                         SEQUENCE LISTING

<110>  CARIBOU BIOSCIENCES, INC
 
<120>  ENGINEERED CASCADE COMPONENTS AND CASCADE COMPLEXES

<130>  CBI032.30

<150>  US 16/420,061
<151>  2019-05-22

<150>  US 16/262,773
<151>  2019-01-30

<150>  US 16/104,875
<151>  2018-08-17

<150>  US 62/807,717
<151>  2019-02-19

<150>  US 62/684,735
<151>  2018-06-13

<160>  1927  

<170>  PatentIn version 3.5

<210>  1
<211>  1509
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1509)
<223>  Cas8

<400>  1
atgaatttgc ttattgataa ctggatccct gtacgcccgc gaaacggggg gaaagtccaa       60

atcataaatc tgcaatcgct atactgcagt agagatcagt ggcgattaag tttgccccgt      120

gacgatatgg aactggccgc tttagcactg ctggtttgca ttgggcaaat tatcgccccg      180

gcaaaagatg acgttgaatt tcgacatcgc ataatgaatc cgctcactga agatgagttt      240

caacaactca tcgcgccgtg gatagatatg ttctacctta atcacgcaga acatcccttt      300

atgcagacca aaggtgtcaa agcaaatgat gtgactccaa tggaaaaact gttggctggg      360

gtaagcggcg cgacgaattg tgcatttgtc aatcaaccgg ggcagggtga agcattatgt      420

ggtggatgca ctgcgattgc gttattcaac caggcgaatc aggcaccagg ttttggtggt      480

ggttttaaaa gcggtttacg tggaggaaca cctgtaacaa cgttcgtacg tgggatcgat      540

cttcgttcaa cggtgttact caatgtcctc acattacctc gtcttcaaaa acaatttcct      600

aatgaatcac atacggaaaa ccaacctacc tggattaaac ctatcaagtc caatgagtct      660

atacctgctt cgtcaattgg gtttgtccgt ggtctattct ggcaaccagc gcatattgaa      720

ttatgcgatc ccattgggat tggtaaatgt tcttgctgtg gacaggaaag caatttgcgt      780

tataccggtt ttcttaagga aaaatttacc tttacagtta atgggctatg gccccatccg      840

cattcccctt gtctggtaac agtcaagaaa ggggaggttg aggaaaaatt tcttgctttc      900

accacctccg caccatcatg gacacaaatc agccgagttg tggtagataa gattattcaa      960

aatgaaaatg gaaatcgcgt ggcggcggtt gtgaatcaat tcagaaatat tgcgccgcaa     1020

agtcctcttg aattgattat ggggggatat cgtaataatc aagcatctat tcttgaacgg     1080

cgtcatgatg tgttgatgtt taatcagggg tggcaacaat acggcaatgt gataaacgaa     1140

atagtgactg ttggtttggg atataaaaca gccttacgca aggcgttata tacctttgca     1200

gaagggttta aaaataaaga cttcaaaggg gccggagtct ctgttcatga gactgcagaa     1260

aggcatttct atcgacagag tgaattatta attcccgatg tactggcgaa tgttaatttt     1320

tcccaggctg atgaggtaat agctgattta cgagacaaac ttcatcaatt gtgtgaaatg     1380

ctatttaatc aatctgtagc tccctatgca catcatccta aattaataag cacattagcg     1440

cttgcccgcg ccacgctata caaacattta cgggagttaa aaccgcaagg agggccatca     1500

aatggctga                                                             1509


<210>  2
<211>  483
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Cse2

<400>  2
atggctgatg aaattgatgc aatggcttta tatcgagcct ggcaacaact ggataatgga       60

tcatgtgcgc aaattagacg tgtttcagaa cctgatgaat tacgcgatat ccctgcgttt      120

tataggctgg tgcaaccttt tggttgggaa aacccacgtc accagcaggc tcttttgcgc      180

atggtgtttt gcctgagcgc aggaaagaat gtcatccgac atcaggacaa aaaatcggag      240

caaacaacag gtatctcgtt gggaagagct ttagccaata gtggaagaat taacgagcgc      300

cgtatctttc aattaattcg ggctgacaga acagccgata tggtccagtt acgtcgatta      360

cttactcacg ccgaacccgt acttgactgg ccattaatgg ccaggatgtt gacctggtgg      420

ggaaagcgcg aacgccagca acttctggaa gattttgtat tgaccacaaa caaaaatgcg      480

taa                                                                    483


<210>  3
<211>  1092
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1092)
<223>  Cas7

<400>  3
atgtctaact ttatcaatat tcatgttctg atctctcaca gcccttcatg tctgaaccgc       60

gacgatatga acatgcagaa agacgctatt ttcggcggca aaagacgagt aagaatttca      120

agtcaaagcc ttaaacgtgc gatgcgtaaa agtggttatt acgcacaaaa tattggtgaa      180

tccagtctca gaaccattca tcttgcacaa ttacgtgatg ttcttcggca aaaacttggt      240

gaacgttttg accaaaaaat catcgataag acattagcgc tgctctccgg taaatcagtt      300

gatgaagccg aaaagatttc tgccgatgcg gttactccct gggttgtggg agaaatagcc      360

tggttctgtg agcaggttgc aaaagcagag gctgataatc tggatgataa aaagctgctc      420

aaagttctta aggaagatat tgccgccata cgtgtgaatt tacagcaggg tgttgatatt      480

gcgcttagtg gaagaatggc aaccagcggc atgatgactg agttgggaaa agttgatggt      540

gcaatgtcca ttgcgcatgc gatcactact catcaggttg attctgatat tgactggttc      600

accgctgtag atgatttaca ggaacaaggt tctgcacatc tgggaactca ggaattttca      660

tcgggtgttt tttatcgtta tgccaacatt aacctcgctc aacttcagga aaatttaggt      720

ggtgcctcca gggagcaggc tctggaaatt gcaacccatg ttgttcatat gctggcaaca      780

gaggtccctg gagcaaaaca gcgtacttat gccgctttta accctgcgga tatggtaatg      840

gttaatttct ccgatatgcc actttctatg gcaaatgctt ttgaaaaagc ggttaaagcg      900

aaagatggct ttttgcaacc gtctatacag gcgtttaatc aatattggga tcgcgttgcc      960

aatggatatg gtctgaacgg agctgctgcg caattcagct tatctgatgt agacccaatt     1020

actgctcaag ttaaacaaat gcctacttta gaacagttaa aatcctgggt tcgtaataat     1080

ggcgaggcgt ga                                                         1092


<210>  4
<211>  675
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(675)
<223>  Cas5

<400>  4
atgagatctt atttgatctt gcggcttgct gggccaatgc aagcctgggg gcagccgacc       60

tttgaaggaa cgcgacctac cggaagattt ccgacccgaa gcgggttatt agggctactc      120

ggggcttgtc ttgggatcca acgtgatgat acttcttcat tacaggcgtt atcagagagt      180

gtgcaatttg cagtgcgctg cgatgaactc attcttgacg atcgtcgtgt gtctgtaacg      240

gggttgcgtg attaccatac agtccttgga gcgcgagaag attaccgtgg tttgaaaagt      300

catgaaacga ttcaaacatg gcgcgaatat ttatgtgatg cctcctttac cgtcgctctc      360

tggttaacac cccatgcaac gatggttatc tcagaacttg aaaaagcagt attaaagcct      420

cggtatacac cttacctggg gcggagaagt tgcccactaa cacacccgct ttttttgggg      480

acatgtcagg catcggatcc tcagaaggcg ctattaaatt atgagcccgt tggcggcgat      540

atatatagtg aggaatcagt tacagggcat catttaaaat ttacggcgcg cgacgaaccg      600

atgatcacct tgcctcgaca atttgcttcc cgagaatggt atgtgattaa aggaggtatg      660

gatgtatctc agtaa                                                       675


<210>  5
<211>  600
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(600)
<223>  Cas6

<400>  5
atgtatctca gtaaagtcat cattgccagg gcctggagca gggatcttta ccaacttcac       60

cagggattat ggcatttatt tccaaacaga ccggatgctg ctcgtgattt tctttttcat      120

gttgagaagc gaaacacacc agaaggctgt catgttttat tgcagtcagc gcaaatgcct      180

gtttcaactg ccgttgcgac agtcattaaa actaaacagg ttgaatttca acttcaggtt      240

ggtgttccac tctattttcg gcttcgggca aatccgatca aaactattct cgacaatcaa      300

aagcgcctgg acagtaaagg gaatattaaa cgctgtcggg ttccgttaat aaaagaagca      360

gaacaaatcg cgtggttgca acgtaaattg ggcaatgcgg cgcgcgttga agatgtgcat      420

cccatatcgg aacggccaca gtatttttct ggtgatggta aaagtggaaa gatccaaacg      480

gtttgctttg aaggtgtgct caccatcaac gacgcgccag cgttaataga tcttgtacag      540

caaggtattg ggccagctaa atcgatggga tgtggcttgc tatctttggc tccactgtga      600


<210>  6
<211>  1509
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1509)
<223>  Cas8

<400>  6
atgaatctgc tgattgataa ttggattccg gttcgtccgc gtaatggtgg taaagttcag       60

attattaatc tgcagagcct gtattgtagc cgtgatcagt ggcgtctgag cctgccgcgt      120

gatgatatgg aactggcagc actggcactg ctggtttgta ttggtcagat tattgcaccg      180

gcaaaagatg atgttgaatt tcgccatcgt attatgaatc cgctgaccga agatgaattt      240

cagcagctga ttgccccgtg gattgatatg ttttatctga atcatgcaga acatccgttt      300

atgcagacca aaggtgttaa agcaaatgat gttaccccga tggaaaaact gctggccggt      360

gttagcggtg caaccaattg tgcatttgtt aatcagccgg gtcagggtga agcactgtgt      420

ggtggttgta ccgcaattgc actgtttaat caggcgaatc aggccccggg ttttggtggt      480

ggttttaaaa gcggtctgcg tggtggtaca ccggttacca cctttgttcg tggtattgat      540

ctgcgtagca ccgttctgct gaatgttctg accctgccgc gtctgcagaa acagtttccg      600

aatgaaagcc ataccgaaaa tcagccgacc tggattaaac cgattaaaag caatgaaagc      660

attccggcaa gcagcattgg ttttgtgcgt ggtctgtttt ggcagccggc acatattgaa      720

ctgtgtgatc cgattggtat tggtaaatgt agctgttgtg gtcaggaaag caatctgcgt      780

tataccggct ttctgaaaga gaaatttacc tttaccgtta atggtctgtg gccgcatccg      840

catagcccgt gtctggttac cgtgaaaaaa ggtgaagttg aagaaaaatt tctggcattt      900

accaccagcg caccgagctg gacccagatt agccgtgttg ttgttgataa aattattcag      960

aatgaaaatg gcaatcgtgt tgcagcagtt gtgaatcagt ttcgtaatat tgcgccgcag     1020

agcccgctgg aactaattat gggtggttat cgtaataatc aggcaagcat tctggaacgc     1080

cgtcatgatg ttctgatgtt taatcagggt tggcagcagt atggtaatgt gattaatgaa     1140

attgtgaccg ttggtctggg ctataaaacc gcactgcgta aagcgctgta tacctttgcc     1200

gaaggcttta aaaacaaaga ttttaaaggt gcaggcgtta gcgttcatga aaccgccgaa     1260

cgtcattttt atcgtcagag cgaactgctg attccggatg tgctggcaaa tgttaatttt     1320

agccaggcag atgaagttat tgcagatctg cgcgataaac tgcatcagct gtgtgaaatg     1380

ctgtttaatc agagcgttgc accgtatgca catcatccga aactgattag caccctggcc     1440

ctggcacgtg caaccctgta taaacatctg cgtgaactga aaccgcaggg tggtccgagc     1500

aatggttaa                                                             1509


<210>  7
<211>  483
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Cse2

<400>  7
atggcagatg aaattgatgc aatggcactg tatcgtgcat ggcagcagct ggataatggt       60

agctgtgcac agattcgtcg tgttagcgaa ccggatgaac tgcgtgatat tccggcattt      120

tatcgtctgg ttcagccgtt tggttgggaa aatccgcgtc atcagcaggc actgctgcgt      180

atggtttttt gtctgagcgc aggtaaaaat gttattcgtc atcaggataa aaaaagcgaa      240

cagaccaccg gtattagcct gggtcgtgca ctggcaaata gcggtcgtat taatgaacgt      300

cgtatttttc agctgattcg tgcagatcgt accgcagata tggttcagct gcgtcgtctg      360

ctgacccatg cagaaccggt tctggattgg ccgctgatgg cacgtatgct gacctggtgg      420

ggtaaacgtg aacgtcagca gctgctggaa gattttgttc tgaccaccaa taaaaatgcc      480

taa                                                                    483


<210>  8
<211>  1092
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1092)
<223>  Cas7

<400>  8
atgagcaact ttattaatat tcatgtgctg attagccata gcccgagctg cctgaatcgt       60

gatgatatga atatgcagaa agatgccatt tttggcggta aacgtcgtgt tcgtattagc      120

agccagagcc tgaaacgtgc aatgcgtaaa agcggttatt atgcacagaa tattggtgaa      180

agcagcctgc gtaccattca tctggcacag ctgcgtgatg ttctgcgtca gaaactgggt      240

gaacgttttg atcagaaaat tattgataaa accctggcac tgctgagtgg caaaagcgtt      300

gatgaagcag aaaaaattag cgcagatgca gttaccccgt gggttgttgg tgaaattgcc      360

tggttttgcg aacaggttgc caaagccgaa gcagataatc tggatgataa aaaactgctg      420

aaagttctga aagaagatat tgccgccatt cgtgttaatc tgcagcaggg tgttgatatt      480

gcactgagcg gtcgtatggc aaccagcggt atgatgaccg aactgggtaa agttgatggt      540

gcaatgagca ttgcacatgc aattaccacc catcaggttg atagcgatat tgattggttt      600

accgcagttg atgatctgca ggaacagggt agcgcacatc tgggtacaca ggaatttagc      660

agcggtgtgt tttatcgtta tgcaaatatt aatctggccc agctgcagga aaatctgggt      720

ggtgcaagcc gtgaacaggc actggaaatt gcaacccatg ttgttcatat gctggcaacc      780

gaagttccgg gtgcaaaaca gcgtacctat gcagccttta atccggcaga tatggttatg      840

gttaatttta gcgatatgcc gctgtcaatg gcaaatgcct ttgaaaaagc agtgaaagcc      900

aaagatggtt ttctgcagcc gagcattcag gcatttaatc agtattggga tcgtgttgca      960

aatggctatg gtctgaatgg tgcagcagca cagtttagcc tgagcgatgt tgatccgatt     1020

accgcacagg ttaaacagat gccgaccctg gaacagctga aaagctgggt tcgtaataat     1080

ggtgaagcat aa                                                         1092


<210>  9
<211>  675
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(675)
<223>  Cas5

<400>  9
atgcgtagct atctgattct gcgtctggca ggtccgatgc aggcatgggg tcagccgaca       60

tttgaaggta cacgtccgac aggtcgtttt ccgacacgta gtggtctgct gggtctgctg      120

ggtgcatgtc tgggtattca gcgtgatgat accagcagtc tgcaggcact gagcgaaagc      180

gtgcagtttg cagttcgttg tgatgaactg attctggatg atcgtcgtgt tagcgtgacc      240

ggtctgcgtg attatcatac cgttctgggt gcacgtgaag attatcgtgg tctgaaaagc      300

catgaaacca ttcagacctg gcgtgaatat ctgtgtgatg caagttttac cgttgcactg      360

tggctgaccc cgcatgcaac aatggttatt agcgaactgg aaaaagcagt tctgaaaccg      420

cgttataccc cgtatctggg tcgtcgtagc tgtccgctga cccatccgct gtttctgggt      480

acatgtcagg caagcgatcc gcagaaagca ctgctgaatt atgaaccggt tggtggtgat      540

atttatagcg aagaaagcgt taccggtcat catctgaaat ttaccgcacg tgatgaaccg      600

atgattaccc tgccgcgtca gtttgcaagc cgtgaatggt atgttattaa aggtggtatg      660

gatgttagcc agtaa                                                       675


<210>  10
<211>  600
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(600)
<223>  Cas6

<400>  10
atgtatctga gcaaagttat tattgcacgt gcatggagcc gtgatctgta tcagctgcat       60

cagggtctgt ggcatctgtt tccgaatcgt ccggatgcag cccgtgattt tctgtttcat      120

gttgaaaaac gtaatacccc ggaaggttgt catgttctgc tgcagagcgc acagatgccg      180

gttagcaccg cagttgcaac cgttattaaa accaaacagg tggaatttca gctgcaggtt      240

ggtgttccgc tgtattttcg tctgcgtgcc aatccgatta aaaccattct ggataatcag      300

aaacgtctgg atagcaaagg taatattaaa cgttgccgcg tgccgctgat taaagaagcc      360

gaacagattg catggctgca gcgtaaactg ggtaatgcag cacgtgttga agatgttcat      420

ccgattagcg aacgtccgca gtattttagc ggtgatggta aaagcggtaa aattcagacc      480

gtttgttttg aaggtgttct gaccattaat gatgcaccgg cactgattga tctggttcag      540

cagggtattg gtccggcaaa aagcatgggt tgtggtctgc tgagtctggc cccgctgtaa      600


<210>  11
<211>  1509
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1509)
<223>  Cas8

<400>  11
atgaatttgc tcattgataa ttggattccg gtgcgccccc ggaacggtgg gaaagtgcag       60

atcatcaatt tgcaaagtct ctactgttcc agggaccagt ggagactcag cctgccacgg      120

gatgatatgg agctggcggc gttggctctg ctcgtatgca tcggccagat tattgcgcca      180

gcaaaggatg acgttgaatt ccggcatcgg ataatgaacc cccttactga agatgagttc      240

cagcagctta tcgccccatg gatcgacatg ttctacctca accacgccga gcatcctttt      300

atgcagacca agggagtcaa ggcgaatgat gtgactccca tggagaagct gctggccggt      360

gtatctgggg cgaccaactg cgcattcgtg aatcagcctg gacaggggga ggccctctgt      420

ggaggctgca ctgctatagc actttttaac caagctaatc aagcccccgg ctttggtgga      480

gggtttaaga gtggattgag ggggggcact cccgtaacca cttttgtgag gggaattgat      540

ctgaggtcta ctgtgttgct gaacgtcctc acactcccaa ggctccagaa gcagttccca      600

aacgaaagtc ataccgaaaa ccagcccaca tggatcaagc ccatcaaatc taatgagagc      660

ataccggcta gcagtattgg atttgtacgg ggtctgttct ggcagccagc tcacatcgag      720

ctgtgtgatc ctattgggat cggcaagtgc tcttgttgtg ggcaggagtc caaccttagg      780

tatactggat ttctgaaaga gaagtttacc tttacagtaa atgggctctg gccccacccc      840

cactcacctt gccttgtgac agtgaaaaag ggggaagtcg aggagaagtt tctggccttt      900

acaacttctg ccccttcctg gactcagatt tccagagtgg tggtagataa gataattcaa      960

aacgagaatg gcaatagagt ggccgccgtg gtgaaccagt ttcgcaacat cgcccctcag     1020

tcccccctgg agctgattat gggcggttat cggaataacc aggccagtat actcgagcga     1080

cggcacgatg tcctcatgtt caatcaaggt tggcagcaat atggcaatgt gattaacgag     1140

atcgtaaccg tgggcctggg atataagacc gccctgcgga aggcgttgta tacttttgca     1200

gaaggcttta agaataagga ttttaagggt gccggcgtga gtgtccatga aacagctgaa     1260

cggcactttt atcggcagtc cgagctgttg ataccagacg tgctggctaa tgtgaacttc     1320

tcacaggccg acgaagtgat cgctgatctg cgggataaac tgcaccaact gtgcgagatg     1380

ctgtttaatc aaagcgtcgc tccttatgcc caccacccaa agctgatctc cacgctggcc     1440

ctggcgcgcg ccacacttta taaacatctc cgcgaactga aaccccaggg gggccccagc     1500

aatggctaa                                                             1509


<210>  12
<211>  483
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Cse2

<400>  12
atggccgacg agattgacgc aatggcactt taccgggcct ggcagcagtt ggataatggt       60

tcatgtgccc agattcgcag agttagtgaa cctgacgaac tgagagatat ccccgcgttt      120

tacagacttg tccaaccgtt cggatgggag aacccacggc accaacaagc actccttcga      180

atggtcttct gtttgtccgc aggaaaaaat gtaatcagac accaagacaa aaagagcgag      240

caaaccacag gtatcagcct gggcagggca cttgccaact ctgggcggat caacgaaagg      300

agaatttttc agctgatacg cgctgatcgg actgcggaca tggtgcagct gcgcagactc      360

cttactcatg ccgaacctgt cctggattgg cccctgatgg cacgcatgct gacttggtgg      420

ggaaagagag aaagacagca actgcttgaa gacttcgtgc tcactacaaa taagaatgcc      480

taa                                                                    483


<210>  13
<211>  1092
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1092)
<223>  Cas7

<400>  13
atgtcaaatt ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga       60

gacgacatga atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc      120

agccaaagtc ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag      180

tcctcattgc ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg      240

gaaagattcg accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg      300

gacgaggctg aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct      360

tggttttgtg aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg      420

aaggtcctta aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc      480

gcattgtccg gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga      540

gccatgagta tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc      600

acagcagtag atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct      660

tccggggtgt tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg      720

ggagcctctc gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca      780

gaggtacctg gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg      840

gtaaatttct ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca      900

aaggacgggt tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg      960

aacggctatg gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata     1020

actgcacagg tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac     1080

ggcgaagcct aa                                                         1092


<210>  14
<211>  675
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(675)
<223>  Cas5

<400>  14
atgcggagct atctcatcct gagactggcc ggaccaatgc aggcctgggg acagcctacc       60

ttcgaaggta cacgccccac aggccgcttt cctaccagga gcggcctgct gggcctgctt      120

ggcgcttgtc ttgggatcca gcgcgatgat actagctccc tgcaagcact gtcagagagc      180

gtgcagtttg ccgtaagatg cgacgaactg atccttgatg ataggcgggt cagtgtcact      240

ggtctccggg actaccacac ggtgctgggg gcccgggagg attatagggg cctgaaaagt      300

cacgagacga ttcaaacctg gcgcgaatat ctgtgcgatg ccagcttcac cgtggccctg      360

tggctgactc cacatgccac tatggtcatc agtgaactgg aaaaggctgt tcttaagcct      420

cgatatactc cgtatctggg ccgccggagt tgtccactta cacacccact tttcctcggc      480

acctgccagg ccagcgaccc tcaaaaggcc cttctgaatt acgagccagt tggcggtgac      540

atatacagcg aagagtccgt gacgggacac catcttaagt tcaccgctcg ggacgagccc      600

atgattaccc tcccacggca gttcgcatca agggagtggt acgtcataaa ggggggcatg      660

gatgtgagtc agtaa                                                       675


<210>  15
<211>  600
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(600)
<223>  Cas6

<400>  15
atgtatctgt caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac       60

cagggtctgt ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac      120

gttgaaaaaa gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg      180

gtgagcacag ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta      240

ggggttccac tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag      300

aagaggctcg acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct      360

gagcaaatcg cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac      420

ccgattagtg aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca      480

gtctgtttcg agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag      540

cagggcatag gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctgtaa      600


<210>  16
<211>  502
<212>  PRT
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(502)
<223>  Cas8

<400>  16

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly 
            500         


<210>  17
<211>  160
<212>  PRT
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(160)
<223>  Cse2

<400>  17

Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln 
1               5                   10                  15      


Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp 
            20                  25                  30          


Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly 
        35                  40                  45              


Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys 
    50                  55                  60                  


Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu 
65                  70                  75                  80  


Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg 
                85                  90                  95      


Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala 
            100                 105                 110         


Asp Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu 
        115                 120                 125             


Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu 
    130                 135                 140                 


Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
145                 150                 155                 160 


<210>  18
<211>  363
<212>  PRT
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Cas7

<400>  18

Met Ser Asn Phe Ile Asn Ile His Val Leu Ile Ser His Ser Pro Ser 
1               5                   10                  15      


Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly 
            20                  25                  30          


Gly Lys Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met 
        35                  40                  45              


Arg Lys Ser Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg 
    50                  55                  60                  


Thr Ile His Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly 
65                  70                  75                  80  


Glu Arg Phe Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser 
                85                  90                  95      


Gly Lys Ser Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr 
            100                 105                 110         


Pro Trp Val Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys 
        115                 120                 125             


Ala Glu Ala Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys 
    130                 135                 140                 


Glu Asp Ile Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile 
145                 150                 155                 160 


Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly 
                165                 170                 175     


Lys Val Asp Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Gln 
            180                 185                 190         


Val Asp Ser Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu 
        195                 200                 205             


Gln Gly Ser Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe 
    210                 215                 220                 


Tyr Arg Tyr Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly 
225                 230                 235                 240 


Gly Ala Ser Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Val His 
                245                 250                 255     


Met Leu Ala Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala 
            260                 265                 270         


Phe Asn Pro Ala Asp Met Val Met Val Asn Phe Ser Asp Met Pro Leu 
        275                 280                 285             


Ser Met Ala Asn Ala Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe 
    290                 295                 300                 


Leu Gln Pro Ser Ile Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala 
305                 310                 315                 320 


Asn Gly Tyr Gly Leu Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp 
                325                 330                 335     


Val Asp Pro Ile Thr Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln 
            340                 345                 350         


Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala 
        355                 360             


<210>  19
<211>  224
<212>  PRT
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(224)
<223>  Cas5

<400>  19

Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro Met Gln Ala Trp 
1               5                   10                  15      


Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly Arg Phe Pro Thr 
            20                  25                  30          


Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu Gly Ile Gln Arg 
        35                  40                  45              


Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser Val Gln Phe Ala 
    50                  55                  60                  


Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg Val Ser Val Thr 
65                  70                  75                  80  


Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg Glu Asp Tyr Arg 
                85                  90                  95      


Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg Glu Tyr Leu Cys 
            100                 105                 110         


Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro His Ala Thr Met 
        115                 120                 125             


Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro Arg Tyr Thr Pro 
    130                 135                 140                 


Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro Leu Phe Leu Gly 
145                 150                 155                 160 


Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu Asn Tyr Glu Pro 
                165                 170                 175     


Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr Gly His His Leu 
            180                 185                 190         


Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu Pro Arg Gln Phe 
        195                 200                 205             


Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met Asp Val Ser Gln 
    210                 215                 220                 


<210>  20
<211>  199
<212>  PRT
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(199)
<223>  Cas6

<400>  20

Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu 
1               5                   10                  15      


Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn Arg Pro Asp 
            20                  25                  30          


Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn Thr Pro Glu 
        35                  40                  45              


Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val Ser Thr Ala 
    50                  55                  60                  


Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln Leu Gln Val 
65                  70                  75                  80  


Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile 
                85                  90                  95      


Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile Lys Arg Cys 
            100                 105                 110         


Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp Leu Gln Arg 
        115                 120                 125             


Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro Ile Ser Glu 
    130                 135                 140                 


Arg Pro Gln Tyr Phe Ser Gly Asp Gly Lys Ser Gly Lys Ile Gln Thr 
145                 150                 155                 160 


Val Cys Phe Glu Gly Val Leu Thr Ile Asn Asp Ala Pro Ala Leu Ile 
                165                 170                 175     


Asp Leu Val Gln Gln Gly Ile Gly Pro Ala Lys Ser Met Gly Cys Gly 
            180                 185                 190         


Leu Leu Ser Leu Ala Pro Leu 
        195                 


<210>  21
<211>  888
<212>  PRT
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(888)
<223>  Cas3

<400>  21

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  22
<211>  1455
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(1455)
<223>  Cas8

<400>  22
atgacggttt cgttgaatct gatcactgac cgctggatcc ccgtcctaga caccacaggc       60

acccgccata cgattgcacc ctgggagatg gccgattcct cgttcgtcgc cccggactgg      120

ccgcgccccg atctgaacac ggcctgcctg gagctgctga tcggcctcgt ccgtctggcc      180

gatccgcctg cccatcccga cgattgggag gataggcaag ctccggatgc tgatcgcttg      240

cgcgaccgcc ttgctccttt cgccccagcc ttcaaccttc tgggtgatgg gccgcggttc      300

atgcaggaaa tgggggggct ggttggcgat gtccgagcca ctgacgtgct tttcattgat      360

tccggtggtg atggcggtgc gctgacagtg cgtgaaggac gataccccaa cctggacctg      420

cccacggcgg caatggcgct ttatgccatg cagacgcagg ccccatcggg tggacggggt      480

aatctgacat cgctgcgcgg cggcggcccg atgacggtgc tggtcgatcc aggtggcggg      540

atgtggcctc tcatttgggc caacgtgcca gacggcaaac ctgtcgtgcc aaatgttctg      600

ccatggatga ggcgcacggt gacttcagaa actggagtgc ggttcttccc acatcaagga      660

gatgcagccg aggtgttctt cggtatgccg cgtcggttgt ggctagaggc tcggaacgac      720

agtgtcactg gggtgatcca gcgaccctcc ggcacgaaat acgtgggctg gcgtcatccc      780

ctgacgccct actatcgcca gaaggcgggt gacacgccgc tacctgtgcg gccgcgcgcc      840

ggggtgtttg gttatcgcca ctggctaggt attgctgccg aacagggcag tgatctgcgc      900

gagcgccctg cgacggtaga ggcgtgggaa agtcgcggtc ttggccgccg agctgacatc      960

attgtggccg gctgggcaat ggagaacatg aaggctcgcg attacatatg gtcgcgggcg     1020

ccgctggtga ccctgcccga agagcgagcg gcctttctcc gcgatatgat cgaagcggcc     1080

gatttacttt cggcagccct gcgtggtgcc ctagccacgc ttctgggcga gggagagggg     1140

cgtgaggcgg cgcgggaagc gttctatgtc cgcacgcagg ccgccttcga ggggtgggtt     1200

tcttgtctgg ataccattgc tctggacgcc gctgcgcgtg gctggctggc cgacatgcgc     1260

aaggtggcgc tggagatttt cgaggtgctg gcgctgcccg gtttggcgga tcgcactatc     1320

ctcgttcaac aggaaatcgt cgccgcgcat cgcgggctga ccggcagctt ctcgggctat     1380

ggaaagcttg ggaccaaggc gtttggcgtt ctgaacctac ctgtgccgac acgcaagaag     1440

gaggcggcga catga                                                      1455


<210>  23
<211>  525
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(525)
<223>  Cse2

<400>  23
atgagcgatc gcaagcaggt catcggcaca tggtggcgga ccaggattgg tgcccgcaac       60

tccaccgcgg cgcgtgcgct ggcggccagg ctgaaccggg gcgagggggt ggacgtgctc      120

gcggagcggg cagtcttcga gcttggccgg gacttgggct tcctgaagca acccaaacgt      180

ctggtgctgc ttgtgcgggt gctggcggcg gtgcgtgagg atcggggggg agcgttgcca      240

ctaagactgg ggcaggggga tcctccaccc ctatcgccgt tgcgttttca gcgtcttttg      300

cgcgccgaag gcgaggagtt gaccacgctt ctgcgccgcg ccctccctat ggtcacacgg      360

acctgcgacg tgggcgcgct tggcgccgat ctgcttgact ggtctgactc cacccgcgcc      420

cgctgggcct tcgcctattt cggcgcgacc ccgcccgcca gaatcaacaa ctccagacca      480

acccctgaaa cgcccgccct atccgatcag gagaccgagg aatga                      525


<210>  24
<211>  1083
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(1083)
<223>  Cas7

<400>  24
atgacgacct ttttgcaatt tcatgtgctg acgacctatc ccccgtcgaa ccctaaccgc       60

gacgatcagg gccgtccgaa gcaggccaat ctcggcggcg ctccccggct acggctatcg      120

tcgcaatcga tcaagcgggc aatgcgtgag agcccggcat ttcagcaggg tcttgatggc      180

catatcggca cgcgaacgaa gcgactgggc gaagaaatcc gcgaagagtt ggccaagcga      240

gagggcgtgt cgaccgatca ggcgctcgat gtggcttcaa aggtcgccgc gatcttctct      300

aagctggagg cgccgggcaa ggataaggtg caaaaaccac ttaccaccac tctggccttc      360

gtgtcgcccg acgaatgggc attggcccgc gatctggcga gccggatgtt ggcgggcgag      420

gagatgccga aggacaagga actgaagcgt ctggttctcc gccgtgccga cggggcagtg      480

gatatcgcca tgttcggccg gatgctggcg gatgaaccgg gctacaaccg cgaggccgcc      540

gtgcaggtga gccacgccat caccacccat cgcgccattg ccgaggacga ttggtattcc      600

gccgtcgacg atcttaacaa gcgcgaggat tcaggtgccg gacacttggg cgagcatggt      660

ttcggttcgg gcgtctatta cctctatgcc tgcgtcaacg tcgatcttct ggtagagaac      720

ctcgcgggcg atcgggcact cgccgcccgt ggtctcgaag cgttggcaaa ggcgctcgct      780

accgcaacac cacgcgggaa gcagaacagc catgcccacc acccccgcgc gatctatgtc      840

cgcgccgaac gcgggccgca acagccgcgc gacctgaccg gggccttctt ttctgctgtg      900

gacctgaagt cgaatgacat cgagcggaca tcaatcatcg cactggagag aaccgccgaa      960

cagattgatc gcgcctacgg tgccgcttgt gacgataccg cggtaatgga cgtgaaggag     1020

gggaatggca ctctggccga gatcgctgcc ttttctggcg cgtcggtatc tgccaatgcg     1080

tga                                                                   1083


<210>  25
<211>  765
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(765)
<223>  Cas5

<400>  25
atggcactct ggccgagatc gctgcctttt ctggcgcgtc ggtatctgcc aatgcgtgag       60

catttggtct ttaccttggc cgcggctgtc gcctcgatgg gcgaactggc agggcacgag      120

cggcgtggca cctggtcttg gccgggacgg tcgtcagttc tgggcttgtg cgcagcagcc      180

cttggtatcc ggcgtgatgg cgatttcagt gcgcttgacg gactcgggct ggcagtggct      240

gtgttcgata caggcgaacc gctgcgggat tttcacacag ccgtcagtat cccgtcgtca      300

gtagcaaaga gaccgcagtc gcgtgcagat gcgttgcgga tcgacgctgg acgcagcaat      360

tccacgatca cattgcgcga ttaccgggtc ggagtgcttt atggtgtcgc gttgtggggc      420

gacggcctcc cgactgttgc agagaatctg gtcgaggctc tgcaacggcc gaccttcacg      480

ctctacttgg ggcgtaagtc ctgccccttg gcggccccgc ttgcgccacg tgtcctgacg      540

gcacccgacg ctgcggcggc gctgacagac ggaatgacgc taccaccgtg gcgtgctggt      600

gcccgtgcag gccagatcgc taccgaagag gaattgcccg cacctcgcac ggaaacccgc      660

cacgaccggc ccactgatcg caccgcatgg catttcgccc cgcgcgcggt gcgtctcgtt      720

ccctgtgata tcgcacctcg cactgctgga caggtggctg catga                      765


<210>  26
<211>  708
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(708)
<223>  Cas6

<400>  26
atgaccctct ggctatcccg agtccgcatc gctcgtggtg ctgatcttga tacgctgcgg       60

ccgctcttgg acccaagtgc gctgcatccg gcggcgatgg acccaaagat gttgggctct      120

caaacagacg cgcatcaccg cctgatctgg acgctgtttg ccgatagtcg tgaccggcgc      180

cgcgatttcc tgtggcgagc cgagggtgca gggaagttca ctttgctgtc gctgcgtcca      240

cctacggcgt cacgagtgtt tgaggcaccc gaggtgaagg ctttctctcc tgatcttttg      300

cccggtgacc ggctggcctt cgctttgcgc gccaacgcaa cccgagaccg ggccgggtca      360

gccaagggac ggcgagtcga tgtggtgatg cacgccttgc ataacgtgcc gcccgaggac      420

cgcgctgcgg cccggatgac tctggctcag gacgccgcct cggattggtt gacggggcag      480

ggcgcgcgcg cgggcttcgt gccggaagag gtgacagcag gtgattattc cgtggccgca      540

cttccaagcc acactggtag gcgaaagggg cagccgcagt atggtatcct cgatctgacc      600

ggcgtgctgc gcgtgaccga tccggcggct ttccttgcac ggctgggcca gggctttggt      660

agggcacgtg gttttggttg cgggcttatg ctgatccggc gggcctga                   708


<210>  27
<211>  1455
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(1455)
<223>  Cas8

<400>  27
atgacagtga gcctgaatct gatcaccgat cgctggattc ccgtgctgga cacaaccgga       60

acacggcaca ccatcgcacc ttgggagatg gccgacagct cctttgtggc cccagattgg      120

cccagacctg acctgaacac cgcctgtctg gagctgctga tcggactggt gcgcctggcc      180

gatccccctg cacaccccga cgattgggag gacaggcagg cccctgacgc agataggctg      240

agggatagac tggcaccttt tgccccagcc ttcaatctgc tgggcgacgg cccacgcttc      300

atgcaggaga tgggaggact ggtgggcgat gtgcgggcaa cagacgtgct gtttatcgat      360

tccggcggcg acggaggcgc cctgaccgtg agagagggca ggtacccaaa cctggacctg      420

ccaacagcag caatggcact gtatgcaatg cagacccagg cacctagcgg cggaagagga      480

aatctgacat ccctgagggg aggaggacca atgaccgtgc tggtggaccc cggaggagga      540

atgtggcctc tgatctgggc aaacgtgccc gacggcaagc cagtggtgcc taatgtgctg      600

ccttggatga gaaggacagt gaccagcgag accggcgtga ggttctttcc acaccagggc      660

gatgccgccg aggtgttctt tggaatgcca cgccggctgt ggctggaggc acgcaacgac      720

tccgtgacag gcgtgatcca gcggccctct ggcaccaagt atgtgggctg gcgccaccca      780

ctgacaccct actataggca gaaggcaggc gataccccac tgcccgtgag gcctagggca      840

ggcgtgttcg gatacaggca ctggctggga atcgcagcag agcagggctc tgacctgagg      900

gagagaccag caaccgtgga ggcctgggag agccgcggac tgggcagaag ggccgatatc      960

atcgtggccg gctgggccat ggagaatatg aaggcaaggg actatatctg gtcccgggca     1020

cctctggtga cactgccaga ggagagagcc gcctttctga gggatatgat cgaggccgcc     1080

gacctgctgt ctgccgccct gaggggcgcc ctggccaccc tgctgggcga gggcgagggc     1140

agagaggccg ccagggaggc cttttacgtg agaacacagg ccgccttcga gggctgggtg     1200

agctgtctgg ataccatcgc cctggacgca gcagcaaggg gatggctggc cgatatgcgg     1260

aaggtggccc tggagatctt cgaggtgctg gccctgccag gactggcaga cagaaccatc     1320

ctggtgcagc aggagatcgt ggcagcacac aggggactga caggcagctt ctccggctac     1380

ggcaagctgg gcaccaaggc ctttggcgtg ctgaacctgc ctgtgccaac acggaagaag     1440

gaggccgcca cctaa                                                      1455


<210>  28
<211>  525
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(525)
<223>  Cse2

<400>  28
atgagcgaca ggaagcaggt catcggcaca tggtggagaa ccaggatcgg cgccagaaac       60

tccaccgcag caagggccct ggcagcacgg ctgaatagag gagagggagt ggatgtgctg      120

gcagagaggg ccgtgtttga gctgggaagg gacctgggct tcctgaagca gccaaagcgc      180

ctggtgctgc tggtgcgggt gctggcagcc gtgagggagg ataggggagg cgccctgcct      240

ctgaggctgg gccagggcga ccctccaccc ctgagcccac tgcggtttca gagactgctg      300

agggcagaag gagaggagct gacaaccctg ctgaggcgcg ccctgccaat ggtgacacgc      360

acctgcgacg tgggcgccct gggagcagac ctgctggatt ggtccgactc tacacgcgca      420

agatgggcct ttgcctattt cggcgccacc cctccagcca gaatcaacaa tagcaggcca      480

acacccgaga cccccgccct gtccgatcag gagacagagg agtaa                      525


<210>  29
<211>  1083
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(1083)
<223>  Cas7

<400>  29
atgaccacat ttctgcagtt ccacgtgctg accacatatc ccccttctaa ccctaatagg       60

gacgatcagg gccggccaaa gcaggcaaac ctgggaggag caccaaggct gcggctgagc      120

tcccagtcta tcaagagggc aatgagggag agccctgcat tccagcaggg cctggatgga      180

cacatcggca cacggaccaa gagactgggc gaggagatca gggaggagct ggcaaagagg      240

gagggcgtga gcaccgatca ggccctggac gtggcatcta aggtggcagc catcttcagc      300

aagctggagg cccccggcaa ggacaaggtg cagaagcctc tgaccacaac cctggccttt      360

gtgagcccag atgagtgggc actggcaaga gacctggcat ccaggatgct ggcaggagag      420

gagatgccca aggataagga gctgaagcgc ctggtgctgc ggagagcaga tggagcagtg      480

gacatcgcaa tgttcggaag gatgctggca gacgagccag gatataacag ggaggcagca      540

gtgcaggtga gccacgcaat cacaacccac agagccatcg ccgaggacga ttggtactct      600

gccgtggacg atctgaataa gagggaggat agcggcgcag gacacctggg agagcacgga      660

tttggctccg gcgtgtacta tctgtacgcc tgcgtgaacg tggatctgct ggtggagaat      720

ctggcaggcg accgcgccct ggcagcaagg ggcctggagg ccctggcaaa ggccctggca      780

acagcaaccc caagaggcaa gcagaactct cacgcccacc accccagggc aatctatgtg      840

agggcagaga ggggaccaca gcagcctagg gacctgaccg gcgccttctt ttctgccgtg      900

gatctgaaga gcaatgacat cgagcggaca tccatcatcg ccctggagag aaccgccgag      960

cagatcgata gggcatacgg agcagcatgc gacgatacag ccgtgatgga cgtgaaggag     1020

ggaaacggca ccctggcaga gatcgcagcc ttcagcggcg catctgtgag cgccaatgca     1080

taa                                                                   1083


<210>  30
<211>  765
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(765)
<223>  Cas5

<400>  30
atggcactgt ggcctcggtc tctgccattc ctggcccgga gatacctgcc aatgcgggag       60

cacctggtgt ttacactggc cgccgccgtg gcctccatgg gagagctggc aggacacgag      120

aggaggggca cctggtcttg gcccggcaga tctagcgtgc tgggcctgtg cgcagccgcc      180

ctgggcatcc ggcgggacgg cgatttctcc gccctggacg gactgggact ggcagtggcc      240

gtgtttgata caggagagcc actgagggac ttccacaccg ccgtgtccat cccatcctct      300

gtggccaaga ggccacagtc tcgggcagat gccctgcgca tcgacgcagg ccggagcaac      360

tccacaatca ccctgcgcga ttacagggtg ggcgtgctgt atggagtggc cctgtggggc      420

gacggactgc ctaccgtggc cgagaatctg gtggaggccc tgcagcgccc aacattcacc      480

ctgtacctgg gccggaagag ctgtccactg gcagcaccac tggcaccccg cgtgctgaca      540

gccccagatg cagcagccgc cctgacagac ggaatgaccc tgccaccatg gagagcagga      600

gcaagggcag gccagatcgc aaccgaggag gagctgcctg caccaagaac agagaccaga      660

cacgataggc caacagacag gaccgcctgg cactttgcac caagggccgt gcggctggtg      720

ccttgcgata tcgccccaag aacagcagga caggtggcag cataa                      765


<210>  31
<211>  708
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(708)
<223>  Cas6

<400>  31
atgacactgt ggctgagccg ggtgcggatc gcaagaggag cagacctgga taccctgagg       60

ccactgctgg accccagcgc cctgcaccca gcagcaatgg accccaagat gctgggctcc      120

cagacagacg cccaccacag actgatctgg accctgtttg ccgattccag agacaggcgc      180

cgggacttcc tgtggagggc agagggcgcc ggcaagttta cactgctgag cctgagaccc      240

cctaccgcct ccagggtgtt tgaggcccct gaggtgaagg ccttcagccc agatctgctg      300

ccaggcgaca ggctggcctt cgccctgcgg gccaacgcca cccgcgatcg ggccggctcc      360

gccaagggca gaagggtgga cgtggtcatg cacgccctgc acaatgtgcc acccgaggat      420

agggcagcag caaggatgac actggcacag gatgcagcaa gcgactggct gaccggacag      480

ggagccagag caggattcgt gcccgaggag gtgacagcag gcgactactc cgtggccgcc      540

ctgccttctc acaccggccg gagaaagggc cagccacagt atggcatcct ggatctgaca      600

ggcgtgctga gagtgaccga ccctgcagcc tttctggcaa ggctgggaca gggatttgga      660

agagcaaggg gattcggatg cggactgatg ctgatcagaa gggcataa                   708


<210>  32
<211>  484
<212>  PRT
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(484)
<223>  Cas8

<400>  32

Met Thr Val Ser Leu Asn Leu Ile Thr Asp Arg Trp Ile Pro Val Leu 
1               5                   10                  15      


Asp Thr Thr Gly Thr Arg His Thr Ile Ala Pro Trp Glu Met Ala Asp 
            20                  25                  30          


Ser Ser Phe Val Ala Pro Asp Trp Pro Arg Pro Asp Leu Asn Thr Ala 
        35                  40                  45              


Cys Leu Glu Leu Leu Ile Gly Leu Val Arg Leu Ala Asp Pro Pro Ala 
    50                  55                  60                  


His Pro Asp Asp Trp Glu Asp Arg Gln Ala Pro Asp Ala Asp Arg Leu 
65                  70                  75                  80  


Arg Asp Arg Leu Ala Pro Phe Ala Pro Ala Phe Asn Leu Leu Gly Asp 
                85                  90                  95      


Gly Pro Arg Phe Met Gln Glu Met Gly Gly Leu Val Gly Asp Val Arg 
            100                 105                 110         


Ala Thr Asp Val Leu Phe Ile Asp Ser Gly Gly Asp Gly Gly Ala Leu 
        115                 120                 125             


Thr Val Arg Glu Gly Arg Tyr Pro Asn Leu Asp Leu Pro Thr Ala Ala 
    130                 135                 140                 


Met Ala Leu Tyr Ala Met Gln Thr Gln Ala Pro Ser Gly Gly Arg Gly 
145                 150                 155                 160 


Asn Leu Thr Ser Leu Arg Gly Gly Gly Pro Met Thr Val Leu Val Asp 
                165                 170                 175     


Pro Gly Gly Gly Met Trp Pro Leu Ile Trp Ala Asn Val Pro Asp Gly 
            180                 185                 190         


Lys Pro Val Val Pro Asn Val Leu Pro Trp Met Arg Arg Thr Val Thr 
        195                 200                 205             


Ser Glu Thr Gly Val Arg Phe Phe Pro His Gln Gly Asp Ala Ala Glu 
    210                 215                 220                 


Val Phe Phe Gly Met Pro Arg Arg Leu Trp Leu Glu Ala Arg Asn Asp 
225                 230                 235                 240 


Ser Val Thr Gly Val Ile Gln Arg Pro Ser Gly Thr Lys Tyr Val Gly 
                245                 250                 255     


Trp Arg His Pro Leu Thr Pro Tyr Tyr Arg Gln Lys Ala Gly Asp Thr 
            260                 265                 270         


Pro Leu Pro Val Arg Pro Arg Ala Gly Val Phe Gly Tyr Arg His Trp 
        275                 280                 285             


Leu Gly Ile Ala Ala Glu Gln Gly Ser Asp Leu Arg Glu Arg Pro Ala 
    290                 295                 300                 


Thr Val Glu Ala Trp Glu Ser Arg Gly Leu Gly Arg Arg Ala Asp Ile 
305                 310                 315                 320 


Ile Val Ala Gly Trp Ala Met Glu Asn Met Lys Ala Arg Asp Tyr Ile 
                325                 330                 335     


Trp Ser Arg Ala Pro Leu Val Thr Leu Pro Glu Glu Arg Ala Ala Phe 
            340                 345                 350         


Leu Arg Asp Met Ile Glu Ala Ala Asp Leu Leu Ser Ala Ala Leu Arg 
        355                 360                 365             


Gly Ala Leu Ala Thr Leu Leu Gly Glu Gly Glu Gly Arg Glu Ala Ala 
    370                 375                 380                 


Arg Glu Ala Phe Tyr Val Arg Thr Gln Ala Ala Phe Glu Gly Trp Val 
385                 390                 395                 400 


Ser Cys Leu Asp Thr Ile Ala Leu Asp Ala Ala Ala Arg Gly Trp Leu 
                405                 410                 415     


Ala Asp Met Arg Lys Val Ala Leu Glu Ile Phe Glu Val Leu Ala Leu 
            420                 425                 430         


Pro Gly Leu Ala Asp Arg Thr Ile Leu Val Gln Gln Glu Ile Val Ala 
        435                 440                 445             


Ala His Arg Gly Leu Thr Gly Ser Phe Ser Gly Tyr Gly Lys Leu Gly 
    450                 455                 460                 


Thr Lys Ala Phe Gly Val Leu Asn Leu Pro Val Pro Thr Arg Lys Lys 
465                 470                 475                 480 


Glu Ala Ala Thr 
                


<210>  33
<211>  174
<212>  PRT
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(174)
<223>  Cse2

<400>  33

Met Ser Asp Arg Lys Gln Val Ile Gly Thr Trp Trp Arg Thr Arg Ile 
1               5                   10                  15      


Gly Ala Arg Asn Ser Thr Ala Ala Arg Ala Leu Ala Ala Arg Leu Asn 
            20                  25                  30          


Arg Gly Glu Gly Val Asp Val Leu Ala Glu Arg Ala Val Phe Glu Leu 
        35                  40                  45              


Gly Arg Asp Leu Gly Phe Leu Lys Gln Pro Lys Arg Leu Val Leu Leu 
    50                  55                  60                  


Val Arg Val Leu Ala Ala Val Arg Glu Asp Arg Gly Gly Ala Leu Pro 
65                  70                  75                  80  


Leu Arg Leu Gly Gln Gly Asp Pro Pro Pro Leu Ser Pro Leu Arg Phe 
                85                  90                  95      


Gln Arg Leu Leu Arg Ala Glu Gly Glu Glu Leu Thr Thr Leu Leu Arg 
            100                 105                 110         


Arg Ala Leu Pro Met Val Thr Arg Thr Cys Asp Val Gly Ala Leu Gly 
        115                 120                 125             


Ala Asp Leu Leu Asp Trp Ser Asp Ser Thr Arg Ala Arg Trp Ala Phe 
    130                 135                 140                 


Ala Tyr Phe Gly Ala Thr Pro Pro Ala Arg Ile Asn Asn Ser Arg Pro 
145                 150                 155                 160 


Thr Pro Glu Thr Pro Ala Leu Ser Asp Gln Glu Thr Glu Glu 
                165                 170                 


<210>  34
<211>  360
<212>  PRT
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(360)
<223>  Cas7

<400>  34

Met Thr Thr Phe Leu Gln Phe His Val Leu Thr Thr Tyr Pro Pro Ser 
1               5                   10                  15      


Asn Pro Asn Arg Asp Asp Gln Gly Arg Pro Lys Gln Ala Asn Leu Gly 
            20                  25                  30          


Gly Ala Pro Arg Leu Arg Leu Ser Ser Gln Ser Ile Lys Arg Ala Met 
        35                  40                  45              


Arg Glu Ser Pro Ala Phe Gln Gln Gly Leu Asp Gly His Ile Gly Thr 
    50                  55                  60                  


Arg Thr Lys Arg Leu Gly Glu Glu Ile Arg Glu Glu Leu Ala Lys Arg 
65                  70                  75                  80  


Glu Gly Val Ser Thr Asp Gln Ala Leu Asp Val Ala Ser Lys Val Ala 
                85                  90                  95      


Ala Ile Phe Ser Lys Leu Glu Ala Pro Gly Lys Asp Lys Val Gln Lys 
            100                 105                 110         


Pro Leu Thr Thr Thr Leu Ala Phe Val Ser Pro Asp Glu Trp Ala Leu 
        115                 120                 125             


Ala Arg Asp Leu Ala Ser Arg Met Leu Ala Gly Glu Glu Met Pro Lys 
    130                 135                 140                 


Asp Lys Glu Leu Lys Arg Leu Val Leu Arg Arg Ala Asp Gly Ala Val 
145                 150                 155                 160 


Asp Ile Ala Met Phe Gly Arg Met Leu Ala Asp Glu Pro Gly Tyr Asn 
                165                 170                 175     


Arg Glu Ala Ala Val Gln Val Ser His Ala Ile Thr Thr His Arg Ala 
            180                 185                 190         


Ile Ala Glu Asp Asp Trp Tyr Ser Ala Val Asp Asp Leu Asn Lys Arg 
        195                 200                 205             


Glu Asp Ser Gly Ala Gly His Leu Gly Glu His Gly Phe Gly Ser Gly 
    210                 215                 220                 


Val Tyr Tyr Leu Tyr Ala Cys Val Asn Val Asp Leu Leu Val Glu Asn 
225                 230                 235                 240 


Leu Ala Gly Asp Arg Ala Leu Ala Ala Arg Gly Leu Glu Ala Leu Ala 
                245                 250                 255     


Lys Ala Leu Ala Thr Ala Thr Pro Arg Gly Lys Gln Asn Ser His Ala 
            260                 265                 270         


His His Pro Arg Ala Ile Tyr Val Arg Ala Glu Arg Gly Pro Gln Gln 
        275                 280                 285             


Pro Arg Asp Leu Thr Gly Ala Phe Phe Ser Ala Val Asp Leu Lys Ser 
    290                 295                 300                 


Asn Asp Ile Glu Arg Thr Ser Ile Ile Ala Leu Glu Arg Thr Ala Glu 
305                 310                 315                 320 


Gln Ile Asp Arg Ala Tyr Gly Ala Ala Cys Asp Asp Thr Ala Val Met 
                325                 330                 335     


Asp Val Lys Glu Gly Asn Gly Thr Leu Ala Glu Ile Ala Ala Phe Ser 
            340                 345                 350         


Gly Ala Ser Val Ser Ala Asn Ala 
        355                 360 


<210>  35
<211>  254
<212>  PRT
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(254)
<223>  Cas5

<400>  35

Met Ala Leu Trp Pro Arg Ser Leu Pro Phe Leu Ala Arg Arg Tyr Leu 
1               5                   10                  15      


Pro Met Arg Glu His Leu Val Phe Thr Leu Ala Ala Ala Val Ala Ser 
            20                  25                  30          


Met Gly Glu Leu Ala Gly His Glu Arg Arg Gly Thr Trp Ser Trp Pro 
        35                  40                  45              


Gly Arg Ser Ser Val Leu Gly Leu Cys Ala Ala Ala Leu Gly Ile Arg 
    50                  55                  60                  


Arg Asp Gly Asp Phe Ser Ala Leu Asp Gly Leu Gly Leu Ala Val Ala 
65                  70                  75                  80  


Val Phe Asp Thr Gly Glu Pro Leu Arg Asp Phe His Thr Ala Val Ser 
                85                  90                  95      


Ile Pro Ser Ser Val Ala Lys Arg Pro Gln Ser Arg Ala Asp Ala Leu 
            100                 105                 110         


Arg Ile Asp Ala Gly Arg Ser Asn Ser Thr Ile Thr Leu Arg Asp Tyr 
        115                 120                 125             


Arg Val Gly Val Leu Tyr Gly Val Ala Leu Trp Gly Asp Gly Leu Pro 
    130                 135                 140                 


Thr Val Ala Glu Asn Leu Val Glu Ala Leu Gln Arg Pro Thr Phe Thr 
145                 150                 155                 160 


Leu Tyr Leu Gly Arg Lys Ser Cys Pro Leu Ala Ala Pro Leu Ala Pro 
                165                 170                 175     


Arg Val Leu Thr Ala Pro Asp Ala Ala Ala Ala Leu Thr Asp Gly Met 
            180                 185                 190         


Thr Leu Pro Pro Trp Arg Ala Gly Ala Arg Ala Gly Gln Ile Ala Thr 
        195                 200                 205             


Glu Glu Glu Leu Pro Ala Pro Arg Thr Glu Thr Arg His Asp Arg Pro 
    210                 215                 220                 


Thr Asp Arg Thr Ala Trp His Phe Ala Pro Arg Ala Val Arg Leu Val 
225                 230                 235                 240 


Pro Cys Asp Ile Ala Pro Arg Thr Ala Gly Gln Val Ala Ala 
                245                 250                 


<210>  36
<211>  235
<212>  PRT
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(235)
<223>  Cas6

<400>  36

Met Thr Leu Trp Leu Ser Arg Val Arg Ile Ala Arg Gly Ala Asp Leu 
1               5                   10                  15      


Asp Thr Leu Arg Pro Leu Leu Asp Pro Ser Ala Leu His Pro Ala Ala 
            20                  25                  30          


Met Asp Pro Lys Met Leu Gly Ser Gln Thr Asp Ala His His Arg Leu 
        35                  40                  45              


Ile Trp Thr Leu Phe Ala Asp Ser Arg Asp Arg Arg Arg Asp Phe Leu 
    50                  55                  60                  


Trp Arg Ala Glu Gly Ala Gly Lys Phe Thr Leu Leu Ser Leu Arg Pro 
65                  70                  75                  80  


Pro Thr Ala Ser Arg Val Phe Glu Ala Pro Glu Val Lys Ala Phe Ser 
                85                  90                  95      


Pro Asp Leu Leu Pro Gly Asp Arg Leu Ala Phe Ala Leu Arg Ala Asn 
            100                 105                 110         


Ala Thr Arg Asp Arg Ala Gly Ser Ala Lys Gly Arg Arg Val Asp Val 
        115                 120                 125             


Val Met His Ala Leu His Asn Val Pro Pro Glu Asp Arg Ala Ala Ala 
    130                 135                 140                 


Arg Met Thr Leu Ala Gln Asp Ala Ala Ser Asp Trp Leu Thr Gly Gln 
145                 150                 155                 160 


Gly Ala Arg Ala Gly Phe Val Pro Glu Glu Val Thr Ala Gly Asp Tyr 
                165                 170                 175     


Ser Val Ala Ala Leu Pro Ser His Thr Gly Arg Arg Lys Gly Gln Pro 
            180                 185                 190         


Gln Tyr Gly Ile Leu Asp Leu Thr Gly Val Leu Arg Val Thr Asp Pro 
        195                 200                 205             


Ala Ala Phe Leu Ala Arg Leu Gly Gln Gly Phe Gly Arg Ala Arg Gly 
    210                 215                 220                 


Phe Gly Cys Gly Leu Met Leu Ile Arg Arg Ala 
225                 230                 235 


<210>  37
<211>  90
<212>  DNA
<213>  Oceanicola sp. HL-35


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  37
ctgttccccg cacacgcggg gatgaaccgg gttcttcgat ctgcgcatcc atgatgccgc       60

cctgttcccc gcacacgcgg ggatgaaccg                                        90


<210>  38
<211>  1554
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(1554)
<223>  Cas8

<400>  38
atggatttgt taagtgatac ctggctgcag tgccgccatc gtgatggcac gctgaagccg       60

atagctattg ggcagatagg gctagaagac tgtttagagc tggttgcgcc acgccccgac      120

ttccgtggtg cgctctatca gtttctgatc gggttgctgc aaaccgccta cgcgccagag      180

gatcttcagg agtggcgtga tcgctatgcc aacccaccta ccgctgatga cctggcagag      240

gttttcgctc cttaccgcga cgccttccag ctggaaaact cagggcctac ctttatgcag      300

gacctgacct tgcccgatga cgtcaatcag ctgccggtgc tggagctgtt gattgatgcc      360

ggctcatcga gcaatcagta tttcaacaag ccggcggttg agcacggcat gtgcgagggc      420

tgctttaccc aggcgttgct caccatgcag ttgaacgcgc cctctggcgg acgaggcatt      480

cggacctcgc tgcgtggtgg cggtccgttg acgaccttgc tggtgccagc cgaacagaac      540

gcgacgcttt ggcaaaagct ctggctcaac gtcttgcctc ttgatgcact cgatcacccg      600

ccgatcaaga tgctcagtga cgtattgccc tggctggcac caacccgcac cagcgatgac      660

aaacagggcc aggatacacc gccggagtcg gtgcacccct tgcaggcgta ctggagcatg      720

ccgcggcgca ttcgcctgga tgcagccacc ttggatcagg gggattgcgc ggtatgcggt      780

gcccagaatg taaagcgtat ccgtcattac cgtacccgcc atggcggcac caactacacc      840

gggacatgga ctcacccgct gacaccctac agcctggact cgaaaggaga aaagccgccg      900

ctctcgatca aggggcgtca ggccgggcga ggttaccgtg actggctggg tctggtactt      960

ggtaatgaag atcaccagcc ggatgccgcg caggttgttc ggcacttcac cgccaaactg     1020

ggcaagccgt ccgtgcgctt gtggtgcttc ggtttcgata tgtcgaacat gaaagcgttg     1080

tgctggtacg acagtctgtt gccggtacac ggcgtggcac ctgacgttca gcggaagttt     1140

acccgcagcg tcaagcaggt gctggattcg gccaatgaca tggcctccgt tctgcacaaa     1200

caggtcaaag cggcctggtt tcgccgtccg ggcgatgccg gtcaggagcc tgccgtgacg     1260

caaagttttt ggcagggctc tgagacggcc ttttatcagg tgctggagca gctcagcaag     1320

ctcgattttg acagcgcggc cgagttggca gcgatctaca gagcctggtt gcaggccacg     1380

cgtcgtctgg tgctaagtct gtttgaccac tgggtgctga gcggtccgct ggaagatatg     1440

gacatgcaac gcgtggtcaa ggcccgggct gatctggcca aagagctgaa tactggcaag     1500

gcacaaaagc cgctgtggac aatcgttaat caacatctca aggagcaggc atga           1554


<210>  39
<211>  642
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(642)
<223>  Cse2

<400>  39
atgaagccga gaaagcccag attgaacgag gcccagcagc gctgggtgcg cgactggtgg       60

cgcgccttgc agccccgcgc cgagggtgat gaacccatac ccggcgagct gtctgtcatg      120

gggaggggtg agcgggcaca actgcgccgc tgcaccgatg ccgatgagct gcttacccag      180

tcagccaccc tgctgctggc gcaccgtttg gttgcactca atggtgagcg aggccctttg      240

cctgataatt ccttgagcta cgagcgcatg gcctgggtgg ccggggtgct ggctaacgtc      300

aaggacgacc tgcgtgacgg caagagtctg gctacgcacc ttgggcaggc tgctgatgcc      360

gagcgcccgc cgatgagcga actgcgtttc agggctatgc agcgcggcac ggcgatgcag      420

gagctattcc tgcattggcg tcgggcgttg caactggccg ggggcaagac tgatgtggca      480

cacctggcag atgacctgct gagctggcag atagagcagg gccagtctgc tgctcaggcg      540

agcaacgggg tcaaatttca ctgggcctat gactactatc tgagcgcccg ggaccgggca      600

gccgccaaag aacctgaatt caacaaggag atatccaaat ga                         642


<210>  40
<211>  1035
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(1035)
<223>  Cas7

<400>  40
atgactcgtt ttgtgcaatt gcacctgctg acgtcctacc cgcccgccaa ccttaaccgc       60

gatgatctgg gcaacccgaa aaccgcacgc ctaggcggtg ttgaacgtct gcgtgtgtcc      120

tcgcaaagtc tcaaacgcgc ttggcgtacc tcggagctgt ttcagcaaca gttggccggg      180

actatcggca cgcgcaccaa gcgccttggt atcgaggttt tcgaggcact gctgggtgct      240

ggtgtcactg agaagcaggc gcgtgagtgg gctggacaaa tcgccaaggt ttacggggct      300

gcgaaaaagg ataatccact ggaaatcgag cagctggtcc atatcgcgcc tgaagagcgt      360

gcttcgctgg atcaactggt ggccaccctt gccgcggaaa aacgcggccc aacggatgag      420

gagttggacg ccctgctgca ccaccagaca gcggtggata tcgccatgtt tggtcgcatg      480

ctggcctcca aaacacagtt caacggagag gccgcagtgc aggtagccca tgccatcggc      540

gtgcacgcat cggctattga ggatgactac ttcaccgccg ttgacgatct caaccgcaat      600

gatcctggcg ctgcgcatat cggtgaatcc ggtttcgccg ctgcagtgtt ctaccagtac      660

atctgcatcg accgcgatct gctgaaacgg aatctggggg gcgatgaagt gctgactcaa      720

aaggcactcc gggctctgac tgaagcggcg ctcaaagtgg ggcccagcgg caagcaaaac      780

agcttcgcca gccgggcttt cgcccacttt gcgctggccg agaaaggcac tgatcagccg      840

cgctctctgt cactggcctt cgtcaaaccg gtggccggca cagactatgc cggtgatgcc      900

gttgcggcct tgcaacaggt gcgcgacaac atggacaagg tctatggagt ctgcgctgaa      960

agccgctgcc agttcaatgt gctgacgggt gaagggtcag tggccgacct gcttgatttt     1020

gtcgccgcgg agtga                                                      1035


<210>  41
<211>  768
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(768)
<223>  Cas5

<400>  41
atgactgact atctactgct gcggctctat ggcccgctgg ccagctgggg cgagattgca       60

gtcggcgaat cgcgacactc ggcggtacaa ccgtcgcgtt ccgcgctgct tggtttgctg      120

ggtgcagcgc tgggtatcga gcggcacgat gatgccgctc agcaggcgct tgtggacggt      180

taccgctttg cgatcaagct ggaatgcata ggttcgccct tgcgtgacta tcacacggtt      240

caggtaggcg tgccgccgcg caagttccag tttcgctcac gtcgtcagga attggctgcc      300

gacaaagtcg atactattct gtcgacccgt gagtaccgct gtgacagcct cgcgttggtt      360

gctgtggaag ccttgcccgg tgcgccggtg gacttggcct ccctggccga agcgctgcgt      420

aagccgcgct tcgccttgta tctggggcgc aaatcctgcc cgcttgcttt gccgttgagt      480

ccaaaaattc ttgccgccag cagtgtgcgt gaggtgttcg acaatctgga attgccttcc      540

ttgctgggtt tgttggatcg ctatcagccc gagcaagcct ggccaagtcg acaggaccaa      600

caggcactac gtcccggtgt cgcgcgatac tattgggaag acgggatgac tgctggcatg      660

gcgccgagct ttgaggccca acgacatgat cagccactct cccgtcgccg ctggcagttt      720

gcaccgcgcc gcgaatgggt ggccttgaat gatggagggc agtcatga                   768


<210>  42
<211>  663
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(663)
<223>  Cas6

<400>  42
atgagccatt atttctcgct tgttagactg atcggcagtc cgcgtcacga tgcctggctg       60

cgtgacttgt cgcgccatgg tgaagcctac agggatcatg cgttgatctg gcgcctgttc      120

ccgggcgatg gcgctgcacg tgactttgtt ttccgccgcc ttgaggacga aaaaagtttc      180

tatgtggttt cagcacgacc accacaggcc gatgcggggt tattccatat ccagagcaaa      240

gcctattcgc ctgagttggc cgagggtgat tgggtgcgat tcgacctgcg tgccaatccc      300

accgtcagcg tgcgccggga aaatggtcgc tcacagcgtc atgatgtgct gatgcacgcc      360

aagcagcttg ccagcacaga aaaatcggca ctacctgagc ggctggaagc agcaggcagg      420

gaatggctga aagacagggc ggaacgctgg ggactggatt tgcgtactga cagtcttatg      480

caaaacggtt atcgccagca gcggttgaag cgcaagggta aacacatcgc tttttccacg      540

ttggactatc agggcattgc ccaggtgacg gaccctgaac aattgcgccg ggcactgctc      600

gacggggttg gacacagcaa gggctttggc tgcgggctgt tgctggtaaa acgtgtggac      660

tga                                                                    663


<210>  43
<211>  1554
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(1554)
<223>  Cas8

<400>  43
atggacctgc tgtctgatac atggctgcag tgcaggcaca gggacggcac cctgaagcct       60

atcgccatcg gccagatcgg cctggaggac tgtctggagc tggtggcacc tcggcccgac      120

ttccggggcg ccctgtacca gttcctgatc ggcctgctgc agacagccta tgccccagag      180

gacctgcagg agtggagaga tagatacgcc aaccctccaa ccgccgacga tctggccgag      240

gtgtttgccc cttataggga tgccttccag ctggagaact ccggcccaac attcatgcag      300

gacctgaccc tgccagacga tgtgaatcag ctgcccgtgc tggagctgct gatcgacgca      360

ggctcctcta gcaaccagta ctttaataag ccagcagtgg agcacggaat gtgcgagggc      420

tgtttcacac aggccctgct gaccatgcag ctgaatgcac catccggcgg aaggggcatc      480

agaacatctc tgaggggagg aggacctctg accacactgc tggtgccagc cgagcagaac      540

gccaccctgt ggcagaagct gtggctgaat gtgctgcccc tggacgccct ggatcaccca      600

cctatcaaga tgctgtctga tgtgctgcca tggctggcac caacccggac aagcgacgat      660

aagcagggcc aggacacacc acccgagtct gtgcacccac tgcaggccta ctggagcatg      720

cctaggcgga tcagactgga cgcagccacc ctggaccagg gcgattgcgc cgtgtgcgga      780

gcacagaacg tgaagcgcat ccggcactac agaacaaggc acggcggcac caattatacc      840

ggcacatgga cccaccccct gaccccttat tctctggata gcaagggcga gaagcctcca      900

ctgagcatca agggccggca ggcaggaagg ggatacaggg actggctggg actggtgctg      960

ggaaacgagg accaccagcc tgatgccgcc caggtggtga ggcacttcac agccaagctg     1020

ggcaagccat ccgtgcgcct gtggtgcttt ggcttcgaca tgagcaatat gaaggccctg     1080

tgctggtacg attccctgct gccagtgcac ggagtggccc ctgacgtgca gaggaagttt     1140

acccgcagcg tgaagcaggt gctggactct gccaacgata tggccagcgt gctgcacaag     1200

caggtgaagg ccgcctggtt cagaaggccc ggcgacgcag gacaggagcc tgcagtgaca     1260

cagtcttttt ggcagggcag cgagaccgcc ttctatcagg tgctggagca gctgtccaag     1320

ctggactttg attctgccgc agagctggca gcaatctaca gagcatggct gcaggcaacc     1380

cgccggctgg tgctgagcct gttcgatcac tgggtgctgt ccggccctct ggaggacatg     1440

gatatgcagc gggtggtgaa ggcaagagca gacctggcca aggagctgaa cacaggcaag     1500

gcccagaagc cactgtggac catcgtgaat cagcacctga aggagcaggc ctaa           1554


<210>  44
<211>  642
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(642)
<223>  Cse2

<400>  44
atgaagccaa ggaagcctcg gctgaatgag gcccagcaga gatgggtgag ggattggtgg       60

agggccctgc agccaagggc agagggcgac gagccaatcc ctggagagct gagcgtgatg      120

ggaaggggag agagggcaca gctgcggaga tgtaccgacg ccgatgagct gctgacacag      180

tccgccaccc tgctgctggc acacaggctg gtggccctga acggagagag aggaccactg      240

cccgataata gcctgtccta tgagaggatg gcatgggtgg caggcgtgct ggcaaacgtg      300

aaggacgatc tgagagatgg caagtccctg gccacccacc tgggacaggc agcagacgca      360

gagaggcctc caatgtctga gctgcgcttt cgggccatgc agagaggcac agccatgcag      420

gagctgttcc tgcactggag gcgcgccctg cagctggcag gaggcaagac cgacgtggca      480

cacctggcag acgatctgct gagctggcag atcgagcagg gacagtctgc cgcacaggcc      540

agcaatggcg tgaagtttca ctgggcctac gactactatc tgtctgccag agatagggcc      600

gccgccaagg agccagagtt caacaaggag atcagcaaat aa                         642


<210>  45
<211>  1035
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(1035)
<223>  Cas7

<400>  45
atgacacgct ttgtgcagct gcacctgctg acctcttatc cccctgccaa cctgaatagg       60

gacgatctgg gaaaccctaa gacagcaagg ctgggaggag tggagagact gagggtgagc      120

tcccagtctc tgaagcgcgc ctggcggaca agcgagctgt ttcagcagca gctggcagga      180

accatcggaa ccagaacaaa gaggctgggc atcgaggtgt tcgaggccct gctgggagca      240

ggagtgaccg agaagcaggc aagggagtgg gcaggacaga tcgcaaaggt gtacggagcc      300

gccaagaagg ataaccccct ggagatcgag cagctggtgc acatcgcccc tgaggagagg      360

gccagcctgg accagctggt ggccacactg gcagcagaga agagaggacc aaccgacgag      420

gagctggatg ccctgctgca ccaccagaca gccgtggaca tcgccatgtt tggcaggatg      480

ctggccagca agacccagtt caatggagag gcagcagtgc aggtggcaca cgcaatcgga      540

gtgcacgcct ccgccatcga ggacgattac ttcaccgccg tggacgatct gaaccgcaat      600

gatccaggag cagcacacat cggagagtcc ggctttgccg ccgccgtgtt ctaccagtat      660

atctgcatcg accgggatct gctgaagaga aacctgggcg gcgacgaggt gctgacacag      720

aaggccctgc gcgccctgac cgaggccgcc ctgaaggtcg gccccagcgg caagcagaat      780

tcctttgcct ctagggcctt tgcccacttc gccctggccg agaagggcac agatcagcca      840

cgctccctgt ctctggcctt cgtgaagcca gtggcaggaa ccgactacgc aggcgatgcc      900

gtggccgccc tgcagcaggt gagggacaac atggataagg tgtatggcgt gtgcgccgag      960

tcccgctgtc agtttaatgt gctgacagga gagggctctg tggcagacct gctggatttc     1020

gtggcagcag agtaa                                                      1035


<210>  46
<211>  768
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(768)
<223>  Cas5

<400>  46
atgaccgact acctgctgct gaggctgtat ggaccactgg catcctgggg agagatcgca       60

gtgggagagt ctaggcacag cgccgtgcag ccttctcgca gcgccctgct gggactgctg      120

ggagccgccc tgggcatcga gagacacgac gatgcagcac agcaggccct ggtggatgga      180

taccggttcg ccatcaagct ggagtgtatc ggctctcccc tgagagacta tcacaccgtg      240

caagtgggag tgccaccaag gaagttccag tttagaagcc ggagacagga gctggcagca      300

gacaaggtgg atacaatcct gtccaccaga gagtataggt gcgattctct ggccctggtg      360

gcagtggagg ccctgccagg agcacccgtg gacctggcca gcctggcaga ggccctgcgc      420

aagccaaggt ttgccctgta cctgggaagg aagagctgtc cactggccct gcctctgtcc      480

ccaaagatcc tggccgcctc tagcgtgcgc gaggtgttcg ataacctgga gctgccttct      540

ctgctgggcc tgctggacag gtaccagcct gagcaggcct ggccaagcag acaggatcag      600

caggccctga ggccaggagt ggcaaggtac tattgggagg acggaatgac agcaggaatg      660

gcaccttctt ttgaggccca gaggcacgat cagccactga gcaggcgccg gtggcagttc      720

gcaccaagaa gggagtgggt ggccctgaac gatggaggac agtcctaa                   768


<210>  47
<211>  663
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(663)
<223>  Cas6

<400>  47
atgtctcact acttcagcct ggtgaggctg atcggctccc ctaggcacga cgcctggctg       60

agggatctga gcagacacgg agaggcctac agggaccacg ccctgatctg gagactgttc      120

cctggcgacg gagcagcaag ggatttcgtg tttcgccggc tggaggatga gaagtccttt      180

tatgtggtgt ctgccaggcc acctcaggca gacgcaggac tgttccacat ccagtccaag      240

gcctactctc cagagctggc agagggcgac tgggtgaggt tcgatctgcg cgccaacccc      300

acagtgtctg tgagaaggga gaatggcaga agccagaggc acgatgtgct gatgcacgcc      360

aagcagctgg ccagcaccga gaagtccgcc ctgcccgagc ggctggaggc agcaggaaga      420

gagtggctga aggacagggc agagcggtgg ggcctggacc tgagaaccga ttccctgatg      480

cagaacggct acagacagca gaggctgaag cgcaagggca agcacatcgc cttttctaca      540

ctggactatc agggcatcgc ccaggtgacc gatcccgagc agctgcgccg ggccctgctg      600

gacggagtgg gacactccaa gggattcgga tgcggactgc tgctggtgaa gcgggtggat      660

taa                                                                    663


<210>  48
<211>  517
<212>  PRT
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(517)
<223>  Cas8

<400>  48

Met Asp Leu Leu Ser Asp Thr Trp Leu Gln Cys Arg His Arg Asp Gly 
1               5                   10                  15      


Thr Leu Lys Pro Ile Ala Ile Gly Gln Ile Gly Leu Glu Asp Cys Leu 
            20                  25                  30          


Glu Leu Val Ala Pro Arg Pro Asp Phe Arg Gly Ala Leu Tyr Gln Phe 
        35                  40                  45              


Leu Ile Gly Leu Leu Gln Thr Ala Tyr Ala Pro Glu Asp Leu Gln Glu 
    50                  55                  60                  


Trp Arg Asp Arg Tyr Ala Asn Pro Pro Thr Ala Asp Asp Leu Ala Glu 
65                  70                  75                  80  


Val Phe Ala Pro Tyr Arg Asp Ala Phe Gln Leu Glu Asn Ser Gly Pro 
                85                  90                  95      


Thr Phe Met Gln Asp Leu Thr Leu Pro Asp Asp Val Asn Gln Leu Pro 
            100                 105                 110         


Val Leu Glu Leu Leu Ile Asp Ala Gly Ser Ser Ser Asn Gln Tyr Phe 
        115                 120                 125             


Asn Lys Pro Ala Val Glu His Gly Met Cys Glu Gly Cys Phe Thr Gln 
    130                 135                 140                 


Ala Leu Leu Thr Met Gln Leu Asn Ala Pro Ser Gly Gly Arg Gly Ile 
145                 150                 155                 160 


Arg Thr Ser Leu Arg Gly Gly Gly Pro Leu Thr Thr Leu Leu Val Pro 
                165                 170                 175     


Ala Glu Gln Asn Ala Thr Leu Trp Gln Lys Leu Trp Leu Asn Val Leu 
            180                 185                 190         


Pro Leu Asp Ala Leu Asp His Pro Pro Ile Lys Met Leu Ser Asp Val 
        195                 200                 205             


Leu Pro Trp Leu Ala Pro Thr Arg Thr Ser Asp Asp Lys Gln Gly Gln 
    210                 215                 220                 


Asp Thr Pro Pro Glu Ser Val His Pro Leu Gln Ala Tyr Trp Ser Met 
225                 230                 235                 240 


Pro Arg Arg Ile Arg Leu Asp Ala Ala Thr Leu Asp Gln Gly Asp Cys 
                245                 250                 255     


Ala Val Cys Gly Ala Gln Asn Val Lys Arg Ile Arg His Tyr Arg Thr 
            260                 265                 270         


Arg His Gly Gly Thr Asn Tyr Thr Gly Thr Trp Thr His Pro Leu Thr 
        275                 280                 285             


Pro Tyr Ser Leu Asp Ser Lys Gly Glu Lys Pro Pro Leu Ser Ile Lys 
    290                 295                 300                 


Gly Arg Gln Ala Gly Arg Gly Tyr Arg Asp Trp Leu Gly Leu Val Leu 
305                 310                 315                 320 


Gly Asn Glu Asp His Gln Pro Asp Ala Ala Gln Val Val Arg His Phe 
                325                 330                 335     


Thr Ala Lys Leu Gly Lys Pro Ser Val Arg Leu Trp Cys Phe Gly Phe 
            340                 345                 350         


Asp Met Ser Asn Met Lys Ala Leu Cys Trp Tyr Asp Ser Leu Leu Pro 
        355                 360                 365             


Val His Gly Val Ala Pro Asp Val Gln Arg Lys Phe Thr Arg Ser Val 
    370                 375                 380                 


Lys Gln Val Leu Asp Ser Ala Asn Asp Met Ala Ser Val Leu His Lys 
385                 390                 395                 400 


Gln Val Lys Ala Ala Trp Phe Arg Arg Pro Gly Asp Ala Gly Gln Glu 
                405                 410                 415     


Pro Ala Val Thr Gln Ser Phe Trp Gln Gly Ser Glu Thr Ala Phe Tyr 
            420                 425                 430         


Gln Val Leu Glu Gln Leu Ser Lys Leu Asp Phe Asp Ser Ala Ala Glu 
        435                 440                 445             


Leu Ala Ala Ile Tyr Arg Ala Trp Leu Gln Ala Thr Arg Arg Leu Val 
    450                 455                 460                 


Leu Ser Leu Phe Asp His Trp Val Leu Ser Gly Pro Leu Glu Asp Met 
465                 470                 475                 480 


Asp Met Gln Arg Val Val Lys Ala Arg Ala Asp Leu Ala Lys Glu Leu 
                485                 490                 495     


Asn Thr Gly Lys Ala Gln Lys Pro Leu Trp Thr Ile Val Asn Gln His 
            500                 505                 510         


Leu Lys Glu Gln Ala 
        515         


<210>  49
<211>  213
<212>  PRT
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(213)
<223>  Cse2

<400>  49

Met Lys Pro Arg Lys Pro Arg Leu Asn Glu Ala Gln Gln Arg Trp Val 
1               5                   10                  15      


Arg Asp Trp Trp Arg Ala Leu Gln Pro Arg Ala Glu Gly Asp Glu Pro 
            20                  25                  30          


Ile Pro Gly Glu Leu Ser Val Met Gly Arg Gly Glu Arg Ala Gln Leu 
        35                  40                  45              


Arg Arg Cys Thr Asp Ala Asp Glu Leu Leu Thr Gln Ser Ala Thr Leu 
    50                  55                  60                  


Leu Leu Ala His Arg Leu Val Ala Leu Asn Gly Glu Arg Gly Pro Leu 
65                  70                  75                  80  


Pro Asp Asn Ser Leu Ser Tyr Glu Arg Met Ala Trp Val Ala Gly Val 
                85                  90                  95      


Leu Ala Asn Val Lys Asp Asp Leu Arg Asp Gly Lys Ser Leu Ala Thr 
            100                 105                 110         


His Leu Gly Gln Ala Ala Asp Ala Glu Arg Pro Pro Met Ser Glu Leu 
        115                 120                 125             


Arg Phe Arg Ala Met Gln Arg Gly Thr Ala Met Gln Glu Leu Phe Leu 
    130                 135                 140                 


His Trp Arg Arg Ala Leu Gln Leu Ala Gly Gly Lys Thr Asp Val Ala 
145                 150                 155                 160 


His Leu Ala Asp Asp Leu Leu Ser Trp Gln Ile Glu Gln Gly Gln Ser 
                165                 170                 175     


Ala Ala Gln Ala Ser Asn Gly Val Lys Phe His Trp Ala Tyr Asp Tyr 
            180                 185                 190         


Tyr Leu Ser Ala Arg Asp Arg Ala Ala Ala Lys Glu Pro Glu Phe Asn 
        195                 200                 205             


Lys Glu Ile Ser Lys 
    210             


<210>  50
<211>  344
<212>  PRT
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(344)
<223>  Cas7

<400>  50

Met Thr Arg Phe Val Gln Leu His Leu Leu Thr Ser Tyr Pro Pro Ala 
1               5                   10                  15      


Asn Leu Asn Arg Asp Asp Leu Gly Asn Pro Lys Thr Ala Arg Leu Gly 
            20                  25                  30          


Gly Val Glu Arg Leu Arg Val Ser Ser Gln Ser Leu Lys Arg Ala Trp 
        35                  40                  45              


Arg Thr Ser Glu Leu Phe Gln Gln Gln Leu Ala Gly Thr Ile Gly Thr 
    50                  55                  60                  


Arg Thr Lys Arg Leu Gly Ile Glu Val Phe Glu Ala Leu Leu Gly Ala 
65                  70                  75                  80  


Gly Val Thr Glu Lys Gln Ala Arg Glu Trp Ala Gly Gln Ile Ala Lys 
                85                  90                  95      


Val Tyr Gly Ala Ala Lys Lys Asp Asn Pro Leu Glu Ile Glu Gln Leu 
            100                 105                 110         


Val His Ile Ala Pro Glu Glu Arg Ala Ser Leu Asp Gln Leu Val Ala 
        115                 120                 125             


Thr Leu Ala Ala Glu Lys Arg Gly Pro Thr Asp Glu Glu Leu Asp Ala 
    130                 135                 140                 


Leu Leu His His Gln Thr Ala Val Asp Ile Ala Met Phe Gly Arg Met 
145                 150                 155                 160 


Leu Ala Ser Lys Thr Gln Phe Asn Gly Glu Ala Ala Val Gln Val Ala 
                165                 170                 175     


His Ala Ile Gly Val His Ala Ser Ala Ile Glu Asp Asp Tyr Phe Thr 
            180                 185                 190         


Ala Val Asp Asp Leu Asn Arg Asn Asp Pro Gly Ala Ala His Ile Gly 
        195                 200                 205             


Glu Ser Gly Phe Ala Ala Ala Val Phe Tyr Gln Tyr Ile Cys Ile Asp 
    210                 215                 220                 


Arg Asp Leu Leu Lys Arg Asn Leu Gly Gly Asp Glu Val Leu Thr Gln 
225                 230                 235                 240 


Lys Ala Leu Arg Ala Leu Thr Glu Ala Ala Leu Lys Val Gly Pro Ser 
                245                 250                 255     


Gly Lys Gln Asn Ser Phe Ala Ser Arg Ala Phe Ala His Phe Ala Leu 
            260                 265                 270         


Ala Glu Lys Gly Thr Asp Gln Pro Arg Ser Leu Ser Leu Ala Phe Val 
        275                 280                 285             


Lys Pro Val Ala Gly Thr Asp Tyr Ala Gly Asp Ala Val Ala Ala Leu 
    290                 295                 300                 


Gln Gln Val Arg Asp Asn Met Asp Lys Val Tyr Gly Val Cys Ala Glu 
305                 310                 315                 320 


Ser Arg Cys Gln Phe Asn Val Leu Thr Gly Glu Gly Ser Val Ala Asp 
                325                 330                 335     


Leu Leu Asp Phe Val Ala Ala Glu 
            340                 


<210>  51
<211>  255
<212>  PRT
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(255)
<223>  Cas5

<400>  51

Met Thr Asp Tyr Leu Leu Leu Arg Leu Tyr Gly Pro Leu Ala Ser Trp 
1               5                   10                  15      


Gly Glu Ile Ala Val Gly Glu Ser Arg His Ser Ala Val Gln Pro Ser 
            20                  25                  30          


Arg Ser Ala Leu Leu Gly Leu Leu Gly Ala Ala Leu Gly Ile Glu Arg 
        35                  40                  45              


His Asp Asp Ala Ala Gln Gln Ala Leu Val Asp Gly Tyr Arg Phe Ala 
    50                  55                  60                  


Ile Lys Leu Glu Cys Ile Gly Ser Pro Leu Arg Asp Tyr His Thr Val 
65                  70                  75                  80  


Gln Val Gly Val Pro Pro Arg Lys Phe Gln Phe Arg Ser Arg Arg Gln 
                85                  90                  95      


Glu Leu Ala Ala Asp Lys Val Asp Thr Ile Leu Ser Thr Arg Glu Tyr 
            100                 105                 110         


Arg Cys Asp Ser Leu Ala Leu Val Ala Val Glu Ala Leu Pro Gly Ala 
        115                 120                 125             


Pro Val Asp Leu Ala Ser Leu Ala Glu Ala Leu Arg Lys Pro Arg Phe 
    130                 135                 140                 


Ala Leu Tyr Leu Gly Arg Lys Ser Cys Pro Leu Ala Leu Pro Leu Ser 
145                 150                 155                 160 


Pro Lys Ile Leu Ala Ala Ser Ser Val Arg Glu Val Phe Asp Asn Leu 
                165                 170                 175     


Glu Leu Pro Ser Leu Leu Gly Leu Leu Asp Arg Tyr Gln Pro Glu Gln 
            180                 185                 190         


Ala Trp Pro Ser Arg Gln Asp Gln Gln Ala Leu Arg Pro Gly Val Ala 
        195                 200                 205             


Arg Tyr Tyr Trp Glu Asp Gly Met Thr Ala Gly Met Ala Pro Ser Phe 
    210                 215                 220                 


Glu Ala Gln Arg His Asp Gln Pro Leu Ser Arg Arg Arg Trp Gln Phe 
225                 230                 235                 240 


Ala Pro Arg Arg Glu Trp Val Ala Leu Asn Asp Gly Gly Gln Ser 
                245                 250                 255 


<210>  52
<211>  220
<212>  PRT
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(220)
<223>  Cas6

<400>  52

Met Ser His Tyr Phe Ser Leu Val Arg Leu Ile Gly Ser Pro Arg His 
1               5                   10                  15      


Asp Ala Trp Leu Arg Asp Leu Ser Arg His Gly Glu Ala Tyr Arg Asp 
            20                  25                  30          


His Ala Leu Ile Trp Arg Leu Phe Pro Gly Asp Gly Ala Ala Arg Asp 
        35                  40                  45              


Phe Val Phe Arg Arg Leu Glu Asp Glu Lys Ser Phe Tyr Val Val Ser 
    50                  55                  60                  


Ala Arg Pro Pro Gln Ala Asp Ala Gly Leu Phe His Ile Gln Ser Lys 
65                  70                  75                  80  


Ala Tyr Ser Pro Glu Leu Ala Glu Gly Asp Trp Val Arg Phe Asp Leu 
                85                  90                  95      


Arg Ala Asn Pro Thr Val Ser Val Arg Arg Glu Asn Gly Arg Ser Gln 
            100                 105                 110         


Arg His Asp Val Leu Met His Ala Lys Gln Leu Ala Ser Thr Glu Lys 
        115                 120                 125             


Ser Ala Leu Pro Glu Arg Leu Glu Ala Ala Gly Arg Glu Trp Leu Lys 
    130                 135                 140                 


Asp Arg Ala Glu Arg Trp Gly Leu Asp Leu Arg Thr Asp Ser Leu Met 
145                 150                 155                 160 


Gln Asn Gly Tyr Arg Gln Gln Arg Leu Lys Arg Lys Gly Lys His Ile 
                165                 170                 175     


Ala Phe Ser Thr Leu Asp Tyr Gln Gly Ile Ala Gln Val Thr Asp Pro 
            180                 185                 190         


Glu Gln Leu Arg Arg Ala Leu Leu Asp Gly Val Gly His Ser Lys Gly 
        195                 200                 205             


Phe Gly Cys Gly Leu Leu Leu Val Lys Arg Val Asp 
    210                 215                 220 


<210>  53
<211>  90
<212>  DNA
<213>  Pseudomonas sp. S-6-2


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  53
gtgttccccg cacctgcggg gatgaaccgg gccggggcgt ttgcgctgtc aggggcgtcc       60

cgtgttcccc gcacctgcgg ggatgaaccg                                        90


<210>  54
<211>  1536
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(1536)
<223>  Cas8

<400>  54
atggatttaa ccaaagagaa atggcttccc gtcatattct caaacggcga aaaaacgaga       60

atatcattac gcgatcttct ggataaccgc attcaggatc ttgcataccc ccggcccgat      120

tttcaggggg ctgcatggca aatgctgatt ggtattttac aatgtaccgt cgcgccggaa      180

gataaagaag aatgggcaga tatctggcat gaaagtatcg aattcgaaca atgggagaag      240

gcgttaaata cgatttctct ggctctacag ttcggcgagc aaaaaccttc cttcctgcaa      300

agttttgatc ctctcgatag tgaatatggt tctattgccg ggctgctggt ggatgcgccg      360

ggcggtaatg cgctcaagct caataaagat cattttgtaa aacgtggcaa cgtagaacaa      420

atatgtcctc actgcgcggc gatagcgcta tttgcgattc aaaccaattc acctgccggc      480

ggggcgggtt accgggtagg gatgcgcggc ggtggtccgc tgactacgct ggtggtaccg      540

caggaagaag ataaatatcc actatggaaa aaactttggc ttaacgtttt gccgcaggaa      600

gagccgccga atgttacaca gcatccactc atttttccct ggcttgcgcc gacgaaaacc      660

agcgaaaaag cggggaatgt ggtcacaccg gataatgcgc accccttgca agcctactgg      720

ggaatgccgc ggcgcataga actggatttc acccacactg tggcaggtat ctgcgatttg      780

tgcggggagc atcacgaatc actgctactg caaatgcgta gtaaaaatta tggcgttcag      840

tacgacagtt ggttacatcc tttctcccca tatcggcagg cattgaaaga tccatccgca      900

ccctggctgg cgtttaaagg gcagccgggc gggttaagtt ataaagactg gttggggctg      960

atgctcaatc gtgaggataa gttcaacaaa atgcagcctg caaaggtcgt tcgtgccgct     1020

ggtcagcgga acaaaatgag cctgtggtgc tttgcctggg atatggataa ggccaaggtc     1080

cgctgctggt atcagcaccg tattccgctc attagcgttt cgcacgaaga gcaatttctc     1140

gctgtgctta acattgtgct ggtgctggct agtgagtcgc tgtcgctgtt acggaacgcg     1200

ttaaagagcg ccaaattcga ttgtccgaaa gaagccaaaa tggattttag tatggtggat     1260

atcgccttct ggcaggaaac cgaacccgct tttcggacgt tgcaagaggc gctggctgtc     1320

gatccgcttc ggcaggatac acagactcgt cacgcagtaa gtcagtggga ggcggaatta     1380

gcacactatc tatttcacgt ttttgatcgt gatgccctga ccaaccccga ctgcccggac     1440

gatatcctgc agcgccagct gacggcccga caggatttag ccagcagcta tcgtaaacat     1500

aaagcgcgca aggatgtgtt ggcgctggtc gaataa                               1536


<210>  55
<211>  603
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(603)
<223>  Cse2

<400>  55
atgctgaata gcaatacagc agtgttatgc agaattctcc accccgatgc gcagaaggcg       60

ctacttgact ggtttgctac gctgtctgag cgttacgagc gcaaggatgg taaacgagtc      120

aacggtcgcg cctggcgggc tgagttgaaa agaatggcgc cgccatatgg cgtaatgata      180

tgtgaagggc atgacgctct ccgccaggcg ctgcttaaac atatgcgact gcaacctctt      240

gatgagatgg ctctggcgct gtttgtcagc gtcgctgtgc atattaagag ccataaggcg      300

aatattagtt tcgctgcaca attaggggaa aagcttaaag gttctacgcc gtgcgtttct      360

gttctgcgtt ttgaacgttt gcaaaaagcg tccgacccgg aaacattttg ccagttgttg      420

attcaggcag tgaagattcg cggtacggag ggggtgaatg ttctttcact tgccgatggc      480

attttcctgt ggatggaaga gtggcaacga cgcgaaaacc atcagccgga attccgtaac      540

ccctttgaac gaaatcgcat ccgttgggcg aacgaatatc tttccacgtc gcgtggcaaa      600

taa                                                                    603


<210>  56
<211>  1065
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(1065)
<223>  Cas7

<400>  56
ttgataatga caacttttat tcaactgcat ttattgactg cttatgcgcc cgctaacctg       60

aatcgtgatg agtctggcag accgaagacc gcgtttatgg gaggagttga gcgtttacgc      120

gtatcgtcgc aaagtctgaa gcgtgcctgg cgggtgtcgg aaacttttga agcggcaatg      180

gatggtttta tgggtaagcg tactcgtcga attggcgtgg attatgttta tcgtccgatg      240

aaagatgccg gaattgaaga aaaaattgct aagagttcgt ctgagttaat cgctaagcaa      300

tttggcaagc ttaaaagtga taaagatgcg aaaccggaaa aaaatctcga aattgagcag      360

atcgttcacg tcagtaacca tgaaattagt ttgattaagc aactggttga tacgctaatt      420

gccgacaaac gcgaacctaa cgatgaagaa gtggagttgt tgcgcaaaga gcagcgtagc      480

gtagatatgg cgctgtttgg ccgtatgctg gcgtcatcgc ctgagttcaa cgtcgaggct      540

gcttgtcagg tatcccatgc gttgggcgta agtgccgtga ccgttgagtc tgattttttc      600

accgccgttg acgatctgaa taataaagag gaagacgcag gttccgggca tatgggcgag      660

cagggttttg cctcggcgct tttctatacc tatgtctgta tcagccgcga tctgctggtg      720

gaaaacctgg gtggtaacga agaactggcg aagcgtacta tcgcggcact cactgaaaca      780

gcgttaaccg tctcgccaac cggtaaacaa aacagcttcg cttctcgtgc ctatgccacc      840

tatgcgttgg ccgaagtcgg gcaaaaacaa ccgcgttctc tggcggcggc atttttccag      900

ccggtacgcg ataccgatca aattccggcg gcaataaccc gtttaaaaca gcagcgcgcc      960

agcttcgata acgtatacgg aaactgtgca gacgattatc gcgagttgaa cgttcaggaa     1020

ggtacgggat ctctggcgga attactggcc tttgttagcc agtaa                     1065


<210>  57
<211>  726
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(726)
<223>  Cas5

<400>  57
atgaaggaat atctggtttt tcagctctat gcgccgctgg cgtcgtgggg ggaagaagcg       60

tctggcgaga ttcgccactc agctacggtt cccacgcgct ctgcgctatt gggtctgctt      120

gccgcagcgt taggaattcg tcgcgacgaa gaagcgcggc tgaataactt taaccggcac      180

tatcatctgg cggtgcacgc gttggcttca caagatcgct ggttgcggga ttatcacacg      240

gttagcgcgc cgcgagaaaa caaaaagaat cgttattaca cgcgccggga tgaactgact      300

ctcgcgccgg atgaagtggg gacgcttatc tcgcagcgag aatatcgctg cgacggctac      360

tggcatgtgg caataagcgc cacgcctgat gcaccacatt cgcttagcga attgcgagag      420

gcgctgctga caccgcattt tccgctctat ctggggagaa aatcctgccc gctggcgtta      480

ccgttagcgg cgcgtttaat gaccggcacc ttaaaagagg tattcaccca tgctgtggag      540

gagatttccg cagcggaatt aagtggattt accctgcgtg agggtatttg ttattgggat      600

gatcctgatg aggagagtct ggtctggcaa caaaagcagc atagcaataa ccagccagtt      660

agccgccaac gctggcagtt tggcggctac acccgcttca atgggccgtt gcaggagaga      720

acataa                                                                 726


<210>  58
<211>  705
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(705)
<223>  Cas6

<400>  58
atgtatcttt ctcgtattca actccggttt aataatttgc gaccggagat gttggcaaag       60

tggaattcag ccaggcctta tgccagccac cagtggttat ggcagctctt tccggaacag      120

gaattgcgtc agtttctgtt tcgcgaagag gcgcatggcg gcttttttat gctctcggca      180

ataccgccgt tatcgcagca ctccctgttt cttattgaaa ccaaaccatt taatccgcaa      240

ctgacaaatg gtcttgagct tgattttcaa ctacgagcta acccggtgat aacccgtaac      300

ggtaagcgca gtgacgtgat gatgaacgcg aaacatcagg cgaaggcgaa tggtgtggag      360

aaagaacggt ggtgggagct tcaacagcag gccgcgcagg cgtggctgga acaacaaggg      420

cagcagcatg gtttccggtt gattgcaccg gaacctgatg atttcgctat gtgggctggt      480

gacgagtaca gtgaattgca ggcacattgt ggatgcgtgc aagcgtatca gcagcatcgt      540

tttgtccgta aagaccagca aaaaccgatc actttcagta gcgttgattt tagcggtgcg      600

ctctgtatca ccgatgcagc actgtttaaa caggctttat tttccggatt aggtaaaagt      660

aaagcgctgg gctgcggaat gctgatggta aaaaggaaac gctga                      705


<210>  59
<211>  1536
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(1536)
<223>  Cas8

<400>  59
atggacctga ccaaagagaa gtggctgcct gtgatctttt ctaacggcga gaagacaaga       60

atcagcctga gggacctgct ggataatcgc atccaggacc tggcctatcc tcggccagat      120

ttccagggag cagcatggca gatgctgatc ggcatcctgc agtgtaccgt ggccccagag      180

gacaaggagg agtgggccga tatctggcac gagtctatcg agtttgagca gtgggagaag      240

gccctgaaca caatcagcct ggccctgcag ttcggcgagc agaagccctc ttttctgcag      300

agcttcgacc ctctggattc cgagtacggc tctatcgcag gactgctggt ggacgcacca      360

ggaggcaacg ccctgaagct gaataaggat cactttgtga agagaggcaa cgtggagcag      420

atctgcccac actgtgcagc aatcgccctg ttcgccatcc agaccaatag ccctgcagga      480

ggagcaggct atagggtggg aatgagggga ggaggaccac tgaccacact ggtggtgcct      540

caggaggagg acaagtaccc actgtggaag aagctgtggc tgaacgtgct gccacaggag      600

gagcccccta atgtgaccca gcacccactg atctttccct ggctggcccc taccaagaca      660

tccgagaagg ccggcaacgt ggtgacacct gataatgccc acccactgca ggcctactgg      720

ggaatgccaa ggaggatcga gctggacttc acccacacag tggcaggaat ctgcgacctg      780

tgcggagagc accacgagtc cctgctgctg cagatgcgct ctaagaacta cggcgtgcag      840

tatgactctt ggctgcaccc ctttagccct tataggcagg ccctgaagga cccctccgcc      900

ccatggctgg ccttcaaggg acagccagga ggactgtctt acaaggactg gctgggcctg      960

atgctgaaca gggaggataa gtttaataag atgcagccag caaaggtggt gcgcgcagca     1020

ggccagcgga ataagatgag cctgtggtgc ttcgcctggg acatggataa ggccaaggtg     1080

cgctgttggt accagcacag aatccccctg atctccgtgt ctcacgagga gcagttcctg     1140

gccgtgctga acatcgtgct ggtgctggcc agcgagtccc tgtctctgct gcggaatgcc     1200

ctgaagagcg ccaagtttga ctgccctaag gaggccaaga tggacttttc catggtggat     1260

atcgccttct ggcaggagac cgagcctgcc ttcagaacac tgcaggaggc cctggcagtg     1320

gacccactga gacaggatac ccagacaagg cacgccgtga gccagtggga ggcagagctg     1380

gcccactatc tgtttcacgt gttcgaccgc gatgccctga ccaaccctga ttgtccagac     1440

gatatcctgc agagacagct gacagcaagg caggacctgg caagctccta caggaagcac     1500

aaggcccgga aggatgtgct ggccctggtg gagtaa                               1536


<210>  60
<211>  603
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(603)
<223>  Cse2

<400>  60
atgctgaaca gcaataccgc cgtgctgtgc agaatcctgc accctgacgc ccagaaggcc       60

ctgctggatt ggttcgccac actgagcgag cggtacgagc ggaaggacgg caagcgcgtg      120

aacggaagag catggagggc agagctgaag aggatggcac caccctacgg cgtgatgatc      180

tgtgagggac acgacgccct gagacaggcc ctgctgaagc acatgaggct gcagcctctg      240

gatgagatgg cactggccct gttcgtgagc gtggcagtgc acatcaagtc tcacaaggcc      300

aacatcagct tcgccgcaca gctgggagag aagctgaagg gctccacccc atgcgtgtct      360

gtgctgcgct ttgagcggct gcagaaggcc agcgaccccg agaccttctg tcagctgctg      420

atccaggccg tgaagatcag gggcacagag ggcgtgaatg tgctgtccct ggccgatggc      480

atcttcctgt ggatggagga gtggcagagg cgcgagaacc accagccaga gtttcgcaac      540

cccttcgaga ggaatcgcat ccggtgggcc aatgagtacc tgtctaccag ccgcggcaag      600

taa                                                                    603


<210>  61
<211>  1065
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(1065)
<223>  Cas7

<400>  61
atgatcatga ccaccttcat ccagctgcac ctgctgaccg catacgcacc tgccaacctg       60

aatagagacg agagcggcag gccaaagaca gccttcatgg gaggagtgga gcggctgaga      120

gtgagctccc agagcctgaa gagagcctgg agggtgtccg agacctttga ggccgccatg      180

gatggcttca tgggcaagag aacacggaga atcggcgtgg actacgtgta taggcctatg      240

aaggatgccg gcatcgagga gaagatcgcc aagtctagct ccgagctgat cgccaagcag      300

ttcggcaagc tgaagagcga caaggatgcc aagccagaga agaacctgga gatcgagcag      360

atcgtgcacg tgagcaatca cgagatctcc ctgatcaagc agctggtgga caccctgatc      420

gccgataaga gggagccaaa cgacgaggag gtggagctgc tgcgcaagga gcagcggtcc      480

gtggatatgg ccctgtttgg ccgcatgctg gcctctagcc ccgagttcaa tgtggaggca      540

gcatgccagg tgtctcacgc cctgggcgtg agcgccgtga ccgtggagtc cgacttcttt      600

acagccgtgg acgatctgaa caataaggag gaggatgcag gctccggcca catgggagag      660

cagggatttg cctctgccct gttctacacc tacgtgtgca tcagccgcga cctgctggtg      720

gagaacctgg gaggcaatga ggagctggcc aagcggacaa tcgccgccct gaccgagaca      780

gccctgaccg tgagccctac aggcaagcag aacagctttg cctcccgcgc atacgcaacc      840

tatgccctgg cagaagtggg acagaagcag ccacgctccc tggcagcagc cttctttcag      900

cccgtgcggg acaccgatca gatccctgcc gccatcacac gcctgaagca gcagcgggcc      960

tcttttgaca acgtgtacgg caattgcgcc gacgattata gggagctgaa cgtgcaggag     1020

ggaaccggct ccctggcaga gctgctggcc ttcgtgtctc agtaa                     1065


<210>  62
<211>  726
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(726)
<223>  Cas5

<400>  62
atgaaggagt acctggtgtt tcagctgtat gcacctctgg caagctgggg agaggaggcc       60

tccggcgaga tcagacactc tgccaccgtg ccaacaaggt ccgccctgct gggactgctg      120

gcagccgccc tgggcatccg gcgggatgag gaggccagac tgaacaattt caataggcac      180

taccacctgg cagtgcacgc cctggcatcc caggacagat ggctgaggga ttatcacacc      240

gtgtctgccc cccgcgagaa caagaagaat cggtactata ccaggaggga cgagctgaca      300

ctggcccctg atgaagtggg cacactgatc tctcagcgcg agtaccggtg cgacggctat      360

tggcacgtgg caatcagcgc cacccccgat gcacctcact ccctgtctga gctgcgggag      420

gccctgctga caccacactt ccccctgtac ctgggcagaa agagctgtcc actggccctg      480

cctctggcag caaggctgat gaccggcaca ctgaaggagg tgtttaccca cgcagtggag      540

gagatcagcg ccgcagagct gtccggcttc acactgagag agggcatctg ctattgggac      600

gatcctgacg aggagtccct ggtgtggcag cagaagcagc acagcaacaa tcagccagtg      660

tccagacaga ggtggcagtt tggcggctac accaggttca acggaccact gcaggagagg      720

acataa                                                                 726


<210>  63
<211>  705
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(705)
<223>  Cas6

<400>  63
atgtatctga gcagaatcca gctgaggttt aacaatctga gacccgagat gctggccaag       60

tggaactccg ccaggcctta cgcctctcac cagtggctgt ggcagctgtt ccctgagcag      120

gagctgagac agttcctgtt tagggaggag gcccacggcg gcttctttat gctgagcgcc      180

atcccacccc tgtcccagca ctctctgttt ctgatcgaga ccaagccttt caacccacag      240

ctgacaaatg gcctggagct ggactttcag ctgagagcca accccgtgat cacccgcaat      300

ggcaagcggt ccgatgtgat gatgaacgcc aagcaccagg ccaaggccaa tggcgtggag      360

aaggagcggt ggtgggagct gcagcagcag gcagcacagg cctggctgga gcagcagggc      420

cagcagcacg gctttagact gatcgcccca gagcccgacg atttcgccat gtgggcaggc      480

gacgagtaca gcgagctgca ggcacactgc ggatgcgtgc aggcctatca gcagcacaga      540

ttcgtgagga aggatcagca gaagccaatc accttttcct ctgtggactt ctccggcgcc      600

ctgtgcatca cagatgccgc cctgtttaag caggccctgt tctccggcct gggcaagtct      660

aaggccctgg gctgcggcat gctgatggtg aagaggaaga gataa                      705


<210>  64
<211>  511
<212>  PRT
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(511)
<223>  Cas8

<400>  64

Met Asp Leu Thr Lys Glu Lys Trp Leu Pro Val Ile Phe Ser Asn Gly 
1               5                   10                  15      


Glu Lys Thr Arg Ile Ser Leu Arg Asp Leu Leu Asp Asn Arg Ile Gln 
            20                  25                  30          


Asp Leu Ala Tyr Pro Arg Pro Asp Phe Gln Gly Ala Ala Trp Gln Met 
        35                  40                  45              


Leu Ile Gly Ile Leu Gln Cys Thr Val Ala Pro Glu Asp Lys Glu Glu 
    50                  55                  60                  


Trp Ala Asp Ile Trp His Glu Ser Ile Glu Phe Glu Gln Trp Glu Lys 
65                  70                  75                  80  


Ala Leu Asn Thr Ile Ser Leu Ala Leu Gln Phe Gly Glu Gln Lys Pro 
                85                  90                  95      


Ser Phe Leu Gln Ser Phe Asp Pro Leu Asp Ser Glu Tyr Gly Ser Ile 
            100                 105                 110         


Ala Gly Leu Leu Val Asp Ala Pro Gly Gly Asn Ala Leu Lys Leu Asn 
        115                 120                 125             


Lys Asp His Phe Val Lys Arg Gly Asn Val Glu Gln Ile Cys Pro His 
    130                 135                 140                 


Cys Ala Ala Ile Ala Leu Phe Ala Ile Gln Thr Asn Ser Pro Ala Gly 
145                 150                 155                 160 


Gly Ala Gly Tyr Arg Val Gly Met Arg Gly Gly Gly Pro Leu Thr Thr 
                165                 170                 175     


Leu Val Val Pro Gln Glu Glu Asp Lys Tyr Pro Leu Trp Lys Lys Leu 
            180                 185                 190         


Trp Leu Asn Val Leu Pro Gln Glu Glu Pro Pro Asn Val Thr Gln His 
        195                 200                 205             


Pro Leu Ile Phe Pro Trp Leu Ala Pro Thr Lys Thr Ser Glu Lys Ala 
    210                 215                 220                 


Gly Asn Val Val Thr Pro Asp Asn Ala His Pro Leu Gln Ala Tyr Trp 
225                 230                 235                 240 


Gly Met Pro Arg Arg Ile Glu Leu Asp Phe Thr His Thr Val Ala Gly 
                245                 250                 255     


Ile Cys Asp Leu Cys Gly Glu His His Glu Ser Leu Leu Leu Gln Met 
            260                 265                 270         


Arg Ser Lys Asn Tyr Gly Val Gln Tyr Asp Ser Trp Leu His Pro Phe 
        275                 280                 285             


Ser Pro Tyr Arg Gln Ala Leu Lys Asp Pro Ser Ala Pro Trp Leu Ala 
    290                 295                 300                 


Phe Lys Gly Gln Pro Gly Gly Leu Ser Tyr Lys Asp Trp Leu Gly Leu 
305                 310                 315                 320 


Met Leu Asn Arg Glu Asp Lys Phe Asn Lys Met Gln Pro Ala Lys Val 
                325                 330                 335     


Val Arg Ala Ala Gly Gln Arg Asn Lys Met Ser Leu Trp Cys Phe Ala 
            340                 345                 350         


Trp Asp Met Asp Lys Ala Lys Val Arg Cys Trp Tyr Gln His Arg Ile 
        355                 360                 365             


Pro Leu Ile Ser Val Ser His Glu Glu Gln Phe Leu Ala Val Leu Asn 
    370                 375                 380                 


Ile Val Leu Val Leu Ala Ser Glu Ser Leu Ser Leu Leu Arg Asn Ala 
385                 390                 395                 400 


Leu Lys Ser Ala Lys Phe Asp Cys Pro Lys Glu Ala Lys Met Asp Phe 
                405                 410                 415     


Ser Met Val Asp Ile Ala Phe Trp Gln Glu Thr Glu Pro Ala Phe Arg 
            420                 425                 430         


Thr Leu Gln Glu Ala Leu Ala Val Asp Pro Leu Arg Gln Asp Thr Gln 
        435                 440                 445             


Thr Arg His Ala Val Ser Gln Trp Glu Ala Glu Leu Ala His Tyr Leu 
    450                 455                 460                 


Phe His Val Phe Asp Arg Asp Ala Leu Thr Asn Pro Asp Cys Pro Asp 
465                 470                 475                 480 


Asp Ile Leu Gln Arg Gln Leu Thr Ala Arg Gln Asp Leu Ala Ser Ser 
                485                 490                 495     


Tyr Arg Lys His Lys Ala Arg Lys Asp Val Leu Ala Leu Val Glu 
            500                 505                 510     


<210>  65
<211>  200
<212>  PRT
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  Cse2

<400>  65

Met Leu Asn Ser Asn Thr Ala Val Leu Cys Arg Ile Leu His Pro Asp 
1               5                   10                  15      


Ala Gln Lys Ala Leu Leu Asp Trp Phe Ala Thr Leu Ser Glu Arg Tyr 
            20                  25                  30          


Glu Arg Lys Asp Gly Lys Arg Val Asn Gly Arg Ala Trp Arg Ala Glu 
        35                  40                  45              


Leu Lys Arg Met Ala Pro Pro Tyr Gly Val Met Ile Cys Glu Gly His 
    50                  55                  60                  


Asp Ala Leu Arg Gln Ala Leu Leu Lys His Met Arg Leu Gln Pro Leu 
65                  70                  75                  80  


Asp Glu Met Ala Leu Ala Leu Phe Val Ser Val Ala Val His Ile Lys 
                85                  90                  95      


Ser His Lys Ala Asn Ile Ser Phe Ala Ala Gln Leu Gly Glu Lys Leu 
            100                 105                 110         


Lys Gly Ser Thr Pro Cys Val Ser Val Leu Arg Phe Glu Arg Leu Gln 
        115                 120                 125             


Lys Ala Ser Asp Pro Glu Thr Phe Cys Gln Leu Leu Ile Gln Ala Val 
    130                 135                 140                 


Lys Ile Arg Gly Thr Glu Gly Val Asn Val Leu Ser Leu Ala Asp Gly 
145                 150                 155                 160 


Ile Phe Leu Trp Met Glu Glu Trp Gln Arg Arg Glu Asn His Gln Pro 
                165                 170                 175     


Glu Phe Arg Asn Pro Phe Glu Arg Asn Arg Ile Arg Trp Ala Asn Glu 
            180                 185                 190         


Tyr Leu Ser Thr Ser Arg Gly Lys 
        195                 200 


<210>  66
<211>  354
<212>  PRT
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(354)
<223>  Cas7

