                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Weiner, David
       Muthumani, Kar
 
<120>  DNA Antibody Constructs for Use Against Zika Virus

<130>  206194-0008-10WO

<150>  US 62/684,349
<151>  2018-06-13

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VH Amino Acid Sequence

<400>  1

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala 
    130             


<210>  2
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VH Nucleic Acid Sequence

<400>  2
atgaacttcg ggctcagctt gattttcctt gccctcattt taaaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggagactta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtaga tatggcatgt cttggggtcg ccagactcca      180

gacaagaggc tggagtgggt cgcaaccatt agtagtggtg gtacttacac ctactatcca      240

gacagtgtga aggggcgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaagtc tgaggacaca gccatgtatt actgtgcccg ttcctggttt      360

gcttactggg gccgagggac tctggtcact gtctctgca                             399


<210>  3
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VL Amino Acid Sequence

<400>  3

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  4
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VL Nucleic Acid Sequence

<400>  4
atgatgagtc ctgcccagtt cctgtttctg ttagtgctct ggattcggga aaccaacggt       60

gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      120

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      180

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtttc taaactggac      240

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      300

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct      360

cacacgttcg gaggggggac caagctggaa ataaaa                                396


<210>  5
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VH Amino Acid Sequence

<400>  5

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  6
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VH Nucleic Acid Sequence

<400>  6
atgaacttcg ggctcagctt gattttcctt gtccttattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagtctcca      180

gagaagaggc tggagtgggt cgcagaaatt agtagtggtg gtagttacac ctactatcca      240

gacactgtga cgggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

gaaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgcaag tgatggttac      360

tactcccact ggggtcaagg aacctcagtc accgtctcct ca                         402


<210>  7
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VL Amino Acid Sequence

<400>  7

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Cys Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  8
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VL Nucleic Acid Sequence

<400>  8
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtctgtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgttttc aaagtacaca tgttcctccg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  9
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VH Amino Acid Sequence

<400>  9

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  10
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VH Nucleic Acid Sequence

<400>  10
atgaacttcg gactcagctt gattttcctt gtccttattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagtctcca      180

gagaagaggc tggagtgggt cgcagaaatt agtagtggtg gtagttacac ctactatcca      240

gacactgtga cgggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

gaaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgcaag tgatggttac      360

tactcccact ggggtcaagg aacctcagtc accgtctcct ca                         402


<210>  11
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VL Amino Acid Sequence

<400>  11

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Arg Ser Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  12
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VL Nucleic Acid Sequence

<400>  12
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc caggagtgat       60

gttgtgatga cccaaattcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctttc aaagtacaca tgttcctccg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  13
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VH Amino Acid Sequence

<400>  13

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  14
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VH Nucleic Acid Sequence

<400>  14
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatgct      240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg      300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgcaag agaaatttcc      360

aaaatttatt actacggtag tagctacgaa aatggtatgg actactgggg tcaaggaacc      420

tcagtcaccg tctcctca                                                    438


<210>  15
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VL Amino Acid Sequence

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Phe Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  16
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VL Nucleic Acid Sequence

<400>  16
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt       60

aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atatcctgca gagccagtga aagtgttgat agttttggca atagttttat gcactggttc      180

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      240

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      300

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga atatccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210>  17
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VH Amino Acid Sequence

<400>  17

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Lys Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  18
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VH Nucleic Acid Sequence

<400>  18
atgaacttcg ggctcagctt gattttcctt gtccttattt taaaaggtgt caagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagtctcca      180

gagaagaggc tggagtgggt cgcagaaatt agtagtggtg gtagttatat ctactatcca      240

gacactgtga cgggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

gaaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgcaag tgatggttac      360

tactcccact ggggtcaagg aacctcagtc accgtctcct ca                         402


<210>  19
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VL Amino Acid Sequence

<400>  19

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  20
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VL Nucleic Acid Sequence

<400>  20
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaagtcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt tcattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggactttat ttctgctctc aaagtacaca tgttcctccg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP306 VH Amino Acid Sequence

<400>  21

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Gly Val Ser Gly Gly Ser Ile Arg Ser Gly 
            20                  25                  30          


Tyr Gly Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Gly Gly Thr Asn Ser Asn Thr Asn Gln Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Gly Gly Gln Met Glu Pro Phe Phe Glu Ile Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP306 VH Nucleic Acid Sequence

<400>  22
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcggtg tctctggtgg ctccatccgc agcggttatg gctggacctg gattcgccag      120

cccccaggga agggcctaga gtggattgga tatatcgggg gaactaatag taatacgaat      180

cagaacccct ctctcaagag tcgggtcacc atttcaaagg acacgtccaa gaatcagttc      240

tccctgaggt taagttctat gaccgccgcg gacacggccg tatattactg tgcgactggc      300

gggcaaatgg agcccttctt tgaaatctgg ggccagggaa tcctggtcac cgtctcctca      360


<210>  23
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP306 VL Amino Acid Sequence

<400>  23

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Glu Ile Leu Thr Lys Lys Tyr Gly 
            20                  25                  30          


Gln Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Ala Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ser Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Thr Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Thr Ser Glu Asn His 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  24
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP306 VL Nucleic Acid Sequence

<400>  24
tcctatgagc tgacacagcc accctcagtg tcagtgtccc caggacagac ggccaggatc       60

acctgttctg gagaaatact gacaaaaaaa tatggtcagt ggttccagca gaagccaggc      120

caggcccctg tgctggtaat atataaagac agtgcgaggc cctcagggat ccctgagcga      180

ttctctagct ccagttcagg gacaacagtt accttgacca tcagtggggc ccagacagaa      240

gatgaggctg actattactg tcaatcagca gacaccagtg aaaatcatcc ggtattcggc      300

ggagggaccc ggctgaccgt ccta                                             324


<210>  25
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP408 VH Amino Acid Sequence

<400>  25

Gln Leu Gln Leu Gln Glu Ser Gly Pro Ala Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Ala Val Ser Asn Gly Ser Ile Ser Thr Thr 
            20                  25                  30          


Asn Trp Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Tyr Gly Ser Gly Gly Tyr Thr Glu Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Met Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Leu Gly Tyr Trp Gly Gln Gly Ala Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  26
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP408 VH Nucleic Acid Sequence

<400>  26
cagctgcagc tgcaggagtc gggtccagca gtggtgaagc cttcggagac cctgtccctc       60

agctgcgctg tctctaatgg ctccatcagt actactaact ggtggaactg gatccgccag      120

tccccaggga agggactgga atggatgggg ggtatctatg gtagtggtgg atacaccgaa      180

tacaacccct ccctcaagag tcgagtcacc atttcaaagg acacgtccaa gaaccaattc      240

tccctgagga tgacctctgt gaccgccgcg gacaccgccg tctactactg tgcgagaggc      300

ttaggctact ggggccaggg agccctggtc accgtctcct ca                         342


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP408 VL Amino Acid Sequence

<400>  27

Gln Pro Met Leu Thr Gln Pro Ala Ser Val Ser Ala Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ile Ser Asn Ile Gly Ala Ser 
            20                  25                  30          


Tyr Val Ser Trp Tyr Arg Gln Val Pro Gly Thr Ala Pro Lys Ile Leu 
        35                  40                  45              


Ile Tyr Gln Asn Asp Lys Arg Lys Val Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ala Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Phe Ser Leu 
                85                  90                  95      


Asn Gly His Leu Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP408 VL Nucleic Acid Sequence

<400>  28
cagcctatgc tgactcagcc ggcctcagtg tctgcgaccc caggacagag ggtcaccatc       60

tcctgctctg gaggcatctc gaacatcggg gcaagttatg tttcgtggta ccggcaggtc      120

ccaggaacag cccccaaaat cctcatatat cagaatgata aacgaaaagt cggggtctct      180

gaccgattct ctggctccaa ggctggaacc tcagcctccc tgaccatcac tggactccag      240

actggagatg aggcggatta ttactgctca gcatgggatt tcagcctgaa cggtcattta      300

ttcggaggag gcaccgagct gaccgtcctc                                       330


<210>  29
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP305 VH Amino Acid Sequence

<400>  29

Gln Leu Gln Leu Gln Glu Ser Gly Pro Ala Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Asn Cys Asp Val Ser Asn Gly Ser Ile Ser Ala Thr 
            20                  25                  30          


Asn Trp Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Tyr Gly Ser Gly Gly Tyr Thr Glu Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Met Thr Ser Val Thr Ala Ala Asp Ala Gly Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Leu Gly Tyr Trp Gly Gln Gly Ala Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  30
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP305 VH Nucleic Acid Sequence

