                         SEQUENCE LISTING

<110>  Ͽѧ
 
<120>  ںϵE-ճ-FcVE-ճ-FcVEGF-Fc;

<130>  IP190245

<160>  111   

<170>  PatentIn version 3.3

<210>  1
<211>  31
<212>  DNA
<213>  ˹

<400>  1
ccggatatca tgcagaggct catgatgctc c                                    31


<210>  2
<211>  26
<212>  DNA
<213>  ˹

<400>  2
aagcggccgc tctgggcggc catatc                                          26


<210>  3
<211>  692
<212>  PRT
<213>  ˹

<400>  3

Asp Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser 
1               5                   10                  15      


Leu Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn 
            20                  25                  30          


Ala Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val 
        35                  40                  45              


Asp Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu 
    50                  55                  60                  


Asn Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr 
65                  70                  75                  80  


Gly Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp 
                85                  90                  95      


Val Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser 
            100                 105                 110         


Val Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala 
        115                 120                 125             


Val Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr 
    130                 135                 140                 


Gln Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg 
145                 150                 155                 160 


Ile Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr 
                165                 170                 175     


Glu Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser 
            180                 185                 190         


Gly Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe 
        195                 200                 205             


Pro Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr 
    210                 215                 220                 


Arg Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu 
225                 230                 235                 240 


Pro Gln Asn Arg Met Thr Lys Tyr Ser Pro Pro Ala Gly Asn Arg Ala 
                245                 250                 255     


Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu Pro Pro Ile Phe Gln 
            260                 265                 270         


Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn Gln Lys Lys Pro Leu 
        275                 280                 285             


Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala Ala Arg His Ser Ile 
    290                 295                 300                 


Gly Tyr Ser Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys Glu Leu Asp 
305                 310                 315                 320 


Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln Val His Ile 
                325                 330                 335     


Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala Lys Pro Tyr 
            340                 345                 350         


Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu Val Leu Gln 
        355                 360                 365             


Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val Lys Phe Lys 
    370                 375                 380                 


Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp Asn His Asp 
385                 390                 395                 400 


Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp Arg Glu His 
                405                 410                 415     


Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn Gly Met Pro 
            420                 425                 430         


Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys Lys Cys Asn 
        435                 440                 445             


Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala Gln Ser Gly 
    450                 455                 460                 


Arg Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
465                 470                 475                 480 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                485                 490                 495     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            500                 505                 510         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        515                 520                 525             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    530                 535                 540                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
545                 550                 555                 560 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                565                 570                 575     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            580                 585                 590         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        595                 600                 605             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    610                 615                 620                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
625                 630                 635                 640 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                645                 650                 655     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            660                 665                 670         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        675                 680                 685             


Ser Pro Gly Lys 
    690         


<210>  4
<211>  227
<212>  PRT
<213>  ˹

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  465
<212>  PRT
<213>  ˹

<400>  5

Asp Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser 
1               5                   10                  15      


Leu Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn 
            20                  25                  30          


Ala Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val 
        35                  40                  45              


Asp Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu 
    50                  55                  60                  


Asn Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr 
65                  70                  75                  80  


Gly Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp 
                85                  90                  95      


Val Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser 
            100                 105                 110         


Val Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala 
        115                 120                 125             


Val Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr 
    130                 135                 140                 


Gln Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg 
145                 150                 155                 160 


Ile Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr 
                165                 170                 175     


Glu Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser 
            180                 185                 190         


Gly Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe 
        195                 200                 205             


Pro Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr 
    210                 215                 220                 


Arg Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu 
225                 230                 235                 240 


Pro Gln Asn Arg Met Thr Lys Tyr Ser Pro Pro Ala Gly Asn Arg Ala 
                245                 250                 255     


Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu Pro Pro Ile Phe Gln 
            260                 265                 270         


Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn Gln Lys Lys Pro Leu 
        275                 280                 285             


Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala Ala Arg His Ser Ile 
    290                 295                 300                 


Gly Tyr Ser Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys Glu Leu Asp 
305                 310                 315                 320 


Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln Val His Ile 
                325                 330                 335     


Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala Lys Pro Tyr 
            340                 345                 350         


Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu Val Leu Gln 
        355                 360                 365             


Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val Lys Phe Lys 
    370                 375                 380                 


Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp Asn His Asp 
385                 390                 395                 400 


Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp Arg Glu His 
                405                 410                 415     


Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn Gly Met Pro 
            420                 425                 430         


Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys Lys Cys Asn 
        435                 440                 445             


Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala Gln Ser Gly 
    450                 455                 460                 


Arg 
465 


<210>  6
<211>  30
<212>  DNA
<213>  ˹

<400>  6
cgcaagctta tgggcccttg gagccgcagc                                      30


<210>  7
<211>  32
<212>  DNA
<213>  ˹

<400>  7
ttgcggccgc aggcaggaat ttgcaatcct gc                                   32


<210>  8
<211>  917
<212>  PRT
<213>  ˹

<400>  8

Gln Glu Pro Glu Pro Cys His Pro Gly Phe Asp Ala Glu Ser Tyr Thr 
1               5                   10                  15      


Phe Thr Val Pro Arg Arg His Leu Glu Arg Gly Arg Val Leu Gly Arg 
            20                  25                  30          


Val Asn Phe Glu Asp Cys Thr Gly Arg Gln Arg Thr Ala Tyr Phe Ser 
        35                  40                  45              


Leu Asp Thr Arg Phe Lys Val Gly Thr Asp Gly Val Ile Thr Val Lys 
    50                  55                  60                  


Arg Pro Leu Arg Phe His Asn Pro Gln Ile His Phe Leu Val Tyr Ala 
65                  70                  75                  80  


Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr Lys Val Thr Leu Asn Thr 
                85                  90                  95      


Val Gly His His His Arg Pro Pro Pro His Gln Ala Ser Val Ser Gly 
            100                 105                 110         


Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn Ser Ser Pro Gly Leu Arg 
        115                 120                 125             


Arg Gln Lys Arg Asp Trp Val Ile Pro Pro Ile Ser Cys Pro Glu Asn 
    130                 135                 140                 


Glu Lys Gly Pro Phe Pro Lys Asn Leu Val Gln Ile Lys Ser Asn Lys 
145                 150                 155                 160 


Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile Thr Gly Gln Gly Ala Asp 
                165                 170                 175     


Thr Pro Pro Val Gly Val Phe Ile Ile Glu Arg Glu Thr Gly Trp Leu 
            180                 185                 190         


Lys Val Thr Glu Pro Leu Asp Arg Glu Arg Ile Ala Thr Tyr Thr Leu 
        195                 200                 205             


Phe Ser His Ala Val Ser Ser Asn Gly Asn Ala Val Glu Asp Pro Met 
    210                 215                 220                 


Glu Ile Leu Ile Thr Val Thr Asp Gln Asn Asp Asn Lys Pro Glu Phe 
225                 230                 235                 240 


Thr Gln Glu Val Phe Lys Gly Ser Val Met Glu Gly Ala Leu Pro Gly 
                245                 250                 255     


Thr Ser Val Met Glu Val Thr Ala Thr Asp Ala Asp Asp Asp Val Asn 
            260                 265                 270         


Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile Leu Ser Gln Asp Pro Glu 
        275                 280                 285             


Leu Pro Asp Lys Asn Met Phe Thr Ile Asn Arg Asn Thr Gly Val Ile 
    290                 295                 300                 


Ser Val Val Thr Thr Gly Leu Asp Arg Glu Ser Phe Pro Thr Tyr Thr 
305                 310                 315                 320 


Leu Val Val Gln Ala Ala Asp Leu Gln Gly Glu Gly Leu Ser Thr Thr 
                325                 330                 335     


Ala Thr Ala Val Ile Thr Val Thr Asp Thr Asn Asp Asn Pro Pro Ile 
            340                 345                 350         


Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val Pro Glu Asn Glu Ala Asn 
        355                 360                 365             


Val Val Ile Thr Thr Leu Lys Val Thr Asp Ala Asp Ala Pro Asn Thr 
    370                 375                 380                 


Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu Asn Asp Asp Gly Gly Gln 
385                 390                 395                 400 


Phe Val Val Thr Thr Asn Pro Val Asn Asn Asp Gly Ile Leu Lys Thr 
                405                 410                 415     


Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln Gln Tyr Ile Leu His Val 
            420                 425                 430         


Ala Val Thr Asn Val Val Pro Phe Glu Val Ser Leu Thr Thr Ser Thr 
        435                 440                 445             