<400>  66

Met Ile Met Thr Thr Phe Ile Gln Leu His Leu Leu Thr Ala Tyr Ala 
1               5                   10                  15      


Pro Ala Asn Leu Asn Arg Asp Glu Ser Gly Arg Pro Lys Thr Ala Phe 
            20                  25                  30          


Met Gly Gly Val Glu Arg Leu Arg Val Ser Ser Gln Ser Leu Lys Arg 
        35                  40                  45              


Ala Trp Arg Val Ser Glu Thr Phe Glu Ala Ala Met Asp Gly Phe Met 
    50                  55                  60                  


Gly Lys Arg Thr Arg Arg Ile Gly Val Asp Tyr Val Tyr Arg Pro Met 
65                  70                  75                  80  


Lys Asp Ala Gly Ile Glu Glu Lys Ile Ala Lys Ser Ser Ser Glu Leu 
                85                  90                  95      


Ile Ala Lys Gln Phe Gly Lys Leu Lys Ser Asp Lys Asp Ala Lys Pro 
            100                 105                 110         


Glu Lys Asn Leu Glu Ile Glu Gln Ile Val His Val Ser Asn His Glu 
        115                 120                 125             


Ile Ser Leu Ile Lys Gln Leu Val Asp Thr Leu Ile Ala Asp Lys Arg 
    130                 135                 140                 


Glu Pro Asn Asp Glu Glu Val Glu Leu Leu Arg Lys Glu Gln Arg Ser 
145                 150                 155                 160 


Val Asp Met Ala Leu Phe Gly Arg Met Leu Ala Ser Ser Pro Glu Phe 
                165                 170                 175     


Asn Val Glu Ala Ala Cys Gln Val Ser His Ala Leu Gly Val Ser Ala 
            180                 185                 190         


Val Thr Val Glu Ser Asp Phe Phe Thr Ala Val Asp Asp Leu Asn Asn 
        195                 200                 205             


Lys Glu Glu Asp Ala Gly Ser Gly His Met Gly Glu Gln Gly Phe Ala 
    210                 215                 220                 


Ser Ala Leu Phe Tyr Thr Tyr Val Cys Ile Ser Arg Asp Leu Leu Val 
225                 230                 235                 240 


Glu Asn Leu Gly Gly Asn Glu Glu Leu Ala Lys Arg Thr Ile Ala Ala 
                245                 250                 255     


Leu Thr Glu Thr Ala Leu Thr Val Ser Pro Thr Gly Lys Gln Asn Ser 
            260                 265                 270         


Phe Ala Ser Arg Ala Tyr Ala Thr Tyr Ala Leu Ala Glu Val Gly Gln 
        275                 280                 285             


Lys Gln Pro Arg Ser Leu Ala Ala Ala Phe Phe Gln Pro Val Arg Asp 
    290                 295                 300                 


Thr Asp Gln Ile Pro Ala Ala Ile Thr Arg Leu Lys Gln Gln Arg Ala 
305                 310                 315                 320 


Ser Phe Asp Asn Val Tyr Gly Asn Cys Ala Asp Asp Tyr Arg Glu Leu 
                325                 330                 335     


Asn Val Gln Glu Gly Thr Gly Ser Leu Ala Glu Leu Leu Ala Phe Val 
            340                 345                 350         


Ser Gln 
        


<210>  67
<211>  241
<212>  PRT
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(241)
<223>  Cas5

<400>  67

Met Lys Glu Tyr Leu Val Phe Gln Leu Tyr Ala Pro Leu Ala Ser Trp 
1               5                   10                  15      


Gly Glu Glu Ala Ser Gly Glu Ile Arg His Ser Ala Thr Val Pro Thr 
            20                  25                  30          


Arg Ser Ala Leu Leu Gly Leu Leu Ala Ala Ala Leu Gly Ile Arg Arg 
        35                  40                  45              


Asp Glu Glu Ala Arg Leu Asn Asn Phe Asn Arg His Tyr His Leu Ala 
    50                  55                  60                  


Val His Ala Leu Ala Ser Gln Asp Arg Trp Leu Arg Asp Tyr His Thr 
65                  70                  75                  80  


Val Ser Ala Pro Arg Glu Asn Lys Lys Asn Arg Tyr Tyr Thr Arg Arg 
                85                  90                  95      


Asp Glu Leu Thr Leu Ala Pro Asp Glu Val Gly Thr Leu Ile Ser Gln 
            100                 105                 110         


Arg Glu Tyr Arg Cys Asp Gly Tyr Trp His Val Ala Ile Ser Ala Thr 
        115                 120                 125             


Pro Asp Ala Pro His Ser Leu Ser Glu Leu Arg Glu Ala Leu Leu Thr 
    130                 135                 140                 


Pro His Phe Pro Leu Tyr Leu Gly Arg Lys Ser Cys Pro Leu Ala Leu 
145                 150                 155                 160 


Pro Leu Ala Ala Arg Leu Met Thr Gly Thr Leu Lys Glu Val Phe Thr 
                165                 170                 175     


His Ala Val Glu Glu Ile Ser Ala Ala Glu Leu Ser Gly Phe Thr Leu 
            180                 185                 190         


Arg Glu Gly Ile Cys Tyr Trp Asp Asp Pro Asp Glu Glu Ser Leu Val 
        195                 200                 205             


Trp Gln Gln Lys Gln His Ser Asn Asn Gln Pro Val Ser Arg Gln Arg 
    210                 215                 220                 


Trp Gln Phe Gly Gly Tyr Thr Arg Phe Asn Gly Pro Leu Gln Glu Arg 
225                 230                 235                 240 


Thr 
    


<210>  68
<211>  234
<212>  PRT
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(234)
<223>  Cas6

<400>  68

Met Tyr Leu Ser Arg Ile Gln Leu Arg Phe Asn Asn Leu Arg Pro Glu 
1               5                   10                  15      


Met Leu Ala Lys Trp Asn Ser Ala Arg Pro Tyr Ala Ser His Gln Trp 
            20                  25                  30          


Leu Trp Gln Leu Phe Pro Glu Gln Glu Leu Arg Gln Phe Leu Phe Arg 
        35                  40                  45              


Glu Glu Ala His Gly Gly Phe Phe Met Leu Ser Ala Ile Pro Pro Leu 
    50                  55                  60                  


Ser Gln His Ser Leu Phe Leu Ile Glu Thr Lys Pro Phe Asn Pro Gln 
65                  70                  75                  80  


Leu Thr Asn Gly Leu Glu Leu Asp Phe Gln Leu Arg Ala Asn Pro Val 
                85                  90                  95      


Ile Thr Arg Asn Gly Lys Arg Ser Asp Val Met Met Asn Ala Lys His 
            100                 105                 110         


Gln Ala Lys Ala Asn Gly Val Glu Lys Glu Arg Trp Trp Glu Leu Gln 
        115                 120                 125             


Gln Gln Ala Ala Gln Ala Trp Leu Glu Gln Gln Gly Gln Gln His Gly 
    130                 135                 140                 


Phe Arg Leu Ile Ala Pro Glu Pro Asp Asp Phe Ala Met Trp Ala Gly 
145                 150                 155                 160 


Asp Glu Tyr Ser Glu Leu Gln Ala His Cys Gly Cys Val Gln Ala Tyr 
                165                 170                 175     


Gln Gln His Arg Phe Val Arg Lys Asp Gln Gln Lys Pro Ile Thr Phe 
            180                 185                 190         


Ser Ser Val Asp Phe Ser Gly Ala Leu Cys Ile Thr Asp Ala Ala Leu 
        195                 200                 205             


Phe Lys Gln Ala Leu Phe Ser Gly Leu Gly Lys Ser Lys Ala Leu Gly 
    210                 215                 220                 


Cys Gly Met Leu Met Val Lys Arg Lys Arg 
225                 230                 


<210>  69
<211>  90
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  69
gtgttccccg cgccagcggg gataaaccgc agctttagca tcggtcgaca gcccatctgg       60

cgtgttcccc gcgccagcgg ggataaaccg                                        90


<210>  70
<211>  1518
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(1518)
<223>  Cas8

<400>  70
atggatttac ttgttgatcc atggatccct gtccgtgcgt ttgaggagag gcatccacaa       60

actattacgc tacaacgatt atgttgcagc gaagaaaaat ggctattaaa cctaccgcgc      120

gatgacatgg agctggcggc cttacaatta ctgatctgcc tgctgcaggt cacctgcgag      180

ccacgagatg acagcgaaat gcgcctaagg gttgccaggc cactttccga agaagagttc      240

gcagcattaa tgtcaccctg gcaccaaacc ttccaacttg atcatccgca aatgcctttt      300

atgcaggtaa aaggcgtgga agcgaaagag cccactccga tggaaaagct gatgaccggt      360

ttaagcgggg cgacaaattg cgctttcgtt aatcagccag ggcagggcga agcgttatgc      420

ggtggttgta cggcgatagc gctgtttaat caggcaaata acgccccagg ttttggaggc      480

ggttttaaga gtggattacg gggcggtacg ccgattacta ctttaattaa aggctcagat      540

ctgcgtacca ctatctggct aaatgtcctg accacaccgc gtcttcaatc ctctttcccg      600

ccagatagac ttaccgaaaa tcttcccacc tggaaacgcc ctatatccag tggaaaaaca      660

tttcctgccg ccacgattgg tttactgcgc gggctttttt ggcaacccgc acacattgaa      720

ctttgcccgc ctataggccc ggggcaatgt tgcgggtgcg gacagcagag caaccagcgt      780

tataacggtt ttctcaaggc taaattcaac tttacggttg aaggattatg gcctcatcca      840

cattccccgc gcgttctggt tgagaaaaaa ggcgttattg aacaaaagtt tctcgccttt      900

accaccgcag cgccttcatg gacgcaaata ggtcgcctac tggtggacaa agaaacccgg      960

caaggtgaag ggcgtcgggt ggcgacggtg gttgaacaat tcagggaggt gtacccgcgc     1020

ttcaggctgg cattgatcgt cggtggatat cgtaataatc aggcttctat tctggagcgt     1080

cgccacgatg tgctggtttt caatgatgga tggcaaaacg gtagcgatgt gatcaatgac     1140

attgttgaaa tggggctggg atacaaaact gctttgcgaa aagggttgta caccttcgtt     1200

gagggggcaa aaaatcacga tgttaaaggg gcgggtgtag cggtacacga agtggctgaa     1260

cgacattatt accgccgcag cgaactgctt attcccgcga tcctggcaag cattgattat     1320

tctcagccaa atgatgtcat tgcacgtctg agaaaagagc ttcatcaact ttgcgaagcg     1380

ctcttcaacc aggttactgc cccatatgcc catcatccca aattgatccg ctcattagca     1440

gtggcgcgcg cttcgcttca taaacatctc aatgaactta aaccacaagg agagttagcg     1500

tatgtcgacg gagattga                                                   1518


<210>  71
<211>  492
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(492)
<223>  Cse2

<400>  71
atgtcgacgg agattgatgc aatggcgctc tataacgcct ggcagcaatt agataacggc       60

tcaagtgccc agctaagacg ggtaagcgag cctgatgagt tacgcgagat ccccgccttt      120

tatcgtctcg tccaaccctt tggctgggag aatcctgcca ataagcgtcc gttactgcgt      180

atggtttttt gcctgagcgc gggtaaagac gtcattcatc ataaagagaa aatcgatgat      240

tatccgtcag gcattagcct cggaagagcg ctggcaaaga gtggaaagat taacgaacgc      300

cgcgtttttc agcttgtccg tgcacagagt cccggcgaca tgattcaact gcgacggtta      360

ttaattcatg cagagcctgt tcttgactgg tctttattcg cccggcaact cacctggtgg      420

ggcaaacgag agcgccagca actgctggaa gattttatgt tggctacccc tgaatcaaac      480

aaaaaagcgt aa                                                          492


<210>  72
<211>  1098
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(1098)
<223>  Cas7

<400>  72
atgaacaact ttatcaactt tcatgtcctg atttctcaca gcccttcttg cctgaaccgc       60

gacgatatga atatgcaaaa agacgcggtt ttcggcggca agcggcgtgt gcgtatttcg      120

agccagagct taaaacgtgc gatgcgcaaa agtgattact atgcccgtca tattggcgca      180

tccagtcttc gcactatcca tcttgaagag ctgcgtgacg tattacgtca aaaattatcc      240

ccgcgattcg aattgccgat aatcgataaa acgctgtctt tgttatcagg aaaaaccatt      300

gatgatgctg aaaaaattaa cggcgacgca gtaacgcctt gggtattggg cgaagtcgaa      360

tggttttgcg aacaggtaat gaaagcggaa gctgagcaac tggatgataa aaaactgctc      420

aaaatgctta aagatgatat tgccgcgatg cgcaccaatc ttcagcaggg ggttgatgtt      480

gcactgagcg gacgcatggc gaccagcggc ctgatgagcg aactcgggaa agttgatggt      540

gcaatgtcca ttgctcatgc catcaccaca catactgttg attccgatat tgactggttt      600

acagcagtag acgatctcca ggacttaggt tcggcgcacc ttggaaccca ggaattttct      660

tccggcgtgt tttatcgcta cgccagtctg aatattgccc agcttcagga gaaccttggc      720

ggtgtatctc gcgagcaggt ccttgaaatc gcagcgcatc ttgcgcatat gctggcgact      780

gaagtaccgg gcgcgaagca acataccttc gcggcattca acccggcgga catggtcatg      840

atcaattttt ctgatttccc cctttcgtta gccaatgctt ttgaaagccc gattaaagcc      900

aaagatggct atttgttacc ttctatcaac gcctttaatg agtactggca gcgtatagct      960

aaagggtatg gattaacagg accggcggca cagtttatgt tggccgaagc aagtatggcg     1020

ggcggaaatg tggtgtctgt tgagacactg gaacaactta aaaaatggat ttgccatgat     1080

ggcgaggcgt caagatga                                                   1098


<210>  73
<211>  675
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(675)
<223>  Cas5

<400>  73
atgaaaccct acttaatcct gcggcttgcg ggaccgatgc aggcgtgggg gcaaccaaca       60

tttgagggca cacgaccgac agcgcgcttc cccacacgca gcggccttct tgggttgctg      120

ggcgcttgcc tgggcattca acgagacgac cgctcagcgt tacaggcgct ctctgaaagc      180

gtcaggtttg cggttcgttg cgaccagtca tttattgatg ggcgaaccat tcccgttacc      240

ggcttgcgtg attaccatac ggttatggat gcacgagagg attatcgtgg cttaaaaagc      300

cacgaaacca ttcagacctg gcgcgaatac ttgtgtgacg cggttttcac cgtggcggta      360

tgggagtctg aacaggcaac tctcaggctc ccggagctga aagttgcggt atgcaaacct      420

cgttttacgc cttttttggg acgtaaaagc tgcccgttaa cacagccgct ctttgttgat      480

ctttgtgatg ccatcaatcc gtatcaggcg ttggcaaatt atgctccagc aggaggagat      540

atttatagcg aagcgccgcc tgacggaccg tgccaaacat tcaccgtacg tgatgagccg      600

attattgcct taccgcgaca atttgccgcc agggagtggt acgtcataaa aggagcctcg      660

gatgtatctc agtaa                                                       675


<210>  74
<211>  600
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(600)
<223>  Cas6

<400>  74
atgtatctca gtaaggtcat tattcagaac gcctggtgcc gggatgttta tcaatttcat       60

caggctatct ggcagctttt tccttctcaa cctgcccaaa aaagagcgtt tttatttcgt      120

attgaggcta aacatcccgg cagaggcgct gatgtattac ttcaatcgat ggaagcccct      180

gcttcatcgg ctgccgcgca agttcttgcc tgtaaacctt tagcatttca cctaaaagag      240

ggggatcagt tgcgcttccg tctgcgtgcc aacccaataa aaacgattaa agatgagcaa      300

caacgtctga atggtcgtgg ggaaatcaaa cgctgccgtg tgccactact taaagagcag      360

gaacaacacc agtggttaat acgaaaatta tcacttgcgg ctcgtctgga acatattgaa      420

tccactagtg agcttccgtt gtttttttct aaaaatggta cgggtgggaa aattcagccc      480

atgaattttg aaggcattct taccgtaacc agtgtgccgg cattgctgtc gctattaaat      540

aatggagtgg gtccggcaaa agcaatggga tgtgggctgt tatcacttgc ccgcccctga      600


<210>  75
<211>  1518
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(1518)
<223>  Cas8

<400>  75
atggatctgc tggtggaccc atggattccc gtgcgggcct ttgaggagag gcaccctcag       60

accatcacac tgcagcggct gtgctgttcc gaggagaagt ggctgctgaa tctgccaaga      120

gacgatatgg agctggccgc cctgcagctg ctgatctgcc tgctgcaggt gacctgtgag      180

cctagggacg attctgagat gaggctgcgg gtggcaaggc cactgtctga ggaggagttc      240

gccgccctga tgagcccttg gcaccagaca tttcagctgg accaccctca gatgccattc      300

atgcaggtga agggcgtgga ggccaaggag ccaaccccca tggagaagct gatgaccggc      360

ctgagcggcg ccacaaactg tgcctttgtg aatcagccag gacagggaga ggccctgtgc      420

ggaggatgta cagcaatcgc cctgttcaac caggcaaaca atgcaccagg atttggagga      480

ggcttcaaga gcggcctgag gggaggaacc cctatcacca cactgatcaa gggctccgat      540

ctgcgcacca caatctggct gaacgtgctg accacacccc ggctgcagtc ctcttttcct      600

ccagacagac tgaccgagaa tctgcccaca tggaagaggc ctatcagctc cggcaagacc      660

tttcctgcag caacaatcgg actgctgagg ggactgttct ggcagcctgc acacatcgag      720

ctgtgcccac ctatcggacc aggacagtgc tgtggatgtg gacagcagtc caaccagcgg      780

tacaatggct tcctgaaggc caagtttaat ttcacagtgg agggactgtg gcctcaccca      840

cactccccca gagtgctggt ggagaagaag ggcgtgatcg agcagaagtt tctggccttc      900

accacagccg ccccttcttg gacccagatc ggcaggctgc tggtggataa ggagacccgc      960

cagggagagg gcaggcgcgt ggccacagtg gtggagcagt ttcgggaggt gtaccctaga     1020

ttcaggctgg ccctgatcgt gggcggctat agaaacaatc aggccagcat cctggagcgg     1080

agacacgatg tgctggtgtt taacgacggc tggcagaatg gctccgatgt gatcaacgac     1140

atcgtggaga tgggcctggg ctacaagacc gccctgagga agggcctgta tacattcgtg     1200

gagggcgcca agaatcacga cgtgaaggga gcaggagtgg cagtgcacga ggtggccgag     1260

cgccactact ataggcgcag cgagctgctg atcccagcaa tcctggcctc catcgattat     1320

tctcagccta acgacgtgat cgcaaggctg cggaaggagc tgcaccagct gtgcgaggcc     1380

ctgttcaatc aggtgaccgc accatacgca caccacccaa agctgatccg gtctctggca     1440

gtggcaagag ccagcctgca caagcacctg aacgagctga agccacaggg agagctggca     1500

tacgtggatg gcgactaa                                                   1518


<210>  76
<211>  492
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(492)
<223>  Cse2

<400>  76
atgagcaccg agatcgatgc catggccctg tataacgcct ggcagcagct ggacaatggc       60

agctccgccc agctgaggcg cgtgagcgag cctgatgagc tgagggagat cccagccttt      120

taccgcctgg tgcagccatt cggctgggag aaccccgcca ataagcgccc tctgctgcgg      180

atggtgtttt gcctgtccgc cggcaaggac gtgatccacc acaaggagaa gatcgacgat      240

tacccatccg gcatctctct gggacgggcc ctggcaaagt ctggcaagat caacgagcgg      300

agagtgttcc agctggtgag agcccagagc ccaggcgata tgatccagct gaggcgcctg      360

ctgatccacg cagagcccgt gctggactgg agcctgtttg caaggcagct gacctggtgg      420

ggcaagaggg agagacagca gctgctggag gatttcatgc tggccacacc cgagagcaac      480

aagaaggcat aa                                                          492


<210>  77
<211>  1098
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(1098)
<223>  Cas7

<400>  77
atgaacaact tcatcaactt ccacgtgctg atctctcaca gcccatcctg cctgaaccgg       60

gacgatatga atatgcagaa ggatgccgtg ttcggcggca agcggagagt gagaatcagc      120

tcccagtccc tgaagagagc catgaggaag tctgactact atgcaaggca catcggagca      180

tctagcctgc gcacaatcca cctggaggag ctgagagatg tgctgaggca gaagctgtcc      240

cctcgctttg agctgccaat catcgacaag accctgtccc tgctgtctgg caagacaatc      300

gacgatgccg agaagatcaa cggcgacgca gtgaccccat gggtgctggg agaggtggag      360

tggttctgtg agcaggtcat gaaggccgag gccgagcagc tggacgataa gaagctgctg      420

aagatgctga aggacgatat cgccgccatg aggaccaatc tgcagcaggg agtggatgtg      480

gccctgagcg gcaggatggc cacatctggc ctgatgagcg agctgggcaa ggtggacgga      540

gcaatgtcca tcgcacacgc catcaccaca cacaccgtgg actctgatat cgactggttt      600

acagccgtgg acgatctgca ggatctgggc tccgcccacc tgggaaccca ggagttttcc      660

tctggcgtgt tctacagata tgcctccctg aacatcgccc agctgcagga gaatctggga      720

ggcgtgtctc gcgagcaggt gctggagatc gcagcacacc tggcacacat gctggcaacc      780

gaggtgccag gagcaaagca gcacacattt gccgccttca accccgccga tatggtcatg      840

atcaacttca gcgacttccc actgtccctg gccaacgcct ttgagagccc catcaaggcc      900

aaggacggct acctgctgcc ttccatcaac gccttcaatg agtactggca gcggatcgcc      960

aagggatatg gactgaccgg accagcagca cagttcatgc tggcagaggc cagcatggca     1020

ggaggaaacg tggtgtccgt ggagaccctg gagcagctga agaagtggat ctgccacgat     1080

ggagaggcca gccggtaa                                                   1098


<210>  78
<211>  675
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(675)
<223>  Cas5

<400>  78
atgaagccat atctgatcct gagactggca ggaccaatgc aggcctgggg acagcctacc       60

tttgagggca ccagaccaac agcaaggttc ccaacacgct ccggcctgct gggactgctg      120

ggagcatgcc tgggcatcca gagggacgat cggtctgccc tgcaggccct gtctgagagc      180

gtgcggtttg ccgtgagatg tgatcagagc ttcatcgacg gccggaccat ccctgtgaca      240

ggcctgagag attaccacac cgtgatggat gccagggagg actatcgcgg cctgaagtct      300

cacgagacca tccagacatg gagggagtac ctgtgcgacg ccgtgtttac cgtggccgtg      360

tgggagagcg agcaggccac actgaggctg ccagagctga aggtggccgt gtgcaagccc      420

cggtttaccc ctttcctggg cagaaagtcc tgcccactga cacagcccct gttcgtggac      480

ctgtgcgacg ccatcaaccc ttaccaggcc ctggcaaatt atgcacctgc aggaggcgat      540

atctattctg aggcacctcc agacggacca tgccagacct ttacagtgcg ggacgagcct      600

atcatcgccc tgccaaggca gttcgcagca agggagtggt acgtgatcaa gggagcaagc      660

gacgtgagcc agtaa                                                       675


<210>  79
<211>  600
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(600)
<223>  Cas6

<400>  79
atgtacctga gcaaagtgat catccagaat gcctggtgtc gcgacgtgta ccagtttcac       60

caggccatct ggcagctgtt cccctctcag cctgcccaga agcgggcctt cctgtttaga      120

atcgaggcaa agcacccagg aaggggagca gacgtgctgc tgcagagcat ggaggcacca      180

gcatctagcg ccgcagcaca ggtgctggcc tgcaagcccc tggcctttca cctgaaggag      240

ggcgatcagc tgaggttccg cctgagggcc aacccaatca agaccatcaa ggacgagcag      300

cagcggctga atggcagagg cgagatcaag agatgtaggg tgcccctgct gaaggagcag      360

gagcagcacc agtggctgat caggaagctg tccctggcag cacgcctgga gcacatcgag      420

tccacctctg agctgcccct gttcttttct aagaacggca caggcggcaa gatccagcct      480

atgaatttcg agggcatcct gaccgtgaca agcgtgcctg ccctgctgtc cctgctgaac      540

aatggagtgg gaccagcaaa ggcaatggga tgcggcctgc tgtctctggc aaggccataa      600


<210>  80
<211>  505
<212>  PRT
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(505)
<223>  Cas8

<400>  80

Met Asp Leu Leu Val Asp Pro Trp Ile Pro Val Arg Ala Phe Glu Glu 
1               5                   10                  15      


Arg His Pro Gln Thr Ile Thr Leu Gln Arg Leu Cys Cys Ser Glu Glu 
            20                  25                  30          


Lys Trp Leu Leu Asn Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Gln Leu Leu Ile Cys Leu Leu Gln Val Thr Cys Glu Pro Arg Asp Asp 
    50                  55                  60                  


Ser Glu Met Arg Leu Arg Val Ala Arg Pro Leu Ser Glu Glu Glu Phe 
65                  70                  75                  80  


Ala Ala Leu Met Ser Pro Trp His Gln Thr Phe Gln Leu Asp His Pro 
                85                  90                  95      


Gln Met Pro Phe Met Gln Val Lys Gly Val Glu Ala Lys Glu Pro Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Met Thr Gly Leu Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Asn Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Ile Thr Thr Leu Ile 
                165                 170                 175     


Lys Gly Ser Asp Leu Arg Thr Thr Ile Trp Leu Asn Val Leu Thr Thr 
            180                 185                 190         


Pro Arg Leu Gln Ser Ser Phe Pro Pro Asp Arg Leu Thr Glu Asn Leu 
        195                 200                 205             


Pro Thr Trp Lys Arg Pro Ile Ser Ser Gly Lys Thr Phe Pro Ala Ala 
    210                 215                 220                 


Thr Ile Gly Leu Leu Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Pro Pro Ile Gly Pro Gly Gln Cys Cys Gly Cys Gly Gln Gln 
                245                 250                 255     


Ser Asn Gln Arg Tyr Asn Gly Phe Leu Lys Ala Lys Phe Asn Phe Thr 
            260                 265                 270         


Val Glu Gly Leu Trp Pro His Pro His Ser Pro Arg Val Leu Val Glu 
        275                 280                 285             


Lys Lys Gly Val Ile Glu Gln Lys Phe Leu Ala Phe Thr Thr Ala Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Gly Arg Leu Leu Val Asp Lys Glu Thr Arg 
305                 310                 315                 320 


Gln Gly Glu Gly Arg Arg Val Ala Thr Val Val Glu Gln Phe Arg Glu 
                325                 330                 335     


Val Tyr Pro Arg Phe Arg Leu Ala Leu Ile Val Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Val Phe Asn 
        355                 360                 365             


Asp Gly Trp Gln Asn Gly Ser Asp Val Ile Asn Asp Ile Val Glu Met 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Gly Leu Tyr Thr Phe Val 
385                 390                 395                 400 


Glu Gly Ala Lys Asn His Asp Val Lys Gly Ala Gly Val Ala Val His 
                405                 410                 415     


Glu Val Ala Glu Arg His Tyr Tyr Arg Arg Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Ala Ile Leu Ala Ser Ile Asp Tyr Ser Gln Pro Asn Asp Val Ile Ala 
        435                 440                 445             


Arg Leu Arg Lys Glu Leu His Gln Leu Cys Glu Ala Leu Phe Asn Gln 
    450                 455                 460                 


Val Thr Ala Pro Tyr Ala His His Pro Lys Leu Ile Arg Ser Leu Ala 
465                 470                 475                 480 


Val Ala Arg Ala Ser Leu His Lys His Leu Asn Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Glu Leu Ala Tyr Val Asp Gly Asp 
            500                 505 


<210>  81
<211>  163
<212>  PRT
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(163)
<223>  Cse2

<400>  81

Met Ser Thr Glu Ile Asp Ala Met Ala Leu Tyr Asn Ala Trp Gln Gln 
1               5                   10                  15      


Leu Asp Asn Gly Ser Ser Ala Gln Leu Arg Arg Val Ser Glu Pro Asp 
            20                  25                  30          


Glu Leu Arg Glu Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly 
        35                  40                  45              


Trp Glu Asn Pro Ala Asn Lys Arg Pro Leu Leu Arg Met Val Phe Cys 
    50                  55                  60                  


Leu Ser Ala Gly Lys Asp Val Ile His His Lys Glu Lys Ile Asp Asp 
65                  70                  75                  80  


Tyr Pro Ser Gly Ile Ser Leu Gly Arg Ala Leu Ala Lys Ser Gly Lys 
                85                  90                  95      


Ile Asn Glu Arg Arg Val Phe Gln Leu Val Arg Ala Gln Ser Pro Gly 
            100                 105                 110         


Asp Met Ile Gln Leu Arg Arg Leu Leu Ile His Ala Glu Pro Val Leu 
        115                 120                 125             


Asp Trp Ser Leu Phe Ala Arg Gln Leu Thr Trp Trp Gly Lys Arg Glu 
    130                 135                 140                 


Arg Gln Gln Leu Leu Glu Asp Phe Met Leu Ala Thr Pro Glu Ser Asn 
145                 150                 155                 160 


Lys Lys Ala 
            


<210>  82
<211>  365
<212>  PRT
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(365)
<223>  Cas7

<400>  82

Met Asn Asn Phe Ile Asn Phe His Val Leu Ile Ser His Ser Pro Ser 
1               5                   10                  15      


Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Asp Ala Val Phe Gly 
            20                  25                  30          


Gly Lys Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met 
        35                  40                  45              


Arg Lys Ser Asp Tyr Tyr Ala Arg His Ile Gly Ala Ser Ser Leu Arg 
    50                  55                  60                  


Thr Ile His Leu Glu Glu Leu Arg Asp Val Leu Arg Gln Lys Leu Ser 
65                  70                  75                  80  


Pro Arg Phe Glu Leu Pro Ile Ile Asp Lys Thr Leu Ser Leu Leu Ser 
                85                  90                  95      


Gly Lys Thr Ile Asp Asp Ala Glu Lys Ile Asn Gly Asp Ala Val Thr 
            100                 105                 110         


Pro Trp Val Leu Gly Glu Val Glu Trp Phe Cys Glu Gln Val Met Lys 
        115                 120                 125             


Ala Glu Ala Glu Gln Leu Asp Asp Lys Lys Leu Leu Lys Met Leu Lys 
    130                 135                 140                 


Asp Asp Ile Ala Ala Met Arg Thr Asn Leu Gln Gln Gly Val Asp Val 
145                 150                 155                 160 


Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Leu Met Ser Glu Leu Gly 
                165                 170                 175     


Lys Val Asp Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Thr 
            180                 185                 190         


Val Asp Ser Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Asp 
        195                 200                 205             


Leu Gly Ser Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe 
    210                 215                 220                 


Tyr Arg Tyr Ala Ser Leu Asn Ile Ala Gln Leu Gln Glu Asn Leu Gly 
225                 230                 235                 240 


Gly Val Ser Arg Glu Gln Val Leu Glu Ile Ala Ala His Leu Ala His 
                245                 250                 255     


Met Leu Ala Thr Glu Val Pro Gly Ala Lys Gln His Thr Phe Ala Ala 
            260                 265                 270         


Phe Asn Pro Ala Asp Met Val Met Ile Asn Phe Ser Asp Phe Pro Leu 
        275                 280                 285             


Ser Leu Ala Asn Ala Phe Glu Ser Pro Ile Lys Ala Lys Asp Gly Tyr 
    290                 295                 300                 


Leu Leu Pro Ser Ile Asn Ala Phe Asn Glu Tyr Trp Gln Arg Ile Ala 
305                 310                 315                 320 


Lys Gly Tyr Gly Leu Thr Gly Pro Ala Ala Gln Phe Met Leu Ala Glu 
                325                 330                 335     


Ala Ser Met Ala Gly Gly Asn Val Val Ser Val Glu Thr Leu Glu Gln 
            340                 345                 350         


Leu Lys Lys Trp Ile Cys His Asp Gly Glu Ala Ser Arg 
        355                 360                 365 


<210>  83
<211>  224
<212>  PRT
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(224)
<223>  Cas5

<400>  83

Met Lys Pro Tyr Leu Ile Leu Arg Leu Ala Gly Pro Met Gln Ala Trp 
1               5                   10                  15      


Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Ala Arg Phe Pro Thr 
            20                  25                  30          


Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu Gly Ile Gln Arg 
        35                  40                  45              


Asp Asp Arg Ser Ala Leu Gln Ala Leu Ser Glu Ser Val Arg Phe Ala 
    50                  55                  60                  


Val Arg Cys Asp Gln Ser Phe Ile Asp Gly Arg Thr Ile Pro Val Thr 
65                  70                  75                  80  


Gly Leu Arg Asp Tyr His Thr Val Met Asp Ala Arg Glu Asp Tyr Arg 
                85                  90                  95      


Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg Glu Tyr Leu Cys 
            100                 105                 110         


Asp Ala Val Phe Thr Val Ala Val Trp Glu Ser Glu Gln Ala Thr Leu 
        115                 120                 125             


Arg Leu Pro Glu Leu Lys Val Ala Val Cys Lys Pro Arg Phe Thr Pro 
    130                 135                 140                 


Phe Leu Gly Arg Lys Ser Cys Pro Leu Thr Gln Pro Leu Phe Val Asp 
145                 150                 155                 160 


Leu Cys Asp Ala Ile Asn Pro Tyr Gln Ala Leu Ala Asn Tyr Ala Pro 
                165                 170                 175     


Ala Gly Gly Asp Ile Tyr Ser Glu Ala Pro Pro Asp Gly Pro Cys Gln 
            180                 185                 190         


Thr Phe Thr Val Arg Asp Glu Pro Ile Ile Ala Leu Pro Arg Gln Phe 
        195                 200                 205             


Ala Ala Arg Glu Trp Tyr Val Ile Lys Gly Ala Ser Asp Val Ser Gln 
    210                 215                 220                 


<210>  84
<211>  199
<212>  PRT
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(199)
<223>  Cas6

<400>  84

Met Tyr Leu Ser Lys Val Ile Ile Gln Asn Ala Trp Cys Arg Asp Val 
1               5                   10                  15      


Tyr Gln Phe His Gln Ala Ile Trp Gln Leu Phe Pro Ser Gln Pro Ala 
            20                  25                  30          


Gln Lys Arg Ala Phe Leu Phe Arg Ile Glu Ala Lys His Pro Gly Arg 
        35                  40                  45              


Gly Ala Asp Val Leu Leu Gln Ser Met Glu Ala Pro Ala Ser Ser Ala 
    50                  55                  60                  


Ala Ala Gln Val Leu Ala Cys Lys Pro Leu Ala Phe His Leu Lys Glu 
65                  70                  75                  80  


Gly Asp Gln Leu Arg Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile 
                85                  90                  95      


Lys Asp Glu Gln Gln Arg Leu Asn Gly Arg Gly Glu Ile Lys Arg Cys 
            100                 105                 110         


Arg Val Pro Leu Leu Lys Glu Gln Glu Gln His Gln Trp Leu Ile Arg 
        115                 120                 125             


Lys Leu Ser Leu Ala Ala Arg Leu Glu His Ile Glu Ser Thr Ser Glu 
    130                 135                 140                 


Leu Pro Leu Phe Phe Ser Lys Asn Gly Thr Gly Gly Lys Ile Gln Pro 
145                 150                 155                 160 


Met Asn Phe Glu Gly Ile Leu Thr Val Thr Ser Val Pro Ala Leu Leu 
                165                 170                 175     


Ser Leu Leu Asn Asn Gly Val Gly Pro Ala Lys Ala Met Gly Cys Gly 
            180                 185                 190         


Leu Leu Ser Leu Ala Arg Pro 
        195                 


<210>  85
<211>  90
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  85
gtgttccccg cgccagcggg gataaaccgt tttaaaacag gatgtggccc gcctggtgct       60

ggtgttcccc gcgccagcgg ggataaaccg                                        90


<210>  86
<211>  1512
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(1512)
<223>  Cas8

<400>  86
atgaatctat tgaccgatcc gtggataccg gcacggcccc aaggcagggc gacagcgcag       60

aagttgacct tgcgacagct gctgtgtgaa gacgaacgct gggagttgcg tctgccacgt      120

gatgacatgg agatggcaac actgcaattg ctgatctgcc tgacccaggc gttggcaacg      180

ccggcagatt tgccggagct gaaacgacga attatgaagc ctttgggaca gcaggagttc      240

aatgccgcct acactccttt cgcggactgg ttccggctcg atcatccgca gtatccgttc      300

atgcaggtgc ggggagtgaa ggcgaaggag ccgacgccga tggataaact gctggccggg      360

ttgacggggg cgaccaacag ctgtttcgtc aaccaatcgg gattgggcga ggggctttgc      420

ccggcttgcg ctgctatcgc tttgtttaac caggcgatga atgtccctgg attcggtggg      480

ggattcaaag ccagtttgcg cggcagtgct ccggtcacca cactggtaca aggcgaacac      540

ctgcggcaaa ccatctggtt gaatgtgctg agcacggagt cggtcgaagc tctgcttccc      600

tggcatcggc aaacggaaga ccagaaaccg acctggatag ctccaatcaa atccgaaacc      660

ttttcatccc gaagtatcgg gtttctgcgg ggtctgttct ggcagccggc gcacattgag      720

ttgctgcccg ctgagtcggt cggagattgc agttgctgcg gtcaggggga cacggaagtg      780

tatcgcggat tcaataaggc gaaattcaat tacaccgtga ccggcatttg gccgcatcct      840

catggggcga gaacctctac tgtgaaaaag ggggaacagg aagagaagtt cgtttctttc      900

accaccgaag ctccctcctg gactcagttg ggtcgtttcg tggcacgccg tgcctttgtt      960

gacgccaaaa ctcccggtca ggaaccggcg gcggtgatcc gtcaggcgca aaaacttggt     1020

gtgcggttga ctctctgcat cggtggatat cgcaacaacc aagcctcgat tctggagcga     1080

cggcatgagt tgctacccct tggcgagggg tggaattcga aaccccagat tgttcaggat     1140

gttgtggata ctgccatcgg ctatcgcgat gcgctgaaca agtcactgta ttcctttttc     1200

aagggaggag ggagcaaggg cgccgggctg ccgatccatg aattcggcaa ggcccaattc     1260

taccgccgaa cggaagaagc catcctcgac agcttggctc gtctcgattt cagtaatcca     1320

cgtccggttc tactcgcgct tcagaaaaaa ctggatacag aggtcagggg actgtttgag     1380

gaagcggtcc gtccctatct gaacgacccc aacctgattc ataccatggc ggtttcccgc     1440

cggactttat acaaaaatct caacgtactg aaacctcaac aggagggagg agtcgatggc     1500

aaaagaaact ga                                                         1512


<210>  87
<211>  480
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(480)
<223>  Cse2

<400>  87
atggcaaaag aaactgattt tatggatctg tatcaggcct ggcagcgatt gccgaacggg       60

ccaaaagccg agcttaagcg atgcggcgac ttgggtgatc tgcttgaaac ctcggcgttt      120

tatcgtctgc tcgccgggcg gggtgaagcg gaatggcaga agaaagctta tcagcgcatg      180

atcttctgcc tcccctgcat caaccacacg gaacagaaaa tccctctggg cgctgcgctg      240

gcgagaagtc gcaaggggag ccggtcggcg gtttcagaaa gccgtatgat tcaagttgtg      300

cgcagcgaag cgccgaacga catggttcag ttgcggcgga ttctcaagca cgccgaaccg      360

acagtcaact ggccgctgat ggcaaaacag ctttggtact gggatctcaa cgaacgcagt      420

aaacggagtt tgctcgaaga tttctttctc aatcacaccg acacatcaaa ggagggttaa      480


<210>  88
<211>  1095
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(1095)
<223>  Cas7

<400>  88
gtgcagaatt tcatcaacta tcacgttctc atttcgcaca gtccgtcttg cctcaaccgc       60

gacgacatga atatgcagaa gtcagccatc ttcggtggtg tgcgccgagt acggatttca      120

agccagagtc tgaaacgggc gatgcgtaaa agcgactatt atgctcagca ccttggtgaa      180

gcgagtatcc gcacaaagca tttgagtgga ctgcgggatc ggttgcacga aaggctggcg      240

gggcgttttt ctcccgaagt tatcgataaa actatcaagc tgctcatcga caaggacgtt      300

tccgtcgatg gaatcgtcga aggcgatgcc gtggcccctt gggcggtgga agagtttgcc      360

tggttctgcg agcgggttat gaatgcgcag gcggaagggc tggaagacaa ggctctgacc      420

aagcagttga aagaatctat cgccgcgatg cgacagacgc tggttggcgg gcttgatatc      480

gcattatccg ggcggatggc cacctcgggg ttgctcagtg aacttggcaa ggtcgatggt      540

gcgctggccg tggcgcatgc cttgaccacc cacacggttg atgccgatat cgactggttc      600

accgctgtgg atgatctgca ggaactggga tctgggcacc tcgacaccca ggaattctct      660

agtggggtgt tctatcgcta cgccagtctg aacatcggcc agttgcagga aaacctcggt      720

ggcgcaccac gcgaacaggc gctggagatt gccacgcacg tattgcagat gttggcgacg      780

gtagttccgt ctgctaagca gcagagtttt gccgcgcaca accttgctga cttggcgttg      840

gtttccttcg ccgatatccc ggtatcgctg gccaatgcct tcgaaaaacc ggtgcagcag      900

aaaaacggca gtggattccg tgaaccttcg attgctgcgc tgcacgacta ttggcagaag      960

gtgcatatcg gctacgggct ggaagaacgc tgcgggcagt ttgttttgaa caaagtggaa     1020

acgcctgccg ggatcgctgc gaaagagagc cttgaggacc tcaaaagttg ggtgcgcaac     1080

aacggagagg ggtga                                                      1095


<210>  89
<211>  678
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(678)
<223>  Cas5

<400>  89
atgggcgact acctgattct gaaactgcag gggccgatgc aggcctgggg ggagcacagc       60

tttgaaggga cgcgcccttc gggcaacttc ccgacccgta gtgccctgct cggacttctt      120

ggtgcctgtc tcggcattcg ccggaatgaa tacgaacgtt tgcagcaatt ggcggacagc      180

gttcaatttg ccgtgcgtaa agatgctcgc cagacgcaaa ccgagtgggg ggagccgaaa      240

aagctgccga tggtcaagat gactgattac cacaccgtca aggacgcacg gcagagttac      300

attggcctca aaagccacga aaccattcag acctggcggg aatatctgct tgatgcggaa      360

tacagcgttg ctatctggga aaacgaggat gcagccgtgt cactggatga attggaaacg      420

gccgtgcgca aaccggtatt caccccttat cttgggcgac ggagctgtcc gttggcgcaa      480

ccgctgtttg gcaaaaggct taccgcggaa agtccgaacc aggccttgca ggctgttgaa      540

ccgagcggcg gtgtgattta cagcgaacag ccatcagatc gcagcatgcg cctgcgtgac      600

ctgccgatgg cgggtcaacc acgccagttc gcttcccgca ccgtctacat ccacggaggg      660

gatcatgtat ctgagtaa                                                    678


<210>  90
<211>  609
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(609)
<223>  Cas6

<400>  90
atgtatctga gtaaggttat ggtgactggg gccgcctgtc gcaatcccta tgaaatccac       60

cgcagcctct ggcaactgtt tccagaagat cccgacgcca ggcgagacta cttgtttcgc      120

gtagagcgcg ccgggcggca gcaggctgaa atcttgttac agtcgcagcg aaaaccgagc      180

gattcagagt tgcgtaaggt ccgactgctg gcgacgcgag ggtatcaacc gaggctgcag      240

caggggcaac ggctgcgttt tgcgttgctg gccaacccgg tcaagaccat caacgatgaa      300

cgcggccgcc tgaatgccaa aggccaggtg aaaaaatgcc gggttccgct gattcgcgag      360

gaggaatggc ggagctggtt ggagcacaag ctgattggtt gtgcggagct ggagacgctg      420

gtcgctgaaa atcgtctgcc gataaatttc cgcaagccca aggaaaaacg tgtcgggaaa      480

attcagccgg tcagttttca ggggatttta cgggtatcta gcccggaagc tatgatgcag      540

gcaatctcta ccggcatcgg cccggctaaa gccttcggtt gcggcctgct gtcaatcgcc      600

cctgcgtga                                                              609


<210>  91
<211>  1512
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(1512)
<223>  Cas8

<400>  91
atgaacctgc tgacagatcc ctggattccc gcaaggccac agggaagggc aaccgcacag       60

aagctgacac tgagacagct gctgtgcgag gacgagaggt gggagctgag actgcccagg      120

gacgatatgg agatggccac cctgcagctg ctgatctgtc tgacccaggc cctggcaaca      180

ccagcagatc tgcccgagct gaagcggaga atcatgaagc ccctgggcca gcaggagttt      240

aatgccgcct acaccccttt tgccgattgg ttccgcctgg accaccccca gtatcctttc      300

atgcaggtgc ggggagtgaa ggcaaaggag ccaacaccca tggacaagct gctggcagga      360

ctgaccggag caacaaacag ctgttttgtg aatcagtccg gcctgggaga gggactgtgc      420

ccagcctgtg ccgccatcgc cctgttcaac caggccatga atgtgcctgg ctttggagga      480

ggcttcaagg cctctctgag gggcagcgcc ccagtgacca cactggtgca gggagagcac      540

ctgaggcaga ccatctggct gaacgtgctg tctacagaga gcgtggaggc cctgctgcca      600

tggcacaggc agaccgagga ccagaagccc acatggatcg cccctatcaa gagcgagacc      660

ttcagctcca gatccatcgg ctttctgagg ggactgttct ggcagccagc acacatcgag      720

ctgctgcctg cagagagcgt gggcgattgc tcctgctgtg gccagggcga cacagaggtg      780

tacaggggct ttaacaaggc caagttcaat tataccgtga caggaatctg gcctcaccca      840

cacggagcac gcaccagcac agtgaagaag ggcgagcagg aggagaagtt cgtgagcttc      900

accacagagg cacctagctg gacccagctg ggccgctttg tggcaaggag ggccttcgtg      960

gatgcaaaga cacctggaca ggagccagca gccgtgatca ggcaggcaca gaagctgggc     1020

gtgcggctga ccctgtgcat cggaggctat aggaacaatc aggccagcat cctggagcgg     1080

agacacgagc tgctgccact gggagaggga tggaattcca agccccagat cgtgcaggat     1140

gtggtggaca cagccatcgg ctaccgcgac gccctgaaca agtccctgta ttctttcttt     1200

aagggaggag gctccaaggg agcaggactg cctatccacg agtttggcaa ggcccagttc     1260

tacaggcgca ccgaggaggc catcctggat tccctggcca gactggactt ttctaatccc     1320

aggcctgtgc tgctggccct gcagaagaag ctggatacag aggtgagagg cctgttcgag     1380

gaggccgtga ggccatacct gaacgacccc aatctgatcc acaccatggc cgtgagccgg     1440

agaacactgt ataagaacct gaatgtgctg aagccacagc aggagggagg agtggacggc     1500

aagagaaact aa                                                         1512


<210>  92
<211>  480
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(480)
<223>  Cse2

<400>  92
atggccaagg agacagattt catggacctg taccaggcct ggcagagact gccaaacgga       60

ccaaaggcag agctgaagag gtgcggcgat ctgggcgacc tgctggagac cagcgccttt      120

tacagactgc tggcaggaag gggagaggca gagtggcaga agaaggccta tcagcggatg      180

atcttctgcc tgccctgtat caatcacaca gagcagaaga tccctctggg agccgccctg      240

gcacggagca gaaagggcag ccggagcgcc gtgagcgagt ctaggatgat ccaggtggtg      300

cgctccgagg caccaaacga tatggtgcag ctgaggcgca tcctgaagca cgcagagcca      360

accgtgaact ggcctctgat ggccaagcag ctgtggtact gggacctgaa tgagaggagc      420

aagcggagcc tgctggagga tttctttctg aaccacaccg acacaagcaa ggagggataa      480


<210>  93
<211>  1095
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(1095)
<223>  Cas7

<400>  93
atgcagaact ttatcaatta ccacgtgctg atctctcaca gcccatcctg cctgaaccgc       60

gacgatatga atatgcagaa gagcgccatc ttcggaggcg tgcggagagt gcggatcagc      120

tcccagagcc tgaagcgggc catgagaaag tccgactact atgcccagca cctgggcgag      180

gcctctatca gaaccaagca cctgagcggc ctgagggata ggctgcacga gcgcctggca      240

ggccggttca gccccgaagt gatcgacaag acaatcaagc tgctgatcga caaggatgtg      300

agcgtggatg gaatcgtgga gggcgacgca gtggcaccat gggcagtgga ggagtttgca      360

tggttctgtg agagagtgat gaacgcacag gcagagggcc tggaggataa ggccctgacc      420

aagcagctga aggagtccat cgccgccatg agacagacac tggtgggcgg cctggatatc      480

gccctgtctg gcaggatggc caccagcggc ctgctgtccg agctgggcaa ggtggacggc      540

gccctggcag tggcacacgc cctgaccaca cacaccgtgg acgccgatat cgactggttt      600

acagccgtgg acgatctgca ggagctgggc tctggccacc tggacaccca ggagttttct      660

agcggcgtgt tctacagata tgccagcctg aacatcggac agctgcagga gaatctggga      720

ggagcaccaa gggagcaggc cctggagatc gcaacccacg tgctgcagat gctggccaca      780

gtggtgccct ccgccaagca gcagtctttc gccgcccaca atctggccga tctggccctg      840

gtgtcctttg ccgacatccc cgtgagcctg gcaaacgcct tcgagaagcc agtgcagcag      900

aagaatggct ctggctttcg ggagccaagc atcgccgccc tgcacgacta ctggcagaag      960

gtgcacatcg gctatggcct ggaggagaga tgcggccagt tcgtgctgaa caaggtggag     1020

acccctgcag gaatcgcagc aaaggagtcc ctggaggatc tgaagtcttg ggtgcgcaac     1080

aatggagagg gataa                                                      1095


<210>  94
<211>  678
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(678)
<223>  Cas5

<400>  94
atgggcgact atctgatcct gaagctgcag ggacctatgc aggcctgggg agagcacagc       60

tttgagggaa cccgcccatc cggcaatttc cccacacggt ctgccctgct gggactgctg      120

ggagcatgtc tgggcatccg gcggaacgag tacgagaggc tgcagcagct ggccgatagc      180

gtgcagtttg ccgtgagaaa ggacgccagg cagacccaga cagagtgggg cgagccaaag      240

aagctgccca tggtgaagat gaccgattac cacacagtga aggacgccag acagtcttat      300

atcggcctga agagccacga gaccatccag acatggaggg agtacctgct ggacgccgag      360

tattctgtgg ccatctggga gaatgaggat gcagccgtga gcctggacga gctggagacc      420

gccgtgagga agcccgtgtt caccccatac ctgggcaggc gcagctgccc actggcacag      480

cctctgttcg gcaagcgcct gaccgcagag tccccaaacc aggccctgca ggcagtggag      540

ccttccggcg gcgtgatcta ttctgagcag ccctctgatc gcagcatgag gctgagggac      600

ctgcctatgg caggacagcc aaggcagttc gcatctcgga ccgtgtacat ccacggaggc      660

gatcacgtgt ccgagtaa                                                    678


<210>  95
<211>  609
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(609)
<223>  Cas6

<400>  95
atgtacctga gcaaagtgat ggtgaccgga gcagcatgta ggaacccata tgagatccac       60

cggtccctgt ggcagctgtt ccccgaggac cccgacgcac ggagagatta tctgttccgg      120

gtggagagag caggcaggca gcaggcagag atcctgctgc agagccagcg gaagccaagc      180

gactccgagc tgcgcaaggt gcggctgctg gcaaccagag gataccagcc aaggctgcag      240

cagggacagc ggctgagatt tgccctgctg gccaaccctg tgaagacaat caatgatgag      300

aggggccgcc tgaacgcaaa gggacaggtg aagaagtgca gggtgccact gatcagggag      360

gaggagtgga gaagctggct ggagcacaag ctgatcggat gtgcagagct ggagaccctg      420

gtggcagaga acaggctgcc catcaacttc agaaagccaa aggagaagag ggtgggcaag      480

atccagcccg tgagcttcca gggcatcctg agagtgtcct ctccagaggc catgatgcag      540

gccatctcta ccggcatcgg accagcaaag gccttcggct gcggactgct gagcatcgca      600

ccagcataa                                                              609


<210>  96
<211>  503
<212>  PRT
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(503)
<223>  Cas8

<400>  96

Met Asn Leu Leu Thr Asp Pro Trp Ile Pro Ala Arg Pro Gln Gly Arg 
1               5                   10                  15      


Ala Thr Ala Gln Lys Leu Thr Leu Arg Gln Leu Leu Cys Glu Asp Glu 
            20                  25                  30          


Arg Trp Glu Leu Arg Leu Pro Arg Asp Asp Met Glu Met Ala Thr Leu 
        35                  40                  45              


Gln Leu Leu Ile Cys Leu Thr Gln Ala Leu Ala Thr Pro Ala Asp Leu 
    50                  55                  60                  


Pro Glu Leu Lys Arg Arg Ile Met Lys Pro Leu Gly Gln Gln Glu Phe 
65                  70                  75                  80  


Asn Ala Ala Tyr Thr Pro Phe Ala Asp Trp Phe Arg Leu Asp His Pro 
                85                  90                  95      


Gln Tyr Pro Phe Met Gln Val Arg Gly Val Lys Ala Lys Glu Pro Thr 
            100                 105                 110         


Pro Met Asp Lys Leu Leu Ala Gly Leu Thr Gly Ala Thr Asn Ser Cys 
        115                 120                 125             


Phe Val Asn Gln Ser Gly Leu Gly Glu Gly Leu Cys Pro Ala Cys Ala 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Met Asn Val Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ala Ser Leu Arg Gly Ser Ala Pro Val Thr Thr Leu Val 
                165                 170                 175     


Gln Gly Glu His Leu Arg Gln Thr Ile Trp Leu Asn Val Leu Ser Thr 
            180                 185                 190         


Glu Ser Val Glu Ala Leu Leu Pro Trp His Arg Gln Thr Glu Asp Gln 
        195                 200                 205             


Lys Pro Thr Trp Ile Ala Pro Ile Lys Ser Glu Thr Phe Ser Ser Arg 
    210                 215                 220                 


Ser Ile Gly Phe Leu Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Leu Pro Ala Glu Ser Val Gly Asp Cys Ser Cys Cys Gly Gln Gly 
                245                 250                 255     


Asp Thr Glu Val Tyr Arg Gly Phe Asn Lys Ala Lys Phe Asn Tyr Thr 
            260                 265                 270         


Val Thr Gly Ile Trp Pro His Pro His Gly Ala Arg Thr Ser Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Gln Glu Glu Lys Phe Val Ser Phe Thr Thr Glu Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Leu Gly Arg Phe Val Ala Arg Arg Ala Phe Val 
305                 310                 315                 320 


Asp Ala Lys Thr Pro Gly Gln Glu Pro Ala Ala Val Ile Arg Gln Ala 
                325                 330                 335     


Gln Lys Leu Gly Val Arg Leu Thr Leu Cys Ile Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Glu Leu Leu Pro Leu Gly 
        355                 360                 365             


Glu Gly Trp Asn Ser Lys Pro Gln Ile Val Gln Asp Val Val Asp Thr 
    370                 375                 380                 


Ala Ile Gly Tyr Arg Asp Ala Leu Asn Lys Ser Leu Tyr Ser Phe Phe 
385                 390                 395                 400 


Lys Gly Gly Gly Ser Lys Gly Ala Gly Leu Pro Ile His Glu Phe Gly 
                405                 410                 415     


Lys Ala Gln Phe Tyr Arg Arg Thr Glu Glu Ala Ile Leu Asp Ser Leu 
            420                 425                 430         


Ala Arg Leu Asp Phe Ser Asn Pro Arg Pro Val Leu Leu Ala Leu Gln 
        435                 440                 445             


Lys Lys Leu Asp Thr Glu Val Arg Gly Leu Phe Glu Glu Ala Val Arg 
    450                 455                 460                 


Pro Tyr Leu Asn Asp Pro Asn Leu Ile His Thr Met Ala Val Ser Arg 
465                 470                 475                 480 


Arg Thr Leu Tyr Lys Asn Leu Asn Val Leu Lys Pro Gln Gln Glu Gly 
                485                 490                 495     


Gly Val Asp Gly Lys Arg Asn 
            500             


<210>  97
<211>  159
<212>  PRT
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(159)
<223>  Cse2

<400>  97

Met Ala Lys Glu Thr Asp Phe Met Asp Leu Tyr Gln Ala Trp Gln Arg 
1               5                   10                  15      


Leu Pro Asn Gly Pro Lys Ala Glu Leu Lys Arg Cys Gly Asp Leu Gly 
            20                  25                  30          


Asp Leu Leu Glu Thr Ser Ala Phe Tyr Arg Leu Leu Ala Gly Arg Gly 
        35                  40                  45              


Glu Ala Glu Trp Gln Lys Lys Ala Tyr Gln Arg Met Ile Phe Cys Leu 
    50                  55                  60                  


Pro Cys Ile Asn His Thr Glu Gln Lys Ile Pro Leu Gly Ala Ala Leu 
65                  70                  75                  80  


Ala Arg Ser Arg Lys Gly Ser Arg Ser Ala Val Ser Glu Ser Arg Met 
                85                  90                  95      


Ile Gln Val Val Arg Ser Glu Ala Pro Asn Asp Met Val Gln Leu Arg 
            100                 105                 110         


Arg Ile Leu Lys His Ala Glu Pro Thr Val Asn Trp Pro Leu Met Ala 
        115                 120                 125             


Lys Gln Leu Trp Tyr Trp Asp Leu Asn Glu Arg Ser Lys Arg Ser Leu 
    130                 135                 140                 


Leu Glu Asp Phe Phe Leu Asn His Thr Asp Thr Ser Lys Glu Gly 
145                 150                 155                 


<210>  98
<211>  364
<212>  PRT
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(364)
<223>  Cas7

<400>  98

Met Gln Asn Phe Ile Asn Tyr His Val Leu Ile Ser His Ser Pro Ser 
1               5                   10                  15      


Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Ser Ala Ile Phe Gly 
            20                  25                  30          


Gly Val Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met 
        35                  40                  45              


Arg Lys Ser Asp Tyr Tyr Ala Gln His Leu Gly Glu Ala Ser Ile Arg 
    50                  55                  60                  


Thr Lys His Leu Ser Gly Leu Arg Asp Arg Leu His Glu Arg Leu Ala 
65                  70                  75                  80  


Gly Arg Phe Ser Pro Glu Val Ile Asp Lys Thr Ile Lys Leu Leu Ile 
                85                  90                  95      


Asp Lys Asp Val Ser Val Asp Gly Ile Val Glu Gly Asp Ala Val Ala 
            100                 105                 110         


Pro Trp Ala Val Glu Glu Phe Ala Trp Phe Cys Glu Arg Val Met Asn 
        115                 120                 125             


Ala Gln Ala Glu Gly Leu Glu Asp Lys Ala Leu Thr Lys Gln Leu Lys 
    130                 135                 140                 


Glu Ser Ile Ala Ala Met Arg Gln Thr Leu Val Gly Gly Leu Asp Ile 
145                 150                 155                 160 


Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Leu Leu Ser Glu Leu Gly 
                165                 170                 175     


Lys Val Asp Gly Ala Leu Ala Val Ala His Ala Leu Thr Thr His Thr 
            180                 185                 190         


Val Asp Ala Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu 
        195                 200                 205             


Leu Gly Ser Gly His Leu Asp Thr Gln Glu Phe Ser Ser Gly Val Phe 
    210                 215                 220                 


Tyr Arg Tyr Ala Ser Leu Asn Ile Gly Gln Leu Gln Glu Asn Leu Gly 
225                 230                 235                 240 


Gly Ala Pro Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Leu Gln 
                245                 250                 255     


Met Leu Ala Thr Val Val Pro Ser Ala Lys Gln Gln Ser Phe Ala Ala 
            260                 265                 270         


His Asn Leu Ala Asp Leu Ala Leu Val Ser Phe Ala Asp Ile Pro Val 
        275                 280                 285             


Ser Leu Ala Asn Ala Phe Glu Lys Pro Val Gln Gln Lys Asn Gly Ser 
    290                 295                 300                 


Gly Phe Arg Glu Pro Ser Ile Ala Ala Leu His Asp Tyr Trp Gln Lys 
305                 310                 315                 320 


Val His Ile Gly Tyr Gly Leu Glu Glu Arg Cys Gly Gln Phe Val Leu 
                325                 330                 335     


Asn Lys Val Glu Thr Pro Ala Gly Ile Ala Ala Lys Glu Ser Leu Glu 
            340                 345                 350         


Asp Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Gly 
        355                 360                 


<210>  99
<211>  225
<212>  PRT
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(225)
<223>  Cas5

<400>  99

Met Gly Asp Tyr Leu Ile Leu Lys Leu Gln Gly Pro Met Gln Ala Trp 
1               5                   10                  15      


Gly Glu His Ser Phe Glu Gly Thr Arg Pro Ser Gly Asn Phe Pro Thr 
            20                  25                  30          


Arg Ser Ala Leu Leu Gly Leu Leu Gly Ala Cys Leu Gly Ile Arg Arg 
        35                  40                  45              


Asn Glu Tyr Glu Arg Leu Gln Gln Leu Ala Asp Ser Val Gln Phe Ala 
    50                  55                  60                  


Val Arg Lys Asp Ala Arg Gln Thr Gln Thr Glu Trp Gly Glu Pro Lys 
65                  70                  75                  80  


Lys Leu Pro Met Val Lys Met Thr Asp Tyr His Thr Val Lys Asp Ala 
                85                  90                  95      


Arg Gln Ser Tyr Ile Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp 
            100                 105                 110         


Arg Glu Tyr Leu Leu Asp Ala Glu Tyr Ser Val Ala Ile Trp Glu Asn 
        115                 120                 125             


Glu Asp Ala Ala Val Ser Leu Asp Glu Leu Glu Thr Ala Val Arg Lys 
    130                 135                 140                 


Pro Val Phe Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Ala Gln 
145                 150                 155                 160 


Pro Leu Phe Gly Lys Arg Leu Thr Ala Glu Ser Pro Asn Gln Ala Leu 
                165                 170                 175     


Gln Ala Val Glu Pro Ser Gly Gly Val Ile Tyr Ser Glu Gln Pro Ser 
            180                 185                 190         


Asp Arg Ser Met Arg Leu Arg Asp Leu Pro Met Ala Gly Gln Pro Arg 
        195                 200                 205             


Gln Phe Ala Ser Arg Thr Val Tyr Ile His Gly Gly Asp His Val Ser 
    210                 215                 220                 


Glu 
225 


<210>  100
<211>  202
<212>  PRT
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(202)
<223>  Cas6

<400>  100

Met Tyr Leu Ser Lys Val Met Val Thr Gly Ala Ala Cys Arg Asn Pro 
1               5                   10                  15      


Tyr Glu Ile His Arg Ser Leu Trp Gln Leu Phe Pro Glu Asp Pro Asp 
            20                  25                  30          


Ala Arg Arg Asp Tyr Leu Phe Arg Val Glu Arg Ala Gly Arg Gln Gln 
        35                  40                  45              


Ala Glu Ile Leu Leu Gln Ser Gln Arg Lys Pro Ser Asp Ser Glu Leu 
    50                  55                  60                  


Arg Lys Val Arg Leu Leu Ala Thr Arg Gly Tyr Gln Pro Arg Leu Gln 
65                  70                  75                  80  


Gln Gly Gln Arg Leu Arg Phe Ala Leu Leu Ala Asn Pro Val Lys Thr 
                85                  90                  95      


Ile Asn Asp Glu Arg Gly Arg Leu Asn Ala Lys Gly Gln Val Lys Lys 
            100                 105                 110         


Cys Arg Val Pro Leu Ile Arg Glu Glu Glu Trp Arg Ser Trp Leu Glu 
        115                 120                 125             


His Lys Leu Ile Gly Cys Ala Glu Leu Glu Thr Leu Val Ala Glu Asn 
    130                 135                 140                 


Arg Leu Pro Ile Asn Phe Arg Lys Pro Lys Glu Lys Arg Val Gly Lys 
145                 150                 155                 160 


Ile Gln Pro Val Ser Phe Gln Gly Ile Leu Arg Val Ser Ser Pro Glu 
                165                 170                 175     


Ala Met Met Gln Ala Ile Ser Thr Gly Ile Gly Pro Ala Lys Ala Phe 
            180                 185                 190         


Gly Cys Gly Leu Leu Ser Ile Ala Pro Ala 
        195                 200         


<210>  101
<211>  90
<212>  DNA
<213>  Geothermobacter sp. EPR-M


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  101
ctgttccccg cacccgcggg gatgaaccgg tcatctattt ttaatggacg atatttttca       60

actgttcccc gcacccgcgg ggatgaaccg                                        90


<210>  102
<211>  1509
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(1509)
<223>  Cas8

<400>  102
atgaatctgc ttgaagaccc ttggattccc gtgcgtgccg atggcggtac gggcgctttc       60

caactgctga cctatcggca gctactttgc gaacccggca actggcaggt gagcttgccg      120

cgtgacgatc tggagctggc ctgtgtgcaa ttgctggtgt gcatgactca ggtgatgttc      180

ttgccggaaa acgacgctgt ttggcggaag cggttgactg aagctttgac gcgtgaagag      240

ttcaccgccg gcacagaacc gtgcctggat tggttcgatc tcgaccaccc gacccagcct      300

ttcatgcaat cacgaggagt gagggccgcc gaggacacgc ccattcagaa gctgctgatt      360

ggcctgccgg aaggaaacaa ccacgctttc ttcaacgagg cgggcgaagt gcgccaccta      420

tcggtaacag tggcagcaat tgccctgttc aatcaggcta ctaattgccc cagtttcggc      480

ggcggcttca agggcagcct acgtggaggc gcgccaatca ccacactggt gaatggcgag      540

aatttgcgcg aaaccgtctg gtgtaatgta ctcacacgct cccgtttggc tgcgcgccag      600

atcgccatgc ccggattgga tcgggaccgt ccaacctggg tcgagcctat ccaggaaaaa      660

gccaccattc cctggaacac catcggtttg gcgcgaggct tgttttggca gccggcgcgg      720

gtggaactgg tgaggtccat ggccgctgca ccttgcgatg tgatgggcgg cgcgcccaca      780

ttgggatacg tgggatttcg caaggagaaa ttcaacttta ccgtggaggg agtgtggccc      840

caccctcatg gcgcaataac catgaccttg aaaaaaggcg cgcttgaaca aaagttcgcc      900

agcttcacga ccaccgcgcc ggcatggacc cagctctccg aattcgtcgt gcccaaaggc      960

gtcaatgatc ccggagccaa agagggctcc attcccgcag gaccggttac acaagccagc     1020

gagctaggcg aaagcggttt acacctgctc gttggcggct atcgcaccaa tcaagcttcc     1080

gtgttggaac ggcgccacga aatgatgagc ctggcccgag gctggcggga tgacaaaagc     1140

cgcctgccca aattggtcga aatgggcaaa gaggcaaaaa aagccttgcg cggcaagctc     1200

tatttcgccg ttcagggcaa taaagacaaa gggcttaaag gtattggcgc ggccatccac     1260

gaaaccgccg agaaactgtt ttacgcccga accgaaagtc tgatccacga aaccttttcc     1320

aatgaactca cgttcaagca gtgggccacc gcccgcaagg cttttgtcca ggaattggcc     1380

ggccattgcc gcgcaatttt tgaggagctg actgcacctt atgcgatgaa accggagttg     1440

attccggtta tcgcctgggc gcggcgcagc ctgaatttcg atcttaccaa gctgatggag     1500

gatgcatga                                                             1509


<210>  103
<211>  456
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(456)
<223>  Cse2

<400>  103
atgactgccg aattgccgga ttttgtcgcg ctgaaaatgc actacgacga cgagagcttt       60

ccgaccggcg cacgtgccga gctgcgccgt gctgccgaac cggatgatgt ggcgttgacc      120

ccggcgctct accgcttatt ccccggcgag cggccgagcg accgccactt acgtgtcgcc      180

tatctcctgc cctatgccaa acacgcggct aaagccaagt cgttgggtgc gcaactggcg      240

gaagccaagg tggcggaagc acgggttctg caagtggccc gcgctcatga accgctcgat      300

gtggtccagt tacgtcgcct cttgatgcag gttgaagccg cagtggactg gtcggcgttc      360

ggcccgatgg tgtggttttg gaacgaacga gccaaacgtc agctcatcga ggatttctat      420

atcgcccgtt tttcccccgt cacaggagct aaataa                                456


<210>  104
<211>  1137
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(1137)
<223>  Cas7

<400>  104
atgaccaaga agaacttcat caacttccat gtactcattt cccacagccc ctcctgtctc       60

aaccgggacg atatgaacat gcagaaaacc gccgtatttg gtggcgtcaa ccgggtgcgg      120

atttccagcc aatctctgaa gcgggcgata cgcaagagcg attactacca agccaatttg      180

ggcgcaccat cggtgcgcac ccgcgatttg aacaaactca aagcgcgttt caccgaactg      240

ctcaaagacc gctttgacgc cgaattgatt aaccgcgcgc tggagtggat ttccggcaag      300

gaaggtatcg ccgaaggcgt aacggccgac gccgttgcgc cctggtcggt ggatgaagta      360

acgcacttct gcgaaatcat tagcgccgac gaccagcaag atatcaagaa actggaaaag      420

cagattgaaa aagaggcgcg tcctttccgg gcggctatga gcaacaccgt ggacatcgcc      480

ttgtccggtc gtatggcgac cagtggattg atgagcaacc tgcccgtgga tggcgcgctc      540

gccgtcgctc acgccattac cacccatgcc gtcgagccgc aggacgtgga ctggttcacc      600

gccgtcgacg atttgaccca ggacgcgggc gatacgggag cgggacatct ggatacccag      660

cagttttcct ccggcgtgtt ctaccgttac gccagtctca acctgagaca actgcaagtg      720

aacctgggat tgatcgacca catcaaggcg gaggaaaccg ccgagtcccg ccaacgtgcg      780

ctggacatcg cccatcatgt attccattta ctggcgacgg tggtgccttc ggccaagcaa      840

cagtctttcg ccgctcacaa cttggcggac ttcgccatcg tcagcttcgc cgaccagccg      900

atttcgttag ccaatgcatt cgaagaaccg gtcagacgcg attacaaact ggcgggattc      960

ctcaaaccat ccattcagtg tttggccaat tactggggac gcatgaatcg cgcctacggt     1020

ctggacgaac aggcgcgcgc tttcgcggtc gatgcgagct tcgagatggg cggcaagcct     1080

cccctggact ccctgaaagc ggtggaagac tggatcgccg aggatggtca ggaataa        1137


<210>  105
<211>  681
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(681)
<223>  Cas5

<400>  105
atgccgcgtt atttgattct cctcctggac ggtcccatgc aagcgtgggg cacgcacacg       60

ttcgaagatt ttcgcccttg caatgcgttt ccgactcgca gcggtttgct cggactgcta      120

ggtgcctgcc tggggttgga ccggcgcgat accgaagcat tggagcaatt ggcgatgagc      180

gtcgagttcg ccgtacgcgc cgacagagag gtgttgcggc cggaagcgga agtacccaag      240

gcaaaagccg ctgtaaagct tcccgacttc cacacggtgg aggatgctcg caaggtagac      300

ggttccgcca acaagaaccc ggtggtttct cggcgcgaat acctgttcga tgccgctttc      360

accgtggcga tcggcgcaaa gcccgacggg ccggttacgc tggatgcaat tgccgaagct      420

ttgcggcgcc cgtgttttac gcctgtgctg ggacggcgtt cctgtcccat cgcccggcct      480

ttgctcgatg gcgaggccgt ggaggcgagc gatgcgaagg cggcactggc aaccatcgca      540

cctgtaggtg gcatgatcta taccgaaggc gaattgatct ccgcacaacc cttgcgggtc      600

cgcgacgtac ccatacaggg ccggcaccgg caattcagca ctcgactggt gtatctccat      660

aagggggaaa catgttcctg a                                                681


<210>  106
<211>  627
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(627)
<223>  Cas6

<400>  106
atgttcctga gccgtgtcga gattccttgg gatgcagtcc gcaaccctta cgaaattcat       60

cgccagcttt ggcggctgtt tcccggagag gacaaagaac cccggaagaa tgccgaggaa      120

ggacgccaag ggttcctgtt cagggtggaa aacaatcagc ctggccgccc gctgcgtttg      180

ttgattcagt ctcggcgagc gccagagcct acggctggat tgacgattgt aggtacgcgc      240

gaattccaac cccagccagc tcacgggcag cgcttggcat ttctactcac ctcaaatccg      300

gtcaaaacca ttatcgatgc acagcgagaa accaagtcgg gcaaaagctc cgaaaagtgc      360

cgtgtgccgt tgattcacga atccgaacag cgcgaatggt taaagcgcaa actcatcggt      420

gcgggagaat ttgaaggtgt caatgtggtg cctcacgccc cggtgttctt tcggaaaggc      480

aatcggggcg gcaagatagt catggtgact ttcgaaggcg tattgcgtgt aaacgagcca      540

ggaacgttga tcgcctattt ggaaaacggc atcggccccg ccaaagcctt cggttgcggt      600

ttgctgttag tacggcgctt gggataa                                          627


<210>  107
<211>  1509
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(1509)
<223>  Cas8

<400>  107
atgaatctgc tggaggaccc ttggattccc gtgcgggcag atggaggaac cggagcattc       60

cagctgctga catacaggca gctgctgtgc gagccaggaa actggcaggt gagcctgcca      120

agggacgatc tggagctggc ctgcgtgcag ctgctggtgt gcatgaccca ggtcatgttt      180

ctgcctgaga atgacgccgt gtggaggaag cgcctgaccg aggccctgac aagagaggag      240

ttcacagccg gcaccgagcc atgtctggac tggtttgacc tggatcaccc cacccagcct      300

ttcatgcagt ctaggggcgt gcgcgcagca gaggatacac caatccagaa gctgctgatc      360

ggcctgcctg agggcaacaa tcacgccttc tttaatgagg caggagaggt gcggcacctg      420

agcgtgaccg tggccgccat cgccctgttc aaccaggcca caaattgccc ttcctttggc      480

ggaggcttca agggctctct gaggggagga gcaccaatca ccacactggt caacggcgag      540

aatctgcggg agaccgtgtg gtgtaacgtg ctgacacggt ccagactggc agcaaggcag      600

atcgcaatgc caggcctgga cagggatagg cctacctggg tggagccaat ccaggagaag      660

gccaccatcc cctggaatac aatcggactg gcaaggggac tgttttggca gcctgcccgg      720

gtggagctgg tgagaagcat ggcagcagca ccttgcgacg tgatgggagg agcaccaacc      780

ctgggatatg tgggcttcag aaaggagaag tttaacttca cagtggaggg cgtgtggcca      840

cacccacacg gagccatcac aatgaccctg aagaagggcg ccctggagca gaagtttgcc      900

agcttcacca caaccgcacc tgcatggacc cagctgtccg agttcgtggt gccaaaggga      960

gtgaacgatc caggagcaaa ggagggctcc atcccagcag gaccagtgac ccaggcctcc     1020

gagctgggag agtctggcct gcacctgctg gtgggaggat acaggacaaa tcaggccagc     1080

gtgctggagc ggagacacga gatgatgtcc ctggcccggg gctggagaga cgataagagc     1140

cggctgccaa agctggtgga gatgggcaag gaggccaaga aggccctgag gggcaagctg     1200

tattttgccg tgcagggcaa caaggacaag ggcctgaagg gaatcggagc agcaatccac     1260

gagaccgccg agaagctgtt ctacgccaga acagagtctc tgatccacga gaccttcagc     1320

aatgagctga ccttcaagca gtgggccaca gccagaaagg cctttgtgca ggagctggca     1380

ggacactgta gggcaatctt cgaggagctg accgccccct acgccatgaa gcctgagctg     1440

atcccagtga tcgcatgggc aaggcgcagc ctgaacttcg acctgacaaa gctgatggag     1500

gatgcctaa                                                             1509


<210>  108
<211>  456
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(456)
<223>  Cse2

<400>  108
atgacagcag agctgccaga ttttgtggcc ctgaagatgc actatgacga tgagtccttc       60

cccaccggag caagggcaga gctgaggcgc gcagccgagc ctgacgatgt ggccctgaca      120

ccagccctgt acaggctgtt tcctggagag aggccatctg acaggcacct gcgcgtggca      180

tacctgctgc cctatgccaa gcacgccgcc aaggccaaga gcctgggagc acagctggca      240

gaggcaaagg tggccgaggc ccgggtgctg caggtggcca gagcacacga gcccctggac      300

gtggtgcagc tgcggagact gctgatgcag gtggaggcag cagtggattg gtccgccttt      360

ggccctatgg tgtggttctg gaacgagcgg gccaagagac agctgatcga ggacttttat      420

atcgcccgct tctctccagt gaccggagca aagtaa                                456


<210>  109
<211>  1137
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(1137)
<223>  Cas7

<400>  109
atgaccaaga agaactttat caatttccac gtgctgatca gccactcccc ttcttgcctg       60

aacagagacg atatgaatat gcagaagaca gccgtgttcg gcggcgtgaa tcgggtgaga      120

atcagctccc agtccctgaa gcgggccatc agaaagtctg actactatca ggccaacctg      180

ggagcaccaa gcgtgaggac ccgcgatctg aataagctga aggcccggtt tacagagctg      240

ctgaaggaca gattcgatgc cgagctgatc aacagggccc tggagtggat ctccggcaag      300

gagggcatcg cagagggagt gaccgcagac gcagtggccc catggtctgt ggatgaggtg      360

acacactttt gtgagatcat cagcgccgac gatcagcagg acatcaagaa gctggagaag      420

cagatcgaga aggaggcaag gcccttccgc gcagcaatga gcaacaccgt ggacatcgcc      480

ctgtccggca ggatggccac atctggcctg atgagcaatc tgccagtgga tggcgccctg      540

gcagtggcac acgcaatcac cacacacgcc gtggagcctc aggacgtgga ttggttcacc      600

gccgtggacg atctgacaca ggacgcaggc gataccggag caggacacct ggatacccag      660

cagttttcta gcggcgtgtt ctacagatat gcctccctga acctgcgcca gctgcaagtg      720

aatctgggcc tgatcgacca catcaaggca gaggagaccg cagagtctcg gcagagagcc      780

ctggatatcg cccaccacgt gtttcacctg ctggccacag tggtgccttc cgccaagcag      840

cagtctttcg ccgcccacaa cctggccgac tttgccatcg tgagcttcgc cgatcagcca      900

atctccctgg ccaatgcctt tgaggagccc gtgcggagag actacaagct ggccggcttc      960

ctgaagccat ccatccagtg cctggccaac tactggggcc ggatgaatag agcatatggc     1020

ctggacgagc aggcaagggc ctttgccgtg gatgccagct tcgagatggg cggcaagccc     1080

cctctggatt ccctgaaggc cgtggaggac tggatcgccg aggatggaca ggagtaa        1137


<210>  110
<211>  681
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(681)
<223>  Cas5

<400>  110
atgcctcggt acctgatcct gctgctggac ggaccaatgc aggcctgggg aacacacacc       60

tttgaggatt tcagaccctg caacgccttc cctaccagga gcggcctgct gggactgctg      120

ggagcctgtc tgggcctgga caggcgcgat acagaggccc tggagcagct ggccatgtcc      180

gtggagtttg ccgtgagggc agacagggag gtgctgaggc cagaggcaga ggtgccaaag      240

gcaaaggcag cagtgaagct gccagatttc cacaccgtgg aggacgcccg caaggtggat      300

ggctctgcca acaagaatcc cgtggtgagc cggagagagt atctgtttga cgcagccttc      360

accgtggcaa tcggagcaaa gcctgacgga ccagtgacac tggatgcaat cgcagaggcc      420

ctgaggcgcc cctgctttac ccctgtgctg ggccggagat cttgtccaat cgccagacca      480

ctgctggacg gagaggcagt ggaggccagc gatgccaagg ccgccctggc aaccatcgca      540

ccagtgggcg gcatgatcta tacagaggga gagctgatct ccgcccagcc actgagggtg      600

cgcgacgtgc ctatccaggg ccggcacaga cagttctcta cccgcctggt gtacctgcac      660

aagggcgaga catgcagcta a                                                681


<210>  111
<211>  627
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(627)
<223>  Cas6

<400>  111
atgtttctgt cccgcgtgga gatcccatgg gacgccgtgc ggaaccccta cgagatccac       60

aggcagctgt ggaggctgtt cccaggagag gataaggagc ctcgcaagaa tgccgaggag      120

ggcaggcagg gcttcctgtt tcgcgtggag aacaatcagc ccggccggcc tctgagactg      180

ctgatccaga gcaggagggc ccctgagcca acagcaggac tgaccatcgt gggcacaaga      240

gagtttcagc cacagcctgc acacggacag aggctggcct tcctgctgac atctaaccct      300

gtgaagacca tcatcgacgc ccagcgcgag accaagagcg gcaagtcctc tgagaagtgc      360

cgggtgccac tgatccacga gtccgagcag agggagtggc tgaagaggaa gctgatcgga      420

gcaggagagt tcgagggagt gaacgtggtg ccacacgcac ccgtgttctt tcggaagggc      480

aatagaggcg gcaagatcgt gatggtgacc tttgagggcg tgctgagggt gaacgagcca      540

ggcacactga tcgcctatct ggagaatggc atcggaccag caaaggcctt cggctgcgga      600

ctgctgctgg tgcggagact gggataa                                          627


<210>  112
<211>  502
<212>  PRT
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(502)
<223>  Cas8

<400>  112

Met Asn Leu Leu Glu Asp Pro Trp Ile Pro Val Arg Ala Asp Gly Gly 
1               5                   10                  15      


Thr Gly Ala Phe Gln Leu Leu Thr Tyr Arg Gln Leu Leu Cys Glu Pro 
            20                  25                  30          


Gly Asn Trp Gln Val Ser Leu Pro Arg Asp Asp Leu Glu Leu Ala Cys 
        35                  40                  45              


Val Gln Leu Leu Val Cys Met Thr Gln Val Met Phe Leu Pro Glu Asn 
    50                  55                  60                  


Asp Ala Val Trp Arg Lys Arg Leu Thr Glu Ala Leu Thr Arg Glu Glu 
65                  70                  75                  80  


Phe Thr Ala Gly Thr Glu Pro Cys Leu Asp Trp Phe Asp Leu Asp His 
                85                  90                  95      


Pro Thr Gln Pro Phe Met Gln Ser Arg Gly Val Arg Ala Ala Glu Asp 
            100                 105                 110         


Thr Pro Ile Gln Lys Leu Leu Ile Gly Leu Pro Glu Gly Asn Asn His 
        115                 120                 125             


Ala Phe Phe Asn Glu Ala Gly Glu Val Arg His Leu Ser Val Thr Val 
    130                 135                 140                 


Ala Ala Ile Ala Leu Phe Asn Gln Ala Thr Asn Cys Pro Ser Phe Gly 
145                 150                 155                 160 


Gly Gly Phe Lys Gly Ser Leu Arg Gly Gly Ala Pro Ile Thr Thr Leu 
                165                 170                 175     


Val Asn Gly Glu Asn Leu Arg Glu Thr Val Trp Cys Asn Val Leu Thr 
            180                 185                 190         


Arg Ser Arg Leu Ala Ala Arg Gln Ile Ala Met Pro Gly Leu Asp Arg 
        195                 200                 205             


Asp Arg Pro Thr Trp Val Glu Pro Ile Gln Glu Lys Ala Thr Ile Pro 
    210                 215                 220                 


Trp Asn Thr Ile Gly Leu Ala Arg Gly Leu Phe Trp Gln Pro Ala Arg 
225                 230                 235                 240 


Val Glu Leu Val Arg Ser Met Ala Ala Ala Pro Cys Asp Val Met Gly 
                245                 250                 255     


Gly Ala Pro Thr Leu Gly Tyr Val Gly Phe Arg Lys Glu Lys Phe Asn 
            260                 265                 270         


Phe Thr Val Glu Gly Val Trp Pro His Pro His Gly Ala Ile Thr Met 
        275                 280                 285             


Thr Leu Lys Lys Gly Ala Leu Glu Gln Lys Phe Ala Ser Phe Thr Thr 
    290                 295                 300                 


Thr Ala Pro Ala Trp Thr Gln Leu Ser Glu Phe Val Val Pro Lys Gly 
305                 310                 315                 320 


Val Asn Asp Pro Gly Ala Lys Glu Gly Ser Ile Pro Ala Gly Pro Val 
                325                 330                 335     


Thr Gln Ala Ser Glu Leu Gly Glu Ser Gly Leu His Leu Leu Val Gly 
            340                 345                 350         


Gly Tyr Arg Thr Asn Gln Ala Ser Val Leu Glu Arg Arg His Glu Met 
        355                 360                 365             


Met Ser Leu Ala Arg Gly Trp Arg Asp Asp Lys Ser Arg Leu Pro Lys 
    370                 375                 380                 


Leu Val Glu Met Gly Lys Glu Ala Lys Lys Ala Leu Arg Gly Lys Leu 
385                 390                 395                 400 


Tyr Phe Ala Val Gln Gly Asn Lys Asp Lys Gly Leu Lys Gly Ile Gly 
                405                 410                 415     


Ala Ala Ile His Glu Thr Ala Glu Lys Leu Phe Tyr Ala Arg Thr Glu 
            420                 425                 430         


Ser Leu Ile His Glu Thr Phe Ser Asn Glu Leu Thr Phe Lys Gln Trp 
        435                 440                 445             


Ala Thr Ala Arg Lys Ala Phe Val Gln Glu Leu Ala Gly His Cys Arg 
    450                 455                 460                 


Ala Ile Phe Glu Glu Leu Thr Ala Pro Tyr Ala Met Lys Pro Glu Leu 
465                 470                 475                 480 


Ile Pro Val Ile Ala Trp Ala Arg Arg Ser Leu Asn Phe Asp Leu Thr 
                485                 490                 495     


Lys Leu Met Glu Asp Ala 
            500         


<210>  113
<211>  151
<212>  PRT
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(151)
<223>  Cse2

<400>  113

Met Thr Ala Glu Leu Pro Asp Phe Val Ala Leu Lys Met His Tyr Asp 
1               5                   10                  15      


Asp Glu Ser Phe Pro Thr Gly Ala Arg Ala Glu Leu Arg Arg Ala Ala 
            20                  25                  30          


Glu Pro Asp Asp Val Ala Leu Thr Pro Ala Leu Tyr Arg Leu Phe Pro 
        35                  40                  45              


Gly Glu Arg Pro Ser Asp Arg His Leu Arg Val Ala Tyr Leu Leu Pro 
    50                  55                  60                  


Tyr Ala Lys His Ala Ala Lys Ala Lys Ser Leu Gly Ala Gln Leu Ala 
65                  70                  75                  80  


Glu Ala Lys Val Ala Glu Ala Arg Val Leu Gln Val Ala Arg Ala His 
                85                  90                  95      


Glu Pro Leu Asp Val Val Gln Leu Arg Arg Leu Leu Met Gln Val Glu 
            100                 105                 110         


Ala Ala Val Asp Trp Ser Ala Phe Gly Pro Met Val Trp Phe Trp Asn 
        115                 120                 125             


Glu Arg Ala Lys Arg Gln Leu Ile Glu Asp Phe Tyr Ile Ala Arg Phe 
    130                 135                 140                 


Ser Pro Val Thr Gly Ala Lys 
145                 150     


<210>  114
<211>  378
<212>  PRT
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(378)
<223>  Cas7

<400>  114

Met Thr Lys Lys Asn Phe Ile Asn Phe His Val Leu Ile Ser His Ser 
1               5                   10                  15      


Pro Ser Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Thr Ala Val 
            20                  25                  30          


Phe Gly Gly Val Asn Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg 
        35                  40                  45              


Ala Ile Arg Lys Ser Asp Tyr Tyr Gln Ala Asn Leu Gly Ala Pro Ser 
    50                  55                  60                  


Val Arg Thr Arg Asp Leu Asn Lys Leu Lys Ala Arg Phe Thr Glu Leu 
65                  70                  75                  80  


Leu Lys Asp Arg Phe Asp Ala Glu Leu Ile Asn Arg Ala Leu Glu Trp 
                85                  90                  95      


Ile Ser Gly Lys Glu Gly Ile Ala Glu Gly Val Thr Ala Asp Ala Val 
            100                 105                 110         


Ala Pro Trp Ser Val Asp Glu Val Thr His Phe Cys Glu Ile Ile Ser 
        115                 120                 125             


Ala Asp Asp Gln Gln Asp Ile Lys Lys Leu Glu Lys Gln Ile Glu Lys 
    130                 135                 140                 


Glu Ala Arg Pro Phe Arg Ala Ala Met Ser Asn Thr Val Asp Ile Ala 
145                 150                 155                 160 


Leu Ser Gly Arg Met Ala Thr Ser Gly Leu Met Ser Asn Leu Pro Val 
                165                 170                 175     


Asp Gly Ala Leu Ala Val Ala His Ala Ile Thr Thr His Ala Val Glu 
            180                 185                 190         


Pro Gln Asp Val Asp Trp Phe Thr Ala Val Asp Asp Leu Thr Gln Asp 
        195                 200                 205             


Ala Gly Asp Thr Gly Ala Gly His Leu Asp Thr Gln Gln Phe Ser Ser 
    210                 215                 220                 


Gly Val Phe Tyr Arg Tyr Ala Ser Leu Asn Leu Arg Gln Leu Gln Val 
225                 230                 235                 240 


Asn Leu Gly Leu Ile Asp His Ile Lys Ala Glu Glu Thr Ala Glu Ser 
                245                 250                 255     


Arg Gln Arg Ala Leu Asp Ile Ala His His Val Phe His Leu Leu Ala 
            260                 265                 270         


Thr Val Val Pro Ser Ala Lys Gln Gln Ser Phe Ala Ala His Asn Leu 
        275                 280                 285             


Ala Asp Phe Ala Ile Val Ser Phe Ala Asp Gln Pro Ile Ser Leu Ala 
    290                 295                 300                 


Asn Ala Phe Glu Glu Pro Val Arg Arg Asp Tyr Lys Leu Ala Gly Phe 
305                 310                 315                 320 


Leu Lys Pro Ser Ile Gln Cys Leu Ala Asn Tyr Trp Gly Arg Met Asn 
                325                 330                 335     


Arg Ala Tyr Gly Leu Asp Glu Gln Ala Arg Ala Phe Ala Val Asp Ala 
            340                 345                 350         


Ser Phe Glu Met Gly Gly Lys Pro Pro Leu Asp Ser Leu Lys Ala Val 
        355                 360                 365             


Glu Asp Trp Ile Ala Glu Asp Gly Gln Glu 
    370                 375             


<210>  115
<211>  226
<212>  PRT
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(226)
<223>  Cas5

<400>  115

Met Pro Arg Tyr Leu Ile Leu Leu Leu Asp Gly Pro Met Gln Ala Trp 
1               5                   10                  15      


Gly Thr His Thr Phe Glu Asp Phe Arg Pro Cys Asn Ala Phe Pro Thr 
            20                  25                  30          


Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu Gly Leu Asp Arg 
        35                  40                  45              


Arg Asp Thr Glu Ala Leu Glu Gln Leu Ala Met Ser Val Glu Phe Ala 
    50                  55                  60                  


Val Arg Ala Asp Arg Glu Val Leu Arg Pro Glu Ala Glu Val Pro Lys 
65                  70                  75                  80  


Ala Lys Ala Ala Val Lys Leu Pro Asp Phe His Thr Val Glu Asp Ala 
                85                  90                  95      


Arg Lys Val Asp Gly Ser Ala Asn Lys Asn Pro Val Val Ser Arg Arg 
            100                 105                 110         


Glu Tyr Leu Phe Asp Ala Ala Phe Thr Val Ala Ile Gly Ala Lys Pro 
        115                 120                 125             


Asp Gly Pro Val Thr Leu Asp Ala Ile Ala Glu Ala Leu Arg Arg Pro 
    130                 135                 140                 


Cys Phe Thr Pro Val Leu Gly Arg Arg Ser Cys Pro Ile Ala Arg Pro 
145                 150                 155                 160 


Leu Leu Asp Gly Glu Ala Val Glu Ala Ser Asp Ala Lys Ala Ala Leu 
                165                 170                 175     


Ala Thr Ile Ala Pro Val Gly Gly Met Ile Tyr Thr Glu Gly Glu Leu 
            180                 185                 190         


Ile Ser Ala Gln Pro Leu Arg Val Arg Asp Val Pro Ile Gln Gly Arg 
        195                 200                 205             


His Arg Gln Phe Ser Thr Arg Leu Val Tyr Leu His Lys Gly Glu Thr 
    210                 215                 220                 


Cys Ser 
225     


<210>  116
<211>  208
<212>  PRT
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(208)
<223>  Cas6

<400>  116

Met Phe Leu Ser Arg Val Glu Ile Pro Trp Asp Ala Val Arg Asn Pro 
1               5                   10                  15      


Tyr Glu Ile His Arg Gln Leu Trp Arg Leu Phe Pro Gly Glu Asp Lys 
            20                  25                  30          


Glu Pro Arg Lys Asn Ala Glu Glu Gly Arg Gln Gly Phe Leu Phe Arg 
        35                  40                  45              


Val Glu Asn Asn Gln Pro Gly Arg Pro Leu Arg Leu Leu Ile Gln Ser 
    50                  55                  60                  


Arg Arg Ala Pro Glu Pro Thr Ala Gly Leu Thr Ile Val Gly Thr Arg 
65                  70                  75                  80  


Glu Phe Gln Pro Gln Pro Ala His Gly Gln Arg Leu Ala Phe Leu Leu 
                85                  90                  95      


Thr Ser Asn Pro Val Lys Thr Ile Ile Asp Ala Gln Arg Glu Thr Lys 
            100                 105                 110         


Ser Gly Lys Ser Ser Glu Lys Cys Arg Val Pro Leu Ile His Glu Ser 
        115                 120                 125             


Glu Gln Arg Glu Trp Leu Lys Arg Lys Leu Ile Gly Ala Gly Glu Phe 
    130                 135                 140                 


Glu Gly Val Asn Val Val Pro His Ala Pro Val Phe Phe Arg Lys Gly 
145                 150                 155                 160 


Asn Arg Gly Gly Lys Ile Val Met Val Thr Phe Glu Gly Val Leu Arg 
                165                 170                 175     


Val Asn Glu Pro Gly Thr Leu Ile Ala Tyr Leu Glu Asn Gly Ile Gly 
            180                 185                 190         


Pro Ala Lys Ala Phe Gly Cys Gly Leu Leu Leu Val Arg Arg Leu Gly 
        195                 200                 205             


<210>  117
<211>  90
<212>  DNA
<213>  Methylocaldum sp. 14B


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  117
ctgttcccca cgtacgtggg gatgaaccga cggcgtaatg gtaattgtta gccgacaagt       60

tctgttcccc acgtacgtgg ggatgaaccg                                        90


<210>  118
<211>  1632
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(1632)
<223>  Cas8

<400>  118
ttgaaaaatc gagtgaaaag aggtgaacat ttggtctcat ataacttgtt aacagaaccg       60

tggatcacat ccatcgacct gtccggaaac ccggtgcagg agggaatact ggcgactttg      120

aaaaacgcac ataagatcga cagtattttt gatccggctc ctccggtaga attcggaata      180

taccgcctgc tgatcgcttt tataacagat gtcttccagc ctcagggact ggaggatctg      240

gccgatctcc tcgaccgtaa gcggttagac cccacagcgc tggacgaata tgccgccagg      300

tggagagacc ggtttgatct gttcgacgaa aaatacccgt tcttacagca ggcaataacg      360

ggggtaataa agaaacctcc cgagccgatc tccaggttga tgcagcatct gccggcaggc      420

actaacgtct cccattttca ccatggacgc tgggatgaga actccttctc tttcgagcag      480

tgcgccaaag ggctggtgac tatagccccg ttcatgacag ccggcggcgc tggcctgtcc      540

ccaagcatta acggcagccc accttggtac gttcttgtaa aaggcaacaa cctgttcgag      600

actctcctct acaacgtctg ccagatacca atgactgtca aacctatcgg agattcacct      660

gtagcctgga ggaacgacaa acgaatcgat cccggcgatg aacctaaaac cttttccatc      720

gtcgaaggtc tgacctggag gcccaggatc attcagctta tcccgggaaa cggcaagggc      780

acatgcacgt atactggaga aaaagacgtt gacacggtca gccacatgca ttattacccg      840

ggacaaaaat cgcccgagcc aggcctgtgg gtcgatcctc aggtagcata taaaaagact      900

aaggatgcca tcaggccgct caggccggac gagaacaagg cgctgtggcg agacattggg      960

ccgttgatgc tcctgcaaca cggggactac tcgggcaaag acggaaaagt aagcttcgat     1020

cggccggcgg tagttactca gtacaaacag atggtcagca atggtatgat caaacgcagc     1080

gagcctttaa gactggaagt ttatggtatc cgcacagatg gaaaaatgaa gatttacgaa     1140

tggtaccatg aaaaactagc tcttcccata gaaatcttga aaaaggcaaa ctccggccga     1200

caaatacagg acgcgatgga cctcgcagat agcgtagctt acatactccg gaaagccatg     1260

aaaaaagcct acccgagaaa tgcaaaatct aacgagagtg gattcgacaa tctcattctg     1320

agcgttcagt cttcctactg gagccatctg aaaggccagt tcgaaagcat tttcttaaaa     1380

acgctgtctc aacaggacga aaatgatctc gacgcataca ctaagctcat ggaacagtgg     1440

aagaaaatac tggacgatac tggaaagaac gcgctcgata aaggcctcgg accgctggat     1500

actgacggcg attcgctacg ccgccaggtc aaggcgatga acgagtacag ttcaggcatc     1560

agatttgcgc tgtaccctga ttccatacag gcgaagaaaa agaatcgaca gaaaaataag     1620

gaggataaat ga                                                         1632


<210>  119
<211>  591
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(591)
<223>  Cse2

<400>  119
atgaccgctc ccaacgaaaa caaagagcac cagaagagta aaaaggatga ggagttcctg       60

gcgaacttag caaagatggc cgaatccgat cgtggcggta tggccatcct gaagcgaaac      120

gccggcaaca cgatagcaga gtctcgcggc gcgatgaaaa ctttctatag cctgctacct      180

tacggcattt cagattcccc ctacgaggag atctacttcc tgatagccac tctgtacggg      240

cataataagt accgatttac aggggacttc ggacagacga tgaagcttgt aagagagagc      300

tcaaactcgg aaagcatcga ccagagagtg tcaactctgc tcgacagcga gttcaacatc      360

gtcgacggga taaaacccgg cgggggagaa ctcgcctatc ggctgcggca atgcgtgaaa      420

ctggccagcg gccacgagat cggggtagac tggtacaggc tcctgcagga cctgaaatac      480

tggggctacc cggaaaagag agtacagaag agatgggcca gatcatattt cggctacgga      540

aagccggtag aatctgaaac taaagagtca aaagaggagg caaaagcatg a               591


<210>  120
<211>  1176
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(1176)
<223>  Cas7

<400>  120
atgaaattaa tcgagataca catgatccag aaccacgctc cctgcaatct gaacagggat       60

gacacaggaa gcccgaaaga ctgcatgttc ggcggcatca ggcgatcgag gatatccagc      120

cagagcatca agcgcagcat caggatgtcc ccgatattca aggaagagat gaagggaatc      180

gaactggcga acaggacacg caggcttcct gaactcgtca aggccaagct catcagtgat      240

ggaatagacg aaaagatggc ggccatagcg gcagaaaagg ccaccggttt cggaaccaag      300

gacggtaaag aacgcgagga agacctgaac acggcccaga caatgttcat aacccagtct      360

gacgtcgacg ctgtagcatc ggtcatgaag gatgccatcc tgaaagccgg aaaccctaag      420

gcattcaagg acatgaaagc cgccgatctt caaaaagccg cagaactcaa gggatggcgg      480

cctgtaacac cggacctggc ccttttcggc cggatgatca catcggatgc attcatggac      540

atcgaggcat ccatgcaggt ggcccatgcg atctccacga acaaaatgga ccacgagttt      600

gattacttca ctgccgtgga tgaccttcag aagtcttccg acggccccgg agcagatatg      660

atcggcgacg tccagttcaa ctctgcctgc tactacaagt acttctcact ggattacgat      720

gccctgatac agaatctcgc aggcttgaaa cccggagata atgccacgga agccgataaa      780

aaagcctatg ctgaatcgct ggaaaacgcg aaaaaagtcg ccgcgatcac tatcaccgcc      840

tttctaaaag cggccatcta cacgacgccc agtggaaagc agaacagctt cgccgcgcat      900

cagctcccca gcgccgtcct tgtggaaatt cggccaacaa agacgccagt aagctacgct      960

aacgcgttcg ttgatccggc ccgcccgaga aacggtgtcg acatggtgga agataccctg     1020

aacaaattcg tgaaacatgt cgagctccag actgagaagt tcaacctgag atcgaccagg     1080

cggctctggt tcgttgcggg cgataaggcg ctcgccggaa cggaaacctg ccagacgatc     1140

aacgatctaa tatccggtat aaacagtgcc ctctaa                               1176


<210>  121
<211>  684
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(684)
<223>  Cas5

<400>  121
atggacaacc cattgctcct gctgttgagg ctggaggggc caatgcagtc atgggggctg       60

aaagccaggt gggatatcag agataccggg gacgagccta ccaagtccgg catcatcgga      120

ctgctcggct gcgctctcgg atatgcccga aaggacccgc ggctgactga cgaactggac      180

tcacaacttc ggataggcat tcgtgtggag tgccccggcg aaatcgccag ggattaccac      240

acggtcagcg gagagcttcg gaccgccgaa ggtaagctcc gcgaaacgac gattgtatcc      300

ttcagagact atctccagga tgcagcgttc ctcgtagtac tcgaaggccc gggagaactg      360

cttaccagaa taagcaacgc tctgaaagac cctgtatggc caatctatct gggaagaaaa      420

tcctgcccac cgacccgccc cgtcttcgaa accctgacca ctgactatgc ttcgatagac      480

gatgcactga gccgacaccc gtggagttcc gggactatgg aagcccgcaa agcgcacccc      540

aaagaattaa aatgtatagt cgaagacctc tccggacctt accagaggac tgatcggatg      600

acgaaaagcc cggccagaat gtacggcatc aggcacgtcc ggatgagcac tgtaaaactt      660

caagcagaag gagagggcct ttaa                                             684


<210>  122
<211>  753
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(753)
<223>  Cas6

<400>  122
atgtatttat caagactgat cctgaacccg agaacaaggg ctgtcagaag agacctcgct       60

gactgccacg aacttcatcg gactattctg gggggctttc cggaccttaa tggaaaagga      120

ggcgaagcaa gggaaacctt cggcgttctc caccggatcg acatccaccc cagaagcggc      180

gcgatcgtac tactggtcca gtcgcaggaa aagcccgact ggtcaaagct gccagaaggc      240

tatctactcg aaaatacggg cacggaaaat ccagcctgta aggctataga cgaacagtac      300

gggaaaataa aggccggcga tgtctatgct ttccgtcttc gagccaatcc tacgaaaaag      360

atcggcacgt cccggattga ggacatcaaa gccggcaagc ctaaaaataa cgggcggcgg      420

gtgccgatca gaaacgagag cgaccagatc ctctggctga aaagaaaagg cgcggcagga      480

ggcttcgaac tcatgtccac gaagaggttt agcgaactct ccgatgtgct catcagtgaa      540

gaaggccatc agaaaatata caccttcgac actggaataa aagcaaaagt ccagaaaaac      600

gcccgggaaa atagattaac cttcggctcg gtccttttcg aaggcaccct gaaagtgaca      660

aatgcagaaa agttcctcga aaccctcaaa tccggcatcg gcagcggcaa agcctatggc      720

ttcggcctcc tatccttagc tccggcaagg tga                                   753


<210>  123
<211>  1632
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(1632)
<223>  Cas8

<400>  123
atgaagaatc gcgtgaagcg gggcgagcac ctggtgtctt ataacctgct gacagagcct       60

tggatcacct ctatcgatct gagcggcaat ccagtgcagg agggcatcct ggccaccctg      120

aagaacgccc acaagatcga tagcatcttt gaccctgccc ctccagtgga gttcggcatc      180

tacaggctgc tgatcgcctt tatcaccgac gtgttccagc cacagggcct ggaggacctg      240

gcagatctgc tggacaggaa gcggctggac cccacagccc tggacgagta cgcagcacgg      300

tggagagata ggtttgacct gttcgatgag aagtatccat tcctgcagca ggccatcacc      360

ggcgtgatca agaagccccc tgagcccatc tctcgcctga tgcagcacct gcctgccggc      420

acaaatgtga gccactttca ccacggccgg tgggacgaga actcttttag cttcgagcag      480

tgcgccaagg gcctggtgac aatcgcaccc ttcatgaccg caggaggagc aggcctgtcc      540

ccttctatca acggcagccc accctggtac gtgctggtga agggcaacaa tctgtttgag      600

acactgctgt ataacgtgtg ccagatcccc atgaccgtga agcctatcgg cgatagccca      660

gtggcctgga gaaacgacaa gaggatcgac cctggcgatg agccaaagac attctccatc      720

gtggagggac tgacctggag gcctcggatc atccagctga tcccaggcaa tggcaagggc      780

acctgtacat ataccggcga gaaggacgtg gataccgtgt cccacatgca ctactatcca      840

ggccagaagt ctcctgagcc aggactgtgg gtggaccccc aggtggcata caagaagaca      900

aaggatgcca tcagacccct gaggcctgac gagaataagg ccctgtggcg cgatatcgga      960

ccactgatgc tgctgcagca cggcgattac tctggcaagg acggcaaggt gagcttcgat     1020

cggccagccg tggtgaccca gtataagcag atggtgtcca acggcatgat caagcggagc     1080

gagccactgc ggctggaggt gtacggcatc cgcacagacg gcaagatgaa gatctacgag     1140

tggtatcacg agaagctggc cctgcccatc gagatcctga agaaggccaa ttccggccgg     1200

cagatccagg acgccatgga tctggccgac tctgtggcct acatcctgag aaaggccatg     1260

aagaaggcct atcctaggaa cgccaagtcc aatgagtctg gctttgacaa cctgatcctg     1320

agcgtgcagt ctagctattg gtcccacctg aagggccagt ttgagtctat cttcctgaag     1380

acactgagcc agcaggatga gaatgacctg gatgcctaca ccaagctgat ggagcagtgg     1440

aagaagatcc tggacgatac aggcaagaac gccctggaca agggactggg acccctggac     1500

accgatggcg actccctgcg gagacaggtg aaggccatga acgagtactc ctctggcatc     1560

agattcgccc tgtatcctga ctctatccag gccaagaaga agaacaggca gaagaataag     1620

gaggataagt aa                                                         1632


<210>  124
<211>  591
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(591)
<223>  Cse2

<400>  124
atgacagccc caaacgagaa taaggagcac cagaagagca agaaggacga ggagttcctg       60

gccaacctgg caaagatggc agagagcgat aggggaggaa tggccatcct gaagcggaac      120

gccggcaata caatcgccga gagccggggc gccatgaaga ccttttacag cctgctgcca      180

tatggcatca gcgactcccc ctacgaggag atctatttcc tgatcgccac cctgtacggc      240

cacaacaagt ataggtttac aggcgacttc ggccagacca tgaagctggt gcgcgagtcc      300

tctaattctg agagcatcga tcagcgggtg agcacactgc tggattccga gtttaacatc      360

gtggacggca tcaagccagg aggaggagag ctggcataca ggctgaggca gtgcgtgaag      420

ctggcaagcg gccacgagat cggagtggat tggtatagac tgctgcagga cctgaagtac      480

tggggctatc cagagaagag ggtgcagaag cggtgggccc ggtcctactt cggctatggc      540

aagcccgtgg agtctgagac caaggagagc aaggaggagg caaaggcata a               591


<210>  125
<211>  1176
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(1176)
<223>  Cas7

<400>  125
atgaagctga tcgagatcca catgatccag aaccacgccc cctgcaacct gaatagagac       60

gataccggca gccctaagga ctgtatgttt ggaggcatcc ggcggagccg gatcagctcc      120

cagagcatca agagatccat caggatgtct cctatcttca aggaggagat gaagggcatc      180

gagctggcca atcgcacaag gcgcctgcca gagctggtga aggccaagct gatctccgat      240

ggcatcgacg agaagatggc agcaatcgca gcagagaagg caacaggctt tggcaccaag      300

gatggcaagg agcgggagga ggacctgaat acagcccaga ccatgttcat cacccagtcc      360

gacgtggatg ccgtggcctc tgtgatgaag gatgccatcc tgaaggccgg caaccccaag      420

gccttcaagg atatgaaggc agcagacctg cagaaggcag cagagctgaa gggatggaga      480

ccagtgacac ctgacctggc cctgtttggc aggatgatca ccagcgatgc cttcatggac      540

atcgaggcct ccatgcaggt ggcccacgcc atctctacaa ataagatgga tcacgagttt      600

gactacttca ccgccgtgga cgatctgcag aagtctagcg acggacctgg agcagatatg      660

atcggcgacg tgcagtttaa cagcgcctgc tactataagt acttctccct ggactatgat      720

gccctgatcc agaacctggc cggcctgaag ccaggcgata atgccaccga ggccgacaag      780

aaggcctatg ccgagtccct ggagaatgcc aagaaggtgg ccgccatcac catcacagcc      840

tttctgaagg ccgccatcta caccacacca tccggcaagc agaactcttt cgccgcacac      900

cagctgccaa gcgccgtgct ggtggagatc aggccaacca agacacccgt gtcctacgca      960

aacgccttcg tggaccccgc aaggccccgc aatggcgtgg atatggtgga ggacaccctg     1020

aacaagttcg tgaagcacgt ggagctgcag acagagaagt ttaacctgcg gagcacccgg     1080

agactgtggt tcgtggcagg cgacaaggcc ctggcaggaa ccgagacatg ccagacaatc     1140

aacgatctga tcagcggcat caattccgcc ctgtaa                               1176


<210>  126
<211>  684
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(684)
<223>  Cas5

<400>  126
atggataacc cactgctgct gctgctgcgg ctggagggac caatgcagag ctggggcctg       60

aaggcaagat gggatatcag ggacacaggc gatgagccca ccaagagcgg catcatcgga      120

ctgctgggat gcgcactggg atacgccaga aaggacccca ggctgaccga cgagctggat      180

tcccagctgc gcatcggcat ccgggtggag tgtcctggcg agatcgccag ggactatcac      240

acagtgagcg gcgagctgcg caccgcagag ggcaagctgc gggagaccac aatcgtgtcc      300

tttagagatt acctgcagga cgcagccttc ctggtggtgc tggagggacc aggagagctg      360

ctgaccagga tctccaacgc cctgaaggac cccgtgtggc caatctacct gggcagaaag      420

tcttgccctc caacaaggcc cgtgttcgag accctgacca cagactatgc ctccatcgac      480

gatgccctga gccggcaccc ttggagctcc ggcaccatgg aggcaaggaa ggcacaccca      540

aaggagctga agtgtatcgt ggaggacctg tctggcccat accagagaac agataggatg      600

accaagagcc ccgccagaat gtatggcatc cgccacgtgc ggatgagcac cgtgaagctg      660

caggcagagg gagagggact gtaa                                             684


<210>  127
<211>  753
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(753)
<223>  Cas6

<400>  127
atgtacctgt ctcggctgat cctgaaccct aggacccgcg ccgtgaggcg cgacctggca       60

gattgtcacg agctgcaccg cacaatcctg ggcggctttc cagacctgaa cggcaaggga      120

ggagaggcaa gggagacctt cggcgtgctg cacagaatcg atatccaccc aaggagcggc      180

gcaatcgtgc tgctggtgca gagccaggag aagcccgact ggtccaagct gcctgagggc      240

tacctgctgg agaacaccgg cacagagaat cctgcctgca aggccatcga cgagcagtac      300

ggcaagatca aggcaggcga cgtgtacgcc ttccggctga gagccaatcc aacaaagaag      360

atcggcacca gccggatcga ggatatcaag gccggcaagc ccaagaacaa tggccggaga      420

gtgcctatcc gcaacgagag cgaccagatc ctgtggctga agaggaaggg agcagcagga      480

ggatttgagc tgatgagcac caagaggttc agcgagctgt ccgacgtgct gatctccgag      540

gagggccacc agaagatcta tacattcgat accggcatca aggccaaggt gcagaagaac      600

gccagagaga ataggctgac ctttggcagc gtgctgttcg agggcacact gaaggtgacc      660

aatgccgaga agtttctgga gacactgaag agcggcatcg gctccggcaa ggcctacgga      720

ttcggactgc tgtccctggc acctgcaagg taa                                   753


<210>  128
<211>  543
<212>  PRT
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(543)
<223>  Cas8

<400>  128

Met Lys Asn Arg Val Lys Arg Gly Glu His Leu Val Ser Tyr Asn Leu 
1               5                   10                  15      


Leu Thr Glu Pro Trp Ile Thr Ser Ile Asp Leu Ser Gly Asn Pro Val 
            20                  25                  30          


Gln Glu Gly Ile Leu Ala Thr Leu Lys Asn Ala His Lys Ile Asp Ser 
        35                  40                  45              


Ile Phe Asp Pro Ala Pro Pro Val Glu Phe Gly Ile Tyr Arg Leu Leu 
    50                  55                  60                  


Ile Ala Phe Ile Thr Asp Val Phe Gln Pro Gln Gly Leu Glu Asp Leu 
65                  70                  75                  80  


Ala Asp Leu Leu Asp Arg Lys Arg Leu Asp Pro Thr Ala Leu Asp Glu 
                85                  90                  95      


Tyr Ala Ala Arg Trp Arg Asp Arg Phe Asp Leu Phe Asp Glu Lys Tyr 
            100                 105                 110         


Pro Phe Leu Gln Gln Ala Ile Thr Gly Val Ile Lys Lys Pro Pro Glu 
        115                 120                 125             


Pro Ile Ser Arg Leu Met Gln His Leu Pro Ala Gly Thr Asn Val Ser 
    130                 135                 140                 


His Phe His His Gly Arg Trp Asp Glu Asn Ser Phe Ser Phe Glu Gln 
145                 150                 155                 160 


Cys Ala Lys Gly Leu Val Thr Ile Ala Pro Phe Met Thr Ala Gly Gly 
                165                 170                 175     


Ala Gly Leu Ser Pro Ser Ile Asn Gly Ser Pro Pro Trp Tyr Val Leu 
            180                 185                 190         


Val Lys Gly Asn Asn Leu Phe Glu Thr Leu Leu Tyr Asn Val Cys Gln 
        195                 200                 205             


