thr Val Arg Arg Glu Ser Pro Leu Arg Cys Leu Ala Arg 
            340                 345                 350         


Asn Leu Ser Thr Cys Asn Ala Pro Pro Leu Leu Ser Ser Arg Ser Pro 
        355                 360                 365             


Asp Tyr Arg Asp Gly Asp Arg Asn Arg Pro Pro Val Tyr Gln Asp Leu 
    370                 375                 380                 


Leu Pro Asn Ser Gly Asn Thr Asn Val Pro Val Pro Val Pro Gln Pro 
385                 390                 395                 400 


Leu Pro Phe Gln Ser Gly Ile Leu Ile Pro Val Ser Gln Arg Gln Pro 
                405                 410                 415     


Ile Ser Thr Ser Ser Val Leu Asn Gln Glu Glu Ala Tyr Val Thr Met 
            420                 425                 430         


Ser Ser Phe Tyr Gln Asn Lys 
        435                 


<210> 33
<211> 1317
<212> DNA
<213> Mus musculus

<400> 33
gaaagtggaa atgcccagga tggagaccta gaagatgcag acgcggacga tcactccttc       60

tggtgccaca gccagttgga agtggatgga agtcaacatt tattgacttg tgcttttaat      120

gactcagaca tcaacacagc taatctggaa tttcaaatat gtggggctct tttacgagtg      180

aaatgcctaa ctcttaacaa gctgcaagat atatatttta taaagacatc agaattctta      240

ctgattggta gcagcaatat atgtgtgaag cttggacaaa agaatttaac ttgcaaaaat      300

atggctataa acacaatagt taaagccgag gctccctctg acctgaaagt cgtttatcgc      360

aaagaagcaa atgatttttt ggtgacattt aatgcacctc acttgaaaaa gaaatattta      420

aaaaaagtaa agcatgatgt ggcctaccgc ccagcaaggg gtgaaagcaa ctggacgcat      480

gtatctttat tccacacaag aacaacaatc ccacagagaa aactacgacc aaaagcaatg      540

tatgaaatca aagtccgatc cattccccat aacgattact tcaaaggctt ctggagcgag      600

tggagtccaa gttctacctt cgaaactcca gaacccaaga atcaaggagg atgggatcct      660

gtcttgccaa gtgtcaccat tctgagtttg ttctctgtgt ttttgttggt catcttagcc      720

catgtgctat ggaaaaaaag gattaaacct gtcgtatggc ctagtctccc cgatcataag      780

aaaactctgg aacaactatg taagaagcca aaaacgagtc tgaatgtgag tttcaatccc      840

gaaagtttcc tggactgcca gattcatgag gtgaaaggcg ttgaagccag ggacgaggtg      900

gaaagttttc tgcccaatga tcttcctgca cagccagagg agttggagac acagggacac      960

agagccgctg tacacagtgc aaaccgctcg cctgagactt cagtcagccc accagaaaca     1020

gttagaagag agtcaccctt aagatgcctg gctagaaatc tgagtacctg caatgcccct     1080

ccactccttt cctctaggtc ccctgactac agagatggtg acagaaatag gcctcctgtg     1140

tatcaagact tgctgccaaa ctctggaaac acaaatgtcc ctgtccctgt ccctcaacca     1200

ttgcctttcc agtcgggaat cctgatacca gtttctcaga gacagcccat ctccacttcc     1260

tcagtactga atcaagaaga agcgtatgtc accatgtcta gtttttacca aaacaaa        1317


<210> 34
<211> 266
<212> PRT
<213> Mus musculus

<400> 34
Glu Ser Gly Asn Ala Gln Asp Gly Asp Leu Glu Asp Ala Asp Ala Asp 
1               5                   10                  15      


Asp His Ser Phe Trp Cys His Ser Gln Leu Glu Val Asp Gly Ser Gln 
            20                  25                  30          


His Leu Leu Thr Cys Ala Phe Asn Asp Ser Asp Ile Asn Thr Ala Asn 
        35                  40                  45              


Leu Glu Phe Gln Ile Cys Gly Ala Leu Leu Arg Val Lys Cys Leu Thr 
    50                  55                  60                  


Leu Asn Lys Leu Gln Asp Ile Tyr Phe Ile Lys Thr Ser Glu Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Ser Ser Asn Ile Cys Val Lys Leu Gly Gln Lys Asn Leu 
                85                  90                  95      


Thr Cys Lys Asn Met Ala Ile Asn Thr Ile Val Lys Ala Glu Ala Pro 
            100                 105                 110         


Ser Asp Leu Lys Val Val Tyr Arg Lys Glu Ala Asn Asp Phe Leu Val 
        115                 120                 125             


Thr Phe Asn Ala Pro His Leu Lys Lys Lys Tyr Leu Lys Lys Val Lys 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Pro Ala Arg Gly Glu Ser Asn Trp Thr His 
145                 150                 155                 160 


Val Ser Leu Phe His Thr Arg Thr Thr Ile Pro Gln Arg Lys Leu Arg 
                165                 170                 175     


Pro Lys Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro His Asn Asp 
            180                 185                 190         


Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Ser Thr Phe Glu 
        195                 200                 205             


Thr Pro Glu Pro Lys Asn Gln Gly Gly Trp Asp Pro Val Leu Pro Ser 
    210                 215                 220                 


Val Thr Ile Leu Ser Leu Phe Ser Val Phe Leu Leu Val Ile Leu Ala 
225                 230                 235                 240 


His Val Leu Trp Lys Lys Arg Ile Lys Pro Val Val Trp Pro Ser Leu 
                245                 250                 255     


Pro Asp His Lys Lys Thr Leu Glu Gln Leu 
            260                 265     


<210> 35
<211> 861
<212> DNA
<213> Mus musculus

<400> 35
atgatggctc tgggtagagc tttcgctata gttttctgct taattcaagc tgtttctgga       60

gaaagtggaa atgcccagga tggagaccta gaagatgcag acgcggacga tcactccttc      120

tggtgccaca gccagttgga agtggatgga agtcaacatt tattgacttg tgcttttaat      180

gactcagaca tcaacacagc taatctggaa tttcaaatat gtggggctct tttacgagtg      240

aaatgcctaa ctcttaacaa gctgcaagat atatatttta taaagacatc agaattctta      300

ctgattggta gcagcaatat atgtgtgaag cttggacaaa agaatttaac ttgcaaaaat      360

atggctataa acacaatagt taaagccgag gctccctctg acctgaaagt cgtttatcgc      420

aaagaagcaa atgatttttt ggtgacattt aatgcacctc acttgaaaaa gaaatattta      480

aaaaaagtaa agcatgatgt ggcctaccgc ccagcaaggg gtgaaagcaa ctggacgcat      540

gtatctttat tccacacaag aacaacaatc ccacagagaa aactacgacc aaaagcaatg      600

tatgaaatca aagtccgatc cattccccat aacgattact tcaaaggctt ctggagcgag      660

tggagtccaa gttctacctt cgaaactcca gaacccaaga atcaaggagg atgggatcct      720

gtcttgccaa gtgtcaccat tctgagtttg ttctctgtgt ttttgttggt catcttagcc      780

catgtgctat ggaaaaaaag gattaaacct gtcgtatggc ctagtctccc cgatcataag      840

aaaactctgg aacaactata g                                                861


<210> 36
<211> 62
<212> PRT
<213> Homo sapiens

<400> 36
Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
1               5                   10                  15      