Ala Thr Val Thr Val Asp Val Leu Asp Val Asn Glu Ala Pro Ile Phe 
    450                 455                 460                 


Val Pro Pro Glu Lys Arg Val Glu Val Ser Glu Asp Phe Gly Val Gly 
465                 470                 475                 480 


Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu Pro Asp Thr Phe Met Glu 
                485                 490                 495     


Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp Leu Glu 
            500                 505                 510         


Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu Asp Arg 
        515                 520                 525             


Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu Ile Ile 
    530                 535                 540                 


Ala Thr Asp Asn Gly Ser Pro Val Ala Thr Gly Thr Gly Thr Leu Leu 
545                 550                 555                 560 


Leu Ile Leu Ser Asp Val Asn Asp Asn Ala Pro Ile Pro Glu Pro Arg 
                565                 570                 575     


Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys Pro Gln Val Ile Asn Ile 
            580                 585                 590         


Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser Pro Phe Thr Ala Glu Leu 
        595                 600                 605             


Thr His Gly Ala Ser Ala Asn Trp Thr Ile Gln Tyr Asn Asp Pro Thr 
    610                 615                 620                 


Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val Gly Asp 
625                 630                 635                 640 


Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp Gln Val 
                645                 650                 655     


Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala Gly Val 
            660                 665                 670         


Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Cys 
        675                 680                 685             


Gly Arg Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    690                 695                 700                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
705                 710                 715                 720 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                725                 730                 735     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            740                 745                 750         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        755                 760                 765             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    770                 775                 780                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
785                 790                 795                 800 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                805                 810                 815     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            820                 825                 830         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        835                 840                 845             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    850                 855                 860                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
865                 870                 875                 880 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                885                 890                 895     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            900                 905                 910         


Leu Ser Pro Gly Lys 
        915         


<210>  9
<211>  690
<212>  PRT
<213>  ˹

<400>  9

Gln Glu Pro Glu Pro Cys His Pro Gly Phe Asp Ala Glu Ser Tyr Thr 
1               5                   10                  15      


Phe Thr Val Pro Arg Arg His Leu Glu Arg Gly Arg Val Leu Gly Arg 
            20                  25                  30          


Val Asn Phe Glu Asp Cys Thr Gly Arg Gln Arg Thr Ala Tyr Phe Ser 
        35                  40                  45              


Leu Asp Thr Arg Phe Lys Val Gly Thr Asp Gly Val Ile Thr Val Lys 
    50                  55                  60                  


Arg Pro Leu Arg Phe His Asn Pro Gln Ile His Phe Leu Val Tyr Ala 
65                  70                  75                  80  


Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr Lys Val Thr Leu Asn Thr 
                85                  90                  95      


Val Gly His His His Arg Pro Pro Pro His Gln Ala Ser Val Ser Gly 
            100                 105                 110         


Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn Ser Ser Pro Gly Leu Arg 
        115                 120                 125             


Arg Gln Lys Arg Asp Trp Val Ile Pro Pro Ile Ser Cys Pro Glu Asn 
    130                 135                 140                 


Glu Lys Gly Pro Phe Pro Lys Asn Leu Val Gln Ile Lys Ser Asn Lys 
145                 150                 155                 160 


Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile Thr Gly Gln Gly Ala Asp 
                165                 170                 175     


Thr Pro Pro Val Gly Val Phe Ile Ile Glu Arg Glu Thr Gly Trp Leu 
            180                 185                 190         


Lys Val Thr Glu Pro Leu Asp Arg Glu Arg Ile Ala Thr Tyr Thr Leu 
        195                 200                 205             


Phe Ser His Ala Val Ser Ser Asn Gly Asn Ala Val Glu Asp Pro Met 
    210                 215                 220                 


Glu Ile Leu Ile Thr Val Thr Asp Gln Asn Asp Asn Lys Pro Glu Phe 
225                 230                 235                 240 


Thr Gln Glu Val Phe Lys Gly Ser Val Met Glu Gly Ala Leu Pro Gly 
                245                 250                 255     


Thr Ser Val Met Glu Val Thr Ala Thr Asp Ala Asp Asp Asp Val Asn 
            260                 265                 270         


Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile Leu Ser Gln Asp Pro Glu 
        275                 280                 285             