Ile Pro Met Thr Val Lys Pro Ile Gly Asp Ser Pro Val Ala Trp Arg 
    210                 215                 220                 


Asn Asp Lys Arg Ile Asp Pro Gly Asp Glu Pro Lys Thr Phe Ser Ile 
225                 230                 235                 240 


Val Glu Gly Leu Thr Trp Arg Pro Arg Ile Ile Gln Leu Ile Pro Gly 
                245                 250                 255     


Asn Gly Lys Gly Thr Cys Thr Tyr Thr Gly Glu Lys Asp Val Asp Thr 
            260                 265                 270         


Val Ser His Met His Tyr Tyr Pro Gly Gln Lys Ser Pro Glu Pro Gly 
        275                 280                 285             


Leu Trp Val Asp Pro Gln Val Ala Tyr Lys Lys Thr Lys Asp Ala Ile 
    290                 295                 300                 


Arg Pro Leu Arg Pro Asp Glu Asn Lys Ala Leu Trp Arg Asp Ile Gly 
305                 310                 315                 320 


Pro Leu Met Leu Leu Gln His Gly Asp Tyr Ser Gly Lys Asp Gly Lys 
                325                 330                 335     


Val Ser Phe Asp Arg Pro Ala Val Val Thr Gln Tyr Lys Gln Met Val 
            340                 345                 350         


Ser Asn Gly Met Ile Lys Arg Ser Glu Pro Leu Arg Leu Glu Val Tyr 
        355                 360                 365             


Gly Ile Arg Thr Asp Gly Lys Met Lys Ile Tyr Glu Trp Tyr His Glu 
    370                 375                 380                 


Lys Leu Ala Leu Pro Ile Glu Ile Leu Lys Lys Ala Asn Ser Gly Arg 
385                 390                 395                 400 


Gln Ile Gln Asp Ala Met Asp Leu Ala Asp Ser Val Ala Tyr Ile Leu 
                405                 410                 415     


Arg Lys Ala Met Lys Lys Ala Tyr Pro Arg Asn Ala Lys Ser Asn Glu 
            420                 425                 430         


Ser Gly Phe Asp Asn Leu Ile Leu Ser Val Gln Ser Ser Tyr Trp Ser 
        435                 440                 445             


His Leu Lys Gly Gln Phe Glu Ser Ile Phe Leu Lys Thr Leu Ser Gln 
    450                 455                 460                 


Gln Asp Glu Asn Asp Leu Asp Ala Tyr Thr Lys Leu Met Glu Gln Trp 
465                 470                 475                 480 


Lys Lys Ile Leu Asp Asp Thr Gly Lys Asn Ala Leu Asp Lys Gly Leu 
                485                 490                 495     


Gly Pro Leu Asp Thr Asp Gly Asp Ser Leu Arg Arg Gln Val Lys Ala 
            500                 505                 510         


Met Asn Glu Tyr Ser Ser Gly Ile Arg Phe Ala Leu Tyr Pro Asp Ser 
        515                 520                 525             


Ile Gln Ala Lys Lys Lys Asn Arg Gln Lys Asn Lys Glu Asp Lys 
    530                 535                 540             


<210>  129
<211>  196
<212>  PRT
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(196)
<223>  Cse2

<400>  129

Met Thr Ala Pro Asn Glu Asn Lys Glu His Gln Lys Ser Lys Lys Asp 
1               5                   10                  15      


Glu Glu Phe Leu Ala Asn Leu Ala Lys Met Ala Glu Ser Asp Arg Gly 
            20                  25                  30          


Gly Met Ala Ile Leu Lys Arg Asn Ala Gly Asn Thr Ile Ala Glu Ser 
        35                  40                  45              


Arg Gly Ala Met Lys Thr Phe Tyr Ser Leu Leu Pro Tyr Gly Ile Ser 
    50                  55                  60                  


Asp Ser Pro Tyr Glu Glu Ile Tyr Phe Leu Ile Ala Thr Leu Tyr Gly 
65                  70                  75                  80  


His Asn Lys Tyr Arg Phe Thr Gly Asp Phe Gly Gln Thr Met Lys Leu 
                85                  90                  95      


Val Arg Glu Ser Ser Asn Ser Glu Ser Ile Asp Gln Arg Val Ser Thr 
            100                 105                 110         


Leu Leu Asp Ser Glu Phe Asn Ile Val Asp Gly Ile Lys Pro Gly Gly 
        115                 120                 125             


Gly Glu Leu Ala Tyr Arg Leu Arg Gln Cys Val Lys Leu Ala Ser Gly 
    130                 135                 140                 


His Glu Ile Gly Val Asp Trp Tyr Arg Leu Leu Gln Asp Leu Lys Tyr 
145                 150                 155                 160 


Trp Gly Tyr Pro Glu Lys Arg Val Gln Lys Arg Trp Ala Arg Ser Tyr 
                165                 170                 175     


Phe Gly Tyr Gly Lys Pro Val Glu Ser Glu Thr Lys Glu Ser Lys Glu 
            180                 185                 190         


Glu Ala Lys Ala 
        195     


<210>  130
<211>  391
<212>  PRT
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(391)
<223>  Cas7

<400>  130

Met Lys Leu Ile Glu Ile His Met Ile Gln Asn His Ala Pro Cys Asn 
1               5                   10                  15      


Leu Asn Arg Asp Asp Thr Gly Ser Pro Lys Asp Cys Met Phe Gly Gly 
            20                  25                  30          


Ile Arg Arg Ser Arg Ile Ser Ser Gln Ser Ile Lys Arg Ser Ile Arg 
        35                  40                  45              


Met Ser Pro Ile Phe Lys Glu Glu Met Lys Gly Ile Glu Leu Ala Asn 
    50                  55                  60                  


Arg Thr Arg Arg Leu Pro Glu Leu Val Lys Ala Lys Leu Ile Ser Asp 
65                  70                  75                  80  


Gly Ile Asp Glu Lys Met Ala Ala Ile Ala Ala Glu Lys Ala Thr Gly 
                85                  90                  95      


Phe Gly Thr Lys Asp Gly Lys Glu Arg Glu Glu Asp Leu Asn Thr Ala 
            100                 105                 110         


Gln Thr Met Phe Ile Thr Gln Ser Asp Val Asp Ala Val Ala Ser Val 
        115                 120                 125             


Met Lys Asp Ala Ile Leu Lys Ala Gly Asn Pro Lys Ala Phe Lys Asp 
    130                 135                 140                 


Met Lys Ala Ala Asp Leu Gln Lys Ala Ala Glu Leu Lys Gly Trp Arg 
145                 150                 155                 160 


Pro Val Thr Pro Asp Leu Ala Leu Phe Gly Arg Met Ile Thr Ser Asp 
                165                 170                 175     


Ala Phe Met Asp Ile Glu Ala Ser Met Gln Val Ala His Ala Ile Ser 
            180                 185                 190         


Thr Asn Lys Met Asp His Glu Phe Asp Tyr Phe Thr Ala Val Asp Asp 
        195                 200                 205             


Leu Gln Lys Ser Ser Asp Gly Pro Gly Ala Asp Met Ile Gly Asp Val 
    210                 215                 220                 


Gln Phe Asn Ser Ala Cys Tyr Tyr Lys Tyr Phe Ser Leu Asp Tyr Asp 
225                 230                 235                 240 


Ala Leu Ile Gln Asn Leu Ala Gly Leu Lys Pro Gly Asp Asn Ala Thr 
                245                 250                 255     


Glu Ala Asp Lys Lys Ala Tyr Ala Glu Ser Leu Glu Asn Ala Lys Lys 
            260                 265                 270         


Val Ala Ala Ile Thr Ile Thr Ala Phe Leu Lys Ala Ala Ile Tyr Thr 
        275                 280                 285             


Thr Pro Ser Gly Lys Gln Asn Ser Phe Ala Ala His Gln Leu Pro Ser 
    290                 295                 300                 


Ala Val Leu Val Glu Ile Arg Pro Thr Lys Thr Pro Val Ser Tyr Ala 
305                 310                 315                 320 


Asn Ala Phe Val Asp Pro Ala Arg Pro Arg Asn Gly Val Asp Met Val 
                325                 330                 335     


Glu Asp Thr Leu Asn Lys Phe Val Lys His Val Glu Leu Gln Thr Glu 
            340                 345                 350         


Lys Phe Asn Leu Arg Ser Thr Arg Arg Leu Trp Phe Val Ala Gly Asp 
        355                 360                 365             


Lys Ala Leu Ala Gly Thr Glu Thr Cys Gln Thr Ile Asn Asp Leu Ile 
    370                 375                 380                 


Ser Gly Ile Asn Ser Ala Leu 
385                 390     


<210>  131
<211>  227
<212>  PRT
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(227)
<223>  Cas5

<400>  131

Met Asp Asn Pro Leu Leu Leu Leu Leu Arg Leu Glu Gly Pro Met Gln 
1               5                   10                  15      


Ser Trp Gly Leu Lys Ala Arg Trp Asp Ile Arg Asp Thr Gly Asp Glu 
            20                  25                  30          


Pro Thr Lys Ser Gly Ile Ile Gly Leu Leu Gly Cys Ala Leu Gly Tyr 
        35                  40                  45              


Ala Arg Lys Asp Pro Arg Leu Thr Asp Glu Leu Asp Ser Gln Leu Arg 
    50                  55                  60                  


Ile Gly Ile Arg Val Glu Cys Pro Gly Glu Ile Ala Arg Asp Tyr His 
65                  70                  75                  80  


Thr Val Ser Gly Glu Leu Arg Thr Ala Glu Gly Lys Leu Arg Glu Thr 
                85                  90                  95      


Thr Ile Val Ser Phe Arg Asp Tyr Leu Gln Asp Ala Ala Phe Leu Val 
            100                 105                 110         


Val Leu Glu Gly Pro Gly Glu Leu Leu Thr Arg Ile Ser Asn Ala Leu 
        115                 120                 125             


Lys Asp Pro Val Trp Pro Ile Tyr Leu Gly Arg Lys Ser Cys Pro Pro 
    130                 135                 140                 


Thr Arg Pro Val Phe Glu Thr Leu Thr Thr Asp Tyr Ala Ser Ile Asp 
145                 150                 155                 160 


Asp Ala Leu Ser Arg His Pro Trp Ser Ser Gly Thr Met Glu Ala Arg 
                165                 170                 175     


Lys Ala His Pro Lys Glu Leu Lys Cys Ile Val Glu Asp Leu Ser Gly 
            180                 185                 190         


Pro Tyr Gln Arg Thr Asp Arg Met Thr Lys Ser Pro Ala Arg Met Tyr 
        195                 200                 205             


Gly Ile Arg His Val Arg Met Ser Thr Val Lys Leu Gln Ala Glu Gly 
    210                 215                 220                 


Glu Gly Leu 
225         


<210>  132
<211>  250
<212>  PRT
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(250)
<223>  Cas6

<400>  132

Met Tyr Leu Ser Arg Leu Ile Leu Asn Pro Arg Thr Arg Ala Val Arg 
1               5                   10                  15      


Arg Asp Leu Ala Asp Cys His Glu Leu His Arg Thr Ile Leu Gly Gly 
            20                  25                  30          


Phe Pro Asp Leu Asn Gly Lys Gly Gly Glu Ala Arg Glu Thr Phe Gly 
        35                  40                  45              


Val Leu His Arg Ile Asp Ile His Pro Arg Ser Gly Ala Ile Val Leu 
    50                  55                  60                  


Leu Val Gln Ser Gln Glu Lys Pro Asp Trp Ser Lys Leu Pro Glu Gly 
65                  70                  75                  80  


Tyr Leu Leu Glu Asn Thr Gly Thr Glu Asn Pro Ala Cys Lys Ala Ile 
                85                  90                  95      


Asp Glu Gln Tyr Gly Lys Ile Lys Ala Gly Asp Val Tyr Ala Phe Arg 
            100                 105                 110         


Leu Arg Ala Asn Pro Thr Lys Lys Ile Gly Thr Ser Arg Ile Glu Asp 
        115                 120                 125             


Ile Lys Ala Gly Lys Pro Lys Asn Asn Gly Arg Arg Val Pro Ile Arg 
    130                 135                 140                 


Asn Glu Ser Asp Gln Ile Leu Trp Leu Lys Arg Lys Gly Ala Ala Gly 
145                 150                 155                 160 


Gly Phe Glu Leu Met Ser Thr Lys Arg Phe Ser Glu Leu Ser Asp Val 
                165                 170                 175     


Leu Ile Ser Glu Glu Gly His Gln Lys Ile Tyr Thr Phe Asp Thr Gly 
            180                 185                 190         


Ile Lys Ala Lys Val Gln Lys Asn Ala Arg Glu Asn Arg Leu Thr Phe 
        195                 200                 205             


Gly Ser Val Leu Phe Glu Gly Thr Leu Lys Val Thr Asn Ala Glu Lys 
    210                 215                 220                 


Phe Leu Glu Thr Leu Lys Ser Gly Ile Gly Ser Gly Lys Ala Tyr Gly 
225                 230                 235                 240 


Phe Gly Leu Leu Ser Leu Ala Pro Ala Arg 
                245                 250 


<210>  133
<211>  90
<212>  DNA
<213>  Methanocella arvoryzae MRE50


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  133
aaagtcccca caggcgtggg ggtgaaccgt gatcagtaac ccggtcacca ttaaacagat       60

taaagtcccc acaggcgtgg gggtgaaccg                                        90


<210>  134
<211>  1701
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(1701)
<223>  Cas8

<400>  134
atgtgtgacc aacagtatgt tagtacactg aatgtattaa aagatccgtg gattccagtt       60

gtatttttgg atggaaagat aaaagatgtt ggaatcattg aatgctttag aaatgcagaa      120

aagattaaaa caatatcgaa ttctaagcca tatgaaaaga ttgcgatact acggtttttg      180

acagcgttca ttacggatgt atatcaactg gatagacgta ttgaacggca aaagttatat      240

gatgcgggat catttgaaat tgaacgtatt gagaattatg ttaaagaatg tgaagagaag      300

aatggagctt catttgtttt gggtgattct caaagatctt ttttttgctt taactataat      360

ccgcaagttg atacagaggg agtgaaatta tctgcagcgt atttgcattt ggaactgcct      420

catggcaata atcctattca catagttgcc cagagagagg aagattttga aggtgatacg      480

ctgcctcaat ttttgagggc tgcattagcg tttaatttat tcccgactgg aaacatgtta      540

aagggagcga atagtaaaac gggtgataac tgctatatag acggtgtggg gaaagatggc      600

aaacctaaat atacagctgc gtatggctcg atgggaataa atgcaggaag ttcaatggca      660

gcggctgaac cggttttctt ttggccagaa tgtgacaatt tgtttcatac acttgttatg      720

tgtatgcgca gtcaaggaga actacagaat aatttaaaat taaatgatcc accagctttt      780

tggaatgccg atgcagaacc taatcctaaa gcaggaaaac gtggtgatat agtaacttca      840

gtctcttttg tgtcaggtct tgcttttcag gcaagaagaa ttgtaccggt cattgaaaac      900

ggaaaagttt atgaatgcta tataagtaat ggttatacca attcgaatga aaacgtgtgg      960

catgatcctt ttgctgttag attgagaaat cataagtcgg gagaaatttt tcagatgccg     1020

gctaaagggg atcgagaaat gtggagaaat attggaaatt tgactgcatc tagagaagaa     1080

agctggcatt taatgccgga tgtccttaga ccaattaaaa aaagtgcaga tgctacagat     1140

tattatgaga atatttcttc tcttgcaatg atacctatga cccagaatgc aggatacagt     1200

gctatgttct atgatgatac agtacaaatt ccgaaagaat atttggaaga ctcatatttg     1260

ggtgaatatt taactacaag aatggaaata gtagaagaaa tttctaagat gtgggacaag     1320

cttaaaatat cggcgcttct ggataataag gataaatttt caggacatta tagagatgat     1380

gcactgcaag agtattgggt caagattcat caatttttat ttgatggcga tgatagcttc     1440

ttaaatcatg tgataagaat gtatcatgaa gattcttctt cttttgaaaa aacggcagat     1500

aaagcattat ttgaatattt aacgaagagt gttaaagaaa tatgcgaaaa agaagagaag     1560

aacacgaatt catggaatat gttggtgaaa ataatcaggc aaatacatgg taagaatggc     1620

tgtcttcata ttttttacgg aacgttaaag aaatattgga agaaggaggg aaaggataag     1680

aatgatacag gaagcatatg a                                               1701


<210>  135
<211>  498
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(498)
<223>  Cse2

<400>  135
atgatacagg aagcatatga aaaacttgca catgaggaaa aaaggttgtt tgctcattgt       60

gcaggtaaat taataaaaga cgctccaaaa gctattatac cgttttataa ggtggtgcca      120

agtgaaattg aaagtaaaaa cgggaaaaag tatacagttg atgaagatgc tttttttgct      180

gctttgtgtg taagatgcct attcgaaaaa attgagggcg ttacattaga acctgacata      240

ttaattagtg aaggaagaaa aaatcctaaa atatctttgg aaggttatga tagaagaatt      300

tcagcattaa tgtcaaatac tgaagctgaa ttttttattc caaaacttgc aaagttaatg      360

aattatacgc taaaaattac ttctaataaa ataccggatt gtgatcagtt atattgggat      420

attcataata ttggaagcaa tgaaaaagat gttcagcgac gttgggcacg tacaatatat      480

gtaaataatg aagagtga                                                    498


<210>  136
<211>  1188
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(1188)
<223>  Cas7

<400>  136
atgagtaatt caaagtatca gttcttaaat ggaaagaaac ttgcagagtt tcatatgttg       60

aagctatatc cgtcatcagc attaaaccgc gatgatgcag gtgagcagaa aacgggaatg      120

tacaatggca cgcttaggaa tagaatttca agtcagtgta ttaaacgttc atggaggctt      180

tctgaaactt tcgaagatgt ttttgatgaa attggaatac gtactaagag aatgccagaa      240

tatgttggaa aaaaattggt tgagaatgga gtgccggaag aggatgtaat cagttttaag      300

aaaatccttt ctggtgaaaa ggttgatgaa aaatcatcta agaaaagtaa agctgatcag      360

gctatagacg aaggtaagcc agtaaagact gctgcattgt cattttattc agtggaggaa      420

cttgataaaa ttgctgagat atgtaaaaga atttatgatg atttggaaga gcctaaatcc      480

aaaaatctga agacaataaa aattgacaat attcagaagg aaatgcgtaa gtgcgttcat      540

ccgatgaata ttgatgttgc agcatttggg cgtatggtaa ctgacaacat gcttcgtccg      600

gtagaaggcg caatgcaggt ggcacaggca ttatcaacta atgctgcggt caaggaaaat      660

gactattttg tggcttgcga tgatctggta aaaggagaaa ccattgaaga tgtcggtggt      720

gaaatgcttg gagatattga ctataattct gcatgctatt atattcatgc aaatgcagat      780

ttagagcagt ttgcagaaaa tttgaaggat tgtgaaaaca tggaagaaat agtgaaagca      840

ttgccttcaa atatggtgga agtaatggca tatacagatc caacagcgag acagagtaca      900

atggaggcgc atgttcttcc agaggttatt tatgtggaac taaagagtaa aaagcgtcct      960

ttgaacagaa tgaaggcatt tgcggaaccg tgtaatagaa atattgctga aaagagtgct     1020

aaaaaacttg ctgattatat aaattgcaca aacgaaaaag ctgatttagg aataacaaat     1080

gcactgtggt attgtgagga tgaaagtgtt aaagcgcctg aaaatgttac tgtagtgaac     1140

agtataaaag aacttgagca aaagcttaat gagtggatga atgaatga                  1188


<210>  137
<211>  483
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Cas5

<400>  137
atgaaaataa aaattgtttt agaaggtgca tttcaagcct ggggagtacc atctgaatat       60

acttggagag gaacatcgta ttatccgaca gctagaggaa ttgtaggttt gattggatgt      120

tgtatgggta taccaagggg agatgatagg cttgagcagc tattatcggt gttaaaaata      180

acatatgata taaacgaaga tgataatggg aacagaaaat caggatcaat acttacagat      240

tttcaggttg tgagaaagga agatggcggc aagttaaatg cagcgaatgg aggaactggc      300

gattcatatg gaatcatatt gcataaatcc tacataaatg atgcatcatt tacggttcat      360

atagagggtc ctgatgatct gatgaaagat gtatatgatg caatgcttga tccagtttgg      420

gttccatatc taggaagaaa aaattgtccg cctacagaac cacttattcc tgaaattgaa      480

tag                                                                    483


<210>  138
<211>  618
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(618)
<223>  Cas6

<400>  138
atgtatttaa caaaattaga attaaatata caaaacaaag ctgttcttca taatatgtca       60

aattgtgaat ggatgcataa gctgattctt gaaaaaggat ttggacatat tcaagccgaa      120

aatgcaagac agacgttaaa gatattatat gctgtagatg gcataaaagt ttatgttcaa      180

agtgctgtag aacccaaatt tgaaaattgt tcatattgga taagtactcc ggctaccatt      240

tgtattgatg cgatgaaaaa aatttgtggg acaggtatgg ctgtacattt taaatgtacg      300

tgtaatccaa cgaaaaagtt gatcgatggc ggaaagcgta tttttctatc atctgagaga      360

gagagagatg agtggattaa gcgtgtgatg gagcgttccg gagcagaagt tttggttgag      420

agtcagactt ctgactttac ggtatgggga atgaagaaag ataaaaaaac agataaatct      480

cacaaaattt atgctaaagc ggtcacatat tcaggtgcac taaaaataac agatgaagaa      540

aaattttggg aagcattttg taatggcata ggtcgagaaa aagcttatgg ttgtggaatg      600

ttaatgatac aggtttga                                                    618


<210>  139
<211>  1701
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(1701)
<223>  Cas8

<400>  139
atgtgcgatc agcagtacgt gtctacactg aatgtgctga aggacccttg gattcccgtg       60

gtgtttctgg acggcaagat caaggatgtg ggcatcatcg agtgtttcag aaacgccgag      120

aagatcaaga ccatctctaa cagcaagcca tatgagaaga tcgccatcct gagatttctg      180

accgccttca tcacagacgt gtaccagctg gataggcgca tcgagaggca gaagctgtat      240

gacgccggct ctttcgagat cgagcgcatc gagaattacg tgaaggagtg cgaggagaag      300

aacggcgcca gctttgtgct gggcgatagc cagcggtcct tcttttgttt caactacaat      360

ccccaggtgg acaccgaggg agtgaagctg agcgccgcct atctgcacct ggagctgcct      420

cacggcaaca atccaatcca catcgtggcc cagagggagg aggactttga gggcgataca      480

ctgccacagt tcctgagggc cgccctggcc tttaatctgt tccctaccgg caacatgctg      540

aagggcgcca attctaagac aggcgacaac tgctacatcg atggcgtggg caaggacggc      600

aagcctaagt acaccgccgc ctatggcagc atgggcatca atgcaggctc tagcatggca      660

gcagcagagc ccgtgttctt ttggcctgag tgcgataacc tgtttcacac actggtcatg      720

tgcatgaggt cccagggcga gctgcagaac aatctgaagc tgaacgatcc tccagccttc      780

tggaatgcag acgcagagcc aaaccctaag gcaggcaaga ggggcgacat cgtgaccagc      840

gtgagcttcg tgagcggcct ggcattccag gcaaggagaa tcgtgccagt gatcgagaat      900

ggcaaggtgt acgagtgtta tatctctaac ggctacacaa acagcaatga gaacgtgtgg      960

cacgatccat ttgccgtgag gctgcgcaac cacaagtccg gcgagatctt ccagatgcca     1020

gcaaagggcg acagggagat gtggcgcaat atcggcaacc tgaccgcctc cagggaggag     1080

tcttggcacc tgatgccaga tgtgctgcgc cccatcaaga agagcgccga cgccacagat     1140

tactatgaga atatctcctc tctggccatg atcccaatga cccagaacgc cggctacagc     1200

gccatgttct atgacgatac agtgcagatc cccaaggagt acctggagga ttcctacctg     1260

ggcgagtatc tgaccacaag gatggagatc gtggaggaga tctctaagat gtgggacaag     1320

ctgaagatca gcgccctgct ggacaataag gataagtttt ccggccacta cagggacgat     1380

gccctgcagg agtattgggt gaagatccac cagtttctgt tcgacggcga cgattctttc     1440

ctgaaccacg tgatcagaat gtaccacgag gatagctcct cttttgagaa gaccgccgac     1500

aaggccctgt tcgagtatct gacaaagagc gtgaaggaga tctgcgagaa ggaggagaag     1560

aataccaact cctggaatat gctggtgaag atcatccgcc agatccacgg caagaacggc     1620

tgtctgcaca tcttctacgg caccctgaag aagtattgga agaaggaggg caaggacaag     1680

aacgatacag gcagcatcta a                                               1701


<210>  140
<211>  498
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(498)
<223>  Cse2

<400>  140
atgatccagg aggcctacga gaagctggcc cacgaggaga agcggctgtt tgcccactgt       60

gccggcaagc tgatcaagga cgccccaaag gccatcatcc ccttctacaa ggtggtgccc      120

tccgagatcg agtctaaaaa cggcaagaag tataccgtgg acgaggatgc cttctttgcc      180

gccctgtgcg tgaggtgtct gtttgagaag atcgagggcg tgacactgga gcccgatatc      240

ctgatcagcg agggccgcaa gaatcctaag atctccctgg agggctatga ccggagaatc      300

agcgccctga tgtccaacac cgaggccgag ttctttatcc ctaagctggc caagctgatg      360

aattacaccc tgaagatcac atccaacaag atcccagact gcgatcagct gtattgggat      420

atccacaata tcggctctaa cgagaaggac gtgcagaggc gctgggcaag gaccatctac      480

gtgaacaatg aggagtaa                                                    498


<210>  141
<211>  1188
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(1188)
<223>  Cas7

<400>  141
atgagcaatt ccaagtacca gtttctgaac ggcaagaagc tggccgagtt ccacatgctg       60

aagctgtatc ctagctccgc cctgaacaga gacgatgccg gcgagcagaa gaccggcatg      120

tataatggca cactgaggaa cagaatctct agccagtgca tcaagcggtc ttggagactg      180

agcgagacct ttgaggacgt gttcgatgag atcggcatca ggacaaagcg catgccagag      240

tacgtgggca agaagctggt ggagaatggc gtgcccgagg aggatgtgat ctcttttaag      300

aagatcctga gcggcgagaa ggtggacgag aagtcctcta agaagtccaa ggccgaccag      360

gccatcgatg agggcaagcc tgtgaagacc gccgccctga gcttctactc cgtggaggag      420

ctggataaga tcgccgagat ctgcaagagg atctatgacg atctggagga gccaaagtcc      480

aagaatctga agacaatcaa gatcgacaac atccagaagg agatgcgcaa gtgcgtgcac      540

cccatgaata tcgatgtggc cgcctttggc aggatggtga ccgacaacat gctgaggcct      600

gtggagggag caatgcaggt ggcccaggcc ctgtctacaa atgccgccgt gaaggagaac      660

gattatttcg tggcctgcga cgatctggtg aagggagaga ccatcgagga cgtgggagga      720

gagatgctgg gcgacatcga ttacaatagc gcctgctact atatccacgc caacgccgat      780

ctggagcagt ttgccgagaa tctgaaggac tgtgagaaca tggaggagat cgtgaaggcc      840

ctgccatcta atatggtgga agtgatggcc tacaccgacc ccacagccag gcagagcacc      900

atggaggccc acgtgctgcc cgaagtgatc tacgtggagc tgaagagcaa gaagcggcca      960

ctgaacagaa tgaaggcctt cgccgagccc tgtaaccgca atatcgccga gaagtccgcc     1020

aagaagctgg ccgattacat caattgcacc aacgagaagg ccgacctggg catcacaaat     1080

gccctgtggt attgtgagga tgagagcgtg aaggccccag agaatgtgac cgtggtgaac     1140

tccatcaagg agctggagca gaagctgaat gagtggatga acgagtaa                  1188


<210>  142
<211>  483
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Cas5

<400>  142
atgaagatca agatcgtgct ggagggagca ttccaggcct ggggagtgcc ttccgagtat       60

acctggcggg gcacatctta ctatccaacc gccagaggca tcgtgggcct gatcggctgc      120

tgtatgggca tccctagggg cgacgatcgc ctggagcagc tgctgtccgt gctgaagatc      180

acctacgaca tcaacgagga cgataacggc aatcggaagt ctggcagcat cctgacagat      240

tttcaggtgg tgagaaagga ggacggaggc aagctgaatg cagcaaacgg aggaaccggc      300

gatagctacg gcatcatcct gcacaagtct tatatcaatg acgccagctt cacagtgcac      360

atcgagggcc ctgacgatct gatgaaggac gtgtacgatg ccatgctgga ccccgtgtgg      420

gtgccttatc tgggcagaaa gaattgccct ccaaccgagc cactgatccc cgagattgaa      480

taa                                                                    483


<210>  143
<211>  618
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(618)
<223>  Cas6

<400>  143
atgtacctga ccaagctgga gctgaatatc cagaacaagg ccgtgctgca caatatgtct       60

aactgcgagt ggatgcacaa gctgatcctg gagaagggct ttggccacat ccaggccgag      120

aatgcccggc agacactgaa gatcctgtac gccgtggatg gcatcaaggt gtatgtgcag      180

tccgccgtgg agcccaagtt cgagaactgt tcttactgga tcagcacccc tgccacaatc      240

tgcatcgacg ccatgaagaa gatctgtggc accggcatgg ccgtgcactt taagtgcacc      300

tgtaacccca caaagaagct gatcgatggc ggcaagagaa tcttcctgag ctccgagcgg      360

gagagagacg agtggatcaa gagagtgatg gagagaagcg gcgccgaggt gctggtggag      420

tctcagacca gcgatttcac agtgtggggc atgaagaagg acaagaagac cgataagtcc      480

cacaagatct acgccaaggc cgtgacctat tctggcgccc tgaagatcac agacgaggag      540

aagttttggg aggccttctg caatggcatc ggccgggaga aggcctacgg ctgtggcatg      600

ctgatgatcc aagtctaa                                                    618


<210>  144
<211>  566
<212>  PRT
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(566)
<223>  Cas8

<400>  144

Met Cys Asp Gln Gln Tyr Val Ser Thr Leu Asn Val Leu Lys Asp Pro 
1               5                   10                  15      


Trp Ile Pro Val Val Phe Leu Asp Gly Lys Ile Lys Asp Val Gly Ile 
            20                  25                  30          


Ile Glu Cys Phe Arg Asn Ala Glu Lys Ile Lys Thr Ile Ser Asn Ser 
        35                  40                  45              


Lys Pro Tyr Glu Lys Ile Ala Ile Leu Arg Phe Leu Thr Ala Phe Ile 
    50                  55                  60                  


Thr Asp Val Tyr Gln Leu Asp Arg Arg Ile Glu Arg Gln Lys Leu Tyr 
65                  70                  75                  80  


Asp Ala Gly Ser Phe Glu Ile Glu Arg Ile Glu Asn Tyr Val Lys Glu 
                85                  90                  95      


Cys Glu Glu Lys Asn Gly Ala Ser Phe Val Leu Gly Asp Ser Gln Arg 
            100                 105                 110         


Ser Phe Phe Cys Phe Asn Tyr Asn Pro Gln Val Asp Thr Glu Gly Val 
        115                 120                 125             


Lys Leu Ser Ala Ala Tyr Leu His Leu Glu Leu Pro His Gly Asn Asn 
    130                 135                 140                 


Pro Ile His Ile Val Ala Gln Arg Glu Glu Asp Phe Glu Gly Asp Thr 
145                 150                 155                 160 


Leu Pro Gln Phe Leu Arg Ala Ala Leu Ala Phe Asn Leu Phe Pro Thr 
                165                 170                 175     


Gly Asn Met Leu Lys Gly Ala Asn Ser Lys Thr Gly Asp Asn Cys Tyr 
            180                 185                 190         


Ile Asp Gly Val Gly Lys Asp Gly Lys Pro Lys Tyr Thr Ala Ala Tyr 
        195                 200                 205             


Gly Ser Met Gly Ile Asn Ala Gly Ser Ser Met Ala Ala Ala Glu Pro 
    210                 215                 220                 


Val Phe Phe Trp Pro Glu Cys Asp Asn Leu Phe His Thr Leu Val Met 
225                 230                 235                 240 


Cys Met Arg Ser Gln Gly Glu Leu Gln Asn Asn Leu Lys Leu Asn Asp 
                245                 250                 255     


Pro Pro Ala Phe Trp Asn Ala Asp Ala Glu Pro Asn Pro Lys Ala Gly 
            260                 265                 270         


Lys Arg Gly Asp Ile Val Thr Ser Val Ser Phe Val Ser Gly Leu Ala 
        275                 280                 285             


Phe Gln Ala Arg Arg Ile Val Pro Val Ile Glu Asn Gly Lys Val Tyr 
    290                 295                 300                 


Glu Cys Tyr Ile Ser Asn Gly Tyr Thr Asn Ser Asn Glu Asn Val Trp 
305                 310                 315                 320 


His Asp Pro Phe Ala Val Arg Leu Arg Asn His Lys Ser Gly Glu Ile 
                325                 330                 335     


Phe Gln Met Pro Ala Lys Gly Asp Arg Glu Met Trp Arg Asn Ile Gly 
            340                 345                 350         


Asn Leu Thr Ala Ser Arg Glu Glu Ser Trp His Leu Met Pro Asp Val 
        355                 360                 365             


Leu Arg Pro Ile Lys Lys Ser Ala Asp Ala Thr Asp Tyr Tyr Glu Asn 
    370                 375                 380                 


Ile Ser Ser Leu Ala Met Ile Pro Met Thr Gln Asn Ala Gly Tyr Ser 
385                 390                 395                 400 


Ala Met Phe Tyr Asp Asp Thr Val Gln Ile Pro Lys Glu Tyr Leu Glu 
                405                 410                 415     


Asp Ser Tyr Leu Gly Glu Tyr Leu Thr Thr Arg Met Glu Ile Val Glu 
            420                 425                 430         


Glu Ile Ser Lys Met Trp Asp Lys Leu Lys Ile Ser Ala Leu Leu Asp 
        435                 440                 445             


Asn Lys Asp Lys Phe Ser Gly His Tyr Arg Asp Asp Ala Leu Gln Glu 
    450                 455                 460                 


Tyr Trp Val Lys Ile His Gln Phe Leu Phe Asp Gly Asp Asp Ser Phe 
465                 470                 475                 480 


Leu Asn His Val Ile Arg Met Tyr His Glu Asp Ser Ser Ser Phe Glu 
                485                 490                 495     


Lys Thr Ala Asp Lys Ala Leu Phe Glu Tyr Leu Thr Lys Ser Val Lys 
            500                 505                 510         


Glu Ile Cys Glu Lys Glu Glu Lys Asn Thr Asn Ser Trp Asn Met Leu 
        515                 520                 525             


Val Lys Ile Ile Arg Gln Ile His Gly Lys Asn Gly Cys Leu His Ile 
    530                 535                 540                 


Phe Tyr Gly Thr Leu Lys Lys Tyr Trp Lys Lys Glu Gly Lys Asp Lys 
545                 550                 555                 560 


Asn Asp Thr Gly Ser Ile 
                565     


<210>  145
<211>  165
<212>  PRT
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(165)
<223>  Cse2

<400>  145

Met Ile Gln Glu Ala Tyr Glu Lys Leu Ala His Glu Glu Lys Arg Leu 
1               5                   10                  15      


Phe Ala His Cys Ala Gly Lys Leu Ile Lys Asp Ala Pro Lys Ala Ile 
            20                  25                  30          


Ile Pro Phe Tyr Lys Val Val Pro Ser Glu Ile Glu Ser Lys Asn Gly 
        35                  40                  45              


Lys Lys Tyr Thr Val Asp Glu Asp Ala Phe Phe Ala Ala Leu Cys Val 
    50                  55                  60                  


Arg Cys Leu Phe Glu Lys Ile Glu Gly Val Thr Leu Glu Pro Asp Ile 
65                  70                  75                  80  


Leu Ile Ser Glu Gly Arg Lys Asn Pro Lys Ile Ser Leu Glu Gly Tyr 
                85                  90                  95      


Asp Arg Arg Ile Ser Ala Leu Met Ser Asn Thr Glu Ala Glu Phe Phe 
            100                 105                 110         


Ile Pro Lys Leu Ala Lys Leu Met Asn Tyr Thr Leu Lys Ile Thr Ser 
        115                 120                 125             


Asn Lys Ile Pro Asp Cys Asp Gln Leu Tyr Trp Asp Ile His Asn Ile 
    130                 135                 140                 


Gly Ser Asn Glu Lys Asp Val Gln Arg Arg Trp Ala Arg Thr Ile Tyr 
145                 150                 155                 160 


Val Asn Asn Glu Glu 
                165 


<210>  146
<211>  395
<212>  PRT
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(395)
<223>  Cas7

<400>  146

Met Ser Asn Ser Lys Tyr Gln Phe Leu Asn Gly Lys Lys Leu Ala Glu 
1               5                   10                  15      


Phe His Met Leu Lys Leu Tyr Pro Ser Ser Ala Leu Asn Arg Asp Asp 
            20                  25                  30          


Ala Gly Glu Gln Lys Thr Gly Met Tyr Asn Gly Thr Leu Arg Asn Arg 
        35                  40                  45              


Ile Ser Ser Gln Cys Ile Lys Arg Ser Trp Arg Leu Ser Glu Thr Phe 
    50                  55                  60                  


Glu Asp Val Phe Asp Glu Ile Gly Ile Arg Thr Lys Arg Met Pro Glu 
65                  70                  75                  80  


Tyr Val Gly Lys Lys Leu Val Glu Asn Gly Val Pro Glu Glu Asp Val 
                85                  90                  95      


Ile Ser Phe Lys Lys Ile Leu Ser Gly Glu Lys Val Asp Glu Lys Ser 
            100                 105                 110         


Ser Lys Lys Ser Lys Ala Asp Gln Ala Ile Asp Glu Gly Lys Pro Val 
        115                 120                 125             


Lys Thr Ala Ala Leu Ser Phe Tyr Ser Val Glu Glu Leu Asp Lys Ile 
    130                 135                 140                 


Ala Glu Ile Cys Lys Arg Ile Tyr Asp Asp Leu Glu Glu Pro Lys Ser 
145                 150                 155                 160 


Lys Asn Leu Lys Thr Ile Lys Ile Asp Asn Ile Gln Lys Glu Met Arg 
                165                 170                 175     


Lys Cys Val His Pro Met Asn Ile Asp Val Ala Ala Phe Gly Arg Met 
            180                 185                 190         


Val Thr Asp Asn Met Leu Arg Pro Val Glu Gly Ala Met Gln Val Ala 
        195                 200                 205             


Gln Ala Leu Ser Thr Asn Ala Ala Val Lys Glu Asn Asp Tyr Phe Val 
    210                 215                 220                 


Ala Cys Asp Asp Leu Val Lys Gly Glu Thr Ile Glu Asp Val Gly Gly 
225                 230                 235                 240 


Glu Met Leu Gly Asp Ile Asp Tyr Asn Ser Ala Cys Tyr Tyr Ile His 
                245                 250                 255     


Ala Asn Ala Asp Leu Glu Gln Phe Ala Glu Asn Leu Lys Asp Cys Glu 
            260                 265                 270         


Asn Met Glu Glu Ile Val Lys Ala Leu Pro Ser Asn Met Val Glu Val 
        275                 280                 285             


Met Ala Tyr Thr Asp Pro Thr Ala Arg Gln Ser Thr Met Glu Ala His 
    290                 295                 300                 


Val Leu Pro Glu Val Ile Tyr Val Glu Leu Lys Ser Lys Lys Arg Pro 
305                 310                 315                 320 


Leu Asn Arg Met Lys Ala Phe Ala Glu Pro Cys Asn Arg Asn Ile Ala 
                325                 330                 335     


Glu Lys Ser Ala Lys Lys Leu Ala Asp Tyr Ile Asn Cys Thr Asn Glu 
            340                 345                 350         


Lys Ala Asp Leu Gly Ile Thr Asn Ala Leu Trp Tyr Cys Glu Asp Glu 
        355                 360                 365             


Ser Val Lys Ala Pro Glu Asn Val Thr Val Val Asn Ser Ile Lys Glu 
    370                 375                 380                 


Leu Glu Gln Lys Leu Asn Glu Trp Met Asn Glu 
385                 390                 395 


<210>  147
<211>  160
<212>  PRT
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(160)
<223>  Cas5

<400>  147

Met Lys Ile Lys Ile Val Leu Glu Gly Ala Phe Gln Ala Trp Gly Val 
1               5                   10                  15      


Pro Ser Glu Tyr Thr Trp Arg Gly Thr Ser Tyr Tyr Pro Thr Ala Arg 
            20                  25                  30          


Gly Ile Val Gly Leu Ile Gly Cys Cys Met Gly Ile Pro Arg Gly Asp 
        35                  40                  45              


Asp Arg Leu Glu Gln Leu Leu Ser Val Leu Lys Ile Thr Tyr Asp Ile 
    50                  55                  60                  


Asn Glu Asp Asp Asn Gly Asn Arg Lys Ser Gly Ser Ile Leu Thr Asp 
65                  70                  75                  80  


Phe Gln Val Val Arg Lys Glu Asp Gly Gly Lys Leu Asn Ala Ala Asn 
                85                  90                  95      


Gly Gly Thr Gly Asp Ser Tyr Gly Ile Ile Leu His Lys Ser Tyr Ile 
            100                 105                 110         


Asn Asp Ala Ser Phe Thr Val His Ile Glu Gly Pro Asp Asp Leu Met 
        115                 120                 125             


Lys Asp Val Tyr Asp Ala Met Leu Asp Pro Val Trp Val Pro Tyr Leu 
    130                 135                 140                 


Gly Arg Lys Asn Cys Pro Pro Thr Glu Pro Leu Ile Pro Glu Ile Glu 
145                 150                 155                 160 


<210>  148
<211>  205
<212>  PRT
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(205)
<223>  Cas6

<400>  148

Met Tyr Leu Thr Lys Leu Glu Leu Asn Ile Gln Asn Lys Ala Val Leu 
1               5                   10                  15      


His Asn Met Ser Asn Cys Glu Trp Met His Lys Leu Ile Leu Glu Lys 
            20                  25                  30          


Gly Phe Gly His Ile Gln Ala Glu Asn Ala Arg Gln Thr Leu Lys Ile 
        35                  40                  45              


Leu Tyr Ala Val Asp Gly Ile Lys Val Tyr Val Gln Ser Ala Val Glu 
    50                  55                  60                  


Pro Lys Phe Glu Asn Cys Ser Tyr Trp Ile Ser Thr Pro Ala Thr Ile 
65                  70                  75                  80  


Cys Ile Asp Ala Met Lys Lys Ile Cys Gly Thr Gly Met Ala Val His 
                85                  90                  95      


Phe Lys Cys Thr Cys Asn Pro Thr Lys Lys Leu Ile Asp Gly Gly Lys 
            100                 105                 110         


Arg Ile Phe Leu Ser Ser Glu Arg Glu Arg Asp Glu Trp Ile Lys Arg 
        115                 120                 125             


Val Met Glu Arg Ser Gly Ala Glu Val Leu Val Glu Ser Gln Thr Ser 
    130                 135                 140                 


Asp Phe Thr Val Trp Gly Met Lys Lys Asp Lys Lys Thr Asp Lys Ser 
145                 150                 155                 160 


His Lys Ile Tyr Ala Lys Ala Val Thr Tyr Ser Gly Ala Leu Lys Ile 
                165                 170                 175     


Thr Asp Glu Glu Lys Phe Trp Glu Ala Phe Cys Asn Gly Ile Gly Arg 
            180                 185                 190         


Glu Lys Ala Tyr Gly Cys Gly Met Leu Met Ile Gln Val 
        195                 200                 205 


<210>  149
<211>  90
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  149
gtattcccca cgcacgtggg ggtaaatccg ctgagtttaa ttacgcagcg gaagccggag       60

cggtattccc cacgcacgtg ggggtaaatc                                        90


<210>  150
<211>  1524
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(1524)
<223>  Cas8

<400>  150
atggagaacc gcttcaattt gattgatgaa ccctggattg cggtcgtgga tgtggggttg       60

gtcagtttaa ccgatatttt cagccagccg gaattacgcg ctttaggtgg gaatccggta      120

gaaaaaatcg cgctcactaa attgctactc gccatcgccc aggcagcagc gacgccgaca      180

gatgatagcg actggcagca gatgggctgg cagggaatgg cccattgctg cctgcagtac      240

cttgctaaat ggcatgaccg tttttatctg tatggcgaaa agccgttctt acagatgccc      300

gctattcagg ccgcggaatg taagtcattg ggagtattat caccggaggt gagtaccggc      360

aataccaccg ttttgaccga aagtcagcaa cagcagcaat taactgatgc agacaaagcg      420

ctagctattg ttatgcaaat gggctttggg ctcggaggca agaaaaccga taactctgtg      480

gtattaacgc cgggctatcg gggtaaacaa aacgacaagg gaaagccggg cagtggaaag      540

gccggggttt ctgtcgggca tatgggattg ttacattcgt tctggcaggg gaattcaatc      600

gtacagagca tttggctcaa tttgtttacc gctgaggata ttacgcagct ggcgatgtat      660

cccacgctgg ggactgctcc ctgggagcga atgccgacag gggaagatga tgacattgcg      720

cgctcgttga aagcgtcgtt gctgggccgc ttgatcttga tgggtaaatt ttgtctgtta      780

gctgaggacg gcattcacta tagcgatgga ataagccatg ccggttatct ggagggcaaa      840

accgacccct cggtgtccgt cgatttttca ggaaagaaac caaaggcgtt atgggttaat      900

ccgggtaaac gcccctggcg cgaactgacg tcgttattgc agtttattga gcaagatagc      960

ccccggggat atgaaacccg tcagcttagc cttcctctga agcggataac ccatcatgcg     1020

gagcagtttg cgctatggtc aggcggctta agggtgagta gtaatgcggg ggaacagtac     1080

gcttcaggga ccgatgatta tgttcagtca gaaatatggt tgtcatcaga tttaatcaat     1140

cacacatttt tagagtattt aaaatatgaa atgacgcagc ttgatgctgt gcaaaaacag     1200

ctttggggtg cagttgtacg ttattttcgc cagctatcag atattgataa atcagcgaca     1260

gggaaggctc aaccctttgt ggcaaagcag gccgaaaaag cgacgacgat attctggcaa     1320

ctttgtgaac gtcaggctca gaccctaatt aatgcttgct tgaattccgg tgaagaccat     1380

accgcgcgtc ttcagttacg aaaaattttt gccaggtacg ccgggcaggt ttttgatcag     1440

ctctgtcccg ccgacagtgc ccgtcaatta gatgcctggg cgctggcccg gcctaatttt     1500

tcccaatatc tcaccctcga ttaa                                            1524


<210>  151
<211>  567
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(567)
<223>  Cse2

<400>  151
atggatcagg ttcctgcaga cgttaccgcc gaaagcgccg gtaacgaatc gcctgccaaa       60

cgatttgtcg gttacgtgat tgagcgtatc gcgaaagaca atggctttgc cgcccgcctt      120

aaacgagcgg ataacccggc gaccgagtat cagagctggg aaatcctggc ggggtttggc      180

attgacctgg aaaaagagtg gcaacgcctg ccgtactgcg tcattggcgc cgcgctggca      240

aaggcgaaac cggccagcaa tggcacaatc actctggggg ccgccattgc cggttgttat      300

cccgaaggca atcagtctga acaggcgaaa gctcgcctgc gacggctgtt ggcctgtact      360

tcgaccagcg aagcgtgccg tattttgcgc ccgttgttgg cattaatggc cagccgcagt      420

gtgacgccgg atttcgcagg gctactcaac gaactgcagt ggttctccgg cagcagtcgc      480

gaacggatcc gcgcccgctg ggcgcaggaa ttctatcgtc gtgccggtga ggctgccggg      540

agtgaggcga ggaattcaca tgactga                                          567


<210>  152
<211>  1035
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(1035)
<223>  Cas7

<400>  152
atgactaccc cgttcagaaa cacccgtatt gagtttcata ttctgcagtc tttcccggtg       60

acctgcctta accgcgatga cgtgggcgcc cccaagtccg ccatcgttgg cggtgtgtcg      120

cgcgccagag tgtcatcgca gtgctggaag cgccaggtgc gtctggcgct gcctgatttt      180

ggtattcgtc tcggggtgcg tagtaaaaaa actgcctcac tgctggccaa cgcctgtcgc      240

gcactgggag cgagcgaaga acaggccacc ggatgcggtg aagcgatggc cgcttttttc      300

tccgatgata ccctgctgtt tctcagcgag gctgaggccg ccgcatttgc cgcttatgcg      360

cagggaaaag attttgacgc cgccagcctg aaagacaaag agctggtcaa agtcgccaaa      420

aaggtggtta acaataccct ggatgccctg gatattgcgc ttttcgggcg catggtggcc      480

aaagcggcgg atatgaacgt tgaggcggcg gcatcgttcg cgcatgccat ttccacccat      540

aaagtgagta atgagatcga gttttttacc gccgtggatg actgtaaaac ggaggatgaa      600

agcggttcgg cacatatggg cagcctggag tttaattcgg cgacctacta tcgctatgtc      660

agcttggatc tcgggcaact ggcgcagacg ttgggtgagg acgccgatat gaaaaccgcc      720

gtcgccgctt ttgttaaggc actctatgtc gccgtcccct cagcccgaca gacaacgcag      780

tccggggcct gcccgtggga atatgcccgc gtgttactgc gtaaaggtca gggtctgcag      840

gcttcattcg agcagccagt taagagtcag ggtgaaggct tcttatctcc cagtaaagcg      900

gcgctcaaaa actggttgca tacaaaagaa aaactctctg gctccttgtt cggcaaacaa      960

ggcgattatg agtggggtga ggacctcgac tacagcattg accgcctgat cgctgactta     1020

cagtcacatc tgtaa                                                      1035


<210>  153
<211>  717
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(717)
<223>  Cas5

<400>  153
atgagacaaa ctacgcaata tatgctgctg tggcttgaag ggccgctgca gtcctggggg       60

ggcgattcaa agttcggtgt gcgcgatacg ctgaatttcc cgactcgctc gggcattctg      120

gggctgattt gctgtgcacg aggcgccgcg gggccagagg tcgagtggct ggcggagatg      180

aataacctgc cgatggaggt tcgcgcctac gcccgaaccg acaaggaggg ccagccgctc      240

ctgcgcgagc cgacattgtg cgatttccag atggttggca gcggatatga cgacagcgat      300

ccgtggcaaa gtctgctgat ccctaaaaca tccgatggaa agaaagccgt agggggtgga      360

acgaaaatga cctaccgcca ctatctccag gatgccgtat tcgccgtggt aatgggactt      420

ggcagccagc aagccgagtc gttaccagag gcgctacaaa atccggtatg ggatttatat      480

ctcggtcgta aaagctgcgt gcccagcgag ctgatctatc agggcatcta tgacagcgca      540

gaagcggcat ggcagcaggc caggacatta gctgagagta agcggcgcac gctgagttac      600

aaggtcattg aaggggaagg ggatggcgat gtcatcacgc ttaatgatgt cccggtgcag      660

ttcggccggc ataagcgtta ccgggatcgt caggtgaccg tgctggagtg cggctaa         717


<210>  154
<211>  648
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(648)
<223>  Cas6

<400>  154
atgactgacc tctttgcgag tgctttacat ctcgatcgcg ctgcggtgaa agcgctgaaa       60

ataagcgatg cctactccct acaccgggtg gtgtacagcc tgtttgctga cgcgcgtaca      120

gaccgggaga agtgcagcca tatttcgagc gggatcgcct atgccgacca gggcggggat      180

tttcatggcc gcaaaatatt gatcgtctct gacagacttc cggctgcaaa ggttgatggc      240

ctgtacggtg aggtcatcag taaatcgatt ccggccgcct ttctctccca ttcgcgttat      300

cgctttcagg tacaagtgaa tccggtacgg aaagataagc aaacgggtaa acgcgtcgcg      360

gtgaaaggcc gggccgatat tgcgcagtgg tttattcagc gagccgccag ccgctggggc      420

tttgacgttg accttcctgg cttgcaggtt gaggcgatgg aagtgctgca gtttaaagat      480

aaaggcggcc gccaggtaac gcttggcaag gcgacggtgc aggggctgct caccgtcacc      540

gaccgacaga agttccagca tagttttcat catggcattg gtaaagggcg agcctttggc      600

tgcggcctgc tgcagattgt gcccgttgtt gatgcgcttt tttcctga                   648


<210>  155
<211>  1524
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(1524)
<223>  Cas8

<400>  155
atggagaaca ggttcaatct gatcgacgag ccctggatcg ccgtggtgga tgtgggcctg       60

gtgtccctga ccgacatctt ttctcagcca gagctgcgcg ccctgggagg aaatcctgtg      120

gagaagatcg ccctgacaaa gctgctgctg gcaatcgcac aggcagcagc aacccctaca      180

gacgattccg actggcagca gatgggatgg cagggaatgg cacactgctg tctgcagtac      240

ctggccaagt ggcacgatcg gttctacctg tatggcgaga agcccttcct gcagatgcct      300

gccatccagg cagcagagtg caagtccctg ggcgtgctga gccctgaggt gtccaccggc      360

aacaccacag tgctgacaga gtctcagcag cagcagcagc tgaccgatgc cgacaaggcc      420

ctggccatcg tgatgcagat gggcttcggc ctgggcggca agaagaccga caacagcgtg      480

gtgctgacac ccggctatcg gggcaagcag aatgataagg gcaagcctgg cagcggcaag      540

gcaggcgtgt ccgtgggaca catgggcctg ctgcactcct tctggcaggg caactctatc      600

gtgcagagca tctggctgaa tctgtttacc gccgaggaca tcacacagct ggccatgtac      660

ccaaccctgg gcacagcccc atgggagaga atgcccaccg gcgaggacga tgacatcgcc      720

agatccctga aggcctctct gctgggcagg ctgatcctga tgggcaagtt ctgtctgctg      780

gccgaggatg gcatccacta cagcgacggc atctcccacg ccggctatct ggagggcaag      840

accgatccca gcgtgtccgt ggacttcagc ggcaagaagc ctaaggccct gtgggtgaat      900

ccaggcaaga gaccctggag ggagctgaca tctctgctgc agtttatcga gcaggacagc      960

ccacgcggct atgagacccg gcagctgagc ctgcccctga agagaatcac acaccacgca     1020

gagcagtttg cactgtggtc cggcggactg agggtgagct ccaacgcagg agagcagtac     1080

gccagcggca ccgatgacta tgtgcagtcc gagatctggc tgtctagcga cctgatcaat     1140

cacaccttcc tggagtacct gaagtatgag atgacacagc tggatgcagt gcagaagcag     1200

ctgtggggag cagtggtgcg ctactttcgg cagctgtccg atatcgacaa gtctgccaca     1260

ggcaaggcac agcccttcgt ggcaaagcag gcagagaagg ccaccacaat cttttggcag     1320

ctgtgcgaga ggcaggcaca gaccctgatc aacgcctgtc tgaatagcgg cgaggaccac     1380

acagccagac tgcagctgag gaagatcttt gccagatatg ccggccaggt gttcgatcag     1440

ctgtgccctg ccgactccgc caggcagctg gatgcctggg cactggcccg gccaaacttc     1500

tctcagtacc tgaccctgga ttaa                                            1524


<210>  156
<211>  567
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(567)
<223>  Cse2

<400>  156
atggatcagg tgcctgcaga cgtgacagca gagtctgccg gcaatgagag cccagccaag       60

cggttcgtgg gctatgtgat cgagcggatc gccaaggata acggatttgc agcacgcctg      120

aagagggcag acaatccagc caccgagtat cagtcctggg agatcctggc cggcttcggc      180

atcgacctgg agaaggagtg gcagcgcctg ccatactgcg tgatcggagc cgccctggca      240

aaggcaaagc ctgcctctaa cggaaccatc acactgggag cagcaatcgc aggatgttac      300

cccgagggca atcagagcga gcaggcaaag gcaaggctgc ggagactgct ggcatgcacc      360

tccacatctg aggcctgtag aatcctgagg ccactgctgg ccctgatggc aagccgctcc      420

gtgacccccg acttcgcagg actgctgaac gagctgcagt ggtttagcgg ctctagcagg      480

gagcgcatcc gggcaagatg ggcacaggag ttttatagga gggcaggaga ggcagcaggc      540

tctgaggcca gaaacagcca cgactaa                                          567


<210>  157
<211>  1035
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(1035)
<223>  Cas7

<400>  157
atgaccacac ccttccgcaa cacccggatc gagtttcaca tcctgcagag cttccctgtg       60

acatgcctga atagagacga tgtgggagca ccaaagtctg ccatcgtggg aggcgtgagc      120

cgggccagag tgagctccca gtgttggaag agacaggtga ggctggccct gcctgacttt      180

ggcatcagac tgggcgtgag gtctaagaag accgccagcc tgctggcaaa cgcctgccgg      240

gccctgggag ccagcgagga gcaggccacc ggctgtggcg aggccatggc cgccttcttt      300

tctgacgata cactgctgtt tctgagcgag gcagaggcag cagccttcgc cgcctacgcc      360

cagggcaagg attttgacgc cgccagcctg aaggacaagg agctggtgaa ggtggccaag      420

aaggtggtga acaataccct ggatgccctg gacatcgccc tgttcggcag aatggtggcc      480

aaggcagcag atatgaacgt ggaggcagca gcctcctttg cccacgcaat ctccacacac      540

aaggtgtcta atgagatcga gttctttacc gccgtggacg attgcaagac agaggacgag      600

tccggctctg cccacatggg cagcctggag ttcaactccg ccacctacta tagatacgtg      660

tccctggatc tgggacagct ggcacagacc ctgggagagg atgccgacat gaagacagcc      720

gtggccgcct ttgtgaaggc cctgtacgtg gcagtgccat ccgccagaca gaccacacag      780

tctggcgcct gtccttggga gtatgcccgc gtgctgctgc ggaagggaca gggactgcag      840

gccagcttcg agcagcctgt gaagtcccag ggcgagggct ttctgagccc atccaaggcc      900

gccctgaaga attggctgca caccaaggag aagctgtctg gcagcctgtt cggcaagcag      960

ggcgactacg agtggggcga ggatctggac tatagcatcg atcgcctgat cgcagacctg     1020

cagtcccacc tgtaa                                                      1035


<210>  158
<211>  717
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(717)
<223>  Cas5

<400>  158
atgaggcaga ccacacagta catgctgctg tggctggagg gaccactgca gtcctgggga       60

ggcgactcta agtttggcgt gagagatacc ctgaatttcc ctacaaggtc cggcatcctg      120

ggcctgatct gctgtgcaag gggagcagca ggccctgagg tggagtggct ggccgagatg      180

aacaatctgc caatggaggt gagagcctat gccaggaccg acaaggaggg acagcctctg      240

ctgagggagc caacactgtg cgatttccag atggtgggca gcggctacga cgattccgac      300

ccctggcagt ctctgctgat ccctaagacc agcgatggca agaaggcagt gggaggagga      360

accaagatga catacaggca ctatctgcag gatgccgtgt ttgcagtggt catgggactg      420

ggcagccagc aggcagagtc cctgcctgag gccctgcaga acccagtgtg ggacctgtac      480

ctgggccgga agtcttgcgt gcctagcgag ctgatctacc agggcatcta tgattccgcc      540

gaggcagcat ggcagcaggc aagaaccctg gccgagagca agcggagaac actgtcctat      600

aaagtgatcg agggcgaggg cgatggcgac gtgatcaccc tgaacgacgt gcctgtgcag      660

ttcggccgcc acaagaggta ccgcgatagg caggtcaccg tgctggagtg cggataa         717


<210>  159
<211>  648
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(648)
<223>  Cas6

<400>  159
atgaccgatc tgtttgcatc tgccctgcac ctggacaggg cagcagtgaa ggccctgaag       60

atctccgatg cctactctct gcaccgggtg gtgtatagcc tgttcgcaga tgcaaggaca      120

gacagggaga agtgctccca catctcctct ggcatcgcat acgcagatca gggaggcgac      180

tttcacggac gcaagatcct gatcgtgagc gacaggctgc cagcagcaaa ggtggatgga      240

ctgtacggcg aagtgatctc taagagcatc cctgccgcct ttctgtccca cagccggtat      300

aggttccagg tgcaagtgaa tccagtgagg aaggacaagc agaccggcaa gagagtggcc      360

gtgaagggca gggccgatat cgcacagtgg ttcatccaga gggcagcatc ccggtggggc      420

tttgatgtgg acctgccagg actgcaggtg gaggcaatgg aggtgctgca gttcaaggac      480

aagggaggcc gccaggtgac cctgggcaag gcaacagtgc agggactgct gaccgtgaca      540

gatagacaga agtttcagca ctctttccac cacggaatcg gcaagggaag ggccttcggc      600

tgcggactgc tgcagatcgt gccagtggtg gacgccctgt ttagctaa                   648


<210>  160
<211>  507
<212>  PRT
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(507)
<223>  Cas8

<400>  160

Met Glu Asn Arg Phe Asn Leu Ile Asp Glu Pro Trp Ile Ala Val Val 
1               5                   10                  15      


Asp Val Gly Leu Val Ser Leu Thr Asp Ile Phe Ser Gln Pro Glu Leu 
            20                  25                  30          


Arg Ala Leu Gly Gly Asn Pro Val Glu Lys Ile Ala Leu Thr Lys Leu 
        35                  40                  45              


Leu Leu Ala Ile Ala Gln Ala Ala Ala Thr Pro Thr Asp Asp Ser Asp 
    50                  55                  60                  


Trp Gln Gln Met Gly Trp Gln Gly Met Ala His Cys Cys Leu Gln Tyr 
65                  70                  75                  80  


Leu Ala Lys Trp His Asp Arg Phe Tyr Leu Tyr Gly Glu Lys Pro Phe 
                85                  90                  95      


Leu Gln Met Pro Ala Ile Gln Ala Ala Glu Cys Lys Ser Leu Gly Val 
            100                 105                 110         


Leu Ser Pro Glu Val Ser Thr Gly Asn Thr Thr Val Leu Thr Glu Ser 
        115                 120                 125             


Gln Gln Gln Gln Gln Leu Thr Asp Ala Asp Lys Ala Leu Ala Ile Val 
    130                 135                 140                 


Met Gln Met Gly Phe Gly Leu Gly Gly Lys Lys Thr Asp Asn Ser Val 
145                 150                 155                 160 


Val Leu Thr Pro Gly Tyr Arg Gly Lys Gln Asn Asp Lys Gly Lys Pro 
                165                 170                 175     


Gly Ser Gly Lys Ala Gly Val Ser Val Gly His Met Gly Leu Leu His 
            180                 185                 190         


Ser Phe Trp Gln Gly Asn Ser Ile Val Gln Ser Ile Trp Leu Asn Leu 
        195                 200                 205             


Phe Thr Ala Glu Asp Ile Thr Gln Leu Ala Met Tyr Pro Thr Leu Gly 
    210                 215                 220                 


Thr Ala Pro Trp Glu Arg Met Pro Thr Gly Glu Asp Asp Asp Ile Ala 
225                 230                 235                 240 


Arg Ser Leu Lys Ala Ser Leu Leu Gly Arg Leu Ile Leu Met Gly Lys 
                245                 250                 255     


Phe Cys Leu Leu Ala Glu Asp Gly Ile His Tyr Ser Asp Gly Ile Ser 
            260                 265                 270         


His Ala Gly Tyr Leu Glu Gly Lys Thr Asp Pro Ser Val Ser Val Asp 
        275                 280                 285             


Phe Ser Gly Lys Lys Pro Lys Ala Leu Trp Val Asn Pro Gly Lys Arg 
    290                 295                 300                 


Pro Trp Arg Glu Leu Thr Ser Leu Leu Gln Phe Ile Glu Gln Asp Ser 
305                 310                 315                 320 


Pro Arg Gly Tyr Glu Thr Arg Gln Leu Ser Leu Pro Leu Lys Arg Ile 
                325                 330                 335     


Thr His His Ala Glu Gln Phe Ala Leu Trp Ser Gly Gly Leu Arg Val 
            340                 345                 350         


Ser Ser Asn Ala Gly Glu Gln Tyr Ala Ser Gly Thr Asp Asp Tyr Val 
        355                 360                 365             


Gln Ser Glu Ile Trp Leu Ser Ser Asp Leu Ile Asn His Thr Phe Leu 
    370                 375                 380                 


Glu Tyr Leu Lys Tyr Glu Met Thr Gln Leu Asp Ala Val Gln Lys Gln 
385                 390                 395                 400 


Leu Trp Gly Ala Val Val Arg Tyr Phe Arg Gln Leu Ser Asp Ile Asp 
                405                 410                 415     


Lys Ser Ala Thr Gly Lys Ala Gln Pro Phe Val Ala Lys Gln Ala Glu 
            420                 425                 430         


Lys Ala Thr Thr Ile Phe Trp Gln Leu Cys Glu Arg Gln Ala Gln Thr 
        435                 440                 445             


Leu Ile Asn Ala Cys Leu Asn Ser Gly Glu Asp His Thr Ala Arg Leu 
    450                 455                 460                 


Gln Leu Arg Lys Ile Phe Ala Arg Tyr Ala Gly Gln Val Phe Asp Gln 
465                 470                 475                 480 


Leu Cys Pro Ala Asp Ser Ala Arg Gln Leu Asp Ala Trp Ala Leu Ala 
                485                 490                 495     


Arg Pro Asn Phe Ser Gln Tyr Leu Thr Leu Asp 
            500                 505         


<210>  161
<211>  188
<212>  PRT
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(188)
<223>  Cse2

<400>  161

Met Asp Gln Val Pro Ala Asp Val Thr Ala Glu Ser Ala Gly Asn Glu 
1               5                   10                  15      


Ser Pro Ala Lys Arg Phe Val Gly Tyr Val Ile Glu Arg Ile Ala Lys 
            20                  25                  30          


Asp Asn Gly Phe Ala Ala Arg Leu Lys Arg Ala Asp Asn Pro Ala Thr 
        35                  40                  45              


Glu Tyr Gln Ser Trp Glu Ile Leu Ala Gly Phe Gly Ile Asp Leu Glu 
    50                  55                  60                  


Lys Glu Trp Gln Arg Leu Pro Tyr Cys Val Ile Gly Ala Ala Leu Ala 
65                  70                  75                  80  


Lys Ala Lys Pro Ala Ser Asn Gly Thr Ile Thr Leu Gly Ala Ala Ile 
                85                  90                  95      


Ala Gly Cys Tyr Pro Glu Gly Asn Gln Ser Glu Gln Ala Lys Ala Arg 
            100                 105                 110         


Leu Arg Arg Leu Leu Ala Cys Thr Ser Thr Ser Glu Ala Cys Arg Ile 
        115                 120                 125             


Leu Arg Pro Leu Leu Ala Leu Met Ala Ser Arg Ser Val Thr Pro Asp 
    130                 135                 140                 


Phe Ala Gly Leu Leu Asn Glu Leu Gln Trp Phe Ser Gly Ser Ser Arg 
145                 150                 155                 160 


Glu Arg Ile Arg Ala Arg Trp Ala Gln Glu Phe Tyr Arg Arg Ala Gly 
                165                 170                 175     


Glu Ala Ala Gly Ser Glu Ala Arg Asn Ser His Asp 
            180                 185             


<210>  162
<211>  344
<212>  PRT
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(344)
<223>  Cas7

<400>  162

Met Thr Thr Pro Phe Arg Asn Thr Arg Ile Glu Phe His Ile Leu Gln 
1               5                   10                  15      


Ser Phe Pro Val Thr Cys Leu Asn Arg Asp Asp Val Gly Ala Pro Lys 
            20                  25                  30          


Ser Ala Ile Val Gly Gly Val Ser Arg Ala Arg Val Ser Ser Gln Cys 
        35                  40                  45              


Trp Lys Arg Gln Val Arg Leu Ala Leu Pro Asp Phe Gly Ile Arg Leu 
    50                  55                  60                  


Gly Val Arg Ser Lys Lys Thr Ala Ser Leu Leu Ala Asn Ala Cys Arg 
65                  70                  75                  80  


Ala Leu Gly Ala Ser Glu Glu Gln Ala Thr Gly Cys Gly Glu Ala Met 
                85                  90                  95      


Ala Ala Phe Phe Ser Asp Asp Thr Leu Leu Phe Leu Ser Glu Ala Glu 
            100                 105                 110         


Ala Ala Ala Phe Ala Ala Tyr Ala Gln Gly Lys Asp Phe Asp Ala Ala 
        115                 120                 125             


Ser Leu Lys Asp Lys Glu Leu Val Lys Val Ala Lys Lys Val Val Asn 
    130                 135                 140                 


Asn Thr Leu Asp Ala Leu Asp Ile Ala Leu Phe Gly Arg Met Val Ala 
145                 150                 155                 160 


Lys Ala Ala Asp Met Asn Val Glu Ala Ala Ala Ser Phe Ala His Ala 
                165                 170                 175     


Ile Ser Thr His Lys Val Ser Asn Glu Ile Glu Phe Phe Thr Ala Val 
            180                 185                 190         


Asp Asp Cys Lys Thr Glu Asp Glu Ser Gly Ser Ala His Met Gly Ser 
        195                 200                 205             


Leu Glu Phe Asn Ser Ala Thr Tyr Tyr Arg Tyr Val Ser Leu Asp Leu 
    210                 215                 220                 


Gly Gln Leu Ala Gln Thr Leu Gly Glu Asp Ala Asp Met Lys Thr Ala 
225                 230                 235                 240 


Val Ala Ala Phe Val Lys Ala Leu Tyr Val Ala Val Pro Ser Ala Arg 
                245                 250                 255     


Gln Thr Thr Gln Ser Gly Ala Cys Pro Trp Glu Tyr Ala Arg Val Leu 
            260                 265                 270         


Leu Arg Lys Gly Gln Gly Leu Gln Ala Ser Phe Glu Gln Pro Val Lys 
        275                 280                 285             


Ser Gln Gly Glu Gly Phe Leu Ser Pro Ser Lys Ala Ala Leu Lys Asn 
    290                 295                 300                 


Trp Leu His Thr Lys Glu Lys Leu Ser Gly Ser Leu Phe Gly Lys Gln 
305                 310                 315                 320 


Gly Asp Tyr Glu Trp Gly Glu Asp Leu Asp Tyr Ser Ile Asp Arg Leu 
                325                 330                 335     


Ile Ala Asp Leu Gln Ser His Leu 
            340                 


<210>  163
<211>  238
<212>  PRT
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(238)
<223>  Cas5

<400>  163

Met Arg Gln Thr Thr Gln Tyr Met Leu Leu Trp Leu Glu Gly Pro Leu 
1               5                   10                  15      


Gln Ser Trp Gly Gly Asp Ser Lys Phe Gly Val Arg Asp Thr Leu Asn 
            20                  25                  30          


Phe Pro Thr Arg Ser Gly Ile Leu Gly Leu Ile Cys Cys Ala Arg Gly 
        35                  40                  45              


Ala Ala Gly Pro Glu Val Glu Trp Leu Ala Glu Met Asn Asn Leu Pro 
    50                  55                  60                  


Met Glu Val Arg Ala Tyr Ala Arg Thr Asp Lys Glu Gly Gln Pro Leu 
65                  70                  75                  80  


Leu Arg Glu Pro Thr Leu Cys Asp Phe Gln Met Val Gly Ser Gly Tyr 
                85                  90                  95      


Asp Asp Ser Asp Pro Trp Gln Ser Leu Leu Ile Pro Lys Thr Ser Asp 
            100                 105                 110         


Gly Lys Lys Ala Val Gly Gly Gly Thr Lys Met Thr Tyr Arg His Tyr 
        115                 120                 125             


Leu Gln Asp Ala Val Phe Ala Val Val Met Gly Leu Gly Ser Gln Gln 
    130                 135                 140                 


Ala Glu Ser Leu Pro Glu Ala Leu Gln Asn Pro Val Trp Asp Leu Tyr 
145                 150                 155                 160 


Leu Gly Arg Lys Ser Cys Val Pro Ser Glu Leu Ile Tyr Gln Gly Ile 
                165                 170                 175     


Tyr Asp Ser Ala Glu Ala Ala Trp Gln Gln Ala Arg Thr Leu Ala Glu 
            180                 185                 190         


Ser Lys Arg Arg Thr Leu Ser Tyr Lys Val Ile Glu Gly Glu Gly Asp 
        195                 200                 205             


Gly Asp Val Ile Thr Leu Asn Asp Val Pro Val Gln Phe Gly Arg His 
    210                 215                 220                 


Lys Arg Tyr Arg Asp Arg Gln Val Thr Val Leu Glu Cys Gly 
225                 230                 235             


<210>  164
<211>  215
<212>  PRT
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(215)
<223>  Cas6

<400>  164

Met Thr Asp Leu Phe Ala Ser Ala Leu His Leu Asp Arg Ala Ala Val 
1               5                   10                  15      


Lys Ala Leu Lys Ile Ser Asp Ala Tyr Ser Leu His Arg Val Val Tyr 
            20                  25                  30          


Ser Leu Phe Ala Asp Ala Arg Thr Asp Arg Glu Lys Cys Ser His Ile 
        35                  40                  45              


Ser Ser Gly Ile Ala Tyr Ala Asp Gln Gly Gly Asp Phe His Gly Arg 
    50                  55                  60                  


Lys Ile Leu Ile Val Ser Asp Arg Leu Pro Ala Ala Lys Val Asp Gly 
65                  70                  75                  80  


Leu Tyr Gly Glu Val Ile Ser Lys Ser Ile Pro Ala Ala Phe Leu Ser 
                85                  90                  95      


His Ser Arg Tyr Arg Phe Gln Val Gln Val Asn Pro Val Arg Lys Asp 
            100                 105                 110         


Lys Gln Thr Gly Lys Arg Val Ala Val Lys Gly Arg Ala Asp Ile Ala 
        115                 120                 125             


Gln Trp Phe Ile Gln Arg Ala Ala Ser Arg Trp Gly Phe Asp Val Asp 
    130                 135                 140                 


Leu Pro Gly Leu Gln Val Glu Ala Met Glu Val Leu Gln Phe Lys Asp 
145                 150                 155                 160 


Lys Gly Gly Arg Gln Val Thr Leu Gly Lys Ala Thr Val Gln Gly Leu 
                165                 170                 175     


Leu Thr Val Thr Asp Arg Gln Lys Phe Gln His Ser Phe His His Gly 
            180                 185                 190         


Ile Gly Lys Gly Arg Ala Phe Gly Cys Gly Leu Leu Gln Ile Val Pro 
        195                 200                 205             


Val Val Asp Ala Leu Phe Ser 
    210                 215 


<210>  165
<211>  89
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172


<220>
<221>  misc_feature
<222>  (1)..(89)
<223>  CRISPR

<400>  165
gtcttcccca cacgcgtggg ggtgtttccg gctctttttt atctccttca tccttcgcta       60

tgtcttcccc acacgcgtgg gggtgtttc                                         89


<210>  166
<211>  1569
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(1569)
<223>  Cas8

<400>  166
atgactgaac actacaacct gctggatacc ccctggctgc cggtccgcct ggcgaacggc       60

gaggtccgcg agatggggct gctggaggtg taccgcgagg ccgagcgtat cagcgccctg      120

gcggaaaccg agccgccgag tctgattgca cagtaccgcc tgctgctggc cattacccac      180

cgggcgcttt tgctggagta cggcgcgtgg aaggatagtg gcaggctgcg ttggttccgc      240

gaggggttgc ccattgacgt cgtggaacgc tacctggagc gttggcgaga gcgtttctgg      300

ctgttccatc cacagtatcc gttcatgcaa gtcgcggcct tggctagcgc cgcggaaacc      360

tgcgacaaac agaagccctg ggcccagatt tccctggcca gcgccaacgg caatacccct      420

gtcgtgttcg accactccta tgacctggcg ccttccgcgg tgagtgcgga ccgggcgttg      480

tgcgccttgc tgggcttcct acagttcact ccgggcgggt tggtcaagac tgttcgcgat      540

tcggacaaag ccggcgcact ggccaatacg gcggcggtgg tacccctggc ggacagtctg      600

gcgaaaaccc tgtgcctggc cttgcacccg gcctcgggcg aagcagcctt cgatttgcct      660

gcctgggagc gggaagcctt gacgattccg caactggccg ccgaccccat tcttgccagc      720

gggcctaacg atcgctacac ccggcagtcg cgagcagtgt tgttgctgcc ggaggaagag      780

ggctgcgtcc gctggattcg tttcgccgcc ggccaggcgc tggccgacga tgtccaggcg      840

ccggacccca tggccagcta ccgccccggc gccaacaaca gcatggtccg gctgagcttc      900

ggtgaagggc gggtgttctg gcgcgacctg ccgagcttgc tgccggacag cgcggcggct      960

ggctcgaaac gggctgccgt tctcgactgg gcttccaacc tgcgcagcat cggcgccgat     1020

gcgccgtcct cgatgctgct ggtcgccgga ttggccagcg accaggccaa actgttgcgc     1080

tggcgctccg agaccgttgt cctgcctgcg gccctgctcg actcggaggg ctgtgccaac     1140

gaactgcgcc gttgtatccg ggaatcggaa gacctgtacg gcgaactgcg caagatcgcc     1200

gtggcaatgc tcgccgaggc gttgcccgat cctgccagca aggacacctg ggcgagggct     1260

cgtacgtcgt ttgacaacgg tccggctgcg gccacctatt tcgccttgct ggagcgctcg     1320

ttgccctcgc tcatggccct catcggcggc gataggttgg agatgctgga cgaagccgag     1380

gcgttctggc gaagccgcct gctggcagcc ctcgaggtcg cctggcaggg cgtgcgggaa     1440

ggcctgggcc tgtcggtcgc agcgttgcgt gcggaggcca aggtccggcc gcgctacctg     1500

gcgttgctgc gtcgttaccg tagcgaacgt acctcttcca ctccacttgc agaggagcag     1560

tgtgcatga                                                             1569


<210>  167
<211>  531
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(531)
<223>  Cse2

<400>  167
atgagtgctg ccgaacatcc tttcatcggc catctgcagc gcttgcagaa tgatcgcggt       60

gcgctggccg ttctacggcg cagcctgggc ttcgcgccgg gtgcctatgt gccggcctat      120

ccctatgtgg aacgcttcgt cggtgccgag aggcatgcgc aggatgcctg gcgcctggca      180

ctgtatctga ccgccggatt gttcgccagc catcccggac aggggcgggc gagcctggcg      240

atgcgcttcg gcgaactgat gaaagcgcgc aacagcgcga gcatcgaaaa gcgtttcatc      300

gccttgctgg ctgccgatgc ggaaaacctg ccggtgtatc tgcgccaggc cgtgagcctg      360

ttggcggcgg acaagctcgc cttcgactat ggcgccttgc tcgacgacct tgcccattgg      420

ctcgaccctt acctgcctgt tgcgcgcggc gacgccattc gccagcgctg ggccagggat      480

ttctacgcgg cgctggccaa cacaaccgac acctcccttc acaaggattg a               531


<210>  168
<211>  1143
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(1143)
<223>  Cas7

<400>  168
atgaatttgt tcatcgagtt ccatctgatc cagaacttcg ctccgtccaa cctcaaccgt       60

gacgataccg gagcgcccaa ggatgccatc tttggcggtc accgtcgggc tcgcgtcagc      120

agccagtgct tcaagcgtgc gatccgcctg actgcccacg agcaggagtt ggtcgcgccc      180

gaacatcgcg gcgtgcgcac caagaagctc aaggcattgc tgctggagcg gcttgccgga      240

cgcgatcccg ccgaggccga gggcaagatc gagacggcgc tggcggccgc ggggctcaag      300

ctcaaggacg atggcaagac cgaatacctg ctgtttctcg gcgaagcgga gattgccggt      360

ttcgccgcgc tgatcgagca gcgctgggat gaactgggca gcgccgcgcc ggctggcgag      420

aaaaagggca agaaggaagc caaggcgaac gtgccgacgg aagtgatcaa gcaggccagg      480

gccctgctcg acggtggcaa ggccgttgac gtggcgctgt tcgggcggat gctcgccgat      540

ctgcccgaag tcaatcagga cgcggcctgc caggtggccc atgcgatcag tacccatcgt      600

gtcgagcgcg agttcgatta cttcaccgcc gtcgacgatc gcggtggccc ggacgaaagc      660

ggcgccggca tgatcggcca ggtggagttc aattccgcca cgctgtatcg ctacgcagtg      720

gtcgacctgc gcaagttgct cggcaacctg cagaacgacg gcgagctggt gctgtcggcg      780

ctggaagcgt tcacccaggc catggtccgg gcgatcccgt cgggcaagca gaacaccttc      840

gcggcgcaca acctgccggc cttcgtcggt atctgcttgc gccacgcggg cccgctgaac      900

ctggccaacg cctttgagaa accggtcgtc gcgcgtgccg atgcctccct cagcgagcgc      960

tccgttgccg agttggcccg ccacgaccag caattggcct cggtctatgg tgacagccgc     1020

gaccgctggg cttatctgga catcagcggt gcctggccga aggagcgtgg cgagccggcc     1080

ggcaacctgc agcaactcgc cgattggctg cgcagccagg tttccagccg tctgggaggc     1140

tga                                                                   1143


<210>  169
<211>  663
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(663)
<223>  Cas5

<400>  169
atggctacct tgctgatgcg cctgcaaggg ccgatgcagt catggggcac caccagccgt       60

tttgacgagc gcgacactca gctggaaccg tcgaagtcgg gagtgcttgg cctggtctgc      120

gccgccctgg gacgtgatcg cagcgagccg ctggaggatc tggccagcct gcggatgggg      180

gtgcgcgtcg accgagaggg cattccgttg cgcgactacc agacggccac cggtgtgctg      240

gtcgccagtg gcaaggccga tccgcggcgg acagtggtca gcccgcggca ttacctggcc      300

gacgcggtct ttctggtcgg gctcgaaggg cgcgaccagg ccctgctgga gcgaatccag      360

caagccttgc gtgcaccgtt ctggccgctg tgcctgggcc gcaagagttt cgttcctggg      420

agcccggtgt ggttgcccga gggcctttct tccctggcac tggaacaggc gttgcaggcc      480

tggccacgcc tggccgaggc gcaaccgggc gaccgcggca agcccttgcg ttgcctgatc      540

gaggatgagc gcagcggggt ggtacgcctc gatcagccca tcgccccctt tgccgaacgc      600

cgtttcggcc cacgcttcgt acgctcggga gtcgcggatg tacctgacca gactgaccct      660

tga                                                                    663


<210>  170
<211>  612
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(612)
<223>  Cas6

<400>  170
atgtacctga ccagactgac ccttgatcct cgcagcgctc aggcgcgccg cgacctaggc       60

gacgcctatg agatgcaccg tactttgtcg cgggttttcg ccgacgagca ggctccggca      120

tcgcgcttcc tctggcgtct ggaggcctcg gggaatgcct ggtccactcc gaccttgctg      180

gtccaggcgg ccagcgaggg taactggtcg gtgctgcagg cgctccctgg ctacctgctg      240

ggggagccgc agagcaaatc tctggctttg cgacagtggc tggaaagcga tatctcctac      300

cgtttcagat tgttcgccaa tccgacggtg acacgccagg gcaagcgcta tgggctggtg      360

ggcgaggagc agcaactggc ttggctggca cgccagggcg agcggcacgg tttcgtggtc      420

gaggcggccc tcgtaacctt cagcgaagtg cttggcagcc gcaagaggca gacacgcatc      480

agcgtcttgc gcgccgcgtt cgaggggcgt ttgcggatca gtcgcccgga tgcctttggt      540

caggctctgg tcgctgggat aggccctgcc aaggctttcg gctgtggcct gctgagcctg      600

gcgcgtagct ga                                                          612


<210>  171
<211>  1569
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(1569)
<223>  Cas8

<400>  171
atgaccgagc actataacct gctggacaca ccatggctgc ctgtgcggct ggcaaatgga       60

gaggtgagag agatgggcct gctggaggtg tacagggagg cagagaggat ctctgccctg      120

gcagagaccg agccacccag cctgatcgcc cagtaccggc tgctgctggc catcacacac      180

agagccctgc tgctggagta tggagcatgg aaggactccg gccggctgag atggtttagg      240

gagggcctgc ctatcgatgt ggtggagcgg tacctggagc ggtggaggga gcggttttgg      300

ctgttccacc cacagtatcc cttcatgcag gtggccgccc tggcaagcgc cgcagagacc      360

tgcgataagc agaagccatg ggcacagatc agcctggcat ccgccaacgg caatacacct      420

gtggtgttcg atcactccta cgacctggcc ccatctgccg tgagcgccga ccgggccctg      480

tgcgcactgc tgggctttct gcagttcacc ccaggaggac tggtgaagac agtgcgcgac      540

agcgataagg caggcgccct ggcaaacacc gcagcagtgg tgccactggc agacagcctg      600

gcaaagacac tgtgcctggc cctgcaccca gcatccggcg aggcagcctt tgatctgcct      660

gcctgggaga gagaggccct gaccatccca cagctggcag ccgaccctat cctggcatcc      720

ggcccaaatg atcgctatac acggcagagc cgggccgtgc tgctgctgcc cgaggaggag      780

ggctgcgtgc ggtggatcag attcgcagca ggacaggccc tggcagacga tgtgcaggcc      840

cctgacccaa tggccagcta caggcctggc gccaacaatt ccatggtgcg cctgtctttt      900

ggcgaaggcc gggtgttctg gagagatctg cctagcctgc tgccagactc cgccgcagca      960

ggctctaaga gggcagccgt gctggactgg gcaagcaacc tgcgctccat cggagcagat     1020

gcacctagct ccatgctgct ggtggcagga ctggcaagcg atcaggccaa gctgctgaga     1080

tggaggtccg agaccgtggt gctgccagcc gccctgctgg actctgaggg atgcgcaaac     1140

gagctgcgga gatgtatccg ggagagcgag gatctgtatg gcgagctgag aaagatcgca     1200

gtggcaatgc tggcagaggc cctgcccgat cctgcatcta aggacacctg ggcaagggca     1260

cggaccagct tcgacaatgg accagcagca gcaacatact tcgcactgct ggagaggtcc     1320

ctgccttctc tgatggccct gatcggcggc gatcgcctgg agatgctgga cgaggcagag     1380

gccttctgga gatctaggct gctggccgcc ctggaggtgg catggcaggg cgtgcgggag     1440

ggactgggcc tgagcgtggc cgccctgaga gcagaggcaa aggtgcgccc aaggtacctg     1500

gccctgctga ggcgctatcg gagcgagaga acctctagca cacccctggc cgaggagcag     1560

tgcgcctaa                                                             1569


<210>  172
<211>  531
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(531)
<223>  Cse2

<400>  172
atgtccgccg cagagcaccc attcatcgga cacctgcaga ggctgcagaa tgacaggggc       60

gccctggccg tgctgaggcg cagcctggga tttgcacctg gagcatatgt gccagcatac      120

ccatatgtgg agcggttcgt gggagcagag agacacgcac aggatgcctg gaggctggcc      180

ctgtacctga ccgcaggact gtttgcatcc cacccaggac agggaagggc ctctctggca      240

atgaggttcg gagagctgat gaaggccagg aacagcgcct ccatcgagaa gcggttcatc      300

gccctgctgg cagcagacgc agagaatctg cccgtgtatc tgagacaggc cgtgagcctg      360

ctggcagcag ataagctggc cttcgactac ggcgccctgc tggacgatct ggcacactgg      420

ctggacccct atctgccagt ggcaaggggc gacgcaatca ggcagcggtg ggccagagac      480

ttctacgccg ccctggccaa caccacagat acctctctgc acaaggacta a               531


<210>  173
<211>  1143
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(1143)
<223>  Cas7

<400>  173
atgaacctgt ttatcgagtt ccacctgatc cagaattttg ccccatccaa cctgaatagg       60

gacgataccg gagcaccaaa ggacgcaatc tttggaggac acaggagagc cagagtgagc      120

tcccagtgct tcaagagagc catcaggctg accgcccacg agcaggagct ggtggccccc      180

gagcacaggg gcgtgcggac aaagaagctg aaggccctgc tgctggagag gctggcagga      240

cgcgatcctg cagaggcaga gggcaagatc gagaccgccc tggcagcagc aggcctgaag      300

ctgaaggacg atggcaagac agagtacctg ctgtttctgg gagaggcaga gatcgcagga      360

ttcgccgccc tgatcgagca gcggtgggac gagctgggca gcgccgcacc agccggcgag      420

aagaagggca agaaggaggc caaggccaac gtgcccaccg aagtgatcaa gcaggcaagg      480

gccctgctgg atggaggcaa ggcagtggac gtggccctgt tcggaaggat gctggccgat      540

ctgccagagg tcaatcagga cgcagcatgt caggtggcac acgcaatctc cacccacagg      600

gtggagaggg agtttgacta cttcacagca gtggacgata ggggaggccc cgatgagtct      660

ggcgcaggaa tgatcggcca ggtggagttt aacagcgcca ccctgtacag atatgcagtg      720

gtggacctgc gcaagctgct gggaaacctg cagaatgatg gagagctggt gctgtccgcc      780

ctggaggcct tcacccaggc aatggtgcgc gcaatcccat ctggcaagca gaacacattt      840

gccgcccaca atctgcctgc cttcgtggga atctgcctga ggcacgcagg accactgaac      900

ctggccaatg cctttgagaa gccagtggtg gcaagggcag acgcctccct gtctgagcgg      960

agcgtggcag agctggcaag acacgatcag cagctggcaa gcgtgtacgg cgacagccgg     1020

gatagatggg cctatctgga catctccggc gcatggccaa aggagagagg agagccagca     1080

ggaaacctgc agcagctggc cgattggctg aggtctcagg tgtctagccg cctgggagga     1140

taa                                                                   1143


<210>  174
<211>  663
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(663)
<223>  Cas5

<400>  174
atggccaccc tgctgatgag gctgcaggga ccaatgcagt cctggggaac cacatctcgg       60

ttcgacgaga gagatacaca gctggagcct tctaagagcg gcgtgctggg actggtgtgc      120

gccgccctgg gaagggatag aagcgagcca ctggaggacc tggcctccct gcggatgggc      180

gtgcgcgtgg atagggaggg catccccctg agagactatc agaccgcaac aggcgtgctg      240

gtggcatccg gcaaggccga tcccaggaga accgtggtgt ctcctcggca ctacctggcc      300

gacgccgtgt ttctggtggg cctggagggc agagatcagg ccctgctgga gagaatccag      360

caggccctga gagcaccatt ttggcctctg tgcctgggaa ggaagagctt cgtgccaggc      420

tcccccgtgt ggctgcctga gggactgtcc tctctggccc tggagcaggc cctgcaggcc      480

tggccaagac tggcagaggc acagcctggc gacaggggca agccactgag atgtctgatc      540

gaggacgaga ggagcggcgt ggtgcgcctg gatcagccta tcgcaccatt cgccgagagg      600

cgctttggac caagattcgt gaggtccggc gtggcagacg tgcccgatca gaccgaccct      660

taa                                                                    663


<210>  175
<211>  612
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(612)
<223>  Cas6

<400>  175
atgtatctga ccaggctgac cctggacccc cgcagcgccc aggcacggag agatctgggc       60

gacgcctacg agatgcacag gaccctgagc cgcgtgtttg cagacgagca ggcaccagca      120

tcccggttcc tgtggagact ggaggcctct ggcaacgcct ggagcacccc tacactgctg      180

gtgcaggcag catccgaggg aaattggtct gtgctgcagg ccctgccagg atacctgctg      240

ggagagccac agtccaagtc tctggccctg aggcagtggc tggagtctga catcagctac      300

aggtttcgcc tgttcgccaa tcccaccgtg acaaggcagg gcaagcggta cggactggtg      360

ggagaggagc agcagctggc atggctggca aggcagggcg agagacacgg ctttgtggtg      420

gaggccgccc tggtgacctt cagcgaggtg ctgggctccc ggaagagaca gacacggatc      480

tccgtgctga gagccgcctt tgagggcagg ctgcgcatct ctcgcccaga tgccttcggc      540

caggccctgg tggcaggaat cggacccgcc aaggccttcg gctgcggcct gctgtccctg      600

gcaaggagct aa                                                          612


<210>  176
<211>  522
<212>  PRT
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(522)
<223>  Cas8

<400>  176

Met Thr Glu His Tyr Asn Leu Leu Asp Thr Pro Trp Leu Pro Val Arg 
1               5                   10                  15      


Leu Ala Asn Gly Glu Val Arg Glu Met Gly Leu Leu Glu Val Tyr Arg 
            20                  25                  30          


Glu Ala Glu Arg Ile Ser Ala Leu Ala Glu Thr Glu Pro Pro Ser Leu 
        35                  40                  45              


Ile Ala Gln Tyr Arg Leu Leu Leu Ala Ile Thr His Arg Ala Leu Leu 
    50                  55                  60                  


Leu Glu Tyr Gly Ala Trp Lys Asp Ser Gly Arg Leu Arg Trp Phe Arg 
65                  70                  75                  80  


Glu Gly Leu Pro Ile Asp Val Val Glu Arg Tyr Leu Glu Arg Trp Arg 
                85                  90                  95      


Glu Arg Phe Trp Leu Phe His Pro Gln Tyr Pro Phe Met Gln Val Ala 
            100                 105                 110         


Ala Leu Ala Ser Ala Ala Glu Thr Cys Asp Lys Gln Lys Pro Trp Ala 
        115                 120                 125             


Gln Ile Ser Leu Ala Ser Ala Asn Gly Asn Thr Pro Val Val Phe Asp 
    130                 135                 140                 


His Ser Tyr Asp Leu Ala Pro Ser Ala Val Ser Ala Asp Arg Ala Leu 
145                 150                 155                 160 


Cys Ala Leu Leu Gly Phe Leu Gln Phe Thr Pro Gly Gly Leu Val Lys 
                165                 170                 175     


Thr Val Arg Asp Ser Asp Lys Ala Gly Ala Leu Ala Asn Thr Ala Ala 
            180                 185                 190         


Val Val Pro Leu Ala Asp Ser Leu Ala Lys Thr Leu Cys Leu Ala Leu 
        195                 200                 205             


His Pro Ala Ser Gly Glu Ala Ala Phe Asp Leu Pro Ala Trp Glu Arg 
    210                 215                 220                 


Glu Ala Leu Thr Ile Pro Gln Leu Ala Ala Asp Pro Ile Leu Ala Ser 
225                 230                 235                 240 


Gly Pro Asn Asp Arg Tyr Thr Arg Gln Ser Arg Ala Val Leu Leu Leu 
                245                 250                 255     


Pro Glu Glu Glu Gly Cys Val Arg Trp Ile Arg Phe Ala Ala Gly Gln 
            260                 265                 270         


Ala Leu Ala Asp Asp Val Gln Ala Pro Asp Pro Met Ala Ser Tyr Arg 
        275                 280                 285             


Pro Gly Ala Asn Asn Ser Met Val Arg Leu Ser Phe Gly Glu Gly Arg 
    290                 295                 300                 


Val Phe Trp Arg Asp Leu Pro Ser Leu Leu Pro Asp Ser Ala Ala Ala 
305                 310                 315                 320 


Gly Ser Lys Arg Ala Ala Val Leu Asp Trp Ala Ser Asn Leu Arg Ser 
                325                 330                 335     


Ile Gly Ala Asp Ala Pro Ser Ser Met Leu Leu Val Ala Gly Leu Ala 
            340                 345                 350         


Ser Asp Gln Ala Lys Leu Leu Arg Trp Arg Ser Glu Thr Val Val Leu 
        355                 360                 365             


Pro Ala Ala Leu Leu Asp Ser Glu Gly Cys Ala Asn Glu Leu Arg Arg 
    370                 375                 380                 


Cys Ile Arg Glu Ser Glu Asp Leu Tyr Gly Glu Leu Arg Lys Ile Ala 
385                 390                 395                 400 


Val Ala Met Leu Ala Glu Ala Leu Pro Asp Pro Ala Ser Lys Asp Thr 
                405                 410                 415     


Trp Ala Arg Ala Arg Thr Ser Phe Asp Asn Gly Pro Ala Ala Ala Thr 
            420                 425                 430         


Tyr Phe Ala Leu Leu Glu Arg Ser Leu Pro Ser Leu Met Ala Leu Ile 
        435                 440                 445             


Gly Gly Asp Arg Leu Glu Met Leu Asp Glu Ala Glu Ala Phe Trp Arg 
    450                 455                 460                 


Ser Arg Leu Leu Ala Ala Leu Glu Val Ala Trp Gln Gly Val Arg Glu 
465                 470                 475                 480 


Gly Leu Gly Leu Ser Val Ala Ala Leu Arg Ala Glu Ala Lys Val Arg 
                485                 490                 495     


Pro Arg Tyr Leu Ala Leu Leu Arg Arg Tyr Arg Ser Glu Arg Thr Ser 
            500                 505                 510         


Ser Thr Pro Leu Ala Glu Glu Gln Cys Ala 
        515                 520         


<210>  177
<211>  176
<212>  PRT
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(176)
<223>  Cse2

<400>  177

Met Ser Ala Ala Glu His Pro Phe Ile Gly His Leu Gln Arg Leu Gln 
1               5                   10                  15      


Asn Asp Arg Gly Ala Leu Ala Val Leu Arg Arg Ser Leu Gly Phe Ala 
            20                  25                  30          


Pro Gly Ala Tyr Val Pro Ala Tyr Pro Tyr Val Glu Arg Phe Val Gly 
        35                  40                  45              


Ala Glu Arg His Ala Gln Asp Ala Trp Arg Leu Ala Leu Tyr Leu Thr 
    50                  55                  60                  


Ala Gly Leu Phe Ala Ser His Pro Gly Gln Gly Arg Ala Ser Leu Ala 
65                  70                  75                  80  


Met Arg Phe Gly Glu Leu Met Lys Ala Arg Asn Ser Ala Ser Ile Glu 
                85                  90                  95      


Lys Arg Phe Ile Ala Leu Leu Ala Ala Asp Ala Glu Asn Leu Pro Val 
            100                 105                 110         


Tyr Leu Arg Gln Ala Val Ser Leu Leu Ala Ala Asp Lys Leu Ala Phe 
        115                 120                 125             


Asp Tyr Gly Ala Leu Leu Asp Asp Leu Ala His Trp Leu Asp Pro Tyr 
    130                 135                 140                 


Leu Pro Val Ala Arg Gly Asp Ala Ile Arg Gln Arg Trp Ala Arg Asp 
145                 150                 155                 160 


Phe Tyr Ala Ala Leu Ala Asn Thr Thr Asp Thr Ser Leu His Lys Asp 
                165                 170                 175     


<210>  178
<211>  380
<212>  PRT
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(380)
<223>  Cas7

<400>  178

Met Asn Leu Phe Ile Glu Phe His Leu Ile Gln Asn Phe Ala Pro Ser 
1               5                   10                  15      


Asn Leu Asn Arg Asp Asp Thr Gly Ala Pro Lys Asp Ala Ile Phe Gly 
            20                  25                  30          


Gly His Arg Arg Ala Arg Val Ser Ser Gln Cys Phe Lys Arg Ala Ile 
        35                  40                  45              


Arg Leu Thr Ala His Glu Gln Glu Leu Val Ala Pro Glu His Arg Gly 
    50                  55                  60                  


Val Arg Thr Lys Lys Leu Lys Ala Leu Leu Leu Glu Arg Leu Ala Gly 
65                  70                  75                  80  


Arg Asp Pro Ala Glu Ala Glu Gly Lys Ile Glu Thr Ala Leu Ala Ala 
                85                  90                  95      


Ala Gly Leu Lys Leu Lys Asp Asp Gly Lys Thr Glu Tyr Leu Leu Phe 
            100                 105                 110         


Leu Gly Glu Ala Glu Ile Ala Gly Phe Ala Ala Leu Ile Glu Gln Arg 
        115                 120                 125             


Trp Asp Glu Leu Gly Ser Ala Ala Pro Ala Gly Glu Lys Lys Gly Lys 
    130                 135                 140                 


Lys Glu Ala Lys Ala Asn Val Pro Thr Glu Val Ile Lys Gln Ala Arg 
145                 150                 155                 160 


Ala Leu Leu Asp Gly Gly Lys Ala Val Asp Val Ala Leu Phe Gly Arg 
                165                 170                 175     


Met Leu Ala Asp Leu Pro Glu Val Asn Gln Asp Ala Ala Cys Gln Val 
            180                 185                 190         


Ala His Ala Ile Ser Thr His Arg Val Glu Arg Glu Phe Asp Tyr Phe 
        195                 200                 205             


Thr Ala Val Asp Asp Arg Gly Gly Pro Asp Glu Ser Gly Ala Gly Met 
    210                 215                 220                 


Ile Gly Gln Val Glu Phe Asn Ser Ala Thr Leu Tyr Arg Tyr Ala Val 
225                 230                 235                 240 


Val Asp Leu Arg Lys Leu Leu Gly Asn Leu Gln Asn Asp Gly Glu Leu 
                245                 250                 255     


Val Leu Ser Ala Leu Glu Ala Phe Thr Gln Ala Met Val Arg Ala Ile 
            260                 265                 270         


Pro Ser Gly Lys Gln Asn Thr Phe Ala Ala His Asn Leu Pro Ala Phe 
        275                 280                 285             


Val Gly Ile Cys Leu Arg His Ala Gly Pro Leu Asn Leu Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Pro Val Val Ala Arg Ala Asp Ala Ser Leu Ser Glu Arg 
305                 310                 315                 320 


Ser Val Ala Glu Leu Ala Arg His Asp Gln Gln Leu Ala Ser Val Tyr 
                325                 330                 335     


Gly Asp Ser Arg Asp Arg Trp Ala Tyr Leu Asp Ile Ser Gly Ala Trp 
            340                 345                 350         


Pro Lys Glu Arg Gly Glu Pro Ala Gly Asn Leu Gln Gln Leu Ala Asp 
        355                 360                 365             


Trp Leu Arg Ser Gln Val Ser Ser Arg Leu Gly Gly 
    370                 375                 380 


<210>  179
<211>  220
<212>  PRT
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(220)
<223>  Cas5

<400>  179

Met Ala Thr Leu Leu Met Arg Leu Gln Gly Pro Met Gln Ser Trp Gly 
1               5                   10                  15      


Thr Thr Ser Arg Phe Asp Glu Arg Asp Thr Gln Leu Glu Pro Ser Lys 
            20                  25                  30          


Ser Gly Val Leu Gly Leu Val Cys Ala Ala Leu Gly Arg Asp Arg Ser 
        35                  40                  45              


Glu Pro Leu Glu Asp Leu Ala Ser Leu Arg Met Gly Val Arg Val Asp 
    50                  55                  60                  


Arg Glu Gly Ile Pro Leu Arg Asp Tyr Gln Thr Ala Thr Gly Val Leu 
65                  70                  75                  80  


Val Ala Ser Gly Lys Ala Asp Pro Arg Arg Thr Val Val Ser Pro Arg 
                85                  90                  95      


His Tyr Leu Ala Asp Ala Val Phe Leu Val Gly Leu Glu Gly Arg Asp 
            100                 105                 110         


Gln Ala Leu Leu Glu Arg Ile Gln Gln Ala Leu Arg Ala Pro Phe Trp 
        115                 120                 125             


Pro Leu Cys Leu Gly Arg Lys Ser Phe Val Pro Gly Ser Pro Val Trp 
    130                 135                 140                 


Leu Pro Glu Gly Leu Ser Ser Leu Ala Leu Glu Gln Ala Leu Gln Ala 
145                 150                 155                 160 


Trp Pro Arg Leu Ala Glu Ala Gln Pro Gly Asp Arg Gly Lys Pro Leu 
                165                 170                 175     


Arg Cys Leu Ile Glu Asp Glu Arg Ser Gly Val Val Arg Leu Asp Gln 
            180                 185                 190         


Pro Ile Ala Pro Phe Ala Glu Arg Arg Phe Gly Pro Arg Phe Val Arg 
        195                 200                 205             


Ser Gly Val Ala Asp Val Pro Asp Gln Thr Asp Pro 
    210                 215                 220 


<210>  180
<211>  203
<212>  PRT
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(203)
<223>  Cas6

<400>  180

Met Tyr Leu Thr Arg Leu Thr Leu Asp Pro Arg Ser Ala Gln Ala Arg 
1               5                   10                  15      


Arg Asp Leu Gly Asp Ala Tyr Glu Met His Arg Thr Leu Ser Arg Val 
            20                  25                  30          


Phe Ala Asp Glu Gln Ala Pro Ala Ser Arg Phe Leu Trp Arg Leu Glu 
        35                  40                  45              


Ala Ser Gly Asn Ala Trp Ser Thr Pro Thr Leu Leu Val Gln Ala Ala 
    50                  55                  60                  


Ser Glu Gly Asn Trp Ser Val Leu Gln Ala Leu Pro Gly Tyr Leu Leu 
65                  70                  75                  80  


Gly Glu Pro Gln Ser Lys Ser Leu Ala Leu Arg Gln Trp Leu Glu Ser 
                85                  90                  95      


Asp Ile Ser Tyr Arg Phe Arg Leu Phe Ala Asn Pro Thr Val Thr Arg 
            100                 105                 110         


Gln Gly Lys Arg Tyr Gly Leu Val Gly Glu Glu Gln Gln Leu Ala Trp 
        115                 120                 125             


Leu Ala Arg Gln Gly Glu Arg His Gly Phe Val Val Glu Ala Ala Leu 
    130                 135                 140                 


Val Thr Phe Ser Glu Val Leu Gly Ser Arg Lys Arg Gln Thr Arg Ile 
145                 150                 155                 160 


Ser Val Leu Arg Ala Ala Phe Glu Gly Arg Leu Arg Ile Ser Arg Pro 
                165                 170                 175     


Asp Ala Phe Gly Gln Ala Leu Val Ala Gly Ile Gly Pro Ala Lys Ala 
            180                 185                 190         


Phe Gly Cys Gly Leu Leu Ser Leu Ala Arg Ser 
        195                 200             


<210>  181
<211>  91
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01


<220>
<221>  misc_feature
<222>  (1)..(91)
<223>  CRISPR

<400>  181
gtgttcccca catgcgtggg gatgaaccgg gcaccatcgg cgccattgac cgcgcgctga       60

aggtgttccc cacatgcgtg gggatgaacc g                                      91


<210>  182
<211>  1668
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(1668)
<223>  Cas8

<400>  182
atgagtcggt ttaatttact tgatgaaccc tggatttctg ttatttatga cgagaaagga       60

tccacaaaag atgtttcttt acaggattta tttacaaatg ctcatcagta taaagaatta      120

gcaggagata cgaaaacaca agattttgcg gtattacgag tattgttggc tgttttgcat      180

acagtttttt cccgatttga tatagatgga aatgcttatg agtatcttac tattgatgaa      240

ggatggaatc agcttgaacc agtggatgag atggatattg agaattatga agaagctctt      300

tatgaaacat gggaaaaact ttggactaat aaaagatttc caaatattgt taatcaatac      360

ttagaaaaat ggcgagatcg cttttactta tttgaccaaa agtatccatt ttttcaggta      420

acgaaagaag atattgctgg agataaaatt agcaaagcca aaggaactag tattttgggt      480

aaaaatataa atagaattat atctgagagt ggaaataaga tagctttatt ttccccaaaa      540

gatgaagaaa ataaaaatac tctaactgcc gcagaattag ctagatggct aattacattt      600

caagggtatt caggagtatc cgataaggtc atttttggaa atgaaaaata tacaccttcg      660

aaaggatggc tatttgatat tggtgctatt tatattaaag gtaacacttt attcgaaacg      720

ttgttactaa attatatttc accgtataat gaatgtggta atgtagaaaa tattcagcga      780

ccttgctggg aacgtaaaag ttctgatatc attaaaagtt accttgatga aaaagatatt      840

accaatatag ctagtttata tactgtttgg agtaaaggaa tctatattga cccagacttt      900

aatttaaata aacctttctc ttttgatatt gtgaaattac ctgatatcaa tcatagggat      960

aattttttgg agccaatgac actttggaag tataatgttt cgggtaaaaa tagggatagc     1020

tatacaccaa agaaacatct tttgaatcag tctttatggc gatcttttgg cttgttatct     1080

ataaaagata ctgatcttca acatagaaaa cctggcgtta tcgaatggct tacatatatt     1140

gatgatataa taggaaatcg actatcaaac attgttgcaa ttagtatgca ggacgatgga     1200

aaccctcaat cacggcttcc aacggatgag gttattgact caatttttat caatgatttg     1260

gttttaacgg atttagacga gggtggttgg gttcctcgta tcaatgaagt agtagaagaa     1320

acaaaaaaaa ttatttctag aacatataaa acgtatatta atgatataaa ggaaatcaga     1380

aatatctcta atggtagtta tactcagcag atagttgaaa gtctatattt caaaatcgat     1440

caacctttcc gacaatggtt agctagcatt caaccagaag atgataaaga ttctaagata     1500

caagaatgga gagttttact gaagaaaata gttaaagctg aagcagaagt tattttacat     1560

caaggggggg cgagggatta tcttggtatc caaaaagatg ggcgaattaa gaatattgca     1620

actgcctata attcgttcga tttttggctt cgtcaacagt taaaatag                  1668


<210>  183
<211>  594
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(594)
<223>  Cse2

<400>  183
atgtcacaac atactaaaca aacagtttgg actgttacaa agaagattat tttcaaattg       60

agtaaccaaa aagaggaaac atatgataaa gctacactag caaaagttag aaaaacattg      120

gggaaaccct tgagtgaagc aacagaaata tggccaattc tgttcgaaaa tttaccagag      180

gaatttttaa gttcgtatca gcaaccaagc tatgaggaat tagctattta tacagcgctt      240

caattgtatg cattgcatca gcaaggtgtt tcaacaagtg tgatgctaga tgattctaag      300

ccctatgaaa atataggttc tgcacttggt aagcttagga aagaagatga taccacttca      360

attgatagac gattcaatac catgattacc tcatcaacgt ttgaagaact tacttatcat      420

ttaaggcatt tgatttcgct acttaaagtg gagtcaccgg tgattcaggt tgattactct      480

ggcctagcaa atgatttata ttggttttta aataatagtc aagaaaatgt ccgcctaaat      540

tgggcaagag catattataa acaaattaaa ggagaaaaaa acaatgacaa ctga            594


<210>  184
<211>  1068
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(1068)
<223>  Cas7

<400>  184
atgacaactg aacaacgatt atttttagat attcatgcta ttcaaagctt accaccttca       60

aatatgaata gagatgatac aggtagcccg aaaacagctc agtatggagg agttagaaga      120

tctcgcgtaa gttctcaagc atggaagaaa gcgatgagag agtattttaa tactcatggt      180

gatcattcaa atgttggtat tagaacaaaa gaaattgtga gatatgttgc agataaaata      240

gtagaactag atagttctat cagtattgaa gatgctttgg aaaaagccga taaagtcttg      300

atagctgctg gaatcaagaa aaaaggtgaa gttaaagcac tttattttat gggtgatagt      360

caagctaaga agttagctca agcagcctat gacaatataa cacataaaaa agagcttcaa      420

aagttggcta atgaagatcc agctattgat attgccctgt ttggtcgaat ggtagccgaa      480

gatccaactc ttaacgagga ttcttcttct caggttgcac atgccatttc cacacatcca      540

gtacaaactg aatttgattt ctttacggct gttgatgatt tagctccaga ggataatgca      600

ggggcgggta tgcttggaac tgttgagttt aattcttcta cactatatcg ctatgcaaat      660

gttgcgattc atgaattgtc aaaacaatta ggaaacaagg aatcgttgga gaatagttta      720

tctttgttca ttgaggcttt tgcaaagtca cttccaacag ggaaagtaaa tacatttgct      780

aatcaaacgc taccacagac tttaattgta acggttcgaa gtgatcgtcc ggttaatctt      840

gtcagtgcat ttgaagaacc agttaaatca atagaaggct atgttactaa atctatcgat      900

aaactcgcca aagagtttat taaggttgag aaatttgtag acaaaccact tatgaccttc      960

tatgttactt tgcatgagag cgacagtcta aaacaaattg gggaggaaaa agattcagtt     1020

tcaaaattat tggaagattt ttcagaaatg atagcccaat atatttaa                  1068


<210>  185
<211>  726
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(726)
<223>  Cas5

<400>  185
atgaagacga tattgttgaa atttgctggc cccttacaat catggggaac gagttcacat       60

tttgaaacta ggcatacaga tttttatcct tccaaaagtg cggtaattgg actacttgct      120

gctagtttag gttataggag agacgaagat gaaaaaattc aaaaattaaa tgaacttgat      180

tttgctgttc gtgtcgatca gcaaggaaat ctgttaagag acttccatgt tgcacagaag      240

tatacagaaa agggtaaatt tgatagaaat tatgttacga atcggtatta tctagaagac      300

gctgtatttg ttgtagccct ctcccataca gatgatagct ttatagatat cattaaaggt      360

gctctaaaaa atccctattt ccaacctttt atggggagaa gggcactccc aataactgca      420

gactttatct taggtgagac agatgttaat ccattagaga gcctaaaatc gctgaaatgg      480

caagcttctc tatggtttat gaaaaaatct catgataagg atgctatttc tttggaagtt      540

tatctagata gtcaattagt caacaaggat gtttatcagc tgaggcaaga ttatgttagg      600

tcattttcac aaaaagggag aagatttggt tttaggtatg aagtacgtga attaatcagt      660

gttcaaaatc ctcactattt aaataagaat acagagcata acattttcga gagtatagga      720

gattga                                                                 726


<210>  186
<211>  639
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(639)
<223>  Cas6

<400>  186
atgtacattt ctagggtaga aattgatcga tataatagac gaaaggttag agatttaacg       60

catgtaggag cttatcatgc ttgggtggaa gagagttttc catcggaatt agagcaatca      120

atccgtacaa gaaaattatg gcgaatcgat cgtattcaag gtaaggatta tcttattatt      180

gtaagtaaag aaaaacctaa tttacaaaaa cttgaaaaat atggtgttgt aggaagcgct      240

caaactaagg actatcaaca ttttttagat agcatcaaaa ctggttttcg aatgaatttt      300

agaatagtgc taaatccggt tatttcaatt acttcacccg ataaatcaaa acgaggagtt      360

gtaaaaccgc atgtgacgat taaacatcag atggactttc tagtgaaaca atctgagaaa      420

aatggcttct cattagtagg agaaagtttc tcaattgttg aacgtggtta tgaagttttt      480

cagaaaccag aaaaacccat acgactatca aaagttgttt acgaaggaac cttaactgtt      540

agtgatgata cgcttttcaa aaaaatgctg accgagggag ttggaaagaa aaaagcatat      600

ggttttggct tgatgacagt ggtaccactt gaggaatga                             639


<210>  187
<211>  1668
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(1668)
<223>  Cas8