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60          


<210> 37
<211> 62
<212> PRT
<213> Homo sapiens

<400> 37
Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
1               5                   10                  15      


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60          


<210> 38
<211> 62
<212> PRT
<213> Mus musculus

<400> 38
Cys Pro Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn 
1               5                   10                  15      


Tyr Ser Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60          


<210> 39
<211> 62
<212> PRT
<213> Mus musculus

<400> 39
Cys Pro Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn 
1               5                   10                  15      


Tyr Ser Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60          


<210> 40
<211> 59
<212> PRT
<213> Gallus gallus

<400> 40
Cys Pro Arg Leu Ser Thr Thr Glu Phe Ala Asp Val Ala Ala Glu Thr 
1               5                   10                  15      


Tyr Pro Leu Lys Thr Lys Leu Arg Tyr Glu Cys Asp Ser Gly Tyr Arg 
            20                  25                  30          


Arg Arg Ser Gly Asn Thr Leu Thr Ile Arg Cys Gln Asn Val Ser Gly 
        35                  40                  45              


Thr Ala Ser Trp Val His Asp Glu Leu Val Cys 
    50                  55                  


<210> 41
<211> 175
<212> PRT
<213> Homo sapiens

<400> 41
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210> 42
<211> 25
<212> PRT
<213> Mus musculus

<400> 42
Pro Val Leu Pro Ser Val Thr Ile Leu Ser Leu Phe Ser Val Phe Leu 
1               5                   10                  15      


Leu Val Ile Leu Ala His Val Leu Trp 
            20                  25  


<210> 43

<400> 43
000


<210> 44
<211> 25
<212> PRT
<213> Macaca fascicularis

<400> 44
Pro Ile Leu Leu Thr Ile Ser Leu Leu Ser Phe Phe Ser Val Ala Leu 
1               5                   10                  15      


Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210> 45
<211> 195
<212> PRT
<213> Homo sapiens

<400> 45
Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210> 46
<211> 195
<212> PRT
<213> Mus musculus

<400> 46
Lys Lys Arg Ile Lys Pro Val Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu Gln Leu Cys Lys Lys Pro Lys Thr Ser Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Glu Val Lys 
        35                  40                  45              


Gly Val Glu Ala Arg Asp Glu Val Glu Ser Phe Leu Pro Asn Asp Leu 
    50                  55                  60                  


Pro Ala Gln Pro Glu Glu Leu Glu Thr Gln Gly His Arg Ala Ala Val 
65                  70                  75                  80  


His Ser Ala Asn Arg Ser Pro Glu Thr Ser Val Ser Pro Pro Glu Thr 
                85                  90                  95      


Val Arg Arg Glu Ser Pro Leu Arg Cys Leu Ala Arg Asn Leu Ser Thr 
            100                 105                 110         


Cys Asn Ala Pro Pro Leu Leu Ser Ser Arg Ser Pro Asp Tyr Arg Asp 
        115                 120                 125             


Gly Asp Arg Asn Arg Pro Pro Val Tyr Gln Asp Leu Leu Pro Asn Ser 
    130                 135                 140                 


Gly Asn Thr Asn Val Pro Val Pro Val Pro Gln Pro Leu Pro Phe Gln 
145                 150                 155                 160 


Ser Gly Ile Leu Ile Pro Val Ser Gln Arg Gln Pro Ile Ser Thr Ser 
                165                 170                 175     


Ser Val Leu Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Lys 
        195 


<210> 47
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 47
Ser Gly Gly Ser 
1               


<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 48
Ser Gly Gly Gly Ser 
1               5   


<210> 49
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 49
Ser Gly Gly Gly Gly Ser 
1               5       


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 50
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210> 51
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 51
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly 
            


<210> 52
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 52
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 53
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 53
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser 
            20              


<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 54
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 55
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 55
ggcagcacca gcggcagcgg caaaccgggc agcggcgaag gcagcaccaa aggc             54


<210> 56
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 57
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 57
ggcggtggtg gttctggagg cggtggcagc ggtggaggtg gctcaggagg aggaggtagc       60

ggcggcggag ggagt                                                        75


<210> 58
<211> 233
<212> PRT
<213> Homo sapiens

<400> 58
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Trp Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210> 59
<211> 46
<212> PRT
<213> Homo sapiens

<400> 59
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210> 60
<211> 20
<212> PRT
<213> Homo sapiens

<400> 60
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210> 61
<211> 220
<212> PRT
<213> Homo sapiens

<400> 61
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 62
<211> 164
<212> PRT
<213> Homo sapiens

<400> 62
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210> 63
<211> 23
<212> PRT
<213> Homo sapiens

<400> 63
Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210> 64
<211> 26
<212> PRT
<213> Homo sapiens

<400> 64
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210> 65
<211> 25
<212> PRT
<213> Homo sapiens

<400> 65
Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210> 66
<211> 23
<212> PRT
<213> Homo sapiens

<400> 66
Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210> 67
<211> 26
<212> PRT
<213> Homo sapiens

<400> 67
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210> 68
<211> 24
<212> PRT
<213> Homo sapiens

<400> 68
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210> 69
<211> 24
<212> PRT
<213> Homo sapiens

<400> 69
Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210> 70
<211> 220
<212> PRT
<213> Homo sapiens

<400> 70
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 71
<211> 255
<212> PRT
<213> Homo sapiens

<400> 71
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210> 72
<211> 164
<212> PRT
<213> Homo sapiens

<400> 72
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210> 73
<211> 113
<212> PRT
<213> Homo sapiens

<400> 73
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 74
<211> 339
<212> DNA
<213> Homo sapiens

<400> 74
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgc                             339


<210> 75
<211> 233
<212> PRT
<213> Homo sapiens

<400> 75
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Trp Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210> 76
<211> 46
<212> PRT
<213> Homo sapiens

<400> 76
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210> 77
<211> 20
<212> PRT
<213> Homo sapiens

<400> 77
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210> 78
<211> 17
<212> DNA
<213> Homo sapiens

<400> 78
aaataaaata cgaaatg                                                      17


<210> 79
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA MCP insert sequence"

<400> 79
Pro Ile Leu Leu Thr Met Cys Pro Ile Ser Ile Leu Ser Phe Phe Ser 
1               5                   10                  15      


Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25              


<210> 80
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA MCP insert sequence"