Leu Pro Asp Lys Asn Met Phe Thr Ile Asn Arg Asn Thr Gly Val Ile 
    290                 295                 300                 


Ser Val Val Thr Thr Gly Leu Asp Arg Glu Ser Phe Pro Thr Tyr Thr 
305                 310                 315                 320 


Leu Val Val Gln Ala Ala Asp Leu Gln Gly Glu Gly Leu Ser Thr Thr 
                325                 330                 335     


Ala Thr Ala Val Ile Thr Val Thr Asp Thr Asn Asp Asn Pro Pro Ile 
            340                 345                 350         


Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val Pro Glu Asn Glu Ala Asn 
        355                 360                 365             


Val Val Ile Thr Thr Leu Lys Val Thr Asp Ala Asp Ala Pro Asn Thr 
    370                 375                 380                 


Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu Asn Asp Asp Gly Gly Gln 
385                 390                 395                 400 


Phe Val Val Thr Thr Asn Pro Val Asn Asn Asp Gly Ile Leu Lys Thr 
                405                 410                 415     


Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln Gln Tyr Ile Leu His Val 
            420                 425                 430         


Ala Val Thr Asn Val Val Pro Phe Glu Val Ser Leu Thr Thr Ser Thr 
        435                 440                 445             


Ala Thr Val Thr Val Asp Val Leu Asp Val Asn Glu Ala Pro Ile Phe 
    450                 455                 460                 


Val Pro Pro Glu Lys Arg Val Glu Val Ser Glu Asp Phe Gly Val Gly 
465                 470                 475                 480 


Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu Pro Asp Thr Phe Met Glu 
                485                 490                 495     


Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp Leu Glu 
            500                 505                 510         


Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu Asp Arg 
        515                 520                 525             


Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu Ile Ile 
    530                 535                 540                 


Ala Thr Asp Asn Gly Ser Pro Val Ala Thr Gly Thr Gly Thr Leu Leu 
545                 550                 555                 560 


Leu Ile Leu Ser Asp Val Asn Asp Asn Ala Pro Ile Pro Glu Pro Arg 
                565                 570                 575     


Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys Pro Gln Val Ile Asn Ile 
            580                 585                 590         


Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser Pro Phe Thr Ala Glu Leu 
        595                 600                 605             


Thr His Gly Ala Ser Ala Asn Trp Thr Ile Gln Tyr Asn Asp Pro Thr 
    610                 615                 620                 


Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val Gly Asp 
625                 630                 635                 640 


Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp Gln Val 
                645                 650                 655     


Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala Gly Val 
            660                 665                 670         


Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Cys 
        675                 680                 685             


Gly Arg 
    690 


<210>  10
<211>  22
<212>  DNA
<213>  ˹

<400>  10
cagcaacaat tcctggcgat ac                                              22


<210>  11
<211>  21
<212>  DNA
<213>  ˹

<400>  11
gctaaggcga aagccctcaa t                                               21


<210>  12
<211>  20
<212>  DNA
<213>  ˹

<400>  12
ttccaaagat gtagccgccc                                                 20


<210>  13
<211>  21
<212>  DNA
<213>  ˹

<400>  13
gttgggtcag gggtggttat t                                               21


<210>  14
<211>  20
<212>  DNA
<213>  ˹

<400>  14
aagaagggct cgtgtgacag                                                 20


<210>  15
<211>  20
<212>  DNA
<213>  ˹

<400>  15
ggaagggtta ccagttgggg                                                 20


<210>  16
<211>  20
<212>  DNA
<213>  ˹

<400>  16
cctggatgcc atcaaagtct                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  ˹

<400>  17
tcttgtcctt ggggttcttg                                                 20


<210>  18
<211>  13
<212>  DNA
<213>  ˹

<400>  18
atgtgaggat ggg                                                        13


<210>  19
<211>  14
<212>  DNA
<213>  ˹

<400>  19
aaagacattt tcct                                                       14


<210>  20
<211>  20
<212>  DNA
<213>  ˹

<400>  20
aaacatatct gcggaggatc                                                 20


<210>  21
<211>  20
<212>  DNA
<213>  ˹

<400>  21
acgatttgga atggcacatc                                                 20


<210>  22
<211>  20
<212>  DNA
<213>  ˹

<400>  22
ctgaatgtcc cctgtcccac                                                 20


