                         SEQUENCE LISTING

<110>  Midwestern University
       Olsen, Mark A
 
<120>  Monoclonal Antibodies Targeting Epitopes of ASPH

<130>  761_190_025_US

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  758
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(758)
<223>  Polypeptide corresponding to Human ASPH deposited as Accession No
       Q12797, starting at the N-terminus with MAQRKNAKSS and ending at 
       the C-terminus with PQQRRSLPAI.

<400>  1

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 
    210                 215                 220                 


Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 
225                 230                 235                 240 


Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr 
                245                 250                 255     


Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu 
            260                 265                 270         


Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val 
        275                 280                 285             


Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu 
    290                 295                 300                 


Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro 
305                 310                 315                 320 


Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys 
                325                 330                 335     


Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg 
            340                 345                 350         


Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val 
        355                 360                 365             


Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys 
    370                 375                 380                 


Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly 
385                 390                 395                 400 


Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala 
                405                 410                 415     


Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe 
            420                 425                 430         


Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln 
        435                 440                 445             


Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr 
    450                 455                 460                 


Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val 
465                 470                 475                 480 


Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe 
                485                 490                 495     


Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys 
            500                 505                 510         


Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr 
        515                 520                 525             


Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr 
    530                 535                 540                 


Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp 
545                 550                 555                 560 


Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp 
                565                 570                 575     


Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg 
            580                 585                 590         


Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala 
        595                 600                 605             


Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp 
    610                 615                 620                 


Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala 
625                 630                 635                 640 


Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu 
                645                 650                 655     


Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro 
            660                 665                 670         


Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg 
        675                 680                 685             


Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys 
    690                 695                 700                 


Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp 
705                 710                 715                 720 


Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu 
                725                 730                 735     


Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg 
            740                 745                 750         


Arg Ser Leu Pro Ala Ile 
        755             


<210>  2
<211>  794
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(794)
<223>  Canine ASPH corresponding to GenBank ACCESSION   XP_022267901 - 
       aspartyl/asparaginyl beta-hydroxylase isoform X1 [Canis lupus 
       familiaris]

<400>  2

Met Ala Glu Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly 
1               5                   10                  15      


Gly Leu Ser Gly Ser Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu 
            20                  25                  30          


Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp 
        35                  40                  45              


Tyr Glu Glu Val Leu Ala Lys Ala Lys Asp Phe Arg Tyr Asn Leu Ser 
    50                  55                  60                  


Glu Val Leu Gln Gly Lys Leu Gly Val Tyr Asp Ala Asp Gly Asp Gly 
65                  70                  75                  80  


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Thr Lys Asp 
                85                  90                  95      


Gly Ser Asn Glu Asn Ile Asp Ser Leu Glu Glu Val Leu Asn Ile Leu 
            100                 105                 110         


Ala Glu Glu Ser Ser Asp Trp Phe Tyr Gly Phe Leu Ser Phe Leu Tyr 
        115                 120                 125             


Asp Ile Met Thr Pro Phe Glu Met Leu Glu Glu Glu Glu Glu Glu Ser 
    130                 135                 140                 


Glu Thr Ala Asp Gly Val Asp Gly Leu Lys Glu Arg Ser Ala Ser Lys 
145                 150                 155                 160 


Pro Thr Val Pro Pro Glu Glu Ala Glu Pro Tyr Pro Trp Leu Glu Glu 
                165                 170                 175     


Gln Val Ile Glu Asp Ser Gly Pro Gln Asn Thr Glu Asp Glu Val Gln 
            180                 185                 190         


Glu Val Gln Ile Glu Ser Leu Leu His Glu Ala Val Tyr Thr Glu His 
        195                 200                 205             


Gly Asp Asp Val Gln Gln Glu Glu Asp Gly Gln Val Arg Glu Pro Gln 
    210                 215                 220                 


Pro Glu Asp Asp Phe Leu Val Gly Ser Asp Thr Asp Asp Arg Tyr Glu 
225                 230                 235                 240 