<400>  30
cagctgcagc tgcaggagtc gggtccagca gtggtgaagc cttcggagac cctgtccctc       60

aactgcgatg tctctaatgg ctccatcagt gctactaact ggtggaactg gatccgccag      120

tccccaggga agggactgga atggatgggg ggtatctatg gtagtggagg atacaccgaa      180

tacaacccct ccctgaagag tcgagtcacc atttcaaagg acacgtcgaa gaaccaattc      240

tccctgagga tgacctctgt gaccgccgcg gacgctggcg tctattattg tgcgagagga      300

ttaggctact ggggccaggg agccctggtc accgtctcct ca                         342


<210>  31
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP305 VL Amino Acid Sequence

<400>  31

Gln Ser Val Leu Thr Gln Leu Pro Ser Val Ser Gly Asp Pro Gly Gln 
1               5                   10                  15      


Arg Ile Thr Ile Ser Cys Thr Gly Ser Thr Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Phe Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Leu Tyr Gln Asn Ile Arg Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Ser Leu 
                85                  90                  95      


Ser Ala Trp Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  32
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP305 VL Nucleic Acid Sequence

<400>  32
cagtctgtac tgactcagct gccctcagtg tctggggacc ccggtcagag gatcaccatc       60

tcgtgcactg ggagcacctc caatattgga agttattatg tgtattggtt ccagcagttc      120

ccaggagcag cccccaaact cctcctgtat caaaatatta gacgcccctc aggggtttct      180

gaccgattct ctggctccaa gtctggtacc tcagcctccc tgaccatcac tgggctgcgg      240

cctggggatg aggctgatta ttattgcgga acgtgggatg gcagtctgag tgcttggctg      300

ttcggcggag gcacccagct gaccgtcctc                                       330


<210>  33
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP311 VH Amino Acid Sequence

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Val Val Ser Asn Gly Ser Ile Ser Ser Thr 
            20                  25                  30          


Asn Trp Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Tyr Gly Ser Gly Gly Tyr Thr Glu Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Met Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Leu Gly Tyr Trp Gly Gln Gly Ala Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  34
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP311 VH Nucleic Acid Sequence

<400>  34
caggtgcagc tgcaggagtc aggcccagca gtggtgaagc cttcggagac cctgtccctc       60

agctgcgttg tctctaatgg ctccatcagt agtactaact ggtggaactg gatccgccag      120

tccccaggga agggactgga atggatgggg ggtatctatg gaagtggtgg gtacaccgaa      180

tacaacccct ccctcaagag tcgagtcacc atttcaaagg acacgtccaa gaaccaattc      240

tccctgaaga tgacctctgt gaccgccgcg gacaccgccg tctattattg tgcgagaggg      300

ttaggctact ggggccaggg agccctggtc accgtctcat ca                         342


<210>  35
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP311 VL Amino Acid Sequence

<400>  35

Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Asp Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Leu Cys Thr Gly Ser Arg Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Trp Glu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210>  36
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP311 VL Nucleic Acid Sequence

<400>  36
cagcctgtgc tgactcagcc ggcctcagtg tctggggacc ccgggcagag ggtcaccatc       60

ttgtgcactg ggagccgctc caacattgga agttattatg tatactggta ccaacagttc      120

ccaggaacag cccccaaact cctcatctat gacaataata agcgaccctc agggatttct      180

gaccgattct ctggctccaa gtctggtacg tcagcctccc tgaccatcac tgggctccag      240

cctggggatg aggctgatta ttactgcgga gcatgggata gcagcctgag tgcttgggaa      300

ttcggcggag ggacccggct gaccgtccta                                       330


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP401 VH Amino Acid Sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Gly Asp Tyr 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Asn Ala Gly Gly Arg Ser Trp Leu Ala Glu Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp His Cys Thr Gly Ser Gly Cys Tyr Gly Leu Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Val Val Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP401 VH Nucleic Acid Sequence

<400>  38
gaggtgcagt tggtggagtc tgggggcggc ctggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctctgggtt taggttcggt gactacttca tgcactgggt ccgccaggct      120

tcagggaagg ggctggagtg ggtctcacgt attagtaatg ctggtggtag gtcctggttg      180

gcagagtccg tgaaggacag attcaccatc tccagagaca acaccaagaa tacactttat      240

cttcaaatga ccagcctgag acctgaggac acggctgtct attactgtgc gaaagaccac      300

tgtactggta gtggttgcta cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc      360

tcctca                                                                 366


<210>  39
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP401 VL Amino Acid Sequence

<400>  39

Gln Ser Ala Pro Thr Gln Pro Pro Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Gly Val Ser Trp Tyr Gln Gln His Ser Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Thr Gly Leu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210>  40
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP401 VL Nucleic Acid Sequence

<400>  40
cagtctgccc cgactcagcc tccctcagtg tccaagtctc ttggacagtc ggtcaccatc       60

tcctgttctg gaaccagcag tgacattggc ggttataatg gcgtctcctg gtaccaacaa      120

cactctggga cagcccccag actcctgatt tatgatgtca gtaagcggcc ctcaggggtc      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa cactggctta      300

ttcggaggag ggacccggct gaccgtccta                                       330


<210>  41
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP312 VH Amino Acid Sequence

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Gly Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Gly Gly Ser Ser Gly Thr Thr Asn Tyr Asn Pro Tyr 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Cys Thr Tyr Cys Ser Pro Tyr Tyr Phe Glu Pro Trp 
            100                 105                 110         


Gly Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP312 VH Nucleic Acid Sequence

<400>  42
caggtgcagc tgcaggagtc aggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tctctggtga ctccatcagc aattattatg gctggagttg gatccgccag      120

tccccaggga aggggctgga gtggatgggg tatatcggtg gtagtagtgg taccaccaac      180

tacaacccct acctcaagag tcgagtcacc atttcaaagg acacgtccaa gaaccaattc      240

ttcctgaacc tgaggtctgt gaccgccgca gacacggccg tgtattactg cgcgagattc      300

tgtacgtact gttccccata ctactttgaa ccctggggcc agggagtcct ggtcaccgtc      360

tcctca                                                                 366


<210>  43
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP312 VL Amino Acid Sequence

<400>  43

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Thr Phe Val Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  44
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP312 VL Nucleic Acid Sequence

<400>  44
cagcctgtgc tgacccagcc tccctctgtg tctgggtctc ctggacagtc ggtcaccatc       60

tcctgcactg gaaccagcag tgacatcggt acttataact atgtctcctg gtaccaacag      120

catccaggca aagcccccaa actcatgatt tatgatgtca ataagcggcc ctcaggggtc      180

tctgatcgct tctctggctc caaatctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa cacttttgtg      300

ttcggaagtg gcaccaagtt gaccgtcctc                                       330


<210>  45
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-KP401 VH Amino Acid Sequence

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Leu Ile Gly Ser 
            20                  25                  30          


Phe Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Val Gly Gly Lys Thr Gly Thr Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Ser Ala Asn Thr Ser Thr Asn Glu Leu Ser 
65                  70                  75                  80  


Leu Ser Leu Arg Ser Val Thr Val Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Arg Trp Gly Glu Trp Gly Gln Gly Ile Leu Ala Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  46
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-KP401 VH Nucleic Acid Sequence

<400>  46
caggtgcagc tgcaggagtc aggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tgtctggcga ctccctcatc ggttccttct ggacctggat tcgccaatcc      120

cccgggaagg gactggagtg gattggaaat gtcggtggaa aaacagggac cacctactat      180

aatccctccc tcaaggatcg agtcaccatt tcagccaaca cgtccaccaa tgagttgtcc      240

ctgagcctga ggtccgtgac cgtcgcggac acagccgtct attactgttt gaggaggtgg      300

ggcgaatggg gccagggcat cctggccacc gtctcgtcag                            340


<210>  47
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-KP401 VL Amino Acid Sequence

<400>  47

Glu Leu Val Met Thr Gln Ser Pro Leu Ser Leu Pro Ile Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Met Thr Cys Arg Ser Ser Gln Ser Leu Leu His Ala 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 110         


<210>  48
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-KP401 VL Nucleic Acid Sequence

<400>  48
gagctcgtga tgactcagtc tccactctcc ctgcccatca cccctggaca gccagcctcc       60

atgacctgcc gatctagtca gagcctcctg catgctaatg gaaacactta cttgaattgg      120

tttctgcaga agccaggcca acctccaagg cgcctaattt ataagatttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt ggggcaggga cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgtcggggtt tattactgca tgcaaggcac acactttccg      300

tggacgttcg gccaggggac caaactggat atcaaag                               337


<210>  49
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-KP412 VH Amino Acid Sequence

<400>  49

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Gly Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Tyr Gly Ala Ile Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Pro Val Tyr Cys Ser Gly Ser Asn Cys Pro Ala Trp 
            100                 105                 110         


Asp Tyr Phe Gly Leu Asp Phe Trp Gly Gln Gly Val Val Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  50
<211>  391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-KP412 VH Nucleic Acid Sequence