<210>  23
<211>  20
<212>  DNA
<213>  ˹

<400>  23
ggttgcattg acccatctgc                                                 20


<210>  24
<211>  20
<212>  DNA
<213>  ˹

<400>  24
gagggcagaa tcatcacgaa                                                 20


<210>  25
<211>  20
<212>  DNA
<213>  ˹

<400>  25
gggaacgctc caggacttat                                                 20


<210>  26
<211>  395
<212>  PRT
<213>  ˹

<400>  26

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
        115                 120                 125             


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
    130                 135                 140                 


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
145                 150                 155                 160 


Asp Lys Pro Arg Arg Cys Gly Arg Asp Lys Thr His Thr Cys Pro Pro 
                165                 170                 175     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            180                 185                 190         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    210                 215                 220                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
225                 230                 235                 240 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                245                 250                 255     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            260                 265                 270         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        275                 280                 285             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    290                 295                 300                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
305                 310                 315                 320 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                325                 330                 335     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            340                 345                 350         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        355                 360                 365             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    370                 375                 380                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395 


<210>  27
<211>  24
<212>  DNA
<213>  ˹

<400>  27
ggggttctat ttgggaaggt gttc                                            24


<210>  28
<211>  20
<212>  DNA
<213>  ˹

<400>  28
ctcggaccac atccttctcg                                                 20


<210>  29
<211>  21
<212>  DNA
<213>  ˹

<400>  29
ggagcagcta ctatgcagag c                                               21


<210>  30
<211>  21
<212>  DNA
<213>  ˹

<400>  30
ggagcagcta ctatgcagag c                                               21


<210>  31
<211>  18
<212>  DNA
<213>  ˹

<400>  31
agggtgaaca taaatgcc                                                   18


<210>  32
<211>  19
<212>  DNA
<213>  ˹

<400>  32
cacttcccaa ggtgtaaaa                                                  19


<210>  33
<211>  24
<212>  DNA
<213>  ˹

<400>  33
aattgggagg catccagaac gaga                                            24


<210>  34
<211>  24
<212>  DNA
<213>  ˹

<400>  34
gggcattgtc cacagtattt gcga                                            24


<210>  35
<211>  20
<212>  DNA
<213>  ˹

<400>  35
agcttggtgg tggatgaaac                                                 20


<210>  36
<211>  20
<212>  DNA
<213>  ˹

<400>  36
ccctcttcag caaagcagac                                                 20


<210>  37
<211>  23
<212>  DNA
<213>  ˹

<400>  37
tgcaactctt cgtgaaacct atg                                             23


<210>  38
<211>  21
<212>  DNA
<213>  ˹

<400>  38
acatcaacct ctggtctcac c                                               21


<210>  39
<211>  23
<212>  DNA
<213>  ˹

<400>  39
aactcctact gattctcgat ggg                                             23


<210>  40
<211>  21
<212>  DNA
<213>  ˹

<400>  40
gtttccagca catgcaaaga c                                               21


<210>  41
<211>  23
<212>  DNA
<213>  ˹

<400>  41
ccctgctgtt cgatatacca atc                                             23


<210>  42
<211>  23
<212>  DNA
<213>  ˹

<400>  42
ccctgctgtt cgatatacca atc                                             23


<210>  43
<211>  22
<212>  DNA
<213>  ˹

<400>  43
gagagagacg ttcagcaact tc                                              22


<210>  44
<211>  22
<212>  DNA
<213>  ˹

<400>  44
gggactctag cgacttcatc tt                                              22


<210>  45
<211>  21
<212>  DNA
<213>  ˹

<400>  45
tgagtgacat gcgaagccaa t                                               21


<210>  46
<211>  22
<212>  DNA
<213>  ˹

<400>  46
ctcccggttc aattcttcag tc                                              22


<210>  47
<211>  20
<212>  DNA
<213>  ˹

<400>  47
tcagctcagc tcgtcctctt                                                 20


<210>  48
<211>  20
<212>  DNA
<213>  ˹

<400>  48
cctccttagg cagccttctt                                                 20


<210>  49
<211>  20
<212>  DNA
<213>  ˹

<400>  49
tcgctacagc ctttgcaatg                                                 20


<210>  50
<211>  21
<212>  DNA
<213>  ˹

<400>  50
ttgagggtac ggaggagttc c                                               21


