                         SEQUENCE LISTING

<110>  Universitt Ulm
 
<120>  Complement Inhibitors and Uses thereof

<130>  UU15304PC

<150>  EP18179269.8
<151>  2018-06-22

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  246
<212>  PRT
<213>  Artificial

<220>
<223>  CCP 1-4 of human Factor H

<400>  1

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu 
                245     


<210>  2
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  CCP 19 and 20 of human Factor H

<400>  2

Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe 
1               5                   10                  15      


Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln 
            20                  25                  30          


Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly 
        35                  40                  45              


Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg 
    50                  55                  60                  


Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln 
65                  70                  75                  80  


Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg 
                85                  90                  95      


Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp 
            100                 105                 110         


Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
        115                 120                 


<210>  3
<211>  209
<212>  PRT
<213>  Artificial

<220>
<223>  Fc receptor binding module (short version)

<400>  3

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


Ser 
    


<210>  4
<211>  384
<212>  PRT
<213>  Artificial

<220>
<223>  miniFH variant 1

<400>  4

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp 
            260                 265                 270         


Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu 
        275                 280                 285             


Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr 
    290                 295                 300                 


Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys 
305                 310                 315                 320 


Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp 
                325                 330                 335     


Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe 
            340                 345                 350         


Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg 
        355                 360                 365             


Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
    370                 375                 380                 


<210>  5
<211>  371
<212>  PRT
<213>  Artificial

<220>
<223>  miniFH variant 2

<400>  5

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
                245                 250                 255     


Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
            260                 265                 270         


Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
        275                 280                 285             


Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
    290                 295                 300                 


His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
305                 310                 315                 320 


Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
                325                 330                 335     


Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
            340                 345                 350         


Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
        355                 360                 365             


Ala Lys Arg 
    370     


<210>  6
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  miniFH variant 3

<400>  6

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Ala Gly Gly Gly Gly Gly Gly Gly Gly Lys 
                245                 250                 255     


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
            260                 265                 270         


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
        275                 280                 285             


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
    290                 295                 300                 


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
305                 310                 315                 320 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
                325                 330                 335     


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
            340                 345                 350         


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
        355                 360                 365             


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
    370                 375                 


<210>  7
<211>  376
<212>  PRT
<213>  Artificial

<220>
<223>  miniFH variant 4

<400>  7

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Ala Gly Gly Gly Gly Gly Lys Cys Gly Pro 
                245                 250                 255     


Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
            260                 265                 270         


Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
        275                 280                 285             


Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
    290                 295                 300                 


Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
305                 310                 315                 320 


Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
                325                 330                 335     


Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
            340                 345                 350         


Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
        355                 360                 365             


Glu Tyr Pro Thr Cys Ala Lys Arg 
    370                 375     


<210>  8
<211>  603
<212>  PRT
<213>  Artificial

<220>
<223>  FC-miniFH, short version

<400>  8

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


Ser Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Glu Asp Cys Asn Glu 
    210                 215                 220                 


Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp 
225                 230                 235                 240 


Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly 
                245                 250                 255     


Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys Arg Lys Gly Glu Trp 
            260                 265                 270         


Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His 
        275                 280                 285             


Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val 
    290                 295                 300                 


Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln 
305                 310                 315                 320 


Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr 
                325                 330                 335     


Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala 
            340                 345                 350         


Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu 
        355                 360                 365             


Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys 
    370                 375                 380                 


Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser 
385                 390                 395                 400 


Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val 
                405                 410                 415     


Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu 
            420                 425                 430         


Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly 
        435                 440                 445             


Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu 
    450                 455                 460                 


Glu Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys 
465                 470                 475                 480 


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
                485                 490                 495     


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
            500                 505                 510         


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
        515                 520                 525             


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
    530                 535                 540                 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
                565                 570                 575     


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
            580                 585                 590         


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
        595                 600             


<210>  9
<211>  1827
<212>  DNA
<213>  Artificial

<220>
<223>  Fc-miniFH short, encoding

<400>  9
ggtggtccat ctgttttttt gttcccacca aagccaaagg acactttgat gatctccaga     60

