                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  CELL

<130>  P114775PCT

<150>  GB 1810070.1
<151>  2018-06-19

<150>  GB 1905652.2
<151>  2019-04-23

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibronectin type III (FN3) scaffold, Nsa1

<400>  1

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly Ser Gly Gly Tyr Ala Trp Gln Glu Phe 
        35                  40                  45              


Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Tyr Tyr Gly Tyr Pro 
65                  70                  75                  80  


Thr Tyr Tyr Ser Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90              


<210>  2
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FN3 scaffold, Nsa5

<400>  2

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Phe Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly Tyr Phe Ser Gly Phe Gln Glu Phe Glu 
        35                  40                  45              


Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
    50                  55                  60                  


Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Tyr Tyr Gly Tyr Tyr Gly 
65                  70                  75                  80  


Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD loop of FN3 scaffold, Nsa1

<400>  3

Ser Gly Gly Tyr Ala Trp 
1               5       


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG loop of FN3 scaffold, Nsa1

<400>  4

Ala Gly Tyr Tyr Gly Tyr Pro Thr Tyr Tyr Ser Ser 
1               5                   10          


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD loop of FN3 scaffold, Nsa5

<400>  5

Tyr Phe Ser Gly Phe 
1               5   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG loop of FN3 scaffold, Nsa5

<400>  6

Ala Gly Tyr Tyr Gly Tyr Tyr Gly Ser 
1               5                   


<210>  7
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  8
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn 
1               5                   10                  15      


Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile 
            20                  25                  30          


Asn Leu Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Met Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val 
    50                  55                  60                  


Asn Glu Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr 
65                  70                  75                  80  


Ala Glu Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly 
                85                  90                  95      


Lys Lys Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn 
            100                 105                 110         


Leu Cys Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile 
        115                 120                 125             


Thr Ser Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu 
    130                 135                 140                 


Val 
145 


<210>  9
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Pro Phe Leu Val Leu Leu His Ser Val Ser Ser Ser Leu Ser 
1               5                   10                  15      


Ser Ser Glu Leu Thr Glu Leu Lys Phe Leu Cys Leu Gly Arg Val Gly 
            20                  25                  30          


Lys Arg Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 
        35                  40                  45              


Leu Leu Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg 
    50                  55                  60                  


Glu Leu Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp 
65                  70                  75                  80  


Asp Phe Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu Glu Asp 
                85                  90                  95      


Leu Cys Ala Ala Phe Asn Val Ile Cys Asp Asn Val Gly Lys Asp Trp 
            100                 105                 110         


Arg Arg Leu Ala Arg Gln Leu Lys Val Ser Asp Thr Lys Ile Asp Ser 
        115                 120                 125             


Ile Glu Asp Arg Tyr Pro Arg Asn Leu Thr Glu Arg Val Arg Glu Ser 
    130                 135                 140                 


Leu Arg Ile Trp Lys Asn Thr Glu Lys Glu Asn Ala Thr Val Ala His 
145                 150                 155                 160 


Leu Val Gly Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu 
                165                 170                 175     


Val Gln Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala 
            180                 185                 190         


Met Ser Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser 
        195                 200                 205             


<210>  10
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  11
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Gly Gln Asn Gly His Glu Glu Trp Val Gly Ser Ala Tyr 
1               5                   10                  15      


Leu Phe Val Glu Ser Ser Leu Asp Lys Val Val Leu Ser Asp Ala Tyr 
            20                  25                  30          


Ala His Pro Gln Gln Lys Val Ala Val Tyr Arg Ala Leu Gln Ala Ala 
        35                  40                  45              


Leu Ala Glu Ser Gly Gly Ser Pro Asp Val Leu Gln Met Leu Lys Ile 
    50                  55                  60                  


His Arg Ser Asp Pro Gln Leu Ile Val Gln Leu Arg Phe Cys Gly Arg 
65                  70                  75                  80  


Gln Pro Cys Gly Arg Phe Leu Arg Ala Tyr Arg Glu Gly Ala Leu Arg 
                85                  90                  95      


Ala Ala Leu Gln Arg Ser Leu Ala Ala Ala Leu Ala Gln His Ser Val 
            100                 105                 110         


Pro Leu Gln Leu Glu Leu Arg Ala Gly Ala Glu Arg Leu Asp Ala Leu 
        115                 120                 125             


Leu Ala Asp Glu Glu Arg Cys Leu Ser Cys Ile Leu Ala Gln Gln Pro 
    130                 135                 140                 