<400>  50
caggtgcagc tgcaggagtc gggcccagga gtggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccatcagc agtggttatg gctggagctg gatccgccag      120

cccccaggga aggggctgga gtggattggc catatctatg gtgctattgg gaccacctac      180

tacaatccct ccctcaagag tcgagtcacc atttcaaagg acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgcg gacacggccg tgtattactg tgcgagacat      300

cctgtctact gtagtggtag taattgcccc gcctgggatt acttcggttt ggatttttgg      360

ggccaagggg tcgtcgtcac cgtctcctca g                                     391


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-KP412 VL Amino Acid Sequence

<400>  51

Glu Leu Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Ser Arg Gly Ile Gly His Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Gln Asp Glu Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Asn 
            100                 105         


<210>  52
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-KP412 VL Nucleic Acid Sequence

<400>  52
gagctcgtgt tgacgcagtc tccatcttcc ctgtccgcat ctgtaggaga cacagtcacc       60

atcacttgcc aggcgagtcg aggcattggc cataatttaa attggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctatagg gcatccactt tgcaagatga gattccctct      180

cgcttcagtg gcagtggatc tgggacggat ttcagtctca ccatcagcag cctgcagcct      240

gaagattttg ccacttatta ttgtcaacag ggttataatt ttccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa tg                                               322


<210>  53
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP402 VH Amino Acid Sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Ser Asp Phe 
            20                  25                  30          


Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser Gly His Ser Asp Thr Thr His Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Leu Ile Thr Lys Asp Ala Ser Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Thr Leu Phe Ser Val Thr Gly Ala Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ala Lys Leu Pro Ile Ala Arg Val Arg Thr Val Thr Asp Phe Trp Gly 
            100                 105                 110         


Pro Gly Ile Leu Val Ile Val Ser Ser 
        115                 120     


<210>  54
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP402 VH Nucleic Acid Sequence

<400>  54
gaggtgcagc tggtggagtc tggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tttctggtgc ctccgtcagt gatttctggt ggtcctgggt ccgccagtcg      120

ccagggaagg gactggaatg gattggggag atcagtggtc atagtgatac cacccactac      180

aatccctccc tcaagagtcg cgtcctcatc actaaagacg cgtccaagaa tgaggtctac      240

ctcaccttgt tctctgtgac cggcgcggac acggccatgt tttattgtgc aaaactcccc      300

attgcgaggg tgagaacggt gactgacttt tggggcccgg ggatcctagt catcgtctcc      360

tcag                                                                   364


<210>  55
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP402 VL Amino Acid Sequence

<400>  55

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Val Met Ile Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Val Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210>  56
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP402 VL Nucleic Acid Sequence

<400>  56
tcctatgagc tgacacagcc accctcggta tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaaa tatgcttatt ggttccagca gaagccaggc      120

cagtcccctg tgatgatcat ctatgaggac agcaaacggc cctctgggat ccctgagaga      180

ttctctggct ccagctcagg gacagtggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttactcaaca gatagtagtg gtaatcatag ggtattcggc      300

ggagggaccc agctgaccgt cctcg                                            325


<210>  57
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP314 VH Amino Acid Sequence

<400>  57

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Asn Cys Asp Val Ser Asn Gly Ser Ile Ser Ala Thr 
            20                  25                  30          


Asn Trp Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Tyr Gly Ser Gly Gly Tyr Thr Glu Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Met Thr Ser Val Thr Ala Ala Asp Ala Gly Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Leu Gly Tyr Trp Gly Gln Gly Ala Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  58
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP314 VH Nucleic Acid Sequence

<400>  58
caggtgcagc tgcaggagtc aggtccagca gtggtgaagc cttcggagac cctgtccctc       60

aactgcgatg tctctaatgg ctccatcagt gctactaact ggtggaactg gatccgccag      120

tccccaggga agggactgga atggatgggg ggtatctatg gtagtggagg atacaccgaa      180

tacaacccct ccctgaagag tcgagtcacc atttcaaagg acacgtcgaa gaaccaattc      240

tccctgagga tgacctctgt gaccgccgcg gacgctggcg tctattattg tgcgagagga      300

ttaggctact ggggccaggg agccctggtc accgtctcct cag                        343


<210>  59
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP314 VL Amino Acid Sequence

<400>  59

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Asp Pro Gly Gln 
1               5                   10                  15      


Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Phe Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Leu Tyr Gln Asn Ile Arg Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Ser Leu 
                85                  90                  95      


Ser Ala Trp Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  60
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP314 VL Nucleic Acid Sequence

<400>  60
cagtctgtgc tgactcagcc accctcagtg tctggggacc ccggtcagag gatcaccatc       60

tcgtgcactg ggagcagctc caatattgga agttattatg tgtattggtt ccagcagttc      120

ccaggagcag cccccaaact cctcctatat caaaatatta gacgaccctc aggggtttct      180

gaccgattct ctggctccaa gtctggtacc tcagcctccc tgaccatcac tgggctgcgg      240

cctggggatg aggctgatta ttattgcgga acgtgggatg gcagtctgag tgcttggctg      300

ttcggcggag gcacccagct gaccgtcctc                                       330


<210>  61
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP320 VH Amino Acid Sequence

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Asp Val Ser Asn Gly Ser Ile Ser Thr Thr 
            20                  25                  30          


Asn Trp Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Tyr Gly Ser Gly Gly Tyr Thr Glu Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Met Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Leu Gly Tyr Trp Gly Gln Gly Ala Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  62
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP320 VH Nucleic Acid Sequence

<400>  62
caggtgcagc tgcaggagtc gggtccagca gtggtgaagc cttcggagac cctctccctc       60

agctgcgatg tctctaatgg ctccatcagt accactaact ggtggaactg gatccgccag      120

tccccaggga agggactgga atggatgggg ggtatctatg gtagtggtgg atacaccgaa      180

tacaacccct ccctcaagag tcgagtcacc atttcaaagg acacgtccaa gaaccaattc      240

tccctgagga tgacctccgt gaccgccgcg gacaccgccg tctactactg tgcgagaggg      300

ttaggctact ggggccaggg agccctggtc accgtctcct ca                         342


<210>  63
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-LP320 VL Amino Acid Sequence

<400>  63

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Asp Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Trp Glu Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210>  64
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZV-LP320 VL Nucleic Acid Sequence

<400>  64
cagtctgtgc tgacgcagcc gccctcagtg tctggggacc ccgggcagag ggtcaccatc       60

tcgtgcactg ggagccgctc caacattgga agttattatg tatactggta ccaacagttc      120

ccaggaacag cccccaaact cctcatctat gacaataata agcgaccctc agggatttct      180

gaccgattct ctggctccaa gtctggtacg tcagcctccc tgaccatcac tgggctccag      240

cctggggatg aggctgatta ttactgcgga gcatgggata gcagcctgag tgcttgggaa      300

ttcggcggag ggacccggct gaccgtccta                                       330


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VH CDR1 Amino Acid Sequence

<400>  65

Arg Tyr Gly Met Ser 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VH CDR2 Amino Acid Sequence

<400>  66

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VH CDR3 Amino Acid Sequence

<400>  67

Ser Trp Phe Ala Tyr 
1               5   


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VL CDR1 Amino Acid Sequence

<400>  68

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VL CDR2 Amino Acid Sequence

<400>  69

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-3F12E9 VL CDR3 Amino Acid Sequence

<400>  70

Trp Gln Gly Thr His Phe Pro His Thr 
1               5                   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VH CDR1 Amino Acid Sequence

<400>  71

Ser Tyr Ala Met Ser 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VH CDR2 Amino Acid Sequence

<400>  72

Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VH CDR3 Amino Acid Sequence

<400>  73

Asp Gly Tyr Tyr Ser His 
1               5       


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VL CDR1 Amino Acid Sequence

<400>  74

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VL CDR2 Amino Acid Sequence

<400>  75

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1C2A6 VL CDR3 Amino Acid Sequence

<400>  76

Phe Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VH CDR1 Amino Acid Sequence

<400>  77

Ser Tyr Ala Met Ser 
1               5   


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VH CDR2 Amino Acid Sequence

<400>  78

Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VH CDR3 Amino Acid Sequence

<400>  79

Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp 
1               5                   10                  15      


Thr Ala Met Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His 
            20                  25                  30  


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VL CDR1 Amino Acid Sequence

<400>  80

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VL CDR2 Amino Acid Sequence

<400>  81

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8A9F9 VL CDR3 Amino Acid Sequence

<400>  82

Phe Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VH CDR1 Amino Acid Sequence

<400>  83

Asn Tyr Gly Met Asn 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VH CDR2 Amino Acid Sequence

<400>  84

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VH CDR3 Amino Acid Sequence

<400>  85

Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
1               5                   10      


<210>  86
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VL CDR1 Amino Acid Sequence