<210>  51
<211>  20
<212>  DNA
<213>  ˹

<400>  51
aacggaaggc tcccttgatg                                                 20


<210>  52
<211>  20
<212>  DNA
<213>  ˹

<400>  52
aaaccagcct ctaaccaggc                                                 20


<210>  53
<211>  19
<212>  DNA
<213>  ˹

<400>  53
attaccccag gatatggag                                                  19


<210>  54
<211>  20
<212>  DNA
<213>  ˹

<400>  54
ccgtcaaggg aaagactacg                                                 20


<210>  55
<211>  24
<212>  DNA
<213>  ˹

<400>  55
ctgggcaccg actcatccga ctct                                            24


<210>  56
<211>  22
<212>  DNA
<213>  ˹

<400>  56
ggccccttcc tccctcttga ag                                              22


<210>  57
<211>  20
<212>  DNA
<213>  ˹

<400>  57
agcgagcatc ccccaaagtt                                                 20


<210>  58
<211>  20
<212>  DNA
<213>  ˹

<400>  58
gggcacgaag gctcatcatt                                                 20


<210>  59
<211>  20
<212>  DNA
<213>  ˹

<400>  59
ggaccagcta accaacgaca                                                 20


<210>  60
<211>  20
<212>  DNA
<213>  ˹

<400>  60
aaggtcaaga cgtgccagag                                                 20


<210>  61
<211>  20
<212>  DNA
<213>  ˹

<400>  61
ttctcggtct ggaggatgga                                                 20


<210>  62
<211>  21
<212>  DNA
<213>  ˹

<400>  62
cccacgccct gtttctttga a                                               21


<210>  63
<211>  20
<212>  DNA
<213>  ˹

<400>  63
ggcctagcga gtggttcttc                                                 20


<210>  64
<211>  20
<212>  DNA
<213>  ˹

<400>  64
cctgcagctc gctgtagtta                                                 20


<210>  65
<211>  22
<212>  DNA
<213>  ˹

<400>  65
cgaaggtcaa gctatgagga ca                                              22


<210>  66
<211>  21
<212>  DNA
<213>  ˹

<400>  66
ggccaagtac atcccagctt t                                               21


<210>  67
<211>  22
<212>  DNA
<213>  ˹

<400>  67
ccatgcaggc aacataaact tc                                              22


<210>  68
<211>  23
<212>  DNA
<213>  ˹

<400>  68
agggttgtaa cctgtgtaac aag                                             23


<210>  69
<211>  20
<212>  DNA
<213>  ˹

<400>  69
acagctcgtt gtaccgctgg                                                 20


<210>  70
<211>  20
<212>  DNA
<213>  ˹

<400>  70
agcttggggt ccaccactag                                                 20


<210>  71
<211>  20
<212>  DNA
<213>  ˹

<400>  71
agcagaacta acacacgggg                                                 20


<210>  72
<211>  20
<212>  DNA
<213>  ˹

<400>  72
agccagcttc ttgaagcgat                                                 20


<210>  73
<211>  20
<212>  DNA
<213>  ˹

<400>  73
gggaaaaccc gctctctcag                                                 20


<210>  74
<211>  20
<212>  DNA
<213>  ˹

<400>  74
cttccccgct gtgtgtgtta                                                 20


<210>  75
<211>  20
<212>  DNA
<213>  ˹

<400>  75
agcctttgtg aaccaacacc                                                 20


<210>  76
<211>  20
<212>  DNA
<213>  ˹

<400>  76
gctggtagag ggagcagatg                                                 20


<210>  77
<211>  19
<212>  DNA
<213>  ˹

<400>  77
gcctctcggt gtgacgagt                                                  19


<210>  78
<211>  20
<212>  DNA
<213>  ˹

<400>  78
aaaacgacgg caacaacgat                                                 20


<210>  79
<211>  20
<212>  DNA
<213>  ˹

<400>  79
cctgctcgga gacttaccac                                                 20


<210>  80
<211>  20
<212>  DNA
<213>  ˹

<400>  80
atcctggtca gggactggtt                                                 20


<210>  81
<211>  168
<212>  PRT
<213>  ˹

<400>  81

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
        115                 120                 125             


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
    130                 135                 140                 


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
145                 150                 155                 160 