<400> 80
cccatcctgc tgaccatgtg ccccatcagc atcctgagct tcttcagcgt ggccctgctg       60

gtgatcctgg cctgcgtgct gtgg                                              84


<210> 81
<211> 66
<212> DNA
<213> Homo sapiens

<400> 81
atgctcctgc tcgtgacttc acttcttctc tgtgaactcc cacaccccgc gtttttgctt       60

atccct                                                                  66


<210> 82
<211> 586
<212> DNA
<213> Homo sapiens

<400> 82
aagaagagga tcaagcccat cgtgtggccc agcctgcccg accacaagaa gaccctggag       60

cacctgtgta agaagcccag gaagaacctg aacgtgagct tcaaccccga gagcttcctg      120

gactgccaga tccacagggt ggacgacatc caggccaggg acgaggtgga gggcttcctg      180

caggacacct tcccccagca gctggaggag agcgagaagc agaggctggg cggcgacgtg      240

cagagcccca actgccccag cgaggacgtg gtgatcaccc ccgagagctt cggcagggac      300

agcagcctga cctgcctggc cggcaacgtg agcgcctgcg acgcccccat cctgagcagc      360

agcaggagcc tggactgcag ggagagcggc aagaacggcc cccacgtgta ccaggacctg      420

ctgctgagcc tgggcaccac caacagcacc ctgccacccc ccttcagcct gcagagcggc      480

atcctgaccc tgaaccccgt ggcccagggc cagcccatcc tgaccagcct gggcagcaac      540

caggaggagg cctacgtgac catgagcagc ttctaccaga accags                     586


<210> 83
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane protein sequence"

<400> 83
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro 
    130                 135                 140                 


Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
145                 150                 155                 160 


Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                165                 170                 175     


Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
            180                 185                 190         


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala 
        195                 200                 205             


Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala 
225                 230                 235                 240 


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
                245                 250                 255     


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
            260                 265                 270         


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
        275                 280                 285             


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
    290                 295                 300                 


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Ile Leu Leu Thr 
305                 310                 315                 320 


Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val 
                325                 330                 335     


Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp 
            340                 345                 350         


Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys 
        355                 360                 365             


Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp 
    370                 375                 380                 


Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu 
385                 390                 395                 400 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                405                 410                 415     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            420                 425                 430         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        435                 440                 445             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    450                 455                 460                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
465                 470                 475                 480 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                485                 490                 495     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            500                 505                 510         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        515                 520                 525             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    530                 535             


<210> 84
<211> 1614
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane sequence"

<400> 84
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gcagcggtgg gggctcaggc      360

ggaggaggct ctggcggagg cggaagcggg ggagggggct caggcggcgg gtccttgcag      420

attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc      480

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      540

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      600

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      660

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      720

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      780

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      840

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      900

caccagcctc caggagtgta tcctcagggc cactctgata caacacccat cctgctgacc      960

tgccccacca tcagcatcct gagcttcttc agcgtggccc tgctggtgat cctggcctgc     1020

gtgctgtgga agaagaggat caagcccatc gtgtggccca gcctgcccga ccacaagaag     1080

accctggagc acctgtgtaa gaagcccagg aagaacctga acgtgagctt caaccccgag     1140

agcttcctgg actgccagat ccacagggtg gacgacatcc aggccaggga cgaggtggag     1200

ggcttcctgc aggacacctt cccccagcag ctggaggaga gcgagaagca gaggctgggc     1260

ggcgacgtgc agagccccaa ctgccccagc gaggacgtgg tgatcacccc cgagagcttc     1320

ggcagggaca gcagcctgac ctgcctggcc ggcaacgtga gcgcctgcga cgcccccatc     1380

ctgagcagca gcaggagcct ggactgcagg gagagcggca agaacggccc ccacgtgtac     1440

caggacctgc tgctgagcct gggcaccacc aacagcaccc tgccaccccc cttcagcctg     1500

cagagcggca tcctgaccct gaaccccgtg gcccagggcc agcccatcct gaccagcctg     1560

ggcagcaacc aggaggaggc ctacgtgacc atgagcagct tctaccagaa ccag           1614


<210> 85
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane protein sequence"

<400> 85
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro 
    130                 135                 140                 


Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
145                 150                 155                 160 


Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                165                 170                 175     


Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
            180                 185                 190         


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala 
        195                 200                 205             


Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala 
225                 230                 235                 240 


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
                245                 250                 255     


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
            260                 265                 270         


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
        275                 280                 285             


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
    290                 295                 300                 


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Ile Leu Leu Met 
305                 310                 315                 320 


Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val 
                325                 330                 335     


Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp 
            340                 345                 350         


Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys 
        355                 360                 365             


Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp 
    370                 375                 380                 


Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu 
385                 390                 395                 400 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                405                 410                 415     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            420                 425                 430         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        435                 440                 445             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    450                 455                 460                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
465                 470                 475                 480 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                485                 490                 495     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            500                 505                 510         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        515                 520                 525             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    530                 535             


<210> 86
<211> 1614
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane sequence"

<400> 86
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gcagcggtgg gggctcaggc      360

ggaggaggct ctggcggagg cggaagcggg ggagggggct caggcggcgg gtccttgcag      420

attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc      480

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      540

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      600

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      660

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      720

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      780

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      840

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      900

caccagcctc caggagtgta tcctcagggc cactctgata caacacccat cctgctgatg      960

tgccccacca tcagcatcct gagcttcttc agcgtggccc tgctggtgat cctggcctgc     1020

gtgctgtgga agaagaggat caagcccatc gtgtggccca gcctgcccga ccacaagaag     1080

accctggagc acctgtgtaa gaagcccagg aagaacctga acgtgagctt caaccccgag     1140

agcttcctgg actgccagat ccacagggtg gacgacatcc aggccaggga cgaggtggag     1200

ggcttcctgc aggacacctt cccccagcag ctggaggaga gcgagaagca gaggctgggc     1260

ggcgacgtgc agagccccaa ctgccccagc gaggacgtgg tgatcacccc cgagagcttc     1320

ggcagggaca gcagcctgac ctgcctggcc ggcaacgtga gcgcctgcga cgcccccatc     1380

ctgagcagca gcaggagcct ggactgcagg gagagcggca agaacggccc ccacgtgtac     1440

caggacctgc tgctgagcct gggcaccacc aacagcaccc tgccaccccc cttcagcctg     1500

cagagcggca tcctgaccct gaaccccgtg gcccagggcc agcccatcct gaccagcctg     1560

ggcagcaacc aggaggaggc ctacgtgacc atgagcagct tctaccagaa ccag           1614


<210> 87
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane protein sequence"

<400> 87
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro 
    130                 135                 140                 


Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
145                 150                 155                 160 


Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                165                 170                 175     


Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
            180                 185                 190         


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala 
        195                 200                 205             


Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala 
225                 230                 235                 240 


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
                245                 250                 255     


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
            260                 265                 270         


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
        275                 280                 285             


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
    290                 295                 300                 


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Ile Leu Leu Thr 
305                 310                 315                 320 


Ile Ser Ile Leu Ser Phe Phe Ser Val Glu Lys Ala Val Ile Leu Ala 
                325                 330                 335     


Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu 
            340                 345                 350         


Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys 
        355                 360                 365             


Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
    370                 375                 380                 