<400>  86

Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met 
1               5                   10                  


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VL CDR2 Amino Acid Sequence

<400>  87

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-1D4G7 VL CDR3 Amino Acid Sequence

<400>  88

Gln Gln Asn Asn Glu Tyr Pro Tyr Thr 
1               5                   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VH CDR1 Amino Acid Sequence

<400>  89

Ser Tyr Ala Met Ser 
1               5   


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VH CDR2 Amino Acid Sequence

<400>  90

Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VH CDR3 Amino Acid Sequence

<400>  91

Asp Gly Tyr Tyr Ser His 
1               5       


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VL CDR1 Amino Acid Sequence

<400>  92

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Phe His 
1               5                   10                  15      


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VL CDR2 Amino Acid Sequence

<400>  93

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZV-8D10F4 VL CDR3 Amino Acid Sequence

<400>  94

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  95
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D4G7-IgG1 Amino Acid Sequence

<400>  95

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys 
465                 470                 475                 480 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
            500                 505                 510         


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asn Ile Val 
        515                 520                 525             


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
    530                 535                 540                 


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser 
545                 550                 555                 560 


Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                565                 570                 575     


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
            580                 585                 590         


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu 
        595                 600                 605             


Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Tyr Pro 
    610                 615                 620                 


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
625                 630                 635                 640 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                645                 650                 655     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            660                 665                 670         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        675                 680                 685             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    690                 695                 700                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
705                 710                 715                 720 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                725                 730                 735     


Ser Phe Asn Arg Gly Glu Cys 
            740             


<210>  96
<211>  2229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1D4G7-IgG1 Nucleic Acid Sequence

<400>  96
atggactgga catggagaat cctgttcctg gtggcagcag caaccggaac acacgcacag       60

atccagctgg tgcagtccgg acccgagctg aagaagcctg gcgagacagt gaagatcagc      120

tgcaaggcct ccggctatac cttcacaaac tacggcatga attgggtgaa gcaggcccct      180

ggcaagggcc tgaagtggat gggctggatc aacacctata caggcgagcc aacctacgcc      240

gacgacttca agggcaggtt cgcctttagc ctggagacaa gcgccagcac agcctatctg      300

cagatcaaca atctgaagaa cgaggacacc gccacatact tctgcgccag agagatctcc      360

aagatctact attacggcag ctcctatgag aatggcatgg attactgggg ccagggcacc      420

agcgtgacag tgtctagcgc ctctacaaag ggaccaagcg tgtttccact ggcaccctcc      480

tctaagtcca cctctggcgg cacagccgcc ctgggctgtc tggtgaagga ctactttccc      540

gagcctgtga ccgtgagctg gaactccggc gccctgacct ccggagtgca cacattccca      600

gccgtgctgc agagctccgg cctgtatagc ctgtctagcg tggtgaccgt gccttcctct      660

agcctgggca cccagacata catctgcaac gtgaatcaca agcctagcaa tacaaaggtg      720

gacaagaagg tggagccaaa gtcctgtgat aagacccaca catgccctcc ctgtccagca      780

ccagagctgc tgggcggccc aagcgtgttc ctgtttccac ccaagcccaa ggacaccctg      840

atgatctcta ggaccccaga ggtgacatgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcct      960

agggaggagc agtataactc cacctacaga gtggtgtctg tgctgacagt gctgcaccag     1020

gattggctga acggcaagga gtacaagtgc aaggtgtcca ataaggccct gcctgcccca     1080

atcgagaaga ccatctctaa ggcaaaggga cagcctcggg agccacaggt gtatacactg     1140

cctccatccc gcgacgagct gaccaagaac caggtgtctc tgacatgtct ggtgaagggc     1200

ttttacccca gcgatatcgc cgtggagtgg gagtccaatg gccagcctga gaacaattat     1260

aagaccacac cccctgtgct ggactctgat ggcagcttct ttctgtactc taagctgacc     1320

gtggacaaga gcagatggca gcagggcaac gtgttcagct gctccgtgat gcacgaggcc     1380

ctgcacaatc actacaccca gaagtctctg agcctgtccc caggcaagag gggaaggaag     1440

aggagatctg gcagcggcgc cacaaacttt agcctgctga agcaggcagg cgatgtggag     1500

gagaatccag gacctatggt gctgcagacc caggtgttca tcagcctgct gctgtggatc     1560

tccggcgcct atggcaatat cgtgctgacc cagtccccag catctctggc cgtgtctctg     1620

ggacagaggg ccacaatcag ctgtagagcc tccgagtctg tggactcttt cggcaacagc     1680

tttatgcact ggttccagca gaagcctggc cagccaccca agctgctgat ctacctggcc     1740

tccaatctgg agtctggagt gccagcacgg tttagcggct ccggctctcg caccgacttc     1800

accctgacaa tcgatccagt ggaggcagac gatgcagcaa catattactg ccagcagaac     1860

aatgagtatc cttacacctt cggcggcggc acaaagctgg agatcaagag gaccgtggca     1920

gcaccatccg tgttcatctt tcctccatct gacgagcagc tgaagagcgg cacagcctcc     1980

gtggtgtgcc tgctgaacaa tttctatcca cgcgaggcca aggtgcagtg gaaggtggat     2040

aacgccctgc agagcggcaa ttcccaggag tctgtgaccg agcaggacag caaggattcc     2100

acatactctc tgtcctctac cctgacactg tccaaggccg attatgagaa gcacaaggtg     2160

tacgcatgcg aggtgaccca ccagggcctg agctccccag tgacaaagag cttcaaccgc     2220

ggcgagtgt                                                             2229


<210>  97
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D4G7-IgG4 Amino Acid Sequence

<400>  97

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
                245                 250                 255     


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asn Ile Val Leu Thr Gln 
        515                 520                 525             


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
    530                 535                 540                 


Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
545                 550                 555                 560 


Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu 
                565                 570                 575     


Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
            580                 585                 590         


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
625                 630                 635                 640 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                645                 650                 655     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            660                 665                 670         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        675                 680                 685             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    690                 695                 700                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
705                 710                 715                 720 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                725                 730                 735     


Arg Gly Glu Cys 
            740 


<210>  98
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1D4G7-IgG4 Nucleic Acid Sequence

<400>  98
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcacag       60

atccagctgg tgcagtccgg accagagctg aagaagcccg gcgagacagt gaagatctct      120

tgcaaggcca gcggctatac cttcacaaac tacggcatga attgggtgaa gcaggcccct      180

ggcaagggcc tgaagtggat gggctggatc aacacctata caggcgagcc aacctacgcc      240

gacgacttca agggcaggtt cgcctttagc ctggagacat ctgccagcac cgcctatctg      300

cagatcaaca atctgaagaa cgaggacacc gccacatact tctgtgccag agagatctcc      360

aagatctact attacggcag ctcctatgag aatggcatgg attactgggg ccagggcaca      420

agcgtgaccg tgtctagcgc ctccaccaag ggacctagcg tgttcccact ggcaccatgc      480

tcccgctcta caagcgagtc caccgccgcc ctgggatgtc tggtgaagga ctactttcct      540

gagccagtga ccgtgtcttg gaacagcggc gccctgacat ctggcgtgca caccttccca      600

gccgtgctgc agtcctctgg cctgtatagc ctgagctccg tggtgacagt gccctctagc      660

tccctgggca ccaagacata cacctgcaac gtggaccaca agcctagcaa taccaaggtg      720

gataagaggg tgtcccccaa tatggtgcct cacgcacacc acgcacaggc acctgagttc      780

ctgggcggcc catccgtgtt cctgtttccc cctaagccca aggacaccct gatgatctcc      840

agaacacctg aggtgacctg cgtggtggtg gacgtgtctc aggaggaccc cgaggtgcag      900

tttaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc tcgggaggag      960

cagttcaaca gcacatatcg cgtggtgtcc gtgctgaccg tgctgcacca ggattggctg     1020

aacggcaagg agtacaagtg caaggtgagc aataagggcc tgccctctag catcgagaag     1080

acaatctcca aggccaaggg ccagcctagg gagccacagg tgtataccct gccaccctct     1140

caggaggaga tgacaaagaa ccaggtgagc ctgacctgtc tggtgaaggg cttttaccca     1200

tctgacatcg ccgtggagtg ggagagcaat ggccagcccg agaacaatta taagaccaca     1260

cctccagtgc tggactccga tggctctttc tttctgtact cccggctgac cgtggataag     1320

tctcgctggc aggagggcaa cgtgttctct tgcagcgtga tgcacgaggc cctgcacaat     1380

cactacacac agaagtccct gtctctgagc ctgggcaaga ggggaaggaa gaggagatcc     1440

ggctctggcg ccaccaactt tagcctgctg aagcaggcag gcgacgtgga ggagaatcca     1500

ggacctatgg tgctgcagac acaggtgttc atctctctgc tgctgtggat cagcggcgcc     1560

tatggcaata tcgtgctgac acagagccca gcatccctgg ccgtgtccct gggacagagg     1620

gccaccatct cttgtagagc cagcgagtcc gtggattcct tcggcaactc ttttatgcac     1680

tggttccagc agaagccagg acagccccct aagctgctga tctacctggc cagcaatctg     1740

gagtccggcg tgccagccag gttttctggc agcggctcca gaacagactt cacactgacc     1800

atcgatccag tggaggcaga cgatgcagca acctattact gccagcagaa caatgagtat     1860

ccttacacct tcggcggcgg caccaagctg gagatcaagc ggacagtggc cgccccaagc     1920

gtgttcatct ttccaccctc cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc     1980

