                         SEQUENCE LISTING

<110>  Calico and AbbVie
 
<120>  PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE 
       THEREOF

<130>  CLS-014WO

<150>  US62/688226
<151>  2018-06-21

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  404
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  1

Met Ala Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr 
1               5                   10                  15      


Gln Arg Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His 
            20                  25                  30          


Asp Tyr Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn 
        35                  40                  45              


Arg Tyr Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln 
    50                  55                  60                  


Asn Ala Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu 
65                  70                  75                  80  


Ala Gln Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys 
                85                  90                  95      


Cys His Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val 
            100                 105                 110         


Met Leu Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr 
        115                 120                 125             


Trp Pro Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser 
    130                 135                 140                 


Val Lys Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu 
145                 150                 155                 160 


Leu Gln Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His 
                165                 170                 175     


Phe His Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala 
            180                 185                 190         


Ser Phe Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn 
        195                 200                 205             


Pro Asp His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg 
    210                 215                 220                 


Ser Gly Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys 
225                 230                 235                 240 


Gly Asp Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met 
            260                 265                 270         


Ala Ile Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln 
        275                 280                 285             


Lys Arg Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp 
    290                 295                 300                 


His Ser Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile 
305                 310                 315                 320 


Gly Leu Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser 
                325                 330                 335     


Ser Lys Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg 
            340                 345                 350         


Lys Arg Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln 
        355                 360                 365             


Gln Met Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Pro 
    370                 375                 380                 


Arg Leu Thr Asp Thr Glu Asn Leu Tyr Phe Gln Ser His His His His 
385                 390                 395                 400 


His His His His 
                


<210>  2
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  (Oregon Green)-(NH-CH2-CH2-O-CH2-CH2-O-CH2-CO)-L-threonine

<220>
<221>  X
<222>  (5)..(5)
<223>  O-phospho-L-tyrosine

<220>
<221>  X
<222>  (13)..(13)
<223>  L-lysine-NH2

<400>  2

Xaa Arg Asp Ile Xaa Glu Thr Asp Tyr Tyr Arg Lys Xaa 
1               5                   10              


<210>  3
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  3

Met Ala His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly 
            20                  25                  30          


Ser Trp Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe 
        35                  40                  45              


Pro Cys Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr 
    50                  55                  60                  


Arg Asp Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu 
65                  70                  75                  80  


Asp Asn Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln 
                85                  90                  95      


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His 
            100                 105                 110         


Phe Trp Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu 
        115                 120                 125             


Asn Arg Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro 
    130                 135                 140                 


Gln Lys Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu 
145                 150                 155                 160 


Thr Leu Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu 
                165                 170                 175     


Glu Leu Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe 
            180                 185                 190         


His Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser 
        195                 200                 205             


Phe Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro 
    210                 215                 220                 


Glu His Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser 
225                 230                 235                 240 


Gly Thr Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg 
                245                 250                 255     


Lys Asp Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg 
            260                 265                 270         


Lys Phe Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser 
        275                 280                 285             


Tyr Leu Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser 
    290                 295                 300                 


Val Gln Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro 
305                 310                 315                 320 


Pro Glu His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu 
                325                 330                 335     


Pro His Asn 
            