His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu 
385                 390                 395                 400 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
                405                 410                 415     


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
            420                 425                 430         


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
        435                 440                 445             


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
    450                 455                 460                 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
                485                 490                 495     


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
            500                 505                 510         


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
        515                 520                 525             


Ser Ser Phe Tyr Gln Asn Gln 
    530                 535 


<210> 88
<211> 1605
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane sequence"

<400> 88
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gcagcggtgg gggctcaggc      360

ggaggaggct ctggcggagg cggaagcggg ggagggggct caggcggcgg gtccttgcag      420

attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc      480

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      540

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      600

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      660

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      720

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      780

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      840

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      900

caccagcctc caggagtgta tcctcagggc cactctgata caacacccat cctgctgacc      960

atcagcatcc tgagcttctt cagcgtggag aaggccgtga tcctggcctg cgtgctgtgg     1020

aagaagagga tcaagcccat cgtgtggccc agcctgcccg accacaagaa gaccctggag     1080

cacctgtgta agaagcccag gaagaacctg aacgtgagct tcaaccccga gagcttcctg     1140

gactgccaga tccacagggt ggacgacatc caggccaggg acgaggtgga gggcttcctg     1200

caggacacct tcccccagca gctggaggag agcgagaagc agaggctggg cggcgacgtg     1260

cagagcccca actgccccag cgaggacgtg gtgatcaccc ccgagagctt cggcagggac     1320

agcagcctga cctgcctggc cggcaacgtg agcgcctgcg acgcccccat cctgagcagc     1380

agcaggagcc tggactgcag ggagagcggc aagaacggcc cccacgtgta ccaggacctg     1440

ctgctgagcc tgggcaccac caacagcacc ctgccacccc ccttcagcct gcagagcggc     1500

atcctgaccc tgaaccccgt ggcccagggc cagcccatcc tgaccagcct gggcagcaac     1560

caggaggagg cctacgtgac catgagcagc ttctaccaga accag                     1605


<210> 89
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane protein sequence"

<400> 89
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro 
    130                 135                 140                 


Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
145                 150                 155                 160 


Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                165                 170                 175     


Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
            180                 185                 190         


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala 
        195                 200                 205             


Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala 
225                 230                 235                 240 


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
                245                 250                 255     


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
            260                 265                 270         


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
        275                 280                 285             


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
    290                 295                 300                 


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Ile Leu Leu Thr 
305                 310                 315                 320 


Ile Ser Ile Leu Ser Phe Phe Ser Val Glu Lys Val Val Ile Leu Ala 
                325                 330                 335     


Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu 
            340                 345                 350         


Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys 
        355                 360                 365             


Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile 
    370                 375                 380                 


His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu 
385                 390                 395                 400 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
                405                 410                 415     


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
            420                 425                 430         


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
        435                 440                 445             


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
    450                 455                 460                 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
                485                 490                 495     


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
            500                 505                 510         


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
        515                 520                 525             


Ser Ser Phe Tyr Gln Asn Gln 
    530                 535 


<210> 90
<211> 1605
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Exemplary chimeric transmembrane sequence"

<400> 90
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gcagcggtgg gggctcaggc      360

ggaggaggct ctggcggagg cggaagcggg ggagggggct caggcggcgg gtccttgcag      420

attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc      480

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      540

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      600

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      660

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      720

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      780

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      840

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      900

caccagcctc caggagtgta tcctcagggc cactctgata caacacccat cctgctgacc      960

atcagcatcc tgagcttctt cagcgtggag aaggtggtga tcctggcctg cgtgctgtgg     1020

aagaagagga tcaagcccat cgtgtggccc agcctgcccg accacaagaa gaccctggag     1080

cacctgtgta agaagcccag gaagaacctg aacgtgagct tcaaccccga gagcttcctg     1140

gactgccaga tccacagggt ggacgacatc caggccaggg acgaggtgga gggcttcctg     1200

caggacacct tcccccagca gctggaggag agcgagaagc agaggctggg cggcgacgtg     1260

cagagcccca actgccccag cgaggacgtg gtgatcaccc ccgagagctt cggcagggac     1320

agcagcctga cctgcctggc cggcaacgtg agcgcctgcg acgcccccat cctgagcagc     1380

agcaggagcc tggactgcag ggagagcggc aagaacggcc cccacgtgta ccaggacctg     1440

ctgctgagcc tgggcaccac caacagcacc ctgccacccc ccttcagcct gcagagcggc     1500

atcctgaccc tgaaccccgt ggcccagggc cagcccatcc tgaccagcct gggcagcaac     1560

caggaggagg cctacgtgac catgagcagc ttctaccaga accag                     1605


<210> 91
<211> 54
<212> DNA
<213> Homo sapiens 

<400> 91
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagc             54


<210> 92
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 92
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
            20                  25      


<210> 93
<211> 22
<212> PRT
<213> Homo sapiens

<400> 93
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210> 94
<211> 66
<212> DNA
<213> Homo sapiens

<400> 94
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

attcct                                                                  66


<210> 95
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD19 scFv sequence"

<400> 95
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 96
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD19 scFv sequence"

<400> 96
gacatccaga tgacccagac caccagcagc ctgagcgcca gcctgggcga tagagtgacc       60

atcagctgca gagccagcca ggacatcagc aagtacctga actggtatca gcagaaaccc      120

gacggcaccg tgaagctgct gatctaccac accagcagac tgcacagcgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag      240

gaagatatcg ctacctactt ctgtcagcaa ggcaacaccc tgccctacac cttcggcgga      300

ggcaccaagc tggaaatcac aggcggcgga ggatctggcg gaggcggaag tggcggaggg      360

ggatctgaag tgaaactgca ggaaagcggc cctggcctgg tggccccatc tcagtctctg      420

agcgtgacct gtaccgtgtc cggcgtgtcc ctgcctgact atggcgtgtc ctggatcaga      480

cagcccccca gaaagggcct ggaatggctg ggagtgatct ggggcagcga gacaacctac      540

tacaacagcg ccctgaagtc ccggctgacc atcatcaagg acaactccaa gagccaggtg      600

ttcctgaaga tgaacagcct gcagaccgac gacaccgcca tctactactg cgccaagcac      660

tactactacg gcggcagcta cgccatggac tactggggcc agggcacaag cgtgaccgtg      720

tctagc                                                                 726


<210> 97
<211> 57
<212> PRT
<213> Homo sapiens

<400> 97
Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 
1               5                   10                  15      


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
            20                  25                  30          


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        35                  40                  45              


Thr Val Ala Phe Ile Ile Phe Trp Val 
    50                  55          


<210> 98
<211> 171
<212> DNA
<213> Homo sapiens

<400> 98
ctagacaatg agaagagcaa tggaaccatt atccatgtga aagggaaaca cctttgtcca       60

agtcccctat ttcccggacc ttctaagccc ttttgggtgc tggtggtggt tggtggagtc      120

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt g               171


<210> 99
<211> 123
<212> DNA
<213> Homo sapiens

<400> 99
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210> 100
<211> 1396
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR DNA sequence"

