                         SEQUENCE LISTING

<110>  Exicure, Inc.
 
<120>  IL-1 BETA TARGETING SPHERICAL NUCLEIC ACIDS

<130>  A1107.70019WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/687,755
<151>  2018-06-20

<160>  145   

<170>  PatentIn version 3.5

<210>  1
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  1
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag       1498


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  2
ggucggagat tcguagcu                                                     18


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  3
agaucctctt agcacuac                                                     18


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  4
guaguggtgg tcggagau                                                     18


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  5
gcauggtgaa gtcaguua                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  6
gaaggagcac ttcaucug                                                     18


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  7
ccaaggccac agguauuu                                                     18


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  8
ccaaaugtgg ccgugguu                                                     18


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  9
gaaggagcac tgcggaga                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  10
uccagcttgt tauugauu                                                     18


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  11
ugcauggtga agucaguu                                                     18


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  12
aucccatgtg tcgaagaa                                                     18


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  13
guggucggag atucguag                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  14
uguaguggtg gtcggaga                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  15
cacaacaact gacgcggc                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  16
aaucugagct tauauauu                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  17
guuuuctgct tgagaggu                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  18
cagcuugtta ttgauuuc                                                     18


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  19
gcuaactacc ttcuucaa                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  20
ccaagctttt ttgcugug                                                     18


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  21
aauaauctga gcuuauau                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a  2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  22
ggcgngcttt aagugagu                                                     18


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  23
uucagacacc tguguaaa                                                     18


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a 2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  24
ucaucagaat gtgngagc                                                     18


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  25
uccacugacc tguaauaa                                                     18


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a phosphorothioated 7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  26
auaaauagng aagcgguu                                                     18


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a 2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  27
acgngcatgt ttucugcu                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a 2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a 2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  28
uuugngtaat ttuugnga                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  29
ucauugccac tguaauaa                                                     18


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a phosphorothioated 7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  30
ucuucuttgn gtaauuuu                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  31
agauaggttc tgaaaugu                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a  phosphorothioated 7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  32
ucagaatgtg ngagcgaa                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  33
agaacaccac ttguugcu                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a phosphorothioated 7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  34
aaauagngaa gcgguugc                                                     18


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a phosphorothioated 7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  35
cagaaugtgn gagcgaau                                                     18


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a 2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  36
agagngtttc ttagaacc                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a phosphorothioated 7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  37
uaaauagnga agcgguug                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a 2-O-methyl7-deaza-deoxyguanosine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  38
gagnguttct tagaacca                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  39
ucauugccac tguaauaa                                                     18


<210>  40
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  40
uucacutacc tccagcug                                                     18


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  41
aucuacactc tgcagcga                                                     18


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  42
aucuacactc tccagcug                                                     18


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a phosphorothioated iMe-dC

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  43
guaguggtgg tnggagau                                                     18


<210>  44
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  44
ugucgaagaa gauagguu                                                     18


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  45
gugucgaaga agauaggu                                                     18


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  46
uuaucccatg tgucgaag                                                     18


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  47
guuaucccat gtgucgaa                                                     18


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  48
cguuauccca tgugucga                                                     18


<210>  49
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  49
ucguuatccc atgugucg                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  50
cucguuatcc cauguguc                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  51
ccucgutatc ccaugugu                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be an e-modified base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may b an e-modified base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  52
gccucgttat cccaugug                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  53
gccucgttat cccaugug                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (4)..(15)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  54
gcctcgttat cccatgug                                                     18


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  55
gccucgttat cccaugug                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (6)..(13)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  56
gccucgttat cccaugug                                                     18


<210>  57
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (8)..(13)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  57
gccucgutat cccaugug                                                     18


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (10)..(15)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  58
gccucguuat cccatgug                                                     18


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  59
gccucgttat cccaugug                                                     18


<210>  60
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by polyethyleneglycol with an average molecular 
       weight of 2,500 dalton, and a 3' tri(ethyleneglycol) bound to a 
       cholesterylester

<400>  60
gccucgttat cccaugug                                                     18


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  61
agccucgtta tcccaugu                                                     18


<210>  62
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  62
aagccucgtt atcccaug                                                     18


<210>  63
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  63
uaagcctcgt taucccau                                                     18