Asp Lys Pro Arg Arg Cys Gly Arg 
                165             


<210>  82
<211>  20
<212>  DNA
<213>  ˹

<400>  82
ggcagctgtt cttatgtcct                                                 20


<210>  83
<211>  20
<212>  DNA
<213>  ˹

<400>  83
tggaactcat tgttttgtgg                                                 20


<210>  84
<211>  19
<212>  DNA
<213>  ˹

<400>  84
agcactatga tgccaaacc                                                  19


<210>  85
<211>  19
<212>  DNA
<213>  ˹

<400>  85
caagtggtga cctggaaag                                                  19


<210>  86
<211>  21
<212>  DNA
<213>  ˹

<400>  86
ctctgcgtca acgctagtgc c                                               21


<210>  87
<211>  24
<212>  DNA
<213>  ˹

<400>  87
cggaggagaa gttctgggta tctg                                            24


<210>  88
<211>  17
<212>  DNA
<213>  ˹

<400>  88
ctctgccgcc cttctgt                                                    17


<210>  89
<211>  18
<212>  DNA
<213>  ˹

<400>  89
cggagtttgg gtttgctt                                                   18


<210>  90
<211>  21
<212>  DNA
<213>  ˹

<400>  90
catactccaa acctttccac c                                               21


<210>  91
<211>  21
<212>  DNA
<213>  ˹

<400>  91
aaacttctcc acaaccctct g                                               21


<210>  92
<211>  6
<212>  PRT
<213>  ˹

<400>  92

Cys Gly Arg Gly Asp Ser 
1               5       


<210>  93
<211>  7
<212>  PRT
<213>  ˹

<400>  93

Cys His Trp Arg Gly Trp Val 
1               5           


<210>  94
<211>  6
<212>  PRT
<213>  ˹

<400>  94

His Tyr Phe Lys Phe Asp 
1               5       


<210>  95
<211>  6
<212>  PRT
<213>  ˹

<400>  95

His Phe Arg Arg His Leu 
1               5       


<210>  96
<211>  8
<212>  PRT
<213>  ˹

<400>  96

Phe Tyr Trp His Cys Leu Asp Glu 
1               5               


<210>  97
<211>  14
<212>  PRT
<213>  ˹

<400>  97

Cys Arg Gly Asp Pro Gln Gly Ile Trp Gly Gln Asp Arg Cys 
1               5                   10                  


<210>  98
<211>  20
<212>  DNA
<213>  ˹

<400>  98
caccatctgt cgcttcgagg                                                 20


<210>  99
<211>  22
<212>  DNA
<213>  ˹

<400>  99
agggtctccg atttgcatat ct                                              22


<210>  100
<211>  21
<212>  DNA
<213>  ˹

<400>  100
tccgactgga gcagctacta c                                               21


<210>  101
<211>  19
<212>  DNA
<213>  ˹

<400>  101
gcgcccacat aggatgaca                                                  19


<210>  102
<211>  22
<212>  DNA
<213>  ˹

<400>  102
aaggtgccaa cctcaattca tc                                              22


<210>  103
<211>  21
<212>  DNA
<213>  ˹

<400>  103
cacattgtcg gctaaacctg c                                               21


<210>  104
<211>  21
<212>  DNA
<213>  ˹

<400>  104
caagagtgag atcgcccatc g                                               21


<210>  105
<211>  23
<212>  DNA
<213>  ˹

<400>  105
ttacttcctg cactaatttg gca                                             23


<210>  106
<211>  21
<212>  DNA
<213>  ˹

<400>  106
cgactcgcta tctccaagtg a                                               21


<210>  107
<211>  20
<212>  DNA
<213>  ˹

<400>  107
gggcgttgtc caaacagaat                                                 20


<210>  108
<211>  22
<212>  DNA
<213>  ˹

<400>  108
gtgcatacct agccaaatca ct                                              22


<210>  109
<211>  19
<212>  DNA
<213>  ˹

<400>  109
ccaggcccat aaccacaca                                                  19


<210>  110
<211>  22
<212>  DNA
<213>  ˹

<400>  110
gtgacgttga catccgtaaa ga                                              22


<210>  111
<211>  19
<212>  DNA
<213>  ˹

<400>  111
gccggactca tcgtactcc                                                  19