Asp Arg Leu Arg Asp Glu Glu Leu Ala Glu Leu Glu Asp Ala Leu Arg 
145                 150                 155                 160 


Asn Leu Lys Cys Gly Ser Gly Ala Arg Gly Gly Asp Gly Glu Val Ala 
                165                 170                 175     


Ser Ala Pro Leu Gln Pro Pro Val Pro Ser Leu Ser Glu Val Lys Pro 
            180                 185                 190         


Pro Pro Pro Pro Pro Pro Ala Gln Thr Phe Leu Phe Gln Gly Gln Pro 
        195                 200                 205             


Val Val Asn Arg Pro Leu Ser Leu Lys Asp Gln Gln Thr Phe Ala Arg 
    210                 215                 220                 


Ser Val Gly Leu Lys Trp Arg Lys Val Gly Arg Ser Leu Gln Arg Gly 
225                 230                 235                 240 


Cys Arg Ala Leu Arg Asp Pro Ala Leu Asp Ser Leu Ala Tyr Glu Tyr 
                245                 250                 255     


Glu Arg Glu Gly Leu Tyr Glu Gln Ala Phe Gln Leu Leu Arg Arg Phe 
            260                 265                 270         


Val Gln Ala Glu Gly Arg Arg Ala Thr Leu Gln Arg Leu Val Glu Ala 
        275                 280                 285             


Leu Glu Asn Glu Leu Thr Ser Leu Ala Glu Asp Leu Leu Gly Leu Thr 
    290                 295                 300                 


Asp Pro Asn Gly Gly Leu Ala 
305                 310     


<210>  12
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys 
1               5                   10                  15      


Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser 
            20                  25                  30          


Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys 
        35                  40                  45              


Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn 
    50                  55                  60                  


Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly 
65                  70                  75                  80  


Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala 
                85                  90                  95      


Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val 
            100                 105                 110         


Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val 
        115                 120                 125             


Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser 
    130                 135                 140                 


Gly Leu Thr Leu Gln Ser Asn Ala Pro Ser Ser Met Met Val Lys Asp 
145                 150                 155                 160 


Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Ser Thr Glu Gly 
                165                 170                 175     


His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr 
            180                 185                 190         


Glu Thr Tyr Ser Thr Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala 
        195                 200                 205             


Thr Ser Thr Ala Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln 
    210                 215                 220                 


Pro Ala Ser Ile Leu Gly Gly Ser His Ser Glu Gly Leu Leu Gln Ile 
225                 230                 235                 240 


Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Gly Gln 
                245                 250                 255     


Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg 
            260                 265                 270         


Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu 
        275                 280                 285             


Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val 
    290                 295                 300                 


His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro 
305                 310                 315                 320 


Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly 
                325                 330                 335     


Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly 
            340                 345                 350         


Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser 
        355                 360                 365             


Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly 
    370                 375                 380                 


Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg 
385                 390                 395                 400 


Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg 
                405                 410                 415     


Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser 
            420                 425                 430         


Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln 
        435                 440                 445             


Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala 
    450                 455                 460                 


Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro 
465                 470                 475                 480 


Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg 
                485                 490                 495     


Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp 
            500                 505                 510         


Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His 
        515                 520                 525             


Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro 
    530                 535                 540                 


Ile Ala Asp Pro Gln Pro Leu Asp 
545                 550         


<210>  13
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  13

Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly Glu Thr 
1               5                   10                  15      


Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly Tyr Val 
            20                  25                  30          


Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser Asn Val 
        35                  40                  45              


His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly Lys Gly 
    50                  55                  60                  


Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg Cys Leu 
65                  70                  75                  80  


Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg Glu Ala 
                85                  90                  95      


Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser Ala Tyr 
            100                 105                 110         


Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln Gln Gln 
        115                 120                 125             


Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala Val Ala 
    130                 135                 140                 


Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro Ala Ile 
145                 150                 155                 160 


Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg Arg Leu 
                165                 170                 175     


Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp Tyr Pro 
            180                 185                 190         


Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His Leu His 
        195                 200                 205             


Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro Ile Ala 
    210                 215                 220                 


Asp Pro Gln Pro Leu Asp 
225                 230 


<210>  14
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
1               5                   10                  15      


Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
            20                  25                  30          


Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
        35                  40                  45              


Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
    50                  55                  60                  


Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
65                  70                  75                  80  


Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                85                  90                  95      


Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
            100                 105                 110         


Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly Asn 
    130                 135                 140                 


Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val Gly 
145                 150                 155                 160 


Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu Lys 
                165                 170                 175     


Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile His 
            180                 185                 190         


Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp Val 
        195                 200                 205             


Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala Val 
    210                 215                 220                 


Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly Ala 
225                 230                 235                 240 


Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu Thr 
                245                 250                 255     


Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu Thr 
            260                 265                 270         


Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser Tyr 
        275                 280                 285             


Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro Tyr 
    290                 295                 300                 


Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
305                 310                 315     


<210>  15
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45 trans-membrane and endodomain sequence

<400>  15

Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
1               5                   10                  15      


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
            20                  25                  30          


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
        35                  40                  45              


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
    50                  55                  60                  


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
65                  70                  75                  80  


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
                85                  90                  95      


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
            100                 105                 110         


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
        115                 120                 125             


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
    130                 135                 140                 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
145                 150                 155                 160 


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
                165                 170                 175     


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
            180                 185                 190         


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
        195                 200                 205             


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
    210                 215                 220                 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
225                 230                 235                 240 


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
            260                 265                 270         


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
        275                 280                 285             


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
    290                 295                 300                 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
305                 310                 315                 320 


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
                325                 330                 335     


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
            340                 345                 350         


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
        355                 360                 365             


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
    370                 375                 380                 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
385                 390                 395                 400 


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
                405                 410                 415     


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
            420                 425                 430         


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
        435                 440                 445             


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
    450                 455                 460                 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
465                 470                 475                 480 


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
                485                 490                 495     


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
            500                 505                 510         


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
        515                 520                 525             


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
    530                 535                 540                 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
545                 550                 555                 560 


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
                565                 570                 575     


Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys 
            580                 585                 590         


Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu 
        595                 600                 605             


Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val 
    610                 615                 620                 


Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln 
625                 630                 635                 640 


Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn 
                645                 650                 655     


Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp 
            660                 665                 670         


Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu 
        675                 680                 685             


Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser 
    690                 695                 700                 


Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro 
705                 710                 715                 720 


Ala Ser Pro Ala Leu Asn Gln Gly Ser 
                725                 


<210>  16
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD148 trans-membrane and endodomain sequence

<400>  16

Ala Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly 
1               5                   10                  15      


Gly Phe Ile Phe Trp Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu 
            20                  25                  30          


Val Ser Phe Ser Gln Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val 
        35                  40                  45              


Glu Asn Phe Glu Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys 
    50                  55                  60                  


Gly Phe Ala Glu Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln 
65                  70                  75                  80  


Pro Lys Tyr Ala Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr 
                85                  90                  95      


Asn Asn Val Leu Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln 
            100                 105                 110         


Thr His Ser Thr Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr 
        115                 120                 125             


His Ser Lys Lys Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr 
    130                 135                 140                 


Leu Lys Asp Phe Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile 
145                 150                 155                 160 


Ile Met Leu Thr Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu 
                165                 170                 175     


Tyr Trp Pro Ser Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala 
            180                 185                 190         


Met Thr Ser Glu Ile Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr 
        195                 200                 205             


Val Lys Asn Ile Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe His 
    210                 215                 220                 


Phe Thr Ser Trp Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu 
225                 230                 235                 240 


Ile Asn Phe Arg Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro 
                245                 250                 255     


Glu Ser Pro Ile Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly 
            260                 265                 270         


Thr Phe Ile Ala Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn 
        275                 280                 285             


Thr Val Asp Val Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro 
    290                 295                 300                 


Leu Met Val Gln Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val 
305                 310                 315                 320 


Leu Asp Ile Val Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr 
                325                 330                 335     


Gln Asn Thr Thr Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr 
            340                 345                 350         


Thr Phe Gly Lys Thr Asn Gly Tyr Ile Ala 
        355                 360         


<210>  17
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein tyrosine phosphatase (PTP) PTPN6 sequence

<400>  17

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  18
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  phosphatase domain of PTPN6

<400>  18

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


<210>  19
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTPN11 sequence

<400>  19

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu 
                405                 410                 415     


Arg Thr Val Trp Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val 
            420                 425                 430         


Pro Ser Asp Pro Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His 
        435                 440                 445             


Lys Gln Glu Ser Ile Met Asp Ala Gly Pro Val Val Val His Cys Ser 
    450                 455                 460                 


Ala Gly Ile Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile 
465                 470                 475                 480 


Asp Ile Ile Arg Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys 
                485                 490                 495     


Thr Ile Gln Met Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu 
            500                 505                 510         


Ala Gln Tyr Arg Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr 
        515                 520                 525             