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  64
auaagcctcg ttauccca                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  65
uggagagctt tcaguuca                                                     18


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  66
guggagagct ttcaguuc                                                     18


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  67
gguggagagc ttucaguu                                                     18


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  68
agguggagag ctuucagu                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  69
gagguggaga gcuuucag                                                     18


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  70
ggagguggag agcuuuca                                                     18


<210>  71
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  71
uggaggtgga gagcuuuc                                                     18


<210>  72
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  72
cuggaggtgg agagcuuu                                                     18


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  73
ccuggaggtg gagagcuu                                                     18


<210>  74
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  74
cccuggaggt ggagagcu                                                     18


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (4)..(15)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  75
ccctggaggt ggagagcu                                                     18


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  76
ccctggaggu ggagagcu                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  77
cccuggaggt ggagagcu                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (6)..(13)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  78
cccuggaggt ggagagcu                                                     18


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (8)..(13)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  79
cccuggaggt ggagagcu                                                     18


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (10)..(15)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  80
cccuggaggt ggagagcu                                                     18


<210>  81
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  81
ucccuggagg tggagagc                                                     18


<210>  82
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  82
guauuutgtc atuacuuu                                                     18


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  83
gguauuttgt cauuacuu                                                     18


<210>  84
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  84
cagguatttt gtcauuac                                                     18


<210>  85
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  85
acagguattt tgucauua                                                     18


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  86
cacaggtatt ttgucauu                                                     18


<210>  87
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  87
ccacaggtat ttugucau                                                     18


<210>  88
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  88
gccacaggta ttuuguca                                                     18


<210>  89
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  89
ggccacaggt atuuuguc                                                     18


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  90
aggccacagg tauuuugu                                                     18


<210>  91
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  91
aaggccacag gtauuuug                                                     18


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  92
caaggccaca gguauuuu                                                     18


<210>  93
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  93
cccaaggcca cagguauu                                                     18


<210>  94
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  94
uucuuugggt aauuuuug                                                     18


<210>  95
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  95
cuucuutggg taauuuuu                                                     18


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  96
ucuucuttgg gtaauuuu                                                     18


<210>  97
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  97
uucuuctttg gguaauuu                                                     18


<210>  98
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  98
uuccagcttg ttauugau                                                     18


<210>  99
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  99
aauuccagct tguuauug                                                     18


<210>  100
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  100
caaauuccag ctuguuau                                                     18


<210>  101
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  101
guaccagttg gggaacug                                                     18


<210>  102
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  102
auguaccagt tggggaac                                                     18


<210>  103
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  103
ugauguacca gtugggga                                                     18


<210>  104
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  104
aggugctgat gtaccagu                                                     18


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  105
gaggugctga tguaccag                                                     18


<210>  106
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  106
agaggugctg atguacca                                                     18


<210>  107
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  107
gagaggtgct gauguacc                                                     18


<210>  108
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  108
ugagaggtgc tgauguac                                                     18


<210>  109
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  109
uugagaggtg ctgaugua                                                     18


<210>  110
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  110
cuugagaggt gcugaugu                                                     18


<210>  111
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  111
gcuugagagg tgcugaug                                                     18


<210>  112
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  112
ugcuugagag gtgcugau                                                     18


<210>  113
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  113
cugcuugaga ggugcuga                                                     18


<210>  114
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  114
ucugcutgag aggugcug                                                     18


<210>  115
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  115
cgggcatgtt ttcugcuu                                                     18


<210>  116
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  116
gacgggcatg ttuucugc                                                     18


<210>  117
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  117
aagacgggca tguuuucu                                                     18


<210>  118
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  118
gaagacgggc atguuuuc                                                     18


<210>  119
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  119
aauugcatgg tgaaguca                                                     18


<210>  120
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  120
aaauugcatg gtgaaguc                                                     18


<210>  121
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  121
caaauugcat ggugaagu                                                     18


<210>  122
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  122
acaaautgca tggugaag                                                     18


<210>  123
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  123
cacaaattgc atggugaa                                                     18


<210>  124
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  124
uugggcattg gtguagac                                                     18


<210>  125
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  125
guugggcatt gguguaga                                                     18


<210>  126
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  126
aguugggcat tgguguag                                                     18