Pro Leu Glu Thr Gly Thr Phe His Glu Glu Thr Glu Asp Ser Tyr His 
                245                 250                 255     


Ile Glu Glu Thr Ala Ser Gln Ala Tyr Asn Gln Asp Met Glu Glu Met 
            260                 265                 270         


Met Tyr Glu Gln Asp Asn Pro Asp Ser Met Glu Pro Ile Val Gly Asp 
        275                 280                 285             


Asp Ala Arg Thr Tyr His Glu Ala Asp Asp Leu Thr Tyr Gln Asp Tyr 
    290                 295                 300                 


Asp Glu Pro Val Tyr Glu Pro Pro Glu Asn Glu Gly Leu Glu Ser Ser 
305                 310                 315                 320 


Asp Asn Ala Gly Glu Asp Ser Asn Ile Ile Leu Glu Glu Val Tyr Met 
                325                 330                 335     


Pro Pro Ala Glu Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys 
            340                 345                 350         


Thr Asp Asp Pro Glu Ile Lys Glu Lys Val Lys Lys Lys Lys Pro Lys 
        355                 360                 365             


Leu Leu Asn Lys Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala 
    370                 375                 380                 


Glu Lys Leu Arg Lys Arg Gly Lys Ile Glu Glu Ala Leu Ser Ala Phe 
385                 390                 395                 400 


Gln Glu Leu Val Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly 
                405                 410                 415     


Lys Ala Gln Cys Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu 
            420                 425                 430         


Val Leu Arg Gly Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro 
        435                 440                 445             


Asn Val Pro Thr Asp Leu Leu Lys Leu Thr Leu Lys Arg Arg Ser Asp 
    450                 455                 460                 


Arg Gln Gln Phe Leu Gly His Met Arg Gly Ser Leu Ile Thr Leu Gln 
465                 470                 475                 480 


Lys Leu Val Gln Leu Phe Pro Asp Asp Met Ser Leu Lys Asn Asp Leu 
                485                 490                 495     


Gly Val Gly Tyr Leu Leu Ile Gly Asp Asn Asn Asn Ala Gln Lys Val 
            500                 505                 510         


Tyr Glu Glu Val Leu Asn Val Thr Pro Asn Asp Gly Phe Ala Lys Val 
        515                 520                 525             


His Tyr Gly Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile 
    530                 535                 540                 


Pro Tyr Leu Lys Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp 
545                 550                 555                 560 


Gly Arg Phe Tyr Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn 
                565                 570                 575     


Lys Glu Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe 
            580                 585                 590         


Ala Ser Val Trp Gln Arg Ser Leu Tyr Asn Val His Gly Leu Lys Ala 
        595                 600                 605             


Gln Pro Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys 
    610                 615                 620                 


Ser Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val 
625                 630                 635                 640 


Met Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg 
                645                 650                 655     


Glu Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Lys 
            660                 665                 670         


Asn Glu Asn Ala Cys Lys Gly Ala Pro Lys Thr Cys Ser Leu Leu Asp 
        675                 680                 685             


Lys Phe Pro Glu Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser 
    690                 695                 700                 


Ile Met His Pro Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn 
705                 710                 715                 720 


Cys Arg Leu Arg Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys 
                725                 730                 735     


Lys Ile Arg Cys Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val 
            740                 745                 750         


Leu Ile Phe Asp Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Thr 
        755                 760                 765             


Ser Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr 
    770                 775                 780                 


Pro Gln Gln Arg His Ser Leu Pro Ala Ile 
785                 790                 


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  KRRSNEVLR corresponding to residues 391-399 of ASPH

<400>  3

Lys Arg Arg Ser Asn Glu Val Leu Arg 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  DRQQFLGHM corresponding to residues 428-436 of ASPH

<400>  4

Asp Arg Gln Gln Phe Leu Gly His Met 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  GYLLIGDNDN corresponding to residues 463-470 of ASPH

<400>  5

Gly Tyr Leu Leu Ile Gly Asp Asn Asp Asn 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  RSLYNVNG corresponding to residues 562-569 of ASPH