<400> 100
gaacagaagc tgataagtga ggaggacttg gacatccaga tgacccagac caccagcagc       60

ctgagcgcca gcctgggcga tagagtgacc atcagctgca gagccagcca ggacatcagc      120

aagtacctga actggtatca gcagaaaccc gacggcaccg tgaagctgct gatctaccac      180

accagcagac tgcacagcgg cgtgcccagc agattttctg gcagcggctc cggcaccgac      240

tacagcctga ccatctccaa cctggaacag gaagatatcg ctacctactt ctgtcagcaa      300

ggcaacaccc tgccctacac cttcggcgga ggcaccaagc tggaaatcac aggcggcgga      360

ggatctggcg gaggcggaag tggcggaggg ggatctgaag tgaaactgca ggaaagcggc      420

cctggcctgg tggccccatc tcagtctctg agcgtgacct gtaccgtgtc cggcgtgtcc      480

ctgcctgact atggcgtgtc ctggatcaga cagcccccca gaaagggcct ggaatggctg      540

ggagtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc ccggctgacc      600

atcatcaagg acaactccaa gagccaggtg ttcctgaaga tgaacagcct gcagaccgac      660

gacaccgcca tctactactg cgccaagcac tactactacg gcggcagcta cgccatggac      720

tactggggcc agggcacaag cgtgaccgtg tctagcgggt ccctagacaa tgagaagagc      780

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctga gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgct                                                     1396


<210> 101
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR DNA sequence"

<400> 101
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Ile Gln Met Thr Gln 
1               5                   10                  15      


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
            20                  25                  30          


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
        35                  40                  45              


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
    50                  55                  60                  


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
65                  70                  75                  80  


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
                85                  90                  95      


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
145                 150                 155                 160 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                165                 170                 175     


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        195                 200                 205             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Ser Leu Asp 
                245                 250                 255     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210> 102
<211> 2928
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR + IL7A_CPT sequence"

<400> 102
gaacagaagc tgataagtga ggaggacttg gacatccaga tgacccagac caccagcagc       60

ctgagcgcca gcctgggcga tagagtgacc atcagctgca gagccagcca ggacatcagc      120

aagtacctga actggtatca gcagaaaccc gacggcaccg tgaagctgct gatctaccac      180

accagcagac tgcacagcgg cgtgcccagc agattttctg gcagcggctc cggcaccgac      240

tacagcctga ccatctccaa cctggaacag gaagatatcg ctacctactt ctgtcagcaa      300

ggcaacaccc tgccctacac cttcggcgga ggcaccaagc tggaaatcac aggcggcgga      360

ggatctggcg gaggcggaag tggcggaggg ggatctgaag tgaaactgca ggaaagcggc      420

cctggcctgg tggccccatc tcagtctctg agcgtgacct gtaccgtgtc cggcgtgtcc      480

ctgcctgact atggcgtgtc ctggatcaga cagcccccca gaaagggcct ggaatggctg      540

ggagtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc ccggctgacc      600

atcatcaagg acaactccaa gagccaggtg ttcctgaaga tgaacagcct gcagaccgac      660

gacaccgcca tctactactg cgccaagcac tactactacg gcggcagcta cgccatggac      720

tactggggcc agggcacaag cgtgaccgtg tctagcgggt ccctagacaa tgagaagagc      780

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctga gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgccggaa gagaagaggc aagcccatcc ccaacccact gctgggcctg     1440

gatagcacct ccggaagcgg agagggcaga ggctctctgc tgacctgcgg cgacgtggaa     1500

gagaacccag ggcccatgct cctgctcgtg acttcacttc ttctctgtga actcccacac     1560

cccgcgtttt tgcttatccc tcatcatcac catcaccacg gcgagagcgg ctacgcccag     1620

aacggcgacc tggaggacgc cgagctggac gactacagct tcagctgcta cagccagctg     1680

gaggtgaacg gcagccagca cagcctgacc tgcgccttcg aggaccccga cgtgaacatc     1740

accaacctgg agttcgagat ctgcggcgcc ctggtggagg tgaagtgcct gaacttcagg     1800

aagctgcagg agatctactt catcgagacc aagaagttcc tgctgatcgg caagagcaac     1860

atctgcgtga aggtgggcga gaagagcctg acctgcaaga agatcgacct gaccaccatc     1920

gtgaagcccg aggccccctt cgacctgagc gtggtgtaca gggagggcgc caacgacttc     1980

gtggtgacct tcaacaccag ccacctgcag aagaagtacg tgaaggtgct gatgcacgac     2040

gtggcctaca ggcaggagaa ggacgagaac aagtggaccc acgtgaacct gagcagcacc     2100

aagctgaccc tgctgcagag gaagctgcag cccgccgcca tgtacgagat caaggtgagg     2160

agcatccccg accactactt caagggcttc tggagcgagt ggagccccag ctactacttc     2220

aggacccccg agatcaacaa cagcagcggc gagatggacc ccatcctgct gacctgcccc     2280

accatcagca tcctgagctt cttcagcgtg gccctgctgg tgatcctggc ctgcgtgctg     2340

tggaagaaga ggatcaagcc catcgtgtgg cccagcctgc ccgaccacaa gaagaccctg     2400

gagcacctgt gtaagaagcc caggaagaac ctgaacgtga gcttcaaccc cgagagcttc     2460

ctggactgcc agatccacag ggtggacgac atccaggcca gggacgaggt ggagggcttc     2520

ctgcaggaca ccttccccca gcagctggag gagagcgaga agcagaggct gggcggcgac     2580

gtgcagagcc ccaactgccc cagcgaggac gtggtgatca cccccgagag cttcggcagg     2640

gacagcagcc tgacctgcct ggccggcaac gtgagcgcct gcgacgcccc catcctgagc     2700

agcagcagga gcctggactg cagggagagc ggcaagaacg gcccccacgt gtaccaggac     2760

ctgctgctga gcctgggcac caccaacagc accctgccac cccccttcag cctgcagagc     2820

ggcatcctga ccctgaaccc cgtggcccag ggccagccca tcctgaccag cctgggcagc     2880

aaccaggagg aggcctacgt gaccatgagc agcttctacc agaaccag                  2928


<210> 103
<211> 976
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR + IL7A_CPT sequence"

<400> 103
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Ile Gln Met Thr Gln 
1               5                   10                  15      


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
            20                  25                  30          


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
        35                  40                  45              


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
    50                  55                  60                  


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
65                  70                  75                  80  


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
                85                  90                  95      


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
145                 150                 155                 160 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                165                 170                 175     


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        195                 200                 205             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Ser Leu Asp 
                245                 250                 255     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Arg Lys Arg Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
465                 470                 475                 480 


Asp Ser Thr Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser 
            500                 505                 510         


Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro His 
        515                 520                 525             


His His His His His Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu 
    530                 535                 540                 


Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu 
545                 550                 555                 560 


Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro 
                565                 570                 575     


Asp Val Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val 
            580                 585                 590         


Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile 
        595                 600                 605             


Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys 
    610                 615                 620                 


Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile 
625                 630                 635                 640 


Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly 
                645                 650                 655     


Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys 
            660                 665                 670         


Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp 
        675                 680                 685             


Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu 
    690                 695                 700                 


Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg 
705                 710                 715                 720 


Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro 
                725                 730                 735     


Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met 
            740                 745                 750         


Asp Pro Ile Leu Leu Thr Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe 
        755                 760                 765             


Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg 
    770                 775                 780                 


Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu 
785                 790                 795                 800 


Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn 
                805                 810                 815     


Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
            820                 825                 830         


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
        835                 840                 845             


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
    850                 855                 860                 


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
865                 870                 875                 880 


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
                885                 890                 895     


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
            900                 905                 910         


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
        915                 920                 925             


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
    930                 935                 940                 


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
945                 950                 955                 960 


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                965                 970                 975     


<210> 104
<211> 2928
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR + IL7RaMCP sequence"

<400> 104
gaacagaagc tgataagtga ggaggacttg gacatccaga tgacccagac caccagcagc       60

ctgagcgcca gcctgggcga tagagtgacc atcagctgca gagccagcca ggacatcagc      120

aagtacctga actggtatca gcagaaaccc gacggcaccg tgaagctgct gatctaccac      180

accagcagac tgcacagcgg cgtgcccagc agattttctg gcagcggctc cggcaccgac      240

tacagcctga ccatctccaa cctggaacag gaagatatcg ctacctactt ctgtcagcaa      300

ggcaacaccc tgccctacac cttcggcgga ggcaccaagc tggaaatcac aggcggcgga      360

ggatctggcg gaggcggaag tggcggaggg ggatctgaag tgaaactgca ggaaagcggc      420

cctggcctgg tggccccatc tcagtctctg agcgtgacct gtaccgtgtc cggcgtgtcc      480

ctgcctgact atggcgtgtc ctggatcaga cagcccccca gaaagggcct ggaatggctg      540

ggagtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc ccggctgacc      600

atcatcaagg acaactccaa gagccaggtg ttcctgaaga tgaacagcct gcagaccgac      660

gacaccgcca tctactactg cgccaagcac tactactacg gcggcagcta cgccatggac      720

tactggggcc agggcacaag cgtgaccgtg tctagcgggt ccctagacaa tgagaagagc      780

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctga gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgccggaa gagaagaggc aagcccatcc ccaacccact gctgggcctg     1440

gatagcacct ccggaagcgg agagggcaga ggctctctgc tgacctgcgg cgacgtggaa     1500

gagaacccag ggcccatgct cctgctcgtg acttcacttc ttctctgtga actcccacac     1560

cccgcgtttt tgcttatccc tcatcatcac catcaccacg gcgagagcgg ctacgcccag     1620

aacggcgacc tggaggacgc cgagctggac gactacagct tcagctgcta cagccagctg     1680

gaggtgaacg gcagccagca cagcctgacc tgcgccttcg aggaccccga cgtgaacatc     1740

accaacctgg agttcgagat ctgcggcgcc ctggtggagg tgaagtgcct gaacttcagg     1800

aagctgcagg agatctactt catcgagacc aagaagttcc tgctgatcgg caagagcaac     1860

atctgcgtga aggtgggcga gaagagcctg acctgcaaga agatcgacct gaccaccatc     1920

gtgaagcccg aggccccctt cgacctgagc gtggtgtaca gggagggcgc caacgacttc     1980

gtggtgacct tcaacaccag ccacctgcag aagaagtacg tgaaggtgct gatgcacgac     2040

gtggcctaca ggcaggagaa ggacgagaac aagtggaccc acgtgaacct gagcagcacc     2100

aagctgaccc tgctgcagag gaagctgcag cccgccgcca tgtacgagat caaggtgagg     2160

agcatccccg accactactt caagggcttc tggagcgagt ggagccccag ctactacttc     2220

aggacccccg agatcaacaa cagcagcggc gagatggacc ccatcctgct gatgtgcccc     2280

accatcagca tcctgagctt cttcagcgtg gccctgctgg tgatcctggc ctgcgtgctg     2340

tggaagaaga ggatcaagcc catcgtgtgg cccagcctgc ccgaccacaa gaagaccctg     2400

gagcacctgt gtaagaagcc caggaagaac ctgaacgtga gcttcaaccc cgagagcttc     2460

ctggactgcc agatccacag ggtggacgac atccaggcca gggacgaggt ggagggcttc     2520

ctgcaggaca ccttccccca gcagctggag gagagcgaga agcagaggct gggcggcgac     2580

gtgcagagcc ccaactgccc cagcgaggac gtggtgatca cccccgagag cttcggcagg     2640

gacagcagcc tgacctgcct ggccggcaac gtgagcgcct gcgacgcccc catcctgagc     2700

agcagcagga gcctggactg cagggagagc ggcaagaacg gcccccacgt gtaccaggac     2760

ctgctgctga gcctgggcac caccaacagc accctgccac cccccttcag cctgcagagc     2820

ggcatcctga ccctgaaccc cgtggcccag ggccagccca tcctgaccag cctgggcagc     2880

aaccaggagg aggcctacgt gaccatgagc agcttctacc agaaccag                  2928


<210> 105
<211> 976
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR + IL7RaMCP sequence"

<400> 105
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Ile Gln Met Thr Gln 
1               5                   10                  15      


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
            20                  25                  30          


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
        35                  40                  45              


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
    50                  55                  60                  


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
65                  70                  75                  80  


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
                85                  90                  95      


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
145                 150                 155                 160 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                165                 170                 175     


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        195                 200                 205             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Ser Leu Asp 
                245                 250                 255     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Arg Lys Arg Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
465                 470                 475                 480 


Asp Ser Thr Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser 
            500                 505                 510         


Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro His 
        515                 520                 525             


His His His His His Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu 
    530                 535                 540                 


Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu 
545                 550                 555                 560 


Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro 
                565                 570                 575     


Asp Val Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val 
            580                 585                 590         


Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile 
        595                 600                 605             


Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys 
    610                 615                 620                 


Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile 
625                 630                 635                 640 


Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly 
                645                 650                 655     


Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys 
            660                 665                 670         


Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp 
        675                 680                 685             


Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu 
    690                 695                 700                 


Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg 
705                 710                 715                 720 


Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro 
                725                 730                 735     


Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met 
            740                 745                 750         


Asp Pro Ile Leu Leu Met Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe 
        755                 760                 765             


Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg 
    770                 775                 780                 


Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu 
785                 790                 795                 800 


Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn 
                805                 810                 815     


Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
            820                 825                 830         


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
        835                 840                 845             


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
    850                 855                 860                 


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
865                 870                 875                 880 


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
                885                 890                 895     


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
            900                 905                 910         


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
        915                 920                 925             


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
    930                 935                 940                 


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
945                 950                 955                 960 


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                965                 970                 975     


<210> 106
<211> 2931
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR + IL7RaPPCL sequence"