ctgctgaaca atttctatcc ccgcgaggcc aaggtgcagt ggaaggtgga taacgccctg     2040

cagtctggca atagccagga gtccgtgaca gagcaggact ctaaggatag cacctactcc     2100

ctgtcctcta cactgaccct gtccaaggcc gactatgaga agcacaaggt gtacgcctgc     2160

gaggtgacac accagggcct gagctcccct gtgaccaaga gcttcaacag gggcgagtgt     2220


<210>  99
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F12E9-IgG1 Amino Acid Sequence

<400>  99

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg 
    450                 455                 460                 


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
465                 470                 475                 480 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
                485                 490                 495     


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
            500                 505                 510         


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
        515                 520                 525             


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
    530                 535                 540                 


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
            580                 585                 590         


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
        595                 600                 605             


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  100
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F12E9-IgG1 Nucleic Acid Sequence

<400>  100
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagtccgg cggcgatctg gtgaagcccg gcggctctct gaagctgagc      120

tgcgccgcct ccggcttcac cttttctaga tacggcatga gctggggccg gcagacacca      180

gacaagcgcc tggagtgggt ggcaaccatc agctccggcg gcacctacac atactatccc      240

gacagcgtga agggcaggtt tacaatctcc agagataacg ccaagaatac cctgtatctg      300

cagatgtcta gcctgaagag cgaggatacc gccatgtact attgcgcacg gtcctggttc      360

gcatactggg gaaggggcac cctggtgaca gtgtctgccg ccagcacaaa gggccctagc      420

gtgtttcccc tggccccttc ctctaagtcc acctctggcg gcacagccgc cctgggctgt      480

ctggtgaagg actacttccc tgagccagtg accgtgtcct ggaactctgg cgccctgacc      540

tctggcgtgc acacatttcc tgccgtgctg cagagctccg gcctgtacag cctgtctagc      600

gtggtgacag tgccatcctc tagcctgggc acccagacat atatctgcaa cgtgaatcac      660

aagccttcta ataccaaggt ggacaagaag gtggagccaa agagctgtga taagacccac      720

acatgccctc cctgtccagc acctgagctg ctgggcggcc caagcgtgtt cctgtttcca      780

cccaagccta aggacaccct gatgatctcc cggaccccag aggtgacatg cgtggtggtg      840

gacgtgtctc acgaggaccc cgaggtgaag ttcaactggt acgtggatgg cgtggaggtg      900

cacaatgcca agaccaagcc cagggaggag cagtacaact ccacatatag agtggtgtct      960

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgagc     1020

aataaggccc tgccagcccc catcgagaag acaatctcca aggcaaaggg acagccacgg     1080

gagccacagg tgtataccct gcctccatcc cgcgacgagc tgacaaagaa ccaggtgtct     1140

ctgacctgtc tggtgaaggg cttctacccc tctgatatcg ccgtggagtg ggagagcaat     1200

ggccagcctg agaacaatta caagaccaca ccccctgtgc tggacagcga tggctccttc     1260

tttctgtatt ctaagctgac cgtggataag agccgctggc agcagggcaa cgtgtttagc     1320

tgctccgtga tgcacgaggc cctgcacaat cactatacac agaagtctct gagcctgtcc     1380

ccaggcaaga ggggaaggaa gaggagatct ggcagcggcg ccaccaactt ctccctgctg     1440

aagcaggcag gcgacgtgga ggagaatcct ggaccaatgg tgctgcagac acaggtgttt     1500

atcagcctgc tgctgtggat ctccggagca tacggcgacg tggtcatgac ccagacacca     1560

ctgaccctga gcgtgacaat cggccagccc gcctccatct cttgtaagtc ctctcagtct     1620

ctgctggaca gcgatggcaa gacctacctg aactggctgc tgcagaggcc tggacagtcc     1680

ccaaagagac tgatctatct ggtgtccaag ctggactctg gcgtgcctga taggttcaca     1740

ggcagcggct ccggcaccga ctttacactg aagatcagca gagtggaggc cgaggatctg     1800

ggcgtgtact attgctggca gggaacccac ttcccacaca ccttcggcgg cggcaccaag     1860

ctggagatca agcggacagt ggccgcccct tccgtgttca tctttccacc ctctgacgag     1920

cagctgaaga gcggaaccgc atccgtggtg tgcctgctga acaatttcta tcctcgcgag     1980

gccaaggtgc agtggaaggt ggataacgcc ctgcagtctg gcaatagcca ggagtccgtg     2040

acagagcagg actctaagga tagcacctac tccctgagct ccaccctgac actgtccaag     2100

gccgactacg agaagcacaa ggtgtatgcc tgcgaggtga cacaccaggg cctgtctagc     2160

ccagtgacca agagctttaa taggggcgag tgt                                  2193


<210>  101
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F12E9-IgG4 Amino Acid Sequence

<400>  101

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala His 
225                 230                 235                 240 


His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys 
    450                 455                 460                 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
                485                 490                 495     


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val Val 
            500                 505                 510         


Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala 
        515                 520                 525             


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys 
    530                 535                 540                 


Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg 
545                 550                 555                 560 


Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe 
                565                 570                 575     


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
            580                 585                 590         


Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe 
        595                 600                 605             


Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  102
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F12E9-IgG4 Nucleic Acid Sequence

<400>  102
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcgatctg gtgaagcccg gcggctccct gaagctgtct      120

tgcgccgcca gcggcttcac cttttcccgc tatggcatgt cttggggccg gcagacccca      180

gacaagcgcc tggagtgggt ggccacaatc agctccggcg gcacctacac atactatccc      240

gactctgtga agggcaggtt caccatcagc agagataacg ccaagaatac actgtatctg      300

cagatgtcta gcctgaagtc cgaggataca gccatgtact attgtgccag gtcttggttc      360

gcctactggg gcagaggcac actggtgacc gtgtccgccg catctaccaa gggaccatcc      420

gtgtttccac tggcaccttg ctccaggtct acaagcgagt ccaccgccgc cctgggatgt      480

ctggtgaagg actacttccc agagccagtg accgtgagct ggaactccgg cgccctgaca      540

tccggagtgc acacctttcc tgccgtgctg cagtcctctg gcctgtactc tctgagctcc      600

gtggtgaccg tgccttctag ctccctgggc accaagacat atacctgcaa cgtggaccac      660

aagccaagca atacaaaggt ggataagagg gtgtccccta atatggtgcc acacgcacac      720

cacgcacagg caccagagtt cctgggcggc ccaagcgtgt tcctgtttcc ccctaagcct      780

aaggacacac tgatgatcag cagaacacca gaggtgacct gcgtggtggt ggacgtgtcc      840

caggaggacc ccgaggtgca gttcaactgg tacgtggatg gcgtggaggt gcacaatgcc      900

aagaccaagc cacgggagga gcagtttaac agcacctacc gcgtggtgtc cgtgctgaca      960

gtgctgcacc aggattggct gaacggcaag gagtataagt gcaaggtgtc taataagggc     1020

ctgccttcta gcatcgagaa gaccatcagc aaggccaagg gccagccaag agagccccag     1080

gtgtatacac tgccaccctc tcaggaggag atgaccaaga accaggtgag cctgacatgt     1140

ctggtgaagg gcttctaccc atccgacatc gccgtggagt gggagtctaa tggccagccc     1200

gagaacaatt acaagaccac acctccagtg ctggactctg atggcagctt ctttctgtat     1260

tccaggctga ccgtggataa gtctagatgg caggagggca acgtgttttc ttgcagcgtg     1320

atgcacgagg ccctgcacaa tcactatacc cagaagtccc tgtctctgag cctgggcaag     1380

aggggaagga agaggagatc cggctctggc gccacaaact tctccctgct gaagcaggca     1440

ggcgacgtgg aggagaatcc tggaccaatg gtgctgcaga cccaggtgtt tatctctctg     1500

ctgctgtgga tcagcggcgc ctacggcgac gtggtcatga cacagactcc cctgacgctg     1560

agcgtgacca tcggccagcc tgccagcatc tcctgtaagt cctctcagtc cctgctggat     1620

tccgatggca agacatacct gaactggctg ctgcagcggc ccggacagtc ccctaagcgc     1680

ctgatctatc tggtgagcaa gctggactcc ggcgtgccag ataggttcac cggctctggc     1740

agcggcacag actttaccct gaagatcagc agagtggagg ccgaggatct gggcgtgtac     1800

tattgctggc agggcacaca cttcccccac accttcggcg gcggcacaaa gctggagatc     1860

aagaggaccg tggcagcacc tagcgtgttc atctttcccc cttccgacga gcagctgaag     1920

tctggcacag ccagcgtggt gtgcctgctg aacaatttct atccacgcga ggccaaggtg     1980

cagtggaagg tggataacgc cctgcagtcc ggcaattctc aggagagcgt gaccgagcag     2040

gactccaagg attctacata cagcctgagc tccacactga ccctgtccaa ggccgactac     2100

gagaagcaca aggtgtatgc ctgcgaggtg acccaccagg gcctgtctag ccccgtgaca     2160

aagagcttta atcggggcga gtgt                                            2184


<210>  103
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8A9F9-IgG1 Amino Acid Sequence