actccagagg ttacttgtgt tgttgttgac gtttctcacg aggacccaga ggttaagttc    120

aactggtacg ttgacggtgt tgaggttcac aacgctaaga ctaagccaag agaggaacag    180

taccagtcca cttacagagt tgtttccgtt ttgactgtct tgcaccagga ctggttgaac    240

ggtaaagagt acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact    300

atctccaagg ctaagggtca gccaagagag ccacaagttt acactttgcc accatccaga    360

gaagagatga ctaagaacca ggtttccttg acttgtttgg ttaagggttt ctacccatcc    420

gacattgctg ttgaatggga gtctaacggt cagccagaga acaactacaa gactactcca    480

ccagttttgg actccgacgg ttcattcttc ttgtactcca agttgactgt tgacaagtcc    540

agatggcagc agggtaacgt tttctcctgt tctgttatgc acgaggctct tcacaaccac    600

tacactcaaa agtccttgtc cttgtctcca ggtggtggtg gtggaggtgg tcccggggag    660

gactgtaatg aattgccacc aagaagaaac actgagatct tgactggttc ctggtccgac    720

caaacttacc cagaaggtac tcaggctatc tacaagtgta gaccaggtta cagatccttg    780

ggtaacatca tcatggtctg tagaaagggt gagtgggttg ctttgaaccc attgagaaag    840

tgtcagaaaa gaccatgtgg tcacccaggt gatactccat tcggtacttt cactttgact    900

ggtggtaacg ttttcgagta cggtgttaag gctgtttaca cttgtaacga gggttaccag    960

ttgttgggtg agatcaacta cagagagtgt gacactgacg gttggactaa cgacatccca   1020

atctgtgagg ttgttaagtg tttgccagtt actgctccag agaacggtaa gatcgtttcc   1080

tctgctatgg aaccagacag agagtaccac ttcggtcagg ctgttagatt cgtctgtaac   1140

tccggttaca agatcgaggg tgacgaagaa atgcactgtt ctgatgacgg tttctggtcc   1200

aaagaaaagc caaagtgtgt tgagatctcc tgtaagtccc cagacgttat taacggttcc   1260

ccaatctccc agaagatcat ctacaaagag aacgagagat tccagtacaa gtgtaacatg   1320

ggttacgagt actccgagag aggtgacgct gtctgtactg aatctggttg gagaccattg   1380

ccatcctgtg aagaggccgg tggtggtgga ggtggaggtg gtggtggcgg aggtggtaaa   1440

tgtggtcccc caccaccaat tgacaacggt gacattactt ccttcccatt gtccgtttac   1500

gctccagctt cttccgttga gtaccagtgt cagaacttgt accagttgga gggtaacaag   1560

agaatcactt gtagaaacgg tcagtggtcc gagccaccaa aatgtctgca cccatgtgtt   1620

atctccagag aaatcatgga aaactacaac attgctttga gatggactgc taagcagaag   1680

ttgtactcca gaactggtga gtccgttgag ttcgtctgta agagaggtta cagattgtcc   1740

tccagatccc acactttgag aactacttgt tgggacggaa agcttgagta cccaacttgt   1800

gctaagagat aataatctag aacaaaa                                       1827


<210>  10
<211>  610
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-minFH long

<400>  10

Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            20                  25                  30          


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        35                  40                  45              


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    50                  55                  60                  


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
65                  70                  75                  80  


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                85                  90                  95      


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        115                 120                 125             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    130                 135                 140                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                165                 170                 175     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            180                 185                 190         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        195                 200                 205             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Gly Gly 
    210                 215                 220                 


Pro Gly Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
225                 230                 235                 240 


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
                245                 250                 255     


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
            260                 265                 270         


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
        275                 280                 285             


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
    290                 295                 300                 


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
305                 310                 315                 320 


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
                325                 330                 335     


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
            340                 345                 350         


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
        355                 360                 365             


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
    370                 375                 380                 


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
385                 390                 395                 400 


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
                405                 410                 415     


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
            420                 425                 430         


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
        435                 440                 445             


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
    450                 455                 460                 


Arg Pro Leu Pro Ser Cys Glu Glu Ala Gly Gly Gly Gly Gly Gly Gly 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn 
                485                 490                 495     


Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser 
            500                 505                 510         


Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg 
        515                 520                 525             


Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His 
    530                 535                 540                 


Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu 
545                 550                 555                 560 


Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val 
                565                 570                 575     


Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr 
            580                 585                 590         


Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala 
        595                 600                 605             


Lys Arg 
    610 


<210>  11
<211>  1842
<212>  DNA
<213>  Artificial

<220>
<223>  Fc-miniFH long, encoding

<400>  11
tgtccagctc cagagttgtt gggtggtcca tctgtttttt tgttcccacc aaagccaaag     60