<210>  127
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  127
caguugggca ttggugua                                                     18


<210>  128
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  128
gcaguugggc atuggugu                                                     18


<210>  129
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  129
ggcagutggg cauuggug                                                     18


<210>  130
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  130
aggcagttgg gcauuggu                                                     18


<210>  131
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  131
caggcagttg ggcauugg                                                     18


<210>  132
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  132
cagagggttt ctuagaac                                                     18


<210>  133
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  133
gacagagggt ttcuuaga                                                     18


<210>  134
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  134
aaugacagag gguuucuu                                                     18


<210>  135
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  135
aauaaatagg gaagcggu                                                     18


<210>  136
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  136
uaaauaaata gggaagcg                                                     18


<210>  137
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  137
aauaaataaa tagggaag                                                     18


<210>  138
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  138
gagcuuatat atuuucag                                                     18


<210>  139
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  139
cugagcttat atauuuuc                                                     18


<210>  140
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  140
guaguggtgg tcggagau                                                     18


<210>  141
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  may be a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  may be a 2'-O-methylated base

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be modified by two internal hexaethylene gylcol spacers, and 
       a 3' tri(ethyleneglycol) bound to a cholesterylester

<400>  141
guaguggtgg tcggagau                                                     18


<210>  142
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  142
caaggtcatc catgacaact ttg                                               23


<210>  143
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  143
gggccatcca cagtcttct                                                    19


<210>  144
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  144
accacagtcc atgccatcac tgcca                                             25


<210>  145
<211>  1421
<212>  DNA
<213>  Homo sapiens

<400>  145
gcctcaagac cttgggctgg gactggctga gcctggcggg aggcggggtc cgagtcaccg       60

cctgccgccg cgcccccggt ttctataaat tgagcccgca gcctcccgct tcgctctctg      120

ctcctcctgt tcgacagtca gccgcatctt cttttgcgtc gccagccgag ccacatcgct      180

cagacaccat ggggaaggtg aaggtcggag tcaacggatt tggtcgtatt gggcgcctgg      240

tcaccagggc tgcttttaac tctggtaaag tggatattgt tgccatcaat gaccccttca      300

ttgacctcaa ctacatggtt tacatgttcc aatatgattc cacccatggc aaattccatg      360

gcaccgtcaa ggctgagaac gggaagcttg tcatcaatgg aaatcccatc accatcttcc      420

aggagcgaga tccctccaaa atcaagtggg gcgatgctgg cgctgagtac gtcgtggagt      480

ccactggcgt cttcaccacc atggagaagg ctggggctca tttgcagggg ggagccaaaa      540

gggtcatcat ctctgccccc tctgctgatg cccccatgtt cgtcatgggt gtgaaccatg      600

agaagtatga caacagcctc aagatcatca gcaatgcctc ctgcaccacc aactgcttag      660

cacccctggc caaggtcatc catgacaact ttggtatcgt ggaaggactc atgaccacag      720

tccatgccat cactgccacc cagaagactg tggatggccc ctccgggaaa ctgtggcgtg      780

atggccgcgg ggctctccag aacatcatcc ctgcctctac tggcgctgcc aaggctgtgg      840

gcaaggtcat ccctgagctg aacgggaagc tcactggcat ggccttccgt gtccccactg      900

ccaacgtgtc agtggtggac ctgacctgcc gtctagaaaa acctgccaaa tatgatgaca      960

tcaagaaggt ggtgaagcag gcgtcggagg gccccctcaa gggcatcctg ggctacactg     1020

agcaccaggt ggtctcctct gacttcaaca gcgacaccca ctcctccacc tttgacgctg     1080

gggctggcat tgccctcaac gaccactttg tcaagctcat ttcctggtat gacaacgaat     1140

ttggctacag caacagggtg gtggacctca tggcccacat ggcctccaag gagtaagacc     1200

cctggaccac cagccccagc aagagcacaa gaggaagaga gagaccctca ctgctgggga     1260

gtccctgcca cactcagtcc cccaccacac tgaatctccc ctcctcacag ttgccatgta     1320

gaccccttga agaggggagg ggcctaggga gccgcacctt gtcatgtacc atcaataaag     1380

taccctgtgc tcaaccagtt aaaaaaaaaa aaaaaaaaaa a                         1421