<400>  103

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  104
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8A9F9-IgG1 Nucleic Acid Sequence

<400>  104
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgaagcccg gcggctctct gaagctgagc      120

tgcgccgcct ccggcttcac cttcagcagc tacgccatgt cctgggtgcg gcagtctcca      180

gagaagcgcc tggagtgggt ggccgagatc tctagcggcg gctcctacac ctactatccc      240

gacaccgtga caggcaggtt cacaatctct agagataacg ccaagaatac cctgtatctg      300

gagatgtcct ctctgcgcag cgaggacaca gccatgtact attgcgccag cgatggctac      360

tattcccact ggggacaggg cacctccgtg acagtgagct ccgcctctac caagggccct      420

agcgtgtttc cactggcccc ctctagcaag tctaccagcg gcggcacagc cgccctggga      480

tgtctggtga aggattactt ccccgagcct gtgaccgtgt cctggaactc tggcgccctg      540

accagcggag tgcacacatt tcccgccgtg ctgcagtcct ctggcctgta ctccctgagc      600

tccgtggtca cagtgccttc tagctccctg ggcacccaga catatatctg caacgtgaat      660

cacaagccct ccaataccaa ggtggacaag aaggtggagc ctaagtcttg tgataagacc      720

cacacatgcc ctccctgtcc agcaccagag ctgctgggcg gccctagcgt gttcctgttt      780

ccacccaagc caaaggacac actgatgatc agcagaaccc ctgaggtgac atgcgtggtg      840

gtggacgtgt cccacgagga ccccgaggtg aagttcaact ggtacgtgga tggcgtggag      900

gtgcacaatg ccaagaccaa gcctcgggag gagcagtaca actccacata tcgcgtggtg      960

tctgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtataa gtgcaaggtg     1020

tctaataagg ccctgcctgc cccaatcgag aagacaatca gcaaggccaa gggccagcct     1080

agggagccac aggtgtacac cctgcctcca tctagagacg agctgacaaa gaaccaggtg     1140

agcctgacct gtctggtgaa gggcttctat ccaagcgata tcgccgtgga gtgggagtcc     1200

aatggccagc ccgagaacaa ttacaagacc acaccccctg tgctggacag cgatggctcc     1260

ttctttctgt attctaagct gaccgtggac aagagcaggt ggcagcaggg caacgtgttt     1320

tcctgctctg tgatgcacga ggccctgcac aatcactaca cacagaagag cctgtccctg     1380

tctccaggca agaggggaag gaagaggaga agcggctccg gagcaaccaa cttcagcctg     1440

ctgaagcagg caggcgatgt ggaggagaat ccaggaccta tggtgctgca gacacaggtg     1500

tttatcagcc tgctgctgtg gatctccgga gcatacggcg acgtggtcat gacccagatc     1560

cccctgtctc tgcctgtgag cctgggcgat caggcctcta tcagctgtag gtctagccag     1620

tccctggtgc actctaacgg caatacctac ctgcactggt atctgcagaa gccaggccag     1680

tcccccaagc tgctgatcta caaggtgagc aacaggttct ccggcgtgcc cgacagattt     1740

tccggctctg gcagcggcac cgatttcaca ctgaagatca gccgggtgga ggcagaggac     1800

ctgggcgtgt atttctgctt tcagtccacc cacgtgcctc ccaccttcgg cggcggcacc     1860

aagctggaga tcaagcgcac agtggccgcc ccttccgtgt tcatctttcc tccatctgac     1920

gagcagctga agtctggcac cgccagcgtg gtgtgcctgc tgaacaattt ctacccaagg     1980

gaggccaagg tgcagtggaa ggtggataac gccctgcagt ctggcaatag ccaggagtcc     2040

gtgacagagc aggactctaa ggatagcacc tattccctgt cctctaccct gacactgagc     2100

aaggccgatt acgagaagca caaggtgtat gcctgcgagg tgacacacca gggcctgagc     2160

tcccccgtga ccaagtcctt taatagaggc gagtgt                               2196


<210>  105
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8A9F9-IgG4 Amino Acid Sequence

<400>  105

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala 
225                 230                 235                 240 


His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
465                 470                 475                 480 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
                485                 490                 495     


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val 
            500                 505                 510         


Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
        515                 520                 525             


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
    530                 535                 540                 


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
            580                 585                 590         


Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Ser Thr His 
        595                 600                 605             


Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    610                 615                 620                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
625                 630                 635                 640 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                645                 650                 655     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            660                 665                 670         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        675                 680                 685             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    690                 695                 700                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
705                 710                 715                 720 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 


<210>  106
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8A9F9-IgG4 Nucleic Acid Sequence

<400>  106
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgaagcccg gcggctccct gaagctgtct      120

tgcgccgcca gcggcttcac ctttagctcc tacgccatga gctgggtgcg gcagtcccca      180

gagaagcgcc tggagtgggt ggcagagatc tctagcggcg gcagctacac atactatccc      240

gacaccgtga caggcaggtt caccatctcc agagataacg ccaagaatac actgtatctg      300

gagatgtcct ctctgcggag cgaggacacc gccatgtact attgtgcctc tgatggctac      360

tatagccact ggggacaggg cacatccgtg accgtgagct ccgcctccac aaagggacca      420

agcgtgttcc cactggcacc atgctctcgc agcacatccg agtctaccgc cgccctggga      480

tgtctggtga aggactactt ccctgagcca gtgaccgtga gctggaactc cggcgccctg      540

acaagcggag tgcacacctt tccagccgtg ctgcagtcta gcggcctgta ctccctgtcc      600

tctgtggtga ccgtgcccag ctcctctctg ggcaccaaga catatacctg caacgtggac      660

cacaagcctt ccaatacaaa ggtggataag agggtgtctc ccaatatggt gcctcacgcc      720

caccacgcac aggcaccaga gttcctgggc ggccctagcg tgttcctgtt tccccctaag      780

ccaaaggaca ccctgatgat ctctagaaca cccgaggtga cctgcgtggt ggtggacgtg      840

agccaggagg accccgaggt gcagttcaac tggtacgtgg atggcgtgga ggtgcacaat      900

gccaagacca agccaaggga ggagcagttt aacagcacct acagagtggt gtccgtgctg      960

acagtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gtccaataag     1020

ggcctgccta gctccatcga gaagaccatc tctaaggcaa agggacagcc tcgggagcca     1080

caggtgtaca cactgccacc cagccaggag gagatgacca agaaccaggt gtccctgaca     1140

tgtctggtga agggcttcta tccttctgac atcgccgtgg agtgggagag caatggccag     1200

ccagagaaca attacaagac cacacctcca gtgctggact ctgatggcag cttctttctg     1260

tattccaggc tgaccgtgga taagtctaga tggcaggagg gcaacgtgtt tagctgctcc     1320

gtgatgcacg aggccctgca caatcactac acccagaagt ctctgagcct gtccctgggc     1380

aagaggggaa ggaagaggag atctggcagc ggcgccacaa acttcagcct gctgaagcag     1440

gcaggcgatg tggaggagaa tccaggacct atggtgctgc agacccaggt gtttatctct     1500

ctgctgctgt ggatcagcgg cgcctatggc gacgtggtca tgacacagat cccactgtcc     1560

ctgcccgtgt ctctgggcga tcaggcctcc atctcttgtc gctctagcca gagcctggtg     1620

cactccaacg gcaataccta cctgcactgg tatctgcaga agcctggcca gtccccaaag     1680

ctgctgatct acaaggtgtc taaccggttc agcggagtgc ctgaccgctt tagcggctcc     1740

ggctctggca cagatttcac cctgaagatc tctcgggtgg aggcagagga cctgggcgtg     1800

tatttctgct ttcagtccac acacgtgcct cccaccttcg gcggcggcac aaagctggag     1860

atcaagagga ccgtggcagc accaagcgtg ttcatctttc caccctccga cgagcagctg     1920

aagtccggca cagcctctgt ggtgtgcctg ctgaacaatt tctaccctag ggaggccaag     1980

gtgcagtgga aggtggataa cgccctgcag tccggcaatt ctcaggagag cgtgaccgag     2040

caggactcca aggattctac atatagcctg tcctctacac tgaccctgag caaggccgat     2100

tacgagaagc acaaggtgta tgcatgcgag gtgacccacc agggcctgag ctccccagtg     2160

acaaagtcct ttaatagagg cgagtgt                                         2187


<210>  107
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8D10F4-IgG1 Amino Acid Sequence