<400>  187
atgtccaggt tcaacctgct ggatgagcca tggatctccg tgatctatga cgagaagggc       60

agcaccaagg acgtgtccct gcaggatctg tttacaaatg cccaccagta caaggagctg      120

gccggcgaca ccaagacaca ggatttcgcc gtgctgcggg tgctgctggc cgtgctgcac      180

accgtgttta gcagattcga catcgatggc aacgcctacg agtatctgac aatcgacgag      240

ggctggaatc agctggagcc tgtggacgag atggatatcg agaactacga ggaggccctg      300

tatgagacct gggagaagct gtggacaaat aagcggttcc caaacatcgt gaatcagtac      360

ctggagaagt ggcgggaccg gttctacctg ttcgatcaga agtatccctt ctttcaggtg      420

accaaggagg acatcgccgg cgataagatc agcaaggcca agggcacatc catcctgggc      480

aagaacatca atagaatcat ctctgagagc ggcaacaaga tcgccctgtt ctccccaaag      540

gacgaggaga acaagaatac cctgacagca gcagagctgg caaggtggct gatcaccttt      600

cagggctact ctggcgtgag cgacaaagtg atcttcggca acgagaagta tacacccagc      660

aagggctggc tgtttgatat cggcgccatc tacatcaagg gcaataccct gttcgagaca      720

ctgctgctga actacatctc cccatataat gagtgcggca acgtggagaa tatccagcgg      780

ccctgttggg agagaaagag ctccgatatc atcaagtctt acctggacga gaaggatatc      840

accaatatcg cctctctgta cacagtgtgg agcaagggca tctatatcga ccccgacttc      900

aacctgaata agcccttttc cttcgacatc gtgaagctgc cagacatcaa ccacagggat      960

aatttcctgg agcccatgac cctgtggaag tacaacgtgt ccggcaagaa tcgcgattct     1020

tatacaccca agaagcacct gctgaaccag tctctgtgga ggagctttgg cctgctgagc     1080

atcaaggaca ccgatctgca gcaccgcaag cctggcgtga tcgagtggct gacatacatc     1140

gacgatatca tcggcaaccg gctgagcaat atcgtggcca tctccatgca ggacgatggc     1200

aatccacaga gcagactgcc caccgacgaa gtgatcgatt ccatcttcat caacgacctg     1260

gtgctgacag acctggatga gggcggctgg gtgcccagaa tcaatgaggt ggtggaggag     1320

accaagaaga tcatctcccg gacatacaag acctatatca acgatatcaa ggagatcaga     1380

aacatctcca atggctctta cacccagcag atcgtggaga gcctgtactt caagatcgac     1440

cagcccttca gacagtggct ggcctccatc cagcctgagg acgataagga ttctaagatc     1500

caggagtgga gggtgctgct gaagaagatc gtgaaggccg aggcagaagt gatcctgcac     1560

cagggaggag ccagggatta tctgggcatc cagaaggacg gccgcatcaa gaacatcgcc     1620

accgcctaca atagctttga cttctggctg aggcagcagc tgaagtaa                  1668


<210>  188
<211>  594
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(594)
<223>  Cse2

<400>  188
atgtctcagc acaccaagca gacagtgtgg accgtgacaa agaagatcat cttcaagctg       60

tccaatcaga aggaggagac ctacgataag gccacactgg ccaaggtgcg caagaccctg      120

ggcaagcctc tgtctgaggc cacagagatc tggcctatcc tgtttgagaa cctgccagag      180

gagttcctga gctcctacca gcagccatcc tatgaggagc tggccatcta caccgccctg      240

cagctgtatg ccctgcacca gcagggcgtg tctacaagcg tgatgctgga cgattctaag      300

ccttatgaga acatcggcag cgccctgggc aagctgcgca aggaggacga taccacaagc      360

atcgacaggc gctttaatac catgatcaca tctagcacct tcgaggagct gacctaccac      420

ctgcggcacc tgatctccct gctgaaggtg gagtctccag tgatccaggt ggactactcc      480

ggcctggcca acgatctgta ttggttcctg aacaattctc aggagaacgt gaggctgaat      540

tgggcccgcg cctactataa gcagatcaag ggcgagaaga acaatgacaa ctaa            594


<210>  189
<211>  1068
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(1068)
<223>  Cas7

<400>  189
atgaccacag agcagagact gtttctggac atccacgcca tccagagcct gcccccttcc       60

aacatgaatc gggacgatac cggctcccct aagacagccc agtatggcgg cgtgcggaga      120

tctagggtga gctcccaggc ctggaagaag gccatgcgcg agtacttcaa cacccacggc      180

gatcacagca atgtgggcat caggacaaag gagatcgtgc gctatgtggc cgacaagatc      240

gtggagctgg attctagcat ctccatcgag gacgccctgg agaaggccga taaggtgctg      300

atcgccgccg gcatcaagaa gaagggcgag gtgaaggccc tgtacttcat gggcgattcc      360

caggccaaga agctggcaca ggcagcatac gacaacatca cccacaagaa ggagctgcag      420

aagctggcca atgaggaccc cgccatcgat atcgccctgt tcggaaggat ggtggcagag      480

gaccctaccc tgaacgagga ttcctctagc caggtggcac acgcaatcag cacccaccca      540

gtgcagacag agtttgattt ctttaccgca gtggacgatc tggcccccga ggacaatgca      600

ggagcaggaa tgctgggaac cgtggagttc aactcctcta cactgtaccg gtatgccaat      660

gtggccatcc acgagctgtc taagcagctg ggcaacaagg agagcctgga gaattctctg      720

agcctgttta tcgaggcctt cgccaagtcc ctgcctaccg gcaaggtgaa cacatttgcc      780

aatcagacac tgccacagac cctgatcgtg acagtgaggt ccgaccgccc agtgaacctg      840

gtgtctgcct tcgaggagcc cgtgaagagc atcgagggct atgtgaccaa gtccatcgat      900

aagctggcca aggagtttat caaggtggag aagttcgtgg acaagcccct gatgaccttt      960

tacgtgacac tgcacgagtc cgattctctg aagcagatcg gcgaggagaa ggatagcgtg     1020

tccaagctgc tggaggactt cagcgagatg atcgcacagt acatctaa                  1068


<210>  190
<211>  726
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(726)
<223>  Cas5

<400>  190
atgaagacca tcctgctgaa gtttgcagga cctctgcagt cctggggcac atcctctcac       60

tttgagacaa gacacaccga cttctatcca tccaagtctg ccgtgatcgg actgctggca      120

gccagcctgg gataccggag agacgaggat gagaagatcc agaagctgaa tgagctggac      180

ttcgccgtgc gggtggatca gcagggcaac ctgctgagag actttcacgt ggcccagaag      240

tacaccgaga agggcaagtt cgatcggaac tatgtgacaa atagatacta tctggaggac      300

gccgtgtttg tggtggccct gtcccacacc gacgattctt tcatcgatat catcaagggc      360

gccctgaaga acccctactt tcagcctttc atgggcaggc gcgccctgcc tatcaccgca      420

gactttatcc tgggcgagac agatgtgaat ccactggaga gcctgaagtc cctgaagtgg      480

caggcctctc tgtggttcat gaagaagagc cacgacaagg atgccatctc cctggaggtg      540

tacctggact ctcagctggt gaacaaggac gtgtaccagc tgcggcagga ctacgtgcgg      600

agcttcagcc agaagggccg gagattcggc tttaggtacg aggtgcgcga gctgatctcc      660

gtgcagaacc ctcactatct gaacaagaat accgagcaca atatcttcga gagcatcggc      720

gactaa                                                                 726


<210>  191
<211>  639
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(639)
<223>  Cas6

<400>  191
atgtacatca gcagggtgga gatcgatcgc tataatagga ggaaggtgcg cgacctgacc       60

cacgtgggag catatcacgc ctgggtggag gagtcttttc caagcgagct ggagcagtct      120

atcaggacac gcaagctgtg gcggatcgac agaatccagg gcaaggatta cctgatcatc      180

gtgagcaagg agaagcccaa tctgcagaag ctggagaagt acggagtggt gggcagcgcc      240

cagactaagg actatcagca cttcctggat tccatcaaga caggctttcg gatgaacttc      300

agaatcgtgc tgaatcccgt gatctccatc acctctcctg acaagagcaa gcggggcgtg      360

gtgaagcccc acgtgacaat caagcaccag atggattttc tggtgaagca gtctgagaag      420

aacggcttta gcctggtggg cgagtctttc agcatcgtgg agaggggcta tgaggtgttc      480

cagaagcctg agaagccaat ccgcctgtct aaggtggtgt acgagggcac cctgacagtg      540

agcgacgata ccctgtttaa gaagatgctg acagagggcg tgggcaagaa gaaggcctac      600

ggcttcggcc tgatgaccgt ggtgcccctg gaggagtaa                             639


<210>  192
<211>  555
<212>  PRT
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(555)
<223>  Cas8

<400>  192

Met Ser Arg Phe Asn Leu Leu Asp Glu Pro Trp Ile Ser Val Ile Tyr 
1               5                   10                  15      


Asp Glu Lys Gly Ser Thr Lys Asp Val Ser Leu Gln Asp Leu Phe Thr 
            20                  25                  30          


Asn Ala His Gln Tyr Lys Glu Leu Ala Gly Asp Thr Lys Thr Gln Asp 
        35                  40                  45              


Phe Ala Val Leu Arg Val Leu Leu Ala Val Leu His Thr Val Phe Ser 
    50                  55                  60                  


Arg Phe Asp Ile Asp Gly Asn Ala Tyr Glu Tyr Leu Thr Ile Asp Glu 
65                  70                  75                  80  


Gly Trp Asn Gln Leu Glu Pro Val Asp Glu Met Asp Ile Glu Asn Tyr 
                85                  90                  95      


Glu Glu Ala Leu Tyr Glu Thr Trp Glu Lys Leu Trp Thr Asn Lys Arg 
            100                 105                 110         


Phe Pro Asn Ile Val Asn Gln Tyr Leu Glu Lys Trp Arg Asp Arg Phe 
        115                 120                 125             


Tyr Leu Phe Asp Gln Lys Tyr Pro Phe Phe Gln Val Thr Lys Glu Asp 
    130                 135                 140                 


Ile Ala Gly Asp Lys Ile Ser Lys Ala Lys Gly Thr Ser Ile Leu Gly 
145                 150                 155                 160 


Lys Asn Ile Asn Arg Ile Ile Ser Glu Ser Gly Asn Lys Ile Ala Leu 
                165                 170                 175     


Phe Ser Pro Lys Asp Glu Glu Asn Lys Asn Thr Leu Thr Ala Ala Glu 
            180                 185                 190         


Leu Ala Arg Trp Leu Ile Thr Phe Gln Gly Tyr Ser Gly Val Ser Asp 
        195                 200                 205             


Lys Val Ile Phe Gly Asn Glu Lys Tyr Thr Pro Ser Lys Gly Trp Leu 
    210                 215                 220                 


Phe Asp Ile Gly Ala Ile Tyr Ile Lys Gly Asn Thr Leu Phe Glu Thr 
225                 230                 235                 240 


Leu Leu Leu Asn Tyr Ile Ser Pro Tyr Asn Glu Cys Gly Asn Val Glu 
                245                 250                 255     


Asn Ile Gln Arg Pro Cys Trp Glu Arg Lys Ser Ser Asp Ile Ile Lys 
            260                 265                 270         


Ser Tyr Leu Asp Glu Lys Asp Ile Thr Asn Ile Ala Ser Leu Tyr Thr 
        275                 280                 285             


Val Trp Ser Lys Gly Ile Tyr Ile Asp Pro Asp Phe Asn Leu Asn Lys 
    290                 295                 300                 


Pro Phe Ser Phe Asp Ile Val Lys Leu Pro Asp Ile Asn His Arg Asp 
305                 310                 315                 320 


Asn Phe Leu Glu Pro Met Thr Leu Trp Lys Tyr Asn Val Ser Gly Lys 
                325                 330                 335     


Asn Arg Asp Ser Tyr Thr Pro Lys Lys His Leu Leu Asn Gln Ser Leu 
            340                 345                 350         


Trp Arg Ser Phe Gly Leu Leu Ser Ile Lys Asp Thr Asp Leu Gln His 
        355                 360                 365             


Arg Lys Pro Gly Val Ile Glu Trp Leu Thr Tyr Ile Asp Asp Ile Ile 
    370                 375                 380                 


Gly Asn Arg Leu Ser Asn Ile Val Ala Ile Ser Met Gln Asp Asp Gly 
385                 390                 395                 400 


Asn Pro Gln Ser Arg Leu Pro Thr Asp Glu Val Ile Asp Ser Ile Phe 
                405                 410                 415     


Ile Asn Asp Leu Val Leu Thr Asp Leu Asp Glu Gly Gly Trp Val Pro 
            420                 425                 430         


Arg Ile Asn Glu Val Val Glu Glu Thr Lys Lys Ile Ile Ser Arg Thr 
        435                 440                 445             


Tyr Lys Thr Tyr Ile Asn Asp Ile Lys Glu Ile Arg Asn Ile Ser Asn 
    450                 455                 460                 


Gly Ser Tyr Thr Gln Gln Ile Val Glu Ser Leu Tyr Phe Lys Ile Asp 
465                 470                 475                 480 


Gln Pro Phe Arg Gln Trp Leu Ala Ser Ile Gln Pro Glu Asp Asp Lys 
                485                 490                 495     


Asp Ser Lys Ile Gln Glu Trp Arg Val Leu Leu Lys Lys Ile Val Lys 
            500                 505                 510         


Ala Glu Ala Glu Val Ile Leu His Gln Gly Gly Ala Arg Asp Tyr Leu 
        515                 520                 525             


Gly Ile Gln Lys Asp Gly Arg Ile Lys Asn Ile Ala Thr Ala Tyr Asn 
    530                 535                 540                 


Ser Phe Asp Phe Trp Leu Arg Gln Gln Leu Lys 
545                 550                 555 


<210>  193
<211>  197
<212>  PRT
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(197)
<223>  Cse2

<400>  193

Met Ser Gln His Thr Lys Gln Thr Val Trp Thr Val Thr Lys Lys Ile 
1               5                   10                  15      


Ile Phe Lys Leu Ser Asn Gln Lys Glu Glu Thr Tyr Asp Lys Ala Thr 
            20                  25                  30          


Leu Ala Lys Val Arg Lys Thr Leu Gly Lys Pro Leu Ser Glu Ala Thr 
        35                  40                  45              


Glu Ile Trp Pro Ile Leu Phe Glu Asn Leu Pro Glu Glu Phe Leu Ser 
    50                  55                  60                  


Ser Tyr Gln Gln Pro Ser Tyr Glu Glu Leu Ala Ile Tyr Thr Ala Leu 
65                  70                  75                  80  


Gln Leu Tyr Ala Leu His Gln Gln Gly Val Ser Thr Ser Val Met Leu 
                85                  90                  95      


Asp Asp Ser Lys Pro Tyr Glu Asn Ile Gly Ser Ala Leu Gly Lys Leu 
            100                 105                 110         


Arg Lys Glu Asp Asp Thr Thr Ser Ile Asp Arg Arg Phe Asn Thr Met 
        115                 120                 125             


Ile Thr Ser Ser Thr Phe Glu Glu Leu Thr Tyr His Leu Arg His Leu 
    130                 135                 140                 


Ile Ser Leu Leu Lys Val Glu Ser Pro Val Ile Gln Val Asp Tyr Ser 
145                 150                 155                 160 


Gly Leu Ala Asn Asp Leu Tyr Trp Phe Leu Asn Asn Ser Gln Glu Asn 
                165                 170                 175     


Val Arg Leu Asn Trp Ala Arg Ala Tyr Tyr Lys Gln Ile Lys Gly Glu 
            180                 185                 190         


Lys Asn Asn Asp Asn 
        195         


<210>  194
<211>  355
<212>  PRT
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(355)
<223>  Cas7

<400>  194

Met Thr Thr Glu Gln Arg Leu Phe Leu Asp Ile His Ala Ile Gln Ser 
1               5                   10                  15      


Leu Pro Pro Ser Asn Met Asn Arg Asp Asp Thr Gly Ser Pro Lys Thr 
            20                  25                  30          


Ala Gln Tyr Gly Gly Val Arg Arg Ser Arg Val Ser Ser Gln Ala Trp 
        35                  40                  45              


Lys Lys Ala Met Arg Glu Tyr Phe Asn Thr His Gly Asp His Ser Asn 
    50                  55                  60                  


Val Gly Ile Arg Thr Lys Glu Ile Val Arg Tyr Val Ala Asp Lys Ile 
65                  70                  75                  80  


Val Glu Leu Asp Ser Ser Ile Ser Ile Glu Asp Ala Leu Glu Lys Ala 
                85                  90                  95      


Asp Lys Val Leu Ile Ala Ala Gly Ile Lys Lys Lys Gly Glu Val Lys 
            100                 105                 110         


Ala Leu Tyr Phe Met Gly Asp Ser Gln Ala Lys Lys Leu Ala Gln Ala 
        115                 120                 125             


Ala Tyr Asp Asn Ile Thr His Lys Lys Glu Leu Gln Lys Leu Ala Asn 
    130                 135                 140                 


Glu Asp Pro Ala Ile Asp Ile Ala Leu Phe Gly Arg Met Val Ala Glu 
145                 150                 155                 160 


Asp Pro Thr Leu Asn Glu Asp Ser Ser Ser Gln Val Ala His Ala Ile 
                165                 170                 175     


Ser Thr His Pro Val Gln Thr Glu Phe Asp Phe Phe Thr Ala Val Asp 
            180                 185                 190         


Asp Leu Ala Pro Glu Asp Asn Ala Gly Ala Gly Met Leu Gly Thr Val 
        195                 200                 205             


Glu Phe Asn Ser Ser Thr Leu Tyr Arg Tyr Ala Asn Val Ala Ile His 
    210                 215                 220                 


Glu Leu Ser Lys Gln Leu Gly Asn Lys Glu Ser Leu Glu Asn Ser Leu 
225                 230                 235                 240 


Ser Leu Phe Ile Glu Ala Phe Ala Lys Ser Leu Pro Thr Gly Lys Val 
                245                 250                 255     


Asn Thr Phe Ala Asn Gln Thr Leu Pro Gln Thr Leu Ile Val Thr Val 
            260                 265                 270         


Arg Ser Asp Arg Pro Val Asn Leu Val Ser Ala Phe Glu Glu Pro Val 
        275                 280                 285             


Lys Ser Ile Glu Gly Tyr Val Thr Lys Ser Ile Asp Lys Leu Ala Lys 
    290                 295                 300                 


Glu Phe Ile Lys Val Glu Lys Phe Val Asp Lys Pro Leu Met Thr Phe 
305                 310                 315                 320 


Tyr Val Thr Leu His Glu Ser Asp Ser Leu Lys Gln Ile Gly Glu Glu 
                325                 330                 335     


Lys Asp Ser Val Ser Lys Leu Leu Glu Asp Phe Ser Glu Met Ile Ala 
            340                 345                 350         


Gln Tyr Ile 
        355 


<210>  195
<211>  241
<212>  PRT
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(241)
<223>  Cas5

<400>  195

Met Lys Thr Ile Leu Leu Lys Phe Ala Gly Pro Leu Gln Ser Trp Gly 
1               5                   10                  15      


Thr Ser Ser His Phe Glu Thr Arg His Thr Asp Phe Tyr Pro Ser Lys 
            20                  25                  30          


Ser Ala Val Ile Gly Leu Leu Ala Ala Ser Leu Gly Tyr Arg Arg Asp 
        35                  40                  45              


Glu Asp Glu Lys Ile Gln Lys Leu Asn Glu Leu Asp Phe Ala Val Arg 
    50                  55                  60                  


Val Asp Gln Gln Gly Asn Leu Leu Arg Asp Phe His Val Ala Gln Lys 
65                  70                  75                  80  


Tyr Thr Glu Lys Gly Lys Phe Asp Arg Asn Tyr Val Thr Asn Arg Tyr 
                85                  90                  95      


Tyr Leu Glu Asp Ala Val Phe Val Val Ala Leu Ser His Thr Asp Asp 
            100                 105                 110         


Ser Phe Ile Asp Ile Ile Lys Gly Ala Leu Lys Asn Pro Tyr Phe Gln 
        115                 120                 125             


Pro Phe Met Gly Arg Arg Ala Leu Pro Ile Thr Ala Asp Phe Ile Leu 
    130                 135                 140                 


Gly Glu Thr Asp Val Asn Pro Leu Glu Ser Leu Lys Ser Leu Lys Trp 
145                 150                 155                 160 


Gln Ala Ser Leu Trp Phe Met Lys Lys Ser His Asp Lys Asp Ala Ile 
                165                 170                 175     


Ser Leu Glu Val Tyr Leu Asp Ser Gln Leu Val Asn Lys Asp Val Tyr 
            180                 185                 190         


Gln Leu Arg Gln Asp Tyr Val Arg Ser Phe Ser Gln Lys Gly Arg Arg 
        195                 200                 205             


Phe Gly Phe Arg Tyr Glu Val Arg Glu Leu Ile Ser Val Gln Asn Pro 
    210                 215                 220                 


His Tyr Leu Asn Lys Asn Thr Glu His Asn Ile Phe Glu Ser Ile Gly 
225                 230                 235                 240 


Asp 
    


<210>  196
<211>  212
<212>  PRT
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(212)
<223>  Cas6

<400>  196

Met Tyr Ile Ser Arg Val Glu Ile Asp Arg Tyr Asn Arg Arg Lys Val 
1               5                   10                  15      


Arg Asp Leu Thr His Val Gly Ala Tyr His Ala Trp Val Glu Glu Ser 
            20                  25                  30          


Phe Pro Ser Glu Leu Glu Gln Ser Ile Arg Thr Arg Lys Leu Trp Arg 
        35                  40                  45              


Ile Asp Arg Ile Gln Gly Lys Asp Tyr Leu Ile Ile Val Ser Lys Glu 
    50                  55                  60                  


Lys Pro Asn Leu Gln Lys Leu Glu Lys Tyr Gly Val Val Gly Ser Ala 
65                  70                  75                  80  


Gln Thr Lys Asp Tyr Gln His Phe Leu Asp Ser Ile Lys Thr Gly Phe 
                85                  90                  95      


Arg Met Asn Phe Arg Ile Val Leu Asn Pro Val Ile Ser Ile Thr Ser 
            100                 105                 110         


Pro Asp Lys Ser Lys Arg Gly Val Val Lys Pro His Val Thr Ile Lys 
        115                 120                 125             


His Gln Met Asp Phe Leu Val Lys Gln Ser Glu Lys Asn Gly Phe Ser 
    130                 135                 140                 


Leu Val Gly Glu Ser Phe Ser Ile Val Glu Arg Gly Tyr Glu Val Phe 
145                 150                 155                 160 


Gln Lys Pro Glu Lys Pro Ile Arg Leu Ser Lys Val Val Tyr Glu Gly 
                165                 170                 175     


Thr Leu Thr Val Ser Asp Asp Thr Leu Phe Lys Lys Met Leu Thr Glu 
            180                 185                 190         


Gly Val Gly Lys Lys Lys Ala Tyr Gly Phe Gly Leu Met Thr Val Val 
        195                 200                 205             


Pro Leu Glu Glu 
    210         


<210>  197
<211>  89
<212>  DNA
<213>  Streptococcus thermophilus strain ND07


<220>
<221>  misc_feature
<222>  (1)..(89)
<223>  CRISPR

<400>  197
gtttttcccg cacacgcggg ggtgatccta tacctatatc aatggcctcc cacgcataag       60

cgtttttccc gcacacgcgg gggtgatcc                                         89


<210>  198
<211>  1743
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(1743)
<223>  Cas8

<400>  198
ttgcccggga agggtggggc gtcggtgaat ctgttatctg atgggtggct ttcagctgtt       60

tccgcaggtg ggggctctgg tttcgggggt ggtcctgggg cggggccggc ggagttcggt      120

gtgcgggagc ttctgctgaa tgcggagaag ttcgctgaca tcgtggtgga cctgcccacg      180

cagcgtccgg cggtgttccg gcaggtcctg ctgccgttgg tggtggacgc gttggggtgt      240

ccgaaggacg ccgaggcgtg gatggacatg ttccgggcgg gggctttcag ccctgagcag      300

cggcaggtgc tggctgatta cctggacaag caccagcatt tgttcggtct tctggatccg      360

gtggagccgt tcggtcaggt ggctgacctg cggacggcga agggggagac caaggggtcg      420

gcgttgctgg tggcgacggc ggccaccggg aacaacgtgc cgttgttctc gtcccggacg      480

gagggcgacg tactggagct gacgcccgct gaggcggcca ggtggctgct gcacacccac      540

tgctgggaca cggctgccat caagaccggc gcggtcggtg acccgatggt gaagtccggg      600

aagacgaccg gcaatccgac gggcccgctg ggtcagctcg gcgtgaccat gccggtgggg      660

tcgacgcttt tcgagacgtt gttgctcaac atcccgtacg gccaggctgg gctgtccgac      720

gacgtgccgc agtggcgacg gcgtagtacg cagggcgacg tcaaggacac tctctcgtgt      780

gcgacgcctg tgtggcagag cagaccggcg cgggggctgc tggaggcgtg gacgtggcag      840

gctcgccgga tccgtctcat ctctcaggac accgaccggg ggccgcgcat cacccgggtg      900

ctggtcgcgg ccggcgaccg tcttgaggtc agcccggaca cggaaccgca cacggcctgg      960

gtggtggaca gccccgccgg ccggcggggt aagagtcccg cgcggtctgg ggtgaagagt     1020

gcgcgtccgc gccgtcacac ggcaggccgc gccgggtggc gtggtcttga cgcgctgctg     1080

gccgtgaacg ctgtcgacca ggaccagcag gcgaccgcca cccgcagcgg ggcggtgagc     1140

agccagctgg tgcggcagct cagcgccatc agccgccgct tgcccagccg gtatccgctg     1200

cgggtcgagc tgaccgggat cgcctacggc aaccagtcgg ccgtcatcga ggacatgtac     1260

ttcgacgaga tcccgctgcc cgtggccgct ctcgacccgg aggggatcgt ctacggggcg     1320

ctgctggagg tggtcgacca ggcggaggac ctggccaagg cggtcaatca cctgtcgggg     1380

gaccttcgcc gggccgcggg cagtgaaccg atcccgtggg acaagggcca gcgtcccgga     1440

gacaccctgt tgcacgctct cgacccgatc gtgcggcgtc tgttggccgg cctgcgccag     1500

gccggcgacg acttcgaccg gtgtgagcag ggactggagg cgtgggagca caaggccggg     1560

caggccacgc tccgcgtcgc ggagggcctg ttcaattcgg cgcccgccgc cctgttcacc     1620

ggccgccgcg tcaagaagga cggcaaggag caggtctacc gtctcagcac tgccgaagcg     1680

tccttccgcc ggcggctcgc cgtgatcctc caccgccgcg ccgctgcacg tactgccggc     1740

tga                                                                   1743


<210>  199
<211>  615
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(615)
<223>  Cse2

<400>  199
gtgtccacct cacccttgtc cgctcccgtc cccggccaga gagtttcctc cctgcccagg       60

ccctactgga gcggccgtgc ggacgagcaa ggccagtggc ggacacgcgc cggggaatcc      120

ctgcgaccgc ccggggagga cctcagcgcg ctgagagccg gcctgggaaa gaaggcgttc      180

accgaacccc gcctgtggca gtactacacg acacccaccg acggccgcgt caccctcgag      240

ctggaggccg agcacgccgc gctcgccctg tacgggctgc atcagcaaag ccaggagcag      300

ccgatgcacc ggcagggtgt ccgcaccggc agggccctgc gcgccctgca ccagcggtac      360

agcgaagagg cgaccgaccg gcgggtggcg caggccgtcg gtgcgacctc ggctgcggcc      420

ttcgcctacc ggctccgcgc actggtgacg cagttgcgtt ccatcgggca gcccctggac      480

tacgaccagc tgatgcagga cctcctgcgc tggcacttcc ccgacggacg ctcccgggtc      540

cgccgcgggt ggggtcttgg ctaccacggc cgcgatcgcc agcccgacga agccccgccc      600

cccgaaggct cgtag                                                       615


<210>  200
<211>  1167
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(1167)
<223>  Cas7

<400>  200
atgtctcagc ccgccgcccg cccgccgcgc acgtacgtcg acttccacat cctgcagacg       60

gtccccccgg ccaacctcaa cagggacgac cagggcaacc ccaaggaggc ctactacggc      120

ggtgtccgcc gctctcgtgt ttcctcccag gcgtggaagc gtgccacccg cacccacttc      180

gccgagcggg tccccgagca ggacctcgcc acccgcaccc gcaggatcat cggcgccctc      240

gccgatgaca tccagaagcg cgccggcctg gaccgcccgg cagcgctgcg cctggccgac      300

gcgctgctgg cgccgttgga gctgagcggc ggcaagaaga aggacgagtc ggcctacctc      360

ctcttctacg gccggcgcca gctcgatgcc gtagccgccc tcgtcgccga ccaggcaacc      420

gaactgtccg cgctgagcga cgccgacctc gcttcccggg tgaaggagct cccggttcgt      480

gagcagttca gcacgggcca cccgatcgat gtcgcccttt tcgggcgcat ggtcgcggac      540

atccccgctc tcaaggtcga cgccgcggcg caggtcgccc atgccctgtc cacccacgcg      600

gtggagctcg agttcgacta cttcacggcc gtcgacgatg agcagaccga cgaggagacc      660

ggtgccggca tgatcggcac catcggcttc aactccgcca ccctctaccg ctacgcctcc      720

gtcggcctcc accagctcct ggacaatctc accgacgagg aagcggccct caccgccatc      780

agcgagttcg ccacgtcctt cgcgcgctcc atgcccaccg gctaccagaa ctcctttgcc      840

caccgcaccc tgcccagcct cgtcgccgtc gtcgtccgcg aagaccagcc cgtcaacctc      900

gtctccgcgt tcgaacaacc ggtggccacc ccctcgggca tcgccgccgc ctccgccgcg      960

cggctcgccg aggaacacac acgcgccacc gtcacatggg gcgacgctcc ggccttcgca     1020

gccgccaccc acgtgttcac cgaccaccag aagaccaccg ccgccctcaa cagcgcgttc     1080

ggcccctcca tccccttctc cgctctcctc gaaggcctgc acacccacct ggccggagcc     1140

ctcaagccca agcaggccgc gcagtga                                         1167


<210>  201
<211>  882
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(882)
<223>  Cas5

<400>  201
gtgaccaccg cccccacccc cgagcccgcc ggcaacacgc acccggccca cggcagcgac       60

gaaccgaccg tgctgctgct tcgcctcgcc ggccctctgc agtcctgggg cgtacgcagt      120

tccttcaacc gccgcgacac cggcgcggaa cccaccaagt ccggcgtcat cggcctgctg      180

gcggcagcgg caggacaccc ccgtgaacaa cccctgggag agctcgcgga cctgaccctc      240

ggtattcgcg tcgaccaacc aggcaccctg ctgcgcgact accacaccgt cagcgactac      300

cgaggccgcc ccctgccgca ggcaggtgtc tccgcgaaag gcatccagaa gcccacctca      360

ccggccaaac acacccacgt caccacccgc ttctacctcc aggacgcggt attcgtcgcc      420

gccctcgaag gcccccccgg cctcctcacc accctggaca gggcggtacg caaccccgcc      480

ttcccgctcg cactgggacg ccgctcctgc ccaccgaccc aacccctcag cctcggcttg      540

cgcaccaccg acatggaaac cgccctgcgc agcgagccct ggcaggcctc cgcccacacc      600

cgcgagcagt acgcccgccg cctgggccga gaacgcggcc tccaccagcc tcttcaccca      660

ggcaccatcg atcgcgcagc caccatcgaa gacccccgcg gcgacgaccg cctgcaggac      720

gcacccgtct ccttcgaccc ccaccagcgc gccttcacca gccgccaagt ccgccacacc      780

tggctggcca tccccaccgg cttcgaccac atcgacgacg accagcccca cggccaggcc      840

gacgaccccg accacgaccc tttcgccctg ctgggctggt ga                         882


<210>  202
<211>  813
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(813)
<223>  Cas6

<400>  202
atgacctacc tctcccgcat ccgcatcaat cccctccgca aggacagcag gaaactgctc       60

tccaaccccc gtgccgtaca cggcgccgtc atgggcggcc tgcccaacca caagcccgac      120

gaccgcgtcc tgtggcggat ggaccccgac aacccccacc ggccccacct cttcgtcctc      180

agcccgacac gccctgactg gacgcacatc atccaggact gcggatggcc ggacgcggac      240

ggtgaccatg ccgccgtccg cgactacacc cccctcctca gtcagctggc cgtcggccgc      300

gaattcgcct tccgcctcac cgccagcccc gtccagaaca ccgccacccc cacgaaggcg      360

acacccgccc aggccgcccg cctgaccacc cacgccgaaa acggcaaacg catccgcggc      420

ttccgcatgg gccaccgcac agcagccgcc caactcgact ggttcctcac ccggaccgac      480

cgctggggct tcgacatccc cgccacccgc tccgatcccg ccgcccccgg catccacgcc      540

cccacacccc ccaccgcccc tcgccccacc tcgccacccc gcccagaccc caaccctccc      600

tacgaagtcc gcatcaccgc ccgccaccgc cattccttcc agaagaacgg acacggagcg      660

cacgtcgtct tccgcagcgc aaccttcgaa ggccgcctgc gcatcaccga caccgaccgc      720

ttcaccacca gcctcctcac cggcctcggc ccctcccgcg cctacggctg cggcctgctc      780

accctcgccc cgctgcccgg acagcagacc tga                                   813


<210>  203
<211>  1743
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(1743)
<223>  Cas8

<400>  203
atgcctggca agggaggagc aagcgtgaac ctgctgtccg atggctggct gagcgccgtg       60

tccgccggcg gcggcagcgg ctttggagga ggacctggag caggaccagc agagttcggc      120

gtgcgcgagc tgctgctgaa tgccgagaag tttgccgaca tcgtggtgga tctgccaacc      180

cagaggcctg ccgtgttccg gcaggtgctg ctgcctctgg tggtggacgc cctgggatgt      240

ccaaaggacg cagaggcctg gatggatatg tttagggcag gagccttctc ccccgagcag      300

aggcaggtgc tggccgacta cctggataag caccagcacc tgtttggact gctggacccc      360

gtggagccat tcggccaggt ggccgacctg agaacagcaa agggagagac caagggcagc      420

gccctgctgg tggcaacagc agccaccggc aacaatgtgc ccctgtttag ctcccggaca      480

gagggcgacg tgctggagct gacccctgca gaggcagcaa gatggctgct gcacacacac      540

tgctgggata ccgcagccat caagacagga gcagtgggcg accctatggt gaagagcggc      600

aagaccaccg gaaacccaac aggacctctg ggacagctgg gagtgaccat gccagtgggc      660

tccacactgt tcgagaccct gctgctgaat atcccatacg gacaggcagg actgtctgat      720

gacgtgccac agtggaggcg ccggagcacc cagggcgacg tgaaggatac cctgtcctgt      780

gcaacacccg tgtggcagag ccggccagca aggggactgc tggaggcctg gacatggcag      840

gccagaagga tcagactgat ctcccaggac acagatcgcg gcccaaggat caccagagtg      900

ctggtggcag caggcgacag gctggaggtg tctccagata cagagcccca caccgcatgg      960

gtggtggata gcccagcagg ccggagaggc aagtctcctg cacggagcgg cgtgaagtcc     1020

gccagaccaa gaaggcacac cgcaggaagg gcaggatgga ggggcctgga cgccctgctg     1080

gccgtgaacg ccgtggacca ggatcagcag gcaacagcaa cccggagcgg cgccgtgtct     1140

agccagctgg tgagacagct gtctgccatc agccgccggc tgcctagccg gtacccactg     1200

agagtggagc tgaccggcat cgcctatggc aaccagtccg ccgtgatcga ggacatgtac     1260

ttcgatgaga tcccactgcc tgtggccgcc ctggaccccg agggcatcgt gtacggcgcc     1320

ctgctggagg tggtggacca ggccgaggat ctggccaagg ccgtgaatca cctgtccggc     1380

gacctgagaa gggcagcagg ctctgagcca atcccatggg acaagggaca gaggcctggc     1440

gataccctgc tgcacgccct ggacccaatc gtgcgccggc tgctggcagg actgaggcag     1500

gccggcgatg actttgatag gtgtgagcag ggcctggagg cctgggagca caaggcagga     1560

caggccacac tgcgggtggc agagggcctg tttaatagcg ccccagccgc cctgttcacc     1620

ggcagaaggg tgaagaagga cggcaaggag caggtgtatc gcctgtctac agcagaggcc     1680

agcttccgcc ggagactggc cgtgatcctg cacaggcgcg ccgccgcccg gaccgccggc     1740

taa                                                                   1743


<210>  204
<211>  615
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(615)
<223>  Cse2

<400>  204
atgtccacat ctccactgtc tgcccccgtg cctggccaga gagtgtctag cctgccaagg       60

ccatactggt ccggcagggc agatgagcag ggacagtggc ggaccagagc aggagagagc      120

ctgaggccac ctggagagga cctgtccgcc ctgagagcag gactgggcaa gaaggccttc      180

acagagccaa ggctgtggca gtactatacc acacccacag atggccgcgt gaccctggag      240

ctggaggcag agcacgccgc cctggccctg tacggactgc accagcagag ccaggagcag      300

ccaatgcaca ggcagggcgt gcggaccgga agagccctga gggccctgca ccagcggtac      360

tctgaggagg caacagacag gcgcgtggca caggcagtgg gagccaccag cgccgcagcc      420

tttgcctata ggctgcgcgc cctggtgacc cagctgaggt ctatcggcca gccactggat      480

tacgaccagc tgatgcagga tctgctgagg tggcacttcc ccgacggccg gagcagagtg      540

cggagaggat ggggactggg ataccacgga agggacaggc agcccgatga ggccccaccc      600

cctgagggca gctaa                                                       615


<210>  205
<211>  1167
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(1167)
<223>  Cas7

<400>  205
atgtcccagc cagcagcaag gccacctaga acatacgtgg actttcacat cctgcagacc       60

gtgccacccg ccaacctgaa tcgggacgat cagggcaacc caaaggaggc ctactatggc      120

ggcgtgcgga gatccagagt gagctcccag gcctggaaga gggcaacccg cacacacttc      180

gcagagcggg tgcccgagca ggatctggca accagaacaa ggaggatcat cggcgccctg      240

gcagacgata tccagaagag ggccggcctg gataggcctg ccgccctgag gctggcagac      300

gccctgctgg ccccactgga gctgtccggc ggcaagaaga aggacgagtc tgcctacctg      360

ctgttttatg gccggagaca gctggatgca gtggccgccc tggtggcaga ccaggcaacc      420

gagctgtctg ccctgagcga tgcagacctg gcatcccggg tgaaggagct gcccgtgaga      480

gagcagtttt ctacaggcca ccctatcgac gtggccctgt tcggcaggat ggtggccgac      540

atccctgccc tgaaggtgga tgcagcagca caggtggcac acgccctgag cacacacgcc      600

gtggagctgg agtttgatta cttcaccgcc gtggacgatg agcagacaga cgaggagacc      660

ggagcaggaa tgatcggaac catcggcttc aacagcgcca cactgtaccg ctatgcctcc      720

gtgggactgc accagctgct ggacaatctg accgatgagg aggccgccct gacagccatc      780

tccgagtttg ccacctcctt cgcccggtct atgcccacag gctatcagaa ctcttttgcc      840

cacaggaccc tgcccagcct ggtggcagtg gtggtgcgcg aggaccagcc tgtgaatctg      900

gtgagcgcct tcgagcagcc agtggccaca ccatccggca tcgcagcagc atctgccgca      960

aggctggccg aggagcacac ccgcgcaacc gtgacatggg gcgatgcacc agcctttgcc     1020

gcagcaacac acgtgttcac cgaccaccag aagaccacag ccgccctgaa cagcgccttt     1080

ggccctagca tcccattctc cgccctgctg gagggactgc acacccacct ggcaggcgcc     1140

ctgaagccta agcaggcagc acagtaa                                         1167


<210>  206
<211>  882
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(882)
<223>  Cas5

<400>  206
atgaccacag cacctacacc agagccagca ggaaataccc acccagcaca cggctccgat       60

gagcctaccg tgctgctgct gaggctggca ggaccactgc agtcttgggg cgtgagatcc      120

tcttttaaca ggagggacac aggagcagag ccaaccaagt ccggcgtgat cggactgctg      180

gcagcagcag caggacaccc tagagagcag ccactgggag agctggcaga tctgaccctg      240

ggcatcaggg tggaccagcc aggcacactg ctgagggact accacaccgt gagcgattat      300

aggggcagac ctctgccaca ggcaggcgtg tctgccaagg gcatccagaa gcccaccagc      360

cctgccaagc acacacacgt gaccacaagg ttttacctgc aggatgccgt gttcgtggcc      420

gccctggagg gacctccagg actgctgacc acactggaca gggccgtgcg gaatccagca      480

ttcccactgg ccctgggccg gagaagctgt ccacctaccc agccactgtc cctgggactg      540

cggaccacag atatggagac agccctgaga tctgagcctt ggcaggccag cgcccacacc      600

agagagcagt atgcaaggcg cctgggaagg gagaggggac tgcaccagcc tctgcaccca      660

ggaaccatcg acagggcagc aacaatcgag gaccccaggg gcgacgatag gctgcaggac      720

gcacccgtga gctttgatcc tcaccagagg gccttcacct ccagacaggt gaggcacacc      780

tggctggcca tccccacagg ctttgaccac atcgacgatg accagcctca cggacaggca      840

gatgaccccg atcacgaccc tttcgccctg ctgggatggt aa                         882


<210>  207
<211>  813
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(813)
<223>  Cas6

<400>  207
atgacatacc tgtcccggat cagaatcaac ccactgcgga aggacagccg gaagctgctg       60

agcaatccaa gggcagtgca cggagccgtg atgggaggcc tgccaaacca caagcccgat      120

gacagggtgc tgtggcgcat ggaccccgac aatcctcaca ggccacacct gtttgtgctg      180

agccccacac gccctgactg gacccacatc atccaggatt gtggctggcc agatgcagac      240

ggcgatcacg cagccgtgag agactatacc ccactgctga gccagctggc agtgggaaga      300

gagttcgcct ttaggctgac agcctccccc gtgcagaaca ccgccacacc aaccaaggca      360

accccagcac aggcagcaag gctgaccaca cacgccgaga atggcaagcg gatcagaggc      420

ttcagaatgg gacacagaac cgcagcagca cagctggatt ggtttctgac acgcaccgac      480

cggtggggct tcgatatccc tgcaacaaga tctgacccag cagcaccagg catccacgca      540

ccaacacctc caaccgcacc aaggcctaca agcccaccta gaccagatcc caacccacca      600

tacgaggtgc gcatcaccgc aaggcacaga cactcctttc agaagaatgg ccacggcgcc      660

cacgtggtgt ttcggtctgc caccttcgag ggcaggctgc gcatcacaga caccgatcgg      720

ttcaccacat ctctgctgac aggcctgggc cctagcagag cctatggatg cggactgctg      780

acactggcac ctctgccagg acagcagacc taa                                   813


<210>  208
<211>  580
<212>  PRT
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(580)
<223>  Cas8

<400>  208

Met Pro Gly Lys Gly Gly Ala Ser Val Asn Leu Leu Ser Asp Gly Trp 
1               5                   10                  15      


Leu Ser Ala Val Ser Ala Gly Gly Gly Ser Gly Phe Gly Gly Gly Pro 
            20                  25                  30          


Gly Ala Gly Pro Ala Glu Phe Gly Val Arg Glu Leu Leu Leu Asn Ala 
        35                  40                  45              


Glu Lys Phe Ala Asp Ile Val Val Asp Leu Pro Thr Gln Arg Pro Ala 
    50                  55                  60                  


Val Phe Arg Gln Val Leu Leu Pro Leu Val Val Asp Ala Leu Gly Cys 
65                  70                  75                  80  


Pro Lys Asp Ala Glu Ala Trp Met Asp Met Phe Arg Ala Gly Ala Phe 
                85                  90                  95      


Ser Pro Glu Gln Arg Gln Val Leu Ala Asp Tyr Leu Asp Lys His Gln 
            100                 105                 110         


His Leu Phe Gly Leu Leu Asp Pro Val Glu Pro Phe Gly Gln Val Ala 
        115                 120                 125             


Asp Leu Arg Thr Ala Lys Gly Glu Thr Lys Gly Ser Ala Leu Leu Val 
    130                 135                 140                 


Ala Thr Ala Ala Thr Gly Asn Asn Val Pro Leu Phe Ser Ser Arg Thr 
145                 150                 155                 160 


Glu Gly Asp Val Leu Glu Leu Thr Pro Ala Glu Ala Ala Arg Trp Leu 
                165                 170                 175     


Leu His Thr His Cys Trp Asp Thr Ala Ala Ile Lys Thr Gly Ala Val 
            180                 185                 190         


Gly Asp Pro Met Val Lys Ser Gly Lys Thr Thr Gly Asn Pro Thr Gly 
        195                 200                 205             


Pro Leu Gly Gln Leu Gly Val Thr Met Pro Val Gly Ser Thr Leu Phe 
    210                 215                 220                 


Glu Thr Leu Leu Leu Asn Ile Pro Tyr Gly Gln Ala Gly Leu Ser Asp 
225                 230                 235                 240 


Asp Val Pro Gln Trp Arg Arg Arg Ser Thr Gln Gly Asp Val Lys Asp 
                245                 250                 255     


Thr Leu Ser Cys Ala Thr Pro Val Trp Gln Ser Arg Pro Ala Arg Gly 
            260                 265                 270         


Leu Leu Glu Ala Trp Thr Trp Gln Ala Arg Arg Ile Arg Leu Ile Ser 
        275                 280                 285             


Gln Asp Thr Asp Arg Gly Pro Arg Ile Thr Arg Val Leu Val Ala Ala 
    290                 295                 300                 


Gly Asp Arg Leu Glu Val Ser Pro Asp Thr Glu Pro His Thr Ala Trp 
305                 310                 315                 320 


Val Val Asp Ser Pro Ala Gly Arg Arg Gly Lys Ser Pro Ala Arg Ser 
                325                 330                 335     


Gly Val Lys Ser Ala Arg Pro Arg Arg His Thr Ala Gly Arg Ala Gly 
            340                 345                 350         


Trp Arg Gly Leu Asp Ala Leu Leu Ala Val Asn Ala Val Asp Gln Asp 
        355                 360                 365             


Gln Gln Ala Thr Ala Thr Arg Ser Gly Ala Val Ser Ser Gln Leu Val 
    370                 375                 380                 


Arg Gln Leu Ser Ala Ile Ser Arg Arg Leu Pro Ser Arg Tyr Pro Leu 
385                 390                 395                 400 


Arg Val Glu Leu Thr Gly Ile Ala Tyr Gly Asn Gln Ser Ala Val Ile 
                405                 410                 415     


Glu Asp Met Tyr Phe Asp Glu Ile Pro Leu Pro Val Ala Ala Leu Asp 
            420                 425                 430         


Pro Glu Gly Ile Val Tyr Gly Ala Leu Leu Glu Val Val Asp Gln Ala 
        435                 440                 445             


Glu Asp Leu Ala Lys Ala Val Asn His Leu Ser Gly Asp Leu Arg Arg 
    450                 455                 460                 


Ala Ala Gly Ser Glu Pro Ile Pro Trp Asp Lys Gly Gln Arg Pro Gly 
465                 470                 475                 480 


Asp Thr Leu Leu His Ala Leu Asp Pro Ile Val Arg Arg Leu Leu Ala 
                485                 490                 495     


Gly Leu Arg Gln Ala Gly Asp Asp Phe Asp Arg Cys Glu Gln Gly Leu 
            500                 505                 510         


Glu Ala Trp Glu His Lys Ala Gly Gln Ala Thr Leu Arg Val Ala Glu 
        515                 520                 525             


Gly Leu Phe Asn Ser Ala Pro Ala Ala Leu Phe Thr Gly Arg Arg Val 
    530                 535                 540                 


Lys Lys Asp Gly Lys Glu Gln Val Tyr Arg Leu Ser Thr Ala Glu Ala 
545                 550                 555                 560 


Ser Phe Arg Arg Arg Leu Ala Val Ile Leu His Arg Arg Ala Ala Ala 
                565                 570                 575     


Arg Thr Ala Gly 
            580 


<210>  209
<211>  204
<212>  PRT
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(204)
<223>  Cse2

<400>  209

Met Ser Thr Ser Pro Leu Ser Ala Pro Val Pro Gly Gln Arg Val Ser 
1               5                   10                  15      


Ser Leu Pro Arg Pro Tyr Trp Ser Gly Arg Ala Asp Glu Gln Gly Gln 
            20                  25                  30          


Trp Arg Thr Arg Ala Gly Glu Ser Leu Arg Pro Pro Gly Glu Asp Leu 
        35                  40                  45              


Ser Ala Leu Arg Ala Gly Leu Gly Lys Lys Ala Phe Thr Glu Pro Arg 
    50                  55                  60                  


Leu Trp Gln Tyr Tyr Thr Thr Pro Thr Asp Gly Arg Val Thr Leu Glu 
65                  70                  75                  80  


Leu Glu Ala Glu His Ala Ala Leu Ala Leu Tyr Gly Leu His Gln Gln 
                85                  90                  95      


Ser Gln Glu Gln Pro Met His Arg Gln Gly Val Arg Thr Gly Arg Ala 
            100                 105                 110         


Leu Arg Ala Leu His Gln Arg Tyr Ser Glu Glu Ala Thr Asp Arg Arg 
        115                 120                 125             


Val Ala Gln Ala Val Gly Ala Thr Ser Ala Ala Ala Phe Ala Tyr Arg 
    130                 135                 140                 


Leu Arg Ala Leu Val Thr Gln Leu Arg Ser Ile Gly Gln Pro Leu Asp 
145                 150                 155                 160 


Tyr Asp Gln Leu Met Gln Asp Leu Leu Arg Trp His Phe Pro Asp Gly 
                165                 170                 175     


Arg Ser Arg Val Arg Arg Gly Trp Gly Leu Gly Tyr His Gly Arg Asp 
            180                 185                 190         


Arg Gln Pro Asp Glu Ala Pro Pro Pro Glu Gly Ser 
        195                 200                 


<210>  210
<211>  388
<212>  PRT
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(388)
<223>  Cas7

<400>  210

Met Ser Gln Pro Ala Ala Arg Pro Pro Arg Thr Tyr Val Asp Phe His 
1               5                   10                  15      


Ile Leu Gln Thr Val Pro Pro Ala Asn Leu Asn Arg Asp Asp Gln Gly 
            20                  25                  30          


Asn Pro Lys Glu Ala Tyr Tyr Gly Gly Val Arg Arg Ser Arg Val Ser 
        35                  40                  45              


Ser Gln Ala Trp Lys Arg Ala Thr Arg Thr His Phe Ala Glu Arg Val 
    50                  55                  60                  


Pro Glu Gln Asp Leu Ala Thr Arg Thr Arg Arg Ile Ile Gly Ala Leu 
65                  70                  75                  80  


Ala Asp Asp Ile Gln Lys Arg Ala Gly Leu Asp Arg Pro Ala Ala Leu 
                85                  90                  95      


Arg Leu Ala Asp Ala Leu Leu Ala Pro Leu Glu Leu Ser Gly Gly Lys 
            100                 105                 110         


Lys Lys Asp Glu Ser Ala Tyr Leu Leu Phe Tyr Gly Arg Arg Gln Leu 
        115                 120                 125             


Asp Ala Val Ala Ala Leu Val Ala Asp Gln Ala Thr Glu Leu Ser Ala 
    130                 135                 140                 


Leu Ser Asp Ala Asp Leu Ala Ser Arg Val Lys Glu Leu Pro Val Arg 
145                 150                 155                 160 


Glu Gln Phe Ser Thr Gly His Pro Ile Asp Val Ala Leu Phe Gly Arg 
                165                 170                 175     


Met Val Ala Asp Ile Pro Ala Leu Lys Val Asp Ala Ala Ala Gln Val 
            180                 185                 190         


Ala His Ala Leu Ser Thr His Ala Val Glu Leu Glu Phe Asp Tyr Phe 
        195                 200                 205             


Thr Ala Val Asp Asp Glu Gln Thr Asp Glu Glu Thr Gly Ala Gly Met 
    210                 215                 220                 


Ile Gly Thr Ile Gly Phe Asn Ser Ala Thr Leu Tyr Arg Tyr Ala Ser 
225                 230                 235                 240 


Val Gly Leu His Gln Leu Leu Asp Asn Leu Thr Asp Glu Glu Ala Ala 
                245                 250                 255     


Leu Thr Ala Ile Ser Glu Phe Ala Thr Ser Phe Ala Arg Ser Met Pro 
            260                 265                 270         


Thr Gly Tyr Gln Asn Ser Phe Ala His Arg Thr Leu Pro Ser Leu Val 
        275                 280                 285             


Ala Val Val Val Arg Glu Asp Gln Pro Val Asn Leu Val Ser Ala Phe 
    290                 295                 300                 


Glu Gln Pro Val Ala Thr Pro Ser Gly Ile Ala Ala Ala Ser Ala Ala 
305                 310                 315                 320 


Arg Leu Ala Glu Glu His Thr Arg Ala Thr Val Thr Trp Gly Asp Ala 
                325                 330                 335     


Pro Ala Phe Ala Ala Ala Thr His Val Phe Thr Asp His Gln Lys Thr 
            340                 345                 350         


Thr Ala Ala Leu Asn Ser Ala Phe Gly Pro Ser Ile Pro Phe Ser Ala 
        355                 360                 365             


Leu Leu Glu Gly Leu His Thr His Leu Ala Gly Ala Leu Lys Pro Lys 
    370                 375                 380                 


Gln Ala Ala Gln 
385             


<210>  211
<211>  293
<212>  PRT
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(293)
<223>  Cas5

<400>  211

Met Thr Thr Ala Pro Thr Pro Glu Pro Ala Gly Asn Thr His Pro Ala 
1               5                   10                  15      


His Gly Ser Asp Glu Pro Thr Val Leu Leu Leu Arg Leu Ala Gly Pro 
            20                  25                  30          


Leu Gln Ser Trp Gly Val Arg Ser Ser Phe Asn Arg Arg Asp Thr Gly 
        35                  40                  45              


Ala Glu Pro Thr Lys Ser Gly Val Ile Gly Leu Leu Ala Ala Ala Ala 
    50                  55                  60                  


Gly His Pro Arg Glu Gln Pro Leu Gly Glu Leu Ala Asp Leu Thr Leu 
65                  70                  75                  80  


Gly Ile Arg Val Asp Gln Pro Gly Thr Leu Leu Arg Asp Tyr His Thr 
                85                  90                  95      


Val Ser Asp Tyr Arg Gly Arg Pro Leu Pro Gln Ala Gly Val Ser Ala 
            100                 105                 110         


Lys Gly Ile Gln Lys Pro Thr Ser Pro Ala Lys His Thr His Val Thr 
        115                 120                 125             


Thr Arg Phe Tyr Leu Gln Asp Ala Val Phe Val Ala Ala Leu Glu Gly 
    130                 135                 140                 


Pro Pro Gly Leu Leu Thr Thr Leu Asp Arg Ala Val Arg Asn Pro Ala 
145                 150                 155                 160 


Phe Pro Leu Ala Leu Gly Arg Arg Ser Cys Pro Pro Thr Gln Pro Leu 
                165                 170                 175     


Ser Leu Gly Leu Arg Thr Thr Asp Met Glu Thr Ala Leu Arg Ser Glu 
            180                 185                 190         


Pro Trp Gln Ala Ser Ala His Thr Arg Glu Gln Tyr Ala Arg Arg Leu 
        195                 200                 205             


Gly Arg Glu Arg Gly Leu His Gln Pro Leu His Pro Gly Thr Ile Asp 
    210                 215                 220                 


Arg Ala Ala Thr Ile Glu Asp Pro Arg Gly Asp Asp Arg Leu Gln Asp 
225                 230                 235                 240 


Ala Pro Val Ser Phe Asp Pro His Gln Arg Ala Phe Thr Ser Arg Gln 
                245                 250                 255     


Val Arg His Thr Trp Leu Ala Ile Pro Thr Gly Phe Asp His Ile Asp 
            260                 265                 270         


Asp Asp Gln Pro His Gly Gln Ala Asp Asp Pro Asp His Asp Pro Phe 
        275                 280                 285             


Ala Leu Leu Gly Trp 
    290             


<210>  212
<211>  270
<212>  PRT
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(270)
<223>  Cas6

<400>  212

Met Thr Tyr Leu Ser Arg Ile Arg Ile Asn Pro Leu Arg Lys Asp Ser 
1               5                   10                  15      


Arg Lys Leu Leu Ser Asn Pro Arg Ala Val His Gly Ala Val Met Gly 
            20                  25                  30          


Gly Leu Pro Asn His Lys Pro Asp Asp Arg Val Leu Trp Arg Met Asp 
        35                  40                  45              


Pro Asp Asn Pro His Arg Pro His Leu Phe Val Leu Ser Pro Thr Arg 
    50                  55                  60                  


Pro Asp Trp Thr His Ile Ile Gln Asp Cys Gly Trp Pro Asp Ala Asp 
65                  70                  75                  80  


Gly Asp His Ala Ala Val Arg Asp Tyr Thr Pro Leu Leu Ser Gln Leu 
                85                  90                  95      


Ala Val Gly Arg Glu Phe Ala Phe Arg Leu Thr Ala Ser Pro Val Gln 
            100                 105                 110         


Asn Thr Ala Thr Pro Thr Lys Ala Thr Pro Ala Gln Ala Ala Arg Leu 
        115                 120                 125             


Thr Thr His Ala Glu Asn Gly Lys Arg Ile Arg Gly Phe Arg Met Gly 
    130                 135                 140                 


His Arg Thr Ala Ala Ala Gln Leu Asp Trp Phe Leu Thr Arg Thr Asp 
145                 150                 155                 160 


Arg Trp Gly Phe Asp Ile Pro Ala Thr Arg Ser Asp Pro Ala Ala Pro 
                165                 170                 175     


Gly Ile His Ala Pro Thr Pro Pro Thr Ala Pro Arg Pro Thr Ser Pro 
            180                 185                 190         


Pro Arg Pro Asp Pro Asn Pro Pro Tyr Glu Val Arg Ile Thr Ala Arg 
        195                 200                 205             


His Arg His Ser Phe Gln Lys Asn Gly His Gly Ala His Val Val Phe 
    210                 215                 220                 


Arg Ser Ala Thr Phe Glu Gly Arg Leu Arg Ile Thr Asp Thr Asp Arg 
225                 230                 235                 240 


Phe Thr Thr Ser Leu Leu Thr Gly Leu Gly Pro Ser Arg Ala Tyr Gly 
                245                 250                 255     


Cys Gly Leu Leu Thr Leu Ala Pro Leu Pro Gly Gln Gln Thr 
            260                 265                 270 


<210>  213
<211>  90
<212>  DNA
<213>  Streptomyces sp. S4


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  CRISPR

<400>  213
gtcggccccg cacccgcggg gatgctccaa tggccgagga cgacggcgat ctggccacgg       60

acgtcggccc cgcacccgcg gggatgctcc                                        90


<210>  214
<211>  744
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(744)
<223>  Cas6

<400>  214
atggaagttt acgaaatgaa attaaaagta aaacttaaaa aagatatttt tttaaaagat       60

gtttccacat atatcacaag atttatggat atgaatctat cagctaatcc aacaatgtac      120

aattatcata cttctaaaat ctacaaagga tatacatttg acggactatt cccgatagaa      180

gaagataaaa tatataaaaa agataaaact tattctttta gagtaagaac aataaatcaa      240

aaaatagcta actatttttt agatactctt atgttctttg aaaataaaga tattcaaggt      300

ttgacattaa atataagggt gatagagaaa aaattaattg aaaagttata tacaataact      360

cctattttaa tgaaaacaga tgagggatat tggagatatt ctatgacttt tgaagaattt      420

gaaaaaagat taaaaataaa ctgtttaaag aagtatttat actttacaga gaataatgat      480

gatataacta ttgatactga acttttaaaa aaattaggag aagataaatc tgatgatata      540

gatttattta ctaatattaa gtttattaat agaatgcctg tcccaattat ttataaggga      600

agaaaattag ttggagataa ggttgaacta caagttgcca ataatgagaa agcacaagat      660

attgcatata tgcttttagg aacagggctt ttagaaaatt gtgcaagggg ttgcggcttc      720

ttgaatttca aaaattatga gtag                                             744


<210>  215
<211>  1728
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(1728)
<223>  Cas8

<400>  215
ttgattgatg aagcattaga agtatttaaa aaaatttatg ataaggaggg ggaaaaactt       60

gttgtaaaca aacatattcc aaaagatgga acatatattt tagtaaatat aaaatcagga      120

aaaataatag aaaaattaaa tattttctat gataaaaaaa gtaaaaaaat agatggtgaa      180

cttaatcaat actatggcta ttttagagct tttgattatt attctaattt agtagatatg      240

aataaaccaa tggatccaaa aaagacaata cattcaaatc agatttattc attttttata      300

aaaaaagata gcataagaga aaataaatta actaaatcaa ttattgaagg atataaaaaa      360

aatcttttaa acccagaaga aaaatacaat agtaaggaag ggaaagagct atataaaaat      420

atagcagaaa agcttcctaa aattgaaaaa gatattgtag aggatatttt tttatggata      480

gaagataatg taaatgaaaa tttattagaa aatgacaata aaaaagatta cttaaaaata      540

ttttttgtag aagaggattt agataaaagt ttagaactat ttaaaaatga acataaaaga      600

tatattattc ctaatatttt taattctaat gattataata aaaaaattgg agagactatt      660

tatggattgt ctaataataa tatgggatta aatgcaaaaa aagcattttt ggaaaataag      720

acaagaagag tatcaacccc atatttagtt aatactgatg aaatactttt acaatatgct      780

ttctataatt atttattacc agaagtaaaa caaggaaatt attttattta tttttcagaa      840

aatgaaatta ttcctaggac atataaagaa ggctgtccta atggagcaaa atatttatta      900

aatgctagtt attcaaaaga tgttgatata aaaaatttta atgtaatctc aaaaaatagt      960

agcgaagaaa taaatattaa ttttaaagaa attttacatc aaaagaaaaa agatacagat     1020

gagattgaat atggaaatct taatagagaa aagatgatga ataatataaa taaaattctt     1080

ttctataatt ctttattagg aaatttttta ctcagtgatg gagatttgga tataaaggat     1140

attgagataa aaaaactgtt aatgaaatat agaaatgctt tttataagtg gttttattta     1200

aatgatgaag cagaagtcaa aaaaaatatt agaaaaatat atctggatgc tgtaatggtg     1260

gcaataggaa atggatattt ctttaaagca agtcaacaac ttgattttgg cttttgtttg     1320

gaaaagtatt tttatggaaa aagtgagtta atggaggaaa ttatgaatgt aaaagaagta     1380

tttttaaatc atactttatc agaagaagat tgggagtttt taaatgatga agagtatttt     1440

ttcgcagttg ggcaaatatt agcgtacata aattatatga gaaatagtaa agctaaaagt     1500

ttgaatttta taaaacaact aacttttgtt aaaaatattg atgttctaaa agaaaagata     1560

aagaaaatag taatttcata ttcacatatt tttgaaacta aaaataaaaa aattaataga     1620

acagtatcaa atattagttt gtaccaacca aaagaaataa gaatagatat attattagca     1680

ggatttacag cagatataat tttctttaaa aagagggagg aaaaataa                  1728


<210>  216
<211>  948
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(948)
<223>  Cas7

<400>  216
atgaaaatgg aaaaaagagt ttatggaatt ttaggaatat catctattat gtctaattgg       60

aatgcagatt tcagtggaga gcctaagtca atttctaatg gaagaatatt tgggagtgat      120

aaggcattta agtatcctat gaaaaaaatg tgggaaaatc aaggagaaaa agttctttat      180

ataaaatctt taaaagttga taaaggagct ttaattccta agactttaaa ggaaagatat      240

gagcaattat ttccagaaaa aaaacttgat aaaaatacag aaacaataga agttattaag      300

aacttattta aagccataga tgtaaaaaat tttggagcaa catttgcaga agaaggaaat      360

aatatttcta tcacaggggc agttcaaata ggacaaggtt ttaatttcta tgatgaaagt      420

aacacagaag ttcaagatat tctatctcca tttagagatc caaaaggaaa aattaataaa      480

gaaacaaaag aaaatgaaga tgcaaagaac tctactttgg gaactaaaat agttagtgat      540

gaggcacact atttttatcc ttttaatata aatcctttgg catataaaga atttatagaa      600

ttagaaataa ctgatggata tacagaagaa gattatttga agtttaaaga agcagcttta      660

tcatcagcaa ctttttttgc aacaaattca aaagttggct gtgataatga atttggacta      720

ttcattgaaa cagaagaaga tttttattta ccaattttaa ctcaatatat aaaatttgaa      780

aagggagaag aaaaaaataa aataactctt aatttaagta ctatattaaa aggagtagaa      840

aatcatatca aaaatataga aatatactat aatccagtaa ctactgaaat tgtaactgat      900

atttctaact ataagttgat aaatatttta actaagaaag aggtataa                   948


<210>  217
<211>  771
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(771)
<223>  Cas5

<400>  217
atggaagcac tgaaatttac tttaagtggt aatagtgcct tttttaaaga taatgtaatc       60

aacactgttt atttaacata tggaaatata catagagtag ctttattagg aatgtttgga      120

gcaattttag gctatggtgg atatagtaaa caaaatgata tgttgaagaa aaaaaataaa      180

aagatgcctg attatccaga attttatgag aaactaaaag atattaaaat atcaatagtt      240

tccaacggaa aaaatggtta ttttaataaa aagttacaaa catttaataa tagtgttggt      300

tatgcgtcaa aagaagaagg tggaaattta atagtaaaac aattctggtt agaaaatcct      360

tcttgggata tttatatatt gttagattgt gatgaagcaa agaaaatagc agactatata      420

cagaatagga aagctattta tcttccatat cttggaagca atgaccattt agcaaatata      480

atggatgtag agataataga tattgaagaa aagatgagtt cagaagatga aactattgaa      540

attctttcta tggtaaaaga tagtgatata tcagaaaaaa agaaaaatgt atttagtata      600

gataaaaatt caataagaga tgatatatat aaatattctg aatatttacc agttacctta      660

tcaaaagaat taaatcaata tgaaaaagaa aaaatgacaa ttactaatat gtctgttata      720

ttaaaaaaat cttattataa agtggaagat aaaaacattg ttttctatta a               771


<210>  218
<211>  744
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(744)
<223>  Cas6

<400>  218
atggaggtgt acgagatgaa gctgaaggtg aagctgaaga aggatatctt tctgaaggac       60

gtgagcacct atatcacaag attcatggat atgaacctgt ccgccaatcc aaccatgtac      120

aactatcaca catctaagat ctacaagggc tatacctttg acggcctgtt ccccatcgag      180

gaggataaga tctacaagaa ggacaagacc tatagctttc gggtgagaac aatcaaccag      240

aagatcgcca attacttcct ggataccctg atgttctttg agaataagga catccagggc      300

ctgacactga acatcagagt gatcgagaag aagctgatcg agaagctgta caccatcaca      360

cctatcctga tgaagaccga tgagggctac tggcggtatt ctatgacatt tgaggagttc      420

gagaagagac tgaagatcaa ctgcctgaag aagtacctgt atttcaccga gaacaatgac      480

gatatcacca tcgacacaga gctgctgaag aagctgggcg aggataagag cgacgatatc      540

gacctgttta caaacatcaa gttcatcaat aggatgcccg tgcctatcat ctacaagggc      600

cgcaagctgg tgggcgataa ggtggagctg caggtggcca acaatgagaa ggcccaggac      660

atcgcctata tgctgctggg aaccggactg ctggagaatt gcgcacgggg ctgtggcttt      720

ctgaacttca agaattacga gtaa                                             744


<210>  219
<211>  1728
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(1728)
<223>  Cas8

<400>  219
atgatcgatg aggccctgga ggtgtttaag aagatctacg acaaggaggg cgagaagctg       60

gtggtgaata agcacatccc caaggacggc acatatatcc tggtgaatat caagtctggc      120

aagatcatcg agaagctgaa catcttctac gataagaaga gcaagaagat cgacggcgag      180

ctgaaccagt actatggcta ttttcgcgcc ttcgattact atagcaacct ggtggatatg      240

aataagccta tggacccaaa gaagaccatc cacagcaatc agatctattc cttctttatc      300

aagaaggact ctatccggga gaacaagctg acaaagagca tcatcgaggg ctacaagaag      360

aacctgctga atcctgagga gaagtacaat tccaaggagg gcaaggagct gtataagaac      420

atcgccgaga agctgccaaa gatcgagaag gatatcgtgg aggacatctt cctgtggatc      480

gaggacaatg tgaacgagaa tctgctggag aacgataata agaaggacta tctgaagatc      540

ttctttgtgg aggaggacct ggataagagc ctggagctgt ttaagaacga gcacaagagg      600

tacatcatcc ctaacatctt caactccaac gattacaata agaagatcgg cgagaccatc      660

tatggcctgt ctaacaataa catgggcctg aacgccaaga aggcctttct ggagaataag      720

accaggcgcg tgagcacacc ctacctggtg aatacagacg agatcctgct gcagtatgcc      780

ttctacaact atctgctgcc tgaggtgaag cagggcaact actttatcta tttctccgag      840

aatgagatca tcccaagaac ctacaaggag ggctgcccca acggcgccaa gtacctgctg      900

aatgcctctt atagcaagga cgtggatatc aagaacttta atgtgatctc caagaatagc      960

tccgaggaga tcaacatcaa tttcaaggag atcctgcacc agaagaagaa ggacacagat     1020

gagatcgagt acggcaacct gaatagggag aagatgatga acaacatcaa caagatcctg     1080

ttttataact ccctgctggg caatttcctg ctgtctgacg gcgatctgga catcaaggat     1140

atcgagatca agaagctgct gatgaagtac cgcaatgcct tttacaagtg gttctatctg     1200

aacgatgagg ccgaggtgaa gaagaatatc agaaagatct acctggacgc cgtgatggtg     1260

gccatcggca acggctattt ctttaaggcc agccagcagc tggactttgg cttctgtctg     1320

gagaagtact tctatggcaa gtccgagctg atggaggaga tcatgaacgt gaaagaggtg     1380

tttctgaatc acaccctgag cgaggaggat tgggagttcc tgaacgacga ggagtacttc     1440

tttgccgtgg gccagatcct ggcctacatc aactatatgc gcaattccaa ggccaagagc     1500

ctgaacttca tcaagcagct gacattcgtg aagaacatcg acgtgctgaa ggagaagatc     1560

aagaagatcg tgatctccta ttctcacatc tttgagacca agaacaagaa gatcaatagg     1620

acagtgtcta acatcagcct gtaccagcca aaggagatcc gcatcgatat cctgctggcc     1680

ggcttcaccg ccgacatcat cttctttaag aagcgggagg agaagtaa                  1728


<210>  220
<211>  942
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(942)
<223>  Cas7

<400>  220
atggagaaga gagtgtacgg catcctgggc atcagctcca tcatgtccaa ttggaacgcc       60

gatttctctg gcgagcctaa gtctatcagc aatggcagaa tctttggctc cgacaaggcc      120

ttcaagtacc caatgaagaa gatgtgggag aaccagggcg agaaggtgct gtatatcaag      180

tctctgaagg tggataaggg cgccctgatc cccaagaccc tgaaggagag gtacgagcag      240

ctgtttcctg agaagaagct ggataagaac accgagacaa tcgaagtgat caagaatctg      300

ttcaaggcca tcgacgtgaa gaactttggc gccaccttcg ccgaggaggg caacaatatc      360

agcatcacag gcgccgtgca gatcggccag ggcttcaact tttacgacga gagcaatacc      420

gaggtgcagg atatcctgtc ccccttcaga gaccctaagg gcaagatcaa caaggagaca      480

aaggagaacg aggatgccaa gaatagcacc ctgggcacaa agatcgtgtc cgacgaggcc      540

cactactttt atccattcaa tatcaacccc ctggcctaca aggagtttat cgagctggag      600

atcaccgatg gctacacaga ggaggactat ctgaagttca aggaggccgc cctgtctagc      660

gccaccttct ttgccacaaa ctccaaagtg ggctgcgata atgagtttgg cctgttcatc      720

gagaccgagg aggactttta cctgccaatc ctgacacagt atatcaagtt cgagaagggc      780

gaggagaaga acaagatcac cctgaatctg tctacaatcc tgaagggcgt ggagaaccac      840

atcaagaata tcgagatcta ctataatccc gtgaccacag agatcgtgac cgatatcagc      900

aactacaagc tgatcaatat cctgacaaag aaggaagtgt aa                         942


<210>  221
<211>  771
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(771)
<223>  Cas5

<400>  221
atggaggccc tgaagtttac actgagcggc aattccgcct tctttaagga caacgtgatc       60

aataccgtgt acctgacata tggcaacatc cacagggtgg ccctgctggg catgtttggc      120

gccatcctgg gctacggcgg ctattctaag cagaacgaca tgctgaagaa gaagaacaag      180

aagatgccag attaccccga gttctatgag aagctgaagg acatcaagat ctctatcgtg      240

agcaacggca agaatggcta ctttaataag aagctgcaga ccttcaacaa tagcgtgggc      300

tatgcctcca aggaggaggg cggcaatctg atcgtgaagc agttctggct ggagaacccc      360

tcctgggata tctacatcct gctggactgc gatgaggcca agaagatcgc cgactatatc      420

cagaaccgca aggccatcta cctgccttat ctgggctcca acgatcacct ggccaatatc      480

atggatgtgg agatcatcga catcgaggag aagatgtcct ctgaggacga gaccatcgag      540

atcctgtcta tggtgaagga ctccgatatc tctgagaaga agaagaacgt gttcagcatc      600

gacaaaaata gcatccggga cgatatctac aagtattctg agtacctgcc tgtgacactg      660

agcaaggagc tgaatcagta tgagaaggag aagatgacca tcacaaacat gagcgtgatc      720

ctgaagaagt cctactataa ggtggaggat aagaatatcg tgttctacta a               771


<210>  222
<211>  247
<212>  PRT
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(247)
<223>  Cas6

<400>  222

Met Glu Val Tyr Glu Met Lys Leu Lys Val Lys Leu Lys Lys Asp Ile 
1               5                   10                  15      


Phe Leu Lys Asp Val Ser Thr Tyr Ile Thr Arg Phe Met Asp Met Asn 
            20                  25                  30          


Leu Ser Ala Asn Pro Thr Met Tyr Asn Tyr His Thr Ser Lys Ile Tyr 
        35                  40                  45              


Lys Gly Tyr Thr Phe Asp Gly Leu Phe Pro Ile Glu Glu Asp Lys Ile 
    50                  55                  60                  


Tyr Lys Lys Asp Lys Thr Tyr Ser Phe Arg Val Arg Thr Ile Asn Gln 
65                  70                  75                  80  


Lys Ile Ala Asn Tyr Phe Leu Asp Thr Leu Met Phe Phe Glu Asn Lys 
                85                  90                  95      


Asp Ile Gln Gly Leu Thr Leu Asn Ile Arg Val Ile Glu Lys Lys Leu 
            100                 105                 110         


Ile Glu Lys Leu Tyr Thr Ile Thr Pro Ile Leu Met Lys Thr Asp Glu 
        115                 120                 125             


Gly Tyr Trp Arg Tyr Ser Met Thr Phe Glu Glu Phe Glu Lys Arg Leu 
    130                 135                 140                 


Lys Ile Asn Cys Leu Lys Lys Tyr Leu Tyr Phe Thr Glu Asn Asn Asp 
145                 150                 155                 160 


Asp Ile Thr Ile Asp Thr Glu Leu Leu Lys Lys Leu Gly Glu Asp Lys 
                165                 170                 175     


Ser Asp Asp Ile Asp Leu Phe Thr Asn Ile Lys Phe Ile Asn Arg Met 
            180                 185                 190         


Pro Val Pro Ile Ile Tyr Lys Gly Arg Lys Leu Val Gly Asp Lys Val 
        195                 200                 205             


Glu Leu Gln Val Ala Asn Asn Glu Lys Ala Gln Asp Ile Ala Tyr Met 
    210                 215                 220                 


Leu Leu Gly Thr Gly Leu Leu Glu Asn Cys Ala Arg Gly Cys Gly Phe 
225                 230                 235                 240 


Leu Asn Phe Lys Asn Tyr Glu 
                245         


<210>  223
<211>  575
<212>  PRT
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(575)
<223>  Cas8

<400>  223

Met Ile Asp Glu Ala Leu Glu Val Phe Lys Lys Ile Tyr Asp Lys Glu 
1               5                   10                  15      


Gly Glu Lys Leu Val Val Asn Lys His Ile Pro Lys Asp Gly Thr Tyr 
            20                  25                  30          


Ile Leu Val Asn Ile Lys Ser Gly Lys Ile Ile Glu Lys Leu Asn Ile 
        35                  40                  45              


Phe Tyr Asp Lys Lys Ser Lys Lys Ile Asp Gly Glu Leu Asn Gln Tyr 
    50                  55                  60                  


Tyr Gly Tyr Phe Arg Ala Phe Asp Tyr Tyr Ser Asn Leu Val Asp Met 
65                  70                  75                  80  


Asn Lys Pro Met Asp Pro Lys Lys Thr Ile His Ser Asn Gln Ile Tyr 
                85                  90                  95      


Ser Phe Phe Ile Lys Lys Asp Ser Ile Arg Glu Asn Lys Leu Thr Lys 
            100                 105                 110         


Ser Ile Ile Glu Gly Tyr Lys Lys Asn Leu Leu Asn Pro Glu Glu Lys 
        115                 120                 125             


Tyr Asn Ser Lys Glu Gly Lys Glu Leu Tyr Lys Asn Ile Ala Glu Lys 
    130                 135                 140                 


Leu Pro Lys Ile Glu Lys Asp Ile Val Glu Asp Ile Phe Leu Trp Ile 
145                 150                 155                 160 


Glu Asp Asn Val Asn Glu Asn Leu Leu Glu Asn Asp Asn Lys Lys Asp 
                165                 170                 175     


Tyr Leu Lys Ile Phe Phe Val Glu Glu Asp Leu Asp Lys Ser Leu Glu 
            180                 185                 190         


Leu Phe Lys Asn Glu His Lys Arg Tyr Ile Ile Pro Asn Ile Phe Asn 
        195                 200                 205             


Ser Asn Asp Tyr Asn Lys Lys Ile Gly Glu Thr Ile Tyr Gly Leu Ser 
    210                 215                 220                 


Asn Asn Asn Met Gly Leu Asn Ala Lys Lys Ala Phe Leu Glu Asn Lys 
225                 230                 235                 240 


Thr Arg Arg Val Ser Thr Pro Tyr Leu Val Asn Thr Asp Glu Ile Leu 
                245                 250                 255     


Leu Gln Tyr Ala Phe Tyr Asn Tyr Leu Leu Pro Glu Val Lys Gln Gly 
            260                 265                 270         


Asn Tyr Phe Ile Tyr Phe Ser Glu Asn Glu Ile Ile Pro Arg Thr Tyr 
        275                 280                 285             


Lys Glu Gly Cys Pro Asn Gly Ala Lys Tyr Leu Leu Asn Ala Ser Tyr 
    290                 295                 300                 


Ser Lys Asp Val Asp Ile Lys Asn Phe Asn Val Ile Ser Lys Asn Ser 
305                 310                 315                 320 


Ser Glu Glu Ile Asn Ile Asn Phe Lys Glu Ile Leu His Gln Lys Lys 
                325                 330                 335     


Lys Asp Thr Asp Glu Ile Glu Tyr Gly Asn Leu Asn Arg Glu Lys Met 
            340                 345                 350         


Met Asn Asn Ile Asn Lys Ile Leu Phe Tyr Asn Ser Leu Leu Gly Asn 
        355                 360                 365             


Phe Leu Leu Ser Asp Gly Asp Leu Asp Ile Lys Asp Ile Glu Ile Lys 
    370                 375                 380                 


Lys Leu Leu Met Lys Tyr Arg Asn Ala Phe Tyr Lys Trp Phe Tyr Leu 
385                 390                 395                 400 


Asn Asp Glu Ala Glu Val Lys Lys Asn Ile Arg Lys Ile Tyr Leu Asp 
                405                 410                 415     


Ala Val Met Val Ala Ile Gly Asn Gly Tyr Phe Phe Lys Ala Ser Gln 
            420                 425                 430         


Gln Leu Asp Phe Gly Phe Cys Leu Glu Lys Tyr Phe Tyr Gly Lys Ser 
        435                 440                 445             


Glu Leu Met Glu Glu Ile Met Asn Val Lys Glu Val Phe Leu Asn His 
    450                 455                 460                 


Thr Leu Ser Glu Glu Asp Trp Glu Phe Leu Asn Asp Glu Glu Tyr Phe 
465                 470                 475                 480 


Phe Ala Val Gly Gln Ile Leu Ala Tyr Ile Asn Tyr Met Arg Asn Ser 
                485                 490                 495     


Lys Ala Lys Ser Leu Asn Phe Ile Lys Gln Leu Thr Phe Val Lys Asn 
            500                 505                 510         


Ile Asp Val Leu Lys Glu Lys Ile Lys Lys Ile Val Ile Ser Tyr Ser 
        515                 520                 525             


His Ile Phe Glu Thr Lys Asn Lys Lys Ile Asn Arg Thr Val Ser Asn 
    530                 535                 540                 


Ile Ser Leu Tyr Gln Pro Lys Glu Ile Arg Ile Asp Ile Leu Leu Ala 
545                 550                 555                 560 


Gly Phe Thr Ala Asp Ile Ile Phe Phe Lys Lys Arg Glu Glu Lys 
                565                 570                 575 


<210>  224
<211>  313
<212>  PRT
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(313)
<223>  Cas7

<400>  224

Met Glu Lys Arg Val Tyr Gly Ile Leu Gly Ile Ser Ser Ile Met Ser 
1               5                   10                  15      


Asn Trp Asn Ala Asp Phe Ser Gly Glu Pro Lys Ser Ile Ser Asn Gly 
            20                  25                  30          


Arg Ile Phe Gly Ser Asp Lys Ala Phe Lys Tyr Pro Met Lys Lys Met 
        35                  40                  45              


Trp Glu Asn Gln Gly Glu Lys Val Leu Tyr Ile Lys Ser Leu Lys Val 
    50                  55                  60                  


Asp Lys Gly Ala Leu Ile Pro Lys Thr Leu Lys Glu Arg Tyr Glu Gln 
65                  70                  75                  80  


Leu Phe Pro Glu Lys Lys Leu Asp Lys Asn Thr Glu Thr Ile Glu Val 
                85                  90                  95      


Ile Lys Asn Leu Phe Lys Ala Ile Asp Val Lys Asn Phe Gly Ala Thr 
            100                 105                 110         


Phe Ala Glu Glu Gly Asn Asn Ile Ser Ile Thr Gly Ala Val Gln Ile 
        115                 120                 125             


Gly Gln Gly Phe Asn Phe Tyr Asp Glu Ser Asn Thr Glu Val Gln Asp 
    130                 135                 140                 


Ile Leu Ser Pro Phe Arg Asp Pro Lys Gly Lys Ile Asn Lys Glu Thr 
145                 150                 155                 160 


Lys Glu Asn Glu Asp Ala Lys Asn Ser Thr Leu Gly Thr Lys Ile Val 
                165                 170                 175     


Ser Asp Glu Ala His Tyr Phe Tyr Pro Phe Asn Ile Asn Pro Leu Ala 
            180                 185                 190         


Tyr Lys Glu Phe Ile Glu Leu Glu Ile Thr Asp Gly Tyr Thr Glu Glu 
        195                 200                 205             


Asp Tyr Leu Lys Phe Lys Glu Ala Ala Leu Ser Ser Ala Thr Phe Phe 
    210                 215                 220                 


Ala Thr Asn Ser Lys Val Gly Cys Asp Asn Glu Phe Gly Leu Phe Ile 
225                 230                 235                 240 


Glu Thr Glu Glu Asp Phe Tyr Leu Pro Ile Leu Thr Gln Tyr Ile Lys 
                245                 250                 255     


Phe Glu Lys Gly Glu Glu Lys Asn Lys Ile Thr Leu Asn Leu Ser Thr 
            260                 265                 270         


Ile Leu Lys Gly Val Glu Asn His Ile Lys Asn Ile Glu Ile Tyr Tyr 
        275                 280                 285             


Asn Pro Val Thr Thr Glu Ile Val Thr Asp Ile Ser Asn Tyr Lys Leu 
    290                 295                 300                 


Ile Asn Ile Leu Thr Lys Lys Glu Val 
305                 310             


<210>  225
<211>  256
<212>  PRT
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(256)
<223>  Cas5

<400>  225

Met Glu Ala Leu Lys Phe Thr Leu Ser Gly Asn Ser Ala Phe Phe Lys 
1               5                   10                  15      


Asp Asn Val Ile Asn Thr Val Tyr Leu Thr Tyr Gly Asn Ile His Arg 
            20                  25                  30          


Val Ala Leu Leu Gly Met Phe Gly Ala Ile Leu Gly Tyr Gly Gly Tyr 
        35                  40                  45              


Ser Lys Gln Asn Asp Met Leu Lys Lys Lys Asn Lys Lys Met Pro Asp 
    50                  55                  60                  


Tyr Pro Glu Phe Tyr Glu Lys Leu Lys Asp Ile Lys Ile Ser Ile Val 
65                  70                  75                  80  


Ser Asn Gly Lys Asn Gly Tyr Phe Asn Lys Lys Leu Gln Thr Phe Asn 
                85                  90                  95      


Asn Ser Val Gly Tyr Ala Ser Lys Glu Glu Gly Gly Asn Leu Ile Val 
            100                 105                 110         


Lys Gln Phe Trp Leu Glu Asn Pro Ser Trp Asp Ile Tyr Ile Leu Leu 
        115                 120                 125             


Asp Cys Asp Glu Ala Lys Lys Ile Ala Asp Tyr Ile Gln Asn Arg Lys 
    130                 135                 140                 


Ala Ile Tyr Leu Pro Tyr Leu Gly Ser Asn Asp His Leu Ala Asn Ile 
145                 150                 155                 160 


Met Asp Val Glu Ile Ile Asp Ile Glu Glu Lys Met Ser Ser Glu Asp 
                165                 170                 175     


Glu Thr Ile Glu Ile Leu Ser Met Val Lys Asp Ser Asp Ile Ser Glu 
            180                 185                 190         


Lys Lys Lys Asn Val Phe Ser Ile Asp Lys Asn Ser Ile Arg Asp Asp 
        195                 200                 205             


Ile Tyr Lys Tyr Ser Glu Tyr Leu Pro Val Thr Leu Ser Lys Glu Leu 
    210                 215                 220                 


Asn Gln Tyr Glu Lys Glu Lys Met Thr Ile Thr Asn Met Ser Val Ile 
225                 230                 235                 240 


Leu Lys Lys Ser Tyr Tyr Lys Val Glu Asp Lys Asn Ile Val Phe Tyr 
                245                 250                 255     


<210>  226
<211>  96
<212>  DNA
<213>  Fusobacterium nucleatum subsp. animalis 3_1_33


<220>
<221>  misc_feature
<222>  (1)..(96)
<223>  CRISPR

<400>  226
atgaactgta aacttgaaaa gttttgaaat gttgacaaat attcagataa tttttcaaaa       60

tcttttatga actgtaaact tgaaaagttt tgaaat                                 96


<210>  227
<211>  723
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(723)
<223>  Cas6

<400>  227
atggatgtga aaatatatca gctgaaagta tttttaaagt taaatcaaaa tgtagatttt       60

ataaatagcc ctgagttttt aagcacaaat ttacataaag ctatgttggg ggatgaagct      120

ctacgatcta ttcatatgca aagatattta aagccttata gcatcggttt tttatacagt      180

atgaaaggca aaaaagatac ttttgtgagt ggtgaagata tgtattttta cgtaagaagt      240

attgatgaga gttttatatc taagttaaga atttgtttag aaaattctaa aaatcttggg      300

tttaatgtat atttatctaa atttgaaaat ttggatataa agcaagtcga tcgtttatat      360

actatgagtc cggcaactat cgtgcttaaa gaaggcgata aaactatacc ttggagacgt      420

gaaaatagcg atataacagt gcttaaagaa gctttgattt caaatttaaa aaacaaatac      480

gaatattttt tagacaaaaa aattgagata aaagatgata tcatcgaact tatagagata      540

aaaacaaata gagcgtttgc atttagatat aaaaacggta aaatttatgc ttatagatat      600

caaattcact tttcccaaaa cagattggct caagagtttg caaatatcgc catgatactt      660

ggtgttggag ttaaaaatac attgggattt ggcttttgta tgaggagtaa taatgctgtt      720

tga                                                                    723


<210>  228
<211>  1692
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(1692)
<223>  Cas8

<400>  228
atgctgtttg aattgcttga tgagtttaaa aaacagcttg aaaaaaataa gcacatagtc       60

acacaaaatc acattttaaa agacggagtt tatgcgagaa tttccgatga aaaatgtgag      120

attttttacg taaaaactat cacagaaaaa ataggtaaaa ctgcgcagaa aagaacgatt      180

ttatacaaac aaaacggaga tatcgcgtta aatgatgata tgcagtggtt tgagcaagct      240

gattatttaa gtttcttatg ggatatgaat aaagctgttt tgcctaataa aaaatttcac      300

agcattaact ttttgtctct attttttaag cttgaagagt ctgagtatgt taaggaaaat      360

ttggaagagt attttgatat ttttagagat tatagtgcat ttaataaagc aaaagataag      420

gaaattttat cattttatat ggattatata aaagatgaaa atagacaaaa cttgatcaca      480

aattcagtag ttttatctaa aaaatatttt aatgatataa atgattttgc tgtacaaaat      540

aactttaaaa agtgttatat taagtttttt attgacaaag attttgagat ttatgaaaaa      600

gagtcgcaaa tttatattga tttgaaaatt tacaattcaa atgaacacaa tataaaatat      660

aataatgaaa ttttcggtct ttcaaatttc aatatgggta tgaattcaaa aaaacctttt      720

ttagagcata aaaatagatt atttaaaata ccttacgcca taagtcaaaa agacgctctt      780

gctagtaaaa tgctttttga ttggcttggt tcgcaaaata aaagaattat tcgtgatttt      840

aactcaatct ttatatctaa attcaataaa caatcaaaag ccgtggtaag tgacttcgag      900

tatgttcctg tagataaaaa taagtttaaa tttgataaat ttaaacttaa aaattttatg      960

aatattgaaa atggtgaaaa agagatactt agttttgatg attttaagca agttattgat     1020

gagcagcttt atcataaatg tctttttggt aatttgtata atgatgagat aagagttagt     1080

aaaagaatca gcgaagatat gcaaaattta ctttatcaaa ctagatgttc tatggtggag     1140

tattttgata aatttaataa caatgaattt tactatgtta tacaaaaata ttctaatgat     1200

tttattaaaa ttgctatgca agatagtgaa tttggtagat taaacggtaa aaaatctata     1260

aatttgctac ttagtataaa agaaattaaa ggagaaaaag tggatataga cgggataaaa     1320

aatagagtta tatcagcact tactgatgat aatgtaacta aattaagcgg aaatgaatac     1380

tactttttag taggtaattt agcaatgtat ctagttagta aaagcaagac ttggaaaaag     1440

acgtttgcac taactgaccc atacactaaa gctagaaata caaaaaagct aaaaatggct     1500

ctgtttattg attttgatag atacaactat gatatttttt tagaaaatgg aatattaaaa     1560

aaagcatttt cattggctca aaattgtgaa gatatagtta tgtcaaataa cgaccaacag     1620

atggttttaa tcggtatgat gacaaaaaat ataattaaga aaccaggaga aaaagatgaa     1680

attagcgaat ag                                                         1692


<210>  229
<211>  942
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(942)
<223>  Cas7

<400>  229
atgaaattag cgaatagaat ttatggaata atcggtataa aatcaactat ggccaactgg       60

aatgcagatt ttagcggcag accaaaaagc acaggaaacg gagatatctt tgctagtgat      120

aaagctttaa aatatcctat gaaaaagatg tgggaaagct atggaaaaaa tattcttttt      180

gtaaaatctc taaaacaagg caagagtaag gatggcaatg acaagctcgt gccaaatact      240

ctaggagaaa gatatggttt gctttttggc gatatcaaaa aagcaaaatc cacaaaagag      300

gttttgagta acctttttaa ctgcattgat gttaaaaatt tcggtgctac attccctgaa      360

gatggttata acttatcaat aactggtgca gttcagatag gacaaggatt taataaattt      420

ggagatataa atatagaagt tcaaaatatc ttatctccat ttgccgattc aagagctaaa      480

gagaaaaacg aaaatggaga agatgcgagc caaagcactc tgggtacaaa aatagttaca      540

gatgaggctc attattttta cggattttgc ataaatccgt tagcttataa tgattataaa      600

gagattttgg gtgatgattt tggttacaat gaagatgatt acgctgagtt caaaaaggct      660

gctagatttt gcgctacgta ttttaattcc aactcaaaat tcggctgcga aaatgagttt      720

gctatgttca ttgaaacagc cgtagatgca tatctgcctg atcttagttc atatatggat      780

tttatttgca aagataaaaa tagattggta aatttagaaa aaatagaaaa aatgatagaa      840

agttcagatg taaaaaaagt agaaatttat tacaatcctt tatctttgga cgtagaaact      900

aaatttgata aattcgatat ttacagtgga aataaaatat ga                         942


<210>  230
<211>  762
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(762)
<223>  Cas5

<400>  230
atgaaagcca taagttttaa gcttagcgga aagtttgcac atttcaaaaa accagatgta       60

aatgaatatg tgtattttac ttataataat atcccaaaac caactctatt agggcttttg      120

ggggccatta tagggcttaa aggatacgcg caaaaaactt ataataataa aaaagataaa      180

aaatcacttt taaacaatga aaacagaagt aacgagccgg aattttatga gcgtttaaaa      240

catcttaaaa tttgtattat tcctcttgtt aaatatggta aattttctaa aaaaattcaa      300

gttttcaata attcagtagg atacgcaagc accgaagaag gtggaaattt aatagttaga      360

gagcaatggc ttgaaaatcc ttcttggcag atacttatag aagatgacgg aagtgcggag      420

tttgagacta tttcacaata tctatttgat aaaaaagcta agtttatacc atatcttggt      480

aaaaatgacc attttgcaga tataagcgaa gtggagaaaa tagatcttgc agagtctaaa      540

aaagataaaa ttgtgataaa atcgctgttt ttggataatt tagcaaagca ggttgatgac      600

cctgatgatg agatatcata tctttttaat gaattttatc ctattggttt taatgaactt      660

atgttttata agcttgaaaa aactactttt acaaatcaaa tttgtcaagc aatggacggg      720

aaatggtatg agtttaaaga cggaactata tgcttctttt aa                         762


<210>  231
<211>  723
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(723)
<223>  Cas6

<400>  231
atggatgtga agatctacca gctgaaggtg ttcctgaagc tgaatcagaa cgtggacttc       60

atcaacagcc cagagtttct gtccaccaat ctgcacaagg ccatgctggg cgatgaggcc      120

ctgaggtcca tccacatgca gcggtacctg aagccctact ctatcggctt tctgtacagc      180

atgaagggca agaaggacac atttgtgagc ggcgaggata tgtacttcta tgtgcggtcc      240

atcgacgagt ctttcatcag caagctgaga atctgcctgg agaattctaa gaacctgggc      300

tttaacgtgt atctgagcaa gttcgagaat ctggacatca agcaggtgga taggctgtac      360

accatgagcc ctgccacaat cgtgctgaag gagggcgata agaccatccc atggcggaga      420

gagaactccg acatcacagt gctgaaggag gccctgatct ctaatctgaa gaacaagtac      480

gagtatttcc tggacaagaa gatcgagatc aaggacgata tcatcgagct gatcgagatc      540

aagaccaatc gggccttcgc ctttagatat aagaacggca agatctacgc ctataggtac      600

cagatccact ttagccagaa ccgcctggcc caggagttcg ccaatatcgc catgatcctg      660

ggcgtgggcg tgaagaatac cctgggcttc ggcttttgca tgaggtccaa caatgcagtg      720

taa                                                                    723


<210>  232
<211>  1692
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(1692)
<223>  Cas8

<400>  232
atgctgttcg agctgctgga tgagtttaag aagcagctgg agaagaacaa gcacatcgtg       60

acacagaatc acatcctgaa ggatggcgtg tatgcccgca tctccgacga gaagtgtgag      120

atcttctacg tgaagaccat cacagagaag atcggcaaga ccgcccagaa gcggacaatc      180

ctgtataagc agaacggcga catcgccctg aatgacgata tgcagtggtt tgagcaggcc      240

gactacctga gcttcctgtg ggatatgaac aaggccgtgc tgcccaataa gaagttccac      300

agcatcaact ttctgtccct gttctttaag ctggaggagt ccgagtacgt gaaggagaat      360

ctggaggagt attttgacat cttcagagat tactccgcct ttaacaaggc caaggataag      420

gagatcctgt ctttctatat ggactacatc aaggatgaga ataggcagaa cctgatcacc      480

aattctgtgg tgctgagcaa gaagtacttc aatgacatca acgattttgc cgtgcagaac      540

aatttcaaga agtgctacat caagttcttt atcgacaagg atttcgagat ctacgagaag      600

gagagccaga tctatatcga cctgaagatc tacaattcca acgagcacaa catcaagtat      660

aacaatgaga tcttcggcct gtctaacttc aacatgggca tgaatagcaa gaagccattt      720

ctggagcaca agaaccgcct gttcaagatc ccctacgcca tctcccagaa ggatgccctg      780

gcctctaaga tgctgtttga ctggctgggc agccagaaca agcggatcat cagagacttt      840

aattccatct tcatctctaa gtttaacaag cagtctaagg ccgtggtgag cgacttcgag      900

tacgtgcccg tggataagaa caagtttaag ttcgacaagt tcaagctgaa gaacttcatg      960

aacatcgaga atggcgagaa ggagatcctg agctttgacg atttcaagca ggtcatcgat     1020

gagcagctgt atcacaagtg cctgtttggc aacctgtaca atgatgagat cagggtgagc     1080

aagcgcatct ccgaggacat gcagaatctg ctgtatcaga cccggtgttc catggtggag     1140

tactttgaca agttcaacaa taacgagttc tactatgtga tccagaagta ctctaacgac     1200

ttcatcaaga tcgccatgca ggacagcgag ttcggccgcc tgaacggcaa gaagagcatc     1260

aatctgctgc tgtccatcaa ggagatcaag ggcgagaagg tggacatcga tggcatcaag     1320

aatagagtga tctccgccct gaccgacgat aacgtgacaa agctgtctgg caatgagtac     1380

tattttctgg tgggcaacct ggccatgtac ctggtgagca agtccaagac ctggaagaag     1440

acattcgccc tgaccgatcc atatacaaag gcccggaaca ccaagaagct gaagatggcc     1500

ctgtttatcg acttcgatag atataactac gacatctttc tggagaatgg catcctgaag     1560

aaggccttca gcctggccca gaattgtgag gatatcgtga tgtccaataa cgaccagcag     1620

atggtgctga tcggcatgat gacaaagaac atcatcaaga agcccggcga gaaggacgag     1680

atcagcgagt aa                                                         1692


<210>  233
<211>  942
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(942)
<223>  Cas7

<400>  233
atgaagctgg ccaaccgcat ctacggcatc atcggcatca agagcaccat ggccaattgg       60

aacgccgact tttctggccg ccccaagagc acaggcaatg gcgacatctt cgccagcgat      120

aaggccctga agtatcctat gaagaagatg tgggagtcct acggcaagaa catcctgttc      180

gtgaagtccc tgaagcaggg caagtctaag gacggcaacg ataagctggt gccaaatacc      240

ctgggcgagc ggtatggcct gctgtttggc gatatcaaga aggccaagag cacaaaggag      300

gtgctgtcca atctgttcaa ctgcatcgat gtgaagaatt ttggcgccac cttcccagag      360

gacggctaca acctgagcat cacaggcgcc gtgcagatcg gccagggctt taacaagttc      420

ggcgacatca acatcgaggt gcagaatatc ctgtccccct tcgccgatag ccgggccaag      480

gagaagaatg agaacggaga ggacgcctcc cagtctaccc tgggcacaaa gatcgtgacc      540

gatgaggccc actactttta tggcttctgt atcaaccccc tggcctataa tgactacaag      600

gagatcctgg gcgacgattt tggctataat gaggacgatt acgccgagtt caagaaggcc      660

gccagattct gcgccaccta ctttaatagc aactccaagt ttggctgtga gaacgagttt      720

gccatgttca tcgagacagc cgtggacgcc tatctgcctg atctgagctc ctacatggac      780

ttcatctgca aggataagaa caggctggtg aatctggaga agatcgagaa gatgatcgag      840

tctagcgatg tgaagaaggt ggagatctac tataatcctc tgtccctgga cgtggagacc      900

aagtttgaca agttcgatat ctattctggc aacaagatct aa                         942


<210>  234
<211>  762
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(762)
<223>  Cas5

<400>  234
atgaaggcca tcagctttaa gctgtccggc aagtttgccc acttcaagaa gccagacgtg       60

aacgagtacg tgtacttcac ctacaacaat atccccaagc ctacactgct gggactgctg      120

ggagcaatca tcggcctgaa gggctatgcc cagaagacct acaacaataa gaaggacaag      180

aagagcctgc tgaacaatga gaatcggtcc aacgagcctg agttctatga gagactgaag      240

cacctgaaga tctgcatcat cccactggtg aagtacggca agttttctaa gaagatccag      300

gtgttcaaca attctgtggg atatgccagc accgaggagg gaggaaatct gatcgtgagg      360

gagcagtggc tggagaaccc cagctggcag atcctgatcg aggacgatgg ctctgccgag      420

tttgagacaa tcagccagta tctgttcgat aagaaggcca agtttatccc ttacctgggc      480

aagaatgacc acttcgccga tatctccgag gtggagaaga tcgacctggc cgagtccaag      540

aaggataaga tcgtgatcaa gtctctgttc ctggacaacc tggccaagca ggtggacgat      600

cccgacgatg agatctctta tctgtttaac gagttctacc ctatcggctt caatgagctg      660

atgttttaca agctggagaa gaccaccttc accaatcaga tctgtcaggc catggatggc      720

aagtggtatg agttcaagga cggcaccatc tgcttctttt aa                         762


<210>  235
<211>  240
<212>  PRT
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(240)
<223>  Cas6

<400>  235

Met Asp Val Lys Ile Tyr Gln Leu Lys Val Phe Leu Lys Leu Asn Gln 
1               5                   10                  15      


Asn Val Asp Phe Ile Asn Ser Pro Glu Phe Leu Ser Thr Asn Leu His 
            20                  25                  30          


Lys Ala Met Leu Gly Asp Glu Ala Leu Arg Ser Ile His Met Gln Arg 
        35                  40                  45              


Tyr Leu Lys Pro Tyr Ser Ile Gly Phe Leu Tyr Ser Met Lys Gly Lys 
    50                  55                  60                  


Lys Asp Thr Phe Val Ser Gly Glu Asp Met Tyr Phe Tyr Val Arg Ser 
65                  70                  75                  80  


Ile Asp Glu Ser Phe Ile Ser Lys Leu Arg Ile Cys Leu Glu Asn Ser 
                85                  90                  95      


Lys Asn Leu Gly Phe Asn Val Tyr Leu Ser Lys Phe Glu Asn Leu Asp 
            100                 105                 110         


Ile Lys Gln Val Asp Arg Leu Tyr Thr Met Ser Pro Ala Thr Ile Val 
        115                 120                 125             


Leu Lys Glu Gly Asp Lys Thr Ile Pro Trp Arg Arg Glu Asn Ser Asp 
    130                 135                 140                 


Ile Thr Val Leu Lys Glu Ala Leu Ile Ser Asn Leu Lys Asn Lys Tyr 
145                 150                 155                 160 


Glu Tyr Phe Leu Asp Lys Lys Ile Glu Ile Lys Asp Asp Ile Ile Glu 
                165                 170                 175     


Leu Ile Glu Ile Lys Thr Asn Arg Ala Phe Ala Phe Arg Tyr Lys Asn 
            180                 185                 190         


Gly Lys Ile Tyr Ala Tyr Arg Tyr Gln Ile His Phe Ser Gln Asn Arg 
        195                 200                 205             


Leu Ala Gln Glu Phe Ala Asn Ile Ala Met Ile Leu Gly Val Gly Val 
    210                 215                 220                 


Lys Asn Thr Leu Gly Phe Gly Phe Cys Met Arg Ser Asn Asn Ala Val 
225                 230                 235                 240 


<210>  236
<211>  563
<212>  PRT
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(563)
<223>  Cas8

<400>  236

Met Leu Phe Glu Leu Leu Asp Glu Phe Lys Lys Gln Leu Glu Lys Asn 
1               5                   10                  15      


Lys His Ile Val Thr Gln Asn His Ile Leu Lys Asp Gly Val Tyr Ala 
            20                  25                  30          


Arg Ile Ser Asp Glu Lys Cys Glu Ile Phe Tyr Val Lys Thr Ile Thr 
        35                  40                  45              


Glu Lys Ile Gly Lys Thr Ala Gln Lys Arg Thr Ile Leu Tyr Lys Gln 
    50                  55                  60                  


Asn Gly Asp Ile Ala Leu Asn Asp Asp Met Gln Trp Phe Glu Gln Ala 
65                  70                  75                  80  


Asp Tyr Leu Ser Phe Leu Trp Asp Met Asn Lys Ala Val Leu Pro Asn 
                85                  90                  95      


Lys Lys Phe His Ser Ile Asn Phe Leu Ser Leu Phe Phe Lys Leu Glu 
            100                 105                 110         


Glu Ser Glu Tyr Val Lys Glu Asn Leu Glu Glu Tyr Phe Asp Ile Phe 
        115                 120                 125             


Arg Asp Tyr Ser Ala Phe Asn Lys Ala Lys Asp Lys Glu Ile Leu Ser 
    130                 135                 140                 


Phe Tyr Met Asp Tyr Ile Lys Asp Glu Asn Arg Gln Asn Leu Ile Thr 
145                 150                 155                 160 


Asn Ser Val Val Leu Ser Lys Lys Tyr Phe Asn Asp Ile Asn Asp Phe 
                165                 170                 175     


Ala Val Gln Asn Asn Phe Lys Lys Cys Tyr Ile Lys Phe Phe Ile Asp 
            180                 185                 190         


Lys Asp Phe Glu Ile Tyr Glu Lys Glu Ser Gln Ile Tyr Ile Asp Leu 
        195                 200                 205             


Lys Ile Tyr Asn Ser Asn Glu His Asn Ile Lys Tyr Asn Asn Glu Ile 
    210                 215                 220                 


Phe Gly Leu Ser Asn Phe Asn Met Gly Met Asn Ser Lys Lys Pro Phe 
225                 230                 235                 240 


Leu Glu His Lys Asn Arg Leu Phe Lys Ile Pro Tyr Ala Ile Ser Gln 
                245                 250                 255     


Lys Asp Ala Leu Ala Ser Lys Met Leu Phe Asp Trp Leu Gly Ser Gln 
            260                 265                 270         


Asn Lys Arg Ile Ile Arg Asp Phe Asn Ser Ile Phe Ile Ser Lys Phe 
        275                 280                 285             


Asn Lys Gln Ser Lys Ala Val Val Ser Asp Phe Glu Tyr Val Pro Val 
    290                 295                 300                 


Asp Lys Asn Lys Phe Lys Phe Asp Lys Phe Lys Leu Lys Asn Phe Met 
305                 310                 315                 320 


Asn Ile Glu Asn Gly Glu Lys Glu Ile Leu Ser Phe Asp Asp Phe Lys 
                325                 330                 335     


Gln Val Ile Asp Glu Gln Leu Tyr His Lys Cys Leu Phe Gly Asn Leu 
            340                 345                 350         


Tyr Asn Asp Glu Ile Arg Val Ser Lys Arg Ile Ser Glu Asp Met Gln 
        355                 360                 365             


Asn Leu Leu Tyr Gln Thr Arg Cys Ser Met Val Glu Tyr Phe Asp Lys 
    370                 375                 380                 


Phe Asn Asn Asn Glu Phe Tyr Tyr Val Ile Gln Lys Tyr Ser Asn Asp 
385                 390                 395                 400 


Phe Ile Lys Ile Ala Met Gln Asp Ser Glu Phe Gly Arg Leu Asn Gly 
                405                 410                 415     


Lys Lys Ser Ile Asn Leu Leu Leu Ser Ile Lys Glu Ile Lys Gly Glu 
            420                 425                 430         


Lys Val Asp Ile Asp Gly Ile Lys Asn Arg Val Ile Ser Ala Leu Thr 
        435                 440                 445             


Asp Asp Asn Val Thr Lys Leu Ser Gly Asn Glu Tyr Tyr Phe Leu Val 
    450                 455                 460                 


Gly Asn Leu Ala Met Tyr Leu Val Ser Lys Ser Lys Thr Trp Lys Lys 
465                 470                 475                 480 


Thr Phe Ala Leu Thr Asp Pro Tyr Thr Lys Ala Arg Asn Thr Lys Lys 
                485                 490                 495     


Leu Lys Met Ala Leu Phe Ile Asp Phe Asp Arg Tyr Asn Tyr Asp Ile 
            500                 505                 510         


Phe Leu Glu Asn Gly Ile Leu Lys Lys Ala Phe Ser Leu Ala Gln Asn 
        515                 520                 525             


Cys Glu Asp Ile Val Met Ser Asn Asn Asp Gln Gln Met Val Leu Ile 
    530                 535                 540                 


Gly Met Met Thr Lys Asn Ile Ile Lys Lys Pro Gly Glu Lys Asp Glu 
545                 550                 555                 560 


Ile Ser Glu 
            


<210>  237
<211>  313
<212>  PRT
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(313)
<223>  Cas7

<400>  237

Met Lys Leu Ala Asn Arg Ile Tyr Gly Ile Ile Gly Ile Lys Ser Thr 
1               5                   10                  15      


Met Ala Asn Trp Asn Ala Asp Phe Ser Gly Arg Pro Lys Ser Thr Gly 
            20                  25                  30          


Asn Gly Asp Ile Phe Ala Ser Asp Lys Ala Leu Lys Tyr Pro Met Lys 
        35                  40                  45              


Lys Met Trp Glu Ser Tyr Gly Lys Asn Ile Leu Phe Val Lys Ser Leu 
    50                  55                  60                  


Lys Gln Gly Lys Ser Lys Asp Gly Asn Asp Lys Leu Val Pro Asn Thr 
65                  70                  75                  80  


Leu Gly Glu Arg Tyr Gly Leu Leu Phe Gly Asp Ile Lys Lys Ala Lys 
                85                  90                  95      


Ser Thr Lys Glu Val Leu Ser Asn Leu Phe Asn Cys Ile Asp Val Lys 
            100                 105                 110         


Asn Phe Gly Ala Thr Phe Pro Glu Asp Gly Tyr Asn Leu Ser Ile Thr 
        115                 120                 125             


Gly Ala Val Gln Ile Gly Gln Gly Phe Asn Lys Phe Gly Asp Ile Asn 
    130                 135                 140                 


Ile Glu Val Gln Asn Ile Leu Ser Pro Phe Ala Asp Ser Arg Ala Lys 
145                 150                 155                 160 


Glu Lys Asn Glu Asn Gly Glu Asp Ala Ser Gln Ser Thr Leu Gly Thr 
                165                 170                 175     


Lys Ile Val Thr Asp Glu Ala His Tyr Phe Tyr Gly Phe Cys Ile Asn 
            180                 185                 190         


Pro Leu Ala Tyr Asn Asp Tyr Lys Glu Ile Leu Gly Asp Asp Phe Gly 
        195                 200                 205             


Tyr Asn Glu Asp Asp Tyr Ala Glu Phe Lys Lys Ala Ala Arg Phe Cys 
    210                 215                 220                 


Ala Thr Tyr Phe Asn Ser Asn Ser Lys Phe Gly Cys Glu Asn Glu Phe 
225                 230                 235                 240 


Ala Met Phe Ile Glu Thr Ala Val Asp Ala Tyr Leu Pro Asp Leu Ser 
                245                 250                 255     


Ser Tyr Met Asp Phe Ile Cys Lys Asp Lys Asn Arg Leu Val Asn Leu 
            260                 265                 270         


Glu Lys Ile Glu Lys Met Ile Glu Ser Ser Asp Val Lys Lys Val Glu 
        275                 280                 285             


Ile Tyr Tyr Asn Pro Leu Ser Leu Asp Val Glu Thr Lys Phe Asp Lys 
    290                 295                 300                 


Phe Asp Ile Tyr Ser Gly Asn Lys Ile 
305                 310             


<210>  238
<211>  253
<212>  PRT
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(253)
<223>  Cas5

<400>  238

Met Lys Ala Ile Ser Phe Lys Leu Ser Gly Lys Phe Ala His Phe Lys 
1               5                   10                  15      


Lys Pro Asp Val Asn Glu Tyr Val Tyr Phe Thr Tyr Asn Asn Ile Pro 
            20                  25                  30          


Lys Pro Thr Leu Leu Gly Leu Leu Gly Ala Ile Ile Gly Leu Lys Gly 
        35                  40                  45              


Tyr Ala Gln Lys Thr Tyr Asn Asn Lys Lys Asp Lys Lys Ser Leu Leu 
    50                  55                  60                  


Asn Asn Glu Asn Arg Ser Asn Glu Pro Glu Phe Tyr Glu Arg Leu Lys 
65                  70                  75                  80  


His Leu Lys Ile Cys Ile Ile Pro Leu Val Lys Tyr Gly Lys Phe Ser 
                85                  90                  95      


Lys Lys Ile Gln Val Phe Asn Asn Ser Val Gly Tyr Ala Ser Thr Glu 
            100                 105                 110         


Glu Gly Gly Asn Leu Ile Val Arg Glu Gln Trp Leu Glu Asn Pro Ser 
        115                 120                 125             


Trp Gln Ile Leu Ile Glu Asp Asp Gly Ser Ala Glu Phe Glu Thr Ile 
    130                 135                 140                 


Ser Gln Tyr Leu Phe Asp Lys Lys Ala Lys Phe Ile Pro Tyr Leu Gly 
145                 150                 155                 160 


Lys Asn Asp His Phe Ala Asp Ile Ser Glu Val Glu Lys Ile Asp Leu 
                165                 170                 175     


Ala Glu Ser Lys Lys Asp Lys Ile Val Ile Lys Ser Leu Phe Leu Asp 
            180                 185                 190         


Asn Leu Ala Lys Gln Val Asp Asp Pro Asp Asp Glu Ile Ser Tyr Leu 
        195                 200                 205             