gacactttga tgatctccag aactccagag gttacttgtg ttgttgttga cgtttctcac    120

gaggacccag aggttaagtt caactggtac gttgacggtg ttgaggttca caacgctaag    180

actaagccaa gagaggaaca gtaccagtcc acttacagag ttgtttccgt tttgactgtc    240

ttgcaccagg actggttgaa cggtaaagag tacaagtgta aggtttccaa caaggctttg    300

ccagctccaa tcgaaaagac tatctccaag gctaagggtc agccaagaga gccacaagtt    360

tacactttgc caccatccag agaagagatg actaagaacc aggtttcctt gacttgtttg    420

gttaagggtt tctacccatc cgacattgct gttgaatggg agtctaacgg tcagccagag    480

aacaactaca agactactcc accagttttg gactccgacg gttcattctt cttgtactcc    540

aagttgactg ttgacaagtc cagatggcag cagggtaacg ttttctcctg ttctgttatg    600

cacgaggctc ttcacaacca ctacactcaa aagtccttgt ccttgtctcc aggtggtggt    660

ggtggaggtg gtcccgggga ggactgtaat gaattgccac caagaagaaa cactgagatc    720

ttgactggtt cctggtccga ccaaacttac ccagaaggta ctcaggctat ctacaagtgt    780

agaccaggtt acagatcctt gggtaacatc atcatggtct gtagaaaggg tgagtgggtt    840

gctttgaacc cattgagaaa gtgtcagaaa agaccatgtg gtcacccagg tgatactcca    900

ttcggtactt tcactttgac tggtggtaac gttttcgagt acggtgttaa ggctgtttac    960

acttgtaacg agggttacca gttgttgggt gagatcaact acagagagtg tgacactgac   1020

ggttggacta acgacatccc aatctgtgag gttgttaagt gtttgccagt tactgctcca   1080

gagaacggta agatcgtttc ctctgctatg gaaccagaca gagagtacca cttcggtcag   1140

gctgttagat tcgtctgtaa ctccggttac aagatcgagg gtgacgaaga aatgcactgt   1200

tctgatgacg gtttctggtc caaagaaaag ccaaagtgtg ttgagatctc ctgtaagtcc   1260

ccagacgtta ttaacggttc cccaatctcc cagaagatca tctacaaaga gaacgagaga   1320

ttccagtaca agtgtaacat gggttacgag tactccgaga gaggtgacgc tgtctgtact   1380

gaatctggtt ggagaccatt gccatcctgt gaagaggccg gtggtggtgg aggtggaggt   1440

ggtggtggcg gaggtggtaa atgtggtccc ccaccaccaa ttgacaacgg tgacattact   1500

tccttcccat tgtccgttta cgctccagct tcttccgttg agtaccagtg tcagaacttg   1560

taccagttgg agggtaacaa gagaatcact tgtagaaacg gtcagtggtc cgagccacca   1620

aaatgtctgc acccatgtgt tatctccaga gaaatcatgg aaaactacaa cattgctttg   1680

agatggactg ctaagcagaa gttgtactcc agaactggtg agtccgttga gttcgtctgt   1740

aagagaggtt acagattgtc ctccagatcc cacactttga gaactacttg ttgggacgga   1800

aagcttgagt acccaacttg tgctaagaga taataatcta ga                      1842


<210>  12
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Fc receptor binding module long

<400>  12

Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            20                  25                  30          


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        35                  40                  45              


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    50                  55                  60                  


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
65                  70                  75                  80  


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                85                  90                  95      


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        115                 120                 125             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    130                 135                 140                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                165                 170                 175     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            180                 185                 190         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        195                 200                 205             


Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215     


<210>  13
<211>  615
<212>  PRT
<213>  Artificial

<220>
<223>  miniFH-Fc

<400>  13

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp 
            260                 265                 270         


Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu 
        275                 280                 285             


Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr 
    290                 295                 300                 


Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys 
305                 310                 315                 320 


Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp 
                325                 330                 335     


Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe 
            340                 345                 350         


Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg 
        355                 360                 365             


Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Gly Pro 
    370                 375                 380                 


Gly Gly Gly Gly Gly Pro Gly Cys Pro Ala Pro Glu Leu Leu Gly Gly 
385                 390                 395                 400 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                405                 410                 415     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            420                 425                 430         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        435                 440                 445             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg 
    450                 455                 460                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
465                 470                 475                 480 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                485                 490                 495     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            500                 505                 510         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        515                 520                 525             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    530                 535                 540                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
545                 550                 555                 560 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                565                 570                 575     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            580                 585                 590         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        595                 600                 605             


Gly Gly Gly Gly Gly Gly Gly 
    610                 615 


<210>  14
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  N-termminal extension 1

<400>  14

Glu Ala Glu Ala Ala Gly 
1               5       


<210>  15
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  N-terminal extension 2

<400>  15

Glu Ala Ala Gly 
1               


<210>  16
<211>  2
<212>  PRT
<213>  Artificial

<220>
<223>  N-terminal extension 3

<400>  16

Ala Gly 
1       


<210>  17
<211>  479
<212>  PRT
<213>  Artificial

<220>
<223>  Fig. 5

<400>  17

Ala Gly Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        35                  40                  45              


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    50                  55                  60                  


Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                85                  90                  95      


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        115                 120                 125             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    130                 135                 140                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
145                 150                 155                 160 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                165                 170                 175     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Pro Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln 
225                 230                 235                 240 


Pro Ala Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr 
                245                 250                 255     


Tyr Lys Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser 
            260                 265                 270         


Val Ile Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys 
        275                 280                 285             


Asn Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys 
    290                 295                 300                 


Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu 
305                 310                 315                 320 


Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys 
                325                 330                 335     


Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys 
            340                 345                 350         


Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile 
        355                 360                 365             


Asp Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys 
    370                 375                 380                 


Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile 
385                 390                 395                 400 


Ser Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu 
                405                 410                 415     


Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly 
            420                 425                 430         


Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn 
        435                 440                 445             


Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn 
    450                 455                 460                 


Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly 
465                 470                 475                 


<210>  18
<211>  482
<212>  PRT
<213>  Artificial

<220>
<223>  Fig. 5

<400>  18

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Pro Gly Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
465                 470                 475                 480 


Gly Gly 
        