Leu Gln Arg Arg Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His 
    530                 535                 540                 


Glu Tyr Thr Asn Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp 
545                 550                 555                 560 


Gln Ser Pro Leu Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met 
                565                 570                 575     


Arg Glu Asp Ser Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln 
            580                 585                 590         


Gln Lys Ser Phe Arg 
        595         


<210>  20
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  phosphatase domain of PTPN11

<400>  20

Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln Gln Glu Cys Lys Leu Leu 
1               5                   10                  15      


Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu Asn Lys Asn Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Thr Arg Val Val Leu His Asp 
        35                  40                  45              


Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr Ile Asn Ala Asn Ile Ile 
    50                  55                  60                  


Met Pro Glu Phe Glu Thr Lys Cys Asn Asn Ser Lys Pro Lys Lys Ser 
65                  70                  75                  80  


Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn Thr Val Asn Asp Phe Trp 
                85                  90                  95      


Arg Met Val Phe Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Lys 
            100                 105                 110         


Glu Val Glu Arg Gly Lys Ser Lys Cys Val Lys Tyr Trp Pro Asp Glu 
        115                 120                 125             


Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg Val Arg Asn Val Lys Glu 
    130                 135                 140                 


Ser Ala Ala His Asp Tyr Thr Leu Arg Glu Leu Lys Leu Ser Lys Val 
145                 150                 155                 160 


Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu Arg Thr Val Trp Gln Tyr 
                165                 170                 175     


His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro Gly Gly 
            180                 185                 190         


Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser Ile Met 
        195                 200                 205             


Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Thr 
    210                 215                 220                 


Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg Glu Lys 
225                 230                 235                 240 


Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met Val Arg 
                245                 250                 255     


Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg Phe Ile 
            260                 265                 270         


Tyr Met Ala Val Gln His Tyr Ile Glu Thr Leu Gln Arg Arg Ile Glu 
        275                 280                 285             


Glu Glu Gln Lys Ser Lys Arg Lys Gly His Glu Tyr Thr Asn Ile Lys 
    290                 295                 300                 


Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp Gln Ser Pro Leu Pro Pro 
305                 310                 315                 320 


Cys Thr Pro Thr Pro Pro Cys Ala Glu Met Arg Glu Asp Ser Ala Arg 
                325                 330                 335     


Val Tyr Glu Asn Val Gly Leu Met Gln Gln Gln Lys Ser Phe Arg 
            340                 345                 350     


<210>  21
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E3 ubiquitin-protein ligase CHIP degradation motif

<400>  21

Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
1               5                   10                  15      


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
            20                  25                  30          


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
        35                  40                  45              


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
    50                  55                  60                  


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
65                  70                  75                  80  


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
                85                  90                  95      


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
            100                 105                 110         


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
        115                 120                 125             


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
    130                 135                 140                 


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
145                 150                 155                 160 


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val 
                165                 170             


<210>  22
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Simb degradation motif

<400>  22

Met Met Lys Met Glu Thr Asp Lys Ile Met Asp Glu Thr Asn Ser Asn 
1               5                   10                  15      


Ala Gln Ala Phe Thr Thr Thr Met Leu Tyr Asp Pro Val Arg Lys Lys 
            20                  25                  30          


Asp Ser Ser Pro Thr Tyr Gln Thr Glu Arg Glu Leu Cys Phe Gln Tyr 
        35                  40                  45              


Phe Thr Gln Trp Ser Glu Ser Gly Gln Val Asp Phe Val Glu His Leu 
    50                  55                  60                  


Leu Ser Arg Met Cys His Tyr Gln His Gly Gln Ile Asn Ala Tyr Leu 
65                  70                  75                  80  


Lys Pro Met Leu Gln Arg Asp Phe Ile Thr Leu Leu Pro Ile Lys Gly 
                85                  90                  95      


Leu Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Glu Ser 
            100                 105                 110         


Leu Lys Ser Ser Glu Leu Val Cys Lys Glu Trp Leu Arg Val Ile Ser 
        115                 120                 125             


Glu Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Lys Val Arg Thr Asp 
    130                 135                 140                 


Ser Leu Trp Arg Gly Leu Ala Glu Arg Arg Asn Trp Met Gln Tyr Leu 
145                 150                 155                 160 


Phe Lys Pro Arg Pro Gly Gln Thr Gln Arg Pro His Ser Phe His Arg 
                165                 170                 175     


Glu Leu Phe Pro Lys Ile Met Asn Asp Ile Asp Ser Ile Glu Asn Asn 
            180                 185                 190         