Phe Asn Glu Phe Tyr Pro Ile Gly Phe Asn Glu Leu Met Phe Tyr Lys 
    210                 215                 220                 


Leu Glu Lys Thr Thr Phe Thr Asn Gln Ile Cys Gln Ala Met Asp Gly 
225                 230                 235                 240 


Lys Trp Tyr Glu Phe Lys Asp Gly Thr Ile Cys Phe Phe 
                245                 250             


<210>  239
<211>  95
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3


<220>
<221>  misc_feature
<222>  (1)..(95)
<223>  CRISPR

<400>  239
gtttgctaat gacaatattt gtgttaaaac aagcgtagca ccaaaagaag cgtatgaaag       60

cataggtttg ctaatgacaa tatttgtgtt aaaac                                  95


<210>  240
<211>  771
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(771)
<223>  Cas6

<400>  240
atgcgtttga aattggtact taaaattgtg gaaggaaccg ttttaccttg taattatatg       60

tatgaattgt caagttgttt gtacaaggta ttgaatgaag gtaatccggt ttttactgcc      120

tggctacatg ataaaggata ttgtaaggaa aagaaagcat ttaaattatt taccttttcg      180

aatttctatt ttccgtgttt cagaatcgag ggggatcgga tttttgtttt ggcggatacg      240

gcccagttga ttgtgtcgtt ctatccgata gaagcaattg atgcttttgt aatgggtctg      300

tttaagaaca ggcaattgga ggttggtgac cggaaatcga gggtccgctt tgaagtcttt      360

aacttagagc ggcaggctga gccggaattc acttcccgga tgttttttaa aactctatcg      420

cctatgttta ttgaagagca attaccggaa acccggaaag cgatacatct ttcaccgggg      480

aatccgaagt ttgcagaatt gttgcatttg aatctgctgg ataaatacag ggtgttttat      540

ggacaggaac ccgatccgtc ctggcctctg acccgcttgc atttgttgtc tgagcccaag      600

cctaaaacaa ttgtgctgaa ggtaggtact ccggaggaaa ccagaatgaa aggatatact      660

ttccgctttg agctggaagg acagccggaa ttattgcgtc tgggttacga aggtggtttc      720

ggacgattga acagccaggg attcggttgt gtggaagtgt tgaaacagtg a               771


<210>  241
<211>  1845
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(1845)
<223>  Cas8

<400>  241
atgcttcagg aaattaataa ctttatgaat agtttgcctg ctgagttaaa gcaggcgggg       60

ctgaagccta aagaaggact gcatgttttg ctgaaaatcc aggaaaagga gggaactcat      120

tttatggacg aacagtctgt ctgccgggtt tgtctgaccc ggaaagcgac agaattcgat      180

tatccttttt tacagcattg tgctgagctg gctcaggtgg gatggtgtgt gaataccaat      240

aaatgtttcg atcttccggc taaggggctg cattcctgtt ctccttattg cattgccttg      300

aaacgggaat ctctggaagg aggaggaaaa tatgcgaaag ataagactaa aatctacgac      360

cgtatcgata cttattttgc taatgcttta tcctacgtcg aagaggatag cgagaaagaa      420

agaataaggg tttttcagca ttttatcaac tccaaagaga aactgaatgc tttatttgcc      480

tgttttcagt cagaggttga tgaagtcaag gataaggagt acattattct ttatttggag      540

gaggagatgg aaaaatatcg ccgggttcat gaaaaatatt tgtcggacaa attattcaat      600

accaatgaat acaatatttc ggtagaaaat caactctatg ggaccagcga tttcctgaat      660

ggatttccaa ctaaaaagcc ttttttatcc catcagtcgg ctgttttcga tattgccggg      720

cggattaccg gagagatggc tggaaatctc catgattttc aggaaatcat gcgccggaat      780

gttttacccc gtcctttgcc gttgtttgtt taccgggaag agttgcagac cgaaatgctt      840

gcggttttct cccggtattt ggcggatggc aagaggatcg gttatcagga gatcatacgg      900

gagctttata aaaatcatca ggacgatatc ggtgattatt atttattgta ttactatggc      960

gatacggttt gtgatttcga ttttgtttcc cgtttccgct atcgtttgca gagtggggat     1020

aaagaaggtt ggatggtaaa agatcatttt cagatcggtt ttacggagaa aataagccat     1080

gtatttgagt tggaggaaaa agtgttacgc gaaatattta ataactcgtt gattacacga     1140

acgaaagccg gagatacaca acgtaaatat ttcgatgaat tagaaccgaa atactgtaaa     1200

tcggaaaata actatttatt ggtattgaag tatcggcaag ctttttatga ttatatctat     1260

aaatccagat tacaggctgt tacccgtcct atgttcgatc atattttatt gaccggtatt     1320

ttggaggata tccgtttgga tgaattaaaa ggaaaccagc atacccaacg ctgggggatt     1380

ttgtctaaaa tgaacatttg gttcagtttg gctgaacgtt ttgatttaca atttaaaaat     1440

acagatacta tggcaagtaa attggaagaa cagagagtgt ttatggttgc cttatcgcaa     1500

ggtgaggcta tattggaaaa cgacgaacaa tatgcttttg cagccggaca ggtgatttac     1560

tatttattac ataagagtaa gacggcagac aaaagttata aacggctgga gccttttttg     1620

cagcaggtgc acgcctctga attgaataaa gcgattgccc ggcttttcga tacctataag     1680

catgagaatt tttcaggcaa tttccgtcat ccgtttgcat cggttatggc ctatcagacc     1740

caagcgaata tgcgggacta cctgcccatg atgctggccg ggattttttc ggataatctg     1800

ctttttagcg ttaataaatc agaagaaaca aatgaagaaa actaa                     1845


<210>  242
<211>  939
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(939)
<223>  Cas7

<400>  242
atgagtaata catttaaaaa cagagtgttt ggttgtgtgg taatcaaatc tgtcaattcc       60

aattataatg cggacttttc acatcagccc cgtactttgc ccgatgggtc ggtatatgca      120

acagataaag cattgaaata taccgttcgg aattatatag ataaaaatta tccggaagac      180

aaggtatttt attttaaaag cctgaatgga gatatgcagc cccgggattt agaccagaat      240

tatgcccgtt tcttcggcga ttatccgaaa gcggataaga aagaggcggt caaggcgcgt      300

aaagtgattc tgggaaattt gttgagctgt ctggatgtac ggttatttgg cggaactttt      360

gccagtaaaa cggccaattt gtctattcat ggtgttgtac aaccgacgca tggggtgaac      420

cgatatgtgg aagggattat ctattcagag cagattgctt cgcctttccg gaactccaat      480

gataatagta cggattcgat gcaaacgact ttaggaaccc aatttaaatt acaggaaggc      540

cattacgtac atcatttttc agtcaatccc ggtaatttag acgaactgac tgaatttgtc      600

gataatggaa gattaacggg ggaggatatt gccaaattga aagaagcttt acgttgcgga      660

gtgacatatt atgattcctc ttccaaggca ggaacggaga atgaggcctt gttgtgggtg      720

gaattgaaag aagagtcgaa gctggtatta ccctctttcg tggatttgat agaggtaaat      780

gcagaacggg aaattgattt tgcgaaagtg agtaccttat tgtccaaaga aaaaatcaaa      840

aatgagatct caaaaattga attgttttac aataagggaa ttacaaaagt gattcatctg      900

ccggaaggaa cggtcgaact tgaattgaac gggttatga                             939


<210>  243
<211>  780
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(780)
<223>  Cas5

<400>  243
atgaataatc aacgactgat ttcatttgat atacaggctg atttcggttt cttcaaaaag       60

cccgattaca atgatggggt gttgctgacc tataatatgt tacataagcc cgccctgtta      120

ggcatattgg gggctattat cggtttgcgg ggttatcgga aaaaaggaga atggccggaa      180

tattaccagc ggttggctgc cctcccggtg ggaatagaac ctttggaggg gagacatgag      240

aaagggaatt ttcagaaaac gatagtcaag tatacgaata cggtcggata tgctaatcag      300

gatggtaacc tgctggttga agagagtatg ctgattcgtc cggcctatcg ctgctatctt      360

ttgttgtcgg aagagcatcc ggatcaccgg aagttgtacg agtatatccg ggaaggatgg      420

gccgagtata ttccctattt gggtaaaaat gaatatccgg cctggttcgg agattcgttc      480

cgggaatatg cttttaaaac ttttgtaccg gaaactgatt tccgggtttc atccttgttt      540

atcaaagaag gagtattgaa aggacagcag gtaaaggcca gtttttcgtt ttcgctgaaa      600

ggcatagtga atcgaggtag ttttgtgtat ttcgaacgtt tgcctgttgg ttttcatccg      660

gttctgatgc aatatgaatt ggccgacttc gcttttacgg attggacctt acaggctgcc      720

acgcagatgg taaatttgta tcagctggaa gaggaaggaa agattgttca attgttttga      780


<210>  244
<211>  771
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(771)
<223>  Cas6

<400>  244
atgaggctga agctggtgct gaagatcgtg gagggcacag tgctgccctg caactatatg       60

tacgagctga gctcctgtct gtacaaggtg ctgaacgagg gcaatcccgt gttcaccgcc      120

tggctgcacg ataagggcta ttgcaaggag aagaaggcct ttaagctgtt cacattttcc      180

aatttctact ttccatgttt cagaatcgag ggcgacagga tctttgtgct ggccgatacc      240

gcccagctga tcgtgtcttt ctaccccatc gaggccatcg acgccttcgt gatgggcctg      300

tttaagaacc gccagctgga agtgggcgat cggaagtcca gggtgcgctt tgaggtgttc      360

aatctggaga ggcaggcaga gcctgagttc accagccgga tgttctttaa gacactgtcc      420

ccaatgttta tcgaggagca gctgcccgag acaagaaagg ccatccacct gtctcctggc      480

aacccaaagt tcgccgagct gctgcacctg aatctgctgg acaagtacag agtgttttat      540

ggccaggagc ccgatcctag ctggccactg accaggctgc acctgctgtc cgagccaaag      600

cccaagacaa tcgtgctgaa ggtcggcacc cccgaggaga caagaatgaa gggctatacc      660

ttcaggtttg agctggaggg ccagcctgag ctgctgagac tgggatacga gggaggattc      720

ggcaggctga acagccaggg ctttggctgc gtggaggtgc tgaagcagta a               771


<210>  245
<211>  1845
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(1845)
<223>  Cas8

<400>  245
atgctgcagg agatcaacaa tttcatgaat tctctgccag cagagctgaa gcaggcaggc       60

ctgaagccaa aggagggact gcacgtgctg ctgaagatcc aggagaagga gggcacccac      120

tttatggacg agcagtccgt gtgccgggtg tgcctgaccc ggaaggcaac agagtttgat      180

taccccttcc tgcagcactg cgcagagctg gcccaagtgg gatggtgcgt gaacacaaat      240

aagtgtttcg acctgcctgc caagggcctg cactcttgca gcccatattg tatcgccctg      300

aagagagaga gcctggaggg aggcggcaag tacgcaaagg acaagaccaa gatctatgac      360

aggatcgata catactttgc caacgccctg agctacgtgg aggaggattc cgagaaggag      420

cggatcagag tgtttcagca cttcatcaac tccaaggaga agctgaatgc cctgtttgcc      480

tgtttccagt ctgaggtgga cgaggtgaag gataaggagt acatcatcct gtatctggag      540

gaggagatgg agaagtatag gcgcgtgcac gagaagtacc tgtccgacaa gctgttcaac      600

accaatgagt ataacatcag cgtggagaat cagctgtacg gcacctccga ttttctgaac      660

ggcttcccaa caaagaagcc cttcctgagc caccagtccg ccgtgtttga catcgcagga      720

aggatcaccg gagagatggc aggcaacctg cacgattttc aggagatcat gcggagaaat      780

gtgctgcctc gcccactgcc cctgttcgtg tatcgggagg agctgcagac agagatgctg      840

gccgtgttta gcagatacct ggccgacggc aagaggatcg gctatcagga gatcatccgc      900

gagctgtaca agaaccacca ggacgatatc ggcgactact atctgctgta ctattacggc      960

gataccgtgt gcgactttga tttcgtgtct aggttccgct acaggctgca gagcggcgac     1020

aaggagggat ggatggtgaa ggatcacttt cagatcggct tcaccgagaa gatcagccac     1080

gtgttcgagc tggaggagaa ggtgctgcgg gagatcttta acaattccct gatcaccaga     1140

acaaaggccg gcgacacaca gaggaagtat ttcgatgagc tggagcccaa gtactgtaag     1200

tctgagaaca attatctgct ggtgctgaag tacagacagg ccttctatga ctacatctat     1260

aagagccgcc tgcaggcagt gacccggcct atgtttgatc acatcctgct gacaggcatc     1320

ctggaggaca tcagactgga tgagctgaag ggcaaccagc acacccagag gtggggcatc     1380

ctgtccaaga tgaatatctg gttctctctg gccgagcggt tcgacctgca gttcaagaac     1440

accgatacaa tggccagcaa gctggaggag cagcgggtgt tcatggtggc cctgtcccag     1500

ggagaggcaa tcctggagaa tgacgagcag tacgcctttg ccgccggcca ggtcatctac     1560

tacctgctgc acaagtctaa gaccgccgat aagagctata agaggctgga gcccttcctg     1620

cagcaggtgc acgcctccga gctgaacaag gccatcgccc gcctgtttga cacctacaag     1680

cacgagaact tttctggcaa tttccggcac ccatttgcca gcgtgatggc ctatcagaca     1740

caggccaata tgcgcgacta cctgcccatg atgctggccg gcatcttcag cgataacctg     1800

ctgttttccg tgaataagtc tgaggagacc aacgaggaga attaa                     1845


<210>  246
<211>  939
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(939)
<223>  Cas7

<400>  246
atgtctaaca ccttcaagaa tcgggtgttt ggctgcgtgg tcatcaagag cgtgaactcc       60

aattataacg ccgacttctc ccaccagcca cgcacactgc ctgacggcag cgtgtacgcc      120

accgataagg ccctgaagta cacagtgcgg aactatatcg acaagaatta ccctgaggat      180

aaggtgttct actttaagtc tctgaacggc gacatgcagc cacgcgacct ggatcagaat      240

tatgcccggt tctttggcga ctaccccaag gccgataaga aggaggccgt gaaggccaga      300

aaagtgatcc tgggcaacct gctgagctgt ctggatgtga ggctgtttgg cggcaccttc      360

gcctctaaga cagccaacct gagcatccac ggagtggtgc agcctaccca cggagtgaat      420

agatatgtgg agggcatcat ctacagcgag cagatcgcct ccccattcag gaattctaac      480

gacaattcta ccgatagcat gcagaccaca ctgggcacac agttcaagct gcaggagggc      540

cactacgtgc accactttag cgtgaaccca ggcaatctgg acgagctgac cgagtttgtg      600

gataacggcc gcctgacagg cgaggacatc gcaaagctga aggaggccct gagatgcgga      660

gtgacctact atgatagctc ctctaaggcc ggcacagaga acgaggccct gctgtgggtg      720

gagctgaagg aggagtccaa gctggtgctg ccctctttcg tggacctgat cgaagtgaat      780

gccgagcggg agatcgattt tgccaaggtg tctaccctgc tgagcaagga gaagatcaag      840

aacgagatct ccaagatcga gctgttctac aataagggca tcaccaaagt gatccacctg      900

cctgagggca cagtggagct ggagctgaac ggactgtaa                             939


<210>  247
<211>  780
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(780)
<223>  Cas5

<400>  247
atgaacaatc agcggctgat ctctttcgac atccaggccg attttggctt ctttaagaag       60

cctgactata acgatggcgt gctgctgacc tacaatatgc tgcacaagcc agccctgctg      120

ggcatcctgg gagccatcat cggcctgaga ggctacagga agaagggcga gtggcccgag      180

tactatcaga gactggccgc cctgcctgtg ggaatcgagc cactggaggg caggcacgag      240

aagggcaact tccagaagac aatcgtgaag tataccaata cagtgggcta cgccaaccag      300

gacggcaatc tgctggtgga ggagtctatg ctgatccgcc ctgcctaccg gtgctatctg      360

ctgctgagcg aggagcaccc agatcaccgc aagctgtatg agtacatccg ggagggctgg      420

gccgagtaca tcccttatct gggcaagaac gagtatccag cctggtttgg cgactccttc      480

cgcgagtacg cctttaagac cttcgtgcct gagacagatt tccgggtgtc tagcctgttt      540

atcaaggagg gcgtgctgaa gggccagcag gtgaaggcct ccttctcttt tagcctgaag      600

ggcatcgtga atagaggcag cttcgtgtac ttcgagaggc tgcccgtggg cttccaccct      660

gtgctgatgc agtacgagct ggccgacttc gcctttaccg attggacact gcaggccgcc      720

acccagatgg tgaacctgta ccagctggag gaggagggca agatcgtgca gctgttttaa      780


<210>  248
<211>  256
<212>  PRT
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(256)
<223>  Cas6

<400>  248

Met Arg Leu Lys Leu Val Leu Lys Ile Val Glu Gly Thr Val Leu Pro 
1               5                   10                  15      


Cys Asn Tyr Met Tyr Glu Leu Ser Ser Cys Leu Tyr Lys Val Leu Asn 
            20                  25                  30          


Glu Gly Asn Pro Val Phe Thr Ala Trp Leu His Asp Lys Gly Tyr Cys 
        35                  40                  45              


Lys Glu Lys Lys Ala Phe Lys Leu Phe Thr Phe Ser Asn Phe Tyr Phe 
    50                  55                  60                  


Pro Cys Phe Arg Ile Glu Gly Asp Arg Ile Phe Val Leu Ala Asp Thr 
65                  70                  75                  80  


Ala Gln Leu Ile Val Ser Phe Tyr Pro Ile Glu Ala Ile Asp Ala Phe 
                85                  90                  95      


Val Met Gly Leu Phe Lys Asn Arg Gln Leu Glu Val Gly Asp Arg Lys 
            100                 105                 110         


Ser Arg Val Arg Phe Glu Val Phe Asn Leu Glu Arg Gln Ala Glu Pro 
        115                 120                 125             


Glu Phe Thr Ser Arg Met Phe Phe Lys Thr Leu Ser Pro Met Phe Ile 
    130                 135                 140                 


Glu Glu Gln Leu Pro Glu Thr Arg Lys Ala Ile His Leu Ser Pro Gly 
145                 150                 155                 160 


Asn Pro Lys Phe Ala Glu Leu Leu His Leu Asn Leu Leu Asp Lys Tyr 
                165                 170                 175     


Arg Val Phe Tyr Gly Gln Glu Pro Asp Pro Ser Trp Pro Leu Thr Arg 
            180                 185                 190         


Leu His Leu Leu Ser Glu Pro Lys Pro Lys Thr Ile Val Leu Lys Val 
        195                 200                 205             


Gly Thr Pro Glu Glu Thr Arg Met Lys Gly Tyr Thr Phe Arg Phe Glu 
    210                 215                 220                 


Leu Glu Gly Gln Pro Glu Leu Leu Arg Leu Gly Tyr Glu Gly Gly Phe 
225                 230                 235                 240 


Gly Arg Leu Asn Ser Gln Gly Phe Gly Cys Val Glu Val Leu Lys Gln 
                245                 250                 255     


<210>  249
<211>  614
<212>  PRT
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(614)
<223>  Cas8

<400>  249

Met Leu Gln Glu Ile Asn Asn Phe Met Asn Ser Leu Pro Ala Glu Leu 
1               5                   10                  15      


Lys Gln Ala Gly Leu Lys Pro Lys Glu Gly Leu His Val Leu Leu Lys 
            20                  25                  30          


Ile Gln Glu Lys Glu Gly Thr His Phe Met Asp Glu Gln Ser Val Cys 
        35                  40                  45              


Arg Val Cys Leu Thr Arg Lys Ala Thr Glu Phe Asp Tyr Pro Phe Leu 
    50                  55                  60                  


Gln His Cys Ala Glu Leu Ala Gln Val Gly Trp Cys Val Asn Thr Asn 
65                  70                  75                  80  


Lys Cys Phe Asp Leu Pro Ala Lys Gly Leu His Ser Cys Ser Pro Tyr 
                85                  90                  95      


Cys Ile Ala Leu Lys Arg Glu Ser Leu Glu Gly Gly Gly Lys Tyr Ala 
            100                 105                 110         


Lys Asp Lys Thr Lys Ile Tyr Asp Arg Ile Asp Thr Tyr Phe Ala Asn 
        115                 120                 125             


Ala Leu Ser Tyr Val Glu Glu Asp Ser Glu Lys Glu Arg Ile Arg Val 
    130                 135                 140                 


Phe Gln His Phe Ile Asn Ser Lys Glu Lys Leu Asn Ala Leu Phe Ala 
145                 150                 155                 160 


Cys Phe Gln Ser Glu Val Asp Glu Val Lys Asp Lys Glu Tyr Ile Ile 
                165                 170                 175     


Leu Tyr Leu Glu Glu Glu Met Glu Lys Tyr Arg Arg Val His Glu Lys 
            180                 185                 190         


Tyr Leu Ser Asp Lys Leu Phe Asn Thr Asn Glu Tyr Asn Ile Ser Val 
        195                 200                 205             


Glu Asn Gln Leu Tyr Gly Thr Ser Asp Phe Leu Asn Gly Phe Pro Thr 
    210                 215                 220                 


Lys Lys Pro Phe Leu Ser His Gln Ser Ala Val Phe Asp Ile Ala Gly 
225                 230                 235                 240 


Arg Ile Thr Gly Glu Met Ala Gly Asn Leu His Asp Phe Gln Glu Ile 
                245                 250                 255     


Met Arg Arg Asn Val Leu Pro Arg Pro Leu Pro Leu Phe Val Tyr Arg 
            260                 265                 270         


Glu Glu Leu Gln Thr Glu Met Leu Ala Val Phe Ser Arg Tyr Leu Ala 
        275                 280                 285             


Asp Gly Lys Arg Ile Gly Tyr Gln Glu Ile Ile Arg Glu Leu Tyr Lys 
    290                 295                 300                 


Asn His Gln Asp Asp Ile Gly Asp Tyr Tyr Leu Leu Tyr Tyr Tyr Gly 
305                 310                 315                 320 


Asp Thr Val Cys Asp Phe Asp Phe Val Ser Arg Phe Arg Tyr Arg Leu 
                325                 330                 335     


Gln Ser Gly Asp Lys Glu Gly Trp Met Val Lys Asp His Phe Gln Ile 
            340                 345                 350         


Gly Phe Thr Glu Lys Ile Ser His Val Phe Glu Leu Glu Glu Lys Val 
        355                 360                 365             


Leu Arg Glu Ile Phe Asn Asn Ser Leu Ile Thr Arg Thr Lys Ala Gly 
    370                 375                 380                 


Asp Thr Gln Arg Lys Tyr Phe Asp Glu Leu Glu Pro Lys Tyr Cys Lys 
385                 390                 395                 400 


Ser Glu Asn Asn Tyr Leu Leu Val Leu Lys Tyr Arg Gln Ala Phe Tyr 
                405                 410                 415     


Asp Tyr Ile Tyr Lys Ser Arg Leu Gln Ala Val Thr Arg Pro Met Phe 
            420                 425                 430         


Asp His Ile Leu Leu Thr Gly Ile Leu Glu Asp Ile Arg Leu Asp Glu 
        435                 440                 445             


Leu Lys Gly Asn Gln His Thr Gln Arg Trp Gly Ile Leu Ser Lys Met 
    450                 455                 460                 


Asn Ile Trp Phe Ser Leu Ala Glu Arg Phe Asp Leu Gln Phe Lys Asn 
465                 470                 475                 480 


Thr Asp Thr Met Ala Ser Lys Leu Glu Glu Gln Arg Val Phe Met Val 
                485                 490                 495     


Ala Leu Ser Gln Gly Glu Ala Ile Leu Glu Asn Asp Glu Gln Tyr Ala 
            500                 505                 510         


Phe Ala Ala Gly Gln Val Ile Tyr Tyr Leu Leu His Lys Ser Lys Thr 
        515                 520                 525             


Ala Asp Lys Ser Tyr Lys Arg Leu Glu Pro Phe Leu Gln Gln Val His 
    530                 535                 540                 


Ala Ser Glu Leu Asn Lys Ala Ile Ala Arg Leu Phe Asp Thr Tyr Lys 
545                 550                 555                 560 


His Glu Asn Phe Ser Gly Asn Phe Arg His Pro Phe Ala Ser Val Met 
                565                 570                 575     


Ala Tyr Gln Thr Gln Ala Asn Met Arg Asp Tyr Leu Pro Met Met Leu 
            580                 585                 590         


Ala Gly Ile Phe Ser Asp Asn Leu Leu Phe Ser Val Asn Lys Ser Glu 
        595                 600                 605             


Glu Thr Asn Glu Glu Asn 
    610                 


<210>  250
<211>  312
<212>  PRT
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(312)
<223>  Cas7

<400>  250

Met Ser Asn Thr Phe Lys Asn Arg Val Phe Gly Cys Val Val Ile Lys 
1               5                   10                  15      


Ser Val Asn Ser Asn Tyr Asn Ala Asp Phe Ser His Gln Pro Arg Thr 
            20                  25                  30          


Leu Pro Asp Gly Ser Val Tyr Ala Thr Asp Lys Ala Leu Lys Tyr Thr 
        35                  40                  45              


Val Arg Asn Tyr Ile Asp Lys Asn Tyr Pro Glu Asp Lys Val Phe Tyr 
    50                  55                  60                  


Phe Lys Ser Leu Asn Gly Asp Met Gln Pro Arg Asp Leu Asp Gln Asn 
65                  70                  75                  80  


Tyr Ala Arg Phe Phe Gly Asp Tyr Pro Lys Ala Asp Lys Lys Glu Ala 
                85                  90                  95      


Val Lys Ala Arg Lys Val Ile Leu Gly Asn Leu Leu Ser Cys Leu Asp 
            100                 105                 110         


Val Arg Leu Phe Gly Gly Thr Phe Ala Ser Lys Thr Ala Asn Leu Ser 
        115                 120                 125             


Ile His Gly Val Val Gln Pro Thr His Gly Val Asn Arg Tyr Val Glu 
    130                 135                 140                 


Gly Ile Ile Tyr Ser Glu Gln Ile Ala Ser Pro Phe Arg Asn Ser Asn 
145                 150                 155                 160 


Asp Asn Ser Thr Asp Ser Met Gln Thr Thr Leu Gly Thr Gln Phe Lys 
                165                 170                 175     


Leu Gln Glu Gly His Tyr Val His His Phe Ser Val Asn Pro Gly Asn 
            180                 185                 190         


Leu Asp Glu Leu Thr Glu Phe Val Asp Asn Gly Arg Leu Thr Gly Glu 
        195                 200                 205             


Asp Ile Ala Lys Leu Lys Glu Ala Leu Arg Cys Gly Val Thr Tyr Tyr 
    210                 215                 220                 


Asp Ser Ser Ser Lys Ala Gly Thr Glu Asn Glu Ala Leu Leu Trp Val 
225                 230                 235                 240 


Glu Leu Lys Glu Glu Ser Lys Leu Val Leu Pro Ser Phe Val Asp Leu 
                245                 250                 255     


Ile Glu Val Asn Ala Glu Arg Glu Ile Asp Phe Ala Lys Val Ser Thr 
            260                 265                 270         


Leu Leu Ser Lys Glu Lys Ile Lys Asn Glu Ile Ser Lys Ile Glu Leu 
        275                 280                 285             


Phe Tyr Asn Lys Gly Ile Thr Lys Val Ile His Leu Pro Glu Gly Thr 
    290                 295                 300                 


Val Glu Leu Glu Leu Asn Gly Leu 
305                 310         


<210>  251
<211>  259
<212>  PRT
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(259)
<223>  Cas5

<400>  251

Met Asn Asn Gln Arg Leu Ile Ser Phe Asp Ile Gln Ala Asp Phe Gly 
1               5                   10                  15      


Phe Phe Lys Lys Pro Asp Tyr Asn Asp Gly Val Leu Leu Thr Tyr Asn 
            20                  25                  30          


Met Leu His Lys Pro Ala Leu Leu Gly Ile Leu Gly Ala Ile Ile Gly 
        35                  40                  45              


Leu Arg Gly Tyr Arg Lys Lys Gly Glu Trp Pro Glu Tyr Tyr Gln Arg 
    50                  55                  60                  


Leu Ala Ala Leu Pro Val Gly Ile Glu Pro Leu Glu Gly Arg His Glu 
65                  70                  75                  80  


Lys Gly Asn Phe Gln Lys Thr Ile Val Lys Tyr Thr Asn Thr Val Gly 
                85                  90                  95      


Tyr Ala Asn Gln Asp Gly Asn Leu Leu Val Glu Glu Ser Met Leu Ile 
            100                 105                 110         


Arg Pro Ala Tyr Arg Cys Tyr Leu Leu Leu Ser Glu Glu His Pro Asp 
        115                 120                 125             


His Arg Lys Leu Tyr Glu Tyr Ile Arg Glu Gly Trp Ala Glu Tyr Ile 
    130                 135                 140                 


Pro Tyr Leu Gly Lys Asn Glu Tyr Pro Ala Trp Phe Gly Asp Ser Phe 
145                 150                 155                 160 


Arg Glu Tyr Ala Phe Lys Thr Phe Val Pro Glu Thr Asp Phe Arg Val 
                165                 170                 175     


Ser Ser Leu Phe Ile Lys Glu Gly Val Leu Lys Gly Gln Gln Val Lys 
            180                 185                 190         


Ala Ser Phe Ser Phe Ser Leu Lys Gly Ile Val Asn Arg Gly Ser Phe 
        195                 200                 205             


Val Tyr Phe Glu Arg Leu Pro Val Gly Phe His Pro Val Leu Met Gln 
    210                 215                 220                 


Tyr Glu Leu Ala Asp Phe Ala Phe Thr Asp Trp Thr Leu Gln Ala Ala 
225                 230                 235                 240 


Thr Gln Met Val Asn Leu Tyr Gln Leu Glu Glu Glu Gly Lys Ile Val 
                245                 250                 255     


Gln Leu Phe 
            


<210>  252
<211>  97
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  CRISPR

<400>  252
cttttaattg aactaaggta gaattgaaac taggaataaa ccgtacccaa ccacgtagcc       60

atatacgctt ttaattgaac taaggtagaa ttgaaac                                97


<210>  253
<211>  711
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(711)
<223>  Cas5

<400>  253
atgagaaacg aagtccaatt tgagctattt ggagactacg cgctttttac cgatccgctc       60

acgaagattg gtggggagaa gctttcctac agtgtcccta cctatcaagc gttgaaagga      120

attgccgaaa gcatctactg gaagccgacg attgtctttg ttatcgatga gcttcgggtg      180

atgaagccga ttcagatgga gtctaaaggg gtgcgtccga ttgaatatgg cgggggtaat      240

acgcttgccc attatacgta tttaaaagat gtgcattatc aggtaaaggc ccattttgaa      300

ttcaatcttc accgacctga cttggcgttt gaccgcaatg aagggaagca ttacagcatt      360

cttcagcgtt ctttgaaagc tggggggcgg agagatattt ttcttggggc gagagagtgc      420

caaggatatg tagctccgtg tgagtttggg agtggcgacg gtttttatga tggacaaggg      480

aagtatcatt taggaacgat ggttcatgga tttaactatc ctgatgagac gggtcaacat      540

cagcttgatg tgcgtttatg gtctgctgta atggagaatg ggtacatcca atttccaagg      600

cccgaagact gtccgattgt ccgacctgtg aaagagatgg agcccaaaat ctttaatcca      660

gacaatgttc aatctgccga gcaattactc catgacttag gaggtgagtg a               711


<210>  254
<211>  1884
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(1884)
<223>  Cas8

<400>  254
atgagttggt tgcttcacct atacgaaacc tatgaagcca atctcgatca ggttgggaaa       60

acggtgaaaa agggagagga tcgagaatac acattgctgc cgatctccca tacgacccaa      120

aatgctcata tcgaagtaac acttgacgaa gatggcgact ttctaagagc aaaagcatta      180

acgaaagaga gcacgttaat cccttgtaca gaagaggctg ccagtcgctc aggttcaaag      240

gttgcaccgt accctcttca cgataagctt agctatgttg ctggtgattt tgtcaaatac      300

ggaggaaaga tcaaaaatca agacgatgct ccttttgaca cctatataaa aaatttaggt      360

gagtgggcca attccccgta tgcgacggag aaggtgaagt gcatttatac gtatttgaaa      420

aaagggcgat tgattgaaga cttggtcgac gcaggtgtcc ttaagctcga tgaaaaccaa      480

caattgatcg aaaaatggga aaagcgatat gaagagctac tgggggaaaa gcccgctatt      540

ttttcaagtg gtgctaccga tcaagcgagt gcttttgtga gattcaatgt ttttcaccct      600

gagtcgatcg acgatgtttg gaaagacaaa gagatgtttg attcatttat ttctttttat      660

aatgacaaat taggcgaaga ggatatttgt ttcgtcacag ggaacaggct tcctagcaca      720

gaacgccatg caaataagat ccgtcatgcg gcggataagg caaaattaat atcagctaat      780

gataactctg gttttacctt ccgtgggcga tttaaaacaa gtcgagaagc cgtgggcatt      840

agctatgagg tttctcaaaa ggcccataat gctttgaaat ggctcattca tcgccaaagt      900

aaaagcattg atgatcgtgt gtttcttgtt tggagtaatg ataacagtct tgtgcctaac      960

ccagatgagg atgcggtaga catcatgaag catgccaacc gtgagttaga aagagatcca     1020

gatacagggc aaatttttgc aggtgaagtt aagaaagcga tcggcggcta tcggagtgac     1080

ttgaactatc aaccagaggt tcatattctc gttcttgatt cagcaacgac tgggagaatg     1140

gccgttcttt attatcgaag tctcaataaa gaactctatt tgaatcgttt agaggcgtgg     1200

catgattcgt gtgcatggga gcaccggtat cgaagggacg aaaaggagtt tatttcgttt     1260

tatggggcac ctgcaacgaa ggatattgca tttgccgctt atggaccgag agcgagtgaa     1320

aaggtcataa aagacttaat ggaacgaatg cttccttgta ttgtcgatgg gcgtcgggtc     1380

ccaaaggata ttgttagaag tgccttccaa cgggcttcaa atccggtctc gatggagcgc     1440

tgggaatggg aaaaaacatt aagtatcaca tgtgccctta ttagaaaaat gcacattgaa     1500

caaaaggagg aatggggcgt gccacttgat aaaagctcaa cggaccgcag ctacttgttt     1560

ggacgcttgc tggctgttgc tgatgtgttg gagcgagggg ctctcggtaa ggacgaaaca     1620

agagctacca atgctattcg ttatatgaac tcatattcaa aaaatccagg acgtacgtgg     1680

aaaacgattc aggaaagctt gcagccgtac caagccaaac tcggaactaa agcgacttat     1740

ttatcaaagc tagtcgacga gatcggcgat caatttgagc caggggactt taacaacaac     1800

cctctgacgg aacaatattt gcttgggttt tatagtcaac gtcgtgagct ttataagaaa     1860

aaagaggagg agaccaacca atga                                            1884


<210>  255
<211>  852
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(852)
<223>  Cas7

<400>  255
atgactatac ttgaccacaa aattgatttt gctgttattc tatctgttac taaagccaat       60

ccgaatggag atccccttaa cggaaaccgc ccacgtcaaa attacgatgg gcatggggag      120

atttctgatg ttgcgatcaa gcgtaaaatt cgcaatcgtt tgctagatat ggaagaacct      180

atttttgttc aatctgatga ccgtaaagca gattctttta aaagtttgcg agatcgtgca      240

gattcgaatc ctgagttagc caaaatgctg aaagcaaaaa atgcgtctgt tgatgaattt      300

gcaaaaattg cttgtcaaga gtggatggat gtgcgtagtt ttggacaagt atttgcgttt      360

aaaggctcca atttatccgt tggtgttcgc ggtcctgtgt cgattcacac agcaacgagc      420

attgatccta ttgatattgt tagcacccag attacaaaaa gtgttaactc ggtcacgggt      480

gataaacgta gctcagacac catgggaatg aagcaccgtg tcgactttgg tgtttatgtg      540

ttcaaaggga gcattaacac gcagcttgca gagaaaacag gctttacgaa tgaagatgcg      600

gaaaaaatca agcgggcact catcaccctg tttgaaaatg acagctcttc cgcccgccct      660

gatgggagca tggaggtcca taaagtgtac tggtgggagc attcttcaaa gcttggacaa      720

tattcttctg ccaaagtgca tcgttcatta aaaattgaat caaagacgga tacacctaag      780

agttttgatg attatgccgt tgaactatat gaattagatg gcttgggtgt tgaagtgatt      840

gatggccagt aa                                                          852


<210>  256
<211>  711
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(711)
<223>  Cas5

<400>  256
atgcggaacg aggtgcagtt tgagctgttc ggcgattacg ccctgtttac cgaccccctg       60

acaaagatcg gcggcgagaa gctgtcctac tctgtgccta cctatcaggc cctgaagggc      120

atcgccgagt ccatctattg gaagccaaca atcgtgttcg tgatcgatga gctgagagtg      180

atgaagccca tccagatgga gtctaagggc gtgaggccta tcgagtatgg cggcggcaac      240

accctggccc actacacata tctgaaggac gtgcactacc aggtgaaggc ccacttcgag      300

tttaatctgc acagacccga tctggccttt gacaggaacg agggcaagca ctactctatc      360

ctgcagcgca gcctgaaggc aggaggccgg agagacatct tcctgggagc aagggagtgc      420

cagggatatg tggccccttg tgagtttggc tctggcgatg gcttctacga cggccagggc      480

aagtatcacc tgggcaccat ggtgcacggc ttcaattacc cagatgagac aggccagcac      540

cagctggacg tgaggctgtg gtccgccgtg atggagaacg gctatatcca gtttcctaga      600

ccagaggatt gccccatcgt gaggcctgtg aaggagatgg agccaaagat cttcaatccc      660

gataacgtgc agagcgccga gcagctgctg cacgacctgg gaggagagta a               711


<210>  257
<211>  1884
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(1884)
<223>  Cas8

<400>  257
atgagctggc tgctgcacct gtacgagaca tatgaggcca atctggatca agtgggcaag       60

accgtgaaga agggcgagga cagagagtac acactgctgc caatctccca caccacacag      120

aacgcccaca tcgaggtgac cctggacgag gatggcgact tcctgagggc caaggccctg      180

accaaggagt ctacactgat cccatgcaca gaggaggcag cctcccgctc tggcagcaag      240

gtggcaccat accctctgca cgataagctg agctatgtgg ccggcgactt tgtgaagtac      300

ggcggcaaga tcaagaatca ggacgatgcc ccattcgaca cctatatcaa gaatctggga      360

gagtgggcaa acagcccata cgcaaccgag aaggtgaagt gtatctacac atatctgaag      420

aagggccgcc tgatcgagga tctggtggac gccggcgtgc tgaagctgga tgagaaccag      480

cagctgatcg agaagtggga gaagcggtac gaggagctgc tgggcgagaa gcctgccatc      540

tttagctccg gcgcaaccga ccaggccagc gccttcgtgc ggttcaacgt gttccaccca      600

gagtccatcg acgacgtgtg gaaggataag gagatgttcg actcctttat ctctttctat      660

aacgataagc tgggcgagga ggacatctgc ttcgtgaccg gcaatcggct gcccagcaca      720

gagagacacg ccaacaagat caggcacgcc gccgataagg ccaagctgat cagcgccaat      780

gacaactccg gctttacctt ccggggccgg ttcaagacca gccgggaggc agtgggaatc      840

agctacgagg tgtcccagaa ggcccacaat gccctgaagt ggctgatcca ccgccagtcc      900

aagtctatcg acgatcgggt gttcctggtg tggtctaatg ataacagcct ggtgccaaat      960

cccgatgagg acgccgtgga catcatgaag cacgccaaca gggagctgga gcgcgatcca     1020

gacaccggac agatcttcgc aggagaggtg aagaaggcaa tcggaggcta ccgcagcgat     1080

ctgaactatc agcccgaggt gcacatcctg gtgctggact ctgccaccac aggccgcatg     1140

gccgtgctgt actatcggag cctgaataag gagctgtacc tgaaccgcct ggaggcctgg     1200

cacgattctt gtgcctggga gcaccggtat cggagagacg agaaggagtt tatcagcttc     1260

tacggcgccc ccgccaccaa ggatatcgcc tttgccgcat atggacctag ggcctccgag     1320

aaagtgatca aggacctgat ggagcggatg ctgccttgca tcgtggatgg caggcgcgtg     1380

ccaaaggaca tcgtgcggag cgccttccag agagcctcca atcccgtgtc tatggagaga     1440

tgggagtggg agaagaccct gtccatcaca tgtgccctga tcaggaagat gcacatcgag     1500

cagaaggagg agtggggcgt gcctctggat aagtctagca ccgaccgcag ctacctgttt     1560

ggccggctgc tggccgtggc agatgtgctg gagaggggcg ccctgggcaa ggacgagacc     1620

agagccacaa acgccatcag gtacatgaat agctattcca agaaccctgg ccgcacctgg     1680

aagacaatcc aggagtccct gcagccatat caggccaagc tgggcaccaa ggccacatac     1740

ctgtctaagc tggtggatga gatcggcgac cagtttgagc ctggcgactt caacaataac     1800

ccactgaccg agcagtacct gctgggcttc tatagccagc ggagagagct gtacaagaag     1860

aaggaggagg agacaaacca gtaa                                            1884


<210>  258
<211>  852
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(852)
<223>  Cas7

<400>  258
atgaccatcc tggatcacaa gatcgacttc gccgtgatcc tgtccgtgac aaaggccaat       60

cctaacggcg acccactgaa tggcaacagg cctcgccaga attacgatgg ccacggcgag      120

atctctgacg tggccatcaa gagaaagatc agaaacagac tgctggatat ggaggagccc      180

atctttgtgc agagcgacga taggaaggcc gactctttca agagcctgag ggatcgcgcc      240

gactccaatc ctgagctggc caagatgctg aaggccaaga acgcctctgt ggatgagttt      300

gccaagatcg cctgccagga gtggatggac gtgcgctcct tcggccaggt gttcgccttt      360

aagggctcca atctgtctgt gggcgtgcgg ggacccgtga gcatccacac cgccacaagc      420

atcgatccaa tcgacatcgt gtctacccag atcacaaaga gcgtgaactc cgtgaccggc      480

gataagagaa gctccgacac aatgggcatg aagcacaggg tggattttgg cgtgtacgtg      540

ttcaagggct ccatcaatac ccagctggcc gagaagaccg gctttacaaa cgaggacgcc      600

gagaagatca agagagccct gatcacactg ttcgagaacg attctagctc cgccaggcct      660

gacggctcca tggaggtgca caaggtgtat tggtgggagc actctagcaa gctgggccag      720

tactcctctg ccaaggtgca ccggagcctg aagatcgagt ccaagaccga tacaccaaag      780

agcttcgacg attacgccgt ggagctgtat gagctggatg gcctgggcgt ggaagtgatc      840

gacggacagt aa                                                          852


<210>  259
<211>  236
<212>  PRT
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(236)
<223>  Cas5

<400>  259

Met Arg Asn Glu Val Gln Phe Glu Leu Phe Gly Asp Tyr Ala Leu Phe 
1               5                   10                  15      


Thr Asp Pro Leu Thr Lys Ile Gly Gly Glu Lys Leu Ser Tyr Ser Val 
            20                  25                  30          


Pro Thr Tyr Gln Ala Leu Lys Gly Ile Ala Glu Ser Ile Tyr Trp Lys 
        35                  40                  45              


Pro Thr Ile Val Phe Val Ile Asp Glu Leu Arg Val Met Lys Pro Ile 
    50                  55                  60                  


Gln Met Glu Ser Lys Gly Val Arg Pro Ile Glu Tyr Gly Gly Gly Asn 
65                  70                  75                  80  


Thr Leu Ala His Tyr Thr Tyr Leu Lys Asp Val His Tyr Gln Val Lys 
                85                  90                  95      


Ala His Phe Glu Phe Asn Leu His Arg Pro Asp Leu Ala Phe Asp Arg 
            100                 105                 110         


Asn Glu Gly Lys His Tyr Ser Ile Leu Gln Arg Ser Leu Lys Ala Gly 
        115                 120                 125             


Gly Arg Arg Asp Ile Phe Leu Gly Ala Arg Glu Cys Gln Gly Tyr Val 
    130                 135                 140                 


Ala Pro Cys Glu Phe Gly Ser Gly Asp Gly Phe Tyr Asp Gly Gln Gly 
145                 150                 155                 160 


Lys Tyr His Leu Gly Thr Met Val His Gly Phe Asn Tyr Pro Asp Glu 
                165                 170                 175     


Thr Gly Gln His Gln Leu Asp Val Arg Leu Trp Ser Ala Val Met Glu 
            180                 185                 190         


Asn Gly Tyr Ile Gln Phe Pro Arg Pro Glu Asp Cys Pro Ile Val Arg 
        195                 200                 205             


Pro Val Lys Glu Met Glu Pro Lys Ile Phe Asn Pro Asp Asn Val Gln 
    210                 215                 220                 


Ser Ala Glu Gln Leu Leu His Asp Leu Gly Gly Glu 
225                 230                 235     


<210>  260
<211>  627
<212>  PRT
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(627)
<223>  Cas8

<400>  260

Met Ser Trp Leu Leu His Leu Tyr Glu Thr Tyr Glu Ala Asn Leu Asp 
1               5                   10                  15      


Gln Val Gly Lys Thr Val Lys Lys Gly Glu Asp Arg Glu Tyr Thr Leu 
            20                  25                  30          


Leu Pro Ile Ser His Thr Thr Gln Asn Ala His Ile Glu Val Thr Leu 
        35                  40                  45              


Asp Glu Asp Gly Asp Phe Leu Arg Ala Lys Ala Leu Thr Lys Glu Ser 
    50                  55                  60                  


Thr Leu Ile Pro Cys Thr Glu Glu Ala Ala Ser Arg Ser Gly Ser Lys 
65                  70                  75                  80  


Val Ala Pro Tyr Pro Leu His Asp Lys Leu Ser Tyr Val Ala Gly Asp 
                85                  90                  95      


Phe Val Lys Tyr Gly Gly Lys Ile Lys Asn Gln Asp Asp Ala Pro Phe 
            100                 105                 110         


Asp Thr Tyr Ile Lys Asn Leu Gly Glu Trp Ala Asn Ser Pro Tyr Ala 
        115                 120                 125             


Thr Glu Lys Val Lys Cys Ile Tyr Thr Tyr Leu Lys Lys Gly Arg Leu 
    130                 135                 140                 


Ile Glu Asp Leu Val Asp Ala Gly Val Leu Lys Leu Asp Glu Asn Gln 
145                 150                 155                 160 


Gln Leu Ile Glu Lys Trp Glu Lys Arg Tyr Glu Glu Leu Leu Gly Glu 
                165                 170                 175     


Lys Pro Ala Ile Phe Ser Ser Gly Ala Thr Asp Gln Ala Ser Ala Phe 
            180                 185                 190         


Val Arg Phe Asn Val Phe His Pro Glu Ser Ile Asp Asp Val Trp Lys 
        195                 200                 205             


Asp Lys Glu Met Phe Asp Ser Phe Ile Ser Phe Tyr Asn Asp Lys Leu 
    210                 215                 220                 


Gly Glu Glu Asp Ile Cys Phe Val Thr Gly Asn Arg Leu Pro Ser Thr 
225                 230                 235                 240 


Glu Arg His Ala Asn Lys Ile Arg His Ala Ala Asp Lys Ala Lys Leu 
                245                 250                 255     


Ile Ser Ala Asn Asp Asn Ser Gly Phe Thr Phe Arg Gly Arg Phe Lys 
            260                 265                 270         


Thr Ser Arg Glu Ala Val Gly Ile Ser Tyr Glu Val Ser Gln Lys Ala 
        275                 280                 285             


His Asn Ala Leu Lys Trp Leu Ile His Arg Gln Ser Lys Ser Ile Asp 
    290                 295                 300                 


Asp Arg Val Phe Leu Val Trp Ser Asn Asp Asn Ser Leu Val Pro Asn 
305                 310                 315                 320 


Pro Asp Glu Asp Ala Val Asp Ile Met Lys His Ala Asn Arg Glu Leu 
                325                 330                 335     


Glu Arg Asp Pro Asp Thr Gly Gln Ile Phe Ala Gly Glu Val Lys Lys 
            340                 345                 350         


Ala Ile Gly Gly Tyr Arg Ser Asp Leu Asn Tyr Gln Pro Glu Val His 
        355                 360                 365             


Ile Leu Val Leu Asp Ser Ala Thr Thr Gly Arg Met Ala Val Leu Tyr 
    370                 375                 380                 


Tyr Arg Ser Leu Asn Lys Glu Leu Tyr Leu Asn Arg Leu Glu Ala Trp 
385                 390                 395                 400 


His Asp Ser Cys Ala Trp Glu His Arg Tyr Arg Arg Asp Glu Lys Glu 
                405                 410                 415     


Phe Ile Ser Phe Tyr Gly Ala Pro Ala Thr Lys Asp Ile Ala Phe Ala 
            420                 425                 430         


Ala Tyr Gly Pro Arg Ala Ser Glu Lys Val Ile Lys Asp Leu Met Glu 
        435                 440                 445             


Arg Met Leu Pro Cys Ile Val Asp Gly Arg Arg Val Pro Lys Asp Ile 
    450                 455                 460                 


Val Arg Ser Ala Phe Gln Arg Ala Ser Asn Pro Val Ser Met Glu Arg 
465                 470                 475                 480 


Trp Glu Trp Glu Lys Thr Leu Ser Ile Thr Cys Ala Leu Ile Arg Lys 
                485                 490                 495     


Met His Ile Glu Gln Lys Glu Glu Trp Gly Val Pro Leu Asp Lys Ser 
            500                 505                 510         


Ser Thr Asp Arg Ser Tyr Leu Phe Gly Arg Leu Leu Ala Val Ala Asp 
        515                 520                 525             


Val Leu Glu Arg Gly Ala Leu Gly Lys Asp Glu Thr Arg Ala Thr Asn 
    530                 535                 540                 


Ala Ile Arg Tyr Met Asn Ser Tyr Ser Lys Asn Pro Gly Arg Thr Trp 
545                 550                 555                 560 


Lys Thr Ile Gln Glu Ser Leu Gln Pro Tyr Gln Ala Lys Leu Gly Thr 
                565                 570                 575     


Lys Ala Thr Tyr Leu Ser Lys Leu Val Asp Glu Ile Gly Asp Gln Phe 
            580                 585                 590         


Glu Pro Gly Asp Phe Asn Asn Asn Pro Leu Thr Glu Gln Tyr Leu Leu 
        595                 600                 605             


Gly Phe Tyr Ser Gln Arg Arg Glu Leu Tyr Lys Lys Lys Glu Glu Glu 
    610                 615                 620                 


Thr Asn Gln 
625         


<210>  261
<211>  283
<212>  PRT
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(283)
<223>  Cas7

<400>  261

Met Thr Ile Leu Asp His Lys Ile Asp Phe Ala Val Ile Leu Ser Val 
1               5                   10                  15      


Thr Lys Ala Asn Pro Asn Gly Asp Pro Leu Asn Gly Asn Arg Pro Arg 
            20                  25                  30          


Gln Asn Tyr Asp Gly His Gly Glu Ile Ser Asp Val Ala Ile Lys Arg 
        35                  40                  45              


Lys Ile Arg Asn Arg Leu Leu Asp Met Glu Glu Pro Ile Phe Val Gln 
    50                  55                  60                  


Ser Asp Asp Arg Lys Ala Asp Ser Phe Lys Ser Leu Arg Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Asn Pro Glu Leu Ala Lys Met Leu Lys Ala Lys Asn Ala Ser 
                85                  90                  95      


Val Asp Glu Phe Ala Lys Ile Ala Cys Gln Glu Trp Met Asp Val Arg 
            100                 105                 110         


Ser Phe Gly Gln Val Phe Ala Phe Lys Gly Ser Asn Leu Ser Val Gly 
        115                 120                 125             


Val Arg Gly Pro Val Ser Ile His Thr Ala Thr Ser Ile Asp Pro Ile 
    130                 135                 140                 


Asp Ile Val Ser Thr Gln Ile Thr Lys Ser Val Asn Ser Val Thr Gly 
145                 150                 155                 160 


Asp Lys Arg Ser Ser Asp Thr Met Gly Met Lys His Arg Val Asp Phe 
                165                 170                 175     


Gly Val Tyr Val Phe Lys Gly Ser Ile Asn Thr Gln Leu Ala Glu Lys 
            180                 185                 190         


Thr Gly Phe Thr Asn Glu Asp Ala Glu Lys Ile Lys Arg Ala Leu Ile 
        195                 200                 205             


Thr Leu Phe Glu Asn Asp Ser Ser Ser Ala Arg Pro Asp Gly Ser Met 
    210                 215                 220                 


Glu Val His Lys Val Tyr Trp Trp Glu His Ser Ser Lys Leu Gly Gln 
225                 230                 235                 240 


Tyr Ser Ser Ala Lys Val His Arg Ser Leu Lys Ile Glu Ser Lys Thr 
                245                 250                 255     


Asp Thr Pro Lys Ser Phe Asp Asp Tyr Ala Val Glu Leu Tyr Glu Leu 
            260                 265                 270         


Asp Gly Leu Gly Val Glu Val Ile Asp Gly Gln 
        275                 280             


<210>  262
<211>  99
<212>  DNA
<213>  Bacillus halodurans C-125


<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  Exemplary minimal CRISPR array

<400>  262
gtcgcactct tcatgggtgc gtggattgaa atcctttgac ggagagggga acaggaaatt       60

agagaaggtc gcactcttca tgggtgcgtg gattgaaat                              99


<210>  263
<211>  684
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(684)
<223>  Cas5, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  263
atgacacatg gggctgttaa gacatacggc atcagactgc gggtatgggg cgactacgcc       60

tgcttcacgc ggccggagat gaaggtggaa cgggtgtcat acgatgtcat gcccccttcc      120

gccgcacggg gcatccttga ggccatccac tggaagccgg ccatcaggtg gattgtggac      180

aggattcatg tgctgcggcc catcgtcttc gacaacgtgc ggcgcaacga ggtcagttcg      240

aagataccca agcccaatcc ggcaacggcc atgcgcgaca ggaagccgct ctactttctg      300

gtcgatgacg gcagcaaccg ccagcaacgg gcggcgaccc tgctgcgcaa cgtcgactat      360

gtcatcgaag cccacttcga actgacagac aaggccggag cggaagacaa cgcgggcaag      420

catctggaca tcttcaggcg tcgtgcgcgc gccgggcagt cgttccagca gccatgcctc      480

ggctgccgcg agtttccggc gtcgttcgaa ctgctggagg gggatgtgcc gctctcgtgc      540

tacgcgggcg agaagcgcga ccttggctac atgctgctcg acatcgactt cgaacgcgac      600

atgacgccgc tgttcttcaa ggccgtcatg gaagacggag tgataacgcc cccgtcgcgc      660

acgtcaccgg aggtgagggc atga                                             684


<210>  264
<211>  1839
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(1839)
<223>  Cas8, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  264
atgatcctgc aggcattgca tggctattac cagcgcatga gcgcagaccc cgatgcgggg       60

atgccgccct acgggaccag catggagaac atctcgttcg cgctggtgct ggatgcgaaa      120

gggacgctac ggggcatcga ggacttgcgg gaacaggaag gcaagaagct gcggccccgc      180

aagatgctgg ttcctatcgc ggaaaagaag gggaacggca tcaaaccgaa cttcctgtgg      240

gagaacacca gttatattct gggggtggac gccaagggca agcaggaacg tacagacaag      300

tgccacgccg cgttcattgc ccacatcaag gcctactgtg acactgcaga ccaagacctt      360

gccgccgttc tgcagttcct tgaacacggc gaaaaagacc tctccgcttt tccggtttcg      420

gaagaggtca tcggctccaa tatcgtcttt cgcatcgagg gcgaaccggg cttcgtccat      480

gagcgtccgg ctgcgcggca ggcttgggcc aactgcctga accggcggga gcaagggcta      540

tgtggtcaat gcctcatcac cggggagcgc cagaagccga ttgcccaact ccatccgtcg      600

atcaaaggcg ggcgagacgg cgttcgcggt gcacaggctg ttgcctcgat agtgtccttt      660

aacaacaccg cctttgaatc ttacgggaaa gaacagtcga tcaatgcacc cgtcagtcaa      720

gaagcggcat tctcttatgt cacagccctg aattacctgc tcaacccgtc aaatcgacag      780

aaggtcacca tcgctgacgc caccgtggtc ttctgggccg aacgcagcag cccggcagag      840

gacatctttg caggcatgtt cgacccgcct tccaccacgg cgaaaccgga gtcctcgaac      900

gggacgccgc cggaagacag tgaagaaggc agccagcctg acacagccag agacgacccc      960

catgccgctg ccagaatgca cgacctgctt gtggccatcc gttccggcaa gcgcgccacg     1020

gacatcatgc ccgacatgga cgagtccgtg cgcttccatg tgcttggcct gtcgcccaac     1080

gccgcccgcc tgtccgtccg cttctgggag gtcgataccg tcggtcacat gctggacaag     1140

gtggggcggc actaccgtga actcgagatc attccgcaat tcaacaacga gcaggagttc     1200

ccgtctcttt caaccctgct gcggcagact gccgtcttga acaagaccga gaacatctcg     1260

cctgtacttg caggcgggct attcagggcc atgctcaccg gcgggcccta tccgcaaagc     1320

ctgttgcccg ccgtgcttgg acgcatccgc gccgagcacg ccagaccaga agataaaagc     1380

cgctataggc ttgaagttgt gacgtattat cgagccgcct tgatcaaggc gtatctcata     1440

agaaacagaa agctggaggt gcccgtgtct ctcgaccccg caagaacaga ccgcccgtac     1500

ctgctcggac gactcttcgc cgttctggaa aaagcgcagg aagatgccgt gcccggtgcg     1560

aacgccacca tcaaggaccg ctatctggcc tccgcatcgg ccaatccggg gcaggtattc     1620

cacatgctgc tcaagaatgc gtccaaccac acggccaaac tccgcaagga ccctgaaaga     1680

aaggggtcgg ccatccacta cgaaatcatg atgcaagaga ttatcgacaa catcagcgat     1740

tttccggtga ccatgtcgtc cgacgaacaa ggcctgttca tgatcggcta ctaccaccag     1800

cgcaaggccc ttttcaccaa gaagaacaag gagaactag                            1839


<210>  265
<211>  873
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(873)
<223>  Cas7, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  265
atgaccgcca ttgccaacag atacgagttc gtgctgcttt tcgatgtgga gaacggcaac       60

cccaacggcg accccgacgc gggcaacatg ccgcgcatcg accccgagac cgggcatggt      120

ctggtcaccg acgtgtgcct gaagcgcaag atacgcaacc atgtggccct gacaaaagaa      180

ggtgccgagc ggttcaatat ctatattcag gaaaaggcca ttctcaacga aacccacgaa      240

cgcgcctaca cggcctgcga cctgaaaccc gaacccaaga aactgcccaa gaaggtcgaa      300

gacgccaaga gggtcaccga ctggatgtgc acgaacttct acgacatccg cacgttcggc      360

gccgtcatga ccacagaggt caactgcggg caggtgcgcg gccccgtgca gatggccttt      420

gccagaagtg tggaacccgt cgtgccgcaa gaggtgagca tcacccgcat ggcagtcacc      480

acgaaggcag aggccgaaaa gcagcaggga gacaaccgca ccatgggtcg caagcacatc      540

gtgccctacg gcctgtatgt ggcgcacggc ttcatctccg caccgctggc agagaagaca      600

ggcttctccg atgaagacct gacgctgttc tgggacgccc tcgtcaacat gttcgagcac      660

gaccgttcgg cggcacgcgg cctcatgagc agccgcaaac tcatcgtctt caagcaccag      720

aacaggctcg gcaacgcccc cgcccacaag ttgttcgacc tcgtgaaggt cagccgtgca      780

gagggttcgt ccggccccgc ccggtcgttt gccgactatg cggtgacagt ggggcaggcc      840

cccgaaggcg tagaggtcaa agagatgctg tag                                   873


<210>  266
<211>  684
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(684)
<223>  Cas5, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  266
atgacccacg gagcagtgaa gacatacggc atcagactga gggtgtgggg cgactatgcc       60

tgttttaccc ggcctgagat gaaggtggag agagtgagct acgatgtgat gccaccatcc      120

gccgcaaggg gcatcctgga ggcaatccac tggaagccag ccatcagatg gatcgtggac      180

agaatccacg tgctgcgccc catcgtgttc gataatgtgc ggagaaacga ggtgtcctct      240

aagatcccta agccaaaccc agcaacagca atgagggata ggaagcccct gtattttctg      300

gtggacgatg gctccaacag gcagcagagg gcagccaccc tgctgcggaa tgtggactac      360

gtgatcgagg cccacttcga gctgacagac aaggccggcg ccgaggataa tgccggcaag      420

cacctggata tcttcaggcg ccgggcaagg gcaggacaga gctttcagca gccttgcctg      480

ggctgtcgcg agtttccagc ctccttcgag ctgctggagg gcgacgtgcc actgtcttgc      540

tacgcaggcg agaagcggga tctgggctat atgctgctgg acatcgattt cgagagagac      600

atgaccccac tgttctttaa ggccgtgatg gaggatggcg tgatcacccc tccatctagg      660

acaagccccg aggtgcgcgc ataa                                             684


<210>  267
<211>  1839
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(1839)
<223>  Cas8, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  267
atgatcctgc aggccctgca cggatactat cagagaatgt ccgccgaccc tgatgcagga       60

atgccaccct acggcaccag catggagaat atctccttcg ccctggtgct ggacgccaag      120

ggcacactga ggggcatcga ggatctgcgc gagcaggagg gcaagaagct gagaccaagg      180

aagatgctgg tgcccatcgc cgagaagaag ggcaatggca tcaagccaaa ctttctgtgg      240

gagaatacca gctatatcct gggcgtggac gccaagggca agcaggagag gaccgataag      300

tgccacgccg ccttcatcgc ccacatcaag gcctactgtg acaccgcaga ccaggatctg      360

gcagccgtgc tgcagttcct ggagcacggc gagaaggatc tgtctgcctt tcccgtgagc      420

gaggaagtga tcggctccaa catcgtgttc agaatcgagg gcgagcccgg ctttgtgcac      480

gagagacctg cagcaaggca ggcctgggcc aattgtctga acaggaggga gcagggactg      540

tgcggacagt gtctgatcac cggcgagagg cagaagccta tcgcccagct gcacccaagc      600

atcaagggag gaagggacgg cgtgcgggga gcacaggccg tggccagcat cgtgtccttt      660

aacaataccg ccttcgagtc ttacggcaag gagcagagca tcaacgcacc cgtgtcccag      720

gaggcagcct tttcttacgt gacagccctg aattatctgc tgaatccttc caacaggcag      780

aaggtgacca tcgccgatgc cacagtggtg ttctgggcag agcgcagctc cccagcagag      840

gacatctttg ccggcatgtt cgatcctcca tctaccacag ccaagcccga gtctagcaac      900

ggaacccccc ctgaggactc tgaggagggc agccagccag atacagcaag ggacgatcca      960

cacgcagcag caaggatgca cgacctgctg gtggccatca gatctggcaa gagggccacc     1020

gatatcatgc ccgacatgga tgagagcgtg agatttcacg tgctgggcct gtctcctaat     1080

gcagcaaggc tgagcgtgcg gttctgggag gtggacacag tgggccacat gctggataaa     1140

gtgggcagac actataggga gctggagatc atccctcagt ttaacaatga gcaggagttc     1200

ccatccctgt ctaccctgct gagacagaca gccgtgctga ataagaccga gaacatctct     1260

ccagtgctgg ccggaggact gttcagggca atgctgacag gaggacctta cccacagagc     1320

ctgctgccag ccgtgctggg acgcatccgg gcagagcacg cacggcctga ggacaagtcc     1380

agatacaggc tggaggtggt gacctactat agagccgccc tgatcaaggc ctatctgatc     1440

cgcaaccgga agctggaggt gcccgtgtcc ctggaccctg caaggaccga taggccatat     1500

ctgctgggcc gcctgtttgc cgtgctggag aaggcacagg aggacgcagt gcctggagcc     1560

aacgccacaa tcaaggatcg gtacctggcc agcgcctccg ccaatccagg acaggtgttc     1620

cacatgctgc tgaagaatgc ctccaaccac accgccaagc tgcggaagga ccctgagaga     1680

aagggctctg ccatccacta cgagatcatg atgcaggaga tcatcgacaa tatcagcgat     1740

ttcccagtga ccatgtcctc tgatgagcag ggcctgttta tgatcggcta ctatcaccag     1800

aggaaggccc tgttcacaaa gaagaataag gagaactaa                            1839


<210>  268
<211>  873
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(873)
<223>  Cas7, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  268
atgaccgcaa tcgcaaaccg ctatgagttt gtgctgctgt tcgacgtgga gaacggcaat       60

ccaaacggcg accccgatgc cggcaatatg cctaggatcg acccagagac cggacacgga      120

ctggtgacag acgtgtgcct gaagagaaag atcaggaacc acgtggccct gacaaaggag      180

ggcgccgaga ggttcaacat ctacatccag gagaaggcca tcctgaatga gacccacgag      240

cgcgcctata cagcctgtga cctgaagcca gagcccaaga agctgccaaa gaaggtggag      300

gacgccaagc gggtgaccga ttggatgtgc acaaactttt acgatatcag aaccttcggc      360

gccgtgatga ccacagaagt gaattgtgga caggtgcggg gaccagtgca gatggccttt      420

gccagatccg tggagcccgt ggtgcctcag gaggtgtcta tcacccggat ggccgtgacc      480

acaaaggccg aggccgagaa gcagcagggc gacaacagaa caatgggcag gaagcacatc      540

gtgccatacg gcctgtatgt ggcacacggc ttcatcagcg cccccctggc cgagaagacc      600

ggcttttccg acgaggatct gacactgttc tgggacgccc tggtgaatat gtttgagcac      660

gatcgctccg ccgcaagggg actgatgagc tcccggaagc tgatcgtgtt taagcaccag      720

aatagactgg gcaacgcccc tgcccacaag ctgttcgacc tggtgaaggt gtctagggca      780

gagggctcta gcggccctgc acgcagcttc gccgattatg cagtgaccgt gggacaggcc      840

ccagagggag tggaggtgaa ggagatgctg taa                                   873


<210>  269
<211>  227
<212>  PRT
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(227)
<223>  Cas5, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  269

Met Thr His Gly Ala Val Lys Thr Tyr Gly Ile Arg Leu Arg Val Trp 
1               5                   10                  15      


Gly Asp Tyr Ala Cys Phe Thr Arg Pro Glu Met Lys Val Glu Arg Val 
            20                  25                  30          


Ser Tyr Asp Val Met Pro Pro Ser Ala Ala Arg Gly Ile Leu Glu Ala 
        35                  40                  45              


Ile His Trp Lys Pro Ala Ile Arg Trp Ile Val Asp Arg Ile His Val 
    50                  55                  60                  


Leu Arg Pro Ile Val Phe Asp Asn Val Arg Arg Asn Glu Val Ser Ser 
65                  70                  75                  80  


Lys Ile Pro Lys Pro Asn Pro Ala Thr Ala Met Arg Asp Arg Lys Pro 
                85                  90                  95      


Leu Tyr Phe Leu Val Asp Asp Gly Ser Asn Arg Gln Gln Arg Ala Ala 
            100                 105                 110         


Thr Leu Leu Arg Asn Val Asp Tyr Val Ile Glu Ala His Phe Glu Leu 
        115                 120                 125             


Thr Asp Lys Ala Gly Ala Glu Asp Asn Ala Gly Lys His Leu Asp Ile 
    130                 135                 140                 


Phe Arg Arg Arg Ala Arg Ala Gly Gln Ser Phe Gln Gln Pro Cys Leu 
145                 150                 155                 160 


Gly Cys Arg Glu Phe Pro Ala Ser Phe Glu Leu Leu Glu Gly Asp Val 
                165                 170                 175     


Pro Leu Ser Cys Tyr Ala Gly Glu Lys Arg Asp Leu Gly Tyr Met Leu 
            180                 185                 190         


Leu Asp Ile Asp Phe Glu Arg Asp Met Thr Pro Leu Phe Phe Lys Ala 
        195                 200                 205             


Val Met Glu Asp Gly Val Ile Thr Pro Pro Ser Arg Thr Ser Pro Glu 
    210                 215                 220                 


Val Arg Ala 
225         


<210>  270
<211>  612
<212>  PRT
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(612)
<223>  Cas8, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  270

Met Ile Leu Gln Ala Leu His Gly Tyr Tyr Gln Arg Met Ser Ala Asp 
1               5                   10                  15      


Pro Asp Ala Gly Met Pro Pro Tyr Gly Thr Ser Met Glu Asn Ile Ser 
            20                  25                  30          


Phe Ala Leu Val Leu Asp Ala Lys Gly Thr Leu Arg Gly Ile Glu Asp 
        35                  40                  45              


Leu Arg Glu Gln Glu Gly Lys Lys Leu Arg Pro Arg Lys Met Leu Val 
    50                  55                  60                  


Pro Ile Ala Glu Lys Lys Gly Asn Gly Ile Lys Pro Asn Phe Leu Trp 
65                  70                  75                  80  


Glu Asn Thr Ser Tyr Ile Leu Gly Val Asp Ala Lys Gly Lys Gln Glu 
                85                  90                  95      


Arg Thr Asp Lys Cys His Ala Ala Phe Ile Ala His Ile Lys Ala Tyr 
            100                 105                 110         


Cys Asp Thr Ala Asp Gln Asp Leu Ala Ala Val Leu Gln Phe Leu Glu 
        115                 120                 125             


His Gly Glu Lys Asp Leu Ser Ala Phe Pro Val Ser Glu Glu Val Ile 
    130                 135                 140                 


Gly Ser Asn Ile Val Phe Arg Ile Glu Gly Glu Pro Gly Phe Val His 
145                 150                 155                 160 


Glu Arg Pro Ala Ala Arg Gln Ala Trp Ala Asn Cys Leu Asn Arg Arg 
                165                 170                 175     


Glu Gln Gly Leu Cys Gly Gln Cys Leu Ile Thr Gly Glu Arg Gln Lys 
            180                 185                 190         


Pro Ile Ala Gln Leu His Pro Ser Ile Lys Gly Gly Arg Asp Gly Val 
        195                 200                 205             


Arg Gly Ala Gln Ala Val Ala Ser Ile Val Ser Phe Asn Asn Thr Ala 
    210                 215                 220                 


Phe Glu Ser Tyr Gly Lys Glu Gln Ser Ile Asn Ala Pro Val Ser Gln 
225                 230                 235                 240 


Glu Ala Ala Phe Ser Tyr Val Thr Ala Leu Asn Tyr Leu Leu Asn Pro 
                245                 250                 255     


Ser Asn Arg Gln Lys Val Thr Ile Ala Asp Ala Thr Val Val Phe Trp 
            260                 265                 270         


Ala Glu Arg Ser Ser Pro Ala Glu Asp Ile Phe Ala Gly Met Phe Asp 
        275                 280                 285             


Pro Pro Ser Thr Thr Ala Lys Pro Glu Ser Ser Asn Gly Thr Pro Pro 
    290                 295                 300                 


Glu Asp Ser Glu Glu Gly Ser Gln Pro Asp Thr Ala Arg Asp Asp Pro 
305                 310                 315                 320 


His Ala Ala Ala Arg Met His Asp Leu Leu Val Ala Ile Arg Ser Gly 
                325                 330                 335     


Lys Arg Ala Thr Asp Ile Met Pro Asp Met Asp Glu Ser Val Arg Phe 
            340                 345                 350         


His Val Leu Gly Leu Ser Pro Asn Ala Ala Arg Leu Ser Val Arg Phe 
        355                 360                 365             


Trp Glu Val Asp Thr Val Gly His Met Leu Asp Lys Val Gly Arg His 
    370                 375                 380                 


Tyr Arg Glu Leu Glu Ile Ile Pro Gln Phe Asn Asn Glu Gln Glu Phe 
385                 390                 395                 400 


Pro Ser Leu Ser Thr Leu Leu Arg Gln Thr Ala Val Leu Asn Lys Thr 
                405                 410                 415     


Glu Asn Ile Ser Pro Val Leu Ala Gly Gly Leu Phe Arg Ala Met Leu 
            420                 425                 430         


Thr Gly Gly Pro Tyr Pro Gln Ser Leu Leu Pro Ala Val Leu Gly Arg 
        435                 440                 445             


Ile Arg Ala Glu His Ala Arg Pro Glu Asp Lys Ser Arg Tyr Arg Leu 
    450                 455                 460                 


Glu Val Val Thr Tyr Tyr Arg Ala Ala Leu Ile Lys Ala Tyr Leu Ile 
465                 470                 475                 480 


Arg Asn Arg Lys Leu Glu Val Pro Val Ser Leu Asp Pro Ala Arg Thr 
                485                 490                 495     


Asp Arg Pro Tyr Leu Leu Gly Arg Leu Phe Ala Val Leu Glu Lys Ala 
            500                 505                 510         


Gln Glu Asp Ala Val Pro Gly Ala Asn Ala Thr Ile Lys Asp Arg Tyr 
        515                 520                 525             


Leu Ala Ser Ala Ser Ala Asn Pro Gly Gln Val Phe His Met Leu Leu 
    530                 535                 540                 


Lys Asn Ala Ser Asn His Thr Ala Lys Leu Arg Lys Asp Pro Glu Arg 
545                 550                 555                 560 


Lys Gly Ser Ala Ile His Tyr Glu Ile Met Met Gln Glu Ile Ile Asp 
                565                 570                 575     


Asn Ile Ser Asp Phe Pro Val Thr Met Ser Ser Asp Glu Gln Gly Leu 
            580                 585                 590         


Phe Met Ile Gly Tyr Tyr His Gln Arg Lys Ala Leu Phe Thr Lys Lys 
        595                 600                 605             


Asn Lys Glu Asn 
    610         


<210>  271
<211>  290
<212>  PRT
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(290)
<223>  Cas7, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  271

Met Thr Ala Ile Ala Asn Arg Tyr Glu Phe Val Leu Leu Phe Asp Val 
1               5                   10                  15      


Glu Asn Gly Asn Pro Asn Gly Asp Pro Asp Ala Gly Asn Met Pro Arg 
            20                  25                  30          


Ile Asp Pro Glu Thr Gly His Gly Leu Val Thr Asp Val Cys Leu Lys 
        35                  40                  45              


Arg Lys Ile Arg Asn His Val Ala Leu Thr Lys Glu Gly Ala Glu Arg 
    50                  55                  60                  


Phe Asn Ile Tyr Ile Gln Glu Lys Ala Ile Leu Asn Glu Thr His Glu 
65                  70                  75                  80  


Arg Ala Tyr Thr Ala Cys Asp Leu Lys Pro Glu Pro Lys Lys Leu Pro 
                85                  90                  95      


Lys Lys Val Glu Asp Ala Lys Arg Val Thr Asp Trp Met Cys Thr Asn 
            100                 105                 110         


Phe Tyr Asp Ile Arg Thr Phe Gly Ala Val Met Thr Thr Glu Val Asn 
        115                 120                 125             


Cys Gly Gln Val Arg Gly Pro Val Gln Met Ala Phe Ala Arg Ser Val 
    130                 135                 140                 


Glu Pro Val Val Pro Gln Glu Val Ser Ile Thr Arg Met Ala Val Thr 
145                 150                 155                 160 


Thr Lys Ala Glu Ala Glu Lys Gln Gln Gly Asp Asn Arg Thr Met Gly 
                165                 170                 175     


Arg Lys His Ile Val Pro Tyr Gly Leu Tyr Val Ala His Gly Phe Ile 
            180                 185                 190         


Ser Ala Pro Leu Ala Glu Lys Thr Gly Phe Ser Asp Glu Asp Leu Thr 
        195                 200                 205             


Leu Phe Trp Asp Ala Leu Val Asn Met Phe Glu His Asp Arg Ser Ala 
    210                 215                 220                 


Ala Arg Gly Leu Met Ser Ser Arg Lys Leu Ile Val Phe Lys His Gln 
225                 230                 235                 240 


Asn Arg Leu Gly Asn Ala Pro Ala His Lys Leu Phe Asp Leu Val Lys 
                245                 250                 255     


Val Ser Arg Ala Glu Gly Ser Ser Gly Pro Ala Arg Ser Phe Ala Asp 
            260                 265                 270         


Tyr Ala Val Thr Val Gly Gln Ala Pro Glu Gly Val Glu Val Lys Glu 
        275                 280                 285             


Met Leu 
    290 


<210>  272
<211>  97
<212>  DNA
<213>  Desulfovibrio vulgaris


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  CRISPR, Desulfovibrio vulgaris RCH1 plasmid pDEVAL01

<400>  272
gtcgcccccc acgcgggggc gtggattgaa accagtctcg ttaccctgtc gcggagggcg       60

tcgatgtcgc cccccacgcg ggggcgtgga ttgaaac                                97


<210>  273
<211>  711
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(711)
<223>  Cas5

<400>  273
atgcagcgtc gagcgaaagt gcaggtgaag gtgtgggggg aatatgcttg ttttacaaga       60

ccagaattta aagtcgagcg catcagttat cctgtgatga cgccgagcgc agcgcggggg      120

gtattggaag cgatcttttg gaagcccgaa tttcgctacg aggttcgaca aatcgggatt      180

ttaagtttag gggggcaaca agcgattttg cgcaacgaac tcacaagcaa gcaaaataaa      240

aacccgatcg tgattgaaag cgccagggct caacgaacga gcttgatttt aaagaacgtg      300

gcgtattgga tagttgccga tatcatttta acaaatcgag cggttgatcc agcggccaaa      360

taccgggatc agtttaaccg acgagttgaa cgaggtcagt gtcatcatac gccatattta      420

ggaacaaggg agtttgccgc ctacttttca tctatagatg aagatgatgt tgtgaagccg      480

gtcgatatgg acattggcac aatgctgttg gattttgctt ttattgaaga cggttcgaga      540

aaagaaatgg agtttctccg ttatgaagaa acggggacgc gaacggcggt tggattcgcg      600

aagccactct tttttgaggc aaaggtagaa aacggttggc tgcatgttcc aaaagaaaca      660

tatcagcagc tgtatgcatt ggagggacaa aatgctttac gagttgattg a               711


<210>  274
<211>  1776
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(1776)
<223>  Cas8

<400>  274
atgcattgga gggacaaaat gctttacgag ttgattgagt tggcggctaa gttgcagagg       60

gaaaaaaaac taccaccgat ctcctataaa cctaaatcaa tcaattggat tattgattta      120

ggtggggatc aaccatattt gaaagggccg tttagaaggg gagaataccg tttggtggaa      180

gcgccgtttc ggttgaggca agggaaagtt acggaagaaa acgtaaagcc ttatttgttg      240

gctgatgatg gccgctatgt acttggcatc cctgaaagtc cagaaaaggc ggatgaagcg      300

gagttaatgc ataaagggta tgttcgatta attgaggaag cttatgagaa aacaaagttg      360

aaagaattaa aaaaagtgct ggattttttg tacagtccga tgaagaatgc gttccgtgag      420

caaattggtg ccaaggatat cgtgacgttt caagatgatg aggagtcatt gatttttgaa      480

aagagtgaaa ttcaaacatt ttgggctgaa tacttggcga gtgatttgct gtccgacgat      540

gaatgtgact gttctgtttg cgggaagcga tcggcttatg tacggtattt gcccaaccct      600

gtccagttat ttggacaatc gtgccaactg acgtcgttta ataacccgtc gtttgaatca      660

atgggcaaaa ctcaaacgaa taatgtacct gtctgcttcg ggtgtgctac tttggttgtc      720

gatacattga attatctcat tagggaagat caacatcata ctcccctgta tataagcgac      780

cgaaatattt tgcaatccca aatggccata tattgggttg atgaccaaat tgaggggagg      840

ggatgtatcc aacttgatga aaaattgttt gcatcgccaa tcgaacaatg gctttttgat      900

gaagatacaa atcaacggac tcctccccct gagttgaagc agctcgagga actgctggct      960

cttccgaaaa cagggcgcga gcaggcattg cacttagaca agacgttttt tcatatggct     1020

gtcctttcgg ccaataaagc gagattagtc gttcgtgaat ggattcatac gtcgatttct     1080

caattgctga tgcatttgga gaggtatgcg gccgctgtgc gcatcgttca gccgactggg     1140

gaaaaaggct atttattgcc gctggcagct ttgattcgcg ctgttgatat gtcgccgggg     1200

ctggtgcgcc aatgtttgcg cacgatttat caaggggctt tgccgcctac tgaattgctg     1260

ccgttagcgc ttcaacgttt ccgctctttg aaagtattga gtgatccgaa ggaaacgtgg     1320

agatatcatt catcagccag cttgttaaaa ctcgttctca catatggaaa ggaggaagca     1380

aatacaatgc aatcgttaaa caaccattgc ttgcagccgg cttatatttg tggacgatta     1440

ttggccgtat tggaagaaat tcaacggcgc gctttgggat accgaattgg aagcacaatc     1500

gtggatcgat tttatggcgc ggcttctaca gctccagcat cgacatttgg ttcattgctg     1560

aggctttcaa caacagctca tctgccaaaa gtgtctggtg agcttggccg tttgcttgag     1620

gaagtgatga aacagctgga tgaagctgga ggtttcccga cgattttcaa tttaagagaa     1680

caggcagagt tcgcacttgg tttttatcat caacgcgctg agttccgcag tcgccatcaa     1740

agcaatcaaa caaatggaac gggggaaagc caatga                               1776


<210>  275
<211>  1116
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(1116)
<223>  Cas7

<400>  275
atgatggagc gctatatcga tccgacaaaa cgtcatgaat ttgtgttgct ttttgatgtc       60

aaagatggga atccaaatgg ggatccagat gcgggcaaca tgccgcgtgt cgatccggaa      120

acgatgcacg gcattgtgac cgacgttgcg atcaagcgga aaattcgcga ttacgccgcg      180

atggtattag gcaaaccgat ttttattcaa agccaaacgg ctttaaacac catcattttt      240

caagcatatc aagacgtcgg agtgaaactg gcgacgattg agctgaatga agaagaaaaa      300

gaaaatgggg aattgatgaa ttggctttca cagcttgagg aacaaggatt ggtgctcgaa      360

gacaatcggg tgatctatac tggtgaggac atcaaggaga aggatattcg tgaaaaatta      420

acggaaggat tagaagaagc tggtcttaaa aaacaactgg aaaagtcatt gcgaaatatg      480

gcgaaacgtc tggcacaggc ggcaaataat atgaaaattg atgaacaaac acgccaaaat      540

gcgcaaaagg ctttatgcca aaagtactat gatgtccgca tgttcggggc tgtgatgtca      600

acaggattga atgctggtca agtgcgtggg ccgatgcagc tgacattttc tcgctcaatt      660

gacccggtat ttccatggga tttgaccatc acacgctccg cgatcaccaa agaatcggat      720

cgccgcagaa aacaaacgga aatgggaaga aaaccgttaa ttccatacgg attgtatcga      780

ttgcatggat tctacaatcc atttttagga gaaaaaacag gggttacggc agaagattta      840

gctgattttt gggatgcgct cgttcattta tttgcatttg accattctgc ggctcgagga      900

gaaatgaatg tcagagcact ctatattttt agccatgaaa atgcgaaagg atcagcgcca      960

gctcacaagc tgtttgactt ggtgaaaatc gagcgccgcc aacaggaagc tccaaggtca     1020

ttccatgact atgttttgct tggaccggca gatgaggggc agaaagacgt ttttcttgaa     1080

gggttttctg gggtcaccgt gacgcgcctc gtataa                               1116


<210>  276
<211>  711
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(711)
<223>  Cas5

<400>  276
atgcagagaa gggccaaggt gcaggtgaaa gtgtggggcg agtacgcctg ttttacacgc       60

ccagagttca aggtggagcg gatcagctat ccagtgatga ccccatccgc cgcaaggggc      120

gtgctggagg ccatcttttg gaagcccgag ttcagatacg aggtgaggca gatcggcatc      180

ctgagcctgg gaggacagca ggcaatcctg cggaacgagc tgacatccaa gcagaacaag      240

aatcctatcg tgatcgagtc tgccagggca cagcggacca gcctgatcct gaagaacgtg      300

gcctactgga tcgtggccga tatcatcctg acaaataggg cagtggaccc cgcagccaag      360

tatagagacc agttcaatcg ccgggtggag aggggacagt gccaccacac accttacctg      420

ggcacccgcg agtttgccgc ctatttcagc tccatcgacg aggacgatgt ggtgaagcca      480

gtggacatgg atatcggcac catgctgctg gatttcgcct ttatcgagga cggcagcaga      540

aaggagatgg agtttctgag atacgaggag accggaacac gcaccgcagt gggattcgca      600

aagccactgt tctttgaggc caaggtggag aacggctggc tgcacgtgcc caaggagacc      660

taccagcagc tgtatgccct ggagggccag aatgccctga gggtggatta a               711


<210>  277
<211>  1776
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(1776)
<223>  Cas8

<400>  277
atgcactgga gagataagat gctgtatgag ctgatcgagc tggccgccaa gctgcagagg       60

gagaagaagc tgcctccaat cagctacaag cccaagtcca tcaactggat catcgatctg      120

ggaggcgacc agccttacct gaagggacca tttcgccggg gagagtatag gctggtggag      180

gcacctttcc gcctgaggca gggcaaggtg accgaggaga atgtgaagcc atacctgctg      240

gccgacgatg gcagatatgt gctgggcatc ccagagtccc ccgagaaggc agacgaggca      300

gagctgatgc acaagggcta cgtgaggctg atcgaggagg cctatgagaa gacaaagctg      360

aaggagctga agaaggtgct ggattttctg tattctccta tgaagaacgc cttccgggag      420

cagatcggcg ccaaggacat cgtgacattc caggacgatg aggagagcct gatctttgag      480

aagtccgaga tccagacctt ctgggccgag tacctggcct ccgatctgct gtctgacgat      540

gagtgcgact gtagcgtgtg cggcaagaga agcgcctacg tgaggtatct gccaaatccc      600

gtgcagctgt ttggccagtc ttgtcagctg accagcttta acaatccctc tttcgagagc      660

atgggcaaga cacagaccaa caatgtgccc gtgtgcttcg gctgtgccac actggtggtg      720

gataccctga actacctgat cagagaggac cagcaccaca cacctctgta tatctccgat      780

aggaatatcc tgcagtctca gatggccatc tactgggtgg acgatcagat cgagggcaga      840

ggctgcatcc agctggacga gaagctgttt gcctctccta tcgagcagtg gctgttcgac      900

gaggatacaa accagcgcac cccccctcca gagctgaagc agctggagga gctgctggcc      960

ctgccaaaga caggaaggga gcaggccctg cacctggaca agaccttctt tcacatggcc     1020

gtgctgtccg ccaataaggc aaggctggtg gtgcgggagt ggattcacac ctccatctct     1080

cagctgctga tgcacctgga gcggtacgca gcagccgtgc ggatcgtgca gcctacaggc     1140

gagaagggct atctgctgcc actggccgcc ctgatcaggg cagtggatat gagcccaggc     1200

ctggtgagac agtgtctgag gacaatctat cagggcgccc tgccacctac cgagctgctg     1260

cccctggccc tgcagcggtt cagaagcctg aaggtgctgt ctgaccctaa ggagacctgg     1320

agataccact ctagcgcctc tctgctgaag ctggtgctga catatggcaa ggaggaggcc     1380

aacaccatgc agagcctgaa caatcactgc ctgcagcccg cctacatctg tggcaggctg     1440

ctggccgtgc tggaggagat ccagagaagg gccctgggct accggatcgg ctctaccatc     1500

gtggatcggt tctacggagc agccagcaca gcacctgcca gcaccttcgg ctccctgctg     1560

aggctgagca ccacagcaca cctgccaaag gtgtccggcg agctgggccg gctgctggag     1620

gaagtgatga agcagctgga cgaggcagga ggatttccaa caatcttcaa tctgagggag     1680

caggcagagt ttgcactggg cttctaccac cagagggcag agttccgctc tcggcaccag     1740

agcaaccaga caaatggcac cggcgagtcc cagtaa                               1776


<210>  278
<211>  1116
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(1116)
<223>  Cas7

<400>  278
atgatggaga gatatatcga tcccaccaag aggcacgagt ttgtgctgct gttcgacgtg       60

aaggatggca accctaatgg cgacccagat gcaggaaaca tgccccgggt ggaccctgag      120

acaatgcacg gcatcgtgac cgatgtggcc atcaagagaa agatcaggga ctatgccgcc      180

atggtgctgg gcaagcctat ctttatccag tctcagacag ccctgaacac catcatcttc      240

caggcctacc aggatgtggg cgtgaagctg gccaccatcg agctgaatga ggaggagaag      300

gagaacggcg agctgatgaa ttggctgagc cagctggagg agcagggact ggtgctggag      360

gacaatagag tgatctacac aggcgaggat atcaaggaga aggacatcag ggagaagctg      420

accgagggcc tggaggaggc aggcctgaag aagcagctgg agaagagcct gcgcaacatg      480

gcaaagcggc tggcccaggc cgccaacaat atgaagatcg atgagcagac ccgccagaat      540

gcccagaagg ccctgtgcca gaagtactat gacgtgcgga tgttcggcgc cgtgatgtcc      600

acaggcctga acgcaggaca ggtgagggga ccaatgcagc tgaccttttc ccgctctatc      660

gatcccgtgt tcccatggga cctgaccatc acaagaagcg ccatcacaaa ggagtccgat      720

cggagaagga agcagaccga gatgggccgc aagcccctga tcccttacgg cctgtatcgg      780

ctgcacggct tttacaatcc cttcctgggc gagaagacag gagtgaccgc agaggacctg      840

gcagattttt gggacgccct ggtgcacctg ttcgcctttg accacagcgc cgcaagggga      900

gagatgaacg tgcgggccct gtatatcttt tcccacgaga atgccaaggg ctctgcccct      960

gcccacaagc tgttcgatct ggtgaagatc gagcgccggc agcaggaggc accaagatcc     1020

ttccacgact acgtgctgct gggaccagca gatgagggac agaaggacgt gtttctggag     1080

ggcttctctg gcgtgaccgt gacacggctg gtgtaa                               1116


<210>  279
<211>  236
<212>  PRT
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(236)
<223>  Cas5

<400>  279

Met Gln Arg Arg Ala Lys Val Gln Val Lys Val Trp Gly Glu Tyr Ala 
1               5                   10                  15      


Cys Phe Thr Arg Pro Glu Phe Lys Val Glu Arg Ile Ser Tyr Pro Val 
            20                  25                  30          


Met Thr Pro Ser Ala Ala Arg Gly Val Leu Glu Ala Ile Phe Trp Lys 
        35                  40                  45              


Pro Glu Phe Arg Tyr Glu Val Arg Gln Ile Gly Ile Leu Ser Leu Gly 
    50                  55                  60                  


Gly Gln Gln Ala Ile Leu Arg Asn Glu Leu Thr Ser Lys Gln Asn Lys 
65                  70                  75                  80  


Asn Pro Ile Val Ile Glu Ser Ala Arg Ala Gln Arg Thr Ser Leu Ile 
                85                  90                  95      


Leu Lys Asn Val Ala Tyr Trp Ile Val Ala Asp Ile Ile Leu Thr Asn 
            100                 105                 110         


Arg Ala Val Asp Pro Ala Ala Lys Tyr Arg Asp Gln Phe Asn Arg Arg 
        115                 120                 125             


Val Glu Arg Gly Gln Cys His His Thr Pro Tyr Leu Gly Thr Arg Glu 
    130                 135                 140                 


Phe Ala Ala Tyr Phe Ser Ser Ile Asp Glu Asp Asp Val Val Lys Pro 
145                 150                 155                 160 


Val Asp Met Asp Ile Gly Thr Met Leu Leu Asp Phe Ala Phe Ile Glu 
                165                 170                 175     


Asp Gly Ser Arg Lys Glu Met Glu Phe Leu Arg Tyr Glu Glu Thr Gly 
            180                 185                 190         


Thr Arg Thr Ala Val Gly Phe Ala Lys Pro Leu Phe Phe Glu Ala Lys 
        195                 200                 205             


Val Glu Asn Gly Trp Leu His Val Pro Lys Glu Thr Tyr Gln Gln Leu 
    210                 215                 220                 


Tyr Ala Leu Glu Gly Gln Asn Ala Leu Arg Val Asp 
225                 230                 235     


<210>  280
<211>  591
<212>  PRT
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(591)
<223>  Cas8

<400>  280

Met His Trp Arg Asp Lys Met Leu Tyr Glu Leu Ile Glu Leu Ala Ala 
1               5                   10                  15      


Lys Leu Gln Arg Glu Lys Lys Leu Pro Pro Ile Ser Tyr Lys Pro Lys 
            20                  25                  30          


Ser Ile Asn Trp Ile Ile Asp Leu Gly Gly Asp Gln Pro Tyr Leu Lys 
        35                  40                  45              


Gly Pro Phe Arg Arg Gly Glu Tyr Arg Leu Val Glu Ala Pro Phe Arg 
    50                  55                  60                  


Leu Arg Gln Gly Lys Val Thr Glu Glu Asn Val Lys Pro Tyr Leu Leu 
65                  70                  75                  80  


Ala Asp Asp Gly Arg Tyr Val Leu Gly Ile Pro Glu Ser Pro Glu Lys 
                85                  90                  95      


Ala Asp Glu Ala Glu Leu Met His Lys Gly Tyr Val Arg Leu Ile Glu 
            100                 105                 110         


Glu Ala Tyr Glu Lys Thr Lys Leu Lys Glu Leu Lys Lys Val Leu Asp 
        115                 120                 125             


Phe Leu Tyr Ser Pro Met Lys Asn Ala Phe Arg Glu Gln Ile Gly Ala 
    130                 135                 140                 


Lys Asp Ile Val Thr Phe Gln Asp Asp Glu Glu Ser Leu Ile Phe Glu 
145                 150                 155                 160 


Lys Ser Glu Ile Gln Thr Phe Trp Ala Glu Tyr Leu Ala Ser Asp Leu 
                165                 170                 175     


Leu Ser Asp Asp Glu Cys Asp Cys Ser Val Cys Gly Lys Arg Ser Ala 
            180                 185                 190         


Tyr Val Arg Tyr Leu Pro Asn Pro Val Gln Leu Phe Gly Gln Ser Cys 
        195                 200                 205             


Gln Leu Thr Ser Phe Asn Asn Pro Ser Phe Glu Ser Met Gly Lys Thr 
    210                 215                 220                 


Gln Thr Asn Asn Val Pro Val Cys Phe Gly Cys Ala Thr Leu Val Val 
225                 230                 235                 240 


Asp Thr Leu Asn Tyr Leu Ile Arg Glu Asp Gln His His Thr Pro Leu 
                245                 250                 255     


Tyr Ile Ser Asp Arg Asn Ile Leu Gln Ser Gln Met Ala Ile Tyr Trp 
            260                 265                 270         


Val Asp Asp Gln Ile Glu Gly Arg Gly Cys Ile Gln Leu Asp Glu Lys 
        275                 280                 285             


Leu Phe Ala Ser Pro Ile Glu Gln Trp Leu Phe Asp Glu Asp Thr Asn 
    290                 295                 300                 


Gln Arg Thr Pro Pro Pro Glu Leu Lys Gln Leu Glu Glu Leu Leu Ala 
305                 310                 315                 320 


Leu Pro Lys Thr Gly Arg Glu Gln Ala Leu His Leu Asp Lys Thr Phe 
                325                 330                 335     


Phe His Met Ala Val Leu Ser Ala Asn Lys Ala Arg Leu Val Val Arg 
            340                 345                 350         


Glu Trp Ile His Thr Ser Ile Ser Gln Leu Leu Met His Leu Glu Arg 
        355                 360                 365             


Tyr Ala Ala Ala Val Arg Ile Val Gln Pro Thr Gly Glu Lys Gly Tyr 
    370                 375                 380                 


Leu Leu Pro Leu Ala Ala Leu Ile Arg Ala Val Asp Met Ser Pro Gly 
385                 390                 395                 400 


Leu Val Arg Gln Cys Leu Arg Thr Ile Tyr Gln Gly Ala Leu Pro Pro 
                405                 410                 415     


Thr Glu Leu Leu Pro Leu Ala Leu Gln Arg Phe Arg Ser Leu Lys Val 
            420                 425                 430         


Leu Ser Asp Pro Lys Glu Thr Trp Arg Tyr His Ser Ser Ala Ser Leu 
        435                 440                 445             


Leu Lys Leu Val Leu Thr Tyr Gly Lys Glu Glu Ala Asn Thr Met Gln 
    450                 455                 460                 


Ser Leu Asn Asn His Cys Leu Gln Pro Ala Tyr Ile Cys Gly Arg Leu 
465                 470                 475                 480 


Leu Ala Val Leu Glu Glu Ile Gln Arg Arg Ala Leu Gly Tyr Arg Ile 
                485                 490                 495     


Gly Ser Thr Ile Val Asp Arg Phe Tyr Gly Ala Ala Ser Thr Ala Pro 
            500                 505                 510         


Ala Ser Thr Phe Gly Ser Leu Leu Arg Leu Ser Thr Thr Ala His Leu 
        515                 520                 525             


Pro Lys Val Ser Gly Glu Leu Gly Arg Leu Leu Glu Glu Val Met Lys 
    530                 535                 540                 


Gln Leu Asp Glu Ala Gly Gly Phe Pro Thr Ile Phe Asn Leu Arg Glu 
545                 550                 555                 560 


Gln Ala Glu Phe Ala Leu Gly Phe Tyr His Gln Arg Ala Glu Phe Arg 
                565                 570                 575     


Ser Arg His Gln Ser Asn Gln Thr Asn Gly Thr Gly Glu Ser Gln 
            580                 585                 590     


<210>  281
<211>  371
<212>  PRT
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(371)
<223>  Cas7

<400>  281

Met Met Glu Arg Tyr Ile Asp Pro Thr Lys Arg His Glu Phe Val Leu 
1               5                   10                  15      


Leu Phe Asp Val Lys Asp Gly Asn Pro Asn Gly Asp Pro Asp Ala Gly 
            20                  25                  30          


Asn Met Pro Arg Val Asp Pro Glu Thr Met His Gly Ile Val Thr Asp 
        35                  40                  45              


Val Ala Ile Lys Arg Lys Ile Arg Asp Tyr Ala Ala Met Val Leu Gly 
    50                  55                  60                  


Lys Pro Ile Phe Ile Gln Ser Gln Thr Ala Leu Asn Thr Ile Ile Phe 
65                  70                  75                  80  


Gln Ala Tyr Gln Asp Val Gly Val Lys Leu Ala Thr Ile Glu Leu Asn 
                85                  90                  95      


Glu Glu Glu Lys Glu Asn Gly Glu Leu Met Asn Trp Leu Ser Gln Leu 
            100                 105                 110         


Glu Glu Gln Gly Leu Val Leu Glu Asp Asn Arg Val Ile Tyr Thr Gly 
        115                 120                 125             


Glu Asp Ile Lys Glu Lys Asp Ile Arg Glu Lys Leu Thr Glu Gly Leu 
    130                 135                 140                 


Glu Glu Ala Gly Leu Lys Lys Gln Leu Glu Lys Ser Leu Arg Asn Met 
145                 150                 155                 160 


Ala Lys Arg Leu Ala Gln Ala Ala Asn Asn Met Lys Ile Asp Glu Gln 
                165                 170                 175     


Thr Arg Gln Asn Ala Gln Lys Ala Leu Cys Gln Lys Tyr Tyr Asp Val 
            180                 185                 190         


Arg Met Phe Gly Ala Val Met Ser Thr Gly Leu Asn Ala Gly Gln Val 
        195                 200                 205             


Arg Gly Pro Met Gln Leu Thr Phe Ser Arg Ser Ile Asp Pro Val Phe 
    210                 215                 220                 


Pro Trp Asp Leu Thr Ile Thr Arg Ser Ala Ile Thr Lys Glu Ser Asp 
225                 230                 235                 240 


Arg Arg Arg Lys Gln Thr Glu Met Gly Arg Lys Pro Leu Ile Pro Tyr 
                245                 250                 255     


Gly Leu Tyr Arg Leu His Gly Phe Tyr Asn Pro Phe Leu Gly Glu Lys 
            260                 265                 270         


Thr Gly Val Thr Ala Glu Asp Leu Ala Asp Phe Trp Asp Ala Leu Val 
        275                 280                 285             


His Leu Phe Ala Phe Asp His Ser Ala Ala Arg Gly Glu Met Asn Val 
    290                 295                 300                 


Arg Ala Leu Tyr Ile Phe Ser His Glu Asn Ala Lys Gly Ser Ala Pro 
305                 310                 315                 320 


Ala His Lys Leu Phe Asp Leu Val Lys Ile Glu Arg Arg Gln Gln Glu 
                325                 330                 335     


Ala Pro Arg Ser Phe His Asp Tyr Val Leu Leu Gly Pro Ala Asp Glu 
            340                 345                 350         


Gly Gln Lys Asp Val Phe Leu Glu Gly Phe Ser Gly Val Thr Val Thr 
        355                 360                 365             


Arg Leu Val 
    370     


<210>  282
<211>  111
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921


<220>
<221>  misc_feature
<222>  (1)..(111)
<223>  CRISPR

<400>  282
gttgcacccg gctattaagc cgggtgagga ttgaaactat atcacacagc ttcttagtat       60

catcgacaac acgtgttgca cccggctatt aagccgggtg aggattgaaa c               111


<210>  283
<211>  1263
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(1263)
<223>  Cas8

<400>  283
gtgatagatc cagtaatagc cgcctttttt gcggaacgta aagaagcatg gctaaagaag       60

aatatcagtg cagcgatgtc tgatgcagaa gtcttggaaa aacaacagga gtgtgagcaa      120

aactttctat tagacaattg gttgcctgat gcggccaaaa gggcggggca aatttcagtg      180

gcttcacatc cttgtacctt tagtcatccg agtgcgcgga aaaacaaaaa tggctacgta      240

tcgtccatta ttgccaagaa caaaccaaga atagatggtt ttcttcgctc tggtaatgtg      300

agtgttgagc cagatgcact tggtaacgca gcagcattag atgtatacaa gtttctcagc      360

ttagagatga gcgaccaacg ttctttattg gtgcatattg aacaagaaag cgagttagca      420

aggcaattgc ttgatatacc aagttgtgaa tatcaggcgc tacgcgatgg ctttttaaaa      480

atggtcgata gcgatcaggc gtctgtttcc agctcgaaga ttaagcaagt ttatttcccg      540

atagccgatg gggaatatca tttattgtcg ttattaaccc attccggcca tctttttgaa      600

ttgcgtaaac gtctagatgc acttcgattt ggtgatgcgg taaaagaggc aagagagtgc      660

aaaaaaacga atcactttca ccccgcgggt taccaagaga tctttggtct caccacgatt      720

gggtttggcg gcacaaaacc gcaaaatatc agcgtgctca ataaccaaaa cgcaggtaaa      780

gcacatttac tagcctctat tccacctgag ttaacacctc gcgatattcg tctgccgaaa      840

acggattttt tcaaagagag ttttaacgct tggcaagcca aagaagtact tgaatcgttg      900

catcgactct ttcaaaccga ctgcaacaac atcaatctcc gtgatggccg tgactaccgc      960

attcagcaat acgtagattt ggtgattgaa aaaatgtggc aagtacgcct gtttcttgaa     1020

gcgtattccg gtgaactatc gagtgcgttg ccgttggagc aaaaaatctg gctctatcca     1080

gagtttgctg agcagcgtca gcaagaggat gagtggctcg ataaaatcat tcgccacatt     1140

gcgcgaggct taatcaacca ttacagccgc agcaaagtga tcactaatcc cgtcacattg     1200

gcagaccaag agctgctggc gatagaagag gtggttgcca gcaataagga gaacttgcga     1260

tga                                                                   1263


<210>  284
<211>  888
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(888)
<223>  Cas5

<400>  284
atgaacgtat tgatcttacc gcatcttaaa attcacaacg ccaatgcact ttcaagcccc       60

tttactgttg gctttcctgc catgacggca tggctaggct ttgtacatgc cttagagcgc      120

aagctcagcc aagcagggtt atccgatctc atgctgcata gtactgctgt agtgagccac      180

cgttgtgatg tacagactca taaaggcgaa ggtgactttg ttcattcaat tatcggtact      240

gccaatccac tcgataagga tggttcacgc tcggcattta tcgaggaagc acgctgtcat      300

ttagatgtgt cccttgtcat tgagtggagt ggcaatgaag agcaagttca acagccagag      360

tttaccgagc agttgcaagc agtgatcgcg acgatgaaag tcgcaggggg cgacgttctt      420

gccgttggga agccctcagt taaatctgtg atcactgagg atgatactgg cagagttctg      480

cgccagttaa tgcctggtta tgtgctgatc gaacgccgcg atttaatgat tgacgccatg      540

cagcaaggtg atgacgcaat agatgcgctg ctgggttacc tcacagtgca ccaccattgt      600

gagcagcttg aagaccaaag tgttgtttgg catagccagc gcaaaacgag tggctggatt      660

gtgccgattg ccactggttt tcaaggtatt tcaccgttag gtgaggcaaa aaatcagcgc      720

gatccatcag tgccgcatcg ctttgctgaa agtgtggtca cgctgggtga atttgtcatg      780

gtgcacaaaa tcaaacatct cgatgacatc ctttggcaat accacccgga tttagaaaac      840

gatctttacc tttgtcagaa agttaacgct atcaacgaac atcaataa                   888


<210>  285
<211>  1032
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(1032)
<223>  Cas7

<400>  285
atggctaaaa ataacgacat cgcatcagta ctcgcatttg aaaaaaaact agtcccatcg       60

gatggctacc tctttggatg tcagtgggaa accaaagagc aagcaacccc attaaccctg      120

caagagaaat cagtacgtgg cactatctcc aaccgtttaa aagccgcagt acaaaatgat      180

cccgctaagc ttaatgcgga agttgaaaaa gcaaacttgc agcgagtgga tgcctgtgcg      240

ttggggcagg atcacgatac tttgaagcta catttcacac tcaaagtatt agggggactt      300

gcccaacctt cggcgtgtaa caatgcgctg ttcaaacaga gctacagtac tgcggtttcg      360

cagtacatta ccaaatatgg ctgtttcgaa ttggcgaaac gttatgccac caaccttgcc      420

aatgcccgtt ttctatggcg caaccgcgtt ggcgcagaag agattgaagt gcaagtcaaa      480

gcattaaaca aaggggctga gcagacttgg acttttaatg ccaaacaatt cagtactcgc      540

cactttgatc ataacgactc acagctcaat agtctggccg acagaattgc tcaggcactg      600

gccagcgaaa cagatcattt gatgttgcaa attgactgct atgccaaagt cggtaaagcc      660

caagaagttt accccagtga agagttagtg ctcgataagg gcaacagcaa aaccaagaaa      720

agtaaaatcc tgtatgcagt taatgagcat gctgcgatgc attcacaaaa aattggtaac      780

gcactgcgtt ccattgatac ttggtaccca gattacgcat ctgaggagca aagtgcagga      840

gccattgcga ttgaacccta tggcgctgtt accaatttag gaaaggcgtt ccgcacaccg      900

aaagataagc aagattttta cactttcttt gataaatggg cgcgtggtga aagtttgccc      960

cgtgaagaag atgagcatta cgtcatggcg gtattggtgc gtggtggtgt atttggcgaa     1020

agtgacaaat ag                                                         1032


<210>  286
<211>  639
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(639)
<223>  Cas6

<400>  286
atgaactact accaagagat cacgttattg ccagatgccg acattgcctt gggctttctt       60

tggcaaaacg tctttcaaca agtgcacatt gctttagtgg agcacaaagt ggcgagcaac      120

caatctctgg ttgcggtcgg ttttcctgat tatcgccaag caaagtttcc gctcggcgca      180

aagctgcgtc tctttgcaaa agagcaagta acactggaaa agttggatat ccaccgctgg      240

ctaactcggc tagaagacta tgtgcacatc aaaggggtca aacccgtacc aagcgatgta      300

acttatgtaa gctttgtacg caagcaggtg aaatcgcccg aacgaataga gcgggatatg      360

cagcaaaaag ccgaactatg ggcagcaaaa tctggtaaac cgctggtgga atgtttagtg      420

gatttacaac aaagcaagcc gacagcgttg tgctccttgc cctttattta cttgcatagc      480

cagcaaacca agcaacgttc accagaaaaa aacagcaagt tcccgctgtt tattgagatg      540

cagcagcaaa gcacatctca agatgggggc ttcgattgct atggtttgag tagcaaagcg      600

aatgggcagt caatgttggc tactgtaccg cacttttaa                             639


<210>  287
<211>  1263
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(1263)
<223>  Cas8

<400>  287
atgatcgacc cagtgatcgc cgccttcttt gccgagagga aggaggcctg gctgaagaag       60

aatatcagcg ccgcaatgtc cgatgcagag gtgctggaga agcagcagga gtgcgagcag      120

aacttcctgc tggacaattg gctgcccgat gcagcaaaga gggcaggaca gatctctgtg      180

gccagccacc catgtacatt ttcccacccc tctgcccgca agaacaagaa tggctacgtg      240

tcctctatca tcgccaagaa caagccacgc atcgacggct tcctgcggtc tggcaacgtg      300

agcgtggagc cagacgccct gggaaatgca gccgccctgg acgtgtacaa gtttctgtcc      360

ctggagatgt ctgatcagcg cagcctgctg gtgcacatcg agcaggagag cgagctggcc      420

aggcagctgc tggacatccc ttcctgcgag tatcaggccc tgagagatgg cttcctgaag      480

atggtggact ccgatcaggc ctctgtgagc tcctctaaga tcaagcaggt gtactttcca      540

atcgccgacg gcgagtatca cctgctgtcc ctgctgaccc actctggcca cctgttcgag      600

ctgaggaagc gcctggacgc cctgaggttt ggcgatgccg tgaaggaggc ccgggagtgt      660

aagaagacca accacttcca cccagccggc taccaggaga tcttcggcct gaccacaatc      720

ggctttggcg gcacaaagcc ccagaacatc agcgtgctga acaatcagaa tgcaggcaag      780

gcacacctgc tggcctccat cccccctgag ctgacccctc gggacatcag actgccaaag      840

acagatttct ttaaggagtc cttcaacgcc tggcaggcca aggaggtgct ggagtctctg      900

cacagactgt ttcagaccga ctgcaacaat atcaatctga gggacggccg cgattacaga      960

atccagcagt atgtggacct ggtcatcgag aagatgtggc aggtgaggct gttcctggag     1020

gcctacagcg gcgagctgag ctccgccctg cctctggagc agaagatctg gctgtatcca     1080

gagtttgcag agcagaggca gcaggaggac gagtggctgg ataagatcat ccgccacatc     1140

gcccggggcc tgatcaacca ctacagccgg tccaaagtga tcaccaatcc tgtgacactg     1200

gccgaccagg agctgctggc catcgaggag gtggtggcct ccaacaagga gaatctgaga     1260

taa                                                                   1263


<210>  288
<211>  888
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(888)
<223>  Cas5

<400>  288
atgaatgtgc tgatcctgcc tcacctgaag atccacaacg ccaatgccct gtctagcccc       60

tttaccgtgg gcttccctgc catgacagca tggctgggat tcgtgcacgc cctggagaga      120

aagctgtccc aggccggcct gtctgatctg atgctgcaca gcaccgcagt ggtgtcccac      180

aggtgcgacg tgcagacaca caagggcgag ggcgatttcg tgcacagcat catcggcacc      240

gccaaccccc tggacaagga tggcagccgc tccgccttta tcgaggaggc ccggtgtcac      300

ctggacgtga gcctggtcat cgagtggtcc ggcaatgagg agcaggtgca gcagcctgag      360

tttaccgagc agctgcaggc cgtgatcgcc acaatgaagg tggcaggagg cgatgtgctg      420

gccgtgggca agccttccgt gaagtctgtg atcaccgagg acgatacagg cagggtgctg      480

aggcagctga tgccaggata cgtgctgatc gagcggagag acctgatgat cgatgccatg      540

cagcagggcg acgatgcaat cgacgccctg ctgggctatc tgaccgtgca ccaccactgc      600

gagcagctgg aggatcagtc tgtggtgtgg cacagccagc ggaagacctc cggctggatc      660

gtgcccatcg ccacaggctt ccagggcatc tcccctctgg gcgaggccaa gaaccagaga      720

gaccctagcg tgccacacag gttcgcagag tccgtggtga ccctgggaga gtttgtgatg      780

gtgcacaaga tcaagcacct ggacgatatc ctgtggcagt accacccaga cctggagaac      840

gatctgtatc tgtgccagaa ggtgaacgcc atcaatgagc accagtaa                   888


<210>  289
<211>  1032
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(1032)
<223>  Cas7

<400>  289
atggccaaga acaatgacat cgcctctgtg ctggccttcg agaagaagct ggtgcctagc       60

gatggctacc tgtttggctg ccagtgggag accaaggagc aggccacccc actgacactg      120

caggagaaga gcgtgagagg cacaatctcc aacaggctga aggccgccgt gcagaacgac      180

cctgccaagc tgaatgccga ggtggagaag gccaatctgc agcgggtgga tgcctgtgca      240

ctgggacagg accacgatac cctgaagctg cacttcacac tgaaggtgct gggaggcctg      300

gcccagccat ctgcctgcaa caatgccctg tttaagcagt cttacagcac cgccgtgagc      360

cagtacatca caaagtatgg ctgtttcgag ctggccaaga gatatgccac caacctggcc      420

aatgccaggt ttctgtggcg gaacagagtg ggcgccgagg agatcgaggt gcaggtgaag      480

gccctgaaca agggcgccga gcagacctgg accttcaacg ccaagcagtt ctctaccagg      540

cactttgacc acaacgatag ccagctgaat tccctggccg acaggatcgc acaggccctg      600

gccagcgaga cagaccacct gatgctgcag atcgattgct acgccaaagt gggcaaggcc      660

caggaggtgt atccctccga ggagctggtg ctggataagg gcaacagcaa gaccaagaag      720

tccaagatcc tgtacgccgt gaacgagcac gccgccatgc actctcagaa gatcggcaat      780

gccctgcgca gcatcgacac atggtaccct gattatgcct ctgaggagca gagcgccgga      840

gcaatcgcaa tcgagcccta cggcgccgtg accaatctgg gcaaggcctt cagaacccct      900

aaggacaagc aggacttcta caccttcttt gacaagtggg caaggggaga gagcctgcct      960

agggaggagg atgagcacta cgtgatggcc gtgctggtgc ggggaggcgt gttcggagag     1020

tccgacaagt aa                                                         1032


<210>  290
<211>  639
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(639)
<223>  Cas6