<400> 106
gaacagaagc tgataagtga ggaggacttg gacatccaga tgacccagac caccagcagc       60

ctgagcgcca gcctgggcga tagagtgacc atcagctgca gagccagcca ggacatcagc      120

aagtacctga actggtatca gcagaaaccc gacggcaccg tgaagctgct gatctaccac      180

accagcagac tgcacagcgg cgtgcccagc agattttctg gcagcggctc cggcaccgac      240

tacagcctga ccatctccaa cctggaacag gaagatatcg ctacctactt ctgtcagcaa      300

ggcaacaccc tgccctacac cttcggcgga ggcaccaagc tggaaatcac aggcggcgga      360

ggatctggcg gaggcggaag tggcggaggg ggatctgaag tgaaactgca ggaaagcggc      420

cctggcctgg tggccccatc tcagtctctg agcgtgacct gtaccgtgtc cggcgtgtcc      480

ctgcctgact atggcgtgtc ctggatcaga cagcccccca gaaagggcct ggaatggctg      540

ggagtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc ccggctgacc      600

atcatcaagg acaactccaa gagccaggtg ttcctgaaga tgaacagcct gcagaccgac      660

gacaccgcca tctactactg cgccaagcac tactactacg gcggcagcta cgccatggac      720

tactggggcc agggcacaag cgtgaccgtg tctagcgggt ccctagacaa tgagaagagc      780

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctga gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgccggaa gagaagaggc aagcccatcc ccaacccact gctgggcctg     1440

gatagcacct ccggaagcgg agagggcaga ggctctctgc tgacctgcgg cgacgtggaa     1500

gagaacccag ggcccatgct cctgctcgtg acttcacttc ttctctgtga actcccacac     1560

cccgcgtttt tgcttatccc tcatcatcac catcaccacg gcgagagcgg ctacgcccag     1620

aacggcgacc tggaggacgc cgagctggac gactacagct tcagctgcta cagccagctg     1680

gaggtgaacg gcagccagca cagcctgacc tgcgccttcg aggaccccga cgtgaacatc     1740

accaacctgg agttcgagat ctgcggcgcc ctggtggagg tgaagtgcct gaacttcagg     1800

aagctgcagg agatctactt catcgagacc aagaagttcc tgctgatcgg caagagcaac     1860

atctgcgtga aggtgggcga gaagagcctg acctgcaaga agatcgacct gaccaccatc     1920

gtgaagcccg aggccccctt cgacctgagc gtggtgtaca gggagggcgc caacgacttc     1980

gtggtgacct tcaacaccag ccacctgcag aagaagtacg tgaaggtgct gatgcacgac     2040

gtggcctaca ggcaggagaa ggacgagaac aagtggaccc acgtgaacct gagcagcacc     2100

aagctgaccc tgctgcagag gaagctgcag cccgccgcca tgtacgagat caaggtgagg     2160

agcatccccg accactactt caagggcttc tggagcgagt ggagccccag ctactacttc     2220

aggacccccg agatcaacaa cagcagcggc gagatggacc ccatcctgct gccaccctgt     2280

ttaaccatca gcatcctgag cttcttcagc gtggccctgc tggtgatcct ggcctgcgtg     2340

ctgtggaaga agaggatcaa gcccatcgtg tggcccagcc tgcccgacca caagaagacc     2400

ctggagcacc tgtgtaagaa gcccaggaag aacctgaacg tgagcttcaa ccccgagagc     2460

ttcctggact gccagatcca cagggtggac gacatccagg ccagggacga ggtggagggc     2520

ttcctgcagg acaccttccc ccagcagctg gaggagagcg agaagcagag gctgggcggc     2580

gacgtgcaga gccccaactg ccccagcgag gacgtggtga tcacccccga gagcttcggc     2640

agggacagca gcctgacctg cctggccggc aacgtgagcg cctgcgacgc ccccatcctg     2700

agcagcagca ggagcctgga ctgcagggag agcggcaaga acggccccca cgtgtaccag     2760

gacctgctgc tgagcctggg caccaccaac agcaccctgc cacccccctt cagcctgcag     2820

agcggcatcc tgaccctgaa ccccgtggcc cagggccagc ccatcctgac cagcctgggc     2880

agcaaccagg aggaggccta cgtgaccatg agcagcttct accagaacca g              2931


<210> 107
<211> 977
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD19 CAR + IL7RaPPCL sequence"

<400> 107
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Ile Gln Met Thr Gln 
1               5                   10                  15      


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
            20                  25                  30          


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
        35                  40                  45              


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
    50                  55                  60                  


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
65                  70                  75                  80  


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
                85                  90                  95      


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
145                 150                 155                 160 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                165                 170                 175     


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        195                 200                 205             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Ser Leu Asp 
                245                 250                 255     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Arg Lys Arg Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
465                 470                 475                 480 


Asp Ser Thr Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser 
            500                 505                 510         


Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro His 
        515                 520                 525             


His His His His His Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu 
    530                 535                 540                 


Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu 
545                 550                 555                 560 


Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro 
                565                 570                 575     


Asp Val Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val 
            580                 585                 590         


Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile 
        595                 600                 605             


Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys 
    610                 615                 620                 


Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile 
625                 630                 635                 640 


Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly 
                645                 650                 655     


Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys 
            660                 665                 670         


Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp 
        675                 680                 685             


Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu 
    690                 695                 700                 


Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg 
705                 710                 715                 720 


Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro 
                725                 730                 735     


Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met 
            740                 745                 750         


Asp Pro Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe 
        755                 760                 765             


Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys 
    770                 775                 780                 


Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr 
785                 790                 795                 800 


Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe 
                805                 810                 815     


Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile 
            820                 825                 830         


Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
        835                 840                 845             


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
    850                 855                 860                 


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
865                 870                 875                 880 


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
                885                 890                 895     


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
            900                 905                 910         


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
        915                 920                 925             


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
    930                 935                 940                 


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
945                 950                 955                 960 


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
                965                 970                 975     


Gln 
    


<210> 108
<211> 1419
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      GPC3 CAR sequence"

<400> 108
gatatcgtga tgacccagag ccccgactct ttagctgtgt ctttaggaga gagggccaca       60

atcaactgca agagcagcca gagcctcctc tacagcagca accagaagaa ctatttagct      120

tggtaccagc aaaagcccgg ccagcccccc aagctgctga tctactgggc cagcagcaga      180

gagagcggcg tgcccgatag attcagcgga agcggctccg gcacagattt caccctcacc      240

attagctctt tacaagctga ggacgtggcc gtgtactact gccagcagta ctacaactac      300

cctttaacct tcggccaagg taccaagctg gagatcaagg gctccacatc cggatccggc      360

aagcccggta gcggagaagg cagcacaaag ggagaggtgc agctggtgga gagcggaggc      420

ggactggtcc agcccggtgg atctttaagg ctgtcttgtg ccgccagcgg ctttaccttt      480

aacaagaacg ctatgaactg ggtgaggcaa gctcccggta agggtttaga gtgggtgggt      540

cgtattcgta ataagaccaa caactacgcc acctactatg ccgactccgt gaaggctcgt      600

ttcaccatct ctcgtgacga cagcaagaac agcctctatt tacagatgaa ctctttaaag      660

accgaggaca ccgccgtgta ctattgcgtg gctggcaact ccttcgccta ctggggccaa      720

ggcactttag tgaccgtgag ctccgggtcc accacgacgc cagcgccgcg accaccaaca      780

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      840

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      900

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa      960

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1020

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1080

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1140

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagaggcgt     1200

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1260

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1320

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1380

acctacgacg cccttcacat gcaggccctg ccccctcgc                            1419


<210> 109
<211> 473
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      GPC3 CAR sequence"

