                         SEQUENCE LISTING

<110>  Reata Pharmaceuticals, Inc.
 
<120>  CYSTEINE-DEPENDENT INVERSE AGONISTS OF NUCLEAR RECEPTORS

<130>  REAT.P0106WO

<140>  not yet known
<141>  2019-06-20

<150>  US 62/687,782
<151>  2018-06-20

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Arg Ala Pro Gln Arg Gln His Arg Ala Ser Arg Glu Leu Leu 
1               5                   10                  15      


Ala Ala Lys Lys Thr His Thr Ser Gln Ile Glu Val Ile Pro Cys Lys 
            20                  25                  30          


Ile Cys Gly Asp Lys Ser Ser Gly Ile His Tyr Gly Val Ile Thr Cys 
        35                  40                  45              


Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Gln Arg Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Ser Cys Thr Arg Gln Gln Asn Cys Pro Ile Asp Arg Thr Ser Arg 
65                  70                  75                  80  


Asn Arg Cys Gln His Cys Arg Leu Gln Lys Cys Leu Ala Leu Gly Met 
                85                  90                  95      


Ser Arg Asp Ala Val Lys Phe Gly Arg Met Ser Lys Lys Gln Arg Asp 
            100                 105                 110         


Ser Leu His Ala Glu Val Gln Lys Gln Leu Gln Gln Arg Gln Gln Gln 
        115                 120                 125             


Gln Gln Glu Pro Val Val Lys Thr Pro Pro Ala Gly Ala Gln Gly Ala 
    130                 135                 140                 


Asp Thr Leu Thr Tyr Thr Leu Gly Leu Pro Asp Gly Gln Leu Pro Leu 
145                 150                 155                 160 


Gly Ser Ser Pro Asp Leu Pro Glu Ala Ser Ala Cys Pro Pro Gly Leu 
                165                 170                 175     


Leu Lys Ala Ser Gly Ser Gly Pro Ser Tyr Ser Asn Asn Leu Ala Lys 
            180                 185                 190         


Ala Gly Leu Asn Gly Ala Ser Cys His Leu Glu Tyr Ser Pro Glu Arg 
        195                 200                 205             


Gly Lys Ala Glu Gly Arg Glu Ser Phe Tyr Ser Thr Gly Ser Gln Leu 
    210                 215                 220                 


Thr Pro Asp Arg Cys Gly Leu Arg Phe Glu Glu His Arg His Pro Gly 
225                 230                 235                 240 


Leu Gly Glu Leu Gly Gln Gly Pro Asp Ser Tyr Gly Ser Pro Ser Phe 
                245                 250                 255     


Arg Ser Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His 
            260                 265                 270         


Leu Val Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg 
        275                 280                 285             


Leu Glu Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu 
    290                 295                 300                 


Val Thr Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys 
305                 310                 315                 320 


Ala His His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys 
                325                 330                 335     


Arg Leu Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu 
            340                 345                 350         


Leu Lys Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala 
        355                 360                 365             


Tyr Asn Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly 
    370                 375                 380                 


Met Glu Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile 
385                 390                 395                 400 


Phe Asp Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu 
                405                 410                 415     


Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly 
            420                 425                 430         


Leu Gln Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu 
        435                 440                 445             


Ala Phe His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala 
    450                 455                 460                 


Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val 
465                 470                 475                 480 


Glu Arg Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala 
                485                 490                 495     


Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser 
            500                 505                 510         


Pro Val Gly Leu Ser Lys 
        515             


<210>  2
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Thr Gln Ile Glu Val Ile Pro Cys Lys Ile Cys Gly Asp Lys 
1               5                   10                  15      


Ser Ser Gly Ile His Tyr Gly Val Ile Thr Cys Glu Gly Cys Lys Gly 
            20                  25                  30          


Phe Phe Arg Arg Ser Gln Arg Cys Asn Ala Ala Tyr Ser Cys Thr Arg 
        35                  40                  45              


Gln Gln Asn Cys Pro Ile Asp Arg Thr Ser Arg Asn Arg Cys Gln His 
    50                  55                  60                  


Cys Arg Leu Gln Lys Cys Leu Ala Leu Gly Met Ser Arg Asp Ala Val 
65                  70                  75                  80  


Lys Phe Gly Arg Met Ser Lys Lys Gln Arg Asp Ser Leu His Ala Glu 
                85                  90                  95      


Val Gln Lys Gln Leu Gln Gln Arg Gln Gln Gln Gln Gln Glu Pro Val 
            100                 105                 110         


Val Lys Thr Pro Pro Ala Gly Ala Gln Gly Ala Asp Thr Leu Thr Tyr 
        115                 120                 125             


Thr Leu Gly Leu Pro Asp Gly Gln Leu Pro Leu Gly Ser Ser Pro Asp 
    130                 135                 140                 


Leu Pro Glu Ala Ser Ala Cys Pro Pro Gly Leu Leu Lys Ala Ser Gly 
145                 150                 155                 160 


Ser Gly Pro Ser Tyr Ser Asn Asn Leu Ala Lys Ala Gly Leu Asn Gly 
                165                 170                 175     


Ala Ser Cys His Leu Glu Tyr Ser Pro Glu Arg Gly Lys Ala Glu Gly 
            180                 185                 190         


Arg Glu Ser Phe Tyr Ser Thr Gly Ser Gln Leu Thr Pro Asp Arg Cys 
        195                 200                 205             


Gly Leu Arg Phe Glu Glu His Arg His Pro Gly Leu Gly Glu Leu Gly 
    210                 215                 220                 


Gln Gly Pro Asp Ser Tyr Gly Ser Pro Ser Phe Arg Ser Thr Pro Glu 
225                 230                 235                 240 


Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His Leu Val Gln Ser Val 
                245                 250                 255     


Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu 
            260                 265                 270         


Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln 
        275                 280                 285             


Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr 
    290                 295                 300                 


Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe 
305                 310                 315                 320 


Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala 
                325                 330                 335     


Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn 
            340                 345                 350         


Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg 
        355                 360                 365             


Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His 
    370                 375                 380                 


Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr 
385                 390                 395                 400 


Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg 
                405                 410                 415     


Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His 
            420                 425                 430         


Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys 
        435                 440                 445             


Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile 
    450                 455                 460                 


Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu 
465                 470                 475                 480 


Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser Pro Val Gly Leu Ser 
                485                 490                 495     


Lys 
    