<400>  290
atgaattact atcaggagat cacactgctg cccgacgcag atatcgccct gggcttcctg       60

tggcagaacg tgtttcagca ggtgcacatc gccctggtgg agcacaaggt ggcctctaat      120

cagagcctgg tggccgtggg cttccctgac tacagacagg ccaagtttcc actgggcgcc      180

aagctgaggc tgttcgccaa ggagcaggtg accctggaga agctggacat ccacagatgg      240

ctgacaaggc tggaggatta cgtgcacatc aagggcgtga agccagtgcc ctctgacgtg      300

acctatgtga gctttgtgag aaagcaggtg aagtcccccg agcggatcga gagagatatg      360

cagcagaagg ccgagctgtg ggccgccaag tctggcaagc ctctggtgga gtgcctggtg      420

gacctgcagc agtccaagcc caccgccctg tgctctctgc ctttcatcta cctgcacagc      480

cagcagacaa agcagaggtc tccagagaag aacagcaagt ttcccctgtt catcgagatg      540

cagcagcagt ccacatctca ggacggcggc ttcgattgct atggcctgag ctccaaggcc      600

aatggccaga gcatgctggc caccgtgcca cacttttaa                             639


<210>  291
<211>  420
<212>  PRT
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(420)
<223>  Cas8

<400>  291

Met Ile Asp Pro Val Ile Ala Ala Phe Phe Ala Glu Arg Lys Glu Ala 
1               5                   10                  15      


Trp Leu Lys Lys Asn Ile Ser Ala Ala Met Ser Asp Ala Glu Val Leu 
            20                  25                  30          


Glu Lys Gln Gln Glu Cys Glu Gln Asn Phe Leu Leu Asp Asn Trp Leu 
        35                  40                  45              


Pro Asp Ala Ala Lys Arg Ala Gly Gln Ile Ser Val Ala Ser His Pro 
    50                  55                  60                  


Cys Thr Phe Ser His Pro Ser Ala Arg Lys Asn Lys Asn Gly Tyr Val 
65                  70                  75                  80  


Ser Ser Ile Ile Ala Lys Asn Lys Pro Arg Ile Asp Gly Phe Leu Arg 
                85                  90                  95      


Ser Gly Asn Val Ser Val Glu Pro Asp Ala Leu Gly Asn Ala Ala Ala 
            100                 105                 110         


Leu Asp Val Tyr Lys Phe Leu Ser Leu Glu Met Ser Asp Gln Arg Ser 
        115                 120                 125             


Leu Leu Val His Ile Glu Gln Glu Ser Glu Leu Ala Arg Gln Leu Leu 
    130                 135                 140                 


Asp Ile Pro Ser Cys Glu Tyr Gln Ala Leu Arg Asp Gly Phe Leu Lys 
145                 150                 155                 160 


Met Val Asp Ser Asp Gln Ala Ser Val Ser Ser Ser Lys Ile Lys Gln 
                165                 170                 175     


Val Tyr Phe Pro Ile Ala Asp Gly Glu Tyr His Leu Leu Ser Leu Leu 
            180                 185                 190         


Thr His Ser Gly His Leu Phe Glu Leu Arg Lys Arg Leu Asp Ala Leu 
        195                 200                 205             


Arg Phe Gly Asp Ala Val Lys Glu Ala Arg Glu Cys Lys Lys Thr Asn 
    210                 215                 220                 


His Phe His Pro Ala Gly Tyr Gln Glu Ile Phe Gly Leu Thr Thr Ile 
225                 230                 235                 240 


Gly Phe Gly Gly Thr Lys Pro Gln Asn Ile Ser Val Leu Asn Asn Gln 
                245                 250                 255     


Asn Ala Gly Lys Ala His Leu Leu Ala Ser Ile Pro Pro Glu Leu Thr 
            260                 265                 270         


Pro Arg Asp Ile Arg Leu Pro Lys Thr Asp Phe Phe Lys Glu Ser Phe 
        275                 280                 285             


Asn Ala Trp Gln Ala Lys Glu Val Leu Glu Ser Leu His Arg Leu Phe 
    290                 295                 300                 


Gln Thr Asp Cys Asn Asn Ile Asn Leu Arg Asp Gly Arg Asp Tyr Arg 
305                 310                 315                 320 


Ile Gln Gln Tyr Val Asp Leu Val Ile Glu Lys Met Trp Gln Val Arg 
                325                 330                 335     


Leu Phe Leu Glu Ala Tyr Ser Gly Glu Leu Ser Ser Ala Leu Pro Leu 
            340                 345                 350         


Glu Gln Lys Ile Trp Leu Tyr Pro Glu Phe Ala Glu Gln Arg Gln Gln 
        355                 360                 365             


Glu Asp Glu Trp Leu Asp Lys Ile Ile Arg His Ile Ala Arg Gly Leu 
    370                 375                 380                 


Ile Asn His Tyr Ser Arg Ser Lys Val Ile Thr Asn Pro Val Thr Leu 
385                 390                 395                 400 


Ala Asp Gln Glu Leu Leu Ala Ile Glu Glu Val Val Ala Ser Asn Lys 
                405                 410                 415     


Glu Asn Leu Arg 
            420 


<210>  292
<211>  295
<212>  PRT
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(295)
<223>  Cas5

<400>  292

Met Asn Val Leu Ile Leu Pro His Leu Lys Ile His Asn Ala Asn Ala 
1               5                   10                  15      


Leu Ser Ser Pro Phe Thr Val Gly Phe Pro Ala Met Thr Ala Trp Leu 
            20                  25                  30          


Gly Phe Val His Ala Leu Glu Arg Lys Leu Ser Gln Ala Gly Leu Ser 
        35                  40                  45              


Asp Leu Met Leu His Ser Thr Ala Val Val Ser His Arg Cys Asp Val 
    50                  55                  60                  


Gln Thr His Lys Gly Glu Gly Asp Phe Val His Ser Ile Ile Gly Thr 
65                  70                  75                  80  


Ala Asn Pro Leu Asp Lys Asp Gly Ser Arg Ser Ala Phe Ile Glu Glu 
                85                  90                  95      


Ala Arg Cys His Leu Asp Val Ser Leu Val Ile Glu Trp Ser Gly Asn 
            100                 105                 110         


Glu Glu Gln Val Gln Gln Pro Glu Phe Thr Glu Gln Leu Gln Ala Val 
        115                 120                 125             


Ile Ala Thr Met Lys Val Ala Gly Gly Asp Val Leu Ala Val Gly Lys 
    130                 135                 140                 


Pro Ser Val Lys Ser Val Ile Thr Glu Asp Asp Thr Gly Arg Val Leu 
145                 150                 155                 160 


Arg Gln Leu Met Pro Gly Tyr Val Leu Ile Glu Arg Arg Asp Leu Met 
                165                 170                 175     


Ile Asp Ala Met Gln Gln Gly Asp Asp Ala Ile Asp Ala Leu Leu Gly 
            180                 185                 190         


Tyr Leu Thr Val His His His Cys Glu Gln Leu Glu Asp Gln Ser Val 
        195                 200                 205             


Val Trp His Ser Gln Arg Lys Thr Ser Gly Trp Ile Val Pro Ile Ala 
    210                 215                 220                 


Thr Gly Phe Gln Gly Ile Ser Pro Leu Gly Glu Ala Lys Asn Gln Arg 
225                 230                 235                 240 


Asp Pro Ser Val Pro His Arg Phe Ala Glu Ser Val Val Thr Leu Gly 
                245                 250                 255     


Glu Phe Val Met Val His Lys Ile Lys His Leu Asp Asp Ile Leu Trp 
            260                 265                 270         


Gln Tyr His Pro Asp Leu Glu Asn Asp Leu Tyr Leu Cys Gln Lys Val 
        275                 280                 285             


Asn Ala Ile Asn Glu His Gln 
    290                 295 


<210>  293
<211>  343
<212>  PRT
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(343)
<223>  Cas7

<400>  293

Met Ala Lys Asn Asn Asp Ile Ala Ser Val Leu Ala Phe Glu Lys Lys 
1               5                   10                  15      


Leu Val Pro Ser Asp Gly Tyr Leu Phe Gly Cys Gln Trp Glu Thr Lys 
            20                  25                  30          


Glu Gln Ala Thr Pro Leu Thr Leu Gln Glu Lys Ser Val Arg Gly Thr 
        35                  40                  45              


Ile Ser Asn Arg Leu Lys Ala Ala Val Gln Asn Asp Pro Ala Lys Leu 
    50                  55                  60                  


Asn Ala Glu Val Glu Lys Ala Asn Leu Gln Arg Val Asp Ala Cys Ala 
65                  70                  75                  80  


Leu Gly Gln Asp His Asp Thr Leu Lys Leu His Phe Thr Leu Lys Val 
                85                  90                  95      


Leu Gly Gly Leu Ala Gln Pro Ser Ala Cys Asn Asn Ala Leu Phe Lys 
            100                 105                 110         


Gln Ser Tyr Ser Thr Ala Val Ser Gln Tyr Ile Thr Lys Tyr Gly Cys 
        115                 120                 125             


Phe Glu Leu Ala Lys Arg Tyr Ala Thr Asn Leu Ala Asn Ala Arg Phe 
    130                 135                 140                 


Leu Trp Arg Asn Arg Val Gly Ala Glu Glu Ile Glu Val Gln Val Lys 
145                 150                 155                 160 


Ala Leu Asn Lys Gly Ala Glu Gln Thr Trp Thr Phe Asn Ala Lys Gln 
                165                 170                 175     


Phe Ser Thr Arg His Phe Asp His Asn Asp Ser Gln Leu Asn Ser Leu 
            180                 185                 190         


Ala Asp Arg Ile Ala Gln Ala Leu Ala Ser Glu Thr Asp His Leu Met 
        195                 200                 205             


Leu Gln Ile Asp Cys Tyr Ala Lys Val Gly Lys Ala Gln Glu Val Tyr 
    210                 215                 220                 


Pro Ser Glu Glu Leu Val Leu Asp Lys Gly Asn Ser Lys Thr Lys Lys 
225                 230                 235                 240 


Ser Lys Ile Leu Tyr Ala Val Asn Glu His Ala Ala Met His Ser Gln 
                245                 250                 255     


Lys Ile Gly Asn Ala Leu Arg Ser Ile Asp Thr Trp Tyr Pro Asp Tyr 
            260                 265                 270         


Ala Ser Glu Glu Gln Ser Ala Gly Ala Ile Ala Ile Glu Pro Tyr Gly 
        275                 280                 285             


Ala Val Thr Asn Leu Gly Lys Ala Phe Arg Thr Pro Lys Asp Lys Gln 
    290                 295                 300                 


Asp Phe Tyr Thr Phe Phe Asp Lys Trp Ala Arg Gly Glu Ser Leu Pro 
305                 310                 315                 320 


Arg Glu Glu Asp Glu His Tyr Val Met Ala Val Leu Val Arg Gly Gly 
                325                 330                 335     


Val Phe Gly Glu Ser Asp Lys 
            340             


<210>  294
<211>  212
<212>  PRT
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(212)
<223>  Cas6

<400>  294

Met Asn Tyr Tyr Gln Glu Ile Thr Leu Leu Pro Asp Ala Asp Ile Ala 
1               5                   10                  15      


Leu Gly Phe Leu Trp Gln Asn Val Phe Gln Gln Val His Ile Ala Leu 
            20                  25                  30          


Val Glu His Lys Val Ala Ser Asn Gln Ser Leu Val Ala Val Gly Phe 
        35                  40                  45              


Pro Asp Tyr Arg Gln Ala Lys Phe Pro Leu Gly Ala Lys Leu Arg Leu 
    50                  55                  60                  


Phe Ala Lys Glu Gln Val Thr Leu Glu Lys Leu Asp Ile His Arg Trp 
65                  70                  75                  80  


Leu Thr Arg Leu Glu Asp Tyr Val His Ile Lys Gly Val Lys Pro Val 
                85                  90                  95      


Pro Ser Asp Val Thr Tyr Val Ser Phe Val Arg Lys Gln Val Lys Ser 
            100                 105                 110         


Pro Glu Arg Ile Glu Arg Asp Met Gln Gln Lys Ala Glu Leu Trp Ala 
        115                 120                 125             


Ala Lys Ser Gly Lys Pro Leu Val Glu Cys Leu Val Asp Leu Gln Gln 
    130                 135                 140                 


Ser Lys Pro Thr Ala Leu Cys Ser Leu Pro Phe Ile Tyr Leu His Ser 
145                 150                 155                 160 


Gln Gln Thr Lys Gln Arg Ser Pro Glu Lys Asn Ser Lys Phe Pro Leu 
                165                 170                 175     


Phe Ile Glu Met Gln Gln Gln Ser Thr Ser Gln Asp Gly Gly Phe Asp 
            180                 185                 190         


Cys Tyr Gly Leu Ser Ser Lys Ala Asn Gly Gln Ser Met Leu Ala Thr 
        195                 200                 205             


Val Pro His Phe 
    210         


<210>  295
<211>  88
<212>  DNA
<213>  Vibrio cholerae strain L15


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  CRISPR

<400>  295
gttcactgcc gtacaggcag cttagaaaaa tatgcagggg tttgaaacgc tcgatgttat       60

gttcactgcc gtacaggcag cttagaaa                                          88


<210>  296
<211>  1314
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(1314)
<223>  Cas8

<400>  296
atgacaaccg aagcactgac tcacttcatc atcgactaca tcgcttcacg aaagcagccc       60

aaattagacg cctttgaaaa agaggcggcg aaacggttgg ctcaaggcga ggatgctggc      120

gctatcgcgc aggagcgtca ggagcttgaa gtgaagtatc agccgcgcaa ctggctgacg      180

gatgcggcaa gacgtgctgg gcaaatcagc cttgtcactc atgcggcgaa gtttacccac      240

ggtgactcaa aaagcagcag catttaccgc gaaacggtgg gcgatgaggg ctatttaagt      300

acagctgtgc tggctaacgt ggcggcggat gcggtgggca acgcggctgc tctggacgtg      360

gcaaaactgc tgcaaaccga agtgggcggc gattcgctgc tggcctgcct gaaacgcggc      420

gatcgtagtc cgctgatggg ctttgctgaa aacgacgccc agctggcact gtggatggaa      480

ggattctctc aggcgttaac gcctgctcaa cccacctcgc ataagcttgc caaacagatt      540

tactttccag tcgatggcgg ctatcacctg ctatctccgc tatttgcctc ctcgctggcg      600

caggcgatgc atgaaaaaat ggtggcagca cgatttggcg aacaagcaaa agccgcgcgt      660

gaagctcgcc gggcgggtaa atggcatgcg cagcccgatg tgcgctatcc gaatgttgcc      720

gaaatgcatt ttggcggcac taaaccgcag aatatttcgg cgttaaacag ctcgcgcggt      780

gggcgggtct ggctgctgcc gtcgcagccg ccaaaatgga caatgctcga taaggcgccg      840

caaaatctga ctagtctctt tgcactacgc ggcgatttta accgagcggc aaccgacact      900

gtttcccgga tggtttctct acttaaagag aagactgata acaataatcg ccatatccgc      960

aacgctcggg cgggttatgt tgatgaactg attgatttgt tatttcttca tgcagcgacg     1020

taccagcagg aagcgtggca gggatggacg cttaacagcc cggatttacc tctccaccag     1080

cagctttggc tcgatccctg gcgtagcaaa acagacgaga cattccgctc tgagcgtgaa     1140

aaaggcgact ggcaacgaag cgtcgcggat gacttcgcgc gctggctgaa ctatcgcctg     1200

aataaagcgc gtctcgatgt ggggatcgcc gagcgccgtg agtggcaaac tcagcgtctg     1260

tttagtcaac ggatgcggga aatggaagct attgtgcagg aggcgctgaa atga           1314


<210>  297
<211>  936
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(936)
<223>  Cas5

<400>  297
atgagctatc tgcttttatt gccccatatt cgcatcgaaa acgcaaatgc ggtggcagga       60

ttaacctggg gattccccgc tattacccac tttttagggt atgttcatgc gctttcccgc      120

agggtgagcg aatttggcgt ctctttcacc ggctgcgcgg tgattaatca tgaacaccat      180

attcaggcct attcctccgg gcgcgactat caatttgcgc tgactcgtaa tccgctgacc      240

aaagaaggta aaaccgctgc ctttaacgaa gaggggcgaa tgcatcttac cgtctctttg      300

cttgttgaat gccagggcga aatcatcaat ggcgaatatg gcaaagcggc gctctgttcg      360

tctctgctta cgctctgcca gagccacaaa ctggcgggcg gaagtatcgt gatgatgcgt      420

gagccacaga tatttaatgc gcctgatgat gaaagaacgc tgcgtaagat cctctggcgt      480

ctgatgccgg gttttgcact ctgcgatcgc agcgagtggt tgatggagca ctatcgccag      540

ctgcagcagc ggaggccgga aagcagctta ctggatgcgt ggcttgactt cgcggcgatc      600

aaatatcagc ccgttcagca ggaaccggag gatagcatga gctgggagta tcagccgaaa      660

ccgaagccgg ggtatctggt gccgctgatg tgcggatatc aacgtatttc ccgactatac      720

cagccgggag aagtggccaa cgttcgcgat accacaacgc cgttcgcctt taccgaggcc      780

gtttatggcg ttggagaatg gcgtgggtta catcgtatag ctgaccttga gccgcttatc      840

tggcgctacc gcacgagcga tacaggctac tactgttctg caatgcctgt tgctgatgat      900

gattttatat ttaacgaaga tgacgattta gaataa                                936


<210>  298
<211>  1002
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(1002)
<223>  Cas7

<400>  298
atggcaaagg ctcctgtatc tgtaaaaacg gcttccgtac tggcatttga acgcaagctc       60

gccacctccg atgcgatgat gtatgcgggg aactggctgg gcgatagctg gcaaccgatc      120

gaaattaagg aaaaagcggt acgtggaact atctcgaacc ggcttaaaaa tgccatcgcc      180

agcgatgcaa caaagctgga tgccgagatc caaaaagcga atctgcaacg agtggatacg      240

gcggcgttgc ccgctgatgc cgacacctta aaagtcgtat tcaccctgcg ggtgctgggg      300

aacttagcga cgccatcggt ctgtaatgat atggcctatc agaatgcgat tcagcagacg      360

atcgaaggtt atatcagcga gcacggtttt gccgaactgg ctcgtcgcta tgcggctaac      420

ctcgcaaatg ggcgttttct atggcgcaac cgcattggcg ctgagcagat tcaggttagc      480

gtgagcgcgc aggggcaggc gtgggtattc aatggccacg attattcatt acgtgaattc      540

tctcaggacg atgaggaaat agcctccctt gcggcgctga tcgaacaggg gctaagtggc      600

caggcgtggg tgatgctaac ggttgaggcg caggtacgtt tgggcgccgg gcaggaggtc      660

tttccgtcac aggagctggt actggatagc aacagtagta aaagtcgcgt gctgtatcag      720

gtcgcgggca tcgccgggat ccactcgcag aagatcggca atgcgctgcg cactatcgat      780

acctggcatc caaaagttga tgagctgggg gcgattgcgg tagagccgta cggctcggta      840

accagccgcg gtatggcctg tcgtcagccg aaggacaaga tggattttta taccctgctg      900

gatagctggg tgacgaaagg cattaagcca gacgtcgaac agcagcatta tgtcatggcg      960

gttcttatcc ggggtggtgt attcggtgag aaaagcgaat aa                        1002


<210>  299
<211>  555
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(555)
<223>  Cas6

<400>  299
atggactatt tcctggatat tcgcgttctg cctgacccgg aatttagcga agagatgctt       60

atggccgcac tgtttgccaa actgcaccgc gctttaggag ccagaggcaa gggggatatt      120

ggcgtcagtt ttcctgagtt ttccgtcaag ccggggccat tattacgttt acatggtgat      180

gaatctgcac tgtgcgcgct ggaagaaacg ctctggcgta aagggctgaa tgattattgt      240

cagagtgggc agataatgcc ggtagaggaa ataaaaggat ggcgttgcgt cagtcgggta      300

caggtaaaaa gcagccccga gcggctgatg cgccgctcgg tgagaaaagg ctggctgaca      360

caggatgaag caaatgagcg attgcttagc atgcggggag agtcgacagc gctcccctgg      420

ttgaatatga aaagcctctc aaatgggcag aagtttccgc tatttatttg tcacggtgag      480

ctgctggcgc agcgcgtcgc gggaacattc aatagctatg ggctgagcca tatcgcgact      540

atcccctggt tttag                                                       555


<210>  300
<211>  1314
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(1314)
<223>  Cas8

<400>  300
atgacaaccg aggccctgac acactttatc atcgactaca tcgcctcccg gaagcagcca       60

aagctggatg ccttcgagaa ggaggccgcc aagagactgg cccagggaga ggacgcagga      120

gcaatcgccc aggagaggca ggagctggag gtgaagtatc agccaaggaa ctggctgacc      180

gatgcagcaa ggagggcagg acagatcagc ctggtgaccc acgccgccaa gttcacacac      240

ggcgactcca agtcctctag catctacaga gagaccgtgg gcgatgaggg ctatctgtcc      300

acagccgtgc tggccaatgt ggcagcagac gcagtgggaa acgcagccgc cctggatgtg      360

gcaaagctgc tgcagacaga agtgggaggc gacagcctgc tggcctgtct gaagaggggc      420

gatcgctccc cactgatggg ctttgccgag aatgacgcac agctggccct gtggatggag      480

ggcttctccc aggccctgac cccagcccag cctacatctc acaagctggc caagcagatc      540

tactttcctg tggatggcgg ctatcacctg ctgagcccac tgttcgcctc ctctctggcc      600

caggccatgc acgagaagat ggtggcagca aggtttggag agcaggcaaa ggcagcaaga      660

gaggcaagga gagccggcaa gtggcacgca cagccagacg tgcgctaccc taacgtggcc      720

gagatgcact tcggcggcac caagccccag aatatctccg ccctgaacag ctcccgggga      780

ggcagagtgt ggctgctgcc ctctcagccc cctaagtgga ccatgctgga caaggcccct      840

cagaatctga caagcctgtt tgccctgaga ggcgacttca acagggccgc cacagatacc      900

gtgagccgga tggtgtccct gctgaaggag aagacagata acaataacag gcacatccgc      960

aatgcaaggg caggatacgt ggacgagctg atcgatctgc tgtttctgca cgccgccacc     1020

tatcagcagg aggcctggca gggctggaca ctgaactccc cagacctgcc actgcaccag     1080

cagctgtggc tggacccctg gaggtccaag acagatgaga cctttagatc tgagagggag     1140

aagggcgact ggcagcgcag cgtggcagac gatttcgcaa ggtggctgaa ttaccggctg     1200

aacaaggcca gactggatgt gggaatcgca gagaggaggg agtggcagac ccagcggctg     1260

ttcagccagc ggatgagaga gatggaggcc atcgtgcagg aggccctgaa gtaa           1314


<210>  301
<211>  936
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(936)
<223>  Cas5

<400>  301
atgtcttacc tgctgctgct gccccacatc cgcatcgaga atgcaaacgc agtggcagga       60

ctgacctggg gatttcctgc catcacacac ttcctgggct atgtgcacgc cctgtcccgg      120

agagtgtctg agtttggcgt gtccttcacc ggctgcgccg tgatcaatca cgagcaccac      180

atccaggcct actcctctgg ccgggactat cagtttgccc tgacaagaaa tcctctgacc      240

aaggagggca agacagccgc cttcaacgag gagggcagaa tgcacctgac cgtgagcctg      300

ctggtggagt gtcagggcga gatcatcaat ggagagtacg gcaaggccgc cctgtgcagc      360

tccctgctga ccctgtgcca gagccacaag ctggccggag gctccatcgt gatgatgagg      420

gagccacaga tctttaacgc ccccgacgat gagaggaccc tgcgcaagat cctgtggagg      480

ctgatgccag gattcgcact gtgcgatagg tccgagtggc tgatggagca ctacaggcag      540

ctgcagcaga ggcgccctga gtctagcctg ctggacgcct ggctggattt cgccgccatc      600

aagtatcagc ctgtgcagca ggagccagag gacagcatgt cctgggagta ccagcccaag      660

cctaagccag gctatctggt gcccctgatg tgcggctacc agcggatcag cagactgtat      720

cagccaggcg aggtggccaa cgtgagggat accacaaccc ccttcgcctt taccgaggcc      780

gtgtacggag tgggagagtg gagaggactg cacaggatcg ccgacctgga gccactgatc      840

tggaggtatc gcacatctga taccggctac tattgcagcg ccatgcccgt ggccgacgat      900

gacttcatct ttaatgagga tgacgatctg gagtaa                                936


<210>  302
<211>  1002
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(1002)
<223>  Cas7

<400>  302
atggcaaagg cacccgtgtc tgtgaagacc gccagcgtgc tggcctttga gaggaagctg       60

gccacatccg acgccatgat gtacgccggc aactggctgg gcgattcttg gcagcctatc      120

gagatcaagg agaaggccgt gaggggcacc atcagcaatc gcctgaagaa cgccatcgcc      180

tccgacgcca caaagctgga tgccgagatc cagaaggcaa atctgcagcg ggtggacacc      240

gccgccctgc cagccgacgc cgataccctg aaggtggtgt tcacactgag agtgctggga      300

aacctggcaa ccccaagcgt gtgcaatgat atggcctacc agaacgccat ccagcagaca      360

atcgagggct atatcagcga gcacggattt gcagagctgg cccggagata cgccgccaat      420

ctggccaacg gcagattcct gtggcggaat agaatcggcg ccgagcagat ccaggtgtct      480

gtgagcgccc agggacaggc ctgggtgttt aacggccacg actattccct gagggagttc      540

tctcaggacg atgaggagat cgcctctctg gccgccctga tcgagcaggg actgagcggc      600

caggcctggg tcatgctgac cgtggaggca caggtgcggc tgggagcagg ccaggaggtg      660

tttccatctc aggagctggt gctggatagc aatagctcca agtcccgcgt gctgtaccag      720

gtggcaggaa tcgcaggcat ccacagccag aagatcggca acgccctgcg gacaatcgac      780

acctggcacc ccaaggtgga tgagctggga gcaatcgcag tggagcctta cggcagcgtg      840

acctcccgcg gaatggcatg caggcagccc aaggacaaga tggacttcta caccctgctg      900

gactcctggg tgacaaaggg catcaagcct gatgtggagc agcagcacta cgtgatggcc      960

gtgctgatca ggggaggcgt gttcggcgag aagtctgagt aa                        1002


<210>  303
<211>  555
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(555)
<223>  Cas6

<400>  303
atggactact tcctggatat cagagtgctg ccagaccccg agttttccga ggagatgctg       60

atggccgccc tgttcgccaa gctgcacaga gccctgggag caaggggcaa gggcgatatc      120

ggcgtgtctt ttccagagtt cagcgtgaag cctggaccac tgctgaggct gcacggcgac      180

gagtccgccc tgtgcgccct ggaggagacc ctgtggagaa agggcctgaa tgattattgt      240

cagtctggcc agatcatgcc tgtggaggag atcaagggat ggagatgcgt gagccgggtg      300

caggtgaagt ctagcccaga gaggctgatg aggcgcagcg tgcgcaaggg atggctgacc      360

caggacgagg caaacgagcg cctgctgtcc atgaggggag agtctacagc cctgccttgg      420

ctgaatatga agtccctgtc taacggccag aagtttccac tgttcatctg ccacggagag      480

ctgctggccc agcgcgtggc aggcaccttt aattcttacg gcctgagcca catcgccaca      540

atcccttggt tctaa                                                       555


<210>  304
<211>  437
<212>  PRT
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(437)
<223>  Cas8

<400>  304

Met Thr Thr Glu Ala Leu Thr His Phe Ile Ile Asp Tyr Ile Ala Ser 
1               5                   10                  15      


Arg Lys Gln Pro Lys Leu Asp Ala Phe Glu Lys Glu Ala Ala Lys Arg 
            20                  25                  30          


Leu Ala Gln Gly Glu Asp Ala Gly Ala Ile Ala Gln Glu Arg Gln Glu 
        35                  40                  45              


Leu Glu Val Lys Tyr Gln Pro Arg Asn Trp Leu Thr Asp Ala Ala Arg 
    50                  55                  60                  


Arg Ala Gly Gln Ile Ser Leu Val Thr His Ala Ala Lys Phe Thr His 
65                  70                  75                  80  


Gly Asp Ser Lys Ser Ser Ser Ile Tyr Arg Glu Thr Val Gly Asp Glu 
                85                  90                  95      


Gly Tyr Leu Ser Thr Ala Val Leu Ala Asn Val Ala Ala Asp Ala Val 
            100                 105                 110         


Gly Asn Ala Ala Ala Leu Asp Val Ala Lys Leu Leu Gln Thr Glu Val 
        115                 120                 125             


Gly Gly Asp Ser Leu Leu Ala Cys Leu Lys Arg Gly Asp Arg Ser Pro 
    130                 135                 140                 


Leu Met Gly Phe Ala Glu Asn Asp Ala Gln Leu Ala Leu Trp Met Glu 
145                 150                 155                 160 


Gly Phe Ser Gln Ala Leu Thr Pro Ala Gln Pro Thr Ser His Lys Leu 
                165                 170                 175     


Ala Lys Gln Ile Tyr Phe Pro Val Asp Gly Gly Tyr His Leu Leu Ser 
            180                 185                 190         


Pro Leu Phe Ala Ser Ser Leu Ala Gln Ala Met His Glu Lys Met Val 
        195                 200                 205             


Ala Ala Arg Phe Gly Glu Gln Ala Lys Ala Ala Arg Glu Ala Arg Arg 
    210                 215                 220                 


Ala Gly Lys Trp His Ala Gln Pro Asp Val Arg Tyr Pro Asn Val Ala 
225                 230                 235                 240 


Glu Met His Phe Gly Gly Thr Lys Pro Gln Asn Ile Ser Ala Leu Asn 
                245                 250                 255     


Ser Ser Arg Gly Gly Arg Val Trp Leu Leu Pro Ser Gln Pro Pro Lys 
            260                 265                 270         


Trp Thr Met Leu Asp Lys Ala Pro Gln Asn Leu Thr Ser Leu Phe Ala 
        275                 280                 285             


Leu Arg Gly Asp Phe Asn Arg Ala Ala Thr Asp Thr Val Ser Arg Met 
    290                 295                 300                 


Val Ser Leu Leu Lys Glu Lys Thr Asp Asn Asn Asn Arg His Ile Arg 
305                 310                 315                 320 


Asn Ala Arg Ala Gly Tyr Val Asp Glu Leu Ile Asp Leu Leu Phe Leu 
                325                 330                 335     


His Ala Ala Thr Tyr Gln Gln Glu Ala Trp Gln Gly Trp Thr Leu Asn 
            340                 345                 350         


Ser Pro Asp Leu Pro Leu His Gln Gln Leu Trp Leu Asp Pro Trp Arg 
        355                 360                 365             


Ser Lys Thr Asp Glu Thr Phe Arg Ser Glu Arg Glu Lys Gly Asp Trp 
    370                 375                 380                 


Gln Arg Ser Val Ala Asp Asp Phe Ala Arg Trp Leu Asn Tyr Arg Leu 
385                 390                 395                 400 


Asn Lys Ala Arg Leu Asp Val Gly Ile Ala Glu Arg Arg Glu Trp Gln 
                405                 410                 415     


Thr Gln Arg Leu Phe Ser Gln Arg Met Arg Glu Met Glu Ala Ile Val 
            420                 425                 430         


Gln Glu Ala Leu Lys 
        435         


<210>  305
<211>  311
<212>  PRT
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(311)
<223>  Cas5

<400>  305

Met Ser Tyr Leu Leu Leu Leu Pro His Ile Arg Ile Glu Asn Ala Asn 
1               5                   10                  15      


Ala Val Ala Gly Leu Thr Trp Gly Phe Pro Ala Ile Thr His Phe Leu 
            20                  25                  30          


Gly Tyr Val His Ala Leu Ser Arg Arg Val Ser Glu Phe Gly Val Ser 
        35                  40                  45              


Phe Thr Gly Cys Ala Val Ile Asn His Glu His His Ile Gln Ala Tyr 
    50                  55                  60                  


Ser Ser Gly Arg Asp Tyr Gln Phe Ala Leu Thr Arg Asn Pro Leu Thr 
65                  70                  75                  80  


Lys Glu Gly Lys Thr Ala Ala Phe Asn Glu Glu Gly Arg Met His Leu 
                85                  90                  95      


Thr Val Ser Leu Leu Val Glu Cys Gln Gly Glu Ile Ile Asn Gly Glu 
            100                 105                 110         


Tyr Gly Lys Ala Ala Leu Cys Ser Ser Leu Leu Thr Leu Cys Gln Ser 
        115                 120                 125             


His Lys Leu Ala Gly Gly Ser Ile Val Met Met Arg Glu Pro Gln Ile 
    130                 135                 140                 


Phe Asn Ala Pro Asp Asp Glu Arg Thr Leu Arg Lys Ile Leu Trp Arg 
145                 150                 155                 160 


Leu Met Pro Gly Phe Ala Leu Cys Asp Arg Ser Glu Trp Leu Met Glu 
                165                 170                 175     


His Tyr Arg Gln Leu Gln Gln Arg Arg Pro Glu Ser Ser Leu Leu Asp 
            180                 185                 190         


Ala Trp Leu Asp Phe Ala Ala Ile Lys Tyr Gln Pro Val Gln Gln Glu 
        195                 200                 205             


Pro Glu Asp Ser Met Ser Trp Glu Tyr Gln Pro Lys Pro Lys Pro Gly 
    210                 215                 220                 


Tyr Leu Val Pro Leu Met Cys Gly Tyr Gln Arg Ile Ser Arg Leu Tyr 
225                 230                 235                 240 


Gln Pro Gly Glu Val Ala Asn Val Arg Asp Thr Thr Thr Pro Phe Ala 
                245                 250                 255     


Phe Thr Glu Ala Val Tyr Gly Val Gly Glu Trp Arg Gly Leu His Arg 
            260                 265                 270         


Ile Ala Asp Leu Glu Pro Leu Ile Trp Arg Tyr Arg Thr Ser Asp Thr 
        275                 280                 285             


Gly Tyr Tyr Cys Ser Ala Met Pro Val Ala Asp Asp Asp Phe Ile Phe 
    290                 295                 300                 


Asn Glu Asp Asp Asp Leu Glu 
305                 310     


<210>  306
<211>  333
<212>  PRT
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(333)
<223>  Cas7

<400>  306

Met Ala Lys Ala Pro Val Ser Val Lys Thr Ala Ser Val Leu Ala Phe 
1               5                   10                  15      


Glu Arg Lys Leu Ala Thr Ser Asp Ala Met Met Tyr Ala Gly Asn Trp 
            20                  25                  30          


Leu Gly Asp Ser Trp Gln Pro Ile Glu Ile Lys Glu Lys Ala Val Arg 
        35                  40                  45              


Gly Thr Ile Ser Asn Arg Leu Lys Asn Ala Ile Ala Ser Asp Ala Thr 
    50                  55                  60                  


Lys Leu Asp Ala Glu Ile Gln Lys Ala Asn Leu Gln Arg Val Asp Thr 
65                  70                  75                  80  


Ala Ala Leu Pro Ala Asp Ala Asp Thr Leu Lys Val Val Phe Thr Leu 
                85                  90                  95      


Arg Val Leu Gly Asn Leu Ala Thr Pro Ser Val Cys Asn Asp Met Ala 
            100                 105                 110         


Tyr Gln Asn Ala Ile Gln Gln Thr Ile Glu Gly Tyr Ile Ser Glu His 
        115                 120                 125             


Gly Phe Ala Glu Leu Ala Arg Arg Tyr Ala Ala Asn Leu Ala Asn Gly 
    130                 135                 140                 


Arg Phe Leu Trp Arg Asn Arg Ile Gly Ala Glu Gln Ile Gln Val Ser 
145                 150                 155                 160 


Val Ser Ala Gln Gly Gln Ala Trp Val Phe Asn Gly His Asp Tyr Ser 
                165                 170                 175     


Leu Arg Glu Phe Ser Gln Asp Asp Glu Glu Ile Ala Ser Leu Ala Ala 
            180                 185                 190         


Leu Ile Glu Gln Gly Leu Ser Gly Gln Ala Trp Val Met Leu Thr Val 
        195                 200                 205             


Glu Ala Gln Val Arg Leu Gly Ala Gly Gln Glu Val Phe Pro Ser Gln 
    210                 215                 220                 


Glu Leu Val Leu Asp Ser Asn Ser Ser Lys Ser Arg Val Leu Tyr Gln 
225                 230                 235                 240 


Val Ala Gly Ile Ala Gly Ile His Ser Gln Lys Ile Gly Asn Ala Leu 
                245                 250                 255     


Arg Thr Ile Asp Thr Trp His Pro Lys Val Asp Glu Leu Gly Ala Ile 
            260                 265                 270         


Ala Val Glu Pro Tyr Gly Ser Val Thr Ser Arg Gly Met Ala Cys Arg 
        275                 280                 285             


Gln Pro Lys Asp Lys Met Asp Phe Tyr Thr Leu Leu Asp Ser Trp Val 
    290                 295                 300                 


Thr Lys Gly Ile Lys Pro Asp Val Glu Gln Gln His Tyr Val Met Ala 
305                 310                 315                 320 


Val Leu Ile Arg Gly Gly Val Phe Gly Glu Lys Ser Glu 
                325                 330             


<210>  307
<211>  184
<212>  PRT
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(184)
<223>  Cas6

<400>  307

Met Asp Tyr Phe Leu Asp Ile Arg Val Leu Pro Asp Pro Glu Phe Ser 
1               5                   10                  15      


Glu Glu Met Leu Met Ala Ala Leu Phe Ala Lys Leu His Arg Ala Leu 
            20                  25                  30          


Gly Ala Arg Gly Lys Gly Asp Ile Gly Val Ser Phe Pro Glu Phe Ser 
        35                  40                  45              


Val Lys Pro Gly Pro Leu Leu Arg Leu His Gly Asp Glu Ser Ala Leu 
    50                  55                  60                  


Cys Ala Leu Glu Glu Thr Leu Trp Arg Lys Gly Leu Asn Asp Tyr Cys 
65                  70                  75                  80  


Gln Ser Gly Gln Ile Met Pro Val Glu Glu Ile Lys Gly Trp Arg Cys 
                85                  90                  95      


Val Ser Arg Val Gln Val Lys Ser Ser Pro Glu Arg Leu Met Arg Arg 
            100                 105                 110         


Ser Val Arg Lys Gly Trp Leu Thr Gln Asp Glu Ala Asn Glu Arg Leu 
        115                 120                 125             


Leu Ser Met Arg Gly Glu Ser Thr Ala Leu Pro Trp Leu Asn Met Lys 
    130                 135                 140                 


Ser Leu Ser Asn Gly Gln Lys Phe Pro Leu Phe Ile Cys His Gly Glu 
145                 150                 155                 160 


Leu Leu Ala Gln Arg Val Ala Gly Thr Phe Asn Ser Tyr Gly Leu Ser 
                165                 170                 175     


His Ile Ala Thr Ile Pro Trp Phe 
            180                 


<210>  308
<211>  88
<212>  DNA
<213>  Klebsiella oxytoca strain ICU1-2b


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  CRISPR

<400>  308
gttcactgcc gtacaggcag cttagaaaaa aaactgagcg gccgcagaat gaagttgtaa       60

gttcactgcc gtacaggcag cttagaaa                                          88


<210>  309
<211>  1305
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(1305)
<223>  Cas8

<400>  309
atgacctctc ccctcccaac gcctacgtgg caggagcttc gccagttcat cgaatccttc       60

atccaggagc gcctccaggg caagctggac aaactccaac ccgacgaaga cgacaagcgc      120

cagacattgc tggccaccca ccggcgggag gcctggctgg ccgatgccgc ccggcgggtt      180

ggccagttgc agttggtgac ccacacgctc aagccgatcc atcccgacgc ccgcggcagc      240

aacctgcaca gcctgccgca agcacccggc caaccgggcc tcgccggttc ccatgagcta      300

ggtgacaggc tggtcagcga tgtggtgggc aatgccgcgg cgctggacgt attcaagttt      360

ctcagtctcc agtatcaggg taaaaatctt ctgaactggc tgacagaaga cagtgccgag      420

gcattacagg cgctgtccga taacgccgaa caggctcgcg aatggcggca agcgttcatc      480

ggcatcacga ccgtcaaagg cgctcccgcg tcccacagcc tggccaagca gttgtacttt      540

cccctgcccg gttccggcta ccacctgcta gcaccgctgt ttcccaccag tctggtgcat      600

cacgtccacg ctctgctccg cgaagcgcgc ttcggcgacg cggccaaggc ggcacgcgaa      660

gcgcgcagcc gccaggagtc atggccccac ggattcagcg agtaccccaa cctggcgatc      720

cagaagttcg gcggtaccaa gccgcagaac atcagtcagt tgaacaacga gcgccgtggc      780

gagaactggt tgctgccatc gcttccgccg aactggcaaa ggcagaatgt aaacgcgccg      840

atgcggcact cttcggtctt cgagcatgac ttcggaagaa ctcctgaagt atcccgccta      900

acccgtaccc tgcagcgttt tcttgccaag acagtccata acaacctcgc catccgccag      960

cggcgtgccc aattggtggc gcaaatctgc gacgaagccc tgcaatacgc cgcccgtctg     1020

cgcgaactgg agcccggctg gagcgcaacc cccgggtgcc aactgcatga cgcggagcag     1080

ctctggctcg atccgttgcg cgcacagacc gatgagacgt tcttgcagcg ccgactacga     1140

ggtgactggc ctgccgaggt cggaaatcgc ttcgccaact ggctgaaccg ggcggtcagc     1200

agcgacagtc agatactggg tagcccggaa gccgcccaat ggagccagga gctgagcaag     1260

gaactgacga tgttcaagga gatactcgaa gatgagcgtg actga                     1305


<210>  310
<211>  984
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(984)
<223>  Cas5

<400>  310
atgagcgtga ctgatcccga ggcgctgctg ttgctgccac gcctgtccat ccagaacgcc       60

aacgccattt ccagcccctt gacctggggt ttcccttcgc ccggcgcttt caccggattc      120

gtccatgcct tgcagcgtcg agtcggaatc tccctcgata tcgaactgga cggtgtcggc      180

atcgtctgtc accgcttcga agcgcagata tcgcaaccgg ccggcaagcg caccaaggtc      240

ttcaacctga cccgcaatcc gctgaaccgc gacggctcca ccgcagccat cgtcgaagaa      300

ggtcgcgccc atctggaggt cagtctgctg ctcggagtgc atggcgatgg tctggacgat      360

caccccgcac aggaaatcgc caggcaggta caggagcagg ctggcgccat gcgcctcgcc      420

ggtggcagca tcctgccctg gtgcaatgag cgcttcccgg ctccgaacgc cgaactgctg      480

atgctgggtg gcagcgacga acagcggcgc aagaaccagc gccggcttac ccgccgcctg      540

ctccccggct tcgccctggt gagtcgcgag gcgttgttgc aacaacatct ggaaaccttg      600

cgcaccacgc tccccgaagc caccacgctc gatgcactgc tcgatctttg tcgaatcaac      660

ttcgagcctc ctgcaacctc gtccgaagaa gaagcatcgc cgcccgatgc agcctggcaa      720

gtgcgcgaca agcccggctg gctggtgccg atcccggctg gctacaacgc cctgtcaccc      780

ctgtacctcc ccggcgaagt gcgaaatgcc cgtgatagag aaacaccgct gcgcttcgtc      840

gaaaacctct tcggtctggg cgaatggctc agcccccatc gcgtcgccgc gttatcggac      900

ctgctttggt atcaccacgc cgagcctgac aaagggctct accgctggag cacaccccgt      960

ttcgtcgaac acgccatcgc ataa                                             984


<210>  311
<211>  1029
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(1029)
<223>  Cas7

<400>  311
atgtccaagc caatactgag caccgcttcc gtcctcgcct tcgaacgtaa gctcgaccct       60

tccgacgccc ttatgagcgc tggcgcctgg gcgcaacgcg acgcctcgca ggaatggccg      120

gccgtgaccg tgcgcgagaa gtccgtacgc ggcaccatct ccaaccgcct caagaccaag      180

gaccgtgacc cggccaagct ggacgcctcg atccagtcgc ccaacctgca gacggtggac      240

gtggccaacc tgccgagcga cgccgacacc ctcaaggtcc gcttcaccct ccgtgtgctc      300

ggcggcgccg gaacaccgtc tgcctgcaac gacgcggcct accgtgacaa gctgctgcaa      360

acggtcgcca cctacgtgaa cgatcagggc ttcgccgagc tggctcgtcg ttatgcgcac      420

aacctggcca acgcccgctt cctgtggcgc aaccgggtgg gcgcggaagc ggtggaagtc      480

cgtatcaacc atatccgcca gggcgaggtg gctcgcgcct ggcgcttcga cgccctggcc      540

atcggcttgc gcgacttcaa ggccgacgcc gaactggacg cgctcgccga actgatcgcc      600

agcggtctct caggcagtgg gcatgtcctg ctcgaagtgg tcgccttcgc ccgtatcggc      660

gacggccagg aagtcttccc ctcccaggaa ctgatcctcg acaaaggcga caagaaaggc      720

cagaagagca agaccctgta cagcgtacgc gatgccgcgg ccatccactc gcagaagatc      780

ggcaatgccc tgcgcaccat cgatacgtgg tatcccgacg aagatggcct cggccccatc      840

gccgtggagc cctacggctc cgtcacatcc cagggcaaag cctatcgcca gcccaagcag      900

aagctggact tctatacgct gctcgacaac tgggtactgc gcgacgaggc gcccgccgtg      960

gagcaacagc attatgtgat cgccaacctg atccgtggcg gcgtgttcgg tgaagccgaa     1020

gagaagtaa                                                             1029


<210>  312
<211>  564
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(564)
<223>  Cas6

<400>  312
atggaccact acctcgacat tcgcttgcga ccggacccgg aatttccccc ggcgcaactc       60

atgagcgtgc tcttcggcaa gctccaccag gccctggtgg cacagggcgg ggacaggatc      120

ggcgtgagct tccccgacct cgacgaaagc cgctcccggc tgggcgagcg cctgcgcatt      180

catgcctcgg cggacgacct tcgtgccctg ctcgcccggc cctggctgga agggttgcgg      240

gaccatctgc aattcggaga accggcagtc gtgcctcacc ccacaccgta ccgtcaggtc      300

agtcgggttc aggcgaaaag caatccggaa cgcctgcggc ggcggctcat gcgccggcac      360

gatctgagtg aggaggaggc tcggaaacgc attcccgata cggtcgcgag agccttggac      420

ctgcccttcg tcacgctacg cagccagagc accggacagc acttccgtct cttcatccgc      480

cacgggccgt tgcaggtgac ggcagaggaa ggaggattca cctgttacgg gttgagcaaa      540

ggaggtttcg ttccctggtt ctga                                             564


<210>  313
<211>  1305
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(1305)
<223>  Cas8

<400>  313
atgacatctc ctctgccaac ccccacatgg caggagctga gacagtttat cgagagcttc       60

atccaggaga ggctgcaggg caagctggat aagctgcagc ctgacgagga cgataagcgg      120

cagaccctgc tggccacaca cagaagggag gcctggctgg ccgatgcagc acgccgggtg      180

ggacagctgc agctggtgac ccacacactg aagccaatcc accctgacgc aaggggctct      240

aatctgcaca gcctgccaca ggcaccagga cagcctggcc tggccggctc tcacgagctg      300

ggcgataggc tggtgagcga cgtggtggga aacgcagccg ccctggacgt gtttaagttc      360

ctgtccctgc agtaccaggg caagaacctg ctgaattggc tgaccgagga tagcgccgag      420

gccctgcagg ccctgtccga caatgcagag caggcaagag agtggaggca ggcctttatc      480

ggaatcacca cagtgaaggg agcaccagcc agccactccc tggccaagca gctgtacttt      540

cctctgccag gcagcggcta tcacctgctg gccccactgt tccccacctc cctggtgcac      600

cacgtgcacg ccctgctgag ggaggcaagg ttcggcgacg cagccaaggc cgccagagag      660

gcacgctccc ggcaggagtc ttggccacac ggctttagcg agtaccctaa tctggccatc      720

cagaagttcg gcggcaccaa gccccagaac atctcccagc tgaacaatga gagaaggggc      780

gagaactggc tgctgccttc tctgccccct aattggcaga gacagaacgt gaatgcccca      840

atgaggcact ccagcgtgtt cgagcacgat ttcggccgca cccctgaggt gagcagactg      900

accaggacac tgcagcggtt cctggccaag acagtgcaca acaatctggc catcagacag      960

aggagggcac agctggtggc acagatctgc gacgaggccc tgcagtacgc agcaagactg     1020

agggagctgg agccaggatg gtccgccacc ccaggctgtc agctgcacga cgcagagcag     1080

ctgtggctgg accccctgag ggcacagacc gacgagacat ttctgcagag aaggctgagg     1140

ggcgattggc cagcagaagt gggaaacagg ttcgcaaact ggctgaatcg ggccgtgagc     1200

tccgactctc agatcctggg cagccccgag gcagcacagt ggagccagga gctgtccaag     1260

gagctgacca tgttcaagga gatcctggag gacgagaggg attaa                     1305


<210>  314
<211>  984
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(984)
<223>  Cas5

<400>  314
atgtctgtga cagaccctga ggccctgctg ctgctgccaa gactgagcat ccagaacgcc       60

aatgccatca gctccccact gacctgggga ttcccttccc caggcgcctt tacaggattc      120

gtgcacgccc tgcagcgccg ggtgggcatc tccctggata tcgagctgga cggagtggga      180

atcgtgtgcc accgctttga ggcccagatc tctcagccag ccggcaagcg gaccaaggtg      240

ttcaacctga cacgcaaccc cctgaatcgg gatggctcta ccgcagcaat cgtggaggag      300

ggaagagcac acctggaggt gagcctgctg ctgggagtgc acggcgacgg cctggacgat      360

cacccagccc aggagatcgc aagacaggtg caggagcagg caggagcaat gaggctggcc      420

ggaggctcta tcctgccatg gtgcaacgag aggtttcccg cccctaatgc agagctgctg      480

atgctgggag gcagcgacga gcagagaagg aagaatcagc gccggctgac cagaaggctg      540

ctgccaggat tcgcactggt gagcagagag gccctgctgc agcagcacct ggagacactg      600

aggaccacac tgcctgaggc aaccaccctg gacgccctgc tggacctgtg cagaatcaac      660

tttgagccac ctgccacctc tagcgaggag gaggccagcc cacccgacgc agcctggcag      720

gtgagggata agcctggatg gctggtgcca atcccagcag gatacaacgc cctgtcccct      780

ctgtatctgc caggcgaggt gcgcaatgcc agagataggg agacacccct gcggtttgtg      840

gagaacctgt tcggcctggg cgagtggctg tctcctcaca gggtggccgc cctgagcgat      900

ctgctgtggt atcaccacgc cgagcctgac aagggcctgt acagatggag caccccaagg      960

ttcgtggagc acgcaatcgc ataa                                             984


<210>  315
<211>  1029
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(1029)
<223>  Cas7

<400>  315
atgagcaagc ccatcctgtc caccgcctct gtgctggcct ttgagcggaa gctggaccct       60

tctgatgccc tgatgagcgc cggagcatgg gcacagagag atgccagcca ggagtggcca      120

gccgtgacag tgagagagaa gtccgtgagg ggcaccatct ctaaccgcct gaagacaaag      180

gaccgggacc ccgcaaagct ggatgccagc atccagtccc ctaacctgca gaccgtggac      240

gtggccaatc tgccaagcga cgccgatacc ctgaaggtgc gcttcacact gcgggtgctg      300

ggaggagcag gaacaccatc cgcctgcaat gatgccgcct atagagacaa gctgctgcag      360

accgtggcca catacgtgaa cgaccaggga tttgcagagc tggcccggag atacgcccac      420

aacctggcca atgccaggtt cctgtggagg aacagggtgg gagcagaggc agtggaggtg      480

cgcatcaatc acatcaggca gggagaggtg gcaagggcat ggcggtttga tgccctggcc      540

atcggcctga gagacttcaa ggcagatgca gagctggacg ccctggccga gctgatcgcc      600

agcggcctgt ctggcagcgg ccacgtgctg ctggaggtgg tggcctttgc caggatcggc      660

gacggccagg aggtgttccc ttcccaggag ctgatcctgg acaagggcga taagaagggc      720

cagaagtcca agaccctgta ctctgtgcgg gatgcagcag caatccacag ccagaagatc      780

ggcaatgccc tgagaaccat cgacacatgg tatccagacg aggatggact gggaccaatc      840

gcagtggagc cttacggctc tgtgaccagc cagggcaagg cctataggca gcccaagcag      900

aagctggact tctacacact gctggacaat tgggtgctga gggatgaggc acctgcagtg      960

gagcagcagc actacgtgat cgccaacctg atcaggggag gcgtgttcgg agaggcagag     1020

gagaagtaa                                                             1029


<210>  316
<211>  564
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(564)
<223>  Cas6

<400>  316
atggatcact atctggacat cagactgagg ccagatcccg agtttccacc cgcccagctg       60

atgtctgtgc tgttcggcaa gctgcaccag gccctggtgg cacagggagg cgaccggatc      120

ggcgtgtctt ttccagacct ggatgagtcc cgctctcggc tgggagagcg gctgagaatc      180

cacgccagcg ccgacgatct gagagccctg ctggccaggc catggctgga gggactgcgc      240

gatcacctgc agttcggaga gcctgcagtg gtgcctcacc caacccccta cagacaggtg      300

tctagggtgc aggccaagag caacccagag cggctgaggc gccggctgat gagaaggcac      360

gacctgagcg aggaggaggc aaggaagaga atccccgaca cagtggcacg cgccctggat      420

ctgccctttg tgaccctgcg gagccagtcc acaggccagc actttcgcct gttcatcagg      480

cacggaccac tgcaggtgac cgcagaggag ggaggcttca catgctatgg cctgtccaag      540

ggcggctttg tgccttggtt ctaa                                             564


<210>  317
<211>  434
<212>  PRT
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(434)
<223>  Cas8

<400>  317

Met Thr Ser Pro Leu Pro Thr Pro Thr Trp Gln Glu Leu Arg Gln Phe 
1               5                   10                  15      


Ile Glu Ser Phe Ile Gln Glu Arg Leu Gln Gly Lys Leu Asp Lys Leu 
            20                  25                  30          


Gln Pro Asp Glu Asp Asp Lys Arg Gln Thr Leu Leu Ala Thr His Arg 
        35                  40                  45              


Arg Glu Ala Trp Leu Ala Asp Ala Ala Arg Arg Val Gly Gln Leu Gln 
    50                  55                  60                  


Leu Val Thr His Thr Leu Lys Pro Ile His Pro Asp Ala Arg Gly Ser 
65                  70                  75                  80  


Asn Leu His Ser Leu Pro Gln Ala Pro Gly Gln Pro Gly Leu Ala Gly 
                85                  90                  95      


Ser His Glu Leu Gly Asp Arg Leu Val Ser Asp Val Val Gly Asn Ala 
            100                 105                 110         


Ala Ala Leu Asp Val Phe Lys Phe Leu Ser Leu Gln Tyr Gln Gly Lys 
        115                 120                 125             


Asn Leu Leu Asn Trp Leu Thr Glu Asp Ser Ala Glu Ala Leu Gln Ala 
    130                 135                 140                 


Leu Ser Asp Asn Ala Glu Gln Ala Arg Glu Trp Arg Gln Ala Phe Ile 
145                 150                 155                 160 


Gly Ile Thr Thr Val Lys Gly Ala Pro Ala Ser His Ser Leu Ala Lys 
                165                 170                 175     


Gln Leu Tyr Phe Pro Leu Pro Gly Ser Gly Tyr His Leu Leu Ala Pro 
            180                 185                 190         


Leu Phe Pro Thr Ser Leu Val His His Val His Ala Leu Leu Arg Glu 
        195                 200                 205             


Ala Arg Phe Gly Asp Ala Ala Lys Ala Ala Arg Glu Ala Arg Ser Arg 
    210                 215                 220                 


Gln Glu Ser Trp Pro His Gly Phe Ser Glu Tyr Pro Asn Leu Ala Ile 
225                 230                 235                 240 


Gln Lys Phe Gly Gly Thr Lys Pro Gln Asn Ile Ser Gln Leu Asn Asn 
                245                 250                 255     


Glu Arg Arg Gly Glu Asn Trp Leu Leu Pro Ser Leu Pro Pro Asn Trp 
            260                 265                 270         


Gln Arg Gln Asn Val Asn Ala Pro Met Arg His Ser Ser Val Phe Glu 
        275                 280                 285             


His Asp Phe Gly Arg Thr Pro Glu Val Ser Arg Leu Thr Arg Thr Leu 
    290                 295                 300                 


Gln Arg Phe Leu Ala Lys Thr Val His Asn Asn Leu Ala Ile Arg Gln 
305                 310                 315                 320 


Arg Arg Ala Gln Leu Val Ala Gln Ile Cys Asp Glu Ala Leu Gln Tyr 
                325                 330                 335     


Ala Ala Arg Leu Arg Glu Leu Glu Pro Gly Trp Ser Ala Thr Pro Gly 
            340                 345                 350         


Cys Gln Leu His Asp Ala Glu Gln Leu Trp Leu Asp Pro Leu Arg Ala 
        355                 360                 365             


Gln Thr Asp Glu Thr Phe Leu Gln Arg Arg Leu Arg Gly Asp Trp Pro 
    370                 375                 380                 


Ala Glu Val Gly Asn Arg Phe Ala Asn Trp Leu Asn Arg Ala Val Ser 
385                 390                 395                 400 


Ser Asp Ser Gln Ile Leu Gly Ser Pro Glu Ala Ala Gln Trp Ser Gln 
                405                 410                 415     


Glu Leu Ser Lys Glu Leu Thr Met Phe Lys Glu Ile Leu Glu Asp Glu 
            420                 425                 430         


Arg Asp 
        


<210>  318
<211>  327
<212>  PRT
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(327)
<223>  Cas5

<400>  318

Met Ser Val Thr Asp Pro Glu Ala Leu Leu Leu Leu Pro Arg Leu Ser 
1               5                   10                  15      


Ile Gln Asn Ala Asn Ala Ile Ser Ser Pro Leu Thr Trp Gly Phe Pro 
            20                  25                  30          


Ser Pro Gly Ala Phe Thr Gly Phe Val His Ala Leu Gln Arg Arg Val 
        35                  40                  45              


Gly Ile Ser Leu Asp Ile Glu Leu Asp Gly Val Gly Ile Val Cys His 
    50                  55                  60                  


Arg Phe Glu Ala Gln Ile Ser Gln Pro Ala Gly Lys Arg Thr Lys Val 
65                  70                  75                  80  


Phe Asn Leu Thr Arg Asn Pro Leu Asn Arg Asp Gly Ser Thr Ala Ala 
                85                  90                  95      


Ile Val Glu Glu Gly Arg Ala His Leu Glu Val Ser Leu Leu Leu Gly 
            100                 105                 110         


Val His Gly Asp Gly Leu Asp Asp His Pro Ala Gln Glu Ile Ala Arg 
        115                 120                 125             


Gln Val Gln Glu Gln Ala Gly Ala Met Arg Leu Ala Gly Gly Ser Ile 
    130                 135                 140                 


Leu Pro Trp Cys Asn Glu Arg Phe Pro Ala Pro Asn Ala Glu Leu Leu 
145                 150                 155                 160 


Met Leu Gly Gly Ser Asp Glu Gln Arg Arg Lys Asn Gln Arg Arg Leu 
                165                 170                 175     


Thr Arg Arg Leu Leu Pro Gly Phe Ala Leu Val Ser Arg Glu Ala Leu 
            180                 185                 190         


Leu Gln Gln His Leu Glu Thr Leu Arg Thr Thr Leu Pro Glu Ala Thr 
        195                 200                 205             


Thr Leu Asp Ala Leu Leu Asp Leu Cys Arg Ile Asn Phe Glu Pro Pro 
    210                 215                 220                 


Ala Thr Ser Ser Glu Glu Glu Ala Ser Pro Pro Asp Ala Ala Trp Gln 
225                 230                 235                 240 


Val Arg Asp Lys Pro Gly Trp Leu Val Pro Ile Pro Ala Gly Tyr Asn 
                245                 250                 255     


Ala Leu Ser Pro Leu Tyr Leu Pro Gly Glu Val Arg Asn Ala Arg Asp 
            260                 265                 270         


Arg Glu Thr Pro Leu Arg Phe Val Glu Asn Leu Phe Gly Leu Gly Glu 
        275                 280                 285             


Trp Leu Ser Pro His Arg Val Ala Ala Leu Ser Asp Leu Leu Trp Tyr 
    290                 295                 300                 


His His Ala Glu Pro Asp Lys Gly Leu Tyr Arg Trp Ser Thr Pro Arg 
305                 310                 315                 320 


Phe Val Glu His Ala Ile Ala 
                325         


<210>  319
<211>  342
<212>  PRT
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(342)
<223>  Cas7

<400>  319

Met Ser Lys Pro Ile Leu Ser Thr Ala Ser Val Leu Ala Phe Glu Arg 
1               5                   10                  15      


Lys Leu Asp Pro Ser Asp Ala Leu Met Ser Ala Gly Ala Trp Ala Gln 
            20                  25                  30          


Arg Asp Ala Ser Gln Glu Trp Pro Ala Val Thr Val Arg Glu Lys Ser 
        35                  40                  45              


Val Arg Gly Thr Ile Ser Asn Arg Leu Lys Thr Lys Asp Arg Asp Pro 
    50                  55                  60                  


Ala Lys Leu Asp Ala Ser Ile Gln Ser Pro Asn Leu Gln Thr Val Asp 
65                  70                  75                  80  


Val Ala Asn Leu Pro Ser Asp Ala Asp Thr Leu Lys Val Arg Phe Thr 
                85                  90                  95      


Leu Arg Val Leu Gly Gly Ala Gly Thr Pro Ser Ala Cys Asn Asp Ala 
            100                 105                 110         


Ala Tyr Arg Asp Lys Leu Leu Gln Thr Val Ala Thr Tyr Val Asn Asp 
        115                 120                 125             


Gln Gly Phe Ala Glu Leu Ala Arg Arg Tyr Ala His Asn Leu Ala Asn 
    130                 135                 140                 


Ala Arg Phe Leu Trp Arg Asn Arg Val Gly Ala Glu Ala Val Glu Val 
145                 150                 155                 160 


Arg Ile Asn His Ile Arg Gln Gly Glu Val Ala Arg Ala Trp Arg Phe 
                165                 170                 175     


Asp Ala Leu Ala Ile Gly Leu Arg Asp Phe Lys Ala Asp Ala Glu Leu 
            180                 185                 190         


Asp Ala Leu Ala Glu Leu Ile Ala Ser Gly Leu Ser Gly Ser Gly His 
        195                 200                 205             


Val Leu Leu Glu Val Val Ala Phe Ala Arg Ile Gly Asp Gly Gln Glu 
    210                 215                 220                 


Val Phe Pro Ser Gln Glu Leu Ile Leu Asp Lys Gly Asp Lys Lys Gly 
225                 230                 235                 240 


Gln Lys Ser Lys Thr Leu Tyr Ser Val Arg Asp Ala Ala Ala Ile His 
                245                 250                 255     


Ser Gln Lys Ile Gly Asn Ala Leu Arg Thr Ile Asp Thr Trp Tyr Pro 
            260                 265                 270         


Asp Glu Asp Gly Leu Gly Pro Ile Ala Val Glu Pro Tyr Gly Ser Val 
        275                 280                 285             


Thr Ser Gln Gly Lys Ala Tyr Arg Gln Pro Lys Gln Lys Leu Asp Phe 
    290                 295                 300                 


Tyr Thr Leu Leu Asp Asn Trp Val Leu Arg Asp Glu Ala Pro Ala Val 
305                 310                 315                 320 


Glu Gln Gln His Tyr Val Ile Ala Asn Leu Ile Arg Gly Gly Val Phe 
                325                 330                 335     


Gly Glu Ala Glu Glu Lys 
            340         


<210>  320
<211>  187
<212>  PRT
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(187)
<223>  Cas6

<400>  320

Met Asp His Tyr Leu Asp Ile Arg Leu Arg Pro Asp Pro Glu Phe Pro 
1               5                   10                  15      


Pro Ala Gln Leu Met Ser Val Leu Phe Gly Lys Leu His Gln Ala Leu 
            20                  25                  30          


Val Ala Gln Gly Gly Asp Arg Ile Gly Val Ser Phe Pro Asp Leu Asp 
        35                  40                  45              


Glu Ser Arg Ser Arg Leu Gly Glu Arg Leu Arg Ile His Ala Ser Ala 
    50                  55                  60                  


Asp Asp Leu Arg Ala Leu Leu Ala Arg Pro Trp Leu Glu Gly Leu Arg 
65                  70                  75                  80  


Asp His Leu Gln Phe Gly Glu Pro Ala Val Val Pro His Pro Thr Pro 
                85                  90                  95      


Tyr Arg Gln Val Ser Arg Val Gln Ala Lys Ser Asn Pro Glu Arg Leu 
            100                 105                 110         


Arg Arg Arg Leu Met Arg Arg His Asp Leu Ser Glu Glu Glu Ala Arg 
        115                 120                 125             


Lys Arg Ile Pro Asp Thr Val Ala Arg Ala Leu Asp Leu Pro Phe Val 
    130                 135                 140                 


Thr Leu Arg Ser Gln Ser Thr Gly Gln His Phe Arg Leu Phe Ile Arg 
145                 150                 155                 160 


His Gly Pro Leu Gln Val Thr Ala Glu Glu Gly Gly Phe Thr Cys Tyr 
                165                 170                 175     


Gly Leu Ser Lys Gly Gly Phe Val Pro Trp Phe 
            180                 185         


<210>  321
<211>  88
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  CRISPR

<400>  321
gttcactgcc gtgtaggcag ctaagaaaac cacccgctac caccggcagc cgcaccggcc       60

gttcactgcc gtgtaggcag ctaagaaa                                          88


<210>  322
<211>  948
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(948)
<223>  Cas7

<400>  322
atgcaaaaag taacgggaat taaaagtgtt gattttaaaa ttaaagcatt aggtcatggc       60

gtagtgaatt ggaatgggcc tacaacctta accggtgatg acggtaaaac ggttgataat      120

cataccttgc caaaattgcg tggctacaca aacttgaccg gtaaagtgaa agatgaaacg      180

ggctataaat ataaaaaaca agcaactgac attaatttca aagaaacgcc actgtatata      240

agtcaaaatt gcattcgcca tcatttattt cgtgaacaag cattcgattt acattatgcc      300

agtgacaaaa acctcaaaaa tgtcctggct tcaattacag ggttgatccg tggttacgta      360

gtgccctcaa gtcaatgcaa acgcaccagt ccgctattgt tggaagattt tgttgatcaa      420

ttgggtaacg gcaattttga acaatatggg caggcaggag caagagatag tacatcattt      480

ttttcaaaga ccacttttgg ggatacagaa tacatctcct atggctctat tagtattgaa      540

cagttgcagt ttatatcgtt ggataagaag tttgatcgtg ctgcaatggt tatcaaagaa      600

ggagagggcg aggttattgc cgctgaacta cagaattata ttcagtcact taaccccagc      660

ttaaatccac aagccatttt tcattcaaac tacgtcagaa gaggcactat attcgaagag      720

ggagaatgcg gcattttact taatgatgat gcagtaaaag ccttggttgc tgaaacatta      780

gaacgcttag ctaatttgtc tattcgccaa gctaaaggtt atatgtacgt ggatgacatc      840

acggtggatt acaacgacag ccataaaatg atgcgtatca agcgtgatga gtcagaaatc      900

atcaatgagc agcatgcgcc atttgcacag tatttttatg caaaatag                   948


<210>  323
<211>  1011
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(1011)
<223>  Cas5

<400>  323
atgaaaataa tcatagaata tgactcttgc tggcgtaatg cctttttagg tggttcaaat       60

aatgaacctg taccgaaaaa aggccgcgaa tttttaggct caatgacgag cttaaaaaaa      120

gaaggcaatt ttaaggtgtg tgaaaatacc ttagataccg taatgggagt actaaatcgt      180

ttaattggcg accaacgaaa gctttatcag gcgcgcagta aaatgtacga atccgcttat      240

tacttcgaag cactggaaga taaagtcagc tttatagata agccgcagtt gaccaatgaa      300

atatcattta ttcgtaatat gaatggcagt acggatcaga atgcatttac tggaatgatc      360

aaagtgtctg atcctgtttt tacctctgaa tattcacagc aattttgggg cgtgttggct      420

ctcgatttca cgcagctctg tgattttatt attaagcaat cacaagttgt aggatctatt      480

gagttaaacc cgttaagtat tatcaatcgc ttggagagcc ttaatcagga aaaagcacta      540

gaaaatagtg atgatttagc ccaagtatta aaggtactaa atgaatactt tcctgatatt      600

gaatatttaa ataataaagg tttgatcaca cctatcagca tttattgctc ggcgctttac      660

cttcagcttg cccgcttaga aactagcttt aatatgacca cagctaaaac gaaagcaggg      720

gggattagtg gaatttccaa acgaggtttc actaaaaaag acttcatgga ccgatataca      780

acgggaccca aaaaaacaat ctggggtaat ccttttatca aaaaagaaaa gataaaaggg      840

caaggtgaag tgacctccat gatgaccaaa gcaagtggtc aattggaaat tagtatcgat      900

gtggatcgag acaaagccca agaaatcaaa attttgattg aaaatgctgg ggtatcaagc      960

ttttaccttg gaaaaaaagg gctggcctat gtatcaaaca ttaagcttta g              1011


<210>  324
<211>  552
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(552)
<223>  Cas6

<400>  324
atgaactcat atattgatat acggctgaag cctgatgccg aaatgcggga ggctgagctc       60

agtagtaaag tatttactaa atttcacaaa gcgttagtga cgctcaatag ccataaaatt      120

ggcattagct ttccgcaaat gaaattaagc ttagggcagt tatttcgcat tcatggtgat      180

gcgagtttat tgcatgattt acaaggcctg gattggttag gccctttggc aggatattgt      240

caggttactg ctgtttctgc cgtgcctgat cacgtgcaat atcgtattgt ttccgttaaa      300

cgcagtaatt taagtaaagc aaaattgaag cgtttaattg ccagaggcag catagataaa      360

gacggagaga aacggtacaa ggtaaaaatg ctcggccaag gatttgataa tccatatctt      420

gatctgttta gtagttccac agggcaggta tatcgtaaat tctttgagtt tagcgacatt      480

caagctcacc cccttgatgg tgagtttgat agttatggtc ttagcaaaac cgctacagta      540

ccttggtttt aa                                                          552


<210>  325
<211>  948
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(948)
<223>  Cas7

<400>  325
atgcagaagg tgaccggcat caagtccgtg gacttcaaga tcaaggccct gggccacggc       60

gtggtgaact ggaatggccc caccacactg acaggcgacg atggcaagac cgtggacaat      120

cacacactgc ctaagctgag aggctacacc aacctgacag gcaaggtgaa ggatgagacc      180

ggctacaagt ataagaagca ggccaccgac atcaatttca aggagacacc tctgtacatc      240

agccagaact gcatccggca ccacctgttt agagagcagg ccttcgatct gcactatgcc      300

tctgacaaga acctgaagaa tgtgctggcc agcatcaccg gactgatcag gggatacgtg      360

gtgccaagct cccagtgtaa gcggacatcc cccctgctgc tggaggattt tgtggaccag      420

ctgggcaacg gcaatttcga gcagtacgga caggcaggag caagggatag cacctccttc      480

tttagcaaga ccacattcgg cgacacagag tacatctcct atggctctat cagcatcgag      540

cagctgcagt ttatcagcct ggataagaag ttcgaccgcg ccgccatggt catcaaggag      600

ggagagggag aagtgatcgc agcagagctg cagaattaca tccagagcct gaacccctcc      660

ctgaatcctc aggccatctt tcactctaac tatgtgcgga gaggcaccat cttcgaggag      720

ggcgagtgcg gcatcctgct gaatgacgat gcagtgaagg ccctggtggc agagaccctg      780

gagagactgg ccaacctgtc catcaggcag gccaagggct acatgtatgt ggacgatatc      840

acagtggatt acaatgactc tcacaagatg atgcggatca agagagatga gagcgagatc      900

atcaacgagc agcacgcccc ttttgcccag tacttctatg caaagtaa                   948


<210>  326
<211>  1011
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(1011)
<223>  Cas5

<400>  326
atgaagatca tcatcgagta cgactcctgc tggagaaacg ccttcctggg cggctctaac       60

aatgagcctg tgccaaagaa gggcagggag tttctgggca gcatgacatc cctgaagaag      120

gagggcaact tcaaggtgtg cgagaatacc ctggatacag tgatgggcgt gctgaacagg      180

ctgatcggcg accagaggaa gctgtaccag gcacggtcca agatgtatga gtctgcctac      240

tattttgagg ccctggagga taaggtgagc ttcatcgaca agccccagct gaccaatgag      300

atctccttta tcagaaacat gaatggctct accgatcaga acgccttcac aggcatgatc      360

aaggtgagcg accccgtgtt cacctctgag tacagccagc agttctgggg cgtgctggcc      420

ctggacttca cccagctgtg cgacttcatc atcaagcaga gccaggtggt gggctccatc      480

gagctgaacc ccctgtctat catcaatagg ctggagagcc tgaaccagga gaaggccctg      540

gagaatagcg acgatctggc ccaggtgctg aaggtgctga acgagtactt tccagacatc      600

gagtatctga acaataaggg cctgatcacc cccatcagca tctactgttc cgccctgtat      660

ctgcagctgg cccgcctgga gacctccttc aatatgacca cagccaagac aaaggccggc      720

ggcatctccg gcatctctaa gagaggcttt accaagaagg atttcatgga caggtacacc      780

acaggcccca agaagacaat ctggggcaac ccttttatca agaaggagaa gatcaagggc      840

cagggcgagg tgacctctat gatgacaaag gccagcggcc agctggagat ctccatcgac      900

gtggatcggg acaaggccca ggagatcaag atcctgatcg agaatgccgg cgtgtcctct      960

ttctacctgg gcaagaaggg cctggcctat gtgagcaaca tcaagctgta a              1011


<210>  327
<211>  552
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(552)
<223>  Cas6

<400>  327
atgaacagct atatcgatat ccgcctgaag ccagacgcag agatgaggga ggcagagctg       60

tctagcaagg tgtttaccaa gttccacaag gccctggtga cactgaactc ccacaagatc      120

ggcatctctt ttccacagat gaagctgtcc ctgggccagc tgttcagaat ccacggcgat      180

gcctctctgc tgcacgatct gcagggcctg gactggctgg gacctctggc cggatactgc      240

caggtgaccg ccgtgagcgc cgtgccagac cacgtgcagt ataggatcgt gtccgtgaag      300

cggagcaatc tgagcaaggc caagctgaag aggctgatcg cccgcggcag catcgacaag      360

gatggcgaga agcggtacaa ggtgaagatg ctgggccagg gctttgataa cccatacctg      420

gacctgttct cctctagcac cggccaggtg tatagaaagt tctttgagtt ttccgatatc      480

caggcccacc cactggatgg cgagttcgac tcctatggcc tgtctaagac cgcaacagtg      540

ccatggttct aa                                                          552


<210>  328
<211>  315
<212>  PRT
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(315)
<223>  Cas7

<400>  328

Met Gln Lys Val Thr Gly Ile Lys Ser Val Asp Phe Lys Ile Lys Ala 
1               5                   10                  15      


Leu Gly His Gly Val Val Asn Trp Asn Gly Pro Thr Thr Leu Thr Gly 
            20                  25                  30          


Asp Asp Gly Lys Thr Val Asp Asn His Thr Leu Pro Lys Leu Arg Gly 
        35                  40                  45              


Tyr Thr Asn Leu Thr Gly Lys Val Lys Asp Glu Thr Gly Tyr Lys Tyr 
    50                  55                  60                  


Lys Lys Gln Ala Thr Asp Ile Asn Phe Lys Glu Thr Pro Leu Tyr Ile 
65                  70                  75                  80  


Ser Gln Asn Cys Ile Arg His His Leu Phe Arg Glu Gln Ala Phe Asp 
                85                  90                  95      


Leu His Tyr Ala Ser Asp Lys Asn Leu Lys Asn Val Leu Ala Ser Ile 
            100                 105                 110         


Thr Gly Leu Ile Arg Gly Tyr Val Val Pro Ser Ser Gln Cys Lys Arg 
        115                 120                 125             


Thr Ser Pro Leu Leu Leu Glu Asp Phe Val Asp Gln Leu Gly Asn Gly 
    130                 135                 140                 


Asn Phe Glu Gln Tyr Gly Gln Ala Gly Ala Arg Asp Ser Thr Ser Phe 
145                 150                 155                 160 


Phe Ser Lys Thr Thr Phe Gly Asp Thr Glu Tyr Ile Ser Tyr Gly Ser 
                165                 170                 175     


Ile Ser Ile Glu Gln Leu Gln Phe Ile Ser Leu Asp Lys Lys Phe Asp 
            180                 185                 190         


Arg Ala Ala Met Val Ile Lys Glu Gly Glu Gly Glu Val Ile Ala Ala 
        195                 200                 205             


Glu Leu Gln Asn Tyr Ile Gln Ser Leu Asn Pro Ser Leu Asn Pro Gln 
    210                 215                 220                 


Ala Ile Phe His Ser Asn Tyr Val Arg Arg Gly Thr Ile Phe Glu Glu 
225                 230                 235                 240 


Gly Glu Cys Gly Ile Leu Leu Asn Asp Asp Ala Val Lys Ala Leu Val 
                245                 250                 255     


Ala Glu Thr Leu Glu Arg Leu Ala Asn Leu Ser Ile Arg Gln Ala Lys 
            260                 265                 270         


Gly Tyr Met Tyr Val Asp Asp Ile Thr Val Asp Tyr Asn Asp Ser His 
        275                 280                 285             


Lys Met Met Arg Ile Lys Arg Asp Glu Ser Glu Ile Ile Asn Glu Gln 
    290                 295                 300                 


His Ala Pro Phe Ala Gln Tyr Phe Tyr Ala Lys 
305                 310                 315 


<210>  329
<211>  336
<212>  PRT
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(336)
<223>  Cas5

<400>  329

Met Lys Ile Ile Ile Glu Tyr Asp Ser Cys Trp Arg Asn Ala Phe Leu 
1               5                   10                  15      


Gly Gly Ser Asn Asn Glu Pro Val Pro Lys Lys Gly Arg Glu Phe Leu 
            20                  25                  30          


Gly Ser Met Thr Ser Leu Lys Lys Glu Gly Asn Phe Lys Val Cys Glu 
        35                  40                  45              


Asn Thr Leu Asp Thr Val Met Gly Val Leu Asn Arg Leu Ile Gly Asp 
    50                  55                  60                  


Gln Arg Lys Leu Tyr Gln Ala Arg Ser Lys Met Tyr Glu Ser Ala Tyr 
65                  70                  75                  80  


Tyr Phe Glu Ala Leu Glu Asp Lys Val Ser Phe Ile Asp Lys Pro Gln 
                85                  90                  95      


Leu Thr Asn Glu Ile Ser Phe Ile Arg Asn Met Asn Gly Ser Thr Asp 
            100                 105                 110         


Gln Asn Ala Phe Thr Gly Met Ile Lys Val Ser Asp Pro Val Phe Thr 
        115                 120                 125             


Ser Glu Tyr Ser Gln Gln Phe Trp Gly Val Leu Ala Leu Asp Phe Thr 
    130                 135                 140                 


Gln Leu Cys Asp Phe Ile Ile Lys Gln Ser Gln Val Val Gly Ser Ile 
145                 150                 155                 160 


Glu Leu Asn Pro Leu Ser Ile Ile Asn Arg Leu Glu Ser Leu Asn Gln 
                165                 170                 175     


Glu Lys Ala Leu Glu Asn Ser Asp Asp Leu Ala Gln Val Leu Lys Val 
            180                 185                 190         


Leu Asn Glu Tyr Phe Pro Asp Ile Glu Tyr Leu Asn Asn Lys Gly Leu 
        195                 200                 205             


Ile Thr Pro Ile Ser Ile Tyr Cys Ser Ala Leu Tyr Leu Gln Leu Ala 
    210                 215                 220                 


Arg Leu Glu Thr Ser Phe Asn Met Thr Thr Ala Lys Thr Lys Ala Gly 
225                 230                 235                 240 


Gly Ile Ser Gly Ile Ser Lys Arg Gly Phe Thr Lys Lys Asp Phe Met 
                245                 250                 255     


Asp Arg Tyr Thr Thr Gly Pro Lys Lys Thr Ile Trp Gly Asn Pro Phe 
            260                 265                 270         


Ile Lys Lys Glu Lys Ile Lys Gly Gln Gly Glu Val Thr Ser Met Met 
        275                 280                 285             


Thr Lys Ala Ser Gly Gln Leu Glu Ile Ser Ile Asp Val Asp Arg Asp 
    290                 295                 300                 


Lys Ala Gln Glu Ile Lys Ile Leu Ile Glu Asn Ala Gly Val Ser Ser 
305                 310                 315                 320 


Phe Tyr Leu Gly Lys Lys Gly Leu Ala Tyr Val Ser Asn Ile Lys Leu 
                325                 330                 335     


<210>  330
<211>  183
<212>  PRT
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(183)
<223>  Cas6

<400>  330

Met Asn Ser Tyr Ile Asp Ile Arg Leu Lys Pro Asp Ala Glu Met Arg 
1               5                   10                  15      


Glu Ala Glu Leu Ser Ser Lys Val Phe Thr Lys Phe His Lys Ala Leu 
            20                  25                  30          


Val Thr Leu Asn Ser His Lys Ile Gly Ile Ser Phe Pro Gln Met Lys 
        35                  40                  45              


Leu Ser Leu Gly Gln Leu Phe Arg Ile His Gly Asp Ala Ser Leu Leu 
    50                  55                  60                  


His Asp Leu Gln Gly Leu Asp Trp Leu Gly Pro Leu Ala Gly Tyr Cys 
65                  70                  75                  80  


Gln Val Thr Ala Val Ser Ala Val Pro Asp His Val Gln Tyr Arg Ile 
                85                  90                  95      


Val Ser Val Lys Arg Ser Asn Leu Ser Lys Ala Lys Leu Lys Arg Leu 
            100                 105                 110         


Ile Ala Arg Gly Ser Ile Asp Lys Asp Gly Glu Lys Arg Tyr Lys Val 
        115                 120                 125             


Lys Met Leu Gly Gln Gly Phe Asp Asn Pro Tyr Leu Asp Leu Phe Ser 
    130                 135                 140                 


Ser Ser Thr Gly Gln Val Tyr Arg Lys Phe Phe Glu Phe Ser Asp Ile 
145                 150                 155                 160 


Gln Ala His Pro Leu Asp Gly Glu Phe Asp Ser Tyr Gly Leu Ser Lys 
                165                 170                 175     


Thr Ala Thr Val Pro Trp Phe 
            180             


<210>  331
<211>  88
<212>  DNA
<213>  Shewanella putrefaciens CN-32


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  CRISPR

<400>  331
gttcaccgcc gcacaggcgg cttagaaatc aaccaaatca taaattgcgc gaccacattg       60

gttcaccgcc gcacaggcgg cttagaaa                                          88


<210>  332
<211>  990
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(990)
<223>  Cas7

<400>  332
atggctaaag taacaggcgt aaaaagcgta gattttaaaa ttacagcata tggttatggg       60

gtggtgaatt ggaatggtcc aacgtcactg acaggtaatg atggtaagac agtggataac      120

cacacattac ctaaacttcg tggtttcagt aatttatcag gtagagtcaa agaagaaaca      180

ggctacaaat accgtaaaga agcatcagac attgatttta acgaaacgcc tttatatatc      240

agccaaaatt gtattcgcca tcacttattc cgtgaccaat cttttgattt acattatgca      300

aaagataaga atttgattga tgttctagca tctattacgg gattaatccg tggttatgtt      360

gtgccatcga gtcaatgtaa acgtacaagt ccacttttga ttactgattt tattgatcag      420

ttgggtaatg gcaactttga acagctttcg aatgcaagtt caagtgaaga aattacgcaa      480

gatgatggct caaaaacata taaacgtggt gaaaactcaa tcttctctaa aacgaccttt      540

ggtgataccg aatatatcgc ttatggctcg attagtattg aacaattgca gttcatttca      600

ctcgataaaa aatttgaccg tgcttcgatg attattaaag aaggagaagg tgaaaagatt      660

gcagagcgag tacaggaatt tattaagagc cttgatccat cgaaagaacc aaaagcaatt      720

ttccataaaa attatgtccg taagggaaca atctttaatg aaggtgaagt gggtatttta      780

ctcgacaaca ctgcaattga tattttagtc aaagaaacgc tttcaatgct tgaagaactc      840

gttattaagc aagccaaagg ttatatgtgc gcagatacgg tagaagtgga ttataacgac      900

agtcataaaa tgatgcgtat taaacgcaat ccagaccaag ccaatcctga gctacaacaa      960

gattatgcag tttattttga agcccaataa                                       990


<210>  333
<211>  1014
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(1014)
<223>  Cas5

<400>  333
atgcaaatca ttattgaata tgaatcctct tggcgaaatt catttttaga tggctctaat       60

aatgaaccct tgcctaaagg cggacgtaat tttattgctt caatgacaac attaaagcaa      120

gaaggcaatt acaaaaagcg tagtatttca aaagataccg tcatgggcat tctaaatcgt      180

ttgattggtg atcaacgtaa actttatcag gcacgacagg atgaaaatta ttattttact      240

gaagttgaaa aagtacttca ggagaatgat attgtcgatc acgctttaaa tagtaacgag      300

atggtttata tccgtaatgt ttcagggagt acagatcaaa attcatttac aggtgaaatt      360

aaagcaaatg atccatcctt tagctcgagt ttttcagctg aactttgggg tgttttatgg      420

cttaatttat ctgaagtttc caaatttatt ttggatgagt catattctgt gacctactct      480

gaagttttag atccaattac ggtgtgtaat cgtattgaag ttttgagtgc agaaaaacca      540

atggatctga cggaggatat tcaagctgta ctagactatt tattgaatca tttccccgat      600

acaaagtatt tgactgcaaa aaagcaatta cctttgatca gtatttatgc ctctgcttta      660

tatcttcaaa ttacaagatt atctcaaaga tatgatctct caactgtctt aacaaaaagt      720

ggcggactga gtggaatctc aaagcgtgga tttaccaaaa aagattttat ggatcgttat      780

acgacaggaa gtaaaaagct catttggggc aatccctatt tattgaaaga aaagaaaaaa      840

ggtgagggtg aaatcgtatc tgttttaacc aaagctagtg gaaagctcat tataaatttg      900

aatatttcta aagaacaagc aagagattta gaagaaaaaa ttgaaaatgc aggggtttca      960

tctttttact taggtaaaaa gggcttggct tatgtcacgg atattagacc ttaa           1014


<210>  334
<211>  603
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(603)
<223>  Cas6

<400>  334
atgaactatt acattgaagt aacattaatg gaaaatgatc aattttctcc ttatgaatta       60

tggtcacaac tttatcctca attgcatctt gcattggttg aagccaaaaa tgctgacaat      120

aaagtgaata ttggattttc gttccctcaa taccgctttc atcaagataa aggtgttgga      180

tttataggta caaaattacg tttatttgct gagtctgaag ctgatttgaa gaaactggac      240

attcgacgtt ggcttgagcg tttagaagat tatgtacatg tcacttctat tcgtgaagta      300

cctaatgata ttaagaacta tgccatttat aagcgtaagc aagtgaaaac caatgcacaa      360

cgtttggcgc gtcaccgtgt aaaacgtggg gatattggct ttgatgaggc attagccaga      420

tacagcaatg tagttacgac aaccaacatg ccttatattg aaatgaaaag cctgagcact      480

tcagatcagc aaagtgaaaa acgttttaaa ttgtttatcg aaaagcaatc tgctgaaaaa      540

tctgaaactc aggtttttag cacttatgga ttaagttcgg tgtcatctgt accagaattt      600

taa                                                                    603


<210>  335
<211>  990
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(990)
<223>  Cas7

<400>  335
atggccaagg tgacaggcgt gaagtccgtg gacttcaaga tcaccgccta cggctatggc       60

gtggtgaact ggaatggccc aacaagcctg accggcaatg acggcaagac agtggataac      120

cacaccctgc ccaagctgag aggcttctcc aatctgtctg gcagggtgaa ggaggagaca      180

ggctacaagt ataggaagga ggcctctgac atcgacttca acgagacccc tctgtacatc      240

agccagaact gcatcaggca ccacctgttt cgcgaccagt ccttcgatct gcactatgcc      300

aaggacaaga acctgatcga tgtgctggcc tctatcaccg gactgatcag gggatacgtg      360

gtgccaagct cccagtgtaa gcggacaagc cccctgctga tcaccgactt catcgatcag      420

ctgggcaacg gcaattttga gcagctgagc aatgcctcta gctccgagga gatcacacag      480

gacgatggct ccaagaccta caagcgcggc gagaacagca tcttttccaa gaccacattc      540

ggcgacaccg agtacatcgc ctatggctcc atctctatcg agcagctgca gtttatctcc      600

ctggacaaga agttcgatag agcctctatg atcatcaagg agggcgaggg cgagaagatc      660

gccgagaggg tgcaggagtt catcaagagc ctggacccca gcaaggagcc taaggccatc      720

ttccacaaga attacgtgcg gaagggcaca atctttaacg agggcgaagt gggcatcctg      780

ctggacaata cagccatcga tatcctggtg aaggagaccc tgagcatgct ggaggagctg      840

gtcatcaagc aggccaaggg ctacatgtgc gccgacaccg tggaggtgga ctataacgat      900

tcccacaaga tgatgaggat caagcgcaat ccagaccagg ccaaccccga gctgcagcag      960

gattacgccg tgtatttcga ggcacagtaa                                       990


<210>  336
<211>  1014
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(1014)
<223>  Cas5

<400>  336
atgcagatca tcatcgagta cgagagctcc tggcgcaact ccttcctgga cggctctaac       60

aatgagcctc tgccaaaggg cggccggaac ttcatcgcct ccatgacaac cctgaagcag      120

gagggcaact acaagaagcg gagcatctct aaggatacag tgatgggcat cctgaacagg      180

ctgatcggcg accagcgcaa gctgtatcag gcccggcagg atgagaatta ctatttcacc      240

gaggtggaga aggtgctgca ggagaacgac atcgtggatc acgccctgaa cagcaatgag      300

atggtgtaca tcagaaacgt gagcggcagc acagaccaga actccttcac cggagagatc      360

aaggccaatg atcccagctt ttctagctcc ttctccgccg agctgtgggg cgtgctgtgg      420

ctgaacctgt ccgaggtgtc taagtttatc ctggacgagt cttacagcgt gacatattct      480

gaggtgctgg accccatcac cgtgtgcaat cggatcgagg tgctgagcgc cgagaagcct      540

atggacctga ccgaggatat ccaggccgtg ctggactacc tgctgaacca ctttccagat      600

acaaagtatc tgaccgccaa gaagcagctg cccctgatca gcatctacgc ctccgccctg      660

tatctgcaga tcacacggct gtctcagaga tacgacctga gcacagtgct gaccaagtcc      720

ggcggactga gcggcatctc caagagaggc tttaccaaga aggacttcat ggataggtac      780

acaaccggca gcaagaagct gatctggggc aatccttatc tgctgaagga gaagaagaag      840

ggcgagggcg agatcgtgtc tgtgctgaca aaggccagcg gcaagctgat catcaacctg      900

aatatctcca aggagcaggc cagagacctg gaggagaaga tcgagaacgc cggcgtgtct      960

agcttctacc tgggcaagaa gggcctggcc tatgtgaccg atatcaggcc ataa           1014


<210>  337
<211>  603
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(603)
<223>  Cas6

<400>  337
atgaattact atatcgaggt gaccctgatg gagaacgatc agttttctcc ttacgagctg       60

tggagccagc tgtatccaca gctgcacctg gccctggtgg aggcaaagaa cgccgacaat      120

aaggtgaaca tcggcttctc ctttccccag taccgctttc accaggataa gggcgtgggc      180

ttcatcggca ccaagctgcg gctgtttgcc gagtccgagg ccgacctgaa gaagctggat      240

atccggcggt ggctggagag actggaggac tatgtgcacg tgacatctat cagggaggtg      300

cccaatgata tcaagaacta cgccatctat aagaggaagc aggtgaagac caacgcacag      360

cgcctggcca ggcacagagt gaagcggggc gacatcggct tcgatgaggc cctggcccgc      420

tacagcaatg tggtgaccac aaccaacatg ccttatatcg agatgaagag cctgtccaca      480

tctgaccagc agtctgagaa gcggtttaag ctgttcatcg agaagcagtc cgccgagaag      540

tctgagacac aggtgttcag cacctacggc ctgtctagcg tgtcctctgt gcctgagttt      600

taa                                                                    603


<210>  338
<211>  329
<212>  PRT
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(329)
<223>  Cas7

<400>  338

Met Ala Lys Val Thr Gly Val Lys Ser Val Asp Phe Lys Ile Thr Ala 
1               5                   10                  15      


Tyr Gly Tyr Gly Val Val Asn Trp Asn Gly Pro Thr Ser Leu Thr Gly 
            20                  25                  30          


Asn Asp Gly Lys Thr Val Asp Asn His Thr Leu Pro Lys Leu Arg Gly 
        35                  40                  45              


Phe Ser Asn Leu Ser Gly Arg Val Lys Glu Glu Thr Gly Tyr Lys Tyr 
    50                  55                  60                  


Arg Lys Glu Ala Ser Asp Ile Asp Phe Asn Glu Thr Pro Leu Tyr Ile 
65                  70                  75                  80  


Ser Gln Asn Cys Ile Arg His His Leu Phe Arg Asp Gln Ser Phe Asp 
                85                  90                  95      


Leu His Tyr Ala Lys Asp Lys Asn Leu Ile Asp Val Leu Ala Ser Ile 
            100                 105                 110         


Thr Gly Leu Ile Arg Gly Tyr Val Val Pro Ser Ser Gln Cys Lys Arg 
        115                 120                 125             


Thr Ser Pro Leu Leu Ile Thr Asp Phe Ile Asp Gln Leu Gly Asn Gly 
    130                 135                 140                 


Asn Phe Glu Gln Leu Ser Asn Ala Ser Ser Ser Glu Glu Ile Thr Gln 
145                 150                 155                 160 


Asp Asp Gly Ser Lys Thr Tyr Lys Arg Gly Glu Asn Ser Ile Phe Ser 
                165                 170                 175     


Lys Thr Thr Phe Gly Asp Thr Glu Tyr Ile Ala Tyr Gly Ser Ile Ser 
            180                 185                 190         


Ile Glu Gln Leu Gln Phe Ile Ser Leu Asp Lys Lys Phe Asp Arg Ala 
        195                 200                 205             


Ser Met Ile Ile Lys Glu Gly Glu Gly Glu Lys Ile Ala Glu Arg Val 
    210                 215                 220                 


Gln Glu Phe Ile Lys Ser Leu Asp Pro Ser Lys Glu Pro Lys Ala Ile 
225                 230                 235                 240 


Phe His Lys Asn Tyr Val Arg Lys Gly Thr Ile Phe Asn Glu Gly Glu 
                245                 250                 255     


Val Gly Ile Leu Leu Asp Asn Thr Ala Ile Asp Ile Leu Val Lys Glu 
            260                 265                 270         


Thr Leu Ser Met Leu Glu Glu Leu Val Ile Lys Gln Ala Lys Gly Tyr 
        275                 280                 285             


Met Cys Ala Asp Thr Val Glu Val Asp Tyr Asn Asp Ser His Lys Met 
    290                 295                 300                 


Met Arg Ile Lys Arg Asn Pro Asp Gln Ala Asn Pro Glu Leu Gln Gln 
305                 310                 315                 320 


Asp Tyr Ala Val Tyr Phe Glu Ala Gln 
                325                 


<210>  339
<211>  337
<212>  PRT
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(337)
<223>  Cas5

<400>  339

Met Gln Ile Ile Ile Glu Tyr Glu Ser Ser Trp Arg Asn Ser Phe Leu 
1               5                   10                  15      


Asp Gly Ser Asn Asn Glu Pro Leu Pro Lys Gly Gly Arg Asn Phe Ile 
            20                  25                  30          


Ala Ser Met Thr Thr Leu Lys Gln Glu Gly Asn Tyr Lys Lys Arg Ser 
        35                  40                  45              


Ile Ser Lys Asp Thr Val Met Gly Ile Leu Asn Arg Leu Ile Gly Asp 
    50                  55                  60                  


Gln Arg Lys Leu Tyr Gln Ala Arg Gln Asp Glu Asn Tyr Tyr Phe Thr 
65                  70                  75                  80  


Glu Val Glu Lys Val Leu Gln Glu Asn Asp Ile Val Asp His Ala Leu 
                85                  90                  95      


Asn Ser Asn Glu Met Val Tyr Ile Arg Asn Val Ser Gly Ser Thr Asp 
            100                 105                 110         


Gln Asn Ser Phe Thr Gly Glu Ile Lys Ala Asn Asp Pro Ser Phe Ser 
        115                 120                 125             


Ser Ser Phe Ser Ala Glu Leu Trp Gly Val Leu Trp Leu Asn Leu Ser 
    130                 135                 140                 


Glu Val Ser Lys Phe Ile Leu Asp Glu Ser Tyr Ser Val Thr Tyr Ser 
145                 150                 155                 160 


Glu Val Leu Asp Pro Ile Thr Val Cys Asn Arg Ile Glu Val Leu Ser 
                165                 170                 175     


Ala Glu Lys Pro Met Asp Leu Thr Glu Asp Ile Gln Ala Val Leu Asp 
            180                 185                 190         


Tyr Leu Leu Asn His Phe Pro Asp Thr Lys Tyr Leu Thr Ala Lys Lys 
        195                 200                 205             


Gln Leu Pro Leu Ile Ser Ile Tyr Ala Ser Ala Leu Tyr Leu Gln Ile 
    210                 215                 220                 


Thr Arg Leu Ser Gln Arg Tyr Asp Leu Ser Thr Val Leu Thr Lys Ser 
225                 230                 235                 240 


Gly Gly Leu Ser Gly Ile Ser Lys Arg Gly Phe Thr Lys Lys Asp Phe 
                245                 250                 255     


Met Asp Arg Tyr Thr Thr Gly Ser Lys Lys Leu Ile Trp Gly Asn Pro 
            260                 265                 270         


Tyr Leu Leu Lys Glu Lys Lys Lys Gly Glu Gly Glu Ile Val Ser Val 
        275                 280                 285             


Leu Thr Lys Ala Ser Gly Lys Leu Ile Ile Asn Leu Asn Ile Ser Lys 
    290                 295                 300                 


Glu Gln Ala Arg Asp Leu Glu Glu Lys Ile Glu Asn Ala Gly Val Ser 
305                 310                 315                 320 


Ser Phe Tyr Leu Gly Lys Lys Gly Leu Ala Tyr Val Thr Asp Ile Arg 
                325                 330                 335     


Pro 
    


<210>  340
<211>  200
<212>  PRT
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  Cas6

<400>  340

Met Asn Tyr Tyr Ile Glu Val Thr Leu Met Glu Asn Asp Gln Phe Ser 
1               5                   10                  15      


Pro Tyr Glu Leu Trp Ser Gln Leu Tyr Pro Gln Leu His Leu Ala Leu 
            20                  25                  30          


Val Glu Ala Lys Asn Ala Asp Asn Lys Val Asn Ile Gly Phe Ser Phe 
        35                  40                  45              


Pro Gln Tyr Arg Phe His Gln Asp Lys Gly Val Gly Phe Ile Gly Thr 
    50                  55                  60                  


Lys Leu Arg Leu Phe Ala Glu Ser Glu Ala Asp Leu Lys Lys Leu Asp 
65                  70                  75                  80  


Ile Arg Arg Trp Leu Glu Arg Leu Glu Asp Tyr Val His Val Thr Ser 
                85                  90                  95      


Ile Arg Glu Val Pro Asn Asp Ile Lys Asn Tyr Ala Ile Tyr Lys Arg 
            100                 105                 110         


Lys Gln Val Lys Thr Asn Ala Gln Arg Leu Ala Arg His Arg Val Lys 
        115                 120                 125             


Arg Gly Asp Ile Gly Phe Asp Glu Ala Leu Ala Arg Tyr Ser Asn Val 
    130                 135                 140                 


Val Thr Thr Thr Asn Met Pro Tyr Ile Glu Met Lys Ser Leu Ser Thr 
145                 150                 155                 160 


Ser Asp Gln Gln Ser Glu Lys Arg Phe Lys Leu Phe Ile Glu Lys Gln 
                165                 170                 175     


Ser Ala Glu Lys Ser Glu Thr Gln Val Phe Ser Thr Tyr Gly Leu Ser 
            180                 185                 190         


Ser Val Ser Ser Val Pro Glu Phe 
        195                 200 


<210>  341
<211>  88
<212>  DNA
<213>  Acinetobacter sp. 869535


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  CRISPR

<400>  341
gttcactgcc atataggcag cttagaaaat cgttttttca tacgagattc gaaacggaca       60

gttcactgcc atataggcag cttagaaa                                          88


<210>  342
<211>  948
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(948)
<223>  Cas7

<400>  342
atgcaaaaag taacaggaat taaaagtgta gattttaaaa ttaaagcatt aggtcatggt       60

gtagtgaatt ggaatgggcc tacaacctta actggagatg atggtaaaac agtcgataat      120

cataccttgc caaaattgcg cggctatacc aacttaaccg gtaaagtgaa agatgaaact      180

ggctataaat ataaaaaaca agcaactgac attaatttca aagaaacacc actgtatata      240

agtcaaaatt gtattcgaca tcatttgttt cgtgagcaag cttttgattt acattttgct      300

agtgacaaaa acctaaaaaa cgttctggct tcaattacgg ggttgatccg aggttatgta      360

gttcctgcaa gtcaatgtaa gcgcaccagt ccactattgt tagaagattt tgttgatcaa      420

ttggggaatg gcaactttga acaatatgga caggcaggtg ctagagatag cacatcattt      480

ttttcaaaga ctacttttgg tgatactgaa tatatctctt atggttccat cagtattgaa      540

caactgcaat ttatatcgtt ggataagaag tttgatcgtg ccgcaatggt tatcaaagag      600

ggcgagggtg aggttattgc cgctgaacta caaagctata ttaagtcact taatcctagc      660

ttaaacccac aggcgatttt tcacaaaaac tacgtcagaa gaggcacaat atttgaagag      720

ggagagtgtg gcattttact taatgatgac gcagtgaaag ctttagttga cgaaacacta      780

gatcgtttag ctaatttgtc tattcgtcaa gcgaaaggtt atatgtatgt tgacgaaatt      840

acagttgatt ataacgatag tcataaaatg atgcgcatta agcgtgatga atcagaaatt      900

tcagagcaac ctaatagcaa ttttgcaatt tacttttatg caaagtag                   948


<210>  343
<211>  1056
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(1056)
<223>  Cas5

<400>  343
atgaaaatct taattgatta tgaagcatct tggcgtaatt catttttgga tggtaataat       60

gatgaaccat tacccgcgaa aggtagaaca tttatagctg caagctccag tttaaatgat      120

cgtgaaaagc cggataattt taaattagtt gacgtaacga agcagactgt atttggaatc      180

ctgtgtcgat tgatcggtga tcaaaggaaa ttataccaat caaagcaaag tgatacatat      240

ttcctgaaag ggttggaaga ctttataacg ttcaaagata tacctgtgtt gaccaatgaa      300

attgtatata ttcggaatat gactggcagc tttgacagag agtcatatac tggagtgata      360

aatacaaatc attggttgtt taaatctgtt ttttctaatc aactttggag tcttgctttt      420

actgatctaa atgcactggt cagttttata gttgaagaga ttgaagttgc taatgatcaa      480

gagttcgatc ctagggatgt tattgatcga tttaataaat ttaaaagtat tggtatcagt      540

aaaattgatg aattaggctt gtcagaaaat cgtttatata aggctgttga cattctttat      600

gatgctaacc ttaatgcaaa tgtaaggtct ttgtttccca gtatgaaaaa gagcttttct      660

gatattgatt atattaaatc agataaagtt gatgtcagag cattatattg ctctgcacta      720

tatttaaaat tagtcaggct taatctcggt ggtataccta taccgagtaa tattaaaggg      780

ttttctgtgg ctggtttgac accaaaagac tttatgggca gtttcacaca aggtaaaaag      840

aaggtttacg gtaatcctta tctaaaaaag gaaatgataa aagggcaagg agaagtgaca      900

tctatgctga ccaaagccag tgggcagttg gaaattacta ttgacgtgga tcgagacaaa      960

gcacaagaaa tcaaaacgtt gattgaaaat gctggggtat caagctttta ccttggaaaa     1020

aaagggctgg cttacgtttc aagcattcga ctttag                               1056


<210>  344
<211>  552
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(552)
<223>  Cas6

<400>  344
atggacgcat acattgatat acggctgatg cctgatgctg aaatgcgcga ggcagaatta       60

agtagtaaag tctttattaa attccacaaa gcactggtga agttacagag caataaaatt      120

ggtattagct ttccagaagc aaatattaag ctagggcgat tatttcgttt acacggtgaa      180

gtgagcgcat tgcatgattt gcaggggtta aattggttag gacctttggc aggatattgc      240

aagattacta cggttactca tgtgccagac caagtggaat atcgcatcat ttcagttaaa      300

cgcagcaatt taagcaaagc aaaattagcg cgtttaattg ctagaggtag catagataaa      360

gatggtgaga aacgttacaa agtaaaaatg cttcgccaag ggtttgataa tccatacctt      420

gatctgtcta gcagttcaac agggcaggtg taccgaaaat tctttgagtt tagtgatatt      480

caagctgagc cagttgatgg tgagtttgat agttatggtc taagcaaaac agcaactgta      540

ccttggtttt aa                                                          552


<210>  345
<211>  948
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(948)
<223>  Cas7

<400>  345
atgcagaagg tgaccggcat caagtccgtg gacttcaaga tcaaggccct gggccacggc       60

gtggtgaact ggaatggccc taccacactg acaggcgacg atggcaagac cgtggataat      120

cacacactgc caaagctgag gggctatacc aacctgacag gcaaggtgaa ggacgagacc      180

ggctacaagt ataagaagca ggccaccgat atcaacttca aggagacacc tctgtacatc      240

agccagaact gcatcaggca ccacctgttc cgcgagcagg cctttgacct gcacttcgcc      300

tctgataaga atctgaagaa cgtgctggcc agcatcaccg gactgatcag gggctatgtg      360

gtgccagcca gccagtgtaa gagaacatcc cccctgctgc tggaggattt tgtggaccag      420

ctgggcaacg gcaatttcga gcagtacgga caggcaggag caagggactc cacctctttc      480

ttttccaaga ccacattcgg cgatacagag tacatctctt atggcagcat ctccatcgag      540

cagctgcagt ttatcagcct ggacaagaag ttcgatcggg ccgccatggt catcaaggag      600

ggagagggag aagtgatcgc agcagagctg cagagctaca tcaagtccct gaatccatct      660

ctgaaccccc aggccatctt tcacaagaac tatgtgcgga gaggcaccat cttcgaggag      720

ggcgagtgcg gcatcctgct gaatgacgat gccgtgaagg ccctggtgga cgagaccctg      780

gatcggctgg ccaacctgtc catcagacag gccaagggct acatgtatgt ggacgagatc      840

acagtggatt acaatgacag ccacaagatg atgcggatca agagagatga gtctgagatc      900

agcgagcagc caaactccaa ttttgccatc tacttctatg caaagtaa                   948


<210>  346
<211>  1056
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(1056)
<223>  Cas5

<400>  346
atgaagatcc tgatcgacta cgaggcctct tggagaaaca gctttctgga cggcaacaat       60

gatgagcctc tgccagccaa gggcaggaca ttcatcgccg ccagctcctc tctgaatgac      120

cgcgagaagc cagataactt taagctggtg gatgtgacca agcagacagt gttcggcatc      180

ctgtgcaggc tgatcggcga ccagcgcaag ctgtaccagt ctaagcagag cgatacctat      240

tttctgaagg gcctggagga ctttatcacc ttcaaggata tccccgtgct gacaaatgag      300

atcgtgtaca tcaggaacat gacaggctcc ttcgaccgcg agtcttatac cggcgtgatc      360

aacacaaatc actggctgtt taagtccgtg ttctctaatc agctgtggag cctggccttt      420

accgacctga acgccctggt gtccttcatc gtggaggaga tcgaggtggc caatgatcag      480

gagttcgatc cccgggacgt gatcgatcgg ttcaacaagt tcaagtccat cggcatctct      540

aagatcgacg agctgggcct gagcgagaac aggctgtaca aggccgtgga catcctgtat      600

gatgccaacc tgaatgccaa cgtgcgcagc ctgtttcctt ccatgaagaa gagcttctcc      660

gacatcgatt acatcaagtc tgacaaggtg gatgtgcggg ccctgtactg cagcgccctg      720

tatctgaagc tggtgagact gaatctgggc ggcatcccca tcccttctaa catcaagggc      780

tttagcgtgg ccggcctgac cccaaaggac tttatgggct ccttcacaca gggcaagaag      840

aaggtgtacg gcaatcccta tctgaagaag gagatgatca agggccaggg cgaggtgacc      900

tccatgctga caaaggcctc tggccagctg gagatcacca tcgacgtgga tagagacaag      960

gcccaggaga tcaagacact gatcgagaac gccggcgtga gctccttcta cctgggcaag     1020

aagggcctgg cctacgtgag cagcatcagg ctgtaa                               1056


<210>  347
<211>  552
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(552)
<223>  Cas6

<400>  347
atggacgcct acatcgatat ccggctgatg ccagatgccg agatgagaga ggccgagctg       60

agctccaagg tgtttatcaa gttccacaag gccctggtga agctgcagtc caataagatc      120

ggcatctctt ttcctgaggc caacatcaag ctgggcaggc tgttccgcct gcacggagag      180

gtgtccgccc tgcacgacct gcagggcctg aattggctgg gaccactggc cggctactgc      240

aagatcacca cagtgaccca cgtgcccgat caggtggagt ataggatcat ctctgtgaag      300

cggagcaacc tgtctaaggc aaagctggcc aggctgatcg caagaggctc catcgacaag      360

gatggcgaga agaggtataa ggtgaagatg ctgcgccagg gctttgacaa tccttacctg      420

gatctgtcta gctcctctac cggccaggtg tatcggaagt tctttgagtt tagcgacatc      480

caggcagagc cagtggacgg agagttcgat agctacggcc tgtccaagac cgcaacagtg      540

ccttggttct aa                                                          552


<210>  348
<211>  315
<212>  PRT
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(315)
<223>  Cas7

<400>  348

Met Gln Lys Val Thr Gly Ile Lys Ser Val Asp Phe Lys Ile Lys Ala 
1               5                   10                  15      


Leu Gly His Gly Val Val Asn Trp Asn Gly Pro Thr Thr Leu Thr Gly 
            20                  25                  30          


Asp Asp Gly Lys Thr Val Asp Asn His Thr Leu Pro Lys Leu Arg Gly 
        35                  40                  45              


Tyr Thr Asn Leu Thr Gly Lys Val Lys Asp Glu Thr Gly Tyr Lys Tyr 
    50                  55                  60                  


Lys Lys Gln Ala Thr Asp Ile Asn Phe Lys Glu Thr Pro Leu Tyr Ile 
65                  70                  75                  80  


Ser Gln Asn Cys Ile Arg His His Leu Phe Arg Glu Gln Ala Phe Asp 
                85                  90                  95      


Leu His Phe Ala Ser Asp Lys Asn Leu Lys Asn Val Leu Ala Ser Ile 
            100                 105                 110         


Thr Gly Leu Ile Arg Gly Tyr Val Val Pro Ala Ser Gln Cys Lys Arg 
        115                 120                 125             


Thr Ser Pro Leu Leu Leu Glu Asp Phe Val Asp Gln Leu Gly Asn Gly 
    130                 135                 140                 


Asn Phe Glu Gln Tyr Gly Gln Ala Gly Ala Arg Asp Ser Thr Ser Phe 
145                 150                 155                 160 


Phe Ser Lys Thr Thr Phe Gly Asp Thr Glu Tyr Ile Ser Tyr Gly Ser 
                165                 170                 175     


Ile Ser Ile Glu Gln Leu Gln Phe Ile Ser Leu Asp Lys Lys Phe Asp 
            180                 185                 190         


Arg Ala Ala Met Val Ile Lys Glu Gly Glu Gly Glu Val Ile Ala Ala 
        195                 200                 205             


Glu Leu Gln Ser Tyr Ile Lys Ser Leu Asn Pro Ser Leu Asn Pro Gln 
    210                 215                 220                 


Ala Ile Phe His Lys Asn Tyr Val Arg Arg Gly Thr Ile Phe Glu Glu 
225                 230                 235                 240 


Gly Glu Cys Gly Ile Leu Leu Asn Asp Asp Ala Val Lys Ala Leu Val 
                245                 250                 255     


Asp Glu Thr Leu Asp Arg Leu Ala Asn Leu Ser Ile Arg Gln Ala Lys 
            260                 265                 270         


Gly Tyr Met Tyr Val Asp Glu Ile Thr Val Asp Tyr Asn Asp Ser His 
        275                 280                 285             


Lys Met Met Arg Ile Lys Arg Asp Glu Ser Glu Ile Ser Glu Gln Pro 
    290                 295                 300                 


Asn Ser Asn Phe Ala Ile Tyr Phe Tyr Ala Lys 
305                 310                 315 


<210>  349
<211>  351
<212>  PRT
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(351)
<223>  Cas5

<400>  349

Met Lys Ile Leu Ile Asp Tyr Glu Ala Ser Trp Arg Asn Ser Phe Leu 
1               5                   10                  15      


Asp Gly Asn Asn Asp Glu Pro Leu Pro Ala Lys Gly Arg Thr Phe Ile 
            20                  25                  30          


Ala Ala Ser Ser Ser Leu Asn Asp Arg Glu Lys Pro Asp Asn Phe Lys 
        35                  40                  45              


Leu Val Asp Val Thr Lys Gln Thr Val Phe Gly Ile Leu Cys Arg Leu 
    50                  55                  60                  


Ile Gly Asp Gln Arg Lys Leu Tyr Gln Ser Lys Gln Ser Asp Thr Tyr 
65                  70                  75                  80  


Phe Leu Lys Gly Leu Glu Asp Phe Ile Thr Phe Lys Asp Ile Pro Val 
                85                  90                  95      


Leu Thr Asn Glu Ile Val Tyr Ile Arg Asn Met Thr Gly Ser Phe Asp 
            100                 105                 110         