<400>  107

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  108
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8D10F4-IgG1 Nucleic Acid Sequence

<400>  108
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgaagcccg gcggcagcct gaagctgtcc      120

tgcgccgcct ctggcttcac ctttagctcc tacgccatga gctgggtgcg gcagtcccca      180

gagaagcgcc tggagtgggt ggcagagatc tctagcggcg gcagctacat ctactatccc      240

gacaccgtga caggcaggtt cacaatctcc agagataacg ccaagaatac cctgtatctg      300

gagatgtcct ctctgcgcag cgaggacaca gccatgtact attgcgcctc tgatggctac      360

tatagccact ggggacaggg cacctccgtg acagtgagct ccgcctccac caagggacct      420

agcgtgttcc cactggcacc ctctagcaag tctaccagcg gcggcacagc cgccctggga      480

tgtctggtga aggattactt ccccgagcct gtgaccgtga gctggaactc cggcgccctg      540

acctctggag tgcacacatt tcccgccgtg ctgcagtcct ctggcctgta ctccctgagc      600

tccgtggtca cagtgccttc tagctccctg ggcacccaga catatatctg caacgtgaat      660

cacaagccca gcaataccaa ggtggacaag aaggtggagc ctaagtcctg tgataagacc      720

cacacatgcc ctccctgtcc agcaccagag ctgctgggcg gccctagcgt gttcctgttt      780

ccacccaagc caaaggacac actgatgatc tctagaaccc ctgaggtgac atgcgtggtg      840

gtggacgtga gccacgagga ccccgaggtg aagttcaact ggtacgtgga tggcgtggag      900

gtgcacaatg ccaagaccaa gcctcgggag gagcagtaca acagcacata tcgcgtggtg      960

tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtataa gtgcaaggtg     1020

tccaataagg ccctgcctgc cccaatcgag aagacaatct ctaaggccaa gggccagcct     1080

agggagccac aggtgtacac cctgcctcca tccagagacg agctgacaaa gaaccaggtg     1140

tctctgacct gtctggtgaa gggcttctat ccatctgata tcgccgtgga gtgggagagc     1200

aatggccagc ccgagaacaa ttacaagacc acaccccctg tgctggactc tgatggcagc     1260

ttctttctgt attccaagct gaccgtggac aagtctaggt ggcagcaggg caacgtgttt     1320

tcctgctctg tgatgcacga ggccctgcac aatcactaca cacagaagag cctgtccctg     1380

tctccaggca agaggggaag gaagaggaga agcggctccg gagcaaccaa cttcagcctg     1440

ctgaagcagg caggcgatgt ggaggagaat ccaggaccta tggtgctgca gacacaggtg     1500

tttatctctc tgctgctgtg gatcagcgga gcatacggcg acgtggtcat gacccagagc     1560

cccctgtctc tgcccgtgag cctgggcgat caggcctcta tcagctgtag gtctagccag     1620

agcctggtgc actccaacgg caatacctac ttccactggt atctgcagaa gccaggccag     1680

agccccaagc tgctgatcta caaggtgtct aacaggttca gcggcgtgcc cgacagattt     1740

tccggctctg gcagcggaac cgacttcacc ctgaagatct cccgggtgga ggcagaggac     1800

ctgggcctgt atttctgctc ccagtctacc cacgtgcctc ccaccttcgg cggcggcacc     1860

aagctggaga tcaagcgcac agtggccgcc cctagcgtgt tcatctttcc tccatccgac     1920

gagcagctga agtccggcac cgcctctgtg gtgtgcctgc tgaacaattt ctacccaagg     1980

gaggccaagg tgcagtggaa ggtggataac gccctgcaga gcggcaattc ccaggagtct     2040

gtgacagagc aggacagcaa ggattccacc tattctctgt cctctaccct gacactgagc     2100

aaggccgatt acgagaagca caaggtgtat gcctgcgagg tgacacacca gggcctgagc     2160

tcccccgtga ccaagtcctt taatagaggc gagtgt                               2196


<210>  109
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8D10F4-IgG4 Amino Acid Sequence

<400>  109

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala 
225                 230                 235                 240 


His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
465                 470                 475                 480 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
                485                 490                 495     


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val 
            500                 505                 510         


Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
        515                 520                 525             


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
    530                 535                 540                 


Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
            580                 585                 590         


Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser Thr His 
        595                 600                 605             


Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  110
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8D10F4-IgG4 Nucleic Acid Sequence

<400>  110
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgaagcccg gcggctctct gaagctgagc      120

tgcgccgcct ccggcttcac ctttagctcc tacgccatgt cttgggtgcg gcagagccca      180

gagaagcgcc tggagtgggt ggcagagatc tctagcggcg gctcttacat ctactatccc      240

gacaccgtga caggcaggtt caccatcagc agagataacg ccaagaatac actgtatctg      300

gagatgtcct ctctgaggag cgaggacacc gccatgtact attgtgcctc cgatggctac      360

tattctcact ggggccaggg cacatccgtg accgtgagct ccgccagcac aaagggccca      420

tccgtgtttc cactggcccc ctgctctaga agcacatccg agtctaccgc cgccctggga      480

tgtctggtga aggactactt ccctgagcca gtgaccgtgt cttggaacag cggcgccctg      540

acatccggag tgcacacctt tccagccgtg ctgcagtcta gcggcctgta ctctctgtcc      600

tctgtggtga ccgtgcccag ctcctctctg ggcaccaaga catatacctg caacgtggac      660

cacaagccta gcaatacaaa ggtggataag cgggtgtccc ccaatatggt gcctcacgcc      720

caccacgcac aggcaccaga gttcctgggc ggccctagcg tgttcctgtt tccccctaag      780

ccaaaggaca ccctgatgat ctcccgcaca ccagaggtga cctgcgtggt ggtggacgtg      840

tctcaggagg accccgaggt gcagttcaac tggtacgtgg atggcgtgga ggtgcacaat      900

gccaagacaa agccaaggga ggagcagttt aactctacct acagagtggt gagcgtgctg      960

acagtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gagcaataag     1020

ggcctgccta gctccatcga gaagaccatc tccaaggcaa agggacagcc tcgcgagcca     1080

caggtgtaca cactgccacc ctctcaggag gagatgacca agaaccaggt gagcctgaca     1140

tgtctggtga agggcttcta tccttccgac atcgccgtgg agtgggagtc taatggccag     1200

ccagagaaca attacaagac cacacctcca gtgctggact ccgatggctc tttctttctg     1260

tatagcaggc tgaccgtgga taagtccaga tggcaggagg gcaacgtgtt tagctgctcc     1320

gtgatgcacg aggccctgca caatcactac acccagaagt ctctgagcct gtccctgggc     1380

aagaggggaa ggaagaggag atctggcagc ggcgccacaa acttcagcct gctgaagcag     1440

gcaggcgatg tggaggagaa tccaggacct atggtgctgc agacccaggt gtttatctcc     1500

ctgctgctgt ggatctctgg cgcctatggc gacgtggtca tgacacagag cccactgtcc     1560

ctgcccgtgt ccctgggcga tcaggcctcc atctcttgtc ggtctagcca gtctctggtg     1620

cacagcaacg gcaataccta cttccactgg tatctgcaga agcctggcca gagcccaaag     1680

ctgctgatct acaaggtgtc caaccggttc tctggagtgc ctgaccgctt tagcggctcc     1740

ggctctggca cagacttcac cctgaagatc tcccgcgtgg aggcagagga cctgggcctg     1800

tatttctgca gccagtccac acacgtgcct cccaccttcg gcggcggcac aaagctggag     1860

atcaagaccg tggccgcccc cagcgtgttc atctttccac ccagcgacga gcagctgaag     1920

agcggcacag cctccgtggt gtgcctgctg aacaatttct accctaggga ggccaaggtg     1980

cagtggaagg tggataacgc cctgcagtct ggcaatagcc aggagtccgt gaccgagcag     2040

gactctaagg atagcacata ttccctgtcc tctacactga ccctgagcaa ggccgattac     2100

gagaagcaca aggtgtatgc atgcgaggtg acccaccagg gcctgagctc cccagtgaca     2160

aagtccttta atagaggcga gtgt                                            2184


<210>  111
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F12E9-LALA Amino Acid Sequence