Trp Arg Thr Gly Arg His 
        195             


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEST domain sequence

<400>  23

His Gly Phe Pro Pro Glu Val Glu Glu Gln Asp Asp Gly Thr Leu Pro 
1               5                   10                  15      


Met Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys 
            20                  25                  30          


Ala Ser Ala Arg Ile Asn Val 
        35                  


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nuclear factor of activated T cells (NFAT) response element

<400>  24
ggaggaaaaa ctgtttcata cagaaggcgt                                        30


<210>  25
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
        195                 200                 205             


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
    210                 215                 220                 


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
225                 230                 235                 240 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
                245                 250                 255     


Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 
            260                 265                 270         


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
        275                 280                 285             


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
    290                 295                 300                 


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
305                 310                 315                 320 


Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 
                325                 330                 335     


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
        355                 360                 365             


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
    370                 375                 380                 


Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 
385                 390                 395                 400 


Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 
                405                 410                 415     


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
            420                 425                 430         


Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 
        435                 440                 445             


Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 
    450                 455                 460                 


Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 
465                 470                 475                 480 


<210>  26
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP2-binding FN3-based binding domain, Nsa2

<400>  26

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly Tyr Tyr Ala Tyr Phe Gln Glu Phe Glu 
        35                  40                  45              


Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
    50                  55                  60                  


Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Tyr Tyr Gly Tyr Tyr Gly 
65                  70                  75                  80  


Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  


<210>  27
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP2-binding FN3-based binding domain, Nsa4

<400>  27

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly Tyr Tyr Ala Tyr Phe Gln Glu Phe Glu 
        35                  40                  45              


Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
    50                  55                  60                  


Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Tyr Tyr Gly Tyr Tyr Gly 
65                  70                  75                  80  


Asn Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  


<210>  28
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP2-binding FN3-based binding domain, Cs1

<400>  28

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly Tyr Trp Pro Tyr Tyr Trp Gln Glu Phe 
        35                  40                  45              


Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Asp Ser Tyr 
65                  70                  75                  80  


Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90              


<210>  29
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP2-binding FN3-based binding domain, Cs3

<400>  29

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe 
        35                  40                  45              


Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr 
65                  70                  75                  80  


Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90              


<210>  30
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XIAP's RING domain degradation motif

<400>  30

Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro Cys 
1               5                   10                  15      


Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys Cys 
            20                  25                  30          


Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met Ser 
        35                  40                  45              


<210>  31
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  e4B's U-box degradation motif

<400>  31

Asp Ala Pro Asp Glu Phe Arg Asp Pro Leu Met Asp Thr Leu Met Thr 
1               5                   10                  15      


Asp Pro Val Arg Leu Pro Ser Gly Thr Ile Met Asp Arg Ser Ile Ile 
            20                  25                  30          


Leu Arg His Leu Leu Asn Ser Pro Thr Asp Pro Phe Asn Arg Gln Thr 
        35                  40                  45              


Leu Thr Glu Ser Met Leu Glu Pro Val Pro Glu Leu Lys Glu Gln Ile 
    50                  55                  60                  


Gln Ala Trp Met Arg Glu Lys Gln Asn Ser Asp His 
65                  70                  75      


<210>  32
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Notch1's PEST motif degradation motif

<400>  32

His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser 
1               5                   10                  15      


Ser Ser Pro His Ser Asn Val Ser Asp Trp Ser Glu Gly Val Ser Ser 
            20                  25                  30          


Pro Pro Thr Ser Met Gln Ser Gln Ile Ala Arg Ile Pro Glu Ala Phe 
        35                  40                  45              


Lys 
    


<210>  33
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP2-binding FN3-based binding domain, Cs4

<400>  33

Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
1               5                   10                  15      


Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            20                  25                  30          


Ile Thr Tyr Gly Glu Thr Gly Tyr Trp Pro Tyr Tyr Trp Gln Glu Phe 
        35                  40                  45              


Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly His Tyr Asn Ser Tyr 
65                  70                  75                  80  


Tyr Tyr Ser Tyr Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90              


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence motif

<400>  34

Lys Asp Glu Leu 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM (immunoreceptor tyrosine-based activation motif)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Leu or Ile

<400>  35

Tyr Xaa Xaa Xaa 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic amino acid furin target sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Arg or Lys

<400>  36

Arg Xaa Xaa Arg 
1               


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Tobacco Etch Virus (TEV) cleavage site

<400>  37

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