Arg Glu Ser Tyr Thr Gly Val Ile Asn Thr Asn His Trp Leu Phe Lys 
        115                 120                 125             


Ser Val Phe Ser Asn Gln Leu Trp Ser Leu Ala Phe Thr Asp Leu Asn 
    130                 135                 140                 


Ala Leu Val Ser Phe Ile Val Glu Glu Ile Glu Val Ala Asn Asp Gln 
145                 150                 155                 160 


Glu Phe Asp Pro Arg Asp Val Ile Asp Arg Phe Asn Lys Phe Lys Ser 
                165                 170                 175     


Ile Gly Ile Ser Lys Ile Asp Glu Leu Gly Leu Ser Glu Asn Arg Leu 
            180                 185                 190         


Tyr Lys Ala Val Asp Ile Leu Tyr Asp Ala Asn Leu Asn Ala Asn Val 
        195                 200                 205             


Arg Ser Leu Phe Pro Ser Met Lys Lys Ser Phe Ser Asp Ile Asp Tyr 
    210                 215                 220                 


Ile Lys Ser Asp Lys Val Asp Val Arg Ala Leu Tyr Cys Ser Ala Leu 
225                 230                 235                 240 


Tyr Leu Lys Leu Val Arg Leu Asn Leu Gly Gly Ile Pro Ile Pro Ser 
                245                 250                 255     


Asn Ile Lys Gly Phe Ser Val Ala Gly Leu Thr Pro Lys Asp Phe Met 
            260                 265                 270         


Gly Ser Phe Thr Gln Gly Lys Lys Lys Val Tyr Gly Asn Pro Tyr Leu 
        275                 280                 285             


Lys Lys Glu Met Ile Lys Gly Gln Gly Glu Val Thr Ser Met Leu Thr 
    290                 295                 300                 


Lys Ala Ser Gly Gln Leu Glu Ile Thr Ile Asp Val Asp Arg Asp Lys 
305                 310                 315                 320 


Ala Gln Glu Ile Lys Thr Leu Ile Glu Asn Ala Gly Val Ser Ser Phe 
                325                 330                 335     


Tyr Leu Gly Lys Lys Gly Leu Ala Tyr Val Ser Ser Ile Arg Leu 
            340                 345                 350     


<210>  350
<211>  183
<212>  PRT
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(183)
<223>  Cas6

<400>  350

Met Asp Ala Tyr Ile Asp Ile Arg Leu Met Pro Asp Ala Glu Met Arg 
1               5                   10                  15      


Glu Ala Glu Leu Ser Ser Lys Val Phe Ile Lys Phe His Lys Ala Leu 
            20                  25                  30          


Val Lys Leu Gln Ser Asn Lys Ile Gly Ile Ser Phe Pro Glu Ala Asn 
        35                  40                  45              


Ile Lys Leu Gly Arg Leu Phe Arg Leu His Gly Glu Val Ser Ala Leu 
    50                  55                  60                  


His Asp Leu Gln Gly Leu Asn Trp Leu Gly Pro Leu Ala Gly Tyr Cys 
65                  70                  75                  80  


Lys Ile Thr Thr Val Thr His Val Pro Asp Gln Val Glu Tyr Arg Ile 
                85                  90                  95      


Ile Ser Val Lys Arg Ser Asn Leu Ser Lys Ala Lys Leu Ala Arg Leu 
            100                 105                 110         


Ile Ala Arg Gly Ser Ile Asp Lys Asp Gly Glu Lys Arg Tyr Lys Val 
        115                 120                 125             


Lys Met Leu Arg Gln Gly Phe Asp Asn Pro Tyr Leu Asp Leu Ser Ser 
    130                 135                 140                 


Ser Ser Thr Gly Gln Val Tyr Arg Lys Phe Phe Glu Phe Ser Asp Ile 
145                 150                 155                 160 


Gln Ala Glu Pro Val Asp Gly Glu Phe Asp Ser Tyr Gly Leu Ser Lys 
                165                 170                 175     


Thr Ala Thr Val Pro Trp Phe 
            180             


<210>  351
<211>  88
<212>  DNA
<213>  Vibrio cholerae HE48


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  CRISPR

<400>  351
gttcactgcc gcacaggcag cttagaaata accggaggcg tacactcgat agaggcagcg       60

gttcactgcc gcacaggcag cttagaaa                                          88


<210>  352
<211>  3736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR

<400>  352
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccgccag tgataagtgg aatgccatgt gggctgtcga gttccccgcg ccagcgggga      180

taaaccggag ctcgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt      240

gaggggtttt ttgctgaaac ctcaggcatt tgagaagcac acggtcacac tgcttccggt      300

agtcaataaa ccggtaaacc agcaatagac ataagcggct atttaacgac cctgccctga      360

accgacgacc gggtcgaatt tgctttcgaa tttctgccat tcatccgctt attatcactt      420

attcaggcgt agcaaccagg cgtttaaggg caccaataac tgccttaaaa aaattacgcc      480

ccgccctgcc actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag      540

ccatcacaaa cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc      600

gtataatatt tgcccatagt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt      660

aaatcaaaac tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata      720

aaccctttag ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg      780

tgtagaaact gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa cgtttcagtt      840

tgctcatgga aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct      900

ttcattgcca tacggaactc cggatgagca ttcatcaggc gggcaagaat gtgaataaag      960

gccggataaa acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc     1020

tgaacggtct ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta     1080

cgatgccatt gggatatatc aacggtggta tatccagtga tttttttctc cattttagct     1140

tccttagctc ctgaaaatct cgataactca aaaaatacgc ccggtagtga tcttatttca     1200

ttatggtgaa agttggaacc tcttacgtgc cgatcaacgt ctcattttcg ccaaaagttg     1260

gcccagggct tcccggtatc aacagggaca ccaggattta tttattctgc gaagtgatct     1320

tccgtcacag gtatttattc ggcgcaaagt gcgtcgggtg atgctgccaa cttactgatt     1380

tagtgtatga tggtgttttt gaggtgctcc agtggcttct gtttctatca gctgtccctc     1440

ctgttcagct actgacgggg tggtgcgtaa cggcaaaagc accgccggac atcagcgcta     1500

gcggagtgta tactggctta ctatgttggc actgatgagg gtgtcagtga agtgcttcat     1560

gtggcaggag aaaaaaggct gcaccggtgc gtcagcagaa tatgtgatac aggatatatt     1620

ccgcttcctc gctcactgac tcgctacgct cggtcgttcg actgcggcga gcggaaatgg     1680

cttacgaacg gggcggagat ttcctggaag atgccaggaa gatacttaac agggaagtga     1740

gagggccgcg gcaaagccgt ttttccatag gctccgcccc cctgacaagc atcacgaaat     1800

ctgacgctca aatcagtggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     1860

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg     1920

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg     1980

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg     2040

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac     2100

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa     2160

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag     2220

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga     2280

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct     2340

agatttcagt gcaatttatc tcttcaaatg tagcacctga agtcagcccc atacgatata     2400

agttgtaatt ctcatgttag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa     2460

ggctctcaag ggcatcggtc gagatcccgg tgcctaatga gtgagctaac ttacattaat     2520

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     2580

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt     2640

tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca     2700

gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg     2760

gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag atgtccgcac     2820

caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg     2880

caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac     2940

cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga     3000

gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta     3060

acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt     3120

cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg     3180

ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt     3240

taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt     3300

cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag     3360

atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc     3420

caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca     3480

gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt     3540

tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg     3600

ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac     3660

cgcgaaaggt tttgcgccat tcgatggtgt ccgggatctc gacgctctcc cttatgcgac     3720

tcctgcatta ggaaat                                                     3736


<210>  353
<211>  4118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR

<400>  353
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg gattagctga tctttaataa taaggaaatg      120

ttacattaag gttggtgggt tgtttttatg ggaaaaaatg ctttaagaac aaatgtatac      180

ttttagagag ttccccgcgc cagcggggat aaaccgcaaa cacagcatgg acgacagcca      240

ggtacctaga gttccccgcg ccagcgggga taaaccgcaa acacagcatg gacgacagcc      300

aggtacctag agttccccgc gccagcgggg ataaaccgca aacacagcat ggacgacagc      360

caggtaccta gagttccccg cgccagcggg gataaaccga aaacaaaagg ctcagtcgga      420

agactgggcc ttttgtttta accccttggg gcctctaaac gggtcttgag gggttttttg      480

ctcgagtctg gtaaagaaac cgctgctgcg aaatttgaac gccagcacat ggactcgtct      540

actagcgcag cttaattaac ctaggctgct gccaccgctg agcaataact agcataaccc      600

cttggggcct ctaaacgggt cttgaggggt tttttgctga aacctcaggc atttgagaag      660

cacacggtca cactgcttcc ggtagtcaat aaaccggtaa accagcaata gacataagcg      720

gctatttaac gaccctgccc tgaaccgacg accgggtcga atttgctttc gaatttctgc      780

cattcatccg cttattatca cttattcagg cgtagcacca ggcgtttaag ggcaccaata      840

actgccttaa aaaaattacg ccccgccctg ccactcatcg cagtactgtt gtaattcatt      900

aagcattctg ccgacatgga agccatcaca gacggcatga tgaacctgaa tcgccagcgg      960

catcagcacc ttgtcgcctt gcgtataata tttgcccata gtgaaaacgg gggcgaagaa     1020

gttgtccata ttggccacgt ttaaatcaaa actggtgaaa ctcacccagg gattggctga     1080

gacgaaaaac atattctcaa taaacccttt agggaaatag gccaggtttt caccgtaaca     1140

cgccacatct tgcgaatata tgtgtagaaa ctgccggaaa tcgtcgtggt attcactcca     1200

gagcgatgaa aacgtttcag tttgctcatg gaaaacggtg taacaagggt gaacactatc     1260

ccatatcacc agctcaccgt ctttcattgc catacggaac tccggatgag cattcatcag     1320

gcgggcaaga atgtgaataa aggccggata aaacttgtgc ttatttttct ttacggtctt     1380

taaaaaggcc gtaatatcca gctgaacggt ctggttatag gtacattgag caactgactg     1440

aaatgcctca aaatgttctt tacgatgcca ttgggatata tcaacggtgg tatatccagt     1500

gatttttttc tccattttag cttccttagc tcctgaaaat ctcgataact caaaaaatac     1560

gcccggtagt gatcttattt cattatggtg aaagttggaa cctcttacgt gccgatcaac     1620

gtctcatttt cgccaaaagt tggcccaggg cttcccggta tcaacaggga caccaggatt     1680

tatttattct gcgaagtgat cttccgtcac aggtatttat tcggcgcaaa gtgcgtcggg     1740

tgatgctgcc aacttactga tttagtgtat gatggtgttt ttgaggtgct ccagtggctt     1800

ctgtttctat cagctgtccc tcctgttcag ctactgacgg ggtggtgcgt aacggcaaaa     1860

gcaccgccgg acatcagcgc tagcggagtg tatactggct tactatgttg gcactgatga     1920

gggtgtcagt gaagtgcttc atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag     1980

aatatgtgat acaggatata ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt     2040

cgactgcggc gagcggaaat ggcttacgaa cggggcggag atttcctgga agatgccagg     2100

aagatactta acagggaagt gagagggccg cggcaaagcc gtttttccat aggctccgcc     2160

cccctgacaa gcatcacgaa atctgacgct caaatcagtg gtggcgaaac ccgacaggac     2220

tataaagata ccaggcgttt cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt     2280

tcggtttacc ggtgtcattc cgctgttatg gccgcgtttg tctcattcca cgcctgacac     2340

tcagttccgg gtaggcagtt cgctccaagc tggactgtat gcacgaaccc cccgttcagt     2400

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggaa agacatgcaa     2460

aagcaccact ggcagcagcc actggtaatt gatttagagg agttagtctt gaagtcatgc     2520

gccggttaag gctaaactga aaggacaagt tttggtgact gcgctcctcc aagccagtta     2580

cctcggttca aagagttggt agctcagaga accttcgaaa aaccgccctg caaggcggtt     2640

ttttcgtttt cagagcaaga gattacgcgc agaccaaaac gatctcaaga agatcatctt     2700

attaatcaga taaaatattt ctagatttca gtgcaattta tctcttcaaa tgtagcacct     2760

gaagtcagcc ccatacgata taagttgtaa ttctcatgtt agtcatgccc cgcgcccacc     2820

ggaaggagct gactgggttg aaggctctca agggcatcgg tcgagatccc ggtgcctaat     2880

gagtgagcta acttacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc     2940

tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     3000

ggcgccaggg tggtttttct tttcaccagt gagacgggca acagctgatt gcccttcacc     3060

gcctggccct gagagagttg cagcaagcgg tccacgctgg tttgccccag caggcgaaaa     3120

tcctgtttga tggtggttaa cggcgggata taacatgagc tgtcttcggt atcgtcgtat     3180

cccactaccg agatgtccgc accaacgcgc agcccggact cggtaatggc gcgcattgcg     3240

cccagcgcca tctgatcgtt ggcaaccagc atcgcagtgg gaacgatgcc ctcattcagc     3300

atttgcatgg tttgttgaaa accggacatg gcactccagt cgccttcccg ttccgctatc     3360

ggctgaattt gattgcgagt gagatattta tgccagccag ccagacgcag acgcgccgag     3420

acagaactta atgggcccgc taacagcgcg atttgctggt gacccaatgc gaccagatgc     3480

tccacgccca gtcgcgtacc gtcttcatgg gagaaaataa tactgttgat gggtgtctgg     3540

tcagagacat caagaaataa cgccggaaca ttagtgcagg cagcttccac agcaatggca     3600

tcctggtcat ccagcggata gttaatgatc agcccactga cgcgttgcgc gagaagattg     3660

tgcaccgccg ctttacaggc ttcgacgccg cttcgttcta ccatcgacac caccacgctg     3720

gcacccagtt gatcggcgcg agatttaatc gccgcgacaa tttgcgacgg cgcgtgcagg     3780

gccagactgg aggtggcaac gccaatcagc aacgactgtt tgcccgccag ttgttgtgcc     3840

acgcggttgg gaatgtaatt cagctccgcc atcgccgctt ccactttttc ccgcgttttc     3900

gcagaaacgt ggctggcctg gttcaccacg cgggaaacgg tctgataaga gacaccggca     3960

tactctgcga catcgtataa cgttactggt ttcacattca ccaccctgaa ttgactctct     4020

tccgggcgct atcatgccat accgcgaaag gttttgcgcc attcgatggt gtccgggatc     4080

tcgacgctct cccttatgcg actcctgcat taggaaat                             4118


<210>  354
<211>  3797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(J3/L3)

<400>  354
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccgccag tgataagtgg aatgccatgt gggctgtcga gttccccgcg ccagcgggga      180

taaaccgagt ggcagatata gcctggtggt tcaggcggcg agttccccgc gccagcgggg      240

ataaaccgga gctcgctgag caataactag cataacccct tggggcctct aaacgggtct      300

tgaggggttt tttgctgaaa cctcaggcat ttgagaagca cacggtcaca ctgcttccgg      360

tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga ccctgccctg      420

aaccgacgac cgggtcgaat ttgctttcga atttctgcca ttcatccgct tattatcact      480

tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa aaaattacgc      540

cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc cgacatggaa      600

gccatcacaa acggcatgat gaacctgaat cgccagcggc atcagcacct tgtcgccttg      660

cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat tggccacgtt      720

taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca tattctcaat      780

aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt gcgaatatat      840

gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa acgtttcagt      900

ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca gctcaccgtc      960

tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa tgtgaataaa     1020

ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg taatatccag     1080

ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa aatgttcttt     1140

acgatgccat tgggatatat caacggtggt atatccagtg atttttttct ccattttagc     1200

ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg atcttatttc     1260

attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc gccaaaagtt     1320

ggcccagggc ttcccggtat caacagggac accaggattt atttattctg cgaagtgatc     1380

ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca acttactgat     1440

ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc agctgtccct     1500

cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga catcagcgct     1560

agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg aagtgcttca     1620

tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata caggatatat     1680

tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg agcggaaatg     1740

gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa cagggaagtg     1800

agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag catcacgaaa     1860

tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac caggcgtttc     1920

ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg gtgtcattcc     1980

gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg taggcagttc     2040

gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc gccttatccg     2100

gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg gcagcagcca     2160

ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg ctaaactgaa     2220

aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa agagttggta     2280

gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc agagcaagag     2340

attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat aaaatatttc     2400

tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc catacgatat     2460

aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg actgggttga     2520

aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa cttacattaa     2580

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     2640

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt ggtttttctt     2700

ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg agagagttgc     2760

agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat ggtggttaac     2820

ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga gatgtccgca     2880

ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat ctgatcgttg     2940

gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt ttgttgaaaa     3000

ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg attgcgagtg     3060

agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa tgggcccgct     3120

aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag tcgcgtaccg     3180

tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc aagaaataac     3240

gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc cagcggatag     3300

ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc tttacaggct     3360

tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg atcggcgcga     3420

gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga ggtggcaacg     3480

ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg aatgtaattc     3540

agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg gctggcctgg     3600

ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac atcgtataac     3660

gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta tcatgccata     3720

ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc ccttatgcga     3780

ctcctgcatt aggaaat                                                    3797


<210>  355
<211>  3797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(Hsa07)

<400>  355
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccggttg atttgcctgc attggtgtta cacagtctga gttccccgcg ccagcgggga      180

taaaccgtaa gttgtgttct tctttgccta ggccttcagg agttccccgc gccagcgggg      240

ataaaccgga gctcgctgag caataactag cataacccct tggggcctct aaacgggtct      300

tgaggggttt tttgctgaaa cctcaggcat ttgagaagca cacggtcaca ctgcttccgg      360

tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga ccctgccctg      420

aaccgacgac cgggtcgaat ttgctttcga atttctgcca ttcatccgct tattatcact      480

tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa aaaattacgc      540

cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc cgacatggaa      600

gccatcacaa acggcatgat gaacctgaat cgccagcggc atcagcacct tgtcgccttg      660

cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat tggccacgtt      720

taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca tattctcaat      780

aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt gcgaatatat      840

gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa acgtttcagt      900

ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca gctcaccgtc      960

tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa tgtgaataaa     1020

ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg taatatccag     1080

ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa aatgttcttt     1140

acgatgccat tgggatatat caacggtggt atatccagtg atttttttct ccattttagc     1200

ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg atcttatttc     1260

attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc gccaaaagtt     1320

ggcccagggc ttcccggtat caacagggac accaggattt atttattctg cgaagtgatc     1380

ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca acttactgat     1440

ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc agctgtccct     1500

cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga catcagcgct     1560

agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg aagtgcttca     1620

tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata caggatatat     1680

tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg agcggaaatg     1740

gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa cagggaagtg     1800

agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag catcacgaaa     1860

tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac caggcgtttc     1920

ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg gtgtcattcc     1980

gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg taggcagttc     2040

gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc gccttatccg     2100

gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg gcagcagcca     2160

ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg ctaaactgaa     2220

aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa agagttggta     2280

gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc agagcaagag     2340

attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat aaaatatttc     2400

tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc catacgatat     2460

aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg actgggttga     2520

aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa cttacattaa     2580

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     2640

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt ggtttttctt     2700

ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg agagagttgc     2760

agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat ggtggttaac     2820

ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga gatgtccgca     2880

ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat ctgatcgttg     2940

gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt ttgttgaaaa     3000

ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg attgcgagtg     3060

agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa tgggcccgct     3120

aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag tcgcgtaccg     3180

tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc aagaaataac     3240

gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc cagcggatag     3300

ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc tttacaggct     3360

tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg atcggcgcga     3420

gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga ggtggcaacg     3480

ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg aatgtaattc     3540

agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg gctggcctgg     3600

ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac atcgtataac     3660

gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta tcatgccata     3720

ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc ccttatgcga     3780

ctcctgcatt aggaaat                                                    3797


<210>  356
<211>  7967
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas8

<400>  356
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaact agtaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatgt     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaactaa ggaggtccgc tatgcaccat caccatcacc atggaaaaat     5100

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga     5160

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa     5220

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg     5280

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga     5340

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa     5400

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct     5460

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa     5520

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc     5580

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     5640

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     5700

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     5760

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     5820

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     5880

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     5940

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     6000

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     6060

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     6120

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     6180

agacgcgcag actaatggga tcgaggaaaa cctgtacttc caatccaatg caatgaattt     6240

gcttattgat aactggatcc ctgtacgccc gcgaaacggg gggaaagtcc aaatcataaa     6300

tctgcaatcg ctatactgca gtagagatca gtggcgatta agtttgcccc gtgacgatat     6360

ggaactggcc gctttagcac tgctggtttg cattgggcaa attatcgccc cggcaaaaga     6420

tgacgttgaa tttcgacatc gcataatgaa tccgctcact gaagatgagt ttcaacaact     6480

catcgcgccg tggatagata tgttctacct taatcacgca gaacatccct ttatgcagac     6540

caaaggtgtc aaagcaaatg atgtgactcc aatggaaaaa ctgttggctg gggtaagcgg     6600

cgcgacgaat tgtgcatttg tcaatcaacc ggggcagggt gaagcattat gtggtggatg     6660

cactgcgatt gcgttattca accaggcgaa tcaggcacca ggttttggtg gtggttttaa     6720

aagcggttta cgtggaggaa cacctgtaac aacgttcgta cgtgggatcg atcttcgttc     6780

aacggtgtta ctcaatgtcc tcacattacc tcgtcttcaa aaacaatttc ctaatgaatc     6840

acatacggaa aaccaaccta cctggattaa acctatcaag tccaatgagt ctatacctgc     6900

ttcgtcaatt gggtttgtcc gtggtctatt ctggcaacca gcgcatattg aattatgcga     6960

tcccattggg attggtaaat gttcttgctg tggacaggaa agcaatttgc gttataccgg     7020

ttttcttaag gaaaaattta cctttacagt taatgggcta tggccccatc cgcattcccc     7080

ttgtctggta acagtcaaga aaggggaggt tgaggaaaaa tttcttgctt tcaccacctc     7140

cgcaccatca tggacacaaa tcagccgagt tgtggtagat aagattattc aaaatgaaaa     7200

tggaaatcgc gtggcggcgg ttgtgaatca attcagaaat attgcgccgc aaagtcctct     7260

tgaattgatt atggggggat atcgtaataa tcaagcatct attcttgaac ggcgtcatga     7320

tgtgttgatg tttaatcagg ggtggcaaca atacggcaat gtgataaacg aaatagtgac     7380

tgttggtttg ggatataaaa cagccttacg caaggcgtta tatacctttg cagaagggtt     7440

taaaaataaa gacttcaaag gggccggagt ctctgttcat gagactgcag aaaggcattt     7500

ctatcgacag agtgaattat taattcccga tgtactggcg aatgttaatt tttcccaggc     7560

tgatgaggta atagctgatt tacgagacaa acttcatcaa ttgtgtgaaa tgctatttaa     7620

tcaatctgta gctccctatg cacatcatcc taaattaata agcacattag cgcttgcccg     7680

cgccacgcta tacaaacatt tacgggagtt aaaaccgcaa ggagggccat caaatggctg     7740

ataataacat tggaagtgga taacggatcc gaattcgagc gccgtcgaca agcttgcggc     7800

cgcactcgag caccaccacc accaccactg agatccggct gctaacaaag cccgaaagga     7860

agctgagttg gctgctgcca ccgctgagca ataactagca taaccccttg gggcctctaa     7920

acgggtcttg aggggttttt tgctgaaagg aggaactata tccggat                   7967


<210>  357
<211>  6435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: StrepII-HRV3C-Cse2_Cas7_Cas5_Cas6

<400>  357
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg gcaagctgga gccacccgca gttcgaaaag      120

ggtgcacttg aagtcctctt tcagggaccc gggtaccaga tggctgatga aattgatgca      180

atggctttat atcgagcctg gcaacaactg gataatggat catgtgcgca aattagacgt      240

gtttcagaac ctgatgaatt acgcgatatc cctgcgtttt ataggctggt gcaacctttt      300

ggttgggaaa acccacgtca ccagcaggct cttttgcgca tggtgttttg cctgagcgca      360

ggaaagaatg tcatccgaca tcaggacaaa aaatcggagc aaacaacagg tatctcgttg      420

ggaagagctt tagccaatag tggaagaatt aacgagcgcc gtatctttca attaattcgg      480

gctgacagaa cagccgatat ggtccagtta cgtcgattac ttactcacgc cgaacccgta      540

cttgactggc cattaatggc caggatgttg acctggtggg gaaagcgcga acgccagcaa      600

cttctggaag attttgtatt gaccacaaac aaaaatgcgt aaggaaacct ttctatgtct      660

aactttatca atattcatgt tctgatctct cacagccctt catgtctgaa ccgcgacgat      720

atgaacatgc agaaagacgc tattttcggc ggcaaaagac gagtaagaat ttcaagtcaa      780

agccttaaac gtgcgatgcg taaaagtggt tattacgcac aaaatattgg tgaatccagt      840

ctcagaacca ttcatcttgc acaattacgt gatgttcttc ggcaaaaact tggtgaacgt      900

tttgaccaaa aaatcatcga taagacatta gcgctgctct ccggtaaatc agttgatgaa      960

gccgaaaaga tttctgccga tgcggttact ccctgggttg tgggagaaat agcctggttc     1020

tgtgagcagg ttgcaaaagc agaggctgat aatctggatg ataaaaagct gctcaaagtt     1080

cttaaggaag atattgccgc catacgtgtg aatttacagc agggtgttga tattgcgctt     1140

agtggaagaa tggcaaccag cggcatgatg actgagttgg gaaaagttga tggtgcaatg     1200

tccattgcgc atgcgatcac tactcatcag gttgattctg atattgactg gttcaccgct     1260

gtagatgatt tacaggaaca aggttctgca catctgggaa ctcaggaatt ttcatcgggt     1320

gttttttatc gttatgccaa cattaacctc gctcaacttc aggaaaattt aggtggtgcc     1380

tccagggagc aggctctgga aattgcaacc catgttgttc atatgctggc aacagaggtc     1440

cctggagcaa aacagcgtac ttatgccgct tttaaccctg cggatatggt aatggttaat     1500

ttctccgata tgccactttc tatggcaaat gcttttgaaa aagcggttaa agcgaaagat     1560

ggctttttgc aaccgtctat acaggcgttt aatcaatatt gggatcgcgt tgccaatgga     1620

tatggtctga acggagctgc tgcgcaattc agcttatctg atgtagaccc aattactgct     1680

caagttaaac aaatgcctac tttagaacag ttaaaatcct gggttcgtaa taatggcgag     1740

gcgtgaacat gagatcttat ttgatcttgc ggcttgctgg gccaatgcaa gcctgggggc     1800

agccgacctt tgaaggaacg cgacctaccg gaagatttcc gacccgaagc gggttattag     1860

ggctactcgg ggcttgtctt gggatccaac gtgatgatac ttcttcatta caggcgttat     1920

cagagagtgt gcaatttgca gtgcgctgcg atgaactcat tcttgacgat cgtcgtgtgt     1980

ctgtaacggg gttgcgtgat taccatacag tccttggagc gcgagaagat taccgtggtt     2040

tgaaaagtca tgaaacgatt caaacatggc gcgaatattt atgtgatgcc tcctttaccg     2100

tcgctctctg gttaacaccc catgcaacga tggttatctc agaacttgaa aaagcagtat     2160

taaagcctcg gtatacacct tacctggggc ggagaagttg cccactaaca cacccgcttt     2220

ttttggggac atgtcaggca tcggatcctc agaaggcgct attaaattat gagcccgttg     2280

gcggcgatat atatagtgag gaatcagtta cagggcatca tttaaaattt acggcgcgcg     2340

acgaaccgat gatcaccttg cctcgacaat ttgcttcccg agaatggtat gtgattaaag     2400

gaggtatgga tgtatctcag taaagtcatc attgccaggg cctggagcag ggatctttac     2460

caacttcacc agggattatg gcatttattt ccaaacagac cggatgctgc tcgtgatttt     2520

ctttttcatg ttgagaagcg aaacacacca gaaggctgtc atgttttatt gcagtcagcg     2580

caaatgcctg tttcaactgc cgttgcgaca gtcattaaaa ctaaacaggt tgaatttcaa     2640

cttcaggttg gtgttccact ctattttcgg cttcgggcaa atccgatcaa aactattctc     2700

gacaatcaaa agcgcctgga cagtaaaggg aatattaaac gctgtcgggt tccgttaata     2760

aaagaagcag aacaaatcgc gtggttgcaa cgtaaattgg gcaatgcggc gcgcgttgaa     2820

gatgtgcatc ccatatcgga acggccacag tatttttctg gtgatggtaa aagtggaaag     2880

atccaaacgg tttgctttga aggtgtgctc accatcaacg acgcgccagc gttaatagat     2940

cttgtacagc aaggtattgg gccagctaaa tcgatgggat gtggcttgct atctttggct     3000

ccactgtgac tgcaggcggc cgcactcgag tctggtaaag aaaccgctgc tgcgaaattt     3060

gaacgccagc acatggactc gtctactagc gcagcttaat taacctaggc tgctgccacc     3120

gctgagcaat aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg     3180

ctgaaacctc aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg     3240

gtaaaccagc aatagacata agcggctatt taacgaccct gccctgaacc gacgaccggg     3300

tcatcgtggc cggatcttgc ggcccctcgg cttgaacgaa ttgttagaca ttatttgccg     3360

actaccttgg tgatctcgcc tttcacgtag tggacaaatt cttccaactg atctgcgcgc     3420

gaggccaagc gatcttcttc ttgtccaaga taagcctgtc tagcttcaag tatgacgggc     3480

tgatactggg ccggcaggcg ctccattgcc cagtcggcag cgacatcctt cggcgcgatt     3540

ttgccggtta ctgcgctgta ccaaatgcgg gacaacgtaa gcactacatt tcgctcatcg     3600

ccagcccagt cgggcggcga gttccatagc gttaaggttt catttagcgc ctcaaataga     3660

tcctgttcag gaaccggatc aaagagttcc tccgccgctg gacctaccaa ggcaacgcta     3720

tgttctcttg cttttgtcag caagatagcc agatcaatgt cgatcgtggc tggctcgaag     3780

atacctgcaa gaatgtcatt gcgctgccat tctccaaatt gcagttcgcg cttagctgga     3840

taacgccacg gaatgatgtc gtcgtgcaca acaatggtga cttctacagc gcggagaatc     3900

tcgctctctc caggggaagc cgaagtttcc aaaaggtcgt tgatcaaagc tcgccgcgtt     3960

gtttcatcaa gccttacggt caccgtaacc agcaaatcaa tatcactgtg tggcttcagg     4020

ccgccatcca ctgcggagcc gtacaaatgt acggccagca acgtcggttc gagatggcgc     4080

tcgatgacgc caactacctc tgatagttga gtcgatactt cggcgatcac cgcttccctc     4140

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     4200

tacatatttg aatgtattta gaaaaataaa caaatagcta gctcactcgg tcgctacgct     4260

ccgggcgtga gactgcggcg ggcgctgcgg acacatacaa agttacccac agattccgtg     4320

gataagcagg ggactaacat gtgaggcaaa acagcagggc cgcgccggtg gcgtttttcc     4380

ataggctccg ccctcctgcc agagttcaca taaacagacg cttttccggt gcatctgtgg     4440

gagccgtgag gctcaaccat gaatctgaca gtacgggcga aacccgacag gacttaaaga     4500

tccccaccgt ttccggcggg tcgctccctc ttgcgctctc ctgttccgac cctgccgttt     4560

accggatacc tgttccgcct ttctccctta cgggaagtgt ggcgctttct catagctcac     4620

acactggtat ctcggctcgg tgtaggtcgt tcgctccaag ctgggctgta agcaagaact     4680

ccccgttcag cccgactgct gcgccttatc cggtaactgt tcacttgagt ccaacccgga     4740

aaagcacggt aaaacgccac tggcagcagc cattggtaac tgggagttcg cagaggattt     4800

gtttagctaa acacgcggtt gctcttgaag tgtgcgccaa agtccggcta cactggaagg     4860

acagatttgg ttgctgtgct ctgcgaaagc cagttaccac ggttaagcag ttccccaact     4920

gacttaacct tcgatcaaac cacctcccca ggtggttttt tcgtttacag ggcaaaagat     4980

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctactg aaccgctcta     5040

gatttcagtg caatttatct cttcaaatgt agcacctgaa gtcagcccca tacgatataa     5100

gttgtaattc tcatgttagt catgccccgc gcccaccgga aggagctgac tgggttgaag     5160

gctctcaagg gcatcggtcg agatcccggt gcctaatgag tgagctaact tacattaatt     5220

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     5280

atcggccaac gcgcggggag aggcggtttg cgtattgggc gccagggtgg tttttctttt     5340

caccagtgag acgggcaaca gctgattgcc cttcaccgcc tggccctgag agagttgcag     5400

caagcggtcc acgctggttt gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg     5460

cgggatataa catgagctgt cttcggtatc gtcgtatccc actaccgaga tgtccgcacc     5520

aacgcgcagc ccggactcgg taatggcgcg cattgcgccc agcgccatct gatcgttggc     5580

aaccagcatc gcagtgggaa cgatgccctc attcagcatt tgcatggttt gttgaaaacc     5640

ggacatggca ctccagtcgc cttcccgttc cgctatcggc tgaatttgat tgcgagtgag     5700

atatttatgc cagccagcca gacgcagacg cgccgagaca gaacttaatg ggcccgctaa     5760

cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc     5820

ttcatgggag aaaataatac tgttgatggg tgtctggtca gagacatcaa gaaataacgc     5880

cggaacatta gtgcaggcag cttccacagc aatggcatcc tggtcatcca gcggatagtt     5940

aatgatcagc ccactgacgc gttgcgcgag aagattgtgc accgccgctt tacaggcttc     6000

gacgccgctt cgttctacca tcgacaccac cacgctggca cccagttgat cggcgcgaga     6060

tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc agactggagg tggcaacgcc     6120

aatcagcaac gactgtttgc ccgccagttg ttgtgccacg cggttgggaa tgtaattcag     6180

ctccgccatc gccgcttcca ctttttcccg cgttttcgca gaaacgtggc tggcctggtt     6240

caccacgcgg gaaacggtct gataagagac accggcatac tctgcgacat cgtataacgt     6300

tactggtttc acattcacca ccctgaattg actctcttcc gggcgctatc atgccatacc     6360

gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg acgctctccc ttatgcgact     6420

cctgcattag gaaat                                                      6435


<210>  358
<211>  7933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_His6HRV3CCse2_Cas7_Cas5_Cas6

<400>  358
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctaa tttgcttatt gataactgga tccctgtacg cccgcgaaac ggggggaaag     1560

tccaaatcat aaatctgcaa tcgctatact gcagtagaga tcagtggcga ttaagtttgc     1620

cccgtgacga tatggaactg gccgctttag cactgctggt ttgcattggg caaattatcg     1680

ccccggcaaa agatgacgtt gaatttcgac atcgcataat gaatccgctc actgaagatg     1740

agtttcaaca actcatcgcg ccgtggatag atatgttcta ccttaatcac gcagaacatc     1800

cctttatgca gaccaaaggt gtcaaagcaa atgatgtgac tccaatggaa aaactgttgg     1860

ctggggtaag cggcgcgacg aattgtgcat ttgtcaatca accggggcag ggtgaagcat     1920

tatgtggtgg atgcactgcg attgcgttat tcaaccaggc gaatcaggca ccaggttttg     1980

gtggtggttt taaaagcggt ttacgtggag gaacacctgt aacaacgttc gtacgtggga     2040

tcgatcttcg ttcaacggtg ttactcaatg tcctcacatt acctcgtctt caaaaacaat     2100

ttcctaatga atcacatacg gaaaaccaac ctacctggat taaacctatc aagtccaatg     2160

agtctatacc tgcttcgtca attgggtttg tccgtggtct attctggcaa ccagcgcata     2220

ttgaattatg cgatcccatt gggattggta aatgttcttg ctgtggacag gaaagcaatt     2280

tgcgttatac cggttttctt aaggaaaaat ttacctttac agttaatggg ctatggcccc     2340

atccgcattc cccttgtctg gtaacagtca agaaagggga ggttgaggaa aaatttcttg     2400

ctttcaccac ctccgcacca tcatggacac aaatcagccg agttgtggta gataagatta     2460

ttcaaaatga aaatggaaat cgcgtggcgg cggttgtgaa tcaattcaga aatattgcgc     2520

cgcaaagtcc tcttgaattg attatggggg gatatcgtaa taatcaagca tctattcttg     2580

aacggcgtca tgatgtgttg atgtttaatc aggggtggca acaatacggc aatgtgataa     2640

acgaaatagt gactgttggt ttgggatata aaacagcctt acgcaaggcg ttatatacct     2700

ttgcagaagg gtttaaaaat aaagacttca aaggggccgg agtctctgtt catgagactg     2760

cagaaaggca tttctatcga cagagtgaat tattaattcc cgatgtactg gcgaatgtta     2820

atttttccca ggctgatgag gtaatagctg atttacgaga caaacttcat caattgtgtg     2880

aaatgctatt taatcaatct gtagctccct atgcacatca tcctaaatta ataagcacat     2940

tagcgcttgc ccgcgccacg ctatacaaac atttacggga gttaaaaccg caaggagggc     3000

catcaaatgg ctgagcatca ccaccatcat cacggtgcac ttgaagtcct ctttcaggga     3060

cccgggtacc agatggctga tgaaattgat gcaatggctt tatatcgagc ctggcaacaa     3120

ctggataatg gatcatgtgc gcaaattaga cgtgtttcag aacctgatga attacgcgat     3180

atccctgcgt tttataggct ggtgcaacct tttggttggg aaaacccacg tcaccagcag     3240

gctcttttgc gcatggtgtt ttgcctgagc gcaggaaaga atgtcatccg acatcaggac     3300

aaaaaatcgg agcaaacaac aggtatctcg ttgggaagag ctttagccaa tagtggaaga     3360

attaacgagc gccgtatctt tcaattaatt cgggctgaca gaacagccga tatggtccag     3420

ttacgtcgat tacttactca cgccgaaccc gtacttgact ggccattaat ggccaggatg     3480

ttgacctggt ggggaaagcg cgaacgccag caacttctgg aagattttgt attgaccaca     3540

aacaaaaatg cgtaaggaaa cctttctatg tctaacttta tcaatattca tgttctgatc     3600

tctcacagcc cttcatgtct gaaccgcgac gatatgaaca tgcagaaaga cgctattttc     3660

ggcggcaaaa gacgagtaag aatttcaagt caaagcctta aacgtgcgat gcgtaaaagt     3720

ggttattacg cacaaaatat tggtgaatcc agtctcagaa ccattcatct tgcacaatta     3780

cgtgatgttc ttcggcaaaa acttggtgaa cgttttgacc aaaaaatcat cgataagaca     3840

ttagcgctgc tctccggtaa atcagttgat gaagccgaaa agatttctgc cgatgcggtt     3900

actccctggg ttgtgggaga aatagcctgg ttctgtgagc aggttgcaaa agcagaggct     3960

gataatctgg atgataaaaa gctgctcaaa gttcttaagg aagatattgc cgccatacgt     4020

gtgaatttac agcagggtgt tgatattgcg cttagtggaa gaatggcaac cagcggcatg     4080

atgactgagt tgggaaaagt tgatggtgca atgtccattg cgcatgcgat cactactcat     4140

caggttgatt ctgatattga ctggttcacc gctgtagatg atttacagga acaaggttct     4200

gcacatctgg gaactcagga attttcatcg ggtgtttttt atcgttatgc caacattaac     4260

ctcgctcaac ttcaggaaaa tttaggtggt gcctccaggg agcaggctct ggaaattgca     4320

acccatgttg ttcatatgct ggcaacagag gtccctggag caaaacagcg tacttatgcc     4380

gcttttaacc ctgcggatat ggtaatggtt aatttctccg atatgccact ttctatggca     4440

aatgcttttg aaaaagcggt taaagcgaaa gatggctttt tgcaaccgtc tatacaggcg     4500

tttaatcaat attgggatcg cgttgccaat ggatatggtc tgaacggagc tgctgcgcaa     4560

ttcagcttat ctgatgtaga cccaattact gctcaagtta aacaaatgcc tactttagaa     4620

cagttaaaat cctgggttcg taataatggc gaggcgtgaa catgagatct tatttgatct     4680

tgcggcttgc tgggccaatg caagcctggg ggcagccgac ctttgaagga acgcgaccta     4740

ccggaagatt tccgacccga agcgggttat tagggctact cggggcttgt cttgggatcc     4800

aacgtgatga tacttcttca ttacaggcgt tatcagagag tgtgcaattt gcagtgcgct     4860

gcgatgaact cattcttgac gatcgtcgtg tgtctgtaac ggggttgcgt gattaccata     4920

cagtccttgg agcgcgagaa gattaccgtg gtttgaaaag tcatgaaacg attcaaacat     4980

ggcgcgaata tttatgtgat gcctccttta ccgtcgctct ctggttaaca ccccatgcaa     5040

cgatggttat ctcagaactt gaaaaagcag tattaaagcc tcggtataca ccttacctgg     5100

ggcggagaag ttgcccacta acacacccgc tttttttggg gacatgtcag gcatcggatc     5160

ctcagaaggc gctattaaat tatgagcccg ttggcggcga tatatatagt gaggaatcag     5220

ttacagggca tcatttaaaa tttacggcgc gcgacgaacc gatgatcacc ttgcctcgac     5280

aatttgcttc ccgagaatgg tatgtgatta aaggaggtat ggatgtatct cagtaaagtc     5340

atcattgcca gggcctggag cagggatctt taccaacttc accagggatt atggcattta     5400

tttccaaaca gaccggatgc tgctcgtgat tttctttttc atgttgagaa gcgaaacaca     5460

ccagaaggct gtcatgtttt attgcagtca gcgcaaatgc ctgtttcaac tgccgttgcg     5520

acagtcatta aaactaaaca ggttgaattt caacttcagg ttggtgttcc actctatttt     5580

cggcttcggg caaatccgat caaaactatt ctcgacaatc aaaagcgcct ggacagtaaa     5640

gggaatatta aacgctgtcg ggttccgtta ataaaagaag cagaacaaat cgcgtggttg     5700

caacgtaaat tgggcaatgc ggcgcgcgtt gaagatgtgc atcccatatc ggaacggcca     5760

cagtattttt ctggtgatgg taaaagtgga aagatccaaa cggtttgctt tgaaggtgtg     5820

ctcaccatca acgacgcgcc agcgttaata gatcttgtac agcaaggtat tgggccagct     5880

aaatcgatgg gatgtggctt gctatctttg gctccactgt gactgcaggc ggccgcactc     5940

gagtctggta aagaaaccgc tgctgcgaaa tttgaacgcc agcacatgga ctcgtctact     6000

agcgcagctt aattaaccta ggctgctgcc accgctgagc aataactagc ataacccctt     6060

ggggcctcta aacgggtctt gaggggtttt ttgctgaaac ctcaggcatt tgagaagcac     6120

acggtcacac tgcttccggt agtcaataaa ccggtaaacc agcaatagac ataagcggct     6180

atttaacgac cctgccctga accgacgacc gggtcatcgt ggccggatct tgcggcccct     6240

cggcttgaac gaattgttag acattatttg ccgactacct tggtgatctc gcctttcacg     6300

tagtggacaa attcttccaa ctgatctgcg cgcgaggcca agcgatcttc ttcttgtcca     6360

agataagcct gtctagcttc aagtatgacg ggctgatact gggccggcag gcgctccatt     6420

gcccagtcgg cagcgacatc cttcggcgcg attttgccgg ttactgcgct gtaccaaatg     6480

cgggacaacg taagcactac atttcgctca tcgccagccc agtcgggcgg cgagttccat     6540

agcgttaagg tttcatttag cgcctcaaat agatcctgtt caggaaccgg atcaaagagt     6600

tcctccgccg ctggacctac caaggcaacg ctatgttctc ttgcttttgt cagcaagata     6660

gccagatcaa tgtcgatcgt ggctggctcg aagatacctg caagaatgtc attgcgctgc     6720

cattctccaa attgcagttc gcgcttagct ggataacgcc acggaatgat gtcgtcgtgc     6780

acaacaatgg tgacttctac agcgcggaga atctcgctct ctccagggga agccgaagtt     6840

tccaaaaggt cgttgatcaa agctcgccgc gttgtttcat caagccttac ggtcaccgta     6900

accagcaaat caatatcact gtgtggcttc aggccgccat ccactgcgga gccgtacaaa     6960

tgtacggcca gcaacgtcgg ttcgagatgg cgctcgatga cgccaactac ctctgatagt     7020

tgagtcgata cttcggcgat caccgcttcc ctcatactct tcctttttca atattattga     7080

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     7140

aaacaaatag ctagctcact cggtcgctac gctccgggcg tgagactgcg gcgggcgctg     7200

cggacacata caaagttacc cacagattcc gtggataagc aggggactaa catgtgaggc     7260

aaaacagcag ggccgcgccg gtggcgtttt tccataggct ccgccctcct gccagagttc     7320

acataaacag acgcttttcc ggtgcatctg tgggagccgt gaggctcaac catgaatctg     7380

acagtacggg cgaaacccga caggacttaa agatccccac cgtttccggc gggtcgctcc     7440

ctcttgcgct ctcctgttcc gaccctgccg tttaccggat acctgttccg cctttctccc     7500

ttacgggaag tgtggcgctt tctcatagct cacacactgg tatctcggct cggtgtaggt     7560

cgttcgctcc aagctgggct gtaagcaaga actccccgtt cagcccgact gctgcgcctt     7620

atccggtaac tgttcacttg agtccaaccc ggaaaagcac ggtaaaacgc cactggcagc     7680

agccattggt aactgggagt tcgcagagga tttgtttagc taaacacgcg gttgctcttg     7740

aagtgtgcgc caaagtccgg ctacactgga aggacagatt tggttgctgt gctctgcgaa     7800

agccagttac cacggttaag cagttcccca actgacttaa ccttcgatca aaccacctcc     7860

ccaggtggtt ttttcgttta cagggcaaaa gattacgcgc agaaaaaaag gatctcaaga     7920

agatcctttg atc                                                        7933


<210>  359
<211>  8644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FokI30aaCas8_His6HRV3CCse2_Cas7_Cas5_Cas6

<400>  359
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctcc gaaaaaaaag cgcaaagtgg gtggctctca actggttaaa agcgaactgg     1560

aagagaaaaa aagtgaactg cgccacaaac tgaaatatgt gccgcatgaa tatatcgagc     1620

tgattgaaat tgcacgtaat ccgacccagg atcgtattct ggaaatgaaa gtgatggaat     1680

tttttatgaa agtgtacggc tatcgcggtg aacatctggg tggtagccgt aaaccggatg     1740

gtgcaattta taccgttggt agcccgattg attatggtgt tattgttgat accaaagcct     1800

atagcggtgg ttataatctg ccgattggtc aggcagatga aatgcagcgt tatgtggaag     1860

aaaatcagac ccgtaacaaa catattaatc cgaatgaatg gtggaaagtt tatccgagca     1920

gcgttaccga gtttaaattc ctgtttgtta gcggtcactt caaaggcaac tataaagcac     1980

agctgacccg tctgaatcat attaccaatt gtaatggtgc agttctgagc gttgaagaac     2040

tgctgattgg tggtgaaatg attaaagcag gcaccctgac cctggaagaa gttcgtcgca     2100

aatttaacaa tggcgaaatc aacttttcag gcagcgaaac gccgggtaca agtgagtcag     2160

caactccaga gagcggcggc agtggtagta gtgggggatc tgggtcatct ggtgggatga     2220

atttgcttat tgataactgg attcctgtac gcccgcgaaa cggggggaaa gtccaaatca     2280

taaatctgca atcgctatac tgcagtagag atcagtggcg attaagtttg ccccgtgacg     2340

atatggaact ggccgcttta gcactgctgg tttgcattgg gcaaattatc gccccggcaa     2400

aagatgacgt tgaatttcga catcgcataa tgaatccgct cactgaagat gagtttcaac     2460

aactcatcgc gccgtggata gatatgttct accttaatca cgcagaacat ccctttatgc     2520

agaccaaagg tgtcaaagca aatgatgtga ctccaatgga aaaactgttg gctggggtaa     2580

gcggcgcgac gaattgtgca tttgtcaatc aaccggggca gggtgaagca ttatgtggtg     2640

gatgcactgc gattgcgtta ttcaaccagg cgaatcaggc accaggtttt ggtggtggtt     2700

ttaaaagcgg tttacgtgga ggaacacctg taacaacgtt cgtacgtggg atcgatcttc     2760

gttcaacggt gttactcaat gtcctcacat tacctcgtct tcaaaaacaa tttcctaatg     2820

aatcacatac ggaaaaccaa cctacctgga ttaaacctat caagtccaat gagtctatac     2880

ctgcttcgtc aattgggttt gtccgtggtc tattctggca accagcgcat attgaattat     2940

gcgatcccat tgggattggt aaatgttctt gctgtggaca ggaaagcaat ttgcgttata     3000

ccggttttct taaggaaaaa tttaccttta cagttaatgg gctatggccc catccgcatt     3060

ccccttgtct ggtaacagtc aagaaagggg aggttgagga aaaatttctt gctttcacca     3120

cctccgcacc atcatggaca caaatcagcc gagttgtggt agataagatt attcaaaatg     3180

aaaatggaaa tcgcgtggcg gcggttgtga atcaattcag aaatattgcg ccgcaaagtc     3240

ctcttgaatt gattatgggg ggatatcgta ataatcaagc atctattctt gaacggcgtc     3300

atgatgtgtt gatgtttaat caggggtggc aacaatacgg caatgtgata aacgaaatag     3360

tgactgttgg tttgggatat aaaacagcct tacgcaaggc gttatatacc tttgcagaag     3420

ggtttaaaaa taaagacttc aaaggggccg gagtctctgt tcatgagact gcagaaaggc     3480

atttctatcg acagagtgaa ttattaattc ccgatgtact ggcgaatgtt aatttttccc     3540

aggctgatga ggtaatagct gatttacgag acaaacttca tcaattgtgt gaaatgctat     3600

ttaatcaatc tgtagctccc tatgcacatc atcctaaatt aataagcaca ttagcgcttg     3660

cccgcgccac gctatacaaa catttacggg agttaaaacc gcaaggaggg ccatcaaatg     3720

gctgagcatc accaccatca tcacggtgca cttgaagtcc tctttcaggg acccgggtac     3780

cagatggctg atgaaattga tgcaatggct ttatatcgag cctggcaaca actggataat     3840

ggatcatgtg cgcaaattag acgtgtttca gaacctgatg aattacgcga tatccctgcg     3900

ttttataggc tggtgcaacc ttttggttgg gaaaacccac gtcaccagca ggctcttttg     3960

cgcatggtgt tttgcctgag cgcaggaaag aatgtcatcc gacatcagga caaaaaatcg     4020

gagcaaacaa caggtatctc gttgggaaga gctttagcca atagtggaag aattaacgag     4080

cgccgtatct ttcaattaat tcgggctgac agaacagccg atatggtcca gttacgtcga     4140

ttacttactc acgccgaacc cgtacttgac tggccattaa tggccaggat gttgacctgg     4200

tggggaaagc gcgaacgcca gcaacttctg gaagattttg tattgaccac aaacaaaaat     4260

gcgtaaggaa acctttctat gtctaacttt atcaatattc atgttctgat ctctcacagc     4320

ccttcatgtc tgaaccgcga cgatatgaac atgcagaaag acgctatttt cggcggcaaa     4380

agacgagtaa gaatttcaag tcaaagcctt aaacgtgcga tgcgtaaaag tggttattac     4440

gcacaaaata ttggtgaatc cagtctcaga accattcatc ttgcacaatt acgtgatgtt     4500

cttcggcaaa aacttggtga acgttttgac caaaaaatca tcgataagac attagcgctg     4560

ctctccggta aatcagttga tgaagccgaa aagatttctg ccgatgcggt tactccctgg     4620

gttgtgggag aaatagcctg gttctgtgag caggttgcaa aagcagaggc tgataatctg     4680

gatgataaaa agctgctcaa agttcttaag gaagatattg ccgccatacg tgtgaattta     4740

cagcagggtg ttgatattgc gcttagtgga agaatggcaa ccagcggcat gatgactgag     4800

ttgggaaaag ttgatggtgc aatgtccatt gcgcatgcga tcactactca tcaggttgat     4860

tctgatattg actggttcac cgctgtagat gatttacagg aacaaggttc tgcacatctg     4920

ggaactcagg aattttcatc gggtgttttt tatcgttatg ccaacattaa cctcgctcaa     4980

cttcaggaaa atttaggtgg tgcctccagg gagcaggctc tggaaattgc aacccatgtt     5040

gttcatatgc tggcaacaga ggtccctgga gcaaaacagc gtacttatgc cgcttttaac     5100

cctgcggata tggtaatggt taatttctcc gatatgccac tttctatggc aaatgctttt     5160

gaaaaagcgg ttaaagcgaa agatggcttt ttgcaaccgt ctatacaggc gtttaatcaa     5220

tattgggatc gcgttgccaa tggatatggt ctgaacggag ctgctgcgca attcagctta     5280

tctgatgtag acccaattac tgctcaagtt aaacaaatgc ctactttaga acagttaaaa     5340

tcctgggttc gtaataatgg cgaggcgtga acatgagatc ttatttgatc ttgcggcttg     5400

ctgggccaat gcaagcctgg gggcagccga cctttgaagg aacgcgacct accggaagat     5460

ttccgacccg aagcgggtta ttagggctac tcggggcttg tcttgggatc caacgtgatg     5520

atacttcttc attacaggcg ttatcagaga gtgtgcaatt tgcagtgcgc tgcgatgaac     5580

tcattcttga cgatcgtcgt gtgtctgtaa cggggttgcg tgattaccat acagtccttg     5640

gagcgcgaga agattaccgt ggtttgaaaa gtcatgaaac gattcaaaca tggcgcgaat     5700

atttatgtga tgcctccttt accgtcgctc tctggttaac accccatgca acgatggtta     5760

tctcagaact tgaaaaagca gtattaaagc ctcggtatac accttacctg gggcggagaa     5820

gttgcccact aacacacccg ctttttttgg ggacatgtca ggcatcggat cctcagaagg     5880

cgctattaaa ttatgagccc gttggcggcg atatatatag tgaggaatca gttacagggc     5940

atcatttaaa atttacggcg cgcgacgaac cgatgatcac cttgcctcga caatttgctt     6000

cccgagaatg gtatgtgatt aaaggaggta tggatgtatc tcagtaaagt catcattgcc     6060

agggcctgga gcagggatct ttaccaactt caccagggat tatggcattt atttccaaac     6120

agaccggatg ctgctcgtga ttttcttttt catgttgaga agcgaaacac accagaaggc     6180

tgtcatgttt tattgcagtc agcgcaaatg cctgtttcaa ctgccgttgc gacagtcatt     6240

aaaactaaac aggttgaatt tcaacttcag gttggtgttc cactctattt tcggcttcgg     6300

gcaaatccga tcaaaactat tctcgacaat caaaagcgcc tggacagtaa agggaatatt     6360

aaacgctgtc gggttccgtt aataaaagaa gcagaacaaa tcgcgtggtt gcaacgtaaa     6420

ttgggcaatg cggcgcgcgt tgaagatgtg catcccatat cggaacggcc acagtatttt     6480

tctggtgatg gtaaaagtgg aaagatccaa acggtttgct ttgaaggtgt gctcaccatc     6540

aacgacgcgc cagcgttaat agatcttgta cagcaaggta ttgggccagc taaatcgatg     6600

ggatgtggct tgctatcttt ggctccactg tgactgcagg cggccgcact cgagtctggt     6660

aaagaaaccg ctgctgcgaa atttgaacgc cagcacatgg actcgtctac tagcgcagct     6720

taattaacct aggctgctgc caccgctgag caataactag cataacccct tggggcctct     6780

aaacgggtct tgaggggttt tttgctgaaa cctcaggcat ttgagaagca cacggtcaca     6840

ctgcttccgg tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga     6900

ccctgccctg aaccgacgac cgggtcatcg tggccggatc ttgcggcccc tcggcttgaa     6960

cgaattgtta gacattattt gccgactacc ttggtgatct cgcctttcac gtagtggaca     7020

aattcttcca actgatctgc gcgcgaggcc aagcgatctt cttcttgtcc aagataagcc     7080

tgtctagctt caagtatgac gggctgatac tgggccggca ggcgctccat tgcccagtcg     7140

gcagcgacat ccttcggcgc gattttgccg gttactgcgc tgtaccaaat gcgggacaac     7200

gtaagcacta catttcgctc atcgccagcc cagtcgggcg gcgagttcca tagcgttaag     7260

gtttcattta gcgcctcaaa tagatcctgt tcaggaaccg gatcaaagag ttcctccgcc     7320

gctggaccta ccaaggcaac gctatgttct cttgcttttg tcagcaagat agccagatca     7380

atgtcgatcg tggctggctc gaagatacct gcaagaatgt cattgcgctg ccattctcca     7440

aattgcagtt cgcgcttagc tggataacgc cacggaatga tgtcgtcgtg cacaacaatg     7500

gtgacttcta cagcgcggag aatctcgctc tctccagggg aagccgaagt ttccaaaagg     7560

tcgttgatca aagctcgccg cgttgtttca tcaagcctta cggtcaccgt aaccagcaaa     7620

tcaatatcac tgtgtggctt caggccgcca tccactgcgg agccgtacaa atgtacggcc     7680

agcaacgtcg gttcgagatg gcgctcgatg acgccaacta cctctgatag ttgagtcgat     7740

acttcggcga tcaccgcttc cctcatactc ttcctttttc aatattattg aagcatttat     7800

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     7860

gctagctcac tcggtcgcta cgctccgggc gtgagactgc ggcgggcgct gcggacacat     7920

acaaagttac ccacagattc cgtggataag caggggacta acatgtgagg caaaacagca     7980

gggccgcgcc ggtggcgttt ttccataggc tccgccctcc tgccagagtt cacataaaca     8040

gacgcttttc cggtgcatct gtgggagccg tgaggctcaa ccatgaatct gacagtacgg     8100

gcgaaacccg acaggactta aagatcccca ccgtttccgg cgggtcgctc cctcttgcgc     8160

tctcctgttc cgaccctgcc gtttaccgga tacctgttcc gcctttctcc cttacgggaa     8220

gtgtggcgct ttctcatagc tcacacactg gtatctcggc tcggtgtagg tcgttcgctc     8280

caagctgggc tgtaagcaag aactccccgt tcagcccgac tgctgcgcct tatccggtaa     8340

ctgttcactt gagtccaacc cggaaaagca cggtaaaacg ccactggcag cagccattgg     8400

taactgggag ttcgcagagg atttgtttag ctaaacacgc ggttgctctt gaagtgtgcg     8460

ccaaagtccg gctacactgg aaggacagat ttggttgctg tgctctgcga aagccagtta     8520

ccacggttaa gcagttcccc aactgactta accttcgatc aaaccacctc cccaggtggt     8580

tttttcgttt acagggcaaa agattacgcg cagaaaaaaa ggatctcaag aagatccttt     8640

gatc                                                                  8644


<210>  360
<211>  8710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FokI30aaCas8_His6HRV3CCse2_Cas7_Cas5_NLSCas6

<400>  360
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctcc gaaaaaaaag cgcaaagtgg gtggctctca actggttaaa agcgaactgg     1560

aagagaaaaa aagtgaactg cgccacaaac tgaaatatgt gccgcatgaa tatatcgagc     1620

tgattgaaat tgcacgtaat ccgacccagg atcgtattct ggaaatgaaa gtgatggaat     1680

tttttatgaa agtgtacggc tatcgcggtg aacatctggg tggtagccgt aaaccggatg     1740

gtgcaattta taccgttggt agcccgattg attatggtgt tattgttgat accaaagcct     1800

atagcggtgg ttataatctg ccgattggtc aggcagatga aatgcagcgt tatgtggaag     1860

aaaatcagac ccgtaacaaa catattaatc cgaatgaatg gtggaaagtt tatccgagca     1920

gcgttaccga gtttaaattc ctgtttgtta gcggtcactt caaaggcaac tataaagcac     1980

agctgacccg tctgaatcat attaccaatt gtaatggtgc agttctgagc gttgaagaac     2040

tgctgattgg tggtgaaatg attaaagcag gcaccctgac cctggaagaa gttcgtcgca     2100

aatttaacaa tggcgaaatc aacttttcag gcagcgaaac gccgggtaca agtgagtcag     2160

caactccaga gagcggcggc agtggtagta gtgggggatc tgggtcatct ggtgggatga     2220

atttgcttat tgataactgg attcctgtac gcccgcgaaa cggggggaaa gtccaaatca     2280

taaatctgca atcgctatac tgcagtagag atcagtggcg attaagtttg ccccgtgacg     2340

atatggaact ggccgcttta gcactgctgg tttgcattgg gcaaattatc gccccggcaa     2400

aagatgacgt tgaatttcga catcgcataa tgaatccgct cactgaagat gagtttcaac     2460

aactcatcgc gccgtggata gatatgttct accttaatca cgcagaacat ccctttatgc     2520

agaccaaagg tgtcaaagca aatgatgtga ctccaatgga aaaactgttg gctggggtaa     2580

gcggcgcgac gaattgtgca tttgtcaatc aaccggggca gggtgaagca ttatgtggtg     2640

gatgcactgc gattgcgtta ttcaaccagg cgaatcaggc accaggtttt ggtggtggtt     2700

ttaaaagcgg tttacgtgga ggaacacctg taacaacgtt cgtacgtggg atcgatcttc     2760

gttcaacggt gttactcaat gtcctcacat tacctcgtct tcaaaaacaa tttcctaatg     2820

aatcacatac ggaaaaccaa cctacctgga ttaaacctat caagtccaat gagtctatac     2880

ctgcttcgtc aattgggttt gtccgtggtc tattctggca accagcgcat attgaattat     2940

gcgatcccat tgggattggt aaatgttctt gctgtggaca ggaaagcaat ttgcgttata     3000

ccggttttct taaggaaaaa tttaccttta cagttaatgg gctatggccc catccgcatt     3060

ccccttgtct ggtaacagtc aagaaagggg aggttgagga aaaatttctt gctttcacca     3120

cctccgcacc atcatggaca caaatcagcc gagttgtggt agataagatt attcaaaatg     3180

aaaatggaaa tcgcgtggcg gcggttgtga atcaattcag aaatattgcg ccgcaaagtc     3240

ctcttgaatt gattatgggg ggatatcgta ataatcaagc atctattctt gaacggcgtc     3300

atgatgtgtt gatgtttaat caggggtggc aacaatacgg caatgtgata aacgaaatag     3360

tgactgttgg tttgggatat aaaacagcct tacgcaaggc gttatatacc tttgcagaag     3420

ggtttaaaaa taaagacttc aaaggggccg gagtctctgt tcatgagact gcagaaaggc     3480

atttctatcg acagagtgaa ttattaattc ccgatgtact ggcgaatgtt aatttttccc     3540

aggctgatga ggtaatagct gatttacgag acaaacttca tcaattgtgt gaaatgctat     3600

ttaatcaatc tgtagctccc tatgcacatc atcctaaatt aataagcaca ttagcgcttg     3660

cccgcgccac gctatacaaa catttacggg agttaaaacc gcaaggaggg ccatcaaatg     3720

gctgagcatc accaccatca tcacggtgca cttgaagtcc tctttcaggg acccgggtac     3780

cagatggctg atgaaattga tgcaatggct ttatatcgag cctggcaaca actggataat     3840

ggatcatgtg cgcaaattag acgtgtttca gaacctgatg aattacgcga tatccctgcg     3900

ttttataggc tggtgcaacc ttttggttgg gaaaacccac gtcaccagca ggctcttttg     3960

cgcatggtgt tttgcctgag cgcaggaaag aatgtcatcc gacatcagga caaaaaatcg     4020

gagcaaacaa caggtatctc gttgggaaga gctttagcca atagtggaag aattaacgag     4080

cgccgtatct ttcaattaat tcgggctgac agaacagccg atatggtcca gttacgtcga     4140

ttacttactc acgccgaacc cgtacttgac tggccattaa tggccaggat gttgacctgg     4200

tggggaaagc gcgaacgcca gcaacttctg gaagattttg tattgaccac aaacaaaaat     4260

gcgtaaggaa acctttctat gtctaacttt atcaatattc atgttctgat ctctcacagc     4320

ccttcatgtc tgaaccgcga cgatatgaac atgcagaaag acgctatttt cggcggcaaa     4380

agacgagtaa gaatttcaag tcaaagcctt aaacgtgcga tgcgtaaaag tggttattac     4440

gcacaaaata ttggtgaatc cagtctcaga accattcatc ttgcacaatt acgtgatgtt     4500

cttcggcaaa aacttggtga acgttttgac caaaaaatca tcgataagac attagcgctg     4560

ctctccggta aatcagttga tgaagccgaa aagatttctg ccgatgcggt tactccctgg     4620

gttgtgggag aaatagcctg gttctgtgag caggttgcaa aagcagaggc tgataatctg     4680

gatgataaaa agctgctcaa agttcttaag gaagatattg ccgccatacg tgtgaattta     4740

cagcagggtg ttgatattgc gcttagtgga agaatggcaa ccagcggcat gatgactgag     4800

ttgggaaaag ttgatggtgc aatgtccatt gcgcatgcga tcactactca tcaggttgat     4860

tctgatattg actggttcac cgctgtagat gatttacagg aacaaggttc tgcacatctg     4920

ggaactcagg aattttcatc gggtgttttt tatcgttatg ccaacattaa cctcgctcaa     4980

cttcaggaaa atttaggtgg tgcctccagg gagcaggctc tggaaattgc aacccatgtt     5040

gttcatatgc tggcaacaga ggtccctgga gcaaaacagc gtacttatgc cgcttttaac     5100

cctgcggata tggtaatggt taatttctcc gatatgccac tttctatggc aaatgctttt     5160

gaaaaagcgg ttaaagcgaa agatggcttt ttgcaaccgt ctatacaggc gtttaatcaa     5220

tattgggatc gcgttgccaa tggatatggt ctgaacggag ctgctgcgca attcagctta     5280

tctgatgtag acccaattac tgctcaagtt aaacaaatgc ctactttaga acagttaaaa     5340

tcctgggttc gtaataatgg cgaggcgtga acatgagatc ttatttgatc ttgcggcttg     5400

ctgggccaat gcaagcctgg gggcagccga cctttgaagg aacgcgacct accggaagat     5460

ttccgacccg aagcgggtta ttagggctac tcggggcttg tcttgggatc caacgtgatg     5520

atacttcttc attacaggcg ttatcagaga gtgtgcaatt tgcagtgcgc tgcgatgaac     5580

tcattcttga cgatcgtcgt gtgtctgtaa cggggttgcg tgattaccat acagtccttg     5640

gagcgcgaga agattaccgt ggtttgaaaa gtcatgaaac gattcaaaca tggcgcgaat     5700

atttatgtga tgcctccttt accgtcgctc tctggttaac accccatgca acgatggtta     5760

tctcagaact tgaaaaagca gtattaaagc ctcggtatac accttacctg gggcggagaa     5820

gttgcccact aacacacccg ctttttttgg ggacatgtca ggcatcggat cctcagaagg     5880

cgctattaaa ttatgagccc gttggcggcg atatatatag tgaggaatca gttacagggc     5940

atcatttaaa atttacggcg cgcgacgaac cgatgatcac cttgcctcga caatttgctt     6000

cccgagaatg gtatgtgatt aaaggaggta tggatgtatc tcagtaatta ataaaggagg     6060

tatataatgc caaagaaaaa acgtaaggtt ggcggtagca tgtacctcag caaagtcatc     6120

attgccaggg cctggagcag ggatctttac caacttcacc agggattatg gcatttattt     6180

ccaaacagac cggatgctgc tcgtgatttt ctttttcatg ttgagaagcg aaacacacca     6240

gaaggctgtc atgttttatt gcagtcagcg caaatgcctg tttcaactgc cgttgcgaca     6300

gtcattaaaa ctaaacaggt tgaatttcaa cttcaggttg gtgttccact ctattttcgg     6360

cttcgggcaa atccgatcaa aactattctc gacaatcaaa agcgcctgga cagtaaaggg     6420

aatattaaac gctgtcgggt tccgttaata aaagaagcag aacaaatcgc gtggttgcaa     6480

cgtaaattgg gcaatgcggc gcgcgttgaa gatgtgcatc ccatatcgga acggccacag     6540

tatttttctg gtgatggtaa aagtggaaag atccaaacgg tttgctttga aggtgtgctc     6600

accatcaacg acgcgccagc gttaatagat cttgtacagc aaggtattgg gccagctaaa     6660

tcgatgggat gtggcttgct atctttggct ccactgtgac tgcaggcggc cgcactcgag     6720

tctggtaaag aaaccgctgc tgcgaaattt gaacgccagc acatggactc gtctactagc     6780

gcagcttaat taacctaggc tgctgccacc gctgagcaat aactagcata accccttggg     6840

gcctctaaac gggtcttgag gggttttttg ctgaaacctc aggcatttga gaagcacacg     6900

gtcacactgc ttccggtagt caataaaccg gtaaaccagc aatagacata agcggctatt     6960

taacgaccct gccctgaacc gacgaccggg tcatcgtggc cggatcttgc ggcccctcgg     7020

cttgaacgaa ttgttagaca ttatttgccg actaccttgg tgatctcgcc tttcacgtag     7080

tggacaaatt cttccaactg atctgcgcgc gaggccaagc gatcttcttc ttgtccaaga     7140

taagcctgtc tagcttcaag tatgacgggc tgatactggg ccggcaggcg ctccattgcc     7200

cagtcggcag cgacatcctt cggcgcgatt ttgccggtta ctgcgctgta ccaaatgcgg     7260

gacaacgtaa gcactacatt tcgctcatcg ccagcccagt cgggcggcga gttccatagc     7320

gttaaggttt catttagcgc ctcaaataga tcctgttcag gaaccggatc aaagagttcc     7380

tccgccgctg gacctaccaa ggcaacgcta tgttctcttg cttttgtcag caagatagcc     7440

agatcaatgt cgatcgtggc tggctcgaag atacctgcaa gaatgtcatt gcgctgccat     7500

tctccaaatt gcagttcgcg cttagctgga taacgccacg gaatgatgtc gtcgtgcaca     7560

acaatggtga cttctacagc gcggagaatc tcgctctctc caggggaagc cgaagtttcc     7620

aaaaggtcgt tgatcaaagc tcgccgcgtt gtttcatcaa gccttacggt caccgtaacc     7680

agcaaatcaa tatcactgtg tggcttcagg ccgccatcca ctgcggagcc gtacaaatgt     7740

acggccagca acgtcggttc gagatggcgc tcgatgacgc caactacctc tgatagttga     7800

gtcgatactt cggcgatcac cgcttccctc atactcttcc tttttcaata ttattgaagc     7860

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     7920

caaatagcta gctcactcgg tcgctacgct ccgggcgtga gactgcggcg ggcgctgcgg     7980

acacatacaa agttacccac agattccgtg gataagcagg ggactaacat gtgaggcaaa     8040

acagcagggc cgcgccggtg gcgtttttcc ataggctccg ccctcctgcc agagttcaca     8100

taaacagacg cttttccggt gcatctgtgg gagccgtgag gctcaaccat gaatctgaca     8160

gtacgggcga aacccgacag gacttaaaga tccccaccgt ttccggcggg tcgctccctc     8220

ttgcgctctc ctgttccgac cctgccgttt accggatacc tgttccgcct ttctccctta     8280

cgggaagtgt ggcgctttct catagctcac acactggtat ctcggctcgg tgtaggtcgt     8340

tcgctccaag ctgggctgta agcaagaact ccccgttcag cccgactgct gcgccttatc     8400

cggtaactgt tcacttgagt ccaacccgga aaagcacggt aaaacgccac tggcagcagc     8460

cattggtaac tgggagttcg cagaggattt gtttagctaa acacgcggtt gctcttgaag     8520

tgtgcgccaa agtccggcta cactggaagg acagatttgg ttgctgtgct ctgcgaaagc     8580

cagttaccac ggttaagcag ttccccaact gacttaacct tcgatcaaac cacctcccca     8640

ggtggttttt tcgtttacag ggcaaaagat tacgcgcaga aaaaaaggat ctcaagaaga     8700

tcctttgatc                                                            8710


<210>  361
<211>  8687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FokI30aaCas8_His6HRV3CCse2_Cas7NLS_Cas5_Cas6

<400>  361
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctcc gaaaaaaaag cgcaaagtgg gtggctctca actggttaaa agcgaactgg     1560

aagagaaaaa aagtgaactg cgccacaaac tgaaatatgt gccgcatgaa tatatcgagc     1620

tgattgaaat tgcacgtaat ccgacccagg atcgtattct ggaaatgaaa gtgatggaat     1680

tttttatgaa agtgtacggc tatcgcggtg aacatctggg tggtagccgt aaaccggatg     1740

gtgcaattta taccgttggt agcccgattg attatggtgt tattgttgat accaaagcct     1800

atagcggtgg ttataatctg ccgattggtc aggcagatga aatgcagcgt tatgtggaag     1860

aaaatcagac ccgtaacaaa catattaatc cgaatgaatg gtggaaagtt tatccgagca     1920

gcgttaccga gtttaaattc ctgtttgtta gcggtcactt caaaggcaac tataaagcac     1980

agctgacccg tctgaatcat attaccaatt gtaatggtgc agttctgagc gttgaagaac     2040

tgctgattgg tggtgaaatg attaaagcag gcaccctgac cctggaagaa gttcgtcgca     2100

aatttaacaa tggcgaaatc aacttttcag gcagcgaaac gccgggtaca agtgagtcag     2160

caactccaga gagcggcggc agtggtagta gtgggggatc tgggtcatct ggtgggatga     2220

atttgcttat tgataactgg attcctgtac gcccgcgaaa cggggggaaa gtccaaatca     2280

taaatctgca atcgctatac tgcagtagag atcagtggcg attaagtttg ccccgtgacg     2340

atatggaact ggccgcttta gcactgctgg tttgcattgg gcaaattatc gccccggcaa     2400

aagatgacgt tgaatttcga catcgcataa tgaatccgct cactgaagat gagtttcaac     2460

aactcatcgc gccgtggata gatatgttct accttaatca cgcagaacat ccctttatgc     2520

agaccaaagg tgtcaaagca aatgatgtga ctccaatgga aaaactgttg gctggggtaa     2580

gcggcgcgac gaattgtgca tttgtcaatc aaccggggca gggtgaagca ttatgtggtg     2640

gatgcactgc gattgcgtta ttcaaccagg cgaatcaggc accaggtttt ggtggtggtt     2700

ttaaaagcgg tttacgtgga ggaacacctg taacaacgtt cgtacgtggg atcgatcttc     2760

gttcaacggt gttactcaat gtcctcacat tacctcgtct tcaaaaacaa tttcctaatg     2820

aatcacatac ggaaaaccaa cctacctgga ttaaacctat caagtccaat gagtctatac     2880

ctgcttcgtc aattgggttt gtccgtggtc tattctggca accagcgcat attgaattat     2940

gcgatcccat tgggattggt aaatgttctt gctgtggaca ggaaagcaat ttgcgttata     3000

ccggttttct taaggaaaaa tttaccttta cagttaatgg gctatggccc catccgcatt     3060

ccccttgtct ggtaacagtc aagaaagggg aggttgagga aaaatttctt gctttcacca     3120

cctccgcacc atcatggaca caaatcagcc gagttgtggt agataagatt attcaaaatg     3180

aaaatggaaa tcgcgtggcg gcggttgtga atcaattcag aaatattgcg ccgcaaagtc     3240

ctcttgaatt gattatgggg ggatatcgta ataatcaagc atctattctt gaacggcgtc     3300

atgatgtgtt gatgtttaat caggggtggc aacaatacgg caatgtgata aacgaaatag     3360

tgactgttgg tttgggatat aaaacagcct tacgcaaggc gttatatacc tttgcagaag     3420

ggtttaaaaa taaagacttc aaaggggccg gagtctctgt tcatgagact gcagaaaggc     3480

atttctatcg acagagtgaa ttattaattc ccgatgtact ggcgaatgtt aatttttccc     3540

aggctgatga ggtaatagct gatttacgag acaaacttca tcaattgtgt gaaatgctat     3600

ttaatcaatc tgtagctccc tatgcacatc atcctaaatt aataagcaca ttagcgcttg     3660

cccgcgccac gctatacaaa catttacggg agttaaaacc gcaaggaggg ccatcaaatg     3720

gctgagcatc accaccatca tcacggtgca cttgaagtcc tctttcaggg acccgggtac     3780

cagatggctg atgaaattga tgcaatggct ttatatcgag cctggcaaca actggataat     3840

ggatcatgtg cgcaaattag acgtgtttca gaacctgatg aattacgcga tatccctgcg     3900

ttttataggc tggtgcaacc ttttggttgg gaaaacccac gtcaccagca ggctcttttg     3960

cgcatggtgt tttgcctgag cgcaggaaag aatgtcatcc gacatcagga caaaaaatcg     4020

gagcaaacaa caggtatctc gttgggaaga gctttagcca atagtggaag aattaacgag     4080

cgccgtatct ttcaattaat tcgggctgac agaacagccg atatggtcca gttacgtcga     4140

ttacttactc acgccgaacc cgtacttgac tggccattaa tggccaggat gttgacctgg     4200

tggggaaagc gcgaacgcca gcaacttctg gaagattttg tattgaccac aaacaaaaat     4260

gcgtaaggaa acctttctat gtctaacttt atcaatattc atgttctgat ctctcacagc     4320

ccttcatgtc tgaaccgcga cgatatgaac atgcagaaag acgctatttt cggcggcaaa     4380

agacgagtaa gaatttcaag tcaaagcctt aaacgtgcga tgcgtaaaag tggttattac     4440

gcacaaaata ttggtgaatc cagtctcaga accattcatc ttgcacaatt acgtgatgtt     4500

cttcggcaaa aacttggtga acgttttgac caaaaaatca tcgataagac attagcgctg     4560

ctctccggta aatcagttga tgaagccgaa aagatttctg ccgatgcggt tactccctgg     4620

gttgtgggag aaatagcctg gttctgtgag caggttgcaa aagcagaggc tgataatctg     4680

gatgataaaa agctgctcaa agttcttaag gaagatattg ccgccatacg tgtgaattta     4740

cagcagggtg ttgatattgc gcttagtgga agaatggcaa ccagcggcat gatgactgag     4800

ttgggaaaag ttgatggtgc aatgtccatt gcgcatgcga tcactactca tcaggttgat     4860

tctgatattg actggttcac cgctgtagat gatttacagg aacaaggttc tgcacatctg     4920

ggaactcagg aattttcatc gggtgttttt tatcgttatg ccaacattaa cctcgctcaa     4980

cttcaggaaa atttaggtgg tgcctccagg gagcaggctc tggaaattgc aacccatgtt     5040

gttcatatgc tggcaacaga ggtccctgga gcaaaacagc gtacttatgc cgcttttaac     5100

cctgcggata tggtaatggt taatttctcc gatatgccac tttctatggc aaatgctttt     5160

gaaaaagcgg ttaaagcgaa agatggcttt ttgcaaccgt ctatacaggc gtttaatcaa     5220

tattgggatc gcgttgccaa tggatatggt ctgaacggag ctgctgcgca attcagctta     5280

tctgatgtag acccaattac tgctcaagtt aaacaaatgc ctactttaga acagttaaaa     5340

tcctgggttc gtaataatgg cgaggcgggc ggtagcccaa agaaaaaacg taaggtttga     5400

taaaggaggt atataatgag atcttatttg atcttgcggc ttgctgggcc aatgcaagcc     5460

tgggggcagc cgacctttga aggaacgcga cctaccggaa gatttccgac ccgaagcggg     5520

ttattagggc tactcggggc ttgtcttggg atccaacgtg atgatacttc ttcattacag     5580

gcgttatcag agagtgtgca atttgcagtg cgctgcgatg aactcattct tgacgatcgt     5640

cgtgtgtctg taacggggtt gcgtgattac catacagtcc ttggagcgcg agaagattac     5700

cgtggtttga aaagtcatga aacgattcaa acatggcgcg aatatttatg tgatgcctcc     5760

tttaccgtcg ctctctggtt aacaccccat gcaacgatgg ttatctcaga acttgaaaaa     5820

gcagtattaa agcctcggta tacaccttac ctggggcgga gaagttgccc actaacacac     5880

ccgctttttt tggggacatg tcaggcatcg gatcctcaga aggcgctatt aaattatgag     5940

cccgttggcg gcgatatata tagtgaggaa tcagttacag ggcatcattt aaaatttacg     6000

gcgcgcgacg aaccgatgat caccttgcct cgacaatttg cttcccgaga atggtatgtg     6060

attaaaggag gtatggatgt atctcagtaa agtcatcatt gccagggcct ggagcaggga     6120

tctttaccaa cttcaccagg gattatggca tttatttcca aacagaccgg atgctgctcg     6180

tgattttctt tttcatgttg agaagcgaaa cacaccagaa ggctgtcatg ttttattgca     6240

gtcagcgcaa atgcctgttt caactgccgt tgcgacagtc attaaaacta aacaggttga     6300

atttcaactt caggttggtg ttccactcta ttttcggctt cgggcaaatc cgatcaaaac     6360

tattctcgac aatcaaaagc gcctggacag taaagggaat attaaacgct gtcgggttcc     6420

gttaataaaa gaagcagaac aaatcgcgtg gttgcaacgt aaattgggca atgcggcgcg     6480

cgttgaagat gtgcatccca tatcggaacg gccacagtat ttttctggtg atggtaaaag     6540

tggaaagatc caaacggttt gctttgaagg tgtgctcacc atcaacgacg cgccagcgtt     6600

aatagatctt gtacagcaag gtattgggcc agctaaatcg atgggatgtg gcttgctatc     6660

tttggctcca ctgtgactgc aggcggccgc actcgagtct ggtaaagaaa ccgctgctgc     6720

gaaatttgaa cgccagcaca tggactcgtc tactagcgca gcttaattaa cctaggctgc     6780

tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg tcttgagggg     6840

ttttttgctg aaacctcagg catttgagaa gcacacggtc acactgcttc cggtagtcaa     6900

taaaccggta aaccagcaat agacataagc ggctatttaa cgaccctgcc ctgaaccgac     6960

gaccgggtca tcgtggccgg atcttgcggc ccctcggctt gaacgaattg ttagacatta     7020

tttgccgact accttggtga tctcgccttt cacgtagtgg acaaattctt ccaactgatc     7080

tgcgcgcgag gccaagcgat cttcttcttg tccaagataa gcctgtctag cttcaagtat     7140

gacgggctga tactgggccg gcaggcgctc cattgcccag tcggcagcga catccttcgg     7200

cgcgattttg ccggttactg cgctgtacca aatgcgggac aacgtaagca ctacatttcg     7260

ctcatcgcca gcccagtcgg gcggcgagtt ccatagcgtt aaggtttcat ttagcgcctc     7320

aaatagatcc tgttcaggaa ccggatcaaa gagttcctcc gccgctggac ctaccaaggc     7380

aacgctatgt tctcttgctt ttgtcagcaa gatagccaga tcaatgtcga tcgtggctgg     7440

ctcgaagata cctgcaagaa tgtcattgcg ctgccattct ccaaattgca gttcgcgctt     7500

agctggataa cgccacggaa tgatgtcgtc gtgcacaaca atggtgactt ctacagcgcg     7560

gagaatctcg ctctctccag gggaagccga agtttccaaa aggtcgttga tcaaagctcg     7620

ccgcgttgtt tcatcaagcc ttacggtcac cgtaaccagc aaatcaatat cactgtgtgg     7680

cttcaggccg ccatccactg cggagccgta caaatgtacg gccagcaacg tcggttcgag     7740

atggcgctcg atgacgccaa ctacctctga tagttgagtc gatacttcgg cgatcaccgc     7800

ttccctcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     7860

gagcggatac atatttgaat gtatttagaa aaataaacaa atagctagct cactcggtcg     7920

ctacgctccg ggcgtgagac tgcggcgggc gctgcggaca catacaaagt tacccacaga     7980

ttccgtggat aagcagggga ctaacatgtg aggcaaaaca gcagggccgc gccggtggcg     8040

tttttccata ggctccgccc tcctgccaga gttcacataa acagacgctt ttccggtgca     8100

tctgtgggag ccgtgaggct caaccatgaa tctgacagta cgggcgaaac ccgacaggac     8160

ttaaagatcc ccaccgtttc cggcgggtcg ctccctcttg cgctctcctg ttccgaccct     8220

gccgtttacc ggatacctgt tccgcctttc tcccttacgg gaagtgtggc gctttctcat     8280

agctcacaca ctggtatctc ggctcggtgt aggtcgttcg ctccaagctg ggctgtaagc     8340

aagaactccc cgttcagccc gactgctgcg ccttatccgg taactgttca cttgagtcca     8400

acccggaaaa gcacggtaaa acgccactgg cagcagccat tggtaactgg gagttcgcag     8460

aggatttgtt tagctaaaca cgcggttgct cttgaagtgt gcgccaaagt ccggctacac     8520

tggaaggaca gatttggttg ctgtgctctg cgaaagccag ttaccacggt taagcagttc     8580

cccaactgac ttaaccttcg atcaaaccac ctccccaggt ggttttttcg tttacagggc     8640

aaaagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatc                   8687


<210>  362
<211>  8614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_His6HRV3CCse2_Cas7_Cas5_Cas620aaFokI

<400>  362
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctaa tttgcttatt gataactgga tccctgtacg cccgcgaaac ggggggaaag     1560

tccaaatcat aaatctgcaa tcgctatact gcagtagaga tcagtggcga ttaagtttgc     1620

cccgtgacga tatggaactg gccgctttag cactgctggt ttgcattggg caaattatcg     1680

ccccggcaaa agatgacgtt gaatttcgac atcgcataat gaatccgctc actgaagatg     1740

agtttcaaca actcatcgcg ccgtggatag atatgttcta ccttaatcac gcagaacatc     1800

cctttatgca gaccaaaggt gtcaaagcaa atgatgtgac tccaatggaa aaactgttgg     1860

ctggggtaag cggcgcgacg aattgtgcat ttgtcaatca accggggcag ggtgaagcat     1920

tatgtggtgg atgcactgcg attgcgttat tcaaccaggc gaatcaggca ccaggttttg     1980

gtggtggttt taaaagcggt ttacgtggag gaacacctgt aacaacgttc gtacgtggga     2040

tcgatcttcg ttcaacggtg ttactcaatg tcctcacatt acctcgtctt caaaaacaat     2100

ttcctaatga atcacatacg gaaaaccaac ctacctggat taaacctatc aagtccaatg     2160

agtctatacc tgcttcgtca attgggtttg tccgtggtct attctggcaa ccagcgcata     2220

ttgaattatg cgatcccatt gggattggta aatgttcttg ctgtggacag gaaagcaatt     2280

tgcgttatac cggttttctt aaggaaaaat ttacctttac agttaatggg ctatggcccc     2340

atccgcattc cccttgtctg gtaacagtca agaaagggga ggttgaggaa aaatttcttg     2400

ctttcaccac ctccgcacca tcatggacac aaatcagccg agttgtggta gataagatta     2460

ttcaaaatga aaatggaaat cgcgtggcgg cggttgtgaa tcaattcaga aatattgcgc     2520

cgcaaagtcc tcttgaattg attatggggg gatatcgtaa taatcaagca tctattcttg     2580

aacggcgtca tgatgtgttg atgtttaatc aggggtggca acaatacggc aatgtgataa     2640

acgaaatagt gactgttggt ttgggatata aaacagcctt acgcaaggcg ttatatacct     2700

ttgcagaagg gtttaaaaat aaagacttca aaggggccgg agtctctgtt catgagactg     2760

cagaaaggca tttctatcga cagagtgaat tattaattcc cgatgtactg gcgaatgtta     2820

atttttccca ggctgatgag gtaatagctg atttacgaga caaacttcat caattgtgtg     2880

aaatgctatt taatcaatct gtagctccct atgcacatca tcctaaatta ataagcacat     2940

tagcgcttgc ccgcgccacg ctatacaaac atttacggga gttaaaaccg caaggagggc     3000

catcaaatgg ctgagcatca ccaccatcat cacggtgcac ttgaagtcct ctttcaggga     3060

cccgggtacc agatggctga tgaaattgat gcaatggctt tatatcgagc ctggcaacaa     3120

ctggataatg gatcatgtgc gcaaattaga cgtgtttcag aacctgatga attacgcgat     3180

atccctgcgt tttataggct ggtgcaacct tttggttggg aaaacccacg tcaccagcag     3240

gctcttttgc gcatggtgtt ttgcctgagc gcaggaaaga atgtcatccg acatcaggac     3300

aaaaaatcgg agcaaacaac aggtatctcg ttgggaagag ctttagccaa tagtggaaga     3360

attaacgagc gccgtatctt tcaattaatt cgggctgaca gaacagccga tatggtccag     3420

ttacgtcgat tacttactca cgccgaaccc gtacttgact ggccattaat ggccaggatg     3480

ttgacctggt ggggaaagcg cgaacgccag caacttctgg aagattttgt attgaccaca     3540

aacaaaaatg cgtaaggaaa cctttctatg tctaacttta tcaatattca tgttctgatc     3600

tctcacagcc cttcatgtct gaaccgcgac gatatgaaca tgcagaaaga cgctattttc     3660

ggcggcaaaa gacgagtaag aatttcaagt caaagcctta aacgtgcgat gcgtaaaagt     3720

ggttattacg cacaaaatat tggtgaatcc agtctcagaa ccattcatct tgcacaatta     3780

cgtgatgttc ttcggcaaaa acttggtgaa cgttttgacc aaaaaatcat cgataagaca     3840

ttagcgctgc tctccggtaa atcagttgat gaagccgaaa agatttctgc cgatgcggtt     3900

actccctggg ttgtgggaga aatagcctgg ttctgtgagc aggttgcaaa agcagaggct     3960

gataatctgg atgataaaaa gctgctcaaa gttcttaagg aagatattgc cgccatacgt     4020

gtgaatttac agcagggtgt tgatattgcg cttagtggaa gaatggcaac cagcggcatg     4080

atgactgagt tgggaaaagt tgatggtgca atgtccattg cgcatgcgat cactactcat     4140

caggttgatt ctgatattga ctggttcacc gctgtagatg atttacagga acaaggttct     4200

gcacatctgg gaactcagga attttcatcg ggtgtttttt atcgttatgc caacattaac     4260

ctcgctcaac ttcaggaaaa tttaggtggt gcctccaggg agcaggctct ggaaattgca     4320

acccatgttg ttcatatgct ggcaacagag gtccctggag caaaacagcg tacttatgcc     4380

gcttttaacc ctgcggatat ggtaatggtt aatttctccg atatgccact ttctatggca     4440

aatgcttttg aaaaagcggt taaagcgaaa gatggctttt tgcaaccgtc tatacaggcg     4500

tttaatcaat attgggatcg cgttgccaat ggatatggtc tgaacggagc tgctgcgcaa     4560

ttcagcttat ctgatgtaga cccaattact gctcaagtta aacaaatgcc tactttagaa     4620

cagttaaaat cctgggttcg taataatggc gaggcgtgaa catgagatct tatttgatct     4680

tgcggcttgc tgggccaatg caagcctggg ggcagccgac ctttgaagga acgcgaccta     4740

ccggaagatt tccgacccga agcgggttat tagggctact cggggcttgt cttgggatcc     4800

aacgtgatga tacttcttca ttacaggcgt tatcagagag tgtgcaattt gcagtgcgct     4860

gcgatgaact cattcttgac gatcgtcgtg tgtctgtaac ggggttgcgt gattaccata     4920

cagtccttgg agcgcgagaa gattaccgtg gtttgaaaag tcatgaaacg attcaaacat     4980

ggcgcgaata tttatgtgat gcctccttta ccgtcgctct ctggttaaca ccccatgcaa     5040

cgatggttat ctcagaactt gaaaaagcag tattaaagcc tcggtataca ccttacctgg     5100

ggcggagaag ttgcccacta acacacccgc tttttttggg gacatgtcag gcatcggatc     5160

ctcagaaggc gctattaaat tatgagcccg ttggcggcga tatatatagt gaggaatcag     5220

ttacagggca tcatttaaaa tttacggcgc gcgacgaacc gatgatcacc ttgcctcgac     5280

aatttgcttc ccgagaatgg tatgtgatta aaggaggtat ggatgtatct cagtaaagtc     5340

atcattgcca gggcctggag cagggatctt taccaacttc accagggatt atggcattta     5400

tttccaaaca gaccggatgc tgctcgtgat tttctttttc atgttgagaa gcgaaacaca     5460

ccagaaggct gtcatgtttt attgcagtca gcgcaaatgc ctgtttcaac tgccgttgcg     5520

acagtcatta aaactaaaca ggttgaattt caacttcagg ttggtgttcc actctatttt     5580

cggcttcggg caaatccgat caaaactatt ctcgacaatc aaaagcgcct ggacagtaaa     5640

gggaatatta aacgctgtcg ggttccgtta ataaaagaag cagaacaaat cgcgtggttg     5700

caacgtaaat tgggcaatgc ggcgcgcgtt gaagatgtgc atcccatatc ggaacggcca     5760

cagtattttt ctggtgatgg taaaagtgga aagatccaaa cggtttgctt tgaaggtgtg     5820

ctcaccatca acgacgcgcc agcgttaata gatcttgtac agcaaggtat tgggccagct     5880

aaatcgatgg gatgtggctt gctatctttg gctccactgt cgggctcaga aacgccgggg     5940

acatcggaat ccgccacacc tgagtcgggt ggttctggtc aactggttaa aagcgaactg     6000

gaagagaaaa aaagtgaact gcgccacaaa ctgaaatatg tgccgcatga atatatcgag     6060

ctgattgaaa ttgcacgtaa tccgacccag gatcgtattc tggaaatgaa agtgatggaa     6120

ttttttatga aagtgtacgg ctatcgcggt gaacatctgg gtggtagccg taaaccggat     6180

ggtgcaattt ataccgttgg tagcccgatt gattatggtg ttattgttga taccaaagcc     6240

tatagcggtg gttataatct gccgattggt caggcagatg aaatgcagcg ttatgtggaa     6300

gaaaatcaga cccgtaacaa acatattaat ccgaatgaat ggtggaaagt ttatccgagc     6360

agcgttaccg agtttaaatt cctgtttgtt agcggtcact tcaaaggcaa ctataaagca     6420

cagctgaccc gtctgaatca tattaccaat tgtaatggtg cagttctgag cgttgaagaa     6480

ctgctgattg gtggtgaaat gattaaagca ggcaccctga ccctggaaga agttcgtcgc     6540

aaatttaaca atggcgaaat caactttggt ggctctccga aaaaaaagcg caaagtgtaa     6600

taactgcagg cggccgcact cgagtctggt aaagaaaccg ctgctgcgaa atttgaacgc     6660

cagcacatgg actcgtctac tagcgcagct taattaacct aggctgctgc caccgctgag     6720

caataactag cataacccct tggggcctct aaacgggtct tgaggggttt tttgctgaaa     6780

cctcaggcat ttgagaagca cacggtcaca ctgcttccgg tagtcaataa accggtaaac     6840

cagcaataga cataagcggc tatttaacga ccctgccctg aaccgacgac cgggtcatcg     6900

tggccggatc ttgcggcccc tcggcttgaa cgaattgtta gacattattt gccgactacc     6960

ttggtgatct cgcctttcac gtagtggaca aattcttcca actgatctgc gcgcgaggcc     7020

aagcgatctt cttcttgtcc aagataagcc tgtctagctt caagtatgac gggctgatac     7080

tgggccggca ggcgctccat tgcccagtcg gcagcgacat ccttcggcgc gattttgccg     7140

gttactgcgc tgtaccaaat gcgggacaac gtaagcacta catttcgctc atcgccagcc     7200

cagtcgggcg gcgagttcca tagcgttaag gtttcattta gcgcctcaaa tagatcctgt     7260

tcaggaaccg gatcaaagag ttcctccgcc gctggaccta ccaaggcaac gctatgttct     7320

cttgcttttg tcagcaagat agccagatca atgtcgatcg tggctggctc gaagatacct     7380

gcaagaatgt cattgcgctg ccattctcca aattgcagtt cgcgcttagc tggataacgc     7440

cacggaatga tgtcgtcgtg cacaacaatg gtgacttcta cagcgcggag aatctcgctc     7500

tctccagggg aagccgaagt ttccaaaagg tcgttgatca aagctcgccg cgttgtttca     7560

tcaagcctta cggtcaccgt aaccagcaaa tcaatatcac tgtgtggctt caggccgcca     7620

tccactgcgg agccgtacaa atgtacggcc agcaacgtcg gttcgagatg gcgctcgatg     7680

acgccaacta cctctgatag ttgagtcgat acttcggcga tcaccgcttc cctcatactc     7740

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     7800

tttgaatgta tttagaaaaa taaacaaata gctagctcac tcggtcgcta cgctccgggc     7860

gtgagactgc ggcgggcgct gcggacacat acaaagttac ccacagattc cgtggataag     7920

caggggacta acatgtgagg caaaacagca gggccgcgcc ggtggcgttt ttccataggc     7980

tccgccctcc tgccagagtt cacataaaca gacgcttttc cggtgcatct gtgggagccg     8040

tgaggctcaa ccatgaatct gacagtacgg gcgaaacccg acaggactta aagatcccca     8100

ccgtttccgg cgggtcgctc cctcttgcgc tctcctgttc cgaccctgcc gtttaccgga     8160

tacctgttcc gcctttctcc cttacgggaa gtgtggcgct ttctcatagc tcacacactg     8220

gtatctcggc tcggtgtagg tcgttcgctc caagctgggc tgtaagcaag aactccccgt     8280

tcagcccgac tgctgcgcct tatccggtaa ctgttcactt gagtccaacc cggaaaagca     8340

cggtaaaacg ccactggcag cagccattgg taactgggag ttcgcagagg atttgtttag     8400

ctaaacacgc ggttgctctt gaagtgtgcg ccaaagtccg gctacactgg aaggacagat     8460

ttggttgctg tgctctgcga aagccagtta ccacggttaa gcagttcccc aactgactta     8520

accttcgatc aaaccacctc cccaggtggt tttttcgttt acagggcaaa agattacgcg     8580

cagaaaaaaa ggatctcaag aagatccttt gatc                                 8614


<210>  363
<211>  12975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polypromoter, Cas5_Cas3_Cse2_Cas7_Cas6_Cas8_CRISPR(J3)

<400>  363
ggcaccatgc atcgatcccg cgaaatgcgg ccgcttaatt aaggcatcaa ataaaacgaa       60

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca      120

gtctgggcga aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt      180

ttgcgtttct atcgatcccg cgaaattaat acgactcact ataggcccct ctagaaataa      240

ttttgtttaa ctttaagctt taagaaggag atatagatca tgagatctta tttgatcttg      300

cggcttgctg ggccaatgca agcctggggg cagccgacct ttgaaggaac gcgacctacc      360

ggaagatttc cgacccgaag cgggttatta gggctactcg gggcttgtct tgggatccaa      420

cgtgatgata cttcttcatt acaggcgtta tcagagagtg tgcaatttgc agtgcgctgc      480

gatgaactca ttcttgacga tcgtcgtgtg tctgtaacgg ggttgcgtga ttaccataca      540

gtccttggag cgcgagaaga ttaccgtggt ttgaaaagtc atgaaacgat tcaaacatgg      600

cgcgaatatt tatgtgatgc ctcctttacc gtcgctctct ggttaacacc ccatgcaacg      660

atggttatct cagaacttga aaaagcagta ttaaagcctc ggtatacacc ttacctgggg      720

cggagaagtt gcccactaac acacccgctt tttttgggga catgtcaggc atcggatcct      780

cagaaggcgc tattaaatta tgagcccgtt ggcggcgata tatatagtga ggaatcagtt      840

acagggcatc atttaaaatt tacggcgcgc gacgaaccga tgatcacctt gcctcgacaa      900

tttgcttccc gagaatggta tgtgattaaa ggaggtatgg atgtatctca gtaataataa      960

gatcccaact ccataagtgg ctgctgccac cgctgagcat agcataaccc cttggggcct     1020

ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatcaagt cccgaagtag     1080

ctgtcagact gctggcgacc gccgcaacta gtggcgtcat gcgtgccgta tggtctttcg     1140

cctgtagacg ccctacaagc cgtactaaag tggaaagacc cgcaaaaggt atcgcgatta     1200

aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttgt     1260

ttgtcggtga gtccttccag tctgggcgaa agcgcggtcg atcaaattaa gcagaaggcc     1320

atcctgacgg atggcctttt tgcgtttcta tcgatcccgc gaaattaata cgactcacta     1380

taggcccctc tagaaataat tttgtttaac tttaagcttt aagaaggaga tatagatcat     1440

ggaacctttt aaatatatat gccattactg gggaaaatcc tcaaaaagct tgacgaaagg     1500

aaatgatatt catctgttaa tttatcattg ccttgatgtt gctgctgttg cagattgctg     1560

gtgggatcaa tcagtcgtac tgcaaaatac tttttgccga aatgaaatgc tatcaaaaca     1620

gagggtgaag gcctggctgt tatttttcat tgctcttcat gatattggaa agtttgatat     1680

acgattccaa tataaatcag cagaaagttg gctgaaatta aatcctgcaa cgccatcact     1740

taatggtcca tcaacacaaa tgtgccgtaa atttaatcat ggtgcagccg gtctgtattg     1800

gtttaaccag gattcacttt cagagcaatc tctcggggat tttttcagtt tttttgatgc     1860

cgctcctcat ccttatgagt cctggtttcc atgggtagag gccgttacag gacatcatgg     1920

ttttatatta cattcccagg atcaagataa gtcgcgttgg gaaatgccag cttctctggc     1980

atcttatgct gcgcaagata aacaggctcg tgaggagtgg atatctgtac tggaagcatt     2040

atttttaacg ccagcggggt tatctataaa cgatatacca cctgattgtt catcactgtt     2100

agcaggtttt tgctcgcttg ctgactggtt aggctcctgg actacaacga atacctttct     2160

gtttaatgag gatgcgcctt ccgacataaa tgctctgaga acgtatttcc aggaccgaca     2220

gcaggatgcg agccgggtat tggagttgag tggacttgta tcaaataagc gatgttatga     2280

aggtgttcat gcactactgg acaatggcta tcaacccaga caattacagg tgttagttga     2340

tgctcttcca gtagctcccg ggctgacggt aatagaggca cctacaggct ccggtaaaac     2400

ggaaacagcg ctggcctatg cttggaaact tattgatcaa caaattgcgg atagtgttat     2460

ttttgccctc ccaacacaag ctaccgcgaa tgctatgctt acgagaatgg aagcgagcgc     2520

gagccactta ttttcatccc caaatcttat tcttgctcat ggcaattcac ggtttaacca     2580

cctctttcaa tcaataaaat cacgcgcgat tactgaacag gggcaagaag aagcgtgggt     2640

tcagtgttgt cagtggttgt cacaaagcaa taagaaagtg tttcttgggc aaatcggcgt     2700

ttgcacgatt gatcaggtgt tgatatcggt attgccagtt aaacaccgct ttatccgtgg     2760

tttgggaatt ggtcgaagtg ttttaattgt tgatgaagtt catgcttacg acacctatat     2820

gaacggcttg ctggaggcag tgctcaaggc tcaggctgat gtgggaggga gtgttattct     2880

tctttccgca accctaccaa tgaaacaaaa acagaaactt ctggatactt atggtctgca     2940

tacagatcca gtggaaaata actccgcata tccactcatt aactggcgag gtgtgaatgg     3000

tgcgcaacgt tttgatctgc tagctcatcc agaacaactc ccgccccgct tttcgattca     3060

gccagaacct atttgtttag ctgacatgtt acctgacctt acgatgttag agcgaatgat     3120

cgcagcggca aacgcgggtg cacaggtctg tcttatttgc aatttggttg acgttgcaca     3180

agtatgctac caacggctaa aggagctaaa taacacgcaa gtagatatag atttgtttca     3240

tgcgcgcttt acgctgaacg atcgtcgtga aaaagagaat cgagttatta gcaatttcgg     3300

caaaaatggg aagcgaaatg ttggacggat acttgtcgca acccaggtcg tggaacaatc     3360

actcgacgtt gattttgatt ggttaattac tcagcattgt cctgcagatt tgcttttcca     3420

acgattgggc cgtttacatc gccatcatcg caaatatcgt cccgctggtt ttgagattcc     3480

tgttgccacc attttgctgc ctgatggcga gggttacgga cgacatgagc atatttatag     3540

caacgttaga gtcatgtggc ggacgcagca acatattgag gagcttaatg gagcatcctt     3600

atttttccct gatgcttacc ggcaatggct ggatagcatt tacgatgatg cggaaatgga     3660

tgagccagaa tgggtcggca atggcatgga taaatttgaa agcgccgagt gtgaaaaaag     3720

gttcaaggct cgcaaggtcc tgcagtgggc tgaagaatat agcttgcagg ataacgatga     3780

aaccattctt gcggtaacga gggatgggga aatgagcctg ccattattgc cttatgtaca     3840

aacgtcttca ggtaaacaac tgctcgatgg ccaggtctac gaggacctaa gtcatgaaca     3900

gcagtatgag gcgcttgcac ttaatcgcgt caatgtaccc ttcacctgga aacgtagttt     3960

ttctgaagta gtagatgaag atgggttact ttggctggaa gggaaacaga atctggatgg     4020

atgggtctgg cagggtaaca gtattgttat tacctataca ggggatgaag ggatgaccag     4080

agtcatccct gcaaatccca aataataata agatcccaac tccataagtg gctgctgcca     4140

ccgctgagca tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgctg     4200

aaaggaggaa ctatatcaag tcccgaagta gctgtcagac tgctggcgac cgccgcaact     4260

agtggcgtca tgcgtgccgt atggtctttc gcctgtagac gccctacaag ccgtactaaa     4320

gtggaaagac ccgcaaaagg tatcgcgatt aaggcatcaa ataaaacgaa aggctcagtc     4380

gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca gtctgggcga     4440

aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt ttgcgtttct     4500

atcgatcccg cgaaattaat acgactcact ataggcccct ctagaaataa ttttgtttaa     4560

ctttaagctt taagaaggag atatagatca tggctgatga aattgatgca atggctttat     4620

atcgagcctg gcaacaactg gataatggat catgtgcgca aattagacgt gtttcagaac     4680

ctgatgaatt acgcgatatc cctgcgtttt ataggctggt gcaacctttt ggttgggaaa     4740

acccacgtca ccagcaggct cttttgcgca tggtgttttg cctgagcgca ggaaagaatg     4800

tcatccgaca tcaggacaaa aaatcggagc aaacaacagg tatctcgttg ggaagagctt     4860

tagccaatag tggaagaatt aacgagcgcc gtatctttca attaattcgg gctgacagaa     4920

cagccgatat ggtccagtta cgtcgattac ttactcacgc cgaacccgta cttgactggc     4980

cattaatggc caggatgttg acctggtggg gaaagcgcga acgccagcaa cttctggaag     5040

attttgtatt gaccacaaac aaaaatgcgt aataataaga tcccaactcc ataagtggct     5100

gctgccaccg ctgagcatag cataacccct tggggcctct aaacgggtct tgaggggttt     5160

tttgctgaaa ggaggaacta tatcaagtcc cgaagtagct gtcagactgc tggcgaccgc     5220

cgcaactagt ggcgtcatgc gtgccgtatg gtctttcgcc tgtagacgcc ctacaagccg     5280

tactaaagtg gaaagacccg caaaaggtat cgcgattaag gcatcaaata aaacgaaagg     5340

ctcagtcgaa agactgggcc tttcgtttta tctgttgttt gtcggtgagt ccttccagtc     5400

tgggcgaaag cgcggtcgat caaattaagc agaaggccat cctgacggat ggcctttttg     5460

cgtttctatc gatcccgcga aattaatacg actcactata ggcccctcta gaaataattt     5520

tgtttaactt taagctttaa gaaggagata tagatcatgt ctaactttat caatattcat     5580

gttctgatct ctcacagccc ttcatgtctg aaccgcgacg atatgaacat gcagaaagac     5640

gctattttcg gcggcaaaag acgagtaaga atttcaagtc aaagccttaa acgtgcgatg     5700

cgtaaaagtg gttattacgc acaaaatatt ggtgaatcca gtctcagaac cattcatctt     5760

gcacaattac gtgatgttct tcggcaaaaa cttggtgaac gttttgacca aaaaatcatc     5820

gataagacat tagcgctgct ctccggtaaa tcagttgatg aagccgaaaa gatttctgcc     5880

gatgcggtta ctccctgggt tgtgggagaa atagcctggt tctgtgagca ggttgcaaaa     5940

gcagaggctg ataatctgga tgataaaaag ctgctcaaag ttcttaagga agatattgcc     6000

gccatacgtg tgaatttaca gcagggtgtt gatattgcgc ttagtggaag aatggcaacc     6060

agcggcatga tgactgagtt gggaaaagtt gatggtgcaa tgtccattgc gcatgcgatc     6120

actactcatc aggttgattc tgatattgac tggttcaccg ctgtagatga tttacaggaa     6180

caaggttctg cacatctggg aactcaggaa ttttcatcgg gtgtttttta tcgttatgcc     6240

aacattaacc tcgctcaact tcaggaaaat ttaggtggtg cctccaggga gcaggctctg     6300

gaaattgcaa cccatgttgt tcatatgctg gcaacagagg tccctggagc aaaacagcgt     6360

acttatgccg cttttaaccc tgcggatatg gtaatggtta atttctccga tatgccactt     6420

tctatggcaa atgcttttga aaaagcggtt aaagcgaaag atggcttttt gcaaccgtct     6480

atacaggcgt ttaatcaata ttgggatcgc gttgccaatg gatatggtct gaacggagct     6540

gctgcgcaat tcagcttatc tgatgtagac ccaattactg ctcaagttaa acaaatgcct     6600

actttagaac agttaaaatc ctgggttcgt aataatggcg aggcgtgata ataagatccc     6660

aactccataa gtggctgctg ccaccgctga gcatagcata accccttggg gcctctaaac     6720

gggtcttgag gggttttttg ctgaaaggag gaactatatc aagtcccgaa gtagctgtca     6780

gactgctggc gaccgccgca actagtggcg tcatgcgtgc cgtatggtct ttcgcctgta     6840

gacgccctac aagccgtact aaagtggaaa gacccgcaaa aggtatcgcg attaaggcat     6900

caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttgtttgtcg     6960

gtgagtcctt ccagtctggg cgaaagcgcg gtcgatcaaa ttaagcagaa ggccatcctg     7020

acggatggcc tttttgcgtt tctatcgatc ccgcgaaatt aatacgactc actataggcc     7080

cctctagaaa taattttgtt taactttaag ctttaagaag gagatataga tcatgtatct     7140

cagtaaagtc atcattgcca gggcctggag cagggatctt taccaacttc accagggatt     7200

atggcattta tttccaaaca gaccggatgc tgctcgtgat tttctttttc atgttgagaa     7260

gcgaaacaca ccagaaggct gtcatgtttt attgcagtca gcgcaaatgc ctgtttcaac     7320

tgccgttgcg acagtcatta aaactaaaca ggttgaattt caacttcagg ttggtgttcc     7380

actctatttt cggcttcggg caaatccgat caaaactatt ctcgacaatc aaaagcgcct     7440

ggacagtaaa gggaatatta aacgctgtcg ggttccgtta ataaaagaag cagaacaaat     7500

cgcgtggttg caacgtaaat tgggcaatgc ggcgcgcgtt gaagatgtgc atcccatatc     7560

ggaacggcca cagtattttt ctggtgatgg taaaagtgga aagatccaaa cggtttgctt     7620

tgaaggtgtg ctcaccatca acgacgcgcc agcgttaata gatcttgtac agcaaggtat     7680

tgggccagct aaatcgatgg gatgtggctt gctatctttg gctccactgt gataataaga     7740

tcccaactcc ataagtggct gctgccaccg ctgagcatag cataacccct tggggcctct     7800

aaacgggtct tgaggggttt tttgctgaaa ggaggaacta tatcaagtcc cgaagtagct     7860

gtcagactgc tggcgaccgc cgcaactagt ggcgtcatgc gtgccgtatg gtctttcgcc     7920

tgtagacgcc ctacaagccg tactaaagtg gaaagacccg caaaaggtat cgcgattaag     7980

gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta tctgttgttt     8040

gtcggtgagt ccttccagtc tgggcgaaag cgcggtcgat caaattaagc agaaggccat     8100

cctgacggat ggcctttttg cgtttctatc gatcccgcga aattaatacg actcactata     8160

ggcccctcta gaaataattt tgtttaactt taagctttaa gaaggagata tagatcatga     8220

atttgcttat tgataactgg atccctgtac gcccgcgaaa cggggggaaa gtccaaatca     8280

taaatctgca atcgctatac tgcagtagag atcagtggcg attaagtttg ccccgtgacg     8340

atatggaact ggccgcttta gcactgctgg tttgcattgg gcaaattatc gccccggcaa     8400

aagatgacgt tgaatttcga catcgcataa tgaatccgct cactgaagat gagtttcaac     8460

aactcatcgc gccgtggata gatatgttct accttaatca cgcagaacat ccctttatgc     8520

agaccaaagg tgtcaaagca aatgatgtga ctccaatgga aaaactgttg gctggggtaa     8580

gcggcgcgac gaattgtgca tttgtcaatc aaccggggca gggtgaagca ttatgtggtg     8640

gatgcactgc gattgcgtta ttcaaccagg cgaatcaggc accaggtttt ggtggtggtt     8700

ttaaaagcgg tttacgtgga ggaacacctg taacaacgtt cgtacgtggg atcgatcttc     8760

gttcaacggt gttactcaat gtcctcacat tacctcgtct tcaaaaacaa tttcctaatg     8820

aatcacatac ggaaaaccaa cctacctgga ttaaacctat caagtccaat gagtctatac     8880

ctgcttcgtc aattgggttt gtccgtggtc tattctggca accagcgcat attgaattat     8940

gcgatcccat tgggattggt aaatgttctt gctgtggaca ggaaagcaat ttgcgttata     9000

ccggttttct taaggaaaaa tttaccttta cagttaatgg gctatggccc catccgcatt     9060

ccccttgtct ggtaacagtc aagaaagggg aggttgagga aaaatttctt gctttcacca     9120

cctccgcacc atcatggaca caaatcagcc gagttgtggt agataagatt attcaaaatg     9180

aaaatggaaa tcgcgtggcg gcggttgtga atcaattcag aaatattgcg ccgcaaagtc     9240

ctcttgaatt gattatgggg ggatatcgta ataatcaagc atctattctt gaacggcgtc     9300

atgatgtgtt gatgtttaat caggggtggc aacaatacgg caatgtgata aacgaaatag     9360

tgactgttgg tttgggatat aaaacagcct tacgcaaggc gttatatacc tttgcagaag     9420

ggtttaaaaa taaagacttc aaaggggccg gagtctctgt tcatgagact gcagaaaggc     9480

atttctatcg acagagtgaa ttattaattc ccgatgtact ggcgaatgtt aatttttccc     9540

aggctgatga ggtaatagct gatttacgag acaaacttca tcaattgtgt gaaatgctat     9600

ttaatcaatc tgtagctccc tatgcacatc atcctaaatt aataagcaca ttagcgcttg     9660

cccgcgccac gctatacaaa catttacggg agttaaaacc gcaaggaggg ccatcaaatg     9720

gctgataata agatcccaac tccataagtg gctgctgcca ccgctgagca tagcataacc     9780

ccttggggcc tctaaacggg tcttgagggg ttttttgctg aaaggaggaa ctatatcaag     9840

tcccgaagta gctgtcagac tgctggcgac cgccgcaact agtggcgtca tgcgtgccgt     9900

atggtctttc gcctgtagac gccctacaag ccgtactaaa gtggaaagac ccgcaaaagg     9960

tatcgcgatt aaggcatcaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt    10020

ttatctgttg tttgtcggtg agtccttcca gtctgggcga aagcgcggtc gatcaaatta    10080

agcagaaggc catcctgacg gatggccttt ttgcgtttct atcgatcccg cgaaattaat    10140

acgactcact ataggcccct ctagagctag cgagttcccc gcgccagcgg ggataaaccg    10200

ccagtgataa gtggaatgcc atgtgggctg tcgagttccc cgcgccagcg gggataaacc    10260

ggagctcgct gagcatagca taaccccttg gggcctctaa acgggtcttg aggggttttt    10320

tgctgaaagg aggaactata tcaagtcccg aagtagctgt cagactgctg gcgaccgccg    10380

caactagtgg cgtcatgcgt gccgtatggt ctttcgcctg tagacgccct acaagccgta    10440

ctaaagtgga aagacccgca aaaggtatcg cgatcgccct gcagggaact atatccgact    10500

agtagcccgc ctaatgagcg ggcttttttt taattcccct atttgtttat ttttctaaat    10560

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc gaaaaaggaa    10620

gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct    10680

tcctgttttt gctcacccag aaacgctcgt gaaagtaaaa gacgcagagg accaattggg    10740

ggcacgagtg ggatacatag aactggactt gaatagcggt aaaatccttg agagttttcg    10800

ccctgaagag cgttttccaa tgatgagcac tttcaaagtt ctgctatgtg gagcagtatt    10860

atcccgtgta gatgcggggc aagagcaact cggacgacga atacactatt cgcagaatga    10920

cttggttgaa tactccccag tgacagaaaa gcaccttacg gacggaatga cggtaagaga    10980

attatgtagt gccgccataa cgatgagtga taacactgcg gcgaacttac ttctgacaac    11040

catcggtgga ccgaaggaat taaccgcttt tttgcacaat atgggagacc atgtaactcg    11100

ccttgaccgt tgggaaccag aactgaatga agccatacca aacgacgagc gagacaccac    11160

aatgcctgcg gcaatggcaa caacattacg caaactatta actggcgaac tacttactct    11220

ggcttcacgg caacaattaa tagactggct tgaagcggat aaagttgcag gaccactact    11280

gcgttcggca cttcctgctg gctggtttat tgctgataaa tctggggcag gagagcgtgg    11340

ttcacggggt atcattgccg cacttggacc agatggtaag ccttcccgta tcgtagttat    11400

ctacacgacg ggtagtcagg caactatgga cgaacgaaat agacagattg ctgaaatagg    11460

ggcttcactg attaagcatt ggtaaaccga tacaattaaa ggctcctttt ggagcctttt    11520

tttttggacg gaccggtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc    11580