<400>  111

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg 
    450                 455                 460                 


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
465                 470                 475                 480 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
                485                 490                 495     


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
            500                 505                 510         


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
        515                 520                 525             


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
    530                 535                 540                 


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
            580                 585                 590         


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
        595                 600                 605             


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  112
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F12E9-LALA Nucleic Acid Sequence

<400>  112
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagtccgg cggcgatctg gtgaagcccg gcggctctct gaagctgagc      120

tgcgccgcct ccggcttcac cttttctaga tacggcatga gctggggccg gcagacacca      180

gacaagcgcc tggagtgggt ggcaaccatc agctccggcg gcacctacac atactatccc      240

gacagcgtga agggcaggtt tacaatctcc agagataacg ccaagaatac cctgtatctg      300

cagatgtcta gcctgaagag cgaggatacc gccatgtact attgcgcacg gtcctggttc      360

gcatactggg gaaggggcac cctggtgaca gtgtctgccg ccagcacaaa gggccctagc      420

gtgtttcccc tggccccttc ctctaagtcc acctctggcg gcacagccgc cctgggctgt      480

ctggtgaagg actacttccc tgagccagtg accgtgtcct ggaactctgg cgccctgacc      540

tctggcgtgc acacatttcc tgccgtgctg cagagctccg gcctgtacag cctgtctagc      600

gtggtgacag tgccatcctc tagcctgggc acccagacat atatctgcaa cgtgaatcac      660

aagccttcta ataccaaggt ggacaagaag gtggagccaa agagctgtga taagacccac      720

acatgccctc cctgtccagc acctgagctg ctgggcggcc caagcgtgtt cctgtttcca      780

cccaagccta aggacaccct gatgatctcc cggaccccag aggtgacatg cgtggtggtg      840

gacgtgtctc acgaggaccc cgaggtgaag ttcaactggt acgtggatgg cgtggaggtg      900

cacaatgcca agaccaagcc cagggaggag cagtacaact ccacatatag agtggtgtct      960

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgagc     1020

aataaggccc tgccagcccc catcgagaag acaatctcca aggcaaaggg acagccacgg     1080

gagccacagg tgtataccct gcctccatcc cgcgacgagc tgacaaagaa ccaggtgtct     1140

ctgacctgtc tggtgaaggg cttctacccc tctgatatcg ccgtggagtg ggagagcaat     1200

ggccagcctg agaacaatta caagaccaca ccccctgtgc tggacagcga tggctccttc     1260

tttctgtatt ctaagctgac cgtggataag agccgctggc agcagggcaa cgtgtttagc     1320

tgctccgtga tgcacgaggc cctgcacaat cactatacac agaagtctct gagcctgtcc     1380

ccaggcaaga ggggaaggaa gaggagatct ggcagcggcg ccaccaactt ctccctgctg     1440

aagcaggcag gcgacgtgga ggagaatcct ggaccaatgg tgctgcagac acaggtgttt     1500

atcagcctgc tgctgtggat ctccggagca tacggcgacg tggtcatgac ccagacacca     1560

ctgaccctga gcgtgacaat cggccagccc gcctccatct cttgtaagtc ctctcagtct     1620

ctgctggaca gcgatggcaa gacctacctg aactggctgc tgcagaggcc tggacagtcc     1680

ccaaagagac tgatctatct ggtgtccaag ctggactctg gcgtgcctga taggttcaca     1740

ggcagcggct ccggcaccga ctttacactg aagatcagca gagtggaggc cgaggatctg     1800

ggcgtgtact attgctggca gggaacccac ttcccacaca ccttcggcgg cggcaccaag     1860

ctggagatca agcggacagt ggccgcccct tccgtgttca tctttccacc ctctgacgag     1920

cagctgaaga gcggaaccgc atccgtggtg tgcctgctga acaatttcta tcctcgcgag     1980

gccaaggtgc agtggaaggt ggataacgcc ctgcagtctg gcaatagcca ggagtccgtg     2040

acagagcagg actctaagga tagcacctac tccctgagct ccaccctgac actgtccaag     2100

gccgactacg agaagcacaa ggtgtatgcc tgcgaggtga cacaccaggg cctgtctagc     2160

ccagtgacca agagctttaa taggggcgag tgt                                  2193


<210>  113
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8A9F9-LALA Amino Acid Sequence

<400>  113

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ala Asp Tyr Glu 
                725                 730                 735     


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
            740                 745                 750         


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        755                 760             


<210>  114
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8A9F9-LALA Nucleic Acid Sequence

<400>  114
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgaagcccg gcggctctct gaagctgagc      120

tgcgccgcct ccggcttcac cttcagcagc tacgccatgt cctgggtgcg gcagtctcca      180

gagaagcgcc tggagtgggt ggccgagatc tctagcggcg gctcctacac ctactatccc      240

gacaccgtga caggcaggtt cacaatctct agagataacg ccaagaatac cctgtatctg      300

gagatgtcct ctctgcgcag cgaggacaca gccatgtact attgcgccag cgatggctac      360

tattcccact ggggacaggg cacctccgtg acagtgagct ccgcctctac caagggccct      420

agcgtgtttc cactggcccc ctctagcaag tctaccagcg gcggcacagc cgccctggga      480

tgtctggtga aggattactt ccccgagcct gtgaccgtgt cctggaactc tggcgccctg      540

accagcggag tgcacacatt tcccgccgtg ctgcagtcct ctggcctgta ctccctgagc      600

tccgtggtca cagtgccttc tagctccctg ggcacccaga catatatctg caacgtgaat      660

cacaagccct ccaataccaa ggtggacaag aaggtggagc ctaagtcttg tgataagacc      720

cacacatgcc ctccctgtcc agcaccagag ctgctgggcg gccctagcgt gttcctgttt      780

ccacccaagc caaaggacac actgatgatc agcagaaccc ctgaggtgac atgcgtggtg      840

gtggacgtgt cccacgagga ccccgaggtg aagttcaact ggtacgtgga tggcgtggag      900

gtgcacaatg ccaagaccaa gcctcgggag gagcagtaca actccacata tcgcgtggtg      960

tctgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtataa gtgcaaggtg     1020

tctaataagg ccctgcctgc cccaatcgag aagacaatca gcaaggccaa gggccagcct     1080

agggagccac aggtgtacac cctgcctcca tctagagacg agctgacaaa gaaccaggtg     1140

agcctgacct gtctggtgaa gggcttctat ccaagcgata tcgccgtgga gtgggagtcc     1200

aatggccagc ccgagaacaa ttacaagacc acaccccctg tgctggacag cgatggctcc     1260

ttctttctgt attctaagct gaccgtggac aagagcaggt ggcagcaggg caacgtgttt     1320

tcctgctctg tgatgcacga ggccctgcac aatcactaca cacagaagag cctgtccctg     1380

tctccaggca agaggggaag gaagaggaga agcggctccg gagcaaccaa cttcagcctg     1440

ctgaagcagg caggcgatgt ggaggagaat ccaggaccta tggtgctgca gacacaggtg     1500

tttatcagcc tgctgctgtg gatctccgga gcatacggcg acgtggtcat gacccagatc     1560

cccctgtctc tgcctgtgag cctgggcgat caggcctcta tcagctgtag gtctagccag     1620

tccctggtgc actctaacgg caatacctac ctgcactggt atctgcagaa gccaggccag     1680

tcccccaagc tgctgatcta caaggtgagc aacaggttct ccggcgtgcc cgacagattt     1740

tccggctctg gcagcggcac cgatttcaca ctgaagatca gccgggtgga ggcagaggac     1800

ctgggcgtgt atttctgctt tcagtccacc cacgtgcctc ccaccttcgg cggcggcacc     1860

aagctggaga tcaagcgcac agtggccgcc ccttccgtgt tcatctttcc tccatctgac     1920

gagcagctga agtctggcac cgccagcgtg gtgtgcctgc tgaacaattt ctacccaagg     1980

gaggccaagg tgcagtggaa ggtggataac gccctgcagt ctggcaatag ccaggagtcc     2040

gtgacagagc aggactctaa ggatagcacc tattccctgt cctctaccct gacactgagc     2100

aaggccgatt acgagaagca caaggtgtat gcctgcgagg tgacacacca gggcctgagc     2160

tcccccgtga ccaagtcctt taatagaggc gagtgt                               2196