<400> 109
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
305                 310                 315                 320 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                325                 330                 335     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            340                 345                 350         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                405                 410                 415     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            420                 425                 430         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        435                 440                 445             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    450                 455                 460                 


Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470             


<210> 110
<211> 2895
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      GPC3 CAR + IL7aCPT sequence"

<400> 110
gatatcgtga tgacccagag ccccgactct ttagctgtgt ctttaggaga gagggccaca       60

atcaactgca agagcagcca gagcctcctc tacagcagca accagaagaa ctatttagct      120

tggtaccagc aaaagcccgg ccagcccccc aagctgctga tctactgggc cagcagcaga      180

gagagcggcg tgcccgatag attcagcgga agcggctccg gcacagattt caccctcacc      240

attagctctt tacaagctga ggacgtggcc gtgtactact gccagcagta ctacaactac      300

cctttaacct tcggccaagg taccaagctg gagatcaagg gctccacatc cggatccggc      360

aagcccggta gcggagaagg cagcacaaag ggagaggtgc agctggtgga gagcggaggc      420

ggactggtcc agcccggtgg atctttaagg ctgtcttgtg ccgccagcgg ctttaccttt      480

aacaagaacg ctatgaactg ggtgaggcaa gctcccggta agggtttaga gtgggtgggt      540

cgtattcgta ataagaccaa caactacgcc acctactatg ccgactccgt gaaggctcgt      600

ttcaccatct ctcgtgacga cagcaagaac agcctctatt tacagatgaa ctctttaaag      660

accgaggaca ccgccgtgta ctattgcgtg gctggcaact ccttcgccta ctggggccaa      720

ggcactttag tgaccgtgag ctccgggtcc accacgacgc cagcgccgcg accaccaaca      780

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      840

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      900

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa      960

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1020

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1080

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1140

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagaggcgt     1200

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1260

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1320

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1380

acctacgacg cccttcacat gcaggccctg ccccctcgcg ggtccggaga gggcagaggc     1440

tctctgctga cctgcggcga cgtggaagag aacccagggc ccatgctcct gctcgtgact     1500

tcacttcttc tctgtgaact cccacacccc gcgtttttgc ttatccctca tcatcaccat     1560

caccacggcg agagcggcta cgcccagaac ggcgacctgg aggacgccga gctggacgac     1620

tacagcttca gctgctacag ccagctggag gtgaacggca gccagcacag cctgacctgc     1680

gccttcgagg accccgacgt gaacatcacc aacctggagt tcgagatctg cggcgccctg     1740

gtggaggtga agtgcctgaa cttcaggaag ctgcaggaga tctacttcat cgagaccaag     1800

aagttcctgc tgatcggcaa gagcaacatc tgcgtgaagg tgggcgagaa gagcctgacc     1860

tgcaagaaga tcgacctgac caccatcgtg aagcccgagg cccccttcga cctgagcgtg     1920

gtgtacaggg agggcgccaa cgacttcgtg gtgaccttca acaccagcca cctgcagaag     1980

aagtacgtga aggtgctgat gcacgacgtg gcctacaggc aggagaagga cgagaacaag     2040

tggacccacg tgaacctgag cagcaccaag ctgaccctgc tgcagaggaa gctgcagccc     2100

gccgccatgt acgagatcaa ggtgaggagc atccccgacc actacttcaa gggcttctgg     2160

agcgagtgga gccccagcta ctacttcagg acccccgaga tcaacaacag cagcggcgag     2220

atggacccca tcctgctgac ctgccccacc atcagcatcc tgagcttctt cagcgtggcc     2280

ctgctggtga tcctggcctg cgtgctgtgg aagaagagga tcaagcccat cgtgtggccc     2340

agcctgcccg accacaagaa gaccctggag cacctgtgta agaagcccag gaagaacctg     2400

aacgtgagct tcaaccccga gagcttcctg gactgccaga tccacagggt ggacgacatc     2460

caggccaggg acgaggtgga gggcttcctg caggacacct tcccccagca gctggaggag     2520

agcgagaagc agaggctggg cggcgacgtg cagagcccca actgccccag cgaggacgtg     2580

gtgatcaccc ccgagagctt cggcagggac agcagcctga cctgcctggc cggcaacgtg     2640

agcgcctgcg acgcccccat cctgagcagc agcaggagcc tggactgcag ggagagcggc     2700

aagaacggcc cccacgtgta ccaggacctg ctgctgagcc tgggcaccac caacagcacc     2760

ctgccacccc ccttcagcct gcagagcggc atcctgaccc tgaaccccgt ggcccagggc     2820

cagcccatcc tgaccagcct gggcagcaac caggaggagg cctacgtgac catgagcagc     2880

ttctaccaga accag                                                      2895


<210> 111
<211> 965
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      GPC3 CAR + IL7aCPT sequence"

<400> 111
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
305                 310                 315                 320 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                325                 330                 335     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            340                 345                 350         


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                405                 410                 415     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            420                 425                 430         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        435                 440                 445             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    450                 455                 460                 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu 
                485                 490                 495     


Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
            500                 505                 510         


Leu Leu Ile Pro His His His His His His Gly Glu Ser Gly Tyr Ala 
        515                 520                 525             


Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser 
    530                 535                 540                 


Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys 
545                 550                 555                 560 


Ala Phe Glu Asp Pro Asp Val Asn Ile Thr Asn Leu Glu Phe Glu Ile 
                565                 570                 575     


Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln 
            580                 585                 590         


Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser 
        595                 600                 605             


Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile 
    610                 615                 620                 


Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val 
625                 630                 635                 640 


Val Tyr Arg Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser 
                645                 650                 655     


His Leu Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr 
            660                 665                 670         


Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser 
        675                 680                 685             


Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr 
    690                 695                 700                 


Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp 
705                 710                 715                 720 


Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn 
                725                 730                 735     


Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Cys Pro Thr Ile Ser 
            740                 745                 750         


Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val 
        755                 760                 765             


Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp 
    770                 775                 780                 


His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu 
785                 790                 795                 800 


Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg 
                805                 810                 815     


Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
            820                 825                 830         


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
        835                 840                 845             


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
    850                 855                 860                 


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
865                 870                 875                 880 


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
                885                 890                 895     


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
            900                 905                 910         


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
        915                 920                 925             


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
    930                 935                 940                 


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
945                 950                 955                 960 


Phe Tyr Gln Asn Gln 
                965 