<400>  6

Arg Ser Leu Tyr Asn Val Asn Gly 
1               5               


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  PQQRRSLPAI corresponding to residues 749-758 of ASPH

<400>  7

Pro Gln Gln Arg Arg Ser Leu Pro Ala Ile 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  FLPEDENLRE corresponding to residues 612-621 of human ASPH

<400>  8

Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VWPHTGPTNC corresponding to residues 676-685 of human ASPH

<400>  9

Val Trp Pro His Thr Gly Pro Thr Asn Cys 
1               5                   10  


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  LWQQGRRNE corresponding to residues 630-638 of human ASPH

<400>  10

Leu Trp Gln Gln Gly Arg Arg Asn Glu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Peptide #C1, KRRSNEVLR, corresponding to residues 427-435 of 
       canine ASPH

<400>  11

Lys Arg Arg Ser Asn Glu Val Leu Arg 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Peptide #C2, DRQQFLGHM, corresponding to residues 464-472 of 
       canine ASPH

<400>  12

Asp Arg Gln Gln Phe Leu Gly His Met 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  Peptide #C3, GYLLIGDNNN, corresponding to residues 499-508 of 
       canine ASPH

<400>  13

Gly Tyr Leu Leu Ile Gly Asp Asn Asn Asn 
1               5                   10  


<210>  14
<211>  8
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  Peptide #C4, RSLYNVHG, corresponding to residues 598-605 of 
       canine ASPH

<400>  14

Arg Ser Leu Tyr Asn Val His Gly 
1               5               


<210>  15
<211>  10
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  Peptide #C5, PQQRHSLPA,I corresponding to residues 785-794 of 
       canine ASPH

<400>  15

Pro Gln Gln Arg His Ser Leu Pro Ala Ile 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  FLPEDENLRE corresponding to residues 648-657 of canine ASPH

<400>  16

Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VWPHTGPTNC corresponding to residues 712-721 of canine ASPH

<400>  17

Val Trp Pro His Thr Gly Pro Thr Asn Cys 
1               5                   10  


<210>  18
<211>  9
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  LWQQGRKNE corresponding to residues 666-674 of canine ASPH

<400>  18

Leu Trp Gln Gln Gly Arg Lys Asn Glu 
1               5                   


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(29)
<223>  Synthetic peptide comprising 29 amino acids with Cysteine at its 
       amino terminus, plus 28 amino acids corresponding to positions 
       731-758 at the C-terminal end of human ASPH, with the Threonine 
       at 19 (corresponding to 748 of ASPH) phosphorylated.

<220>
<221>  PHOSPHORYLATION
<222>  (19)..(19)
<223>  Synthetic peptide comprising 29 amino acids with Cysteine at its 
       amino terminus, plus 28 amino acids corresponding to positions 
       731-758 at the C-terminal end of human ASPH, with the Threonine 
       at 19 (corresponding to 748 of ASPH) phosphorylated.

<400>  19

Cys Ala Ser Ser Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro 
1               5                   10                  15      


Glu Leu Thr Pro Gln Gln Arg Arg Ser Leu Pro Ala Ile 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(29)
<223>  Synthetic peptide comprising 29 amino acids with Cysteine at its 
       amino terminus, plus 28 amino acids corresponding to positions 
       731-758 at the C-terminal end of human ASPH.

<400>  20

Cys Ala Ser Ser Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro 
1               5                   10                  15      


Glu Leu Thr Pro Gln Gln Arg Arg Ser Leu Pro Ala Ile 
            20                  25                  


<210>  21
<211>  150
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(150)
<223>  Translated variable region of Clone ID #1H2 comprising a GQPK 
       sequence at the start of the constant region for a heavy chain 
       sequence

<400>  21

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Leu Ser Phe Ser 
        35                  40                  45              


Asp Asn Phe Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Ala Cys Ile Tyr Phe Asp Ser Ser Gly Ile Thr Tyr Tyr Ala 
65                  70                  75                  80  


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Pro Thr 
                85                  90                  95      


Val Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr 
            100                 105                 110         


Phe Cys Ala Arg Asp Gly Pro Gly Ser Ile Ser Trp Asp Leu Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro 
145                 150 


<210>  22
<211>  148
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(148)
<223>  Translated variable region of Clone ID #1K6 comprising a GDPV 
       sequence at the start of the constant region for a kappa sequence

<400>  22

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Lys Ser Val Tyr Ser Lys Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Thr Tyr Asp Ser Ser Gly Trp Tyr Trp Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
    130                 135                 140                 


Phe Pro Pro Ala 
145             


<210>  23
<211>  142
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(142)
<223>  Translated variable region of Clone ID #5H1

<400>  23

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Ser Asn Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
    50                  55                  60                  


Trp Ile Ala Cys Ile Asp Asn Gly Asp Gly Ser Thr Asp Tyr Ala Thr 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
                85                  90                  95      


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Thr Arg Asn Phe Asn Leu Trp Gly Pro Gly His Pro Gly His Arg 
        115                 120                 125             


Leu Glu Arg Thr Ala Glu Ser Pro Val Gly Val Ser Thr Gly 
    130                 135                 140         


<210>  24
<211>  143
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(143)
<223>  Translated variable region of Clone ID #5H3 comprising a GQPK 
       sequence at the start of the constant region for a heavy chain 
       sequence

<400>  24

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Ser Asn Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
    50                  55                  60                  


Trp Ile Ala Cys Ile Asp Asn Gly Asp Gly Ser Thr Asp Tyr Ala Thr 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
                85                  90                  95      


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Thr Arg Asn Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140             


<210>  25
<211>  143
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(143)
<223>  Translated variable region of Clone ID #5H4 comprising a GQPK 
       sequence at the start of the constant region for a heavy chain 
       sequence

<400>  25

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Ser Asn Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
    50                  55                  60                  


Trp Ile Ala Cys Ile Asp Asn Gly Asp Gly Ser Thr Asp Tyr Ala Thr 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
                85                  90                  95      


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Thr Arg Asn Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140             


<210>  26
<211>  146
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(146)
<223>  Translated variable region of Clone ID #5K1 comprising a GDPV 
       sequence at the start of the constant region for a kappa sequence

<400>  26

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Arg Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Leu Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Ser Gly Tyr Ile Tyr Thr Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala 
145     


<210>  27
<211>  146
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(146)
<223>  Translated variable region of Clone ID #5K3 comprising a GDPV 
       sequence at the start of the constant region for a kappa sequence

<400>  27

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Arg Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Leu Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Ser Gly Tyr Ile Tyr Thr Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala 
145     


<210>  28
<211>  146
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(146)
<223>  Translated variable region of Clone ID #5K6 comprising a GDPV 
       sequence at the start of the constant region for a kappa sequence

<400>  28

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Arg Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Leu Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Ser Gly Tyr Ile Tyr Thr Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala 
145     


<210>  29
<211>  142
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(142)
<223>  Translated variable region of Clone ID #9H2 comprising a GQPK 
       sequence at the start of the constant region for a heavy chain 
       sequence

<400>  29

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ile 
        35                  40                  45              


Ser Asn Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
    50                  55                  60                  


Trp Ile Ala Cys Ile Asp Asn Gly Asp Gly Ser Thr Asp Tyr Ala Thr 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
                85                  90                  95      


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Thr Arg Asn Phe Asn Leu Trp Gly Gln Gly Thr Leu Thr Val Ser 
        115                 120                 125             


Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140         


<210>  30
<211>  146
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  PEPTIDE
<222>  (1)..(146)
<223>  Translated variable region of Clone ID #9K1 comprising a GDPV 
       sequence at the start of the constant region for a kappa sequence

<400>  30

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Arg Leu Ala Trp Phe Gln Gln Lys Ser 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Leu Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Ser Gly Tyr Ile Tyr Thr Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala 
145     