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat    11640

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat    11700

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct    11760

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt    11820

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg    11880

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta    11940

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg    12000

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg    12060

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc    12120

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg    12180

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat    12240

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc    12300

agcgagtcag tgagcgagga agcggaagag cgcctgatgc ggtattttct ccttacgcat    12360

ctgtgcggta tttcacaccg caatggtgca ctctcagtac aatctgctct gatgccgcat    12420

agttaagcca gtatacactc cgctatcgct acgtgactgg gtcatggctg cgccccgaca    12480

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag    12540

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa    12600

acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg tgaagcgatt cacagatgtc    12660

tgcctgttca tccgcgtcca gctcgttgag tttctccaga agcgttaatg tctggcttct    12720

gataaagcgg gccatgttaa gggcggtttt ttcctgtttg gtcactgatg cctccgtgta    12780

agggggattt ctgttcatgg ggtaatgata ccgatgaaac gagagaggat gctcacgata    12840

cgggttactg atgatgaaca tgcccggtta ctggaacgtt gtgagggtaa acaactggcg    12900

gtatggatgc ggcgggacca gagaaaaatc actcagggtc aatgccagcg cttcgttaat    12960

acagatgtag gtgtt                                                     12975


<210>  364
<211>  12975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polypromoter, Cas5_Cas3_Cse2_Cas7_CRISPR(J3)_Cas6_Cas8

<400>  364
ggcaccatgc atcgatcccg cgaaatgcgg ccgcttaatt aaggcatcaa ataaaacgaa       60

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca      120

gtctgggcga aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt      180

ttgcgtttct atcgatcccg cgaaattaat acgactcact ataggcccct ctagaaataa      240

ttttgtttaa ctttaagctt taagaaggag atatagatca tgagatctta tttgatcttg      300

cggcttgctg ggccaatgca agcctggggg cagccgacct ttgaaggaac gcgacctacc      360

ggaagatttc cgacccgaag cgggttatta gggctactcg gggcttgtct tgggatccaa      420

cgtgatgata cttcttcatt acaggcgtta tcagagagtg tgcaatttgc agtgcgctgc      480

gatgaactca ttcttgacga tcgtcgtgtg tctgtaacgg ggttgcgtga ttaccataca      540

gtccttggag cgcgagaaga ttaccgtggt ttgaaaagtc atgaaacgat tcaaacatgg      600

cgcgaatatt tatgtgatgc ctcctttacc gtcgctctct ggttaacacc ccatgcaacg      660

atggttatct cagaacttga aaaagcagta ttaaagcctc ggtatacacc ttacctgggg      720

cggagaagtt gcccactaac acacccgctt tttttgggga catgtcaggc atcggatcct      780

cagaaggcgc tattaaatta tgagcccgtt ggcggcgata tatatagtga ggaatcagtt      840

acagggcatc atttaaaatt tacggcgcgc gacgaaccga tgatcacctt gcctcgacaa      900

tttgcttccc gagaatggta tgtgattaaa ggaggtatgg atgtatctca gtaataataa      960

gatcccaact ccataagtgg ctgctgccac cgctgagcat agcataaccc cttggggcct     1020

ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatcaagt cccgaagtag     1080

ctgtcagact gctggcgacc gccgcaacta gtggcgtcat gcgtgccgta tggtctttcg     1140

cctgtagacg ccctacaagc cgtactaaag tggaaagacc cgcaaaaggt atcgcgatta     1200

aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttgt     1260

ttgtcggtga gtccttccag tctgggcgaa agcgcggtcg atcaaattaa gcagaaggcc     1320

atcctgacgg atggcctttt tgcgtttcta tcgatcccgc gaaattaata cgactcacta     1380

taggcccctc tagaaataat tttgtttaac tttaagcttt aagaaggaga tatagatcat     1440

ggaacctttt aaatatatat gccattactg gggaaaatcc tcaaaaagct tgacgaaagg     1500

aaatgatatt catctgttaa tttatcattg ccttgatgtt gctgctgttg cagattgctg     1560

gtgggatcaa tcagtcgtac tgcaaaatac tttttgccga aatgaaatgc tatcaaaaca     1620

gagggtgaag gcctggctgt tatttttcat tgctcttcat gatattggaa agtttgatat     1680

acgattccaa tataaatcag cagaaagttg gctgaaatta aatcctgcaa cgccatcact     1740

taatggtcca tcaacacaaa tgtgccgtaa atttaatcat ggtgcagccg gtctgtattg     1800

gtttaaccag gattcacttt cagagcaatc tctcggggat tttttcagtt tttttgatgc     1860

cgctcctcat ccttatgagt cctggtttcc atgggtagag gccgttacag gacatcatgg     1920

ttttatatta cattcccagg atcaagataa gtcgcgttgg gaaatgccag cttctctggc     1980

atcttatgct gcgcaagata aacaggctcg tgaggagtgg atatctgtac tggaagcatt     2040

atttttaacg ccagcggggt tatctataaa cgatatacca cctgattgtt catcactgtt     2100

agcaggtttt tgctcgcttg ctgactggtt aggctcctgg actacaacga atacctttct     2160

gtttaatgag gatgcgcctt ccgacataaa tgctctgaga acgtatttcc aggaccgaca     2220

gcaggatgcg agccgggtat tggagttgag tggacttgta tcaaataagc gatgttatga     2280

aggtgttcat gcactactgg acaatggcta tcaacccaga caattacagg tgttagttga     2340

tgctcttcca gtagctcccg ggctgacggt aatagaggca cctacaggct ccggtaaaac     2400

ggaaacagcg ctggcctatg cttggaaact tattgatcaa caaattgcgg atagtgttat     2460

ttttgccctc ccaacacaag ctaccgcgaa tgctatgctt acgagaatgg aagcgagcgc     2520

gagccactta ttttcatccc caaatcttat tcttgctcat ggcaattcac ggtttaacca     2580

cctctttcaa tcaataaaat cacgcgcgat tactgaacag gggcaagaag aagcgtgggt     2640

tcagtgttgt cagtggttgt cacaaagcaa taagaaagtg tttcttgggc aaatcggcgt     2700

ttgcacgatt gatcaggtgt tgatatcggt attgccagtt aaacaccgct ttatccgtgg     2760

tttgggaatt ggtcgaagtg ttttaattgt tgatgaagtt catgcttacg acacctatat     2820

gaacggcttg ctggaggcag tgctcaaggc tcaggctgat gtgggaggga gtgttattct     2880

tctttccgca accctaccaa tgaaacaaaa acagaaactt ctggatactt atggtctgca     2940

tacagatcca gtggaaaata actccgcata tccactcatt aactggcgag gtgtgaatgg     3000

tgcgcaacgt tttgatctgc tagctcatcc agaacaactc ccgccccgct tttcgattca     3060

gccagaacct atttgtttag ctgacatgtt acctgacctt acgatgttag agcgaatgat     3120

cgcagcggca aacgcgggtg cacaggtctg tcttatttgc aatttggttg acgttgcaca     3180

agtatgctac caacggctaa aggagctaaa taacacgcaa gtagatatag atttgtttca     3240

tgcgcgcttt acgctgaacg atcgtcgtga aaaagagaat cgagttatta gcaatttcgg     3300

caaaaatggg aagcgaaatg ttggacggat acttgtcgca acccaggtcg tggaacaatc     3360

actcgacgtt gattttgatt ggttaattac tcagcattgt cctgcagatt tgcttttcca     3420

acgattgggc cgtttacatc gccatcatcg caaatatcgt cccgctggtt ttgagattcc     3480

tgttgccacc attttgctgc ctgatggcga gggttacgga cgacatgagc atatttatag     3540

caacgttaga gtcatgtggc ggacgcagca acatattgag gagcttaatg gagcatcctt     3600

atttttccct gatgcttacc ggcaatggct ggatagcatt tacgatgatg cggaaatgga     3660

tgagccagaa tgggtcggca atggcatgga taaatttgaa agcgccgagt gtgaaaaaag     3720

gttcaaggct cgcaaggtcc tgcagtgggc tgaagaatat agcttgcagg ataacgatga     3780

aaccattctt gcggtaacga gggatgggga aatgagcctg ccattattgc cttatgtaca     3840

aacgtcttca ggtaaacaac tgctcgatgg ccaggtctac gaggacctaa gtcatgaaca     3900

gcagtatgag gcgcttgcac ttaatcgcgt caatgtaccc ttcacctgga aacgtagttt     3960

ttctgaagta gtagatgaag atgggttact ttggctggaa gggaaacaga atctggatgg     4020

atgggtctgg cagggtaaca gtattgttat tacctataca ggggatgaag ggatgaccag     4080

agtcatccct gcaaatccca aataataata agatcccaac tccataagtg gctgctgcca     4140

ccgctgagca tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgctg     4200

aaaggaggaa ctatatcaag tcccgaagta gctgtcagac tgctggcgac cgccgcaact     4260

agtggcgtca tgcgtgccgt atggtctttc gcctgtagac gccctacaag ccgtactaaa     4320

gtggaaagac ccgcaaaagg tatcgcgatt aaggcatcaa ataaaacgaa aggctcagtc     4380

gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca gtctgggcga     4440

aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt ttgcgtttct     4500

atcgatcccg cgaaattaat acgactcact ataggcccct ctagaaataa ttttgtttaa     4560

ctttaagctt taagaaggag atatagatca tggctgatga aattgatgca atggctttat     4620

atcgagcctg gcaacaactg gataatggat catgtgcgca aattagacgt gtttcagaac     4680

ctgatgaatt acgcgatatc cctgcgtttt ataggctggt gcaacctttt ggttgggaaa     4740

acccacgtca ccagcaggct cttttgcgca tggtgttttg cctgagcgca ggaaagaatg     4800

tcatccgaca tcaggacaaa aaatcggagc aaacaacagg tatctcgttg ggaagagctt     4860

tagccaatag tggaagaatt aacgagcgcc gtatctttca attaattcgg gctgacagaa     4920

cagccgatat ggtccagtta cgtcgattac ttactcacgc cgaacccgta cttgactggc     4980

cattaatggc caggatgttg acctggtggg gaaagcgcga acgccagcaa cttctggaag     5040

attttgtatt gaccacaaac aaaaatgcgt aataataaga tcccaactcc ataagtggct     5100

gctgccaccg ctgagcatag cataacccct tggggcctct aaacgggtct tgaggggttt     5160

tttgctgaaa ggaggaacta tatcaagtcc cgaagtagct gtcagactgc tggcgaccgc     5220

cgcaactagt ggcgtcatgc gtgccgtatg gtctttcgcc tgtagacgcc ctacaagccg     5280

tactaaagtg gaaagacccg caaaaggtat cgcgattaag gcatcaaata aaacgaaagg     5340

ctcagtcgaa agactgggcc tttcgtttta tctgttgttt gtcggtgagt ccttccagtc     5400

tgggcgaaag cgcggtcgat caaattaagc agaaggccat cctgacggat ggcctttttg     5460

cgtttctatc gatcccgcga aattaatacg actcactata ggcccctcta gaaataattt     5520

tgtttaactt taagctttaa gaaggagata tagatcatgt ctaactttat caatattcat     5580

gttctgatct ctcacagccc ttcatgtctg aaccgcgacg atatgaacat gcagaaagac     5640

gctattttcg gcggcaaaag acgagtaaga atttcaagtc aaagccttaa acgtgcgatg     5700

cgtaaaagtg gttattacgc acaaaatatt ggtgaatcca gtctcagaac cattcatctt     5760

gcacaattac gtgatgttct tcggcaaaaa cttggtgaac gttttgacca aaaaatcatc     5820

gataagacat tagcgctgct ctccggtaaa tcagttgatg aagccgaaaa gatttctgcc     5880

gatgcggtta ctccctgggt tgtgggagaa atagcctggt tctgtgagca ggttgcaaaa     5940

gcagaggctg ataatctgga tgataaaaag ctgctcaaag ttcttaagga agatattgcc     6000

gccatacgtg tgaatttaca gcagggtgtt gatattgcgc ttagtggaag aatggcaacc     6060

agcggcatga tgactgagtt gggaaaagtt gatggtgcaa tgtccattgc gcatgcgatc     6120

actactcatc aggttgattc tgatattgac tggttcaccg ctgtagatga tttacaggaa     6180

caaggttctg cacatctggg aactcaggaa ttttcatcgg gtgtttttta tcgttatgcc     6240

aacattaacc tcgctcaact tcaggaaaat ttaggtggtg cctccaggga gcaggctctg     6300

gaaattgcaa cccatgttgt tcatatgctg gcaacagagg tccctggagc aaaacagcgt     6360

acttatgccg cttttaaccc tgcggatatg gtaatggtta atttctccga tatgccactt     6420

tctatggcaa atgcttttga aaaagcggtt aaagcgaaag atggcttttt gcaaccgtct     6480

atacaggcgt ttaatcaata ttgggatcgc gttgccaatg gatatggtct gaacggagct     6540

gctgcgcaat tcagcttatc tgatgtagac ccaattactg ctcaagttaa acaaatgcct     6600

actttagaac agttaaaatc ctgggttcgt aataatggcg aggcgtgata ataagatccc     6660

aactccataa gtggctgctg ccaccgctga gcatagcata accccttggg gcctctaaac     6720

gggtcttgag gggttttttg ctgaaaggag gaactatatc aagtcccgaa gtagctgtca     6780

gactgctggc gaccgccgca actagtggcg tcatgcgtgc cgtatggtct ttcgcctgta     6840

gacgccctac aagccgtact aaagtggaaa gacccgcaaa aggtatcgcg attaaggcat     6900

caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttgtttgtcg     6960

gtgagtcctt ccagtctggg cgaaagcgcg gtcgatcaaa ttaagcagaa ggccatcctg     7020

acggatggcc tttttgcgtt tctatcgatc ccgcgaaatt aatacgactc actataggcc     7080

cctctagagc tagcgagttc cccgcgccag cggggataaa ccgccagtga taagtggaat     7140

gccatgtggg ctgtcgagtt ccccgcgcca gcggggataa accggagctc gctgagcata     7200

gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact     7260

atatcaagtc ccgaagtagc tgtcagactg ctggcgaccg ccgcaactag tggcgtcatg     7320

cgtgccgtat ggtctttcgc ctgtagacgc cctacaagcc gtactaaagt ggaaagaccc     7380

gcaaaaggta tcgcgattaa ggcatcaaat aaaacgaaag gctcagtcga aagactgggc     7440

ctttcgtttt atctgttgtt tgtcggtgag tccttccagt ctgggcgaaa gcgcggtcga     7500

tcaaattaag cagaaggcca tcctgacgga tggccttttt gcgtttctat cgatcccgcg     7560

aaattaatac gactcactat aggcccctct agaaataatt ttgtttaact ttaagcttta     7620

agaaggagat atagatcatg tatctcagta aagtcatcat tgccagggcc tggagcaggg     7680

atctttacca acttcaccag ggattatggc atttatttcc aaacagaccg gatgctgctc     7740

gtgattttct ttttcatgtt gagaagcgaa acacaccaga aggctgtcat gttttattgc     7800

agtcagcgca aatgcctgtt tcaactgccg ttgcgacagt cattaaaact aaacaggttg     7860

aatttcaact tcaggttggt gttccactct attttcggct tcgggcaaat ccgatcaaaa     7920

ctattctcga caatcaaaag cgcctggaca gtaaagggaa tattaaacgc tgtcgggttc     7980

cgttaataaa agaagcagaa caaatcgcgt ggttgcaacg taaattgggc aatgcggcgc     8040

gcgttgaaga tgtgcatccc atatcggaac ggccacagta tttttctggt gatggtaaaa     8100

gtggaaagat ccaaacggtt tgctttgaag gtgtgctcac catcaacgac gcgccagcgt     8160

taatagatct tgtacagcaa ggtattgggc cagctaaatc gatgggatgt ggcttgctat     8220

ctttggctcc actgtgataa taagatccca actccataag tggctgctgc caccgctgag     8280

catagcataa ccccttgggg cctctaaacg ggtcttgagg ggttttttgc tgaaaggagg     8340

aactatatca agtcccgaag tagctgtcag actgctggcg accgccgcaa ctagtggcgt     8400

catgcgtgcc gtatggtctt tcgcctgtag acgccctaca agccgtacta aagtggaaag     8460

acccgcaaaa ggtatcgcga ttaaggcatc aaataaaacg aaaggctcag tcgaaagact     8520

gggcctttcg ttttatctgt tgtttgtcgg tgagtccttc cagtctgggc gaaagcgcgg     8580

tcgatcaaat taagcagaag gccatcctga cggatggcct ttttgcgttt ctatcgatcc     8640

cgcgaaatta atacgactca ctataggccc ctctagaaat aattttgttt aactttaagc     8700

tttaagaagg agatatagat catgaatttg cttattgata actggatccc tgtacgcccg     8760

cgaaacgggg ggaaagtcca aatcataaat ctgcaatcgc tatactgcag tagagatcag     8820

tggcgattaa gtttgccccg tgacgatatg gaactggccg ctttagcact gctggtttgc     8880

attgggcaaa ttatcgcccc ggcaaaagat gacgttgaat ttcgacatcg cataatgaat     8940

ccgctcactg aagatgagtt tcaacaactc atcgcgccgt ggatagatat gttctacctt     9000

aatcacgcag aacatccctt tatgcagacc aaaggtgtca aagcaaatga tgtgactcca     9060

atggaaaaac tgttggctgg ggtaagcggc gcgacgaatt gtgcatttgt caatcaaccg     9120

gggcagggtg aagcattatg tggtggatgc actgcgattg cgttattcaa ccaggcgaat     9180

caggcaccag gttttggtgg tggttttaaa agcggtttac gtggaggaac acctgtaaca     9240

acgttcgtac gtgggatcga tcttcgttca acggtgttac tcaatgtcct cacattacct     9300

cgtcttcaaa aacaatttcc taatgaatca catacggaaa accaacctac ctggattaaa     9360

cctatcaagt ccaatgagtc tatacctgct tcgtcaattg ggtttgtccg tggtctattc     9420

tggcaaccag cgcatattga attatgcgat cccattggga ttggtaaatg ttcttgctgt     9480

ggacaggaaa gcaatttgcg ttataccggt tttcttaagg aaaaatttac ctttacagtt     9540

aatgggctat ggccccatcc gcattcccct tgtctggtaa cagtcaagaa aggggaggtt     9600

gaggaaaaat ttcttgcttt caccacctcc gcaccatcat ggacacaaat cagccgagtt     9660

gtggtagata agattattca aaatgaaaat ggaaatcgcg tggcggcggt tgtgaatcaa     9720

ttcagaaata ttgcgccgca aagtcctctt gaattgatta tggggggata tcgtaataat     9780

caagcatcta ttcttgaacg gcgtcatgat gtgttgatgt ttaatcaggg gtggcaacaa     9840

tacggcaatg tgataaacga aatagtgact gttggtttgg gatataaaac agccttacgc     9900

aaggcgttat atacctttgc agaagggttt aaaaataaag acttcaaagg ggccggagtc     9960

tctgttcatg agactgcaga aaggcatttc tatcgacaga gtgaattatt aattcccgat    10020

gtactggcga atgttaattt ttcccaggct gatgaggtaa tagctgattt acgagacaaa    10080

cttcatcaat tgtgtgaaat gctatttaat caatctgtag ctccctatgc acatcatcct    10140

aaattaataa gcacattagc gcttgcccgc gccacgctat acaaacattt acgggagtta    10200

aaaccgcaag gagggccatc aaatggctga taataagatc ccaactccat aagtggctgc    10260

tgccaccgct gagcatagca taaccccttg gggcctctaa acgggtcttg aggggttttt    10320

tgctgaaagg aggaactata tcaagtcccg aagtagctgt cagactgctg gcgaccgccg    10380

caactagtgg cgtcatgcgt gccgtatggt ctttcgcctg tagacgccct acaagccgta    10440

ctaaagtgga aagacccgca aaaggtatcg cgatcgccct gcagggaact atatccgact    10500

agtagcccgc ctaatgagcg ggcttttttt taattcccct atttgtttat ttttctaaat    10560

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc gaaaaaggaa    10620

gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct    10680

tcctgttttt gctcacccag aaacgctcgt gaaagtaaaa gacgcagagg accaattggg    10740

ggcacgagtg ggatacatag aactggactt gaatagcggt aaaatccttg agagttttcg    10800

ccctgaagag cgttttccaa tgatgagcac tttcaaagtt ctgctatgtg gagcagtatt    10860

atcccgtgta gatgcggggc aagagcaact cggacgacga atacactatt cgcagaatga    10920

cttggttgaa tactccccag tgacagaaaa gcaccttacg gacggaatga cggtaagaga    10980

attatgtagt gccgccataa cgatgagtga taacactgcg gcgaacttac ttctgacaac    11040

catcggtgga ccgaaggaat taaccgcttt tttgcacaat atgggagacc atgtaactcg    11100

ccttgaccgt tgggaaccag aactgaatga agccatacca aacgacgagc gagacaccac    11160

aatgcctgcg gcaatggcaa caacattacg caaactatta actggcgaac tacttactct    11220

ggcttcacgg caacaattaa tagactggct tgaagcggat aaagttgcag gaccactact    11280

gcgttcggca cttcctgctg gctggtttat tgctgataaa tctggggcag gagagcgtgg    11340

ttcacggggt atcattgccg cacttggacc agatggtaag ccttcccgta tcgtagttat    11400

ctacacgacg ggtagtcagg caactatgga cgaacgaaat agacagattg ctgaaatagg    11460

ggcttcactg attaagcatt ggtaaaccga tacaattaaa ggctcctttt ggagcctttt    11520

tttttggacg gaccggtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc    11580

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat    11640

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat    11700

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct    11760

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt    11820

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg    11880

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta    11940

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg    12000

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg    12060

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc    12120

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg    12180

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat    12240

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc    12300

agcgagtcag tgagcgagga agcggaagag cgcctgatgc ggtattttct ccttacgcat    12360

ctgtgcggta tttcacaccg caatggtgca ctctcagtac aatctgctct gatgccgcat    12420

agttaagcca gtatacactc cgctatcgct acgtgactgg gtcatggctg cgccccgaca    12480

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag    12540

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa    12600

acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg tgaagcgatt cacagatgtc    12660

tgcctgttca tccgcgtcca gctcgttgag tttctccaga agcgttaatg tctggcttct    12720

gataaagcgg gccatgttaa gggcggtttt ttcctgtttg gtcactgatg cctccgtgta    12780

agggggattt ctgttcatgg ggtaatgata ccgatgaaac gagagaggat gctcacgata    12840

cgggttactg atgatgaaca tgcccggtta ctggaacgtt gtgagggtaa acaactggcg    12900

gtatggatgc ggcgggacca gagaaaaatc actcagggtc aatgccagcg cttcgttaat    12960

acagatgtag gtgtt                                                     12975


<210>  365
<211>  9499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polypromoter(EcoCO), 
       CRISPR(J3/L3)_Cse2_Cas7_Cas5_Cas8_Cas6

<400>  365
ggcaccatgc atcgatcccg cgaaatgcgg ccgcttaatt aaggcatcaa ataaaacgaa       60

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca      120

gtctgggcga aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt      180

ttgcgtttct atcgatcccg cgaaattaat acgactcact ataggcccct ctagagctag      240

cgagttcccc gcgccagcgg ggataaaccg ccagtgataa gtggaatgcc atgtgggctg      300

tcgagttccc cgcgccagcg gggataaacc gagtggcaga tatagcctgg tggttcaggc      360

ggcgagttcc ccgcgccagc ggggataaac cggagctcgc tgagcatagc ataacccctt      420

ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atcaagtccc      480

gaagtagctg tcagactgct ggcgaccgcc gcaactagtg gcgtcatgcg tgccgtatgg      540

tctttcgcct gtagacgccc tacaagccgt actaaagtgg aaagacccgc aaaaggtatc      600

gcgattaagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat      660

ctgttgtttg tcggtgagtc cttccagtct gggcgaaagc gcggtcgatc aaattaagca      720

gaaggccatc ctgacggatg gcctttttgc gtttctatcg atcccgcgaa attaatacga      780

ctcactatag gcccctctag aaataatttt gtttaacttt aagctttaag aaggagatat      840

agatcatggc agatgaaatt gatgcaatgg cactgtatcg tgcatggcag cagctggata      900

atggtagctg tgcacagatt cgtcgtgtta gcgaaccgga tgaactgcgt gatattccgg      960

cattttatcg tctggttcag ccgtttggtt gggaaaatcc gcgtcatcag caggcactgc     1020

tgcgtatggt tttttgtctg agcgcaggta aaaatgttat tcgtcatcag gataaaaaaa     1080

gcgaacagac caccggtatt agcctgggtc gtgcactggc aaatagcggt cgtattaatg     1140

aacgtcgtat ttttcagctg attcgtgcag atcgtaccgc agatatggtt cagctgcgtc     1200

gtctgctgac ccatgcagaa ccggttctgg attggccgct gatggcacgt atgctgacct     1260

ggtggggtaa acgtgaacgt cagcagctgc tggaagattt tgttctgacc accaataaaa     1320

atgcctaata agcagaatgt tatcaatgcc atgcaggaat tctagcataa ccccttgggg     1380

cctctaaacg ggtcttgagg ggttttttgg ttttagccag ctggttgaag aactgctgaa     1440

aattatttgt gcatttcagc tggataccgg tctggaatat gcaaatagct acaattttgc     1500

caaaaaagat aatacgactc actataggcc cctgtagaaa taattttgtt taactttaat     1560

aaggagatat accatgagca actttattaa tattcatgtg ctgattagcc atagcccgag     1620

ctgcctgaat cgtgatgata tgaatatgca gaaagatgcc atttttggcg gtaaacgtcg     1680

tgttcgtatt agcagccaga gcctgaaacg tgcaatgcgt aaaagcggtt attatgcaca     1740

gaatattggt gaaagcagcc tgcgtaccat tcatctggca cagctgcgtg atgttctgcg     1800

tcagaaactg ggtgaacgtt ttgatcagaa aattattgat aaaaccctgg cactgctgag     1860

tggcaaaagc gttgatgaag cagaaaaaat tagcgcagat gcagttaccc cgtgggttgt     1920

tggtgaaatt gcctggtttt gcgaacaggt tgccaaagcc gaagcagata atctggatga     1980

taaaaaactg ctgaaagttc tgaaagaaga tattgccgcc attcgtgtta atctgcagca     2040

gggtgttgat attgcactga gcggtcgtat ggcaaccagc ggtatgatga ccgaactggg     2100

taaagttgat ggtgcaatga gcattgcaca tgcaattacc acccatcagg ttgatagcga     2160

tattgattgg tttaccgcag ttgatgatct gcaggaacag ggtagcgcac atctgggtac     2220

acaggaattt agcagcggtg tgttttatcg ttatgcaaat attaatctgg cccagctgca     2280

ggaaaatctg ggtggtgcaa gccgtgaaca ggcactggaa attgcaaccc atgttgttca     2340

tatgctggca accgaagttc cgggtgcaaa acagcgtacc tatgcagcct ttaatccggc     2400

agatatggtt atggttaatt ttagcgatat gccgctgtca atggcaaatg cctttgaaaa     2460

agcagtgaaa gccaaagatg gttttctgca gccgagcatt caggcattta atcagtattg     2520

ggatcgtgtt gcaaatggct atggtctgaa tggtgcagca gcacagttta gcctgagcga     2580

tgttgatccg attaccgcac aggttaaaca gatgccgacc ctggaacagc tgaaaagctg     2640

ggttcgtaat aatggtgaag cataataagg aatgtccgat ttgtctggaa ctgggcgcct     2700

agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgataa tagcccggaa     2760

catctgaaag atgaagtgtc tattattcag tcaatgggtt atcgcaatcg tgcaaaacgc     2820

ctgctgcaga gcgaaccgga aaatcctaat acgactcact ataggcccct caagaaataa     2880

ttttgtttaa ctttaagctt taagaaggag atatagatat gcgtagctat ctgattctgc     2940

gtctggcagg tccgatgcag gcatggggtc agccgacatt tgaaggtaca cgtccgacag     3000

gtcgttttcc gacacgtagt ggtctgctgg gtctgctggg tgcatgtctg ggtattcagc     3060

gtgatgatac cagcagtctg caggcactga gcgaaagcgt gcagtttgca gttcgttgtg     3120

atgaactgat tctggatgat cgtcgtgtta gcgtgaccgg tctgcgtgat tatcataccg     3180

ttctgggtgc acgtgaagat tatcgtggtc tgaaaagcca tgaaaccatt cagacctggc     3240

gtgaatatct gtgtgatgca agttttaccg ttgcactgtg gctgaccccg catgcaacaa     3300

tggttattag cgaactggaa aaagcagttc tgaaaccgcg ttataccccg tatctgggtc     3360

gtcgtagctg tccgctgacc catccgctgt ttctgggtac atgtcaggca agcgatccgc     3420

agaaagcact gctgaattat gaaccggttg gtggtgatat ttatagcgaa gaaagcgtta     3480

ccggtcatca tctgaaattt accgcacgtg atgaaccgat gattaccctg ccgcgtcagt     3540

ttgcaagccg tgaatggtat gttattaaag gtggtatgga tgttagccag taataagaac     3600

cggttagcac caagtgtgat cggtacccat cccaactcca taagtggctg ctgccaccgc     3660

tgagcatagc ataacccctt ggggcctcta aacgggtctt gaggggtttt ttgctgaaag     3720

gaggaactat atcaagtccc gaagtagctg tcagactgct ggcgaccgcc gcaactagtg     3780

gcgtcatgcg tgccgtatgg tctttcgcct gtagacgccc tacaagccgt actaaagtgg     3840

aaagacccgc aaaaggtatc gcgattaagg catcaaataa aacgaaaggc tcagtcgaaa     3900

gactgggcct ttcgttttat ctgttgtttg tcggtgagtc cttccagtct gggcgaaagc     3960

gcggtcgatc aaattaagca gaaggccatc ctgacggatg gcctttttgc gtttctatcg     4020

atcccgcgaa attaatacga ctcactatag gcccctctag aaataatttt gtttaacttt     4080

aagctttaag aaggagatat agatcatgaa tctgctgatt gataattgga ttccggttcg     4140

tccgcgtaat ggtggtaaag ttcagattat taatctgcag agcctgtatt gtagccgtga     4200

tcagtggcgt ctgagcctgc cgcgtgatga tatggaactg gcagcactgg cactgctggt     4260

ttgtattggt cagattattg caccggcaaa agatgatgtt gaatttcgcc atcgtattat     4320

gaatccgctg accgaagatg aatttcagca gctgattgcc ccgtggattg atatgtttta     4380

tctgaatcat gcagaacatc cgtttatgca gaccaaaggt gttaaagcaa atgatgttac     4440

cccgatggaa aaactgctgg ccggtgttag cggtgcaacc aattgtgcat ttgttaatca     4500

gccgggtcag ggtgaagcac tgtgtggtgg ttgtaccgca attgcactgt ttaatcaggc     4560

gaatcaggcc ccgggttttg gtggtggttt taaaagcggt ctgcgtggtg gtacaccggt     4620

taccaccttt gttcgtggta ttgatctgcg tagcaccgtt ctgctgaatg ttctgaccct     4680

gccgcgtctg cagaaacagt ttccgaatga aagccatacc gaaaatcagc cgacctggat     4740

taaaccgatt aaaagcaatg aaagcattcc ggcaagcagc attggttttg tgcgtggtct     4800

gttttggcag ccggcacata ttgaactgtg tgatccgatt ggtattggta aatgtagctg     4860

ttgtggtcag gaaagcaatc tgcgttatac cggctttctg aaagagaaat ttacctttac     4920

cgttaatggt ctgtggccgc atccgcatag cccgtgtctg gttaccgtga aaaaaggtga     4980

agttgaagaa aaatttctgg catttaccac cagcgcaccg agctggaccc agattagccg     5040

tgttgttgtt gataaaatta ttcagaatga aaatggcaat cgtgttgcag cagttgtgaa     5100

tcagtttcgt aatattgcgc cgcagagccc gctggaacta attatgggtg gttatcgtaa     5160

taatcaggca agcattctgg aacgccgtca tgatgttctg atgtttaatc agggttggca     5220

gcagtatggt aatgtgatta atgaaattgt gaccgttggt ctgggctata aaaccgcact     5280

gcgtaaagcg ctgtatacct ttgccgaagg ctttaaaaac aaagatttta aaggtgcagg     5340

cgttagcgtt catgaaaccg ccgaacgtca tttttatcgt cagagcgaac tgctgattcc     5400

ggatgtgctg gcaaatgtta attttagcca ggcagatgaa gttattgcag atctgcgcga     5460

taaactgcat cagctgtgtg aaatgctgtt taatcagagc gttgcaccgt atgcacatca     5520

tccgaaactg attagcaccc tggccctggc acgtgcaacc ctgtataaac atctgcgtga     5580

actgaaaccg cagggtggtc cgagcaatgg ttaataagga tctgtcagca ctgcgtgttg     5640

aaggatccca tcccaactcc ataagtggct gctgccaccg ctgagcatag cataacccct     5700

tggggcctct aaacgggtct tgaggggttt tttgctgaaa ggaggaacta tatcaagtcc     5760

cgaagtagct gtcagactgc tggcgaccgc cgcaactagt ggcgtcatgc gtgccgtatg     5820

gtctttcgcc tgtagacgcc ctacaagccg tactaaagtg gaaagacccg caaaaggtat     5880

cgcgattaag gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta     5940

tctgttgttt gtcggtgagt ccttccagtc tgggcgaaag cgcggtcgat caaattaagc     6000

agaaggccat cctgacggat ggcctttttg cgtttctatc gatcccgcga aattaatacg     6060

actcactata ggcccctcta gaaataattt tgtttaactt taagctttaa gaaggagata     6120

tagatcatgt atctgagcaa agttattatt gcacgtgcat ggagccgtga tctgtatcag     6180

ctgcatcagg gtctgtggca tctgtttccg aatcgtccgg atgcagcccg tgattttctg     6240

tttcatgttg aaaaacgtaa taccccggaa ggttgtcatg ttctgctgca gagcgcacag     6300

atgccggtta gcaccgcagt tgcaaccgtt attaaaacca aacaggtgga atttcagctg     6360

caggttggtg ttccgctgta ttttcgtctg cgtgccaatc cgattaaaac cattctggat     6420

aatcagaaac gtctggatag caaaggtaat attaaacgtt gccgcgtgcc gctgattaaa     6480

gaagccgaac agattgcatg gctgcagcgt aaactgggta atgcagcacg tgttgaagat     6540

gttcatccga ttagcgaacg tccgcagtat tttagcggtg atggtaaaag cggtaaaatt     6600

cagaccgttt gttttgaagg tgttctgacc attaatgatg caccggcact gattgatctg     6660

gttcagcagg gtattggtcc ggcaaaaagc atgggttgtg gtctgctgag tctggccccg     6720

ctgtaataag tccgagtcag tgtcctctgt gtaaccatgg gatcccaact ccataagtgg     6780

ctgctgccac cgctgagcat agcataaccc cttggggcct ctaaacgggt cttgaggggt     6840

tttttgctga aaggaggaac tatatcaagt cccgaagtag ctgtcagact gctggcgacc     6900

gccgcaacta gtggcgtcat gcgtgccgta tggtctttcg cctgtagacg ccctacaagc     6960

cgtactaaag tggaaagacc cgcaaaaggt atcgcgatcg ccctgcaggg aactatatcc     7020

gactagtagc ccgcctaatg agcgggcttt tttttaattc ccctatttgt ttatttttct     7080

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcgaaaaa     7140

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     7200

gccttcctgt ttttgctcac ccagaaacgc tcgtgaaagt aaaagacgca gaggaccaat     7260

tgggggcacg agtgggatac atagaactgg acttgaatag cggtaaaatc cttgagagtt     7320

ttcgccctga agagcgtttt ccaatgatga gcactttcaa agttctgcta tgtggagcag     7380

tattatcccg tgtagatgcg gggcaagagc aactcggacg acgaatacac tattcgcaga     7440

atgacttggt tgaatactcc ccagtgacag aaaagcacct tacggacgga atgacggtaa     7500

gagaattatg tagtgccgcc ataacgatga gtgataacac tgcggcgaac ttacttctga     7560

caaccatcgg tggaccgaag gaattaaccg cttttttgca caatatggga gaccatgtaa     7620

ctcgccttga ccgttgggaa ccagaactga atgaagccat accaaacgac gagcgagaca     7680

ccacaatgcc tgcggcaatg gcaacaacat tacgcaaact attaactggc gaactactta     7740

ctctggcttc acggcaacaa ttaatagact ggcttgaagc ggataaagtt gcaggaccac     7800

tactgcgttc ggcacttcct gctggctggt ttattgctga taaatctggg gcaggagagc     7860

gtggttcacg gggtatcatt gccgcacttg gaccagatgg taagccttcc cgtatcgtag     7920

ttatctacac gacgggtagt caggcaacta tggacgaacg aaatagacag attgctgaaa     7980

taggggcttc actgattaag cattggtaaa ccgatacaat taaaggctcc ttttggagcc     8040

tttttttttg gacggaccgg tagaaaagat caaaggatct tcttgagatc ctttttttct     8100

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     8160

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     8220

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     8280

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     8340

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     8400

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     8460

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     8520

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     8580

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     8640

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     8700

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     8760

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     8820

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     8880

gcatctgtgc ggtatttcac accgcaatgg tgcactctca gtacaatctg ctctgatgcc     8940

gcatagttaa gccagtatac actccgctat cgctacgtga ctgggtcatg gctgcgcccc     9000

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     9060

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     9120

cgaaacgcgc gaggcagctg cggtaaagct catcagcgtg gtcgtgaagc gattcacaga     9180

tgtctgcctg ttcatccgcg tccagctcgt tgagtttctc cagaagcgtt aatgtctggc     9240

ttctgataaa gcgggccatg ttaagggcgg ttttttcctg tttggtcact gatgcctccg     9300

tgtaaggggg atttctgttc atggggtaat gataccgatg aaacgagaga ggatgctcac     9360

gatacgggtt actgatgatg aacatgcccg gttactggaa cgttgtgagg gtaaacaact     9420

ggcggtatgg atgcggcggg accagagaaa aatcactcag ggtcaatgcc agcgcttcgt     9480

taatacagat gtaggtgtt                                                  9499


<210>  366
<211>  10210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polypromoter(EcoCO), 
       CRISPR(J3/L3)_Cse2_Cas7_Cas5_Cas8_FokI-30aa-Cas6

<400>  366
ggcaccatgc atcgatcccg cgaaatgcgg ccgcttaatt aaggcatcaa ataaaacgaa       60

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca      120

gtctgggcga aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt      180

ttgcgtttct atcgatcccg cgaaattaat acgactcact ataggcccct ctagagctag      240

cgagttcccc gcgccagcgg ggataaaccg ccagtgataa gtggaatgcc atgtgggctg      300

tcgagttccc cgcgccagcg gggataaacc gagtggcaga tatagcctgg tggttcaggc      360

ggcgagttcc ccgcgccagc ggggataaac cggagctcgc tgagcatagc ataacccctt      420

ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atcaagtccc      480

gaagtagctg tcagactgct ggcgaccgcc gcaactagtg gcgtcatgcg tgccgtatgg      540

tctttcgcct gtagacgccc tacaagccgt actaaagtgg aaagacccgc aaaaggtatc      600

gcgattaagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat      660

ctgttgtttg tcggtgagtc cttccagtct gggcgaaagc gcggtcgatc aaattaagca      720

gaaggccatc ctgacggatg gcctttttgc gtttctatcg atcccgcgaa attaatacga      780

ctcactatag gcccctctag aaataatttt gtttaacttt aagctttaag aaggagatat      840

agatcatggc agatgaaatt gatgcaatgg cactgtatcg tgcatggcag cagctggata      900

atggtagctg tgcacagatt cgtcgtgtta gcgaaccgga tgaactgcgt gatattccgg      960

cattttatcg tctggttcag ccgtttggtt gggaaaatcc gcgtcatcag caggcactgc     1020

tgcgtatggt tttttgtctg agcgcaggta aaaatgttat tcgtcatcag gataaaaaaa     1080

gcgaacagac caccggtatt agcctgggtc gtgcactggc aaatagcggt cgtattaatg     1140

aacgtcgtat ttttcagctg attcgtgcag atcgtaccgc agatatggtt cagctgcgtc     1200

gtctgctgac ccatgcagaa ccggttctgg attggccgct gatggcacgt atgctgacct     1260

ggtggggtaa acgtgaacgt cagcagctgc tggaagattt tgttctgacc accaataaaa     1320

atgcctaata agcagaatgt tatcaatgcc atgcaggaat tctagcataa ccccttgggg     1380

cctctaaacg ggtcttgagg ggttttttgg ttttagccag ctggttgaag aactgctgaa     1440

aattatttgt gcatttcagc tggataccgg tctggaatat gcaaatagct acaattttgc     1500

caaaaaagat aatacgactc actataggcc cctgtagaaa taattttgtt taactttaat     1560

aaggagatat accatgagca actttattaa tattcatgtg ctgattagcc atagcccgag     1620

ctgcctgaat cgtgatgata tgaatatgca gaaagatgcc atttttggcg gtaaacgtcg     1680

tgttcgtatt agcagccaga gcctgaaacg tgcaatgcgt aaaagcggtt attatgcaca     1740

gaatattggt gaaagcagcc tgcgtaccat tcatctggca cagctgcgtg atgttctgcg     1800

tcagaaactg ggtgaacgtt ttgatcagaa aattattgat aaaaccctgg cactgctgag     1860

tggcaaaagc gttgatgaag cagaaaaaat tagcgcagat gcagttaccc cgtgggttgt     1920

tggtgaaatt gcctggtttt gcgaacaggt tgccaaagcc gaagcagata atctggatga     1980

taaaaaactg ctgaaagttc tgaaagaaga tattgccgcc attcgtgtta atctgcagca     2040

gggtgttgat attgcactga gcggtcgtat ggcaaccagc ggtatgatga ccgaactggg     2100

taaagttgat ggtgcaatga gcattgcaca tgcaattacc acccatcagg ttgatagcga     2160

tattgattgg tttaccgcag ttgatgatct gcaggaacag ggtagcgcac atctgggtac     2220

acaggaattt agcagcggtg tgttttatcg ttatgcaaat attaatctgg cccagctgca     2280

ggaaaatctg ggtggtgcaa gccgtgaaca ggcactggaa attgcaaccc atgttgttca     2340

tatgctggca accgaagttc cgggtgcaaa acagcgtacc tatgcagcct ttaatccggc     2400

agatatggtt atggttaatt ttagcgatat gccgctgtca atggcaaatg cctttgaaaa     2460

agcagtgaaa gccaaagatg gttttctgca gccgagcatt caggcattta atcagtattg     2520

ggatcgtgtt gcaaatggct atggtctgaa tggtgcagca gcacagttta gcctgagcga     2580

tgttgatccg attaccgcac aggttaaaca gatgccgacc ctggaacagc tgaaaagctg     2640

ggttcgtaat aatggtgaag cataataagg aatgtccgat ttgtctggaa ctgggcgcct     2700

agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgataa tagcccggaa     2760

catctgaaag atgaagtgtc tattattcag tcaatgggtt atcgcaatcg tgcaaaacgc     2820

ctgctgcaga gcgaaccgga aaatcctaat acgactcact ataggcccct caagaaataa     2880

ttttgtttaa ctttaagctt taagaaggag atatagatat gcgtagctat ctgattctgc     2940

gtctggcagg tccgatgcag gcatggggtc agccgacatt tgaaggtaca cgtccgacag     3000

gtcgttttcc gacacgtagt ggtctgctgg gtctgctggg tgcatgtctg ggtattcagc     3060

gtgatgatac cagcagtctg caggcactga gcgaaagcgt gcagtttgca gttcgttgtg     3120

atgaactgat tctggatgat cgtcgtgtta gcgtgaccgg tctgcgtgat tatcataccg     3180

ttctgggtgc acgtgaagat tatcgtggtc tgaaaagcca tgaaaccatt cagacctggc     3240

gtgaatatct gtgtgatgca agttttaccg ttgcactgtg gctgaccccg catgcaacaa     3300

tggttattag cgaactggaa aaagcagttc tgaaaccgcg ttataccccg tatctgggtc     3360

gtcgtagctg tccgctgacc catccgctgt ttctgggtac atgtcaggca agcgatccgc     3420

agaaagcact gctgaattat gaaccggttg gtggtgatat ttatagcgaa gaaagcgtta     3480

ccggtcatca tctgaaattt accgcacgtg atgaaccgat gattaccctg ccgcgtcagt     3540

ttgcaagccg tgaatggtat gttattaaag gtggtatgga tgttagccag taataagaac     3600

cggttagcac caagtgtgat cggtacccat cccaactcca taagtggctg ctgccaccgc     3660

tgagcatagc ataacccctt ggggcctcta aacgggtctt gaggggtttt ttgctgaaag     3720

gaggaactat atcaagtccc gaagtagctg tcagactgct ggcgaccgcc gcaactagtg     3780

gcgtcatgcg tgccgtatgg tctttcgcct gtagacgccc tacaagccgt actaaagtgg     3840

aaagacccgc aaaaggtatc gcgattaagg catcaaataa aacgaaaggc tcagtcgaaa     3900

gactgggcct ttcgttttat ctgttgtttg tcggtgagtc cttccagtct gggcgaaagc     3960

gcggtcgatc aaattaagca gaaggccatc ctgacggatg gcctttttgc gtttctatcg     4020

atcccgcgaa attaatacga ctcactatag gcccctctag aaataatttt gtttaacttt     4080

aagctttaag aaggagatat agatcatgaa tctgctgatt gataattgga ttccggttcg     4140

tccgcgtaat ggtggtaaag ttcagattat taatctgcag agcctgtatt gtagccgtga     4200

tcagtggcgt ctgagcctgc cgcgtgatga tatggaactg gcagcactgg cactgctggt     4260

ttgtattggt cagattattg caccggcaaa agatgatgtt gaatttcgcc atcgtattat     4320

gaatccgctg accgaagatg aatttcagca gctgattgcc ccgtggattg atatgtttta     4380

tctgaatcat gcagaacatc cgtttatgca gaccaaaggt gttaaagcaa atgatgttac     4440

cccgatggaa aaactgctgg ccggtgttag cggtgcaacc aattgtgcat ttgttaatca     4500

gccgggtcag ggtgaagcac tgtgtggtgg ttgtaccgca attgcactgt ttaatcaggc     4560

gaatcaggcc ccgggttttg gtggtggttt taaaagcggt ctgcgtggtg gtacaccggt     4620

taccaccttt gttcgtggta ttgatctgcg tagcaccgtt ctgctgaatg ttctgaccct     4680

gccgcgtctg cagaaacagt ttccgaatga aagccatacc gaaaatcagc cgacctggat     4740

taaaccgatt aaaagcaatg aaagcattcc ggcaagcagc attggttttg tgcgtggtct     4800

gttttggcag ccggcacata ttgaactgtg tgatccgatt ggtattggta aatgtagctg     4860

ttgtggtcag gaaagcaatc tgcgttatac cggctttctg aaagagaaat ttacctttac     4920

cgttaatggt ctgtggccgc atccgcatag cccgtgtctg gttaccgtga aaaaaggtga     4980

agttgaagaa aaatttctgg catttaccac cagcgcaccg agctggaccc agattagccg     5040

tgttgttgtt gataaaatta ttcagaatga aaatggcaat cgtgttgcag cagttgtgaa     5100

tcagtttcgt aatattgcgc cgcagagccc gctggaacta attatgggtg gttatcgtaa     5160

taatcaggca agcattctgg aacgccgtca tgatgttctg atgtttaatc agggttggca     5220

gcagtatggt aatgtgatta atgaaattgt gaccgttggt ctgggctata aaaccgcact     5280

gcgtaaagcg ctgtatacct ttgccgaagg ctttaaaaac aaagatttta aaggtgcagg     5340

cgttagcgtt catgaaaccg ccgaacgtca tttttatcgt cagagcgaac tgctgattcc     5400

ggatgtgctg gcaaatgtta attttagcca ggcagatgaa gttattgcag atctgcgcga     5460

taaactgcat cagctgtgtg aaatgctgtt taatcagagc gttgcaccgt atgcacatca     5520

tccgaaactg attagcaccc tggccctggc acgtgcaacc ctgtataaac atctgcgtga     5580

actgaaaccg cagggtggtc cgagcaatgg ttaataagga tctgtcagca ctgcgtgttg     5640

aaggatccca tcccaactcc ataagtggct gctgccaccg ctgagcatag cataacccct     5700

tggggcctct aaacgggtct tgaggggttt tttgctgaaa ggaggaacta tatcaagtcc     5760

cgaagtagct gtcagactgc tggcgaccgc cgcaactagt ggcgtcatgc gtgccgtatg     5820

gtctttcgcc tgtagacgcc ctacaagccg tactaaagtg gaaagacccg caaaaggtat     5880

cgcgattaag gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta     5940

tctgttgttt gtcggtgagt ccttccagtc tgggcgaaag cgcggtcgat caaattaagc     6000

agaaggccat cctgacggat ggcctttttg cgtttctatc gatcccgcga aattaatacg     6060

actcactata ggcccctcta gaaataattt tgtttaactt taagctttaa gaaggagata     6120

tagatcatgc cgaaaaaaaa gcgcaaagtg ggtggctctc aactggttaa aagcgaactg     6180

gaagagaaaa aaagtgaact gcgccacaaa ctgaaatatg tgccgcatga atatatcgag     6240

ctgattgaaa ttgcacgtaa tccgacccag gatcgtattc tggaaatgaa agtgatggaa     6300

ttttttatga aagtgtacgg ctatcgcggt gaacatctgg gtggtagccg taaaccggat     6360

ggtgcaattt ataccgttgg tagcccgatt gattatggtg ttattgttga taccaaagcc     6420

tatagcggtg gttataatct gccgattggt caggcagatg aaatgcagcg ttatgtggaa     6480

gaaaatcaga cccgtaacaa acatattaat ccgaatgaat ggtggaaagt ttatccgagc     6540

agcgttaccg agtttaaatt cctgtttgtt agcggtcact tcaaaggcaa ctataaagca     6600

cagctgaccc gtctgaatca tattaccaat tgtaatggtg cagttctgag cgttgaagaa     6660

ctgctgattg gtggtgaaat gattaaagca ggcaccctga ccctggaaga agttcgtcgc     6720

aaatttaaca atggcgaaat caacttttca ggcagcgaaa cgccgggtac aagtgagtca     6780

gcaactccag agagcggcgg cagtggtagt agtgggggat ctgggtcatc tggtgggatg     6840

tatctgagca aagttattat tgcacgtgca tggagccgtg atctgtatca gctgcatcag     6900

ggtctgtggc atctgtttcc gaatcgtccg gatgcagccc gtgattttct gtttcatgtt     6960

gaaaaacgta ataccccgga aggttgtcat gttctgctgc agagcgcaca gatgccggtt     7020

agcaccgcag ttgcaaccgt tattaaaacc aaacaggtgg aatttcagct gcaggttggt     7080

gttccgctgt attttcgtct gcgtgccaat ccgattaaaa ccattctgga taatcagaaa     7140

cgtctggata gcaaaggtaa tattaaacgt tgccgcgtgc cgctgattaa agaagccgaa     7200

cagattgcat ggctgcagcg taaactgggt aatgcagcac gtgttgaaga tgttcatccg     7260

attagcgaac gtccgcagta ttttagcggt gatggtaaaa gcggtaaaat tcagaccgtt     7320

tgttttgaag gtgttctgac cattaatgat gcaccggcac tgattgatct ggttcagcag     7380

ggtattggtc cggcaaaaag catgggttgt ggtctgctga gtctggcccc gctgtaataa     7440

gtccgagtca gtgtcctctg tgtaaccatg ggatcccaac tccataagtg gctgctgcca     7500

ccgctgagca tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgctg     7560

aaaggaggaa ctatatcaag tcccgaagta gctgtcagac tgctggcgac cgccgcaact     7620

agtggcgtca tgcgtgccgt atggtctttc gcctgtagac gccctacaag ccgtactaaa     7680

gtggaaagac ccgcaaaagg tatcgcgatc gccctgcagg gaactatatc cgactagtag     7740

cccgcctaat gagcgggctt ttttttaatt cccctatttg tttatttttc taaatacatt     7800

caaatatgta tccgctcatg agacaataac cctgataaat gcttcgaaaa aggaagagta     7860

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     7920

tttttgctca cccagaaacg ctcgtgaaag taaaagacgc agaggaccaa ttgggggcac     7980

gagtgggata catagaactg gacttgaata gcggtaaaat ccttgagagt tttcgccctg     8040

aagagcgttt tccaatgatg agcactttca aagttctgct atgtggagca gtattatccc     8100

gtgtagatgc ggggcaagag caactcggac gacgaataca ctattcgcag aatgacttgg     8160

ttgaatactc cccagtgaca gaaaagcacc ttacggacgg aatgacggta agagaattat     8220

gtagtgccgc cataacgatg agtgataaca ctgcggcgaa cttacttctg acaaccatcg     8280

gtggaccgaa ggaattaacc gcttttttgc acaatatggg agaccatgta actcgccttg     8340

accgttggga accagaactg aatgaagcca taccaaacga cgagcgagac accacaatgc     8400

ctgcggcaat ggcaacaaca ttacgcaaac tattaactgg cgaactactt actctggctt     8460

cacggcaaca attaatagac tggcttgaag cggataaagt tgcaggacca ctactgcgtt     8520

cggcacttcc tgctggctgg tttattgctg ataaatctgg ggcaggagag cgtggttcac     8580

ggggtatcat tgccgcactt ggaccagatg gtaagccttc ccgtatcgta gttatctaca     8640

cgacgggtag tcaggcaact atggacgaac gaaatagaca gattgctgaa ataggggctt     8700

cactgattaa gcattggtaa accgatacaa ttaaaggctc cttttggagc cttttttttt     8760

ggacggaccg gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat     8820

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga     8880

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt     8940

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata     9000

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac     9060

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg     9120

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg     9180

tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag     9240

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct     9300

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc     9360

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt     9420

ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg     9480

tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga     9540

gtcagtgagc gaggaagcgg aagagcgcct gatgcggtat tttctcctta cgcatctgtg     9600

cggtatttca caccgcaatg gtgcactctc agtacaatct gctctgatgc cgcatagtta     9660

agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc cgacacccgc     9720

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     9780

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     9840

cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag atgtctgcct     9900

gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg cttctgataa     9960

agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc gtgtaagggg    10020

gatttctgtt catggggtaa tgataccgat gaaacgagag aggatgctca cgatacgggt    10080

tactgatgat gaacatgccc ggttactgga acgttgtgag ggtaaacaac tggcggtatg    10140

gatgcggcgg gaccagagaa aaatcactca gggtcaatgc cagcgcttcg ttaatacaga    10200

tgtaggtgtt                                                           10210


<210>  367
<211>  10201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polypromoter(EcoCO), 
       CRISPR(J3/L3)_Cse2_Cas7_Cas5_Cas6_FokI-30aa-Cas8

<400>  367
ggcaccatgc atcgatcccg cgaaatgcgg ccgcttaatt aaggcatcaa ataaaacgaa       60

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg agtccttcca      120

gtctgggcga aagcgcggtc gatcaaatta agcagaaggc catcctgacg gatggccttt      180

ttgcgtttct atcgatcccg cgaaattaat acgactcact ataggcccct ctagagctag      240

cgagttcccc gcgccagcgg ggataaaccg ccagtgataa gtggaatgcc atgtgggctg      300

tcgagttccc cgcgccagcg gggataaacc gagtggcaga tatagcctgg tggttcaggc      360

ggcgagttcc ccgcgccagc ggggataaac cggagctcgc tgagcatagc ataacccctt      420

ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atcaagtccc      480

gaagtagctg tcagactgct ggcgaccgcc gcaactagtg gcgtcatgcg tgccgtatgg      540

tctttcgcct gtagacgccc tacaagccgt actaaagtgg aaagacccgc aaaaggtatc      600

gcgattaagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat      660

ctgttgtttg tcggtgagtc cttccagtct gggcgaaagc gcggtcgatc aaattaagca      720

gaaggccatc ctgacggatg gcctttttgc gtttctatcg atcccgcgaa attaatacga      780

ctcactatag gcccctctag aaataatttt gtttaacttt aagctttaag aaggagatat      840

agatcatggc agatgaaatt gatgcaatgg cactgtatcg tgcatggcag cagctggata      900

atggtagctg tgcacagatt cgtcgtgtta gcgaaccgga tgaactgcgt gatattccgg      960

cattttatcg tctggttcag ccgtttggtt gggaaaatcc gcgtcatcag caggcactgc     1020

tgcgtatggt tttttgtctg agcgcaggta aaaatgttat tcgtcatcag gataaaaaaa     1080

gcgaacagac caccggtatt agcctgggtc gtgcactggc aaatagcggt cgtattaatg     1140

aacgtcgtat ttttcagctg attcgtgcag atcgtaccgc agatatggtt cagctgcgtc     1200

gtctgctgac ccatgcagaa ccggttctgg attggccgct gatggcacgt atgctgacct     1260

ggtggggtaa acgtgaacgt cagcagctgc tggaagattt tgttctgacc accaataaaa     1320

atgcctaata agcagaatgt tatcaatgcc atgcaggaat tctagcataa ccccttgggg     1380

cctctaaacg ggtcttgagg ggttttttgg ttttagccag ctggttgaag aactgctgaa     1440

aattatttgt gcatttcagc tggataccgg tctggaatat gcaaatagct acaattttgc     1500

caaaaaagat aatacgactc actataggcc cctgtagaaa taattttgtt taactttaat     1560

aaggagatat accatgagca actttattaa tattcatgtg ctgattagcc atagcccgag     1620

ctgcctgaat cgtgatgata tgaatatgca gaaagatgcc atttttggcg gtaaacgtcg     1680

tgttcgtatt agcagccaga gcctgaaacg tgcaatgcgt aaaagcggtt attatgcaca     1740

gaatattggt gaaagcagcc tgcgtaccat tcatctggca cagctgcgtg atgttctgcg     1800

tcagaaactg ggtgaacgtt ttgatcagaa aattattgat aaaaccctgg cactgctgag     1860

tggcaaaagc gttgatgaag cagaaaaaat tagcgcagat gcagttaccc cgtgggttgt     1920

tggtgaaatt gcctggtttt gcgaacaggt tgccaaagcc gaagcagata atctggatga     1980

taaaaaactg ctgaaagttc tgaaagaaga tattgccgcc attcgtgtta atctgcagca     2040

gggtgttgat attgcactga gcggtcgtat ggcaaccagc ggtatgatga ccgaactggg     2100

taaagttgat ggtgcaatga gcattgcaca tgcaattacc acccatcagg ttgatagcga     2160

tattgattgg tttaccgcag ttgatgatct gcaggaacag ggtagcgcac atctgggtac     2220

acaggaattt agcagcggtg tgttttatcg ttatgcaaat attaatctgg cccagctgca     2280

ggaaaatctg ggtggtgcaa gccgtgaaca ggcactggaa attgcaaccc atgttgttca     2340

tatgctggca accgaagttc cgggtgcaaa acagcgtacc tatgcagcct ttaatccggc     2400

agatatggtt atggttaatt ttagcgatat gccgctgtca atggcaaatg cctttgaaaa     2460

agcagtgaaa gccaaagatg gttttctgca gccgagcatt caggcattta atcagtattg     2520

ggatcgtgtt gcaaatggct atggtctgaa tggtgcagca gcacagttta gcctgagcga     2580

tgttgatccg attaccgcac aggttaaaca gatgccgacc ctggaacagc tgaaaagctg     2640

ggttcgtaat aatggtgaag cataataagg aatgtccgat ttgtctggaa ctgggcgcct     2700

agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgataa tagcccggaa     2760

catctgaaag atgaagtgtc tattattcag tcaatgggtt atcgcaatcg tgcaaaacgc     2820

ctgctgcaga gcgaaccgga aaatcctaat acgactcact ataggcccct caagaaataa     2880

ttttgtttaa ctttaagctt taagaaggag atatagatat gcgtagctat ctgattctgc     2940

gtctggcagg tccgatgcag gcatggggtc agccgacatt tgaaggtaca cgtccgacag     3000

gtcgttttcc gacacgtagt ggtctgctgg gtctgctggg tgcatgtctg ggtattcagc     3060

gtgatgatac cagcagtctg caggcactga gcgaaagcgt gcagtttgca gttcgttgtg     3120

atgaactgat tctggatgat cgtcgtgtta gcgtgaccgg tctgcgtgat tatcataccg     3180

ttctgggtgc acgtgaagat tatcgtggtc tgaaaagcca tgaaaccatt cagacctggc     3240

gtgaatatct gtgtgatgca agttttaccg ttgcactgtg gctgaccccg catgcaacaa     3300

tggttattag cgaactggaa aaagcagttc tgaaaccgcg ttataccccg tatctgggtc     3360

gtcgtagctg tccgctgacc catccgctgt ttctgggtac atgtcaggca agcgatccgc     3420

agaaagcact gctgaattat gaaccggttg gtggtgatat ttatagcgaa gaaagcgtta     3480

ccggtcatca tctgaaattt accgcacgtg atgaaccgat gattaccctg ccgcgtcagt     3540

ttgcaagccg tgaatggtat gttattaaag gtggtatgga tgttagccag taataagaac     3600

cggttagcac caagtgtgat cggtacccat cccaactcca taagtggctg ctgccaccgc     3660

tgagcatagc ataacccctt ggggcctcta aacgggtctt gaggggtttt ttgctgaaag     3720

gaggaactat atcaagtccc gaagtagctg tcagactgct ggcgaccgcc gcaactagtg     3780

gcgtcatgcg tgccgtatgg tctttcgcct gtagacgccc tacaagccgt actaaagtgg     3840

aaagacccgc aaaaggtatc gcgattaagg catcaaataa aacgaaaggc tcagtcgaaa     3900

gactgggcct ttcgttttat ctgttgtttg tcggtgagtc cttccagtct gggcgaaagc     3960

gcggtcgatc aaattaagca gaaggccatc ctgacggatg gcctttttgc gtttctatcg     4020

atcccgcgaa attaatacga ctcactatag gcccctctag aaataatttt gtttaacttt     4080

aagctttaag aaggagatat agatcatgta tctgagcaaa gttattattg cacgtgcatg     4140

gagccgtgat ctgtatcagc tgcatcaggg tctgtggcat ctgtttccga atcgtccgga     4200

tgcagcccgt gattttctgt ttcatgttga aaaacgtaat accccggaag gttgtcatgt     4260

tctgctgcag agcgcacaga tgccggttag caccgcagtt gcaaccgtta ttaaaaccaa     4320

acaggtggaa tttcagctgc aggttggtgt tccgctgtat tttcgtctgc gtgccaatcc     4380

gattaaaacc attctggata atcagaaacg tctggatagc aaaggtaata ttaaacgttg     4440

ccgcgtgccg ctgattaaag aagccgaaca gattgcatgg ctgcagcgta aactgggtaa     4500

tgcagcacgt gttgaagatg ttcatccgat tagcgaacgt ccgcagtatt ttagcggtga     4560

tggtaaaagc ggtaaaattc agaccgtttg ttttgaaggt gttctgacca ttaatgatgc     4620

accggcactg attgatctgg ttcagcaggg tattggtccg gcaaaaagca tgggttgtgg     4680

tctgctgagt ctggccccgc tgtaataagt ccgagtcagt gtcctctgtg taaccatggg     4740

atcccaactc cataagtggc tgctgccacc gctgagcata gcataacccc ttggggcctc     4800

taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatcaagtc ccgaagtagc     4860

tgtcagactg ctggcgaccg ccgcaactag tggcgtcatg cgtgccgtat ggtctttcgc     4920

ctgtagacgc cctacaagcc gtactaaagt ggaaagaccc gcaaaaggta tcgcgattaa     4980

ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt     5040

tgtcggtgag tccttccagt ctgggcgaaa gcgcggtcga tcaaattaag cagaaggcca     5100

tcctgacgga tggccttttt gcgtttctat cgatcccgcg aaattaatac gactcactat     5160

aggcccctct agaaataatt ttgtttaact ttaagcttta agaaggagat atagatcatg     5220

ccgaaaaaaa agcgcaaagt gcaactggtt aaaagcgaac tggaagagaa aaaaagtgaa     5280

ctgcgccaca aactgaaata tgtgccgcat gaatatatcg agctgattga aattgcacgt     5340

aatccgaccc aggatcgtat tctggaaatg aaagtgatgg aattttttat gaaagtgtac     5400

ggctatcgcg gtgaacatct gggtggtagc cgtaaaccgg atggtgcaat ttataccgtt     5460

ggtagcccga ttgattatgg tgttattgtt gataccaaag cctatagcgg tggttataat     5520

ctgccgattg gtcaggcaga tgaaatgcag cgttatgtgg aagaaaatca gacccgtaac     5580

aaacatatta atccgaatga atggtggaaa gtttatccga gcagcgttac cgagtttaaa     5640

ttcctgtttg ttagcggtca cttcaaaggc aactataaag cacagctgac ccgtctgaat     5700

catattacca attgtaatgg tgcagttctg agcgttgaag aactgctgat tggtggtgaa     5760

atgattaaag caggcaccct gaccctggaa gaagttcgtc gcaaatttaa caatggcgaa     5820

atcaactttt caggcagcga aacgccgggt acaagtgagt cagcaactcc agagagcggc     5880

ggcagtggta gtagtggggg atctgggtca tctggtggga tgaatttgct tattgataac     5940

tggattcctg tacgcccgcg aaacgggggg aaagtccaaa tcataaatct gcaatcgcta     6000

tactgcagta gagatcagtg gcgattaagt ttgccccgtg acgatatgga actggccgct     6060

ttagcactgc tggtttgcat tgggcaaatt atcgccccgg caaaagatga cgttgaattt     6120

cgacatcgca taatgaatcc gctcactgaa gatgagtttc aacaactcat cgcgccgtgg     6180

atagatatgt tctaccttaa tcacgcagaa catcccttta tgcagaccaa aggtgtcaaa     6240

gcaaatgatg tgactccaat ggaaaaactg ttggctgggg taagcggcgc gacgaattgt     6300

gcatttgtca atcaaccggg gcagggtgaa gcattatgtg gtggatgcac tgcgattgcg     6360

ttattcaacc aggcgaatca ggcaccaggt tttggtggtg gttttaaaag cggtttacgt     6420

ggaggaacac ctgtaacaac gttcgtacgt gggatcgatc ttcgttcaac ggtgttactc     6480

aatgtcctca cattacctcg tcttcaaaaa caatttccta atgaatcaca tacggaaaac     6540

caacctacct ggattaaacc tatcaagtcc aatgagtcta tacctgcttc gtcaattggg     6600

tttgtccgtg gtctattctg gcaaccagcg catattgaat tatgcgatcc cattgggatt     6660

ggtaaatgtt cttgctgtgg acaggaaagc aatttgcgtt ataccggttt tcttaaggaa     6720

aaatttacct ttacagttaa tgggctatgg ccccatccgc attccccttg tctggtaaca     6780

gtcaagaaag gggaggttga ggaaaaattt cttgctttca ccacctccgc accatcatgg     6840

acacaaatca gccgagttgt ggtagataag attattcaaa atgaaaatgg aaatcgcgtg     6900

gcggcggttg tgaatcaatt cagaaatatt gcgccgcaaa gtcctcttga attgattatg     6960

gggggatatc gtaataatca agcatctatt cttgaacggc gtcatgatgt gttgatgttt     7020

aatcaggggt ggcaacaata cggcaatgtg ataaacgaaa tagtgactgt tggtttggga     7080

tataaaacag ccttacgcaa ggcgttatat acctttgcag aagggtttaa aaataaagac     7140

ttcaaagggg ccggagtctc tgttcatgag actgcagaaa ggcatttcta tcgacagagt     7200

gaattattaa ttcccgatgt actggcgaat gttaattttt cccaggctga tgaggtaata     7260

gctgatttac gagacaaact tcatcaattg tgtgaaatgc tatttaatca atctgtagct     7320

ccctatgcac atcatcctaa attaataagc acattagcgc ttgcccgcgc cacgctatac     7380

aaacatttac gggagttaaa accgcaagga gggccatcaa atggctaata aggatctgtc     7440

agcactgcgt gttgaaggat ccgatcccaa ctccataagt ggctgctgcc accgctgagc     7500

atagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga     7560

actatatcaa gtcccgaagt agctgtcaga ctgctggcga ccgccgcaac tagtggcgtc     7620

atgcgtgccg tatggtcttt cgcctgtaga cgccctacaa gccgtactaa agtggaaaga     7680

cccgcaaaag gtatcgcgat cgccctgcag ggaactatat ccgactagta gcccgcctaa     7740

tgagcgggct tttttttaat tcccctattt gtttattttt ctaaatacat tcaaatatgt     7800

atccgctcat gagacaataa ccctgataaa tgcttcgaaa aaggaagagt atgagtattc     7860

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     7920

acccagaaac gctcgtgaaa gtaaaagacg cagaggacca attgggggca cgagtgggat     7980

acatagaact ggacttgaat agcggtaaaa tccttgagag ttttcgccct gaagagcgtt     8040

ttccaatgat gagcactttc aaagttctgc tatgtggagc agtattatcc cgtgtagatg     8100

cggggcaaga gcaactcgga cgacgaatac actattcgca gaatgacttg gttgaatact     8160

ccccagtgac agaaaagcac cttacggacg gaatgacggt aagagaatta tgtagtgccg     8220

ccataacgat gagtgataac actgcggcga acttacttct gacaaccatc ggtggaccga     8280

aggaattaac cgcttttttg cacaatatgg gagaccatgt aactcgcctt gaccgttggg     8340

aaccagaact gaatgaagcc ataccaaacg acgagcgaga caccacaatg cctgcggcaa     8400

tggcaacaac attacgcaaa ctattaactg gcgaactact tactctggct tcacggcaac     8460

aattaataga ctggcttgaa gcggataaag ttgcaggacc actactgcgt tcggcacttc     8520

ctgctggctg gtttattgct gataaatctg gggcaggaga gcgtggttca cggggtatca     8580

ttgccgcact tggaccagat ggtaagcctt cccgtatcgt agttatctac acgacgggta     8640

gtcaggcaac tatggacgaa cgaaatagac agattgctga aataggggct tcactgatta     8700

agcattggta aaccgataca attaaaggct ccttttggag cctttttttt tggacggacc     8760

ggtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     8820

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     8880

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt     8940

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     9000

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     9060

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     9120

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     9180

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     9240

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     9300

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     9360

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     9420

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     9480

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     9540

cgaggaagcg gaagagcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc     9600

acaccgcaat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagtat     9660

acactccgct atcgctacgt gactgggtca tggctgcgcc ccgacacccg ccaacacccg     9720

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     9780

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgaggcagc     9840

tgcggtaaag ctcatcagcg tggtcgtgaa gcgattcaca gatgtctgcc tgttcatccg     9900

cgtccagctc gttgagtttc tccagaagcg ttaatgtctg gcttctgata aagcgggcca     9960

tgttaagggc ggttttttcc tgtttggtca ctgatgcctc cgtgtaaggg ggatttctgt    10020

tcatggggta atgataccga tgaaacgaga gaggatgctc acgatacggg ttactgatga    10080

tgaacatgcc cggttactgg aacgttgtga gggtaaacaa ctggcggtat ggatgcggcg    10140

ggaccagaga aaaatcactc agggtcaatg ccagcgcttc gttaatacag atgtaggtgt    10200

t                                                                    10201


<210>  368
<211>  6926
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8, HsCO

<400>  368
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgaat ttgctcattg ataattggat      960

tccggtgcgc ccccggaacg gtgggaaagt gcagatcatc aatttgcaaa gtctctactg     1020

ttccagggac cagtggagac tcagcctgcc acgggatgat atggagctgg cggcgttggc     1080

tctgctcgta tgcatcggcc agattattgc gccagcaaag gatgacgttg aattccggca     1140

tcggataatg aaccccctta ctgaagatga gttccagcag cttatcgccc catggatcga     1200

catgttctac ctcaaccacg ccgagcatcc ttttatgcag accaagggag tcaaggcgaa     1260

tgatgtgact cccatggaga agctgctggc cggtgtatct ggggcgacca actgcgcatt     1320

cgtgaatcag cctggacagg gggaggccct ctgtggaggc tgcactgcta tagcactttt     1380

taaccaagct aatcaagccc ccggctttgg tggagggttt aagagtggat tgaggggggg     1440

cactcccgta accacttttg tgaggggaat tgatctgagg tctactgtgt tgctgaacgt     1500

cctcacactc ccaaggctcc agaagcagtt cccaaacgaa agtcataccg aaaaccagcc     1560

cacatggatc aagcccatca aatctaatga gagcataccg gctagcagta ttggatttgt     1620

acggggtctg ttctggcagc cagctcacat cgagctgtgt gatcctattg ggatcggcaa     1680

gtgctcttgt tgtgggcagg agtccaacct taggtatact ggatttctga aagagaagtt     1740

tacctttaca gtaaatgggc tctggcccca cccccactca ccttgccttg tgacagtgaa     1800

aaagggggaa gtcgaggaga agtttctggc ctttacaact tctgcccctt cctggactca     1860

gatttccaga gtggtggtag ataagataat tcaaaacgag aatggcaata gagtggccgc     1920

cgtggtgaac cagtttcgca acatcgcccc tcagtccccc ctggagctga ttatgggcgg     1980

ttatcggaat aaccaggcca gtatactcga gcgacggcac gatgtcctca tgttcaatca     2040

aggttggcag caatatggca atgtgattaa cgagatcgta accgtgggcc tgggatataa     2100

gaccgccctg cggaaggcgt tgtatacttt tgcagaaggc tttaagaata aggattttaa     2160

gggtgccggc gtgagtgtcc atgaaacagc tgaacggcac ttttatcggc agtccgagct     2220

gttgatacca gacgtgctgg ctaatgtgaa cttctcacag gccgacgaag tgatcgctga     2280

tctgcgggat aaactgcacc aactgtgcga gatgctgttt aatcaaagcg tcgctcctta     2340

tgcccaccac ccaaagctga tctccacgct ggccctggcg cgcgccacac tttataaaca     2400

tctccgcgaa ctgaaacccc aggggggccc cagcaatggc taataacatt ggaagtggat     2460

aatctagagg gccctattct atagtgtcac ctaaatgcta gagctcgctg atcagcctcg     2520

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2580

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2640

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2700

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     2760

agaaccagct ggggctctag ggggtatccc cacgcgccct gtagcggcgc attaagcgcg     2820

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     2880

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     2940

aatcggggca tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     3000

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     3060

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     3120

aaccctatct cggtctattc ttttgattta taagggattt tggggatttc ggcctattgg     3180

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc     3240

agttagggtg tggaaagtcc ccaggctccc caggcaggca gaagtatgca aagcatgcat     3300

ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg     3360

caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg     3420

cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt     3480

tatgcagagg ccgaggccgc ctctgcctct gagctattcc agaagtagtg aggaggcttt     3540

tttggaggcc taggcttttg caaaaagctc ccgggagctt gtatatccat tttcggatct     3600

gatcaagaga caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt     3660

tctccggccg cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc     3720

tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag     3780

accgacctgt ccggtgccct gaatgaactg caggacgagg cagcgcggct atcgtggctg     3840

gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac     3900

tggctgctat tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc     3960

gagaaagtat ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc     4020

tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc     4080

ggtcttgtcg atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg     4140

ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat     4200

gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc     4260

cggctgggtg tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa     4320

gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat     4380

tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgagcggg actctggggt     4440

tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg agatttcgat tccaccgccg     4500

ccttctatga aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc     4560

agcgcgggga tctcatgctg gagttcttcg cccaccccaa cttgtttatt gcagcttata     4620

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     4680

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgt ataccgtcga     4740

cctctagcta gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc     4800

cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4860

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4920

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4980

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     5040

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     5100

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     5160

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     5220

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     5280

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     5340

cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt tcggtgtagg     5400

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5460

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5520

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5580

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5640

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5700

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5760

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5820

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5880

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5940

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     6000

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     6060

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     6120

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     6180

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     6240

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     6300

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6360

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6420

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6480

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6540

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6600

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6660

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6720

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6780

gaatactcat actcttcctt tttcattatt attgaagcat ttatcagggt tattgtctca     6840

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6900

ttccccgaaa agtgccacct gacgtc                                          6926


<210>  369
<211>  6925
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas8, HsCO

<400>  369
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc atgaatttgc      960

tcattgataa ttggattccg gtgcgccccc ggaacggtgg gaaagtgcag atcatcaatt     1020

tgcaaagtct ctactgttcc agggaccagt ggagactcag cctgccacgg gatgatatgg     1080

agctggcggc gttggctctg ctcgtatgca tcggccagat tattgcgcca gcaaaggatg     1140

acgttgaatt ccggcatcgg ataatgaacc cccttactga agatgagttc cagcagctta     1200

tcgccccatg gatcgacatg ttctacctca accacgccga gcatcctttt atgcagacca     1260

agggagtcaa ggcgaatgat gtgactccca tggagaagct gctggccggt gtatctgggg     1320

cgaccaactg cgcattcgtg aatcagcctg gacaggggga ggccctctgt ggaggctgca     1380

ctgctatagc actttttaac caagctaatc aagcccccgg ctttggtgga gggtttaaga     1440

gtggattgag ggggggcact cccgtaacca cttttgtgag gggaattgat ctgaggtcta     1500

ctgtgttgct gaacgtcctc acactcccaa ggctccagaa gcagttccca aacgaaagtc     1560

ataccgaaaa ccagcccaca tggatcaagc ccatcaaatc taatgagagc ataccggcta     1620

gcagtattgg atttgtacgg ggtctgttct ggcagccagc tcacatcgag ctgtgtgatc     1680

ctattgggat cggcaagtgc tcttgttgtg ggcaggagtc caaccttagg tatactggat     1740

ttctgaaaga gaagtttacc tttacagtaa atgggctctg gccccacccc cactcacctt     1800

gccttgtgac agtgaaaaag ggggaagtcg aggagaagtt tctggccttt acaacttctg     1860

ccccttcctg gactcagatt tccagagtgg tggtagataa gataattcaa aacgagaatg     1920

gcaatagagt ggccgccgtg gtgaaccagt ttcgcaacat cgcccctcag tcccccctgg     1980

agctgattat gggcggttat cggaataacc aggccagtat actcgagcga cggcacgatg     2040

tcctcatgtt caatcaaggt tggcagcaat atggcaatgt gattaacgag atcgtaaccg     2100

tgggcctggg atataagacc gccctgcgga aggcgttgta tacttttgca gaaggcttta     2160

agaataagga ttttaagggt gccggcgtga gtgtccatga aacagctgaa cggcactttt     2220

atcggcagtc cgagctgttg ataccagacg tgctggctaa tgtgaacttc tcacaggccg     2280

acgaagtgat cgctgatctg cgggataaac tgcaccaact gtgcgagatg ctgtttaatc     2340

aaagcgtcgc tccttatgcc caccacccaa agctgatctc cacgctggcc ctggcgcgcg     2400

ccacacttta taaacatctc cgcgaactga aaccccaggg gggccccagc aatggctaat     2460

aatctagagg gccctattct atagtgtcac ctaaatgcta gagctcgctg atcagcctcg     2520

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2580

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2640

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2700

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     2760

agaaccagct ggggctctag ggggtatccc cacgcgccct gtagcggcgc attaagcgcg     2820

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     2880

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     2940

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     3000

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     3060

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     3120

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     3180

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc     3240

agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     3300

tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     3360

aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc     3420

ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt     3480

atgcagaggc cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt     3540

ttggaggcct aggcttttgc aaaaagctcc cgggagcttg tatatccatt ttcggatctg     3600

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt     3660

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct     3720

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga     3780

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg     3840

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact     3900

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg     3960

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct     4020

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg     4080

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt     4140

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg     4200

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc     4260

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag     4320

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt     4380

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgagcggga ctctggggtt     4440

cgaaatgacc gaccaagcga cgcccaacct gccatcacga gatttcgatt ccaccgccgc     4500

cttctatgaa aggttgggct tcggaatcgt tttccgggac gccggctgga tgatcctcca     4560

gcgcggggat ctcatgctgg agttcttcgc ccaccccaac ttgtttattg cagcttataa     4620

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     4680

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta taccgtcgac     4740

ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc     4800

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     4860

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     4920

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     4980

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     5040

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     5100

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     5160

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     5220

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     5280

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     5340

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     5400

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     5460

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     5520

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     5580

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     5640

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     5700

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     5760

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     5820

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     5880

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     5940

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     6000

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     6060

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     6120

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     6180

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     6240

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     6300

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     6360

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     6420

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     6480

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     6540

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     6600

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     6660

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     6720

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     6780

aatactcata ctcttccttt ttcattatta ttgaagcatt tatcagggtt attgtctcat     6840

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     6900

tccccgaaaa gtgccacctg acgtc                                           6925


<210>  370
<211>  7630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSHAFokI30aaCas8, HsCO

<400>  370
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggctcaggc tatccctatg      960

acgtacccga ctacgcgcaa ttggtcaaaa gcgaactgga agagaaaaaa tctgagctca     1020

gacacaagct gaagtatgtg ccccatgaat acatagaact catagaaata gctcgaaacc     1080

ccacgcagga ccggatcctt gaaatgaaag ttatggagtt ttttatgaaa gtgtatgggt     1140

atcgaggaga gcatcttggt ggaagtcgga aaccggatgg ggcaatatac actgttggga     1200

gccccattga ctatggtgtg atagtggaca ccaaggcata cagcggggga tacaatctgc     1260

cgatcgggca ggcagatgag atgcagcgct atgtggagga gaatcaaact aggaacaaac     1320

atattaaccc aaacgaatgg tggaaagtgt atccctcatc tgttacggag ttcaagttcc     1380

tttttgtatc tggccacttt aaaggaaact ataaagcaca gctcacgcga cttaaccaca     1440

tcaccaattg taacggtgct gtactcagtg ttgaggaact cctgatcggt ggtgaaatga     1500

taaaagctgg aaccttgaca ttggaggaag taaggagaaa gtttaataat ggtgagatca     1560

atttcagcgg ctccgaaacg ccgggtacat ccgagtccgc gactcctgag tcaggaggca     1620

gcggctcctc tggtggaagc ggctcaagtg gagggatgaa tttgctcatt gataattgga     1680

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     1740

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     1800

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     1860

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     1920

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     1980

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     2040

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     2100

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     2160

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     2220

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     2280

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     2340

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     2400

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     2460

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     2520

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     2580

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     2640

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     2700

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     2760

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     2820

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     2880

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     2940

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     3000

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     3060

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     3120

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     3180

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     3240

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     3300

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     3360

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     3420

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     3480

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     3540

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     3600

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     3660

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     3720

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     3780

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     3840

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     3900

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     3960

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     4020

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     4080

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     4140

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     4200

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     4260

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     4320

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     4380

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     4440

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     4500

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     4560

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     4620

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     4680

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     4740

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg     4800

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg     4860

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata     4920

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg     4980

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat     5040

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct     5100

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca     5160

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt     5220

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat     5280

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag     5340

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     5400

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt     5460

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca     5520

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact     5580

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct     5640

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc     5700

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     5760

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     5820

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     5880

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     5940

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     6000

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     6060

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     6120

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     6180

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     6240

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     6300

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     6360

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     6420

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     6480

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     6540

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     6600

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     6660

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat     6720

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc     6780

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag     6840

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag     6900

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt     6960

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg     7020

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt     7080

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc     7140

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc     7200

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa     7260

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg     7320

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc     7380

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag     7440

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt     7500

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     7560

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     7620

acctgacgtc                                                            7630


<210>  371
<211>  5933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCse2, HsCO

<400>  371
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgccg aaaaaaaagc ggaaggtcgg      960

atcaggaatg gccgacgaga ttgacgcaat ggcactttac cgggcctggc agcagttgga     1020

taatggttca tgtgcccaga ttcgcagagt tagtgaacct gacgaactga gagatatccc     1080

cgcgttttac agacttgtcc aaccgttcgg atgggagaac ccacggcacc aacaagcact     1140

ccttcgaatg gtcttctgtt tgtccgcagg aaaaaatgta atcagacacc aagacaaaaa     1200

gagcgagcaa accacaggta tcagcctggg cagggcactt gccaactctg ggcggatcaa     1260

cgaaaggaga atttttcagc tgatacgcgc tgatcggact gcggacatgg tgcagctgcg     1320

cagactcctt actcatgccg aacctgtcct ggattggccc ctgatggcac gcatgctgac     1380

ttggtgggga aagagagaaa gacagcaact gcttgaagac ttcgtgctca ctacaaataa     1440

gaatgcctaa taacattgga agtggataat ctagagggcc ctattctata gtgtcaccta     1500

aatgctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     1560

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     1620

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     1680

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     1740

gtgggctcta tggcttctga ggcggaaaga accagctggg gctctagggg gtatccccac     1800

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct     1860

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg     1920

ttcgccggct ttccccgtca agctctaaat cggggcatcc ctttagggtt ccgatttagt     1980

gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca     2040

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga     2100

ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa     2160

gggattttgg ggatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac     2220

gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag     2280

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     2340

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     2400

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     2460

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag     2520

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg     2580

ggagcttgta tatccatttt cggatctgat caagagacag gatgaggatc gtttcgcatg     2640

attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc     2700

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     2760

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag     2820

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     2880

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     2940

ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     3000

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc     3060

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag     3120

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc     3180

gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc     3240

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata     3300

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc     3360

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac     3420

gagttcttct gagcgggact ctggggttcg aaatgaccga ccaagcgacg cccaacctgc     3480

catcacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc ggaatcgttt     3540

tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag ttcttcgccc     3600

accccaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     3660

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     3720

tatcttatca tgtctgtata ccgtcgacct ctagctagag cttggcgtaa tcatggtcat     3780

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa     3840

gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc     3900

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     3960

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     4020

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     4080

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     4140

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     4200

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     4260

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     4320

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct caatgctcac     4380

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     4440

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     4500

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     4560

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     4620

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     4680

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     4740

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     4800

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     4860

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     4920

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     4980

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     5040

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     5100

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     5160

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     5220

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     5280

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     5340

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     5400

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     5460

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     5520

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     5580

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     5640

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     5700

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     5760

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt cattattatt     5820

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     5880

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtc            5933


<210>  372
<211>  6542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas7, HsCO

<400>  372
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgccg aaaaaaaagc ggaaggtcgg      960

atcaggaatg tcaaatttta ttaatattca tgttctgatc agtcatagcc cgagttgcct     1020

gaatagagac gacatgaata tgcagaaaga cgcaattttc ggtggcaaga ggcgagtccg     1080

aataagcagc caaagtctta agcgagccat gaggaagagc ggctattatg cccagaatat     1140

cggcgagtcc tcattgcgga ccatccacct cgcccagttg agagacgtct tgaggcagaa     1200

actgggggaa agattcgacc agaaaatcat tgacaagacc cttgccctcc ttagtgggaa     1260

gagcgtggac gaggctgaaa aaatctctgc cgacgccgta acgccctggg ttgtgggtga     1320

gattgcttgg ttttgtgaac aggtggcgaa ggcggaggcc gataacctgg atgacaagaa     1380

gctgctgaag gtccttaagg aggacatagc tgccattcgg gtcaatttgc agcagggagt     1440

ggatatcgca ttgtccggaa gaatggctac atcaggcatg atgaccgagc tgggcaaggt     1500

agacggagcc atgagtatcg cacacgccat caccacccac caagtcgact cagacatcga     1560

ctggttcaca gcagtagatg acctccagga gcaggggtct gcccaccttg ggacacagga     1620

gttctcttcc ggggtgtttt atcgctatgc taatatcaat ctggcgcagc tgcaagaaaa     1680

cctgggggga gcctctcgag agcaggccct ggagattgca actcacgtcg tgcatatgct     1740

tgcgacagag gtacctggcg ccaagcagag gacatacgct gcttttaatc cagcagatat     1800

ggtcatggta aatttctctg atatgcctct ctccatggcc aacgcattcg agaaggcagt     1860

gaaggcaaag gacgggttcc tgcagccatc aattcaagcg tttaatcagt attgggacag     1920

agtggcgaac ggctatggac tgaacggagc cgcagctcag tttagcctca gcgatgtcga     1980

tcccataact gcacaggtga aacagatgcc tacgttggaa cagctgaagt catgggtaag     2040

aaataacggc gaagcctaat aacattggaa gtggataatc tagagggccc tattctatag     2100

tgtcacctaa atgctagagc tcgctgatca gcctcgactg tgccttctag ttgccagcca     2160

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     2220

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     2280

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     2340

ggggatgcgg tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctctaggggg     2400

tatccccacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc     2460

gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt     2520

ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc ggggcatccc tttagggttc     2580

cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt     2640

agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt     2700

aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt     2760

gatttataag ggattttggg gatttcggcc tattggttaa aaaatgagct gatttaacaa     2820

aaatttaacg cgaattaatt ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag     2880

gctccccagg caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2940

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     3000

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3060

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctct     3120

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3180

aagctcccgg gagcttgtat atccattttc ggatctgatc aagagacagg atgaggatcg     3240

tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg     3300

ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg     3360

ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat     3420

gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca     3480

gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg     3540

gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat     3600

gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa     3660

catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg     3720

gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg     3780

cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg     3840

gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat     3900

caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac     3960

cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc     4020

cttcttgacg agttcttctg agcgggactc tggggttcga aatgaccgac caagcgacgc     4080

ccaacctgcc atcacgagat ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg     4140

gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc atgctggagt     4200

tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     4260

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     4320

tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc ttggcgtaat     4380

catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac     4440

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa     4500

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     4560

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc     4620

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg     4680

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag     4740

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     4800

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     4860

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     4920

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     4980

aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     5040

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     5100

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     5160

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     5220

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     5280

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     5340

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     5400

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa     5460

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta     5520

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag     5580

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga     5640

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac     5700

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc     5760

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta     5820

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac     5880

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat     5940

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa     6000

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg     6060

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag     6120

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     6180

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     6240

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat     6300

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg     6360

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc     6420

attattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta     6480

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg     6540

tc                                                                    6542


<210>  373
<211>  6092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas5, HsCO

<400>  373
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgcgg agctatctca tcctgagact      960

ggccggacca atgcaggcct ggggacagcc taccttcgaa ggtacacgcc ccacaggccg     1020

ctttcctacc aggagcggcc tgctgggcct gcttggcgct tgtcttggga tccagcgcga     1080

tgatactagc tccctgcaag cactgtcaga gagcgtgcag tttgccgtaa gatgcgacga     1140

actgatcctt gatgataggc gggtcagtgt cactggtctc cgggactacc acacggtgct     1200

gggggcccgg gaggattata ggggcctgaa aagtcacgag acgattcaaa cctggcgcga     1260

atatctgtgc gatgccagct tcaccgtggc cctgtggctg actccacatg ccactatggt     1320

catcagtgaa ctggaaaagg ctgttcttaa gcctcgatat actccgtatc tgggccgccg     1380

gagttgtcca cttacacacc cacttttcct cggcacctgc caggccagcg accctcaaaa     1440

ggcccttctg aattacgagc cagttggcgg tgacatatac agcgaagagt ccgtgacggg     1500

acaccatctt aagttcaccg ctcgggacga gcccatgatt accctcccac ggcagttcgc     1560

atcaagggag tggtacgtca taaagggggg catggatgtg agtcagtaat aacattggaa     1620

gtggataatc tagagggccc tattctatag tgtcacctaa atgctagagc tcgctgatca     1680

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     1740

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     1800

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     1860

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     1920

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     1980

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2040

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2100

gctctaaatc ggggcatccc tttagggttc cgatttagtg ctttacggca cctcgacccc     2160

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2220

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     2280

acactcaacc ctatctcggt ctattctttt gatttataag ggattttggg gatttcggcc     2340

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     2400

tgtgtcagtt agggtgtgga aagtccccag gctccccagg caggcagaag tatgcaaagc     2460

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga     2520

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     2580

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     2640

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga     2700

ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc     2760

ggatctgatc aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac     2820

gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca     2880

atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt     2940

gtcaagaccg acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg     3000

tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga     3060

agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct     3120

cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg     3180

gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg     3240

gaagccggtc ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc     3300

gaactgttcg ccaggctcaa ggcgcgcatg cccgacggcg aggatctcgt cgtgacccat     3360

ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac     3420

tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt     3480

gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct     3540

cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg agcgggactc     3600

tggggttcga aatgaccgac caagcgacgc ccaacctgcc atcacgagat ttcgattcca     3660

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga     3720

tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag     3780

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     3840

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac     3900

cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt     3960

gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg     4020

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt     4080

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     4140

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     4200

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     4260

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     4320

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     4380

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     4440

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     4500

ttctcccttc gggaagcgtg gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg     4560

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     4620

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     4680

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     4740

tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc     4800

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     4860

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     4920

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     4980

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     5040

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     5100

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     5160

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     5220

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     5280

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     5340

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     5400

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     5460

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     5520

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     5580

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     5640

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     5700

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     5760

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     5820

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     5880

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     5940

aatgttgaat actcatactc ttcctttttc attattattg aagcatttat cagggttatt     6000

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     6060

gcacatttcc ccgaaaagtg ccacctgacg tc                                   6092


<210>  374
<211>  6091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas5, HsCO

<400>  374
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc atgcggagct      960

atctcatcct gagactggcc ggaccaatgc aggcctgggg acagcctacc ttcgaaggta     1020

cacgccccac aggccgcttt cctaccagga gcggcctgct gggcctgctt ggcgcttgtc     1080

ttgggatcca gcgcgatgat actagctccc tgcaagcact gtcagagagc gtgcagtttg     1140

ccgtaagatg cgacgaactg atccttgatg ataggcgggt cagtgtcact ggtctccggg     1200

actaccacac ggtgctgggg gcccgggagg attatagggg cctgaaaagt cacgagacga     1260

ttcaaacctg gcgcgaatat ctgtgcgatg ccagcttcac cgtggccctg tggctgactc     1320

cacatgccac tatggtcatc agtgaactgg aaaaggctgt tcttaagcct cgatatactc     1380

cgtatctggg ccgccggagt tgtccactta cacacccact tttcctcggc acctgccagg     1440

ccagcgaccc tcaaaaggcc cttctgaatt acgagccagt tggcggtgac atatacagcg     1500

aagagtccgt gacgggacac catcttaagt tcaccgctcg ggacgagccc atgattaccc     1560

tcccacggca gttcgcatca agggagtggt acgtcataaa ggggggcatg gatgtgagtc     1620

agtaataatc tagagggccc tattctatag tgtcacctaa atgctagagc tcgctgatca     1680

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     1740

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     1800

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     1860

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     1920

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     1980

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2040

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2100

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     2160

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2220

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     2280

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     2340

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     2400

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     2460

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     2520

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     2580

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     2640

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     2700

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     2760

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     2820

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     2880

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     2940

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     3000

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     3060

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     3120

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     3180

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     3240

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     3300

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     3360

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     3420

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     3480

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     3540

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     3600

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     3660

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     3720

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     3780

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3840

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     3900

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     3960

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     4020

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     4080

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     4140

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     4200

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     4260

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     4320

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     4380

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     4440

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     4500

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     4560

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     4620

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     4680

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     4740

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     4800

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     4860

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     4920

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     4980

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     5040

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     5100

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     5160

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     5220

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     5280

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     5340

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     5400

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     5460

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     5520

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     5580

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     5640

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     5700

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     5760

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     5820

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     5880

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     5940

atgttgaata ctcatactct tcctttttca ttattattga agcatttatc agggttattg     6000

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     6060

cacatttccc cgaaaagtgc cacctgacgt c                                    6091


<210>  375
<211>  6017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas6, HsCO

<400>  375
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgtat ctgtcaaagg ttatcattgc      960

acgcgcgtgg agtagggatc tgtatcagct gcaccagggt ctgtggcatc ttttcccgaa     1020

ccgccccgac gcggcacgag actttctgtt tcacgttgaa aaaagaaaca cccccgaggg     1080

ctgtcatgtg ctcctgcagt ctgcccagat gccggtgagc acagctgtgg cgactgtgat     1140

caagaccaag caggtcgagt ttcagctcca ggtaggggtt ccactgtatt ttcgcctgag     1200

agctaatccg atcaaaacca tactggataa tcagaagagg ctcgacagca aaggaaatat     1260

taaaaggtgc cgggtcccgc tcatcaaaga ggctgagcaa atcgcttggc ttcaacggaa     1320

actggggaac gcagcccgcg tggaagacgt ccacccgatt agtgaacggc cccaatattt     1380

ttccggagac ggaaagagcg gcaagattca gacagtctgt ttcgaggggg tgctcaccat     1440

caatgatgcc cccgccctga tagacctggt gcagcagggc ataggccccg ctaaaagcat     1500

gggatgcgga ctgcttagtc tggcaccgct gtaataacat tggaagtgga taatctagag     1560

ggccctattc tatagtgtca cctaaatgct agagctcgct gatcagcctc gactgtgcct     1620

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     1680

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     1740

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     1800

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc     1860

tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     1920

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     1980

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggc     2040

atccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag     2100

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     2160

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     2220

tcggtctatt cttttgattt ataagggatt ttggggattt cggcctattg gttaaaaaat     2280

gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt     2340

gtggaaagtc cccaggctcc ccaggcaggc agaagtatgc aaagcatgca tctcaattag     2400

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     2460

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     2520

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     2580

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     2640

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag     2700

acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc     2760

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     2820

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     2880

tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg     2940

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3000

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3060

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3120

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3180

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3240

ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3300

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3360

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3420

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3480

atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga     3540

ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg     3600

aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg     3660

atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca     3720

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     3780

gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct     3840

agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     3900

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     3960

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     4020

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4080

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4140

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4200

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4260

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4320

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4380

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4440

gcgtggcgct ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4500

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4560

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4620

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4680

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta     4740

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg     4800

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt     4860

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg     4920

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta     4980

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg     5040

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg     5100

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc     5160

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     5220

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     5280

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     5340

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     5400

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     5460

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     5520

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     5580

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     5640

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     5700

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     5760

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     5820

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     5880

tactcttcct ttttcattat tattgaagca tttatcaggg ttattgtctc atgagcggat     5940

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     6000

aagtgccacc tgacgtc                                                    6017


<210>  376
<211>  6016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas6, HsCO

<400>  376
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc atgtatctgt      960

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     1020

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     1080

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     1140

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     1200

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     1260

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     1320

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     1380

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     1440

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     1500

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctgtaa taatctagag     1560

ggccctattc tatagtgtca cctaaatgct agagctcgct gatcagcctc gactgtgcct     1620

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     1680

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     1740

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     1800

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc     1860

tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     1920

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     1980

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg     2040

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag     2100

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     2160

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     2220

tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat     2280

gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt     2340

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     2400

cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc     2460

atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc     2520

cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg     2580

ccgaggccgc ctctgcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc     2640

taggcttttg caaaaagctc ccgggagctt gtatatccat tttcggatct gatcaagaga     2700

caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg     2760

cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg     2820

ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt     2880

ccggtgccct gaatgaactg caggacgagg cagcgcggct atcgtggctg gccacgacgg     2940

gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat     3000

tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat     3060

ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg     3120

accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg     3180

atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc     3240

tcaaggcgcg catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc     3300

cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg     3360

tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg     3420

gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca     3480

tcgccttcta tcgccttctt gacgagttct tctgagcggg actctggggt tcgaaatgac     3540

cgaccaagcg acgcccaacc tgccatcacg agatttcgat tccaccgccg ccttctatga     3600

aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga     3660

tctcatgctg gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa     3720

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     3780

tggtttgtcc aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta     3840

gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat     3900

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag     3960

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg     4020

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc     4080

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     4140

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     4200

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     4260

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     4320

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     4380

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     4440

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     4500

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     4560

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     4620

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     4680

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     4740

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     4800

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     4860

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     4920

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     4980

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga     5040

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt     5100

gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg     5160

agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga     5220

gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga     5280

agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg     5340

catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc     5400

aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc     5460

gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca     5520

taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac     5580

caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg     5640

ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc     5700

ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg     5760

tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac     5820

aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat     5880

actcttcctt tttcattatt attgaagcat ttatcagggt tattgtctca tgagcggata     5940

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa     6000

agtgccacct gacgtc                                                     6016


<210>  377
<211>  6736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSV5FokI30aaCas8, HsCO

<400>  377
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggctcaggc ggtaaaccca      960

tcccaaaccc cttgcttggt ctcgactcaa cccaattggt caaaagcgaa ctggaagaga     1020

aaaaatctga gctcagacac aagctgaagt atgtgcccca tgaatacata gaactcatag     1080

aaatagctcg aaaccccacg caggaccgga tccttgaaat gaaagttatg gagtttttta     1140

tgaaagtgta tgggtatcga ggagagcatc ttggtggaag tcggaaaccg gatggggcaa     1200

tatacactgt tgggagcccc attgactatg gtgtgatagt ggacaccaag gcatacagcg     1260

ggggatacaa tctgccgatc gggcaggcag atgagatgca gcgctatgtg gaggagaatc     1320

aaactaggaa caaacatatt aacccaaacg aatggtggaa agtgtatccc tcatctgtta     1380

cggagttcaa gttccttttt gtatctggcc actttaaagg aaactataaa gcacagctca     1440

cgcgacttaa ccacatcacc aattgtaacg gtgctgtact cagtgttgag gaactcctga     1500

tcggtggtga aatgataaaa gctggaacct tgacattgga ggaagtaagg agaaagttta     1560

ataatggtga gatcaatttc agcggctccg aaacgccggg tacatccgag tccgcgactc     1620

ctgagtcagg aggcagcggc tcctctggtg gaagcggctc aagtggaggg atgtatctgt     1680

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     1740

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     1800

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     1860

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     1920

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     1980

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     2040

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     2100

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     2160

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     2220

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctgtaa taatctagag     2280

ggccctattc tatagtgtca cctaaatgct agagctcgct gatcagcctc gactgtgcct     2340

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     2400

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     2460

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     2520

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc     2580

tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     2640

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     2700

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg     2760

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag     2820

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     2880

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     2940

tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat     3000

gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt     3060

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     3120

cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc     3180

atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc     3240

cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg     3300

ccgaggccgc ctctgcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc     3360

taggcttttg caaaaagctc ccgggagctt gtatatccat tttcggatct gatcaagaga     3420

caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg     3480

cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg     3540

ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt     3600

ccggtgccct gaatgaactg caggacgagg cagcgcggct atcgtggctg gccacgacgg     3660

gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat     3720

tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat     3780

ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg     3840

accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg     3900

atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc     3960

tcaaggcgcg catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc     4020

cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg     4080

tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg     4140

gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca     4200

tcgccttcta tcgccttctt gacgagttct tctgagcggg actctggggt tcgaaatgac     4260

cgaccaagcg acgcccaacc tgccatcacg agatttcgat tccaccgccg ccttctatga     4320

aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga     4380

tctcatgctg gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa     4440

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     4500

tggtttgtcc aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta     4560

gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat     4620

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag     4680

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg     4740

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc     4800

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     4860

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     4920

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     4980

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     5040

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     5100

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     5160

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     5220

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     5280

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     5340

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     5400

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     5460

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     5520

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     5580

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     5640

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     5700

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga     5760

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt     5820

gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg     5880

agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga     5940

gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga     6000

agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg     6060

catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc     6120

aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc     6180

gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca     6240

taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac     6300

caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg     6360

ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc     6420

ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg     6480

tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac     6540

aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat     6600

actcttcctt tttcattatt attgaagcat ttatcagggt tattgtctca tgagcggata     6660

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa     6720

agtgccacct gacgtc                                                     6736


<210>  378
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3NLS, HsCO

<400>  378
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatggag ccttttaaat atatttgtca      960

ttactggggt aagagttcca agagcctgac aaaaggcaat gatatacatc ttttgatcta     1020

tcactgtctc gacgtcgcag cggtagcgga ttgctggtgg gatcaaagtg tcgtgctcca     1080

gaacacgttt tgtcgaaacg aaatgctcag caagcagcgg gtaaaagcat ggctcctttt     1140

ctttattgct ctccacgaca taggcaaatt cgacattagg ttccagtaca aatctgcaga     1200

gagttggttg aaattgaacc cggccacccc tagcctgaac ggcccttcaa ctcagatgtg     1260

caggaaattt aaccatggag ccgctgggtt gtattggttt aatcaggaca gtttgtcaga     1320

gcaaagtctg ggggatttct tctccttttt tgacgccgcg cctcatcctt acgagagctg     1380

gtttccatgg gtcgaggccg tcacagggca ccatggcttt attcttcact ctcaggacca     1440

agacaaatct cgatgggaaa tgcctgccag tctggcgtct tacgccgcgc aggataagca     1500

agcacgagaa gaatggattt ccgtcttgga ggcgctgttt ctcacacccg ccgggctctc     1560

tatcaacgac ataccccccg attgctctag tctgcttgcc ggtttttgct cccttgccga     1620

ttggcttggt tcatggacga ccaccaatac gtttttgttc aatgaagatg caccatctga     1680

tataaatgca ttgaggacgt attttcaaga cagacagcaa gatgcctcca gagttttgga     1740

gctttctgga cttgtatcaa ataagagatg ctacgaagga gtgcatgctc tgctggacaa     1800

cggctaccag ccacgacaac ttcaagttct cgttgatgcc ctcccggtgg ctccggggtt     1860

gaccgtcata gaggcgccta ctggatcagg gaagaccgag acagccttgg cctatgcgtg     1920

gaaactgata gatcaacaga ttgccgactc agtgatcttc gcgctgccaa ctcaggcaac     1980

agccaacgcg atgctgacac gcatggaggc cagcgcaagt caccttttct ctagtccaaa     2040

tctgatactg gcccatggta attctaggtt taaccatctg tttcagtcca tcaagtctag     2100

ggcgataact gagcaaggac aggaagaagc ctgggttcaa tgctgccagt ggcttagcca     2160

gagtaacaag aaagtattct tgggacagat tggtgtctgc acaatagacc aagtactcat     2220

ctcagttttg cctgttaagc accgattcat acgaggactt ggaatcgggc gcagtgtcct     2280

catagtagat gaggtgcatg cttacgacac ctacatgaac ggtttgctcg aggcggtgct     2340

caaagcacaa gctgatgtcg gaggtagcgt gatccttctc agcgctacgc ttcctatgaa     2400

acagaagcag aagttgctcg atacctatgg tctgcatacg gatcctgtgg aaaataatag     2460

tgcctacccc ctcataaact ggaggggagt aaatggtgca cagaggtttg accttcttgc     2520

tcaccctgag cagcttcctc cccggttttc catacagccg gagccgattt gtcttgccga     2580

catgcttcca gatctcacaa tgctcgaacg gatgatcgcg gccgctaatg ccggcgcaca     2640

agtctgtctc atctgtaacc ttgtcgatgt agcgcaggtt tgttaccaac gactcaaaga     2700

actgaataat acacaagtag acatagatct gttccatgct cgctttacac tcaatgacag     2760

aagggaaaaa gaaaatcggg tcatctcaaa ttttggtaag aacggaaaac gaaacgttgg     2820

ccgaatcctc gtcgcaaccc aggtagtgga gcagtccctc gatgtggact ttgactggct     2880

tattacacag cactgccctg ctgacctcct gttccagcga cttggcagat tgcatagaca     2940

tcaccggaaa tatcggcctg caggttttga gataccagtc gcaactattc ttctccccga     3000

cggggaaggg tacgggcgac acgagcacat ctatagcaac gtacgggtaa tgtggcggac     3060

gcaacaacac atcgaggaac ttaacggagc atccctgttt ttccccgatg cctatagaca     3120

atggctcgac agtatttatg atgacgccga aatggacgaa cccgagtggg tcggaaatgg     3180

tatggataaa tttgaatccg cagaatgtga aaaacggttc aaagcacgga aggtcctcca     3240

gtgggctgag gagtattcat tgcaggataa cgacgaaacc atcttggctg tcactagaga     3300

cggcgaaatg tcccttccac tgcttcctta tgttcaaacc tcttctggga aacagcttct     3360

tgatggccag gtatatgagg acctgtccca cgaacaacag tacgaggcac ttgccttgaa     3420

ccgcgttaat gtacctttca cttggaaacg atcattttca gaggtcgtag atgaagatgg     3480

gctcctttgg ctggaaggca aacaaaacct ggatggatgg gtatggcagg gaaactctat     3540

tgtaataaca tacactggcg atgagggtat gacgagggtt ataccggcga atccgaaatc     3600

cgggtcaccc aaaaagaaga gaaaagtata ataacattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  379
<211>  4804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(Hsa07)

<400>  379
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc ctcaccgagg gcctatttcc      240

catgattcct tcatatttgc atatacgata caaggctgtt agagagataa ttggaattaa      300

tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt aataatttct      360

tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc ttaccgtaac      420

ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa acaccgagtt      480

ccccgcgcca gcggggataa accggttgat ttgcctgcat tggtgttaca cagtctgagt      540

tccccgcgcc agcggggata aaccgtaagt tgtgttcttc tttgcctagg ccttcaggag      600

ttccccgcgc cagcggggat aaaccgtttt tttcggaaag aaccagctgg ggctctaggg      660

ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca      720

gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct      780

ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc cctttagggt      840

tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac      900

gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct      960

ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt     1020

ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag ctgatttaac     1080

aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc     1140

aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccaggt     1200

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     1260

cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg     1320

cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct     1380

ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca     1440

aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca ggatgaggat     1500

cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga     1560

ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc     1620

ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga     1680

atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg     1740

cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc     1800

cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg     1860

atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga     1920

aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc     1980

tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgcgca     2040

tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg     2100

tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct     2160

atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg     2220

accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc     2280

gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg accaagcgac     2340

gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa ggttgggctt     2400

cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc tcatgctgga     2460

gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat aaagcaatag     2520

catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa     2580

actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga gcttggcgta     2640

atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat     2700

acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt     2760

aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta     2820

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc     2880

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     2940

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     3000

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     3060

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     3120

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     3180

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     3240

tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     3300

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     3360

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     3420

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     3480

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     3540

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     3600

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     3660

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     3720

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     3780

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     3840

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     3900

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     3960

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     4020

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     4080

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     4140

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     4200

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     4260

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     4320

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     4380

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     4440

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     4500

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     4560

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     4620

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     4680

tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     4740

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     4800

cgtc                                                                  4804


<210>  380
<211>  8701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polycistronic(HsCO), NLSCas7_NLSCse2_NLSCas5_NLSCas6

<400>  380
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc gaacagaaac      960

ttatatctga ggaggacctc ggatcgggca tgtcaaattt tattaatatt catgttctga     1020

tcagtcatag cccgagttgc ctgaatagag acgacatgaa tatgcagaaa gacgcaattt     1080

tcggtggcaa gaggcgagtc cgaataagca gccaaagtct taagcgagcc atgaggaaga     1140

gcggctatta tgcccagaat atcggcgagt cctcattgcg gaccatccac ctcgcccagt     1200

tgagagacgt cttgaggcag aaactggggg aaagattcga ccagaaaatc attgacaaga     1260

cccttgccct ccttagtggg aagagcgtgg acgaggctga aaaaatctct gccgacgccg     1320

taacgccctg ggttgtgggt gagattgctt ggttttgtga acaggtggcg aaggcggagg     1380

ccgataacct ggatgacaag aagctgctga aggtccttaa ggaggacata gctgccattc     1440

gggtcaattt gcagcaggga gtggatatcg cattgtccgg aagaatggct acatcaggca     1500

tgatgaccga gctgggcaag gtagacggag ccatgagtat cgcacacgcc atcaccaccc     1560

accaagtcga ctcagacatc gactggttca cagcagtaga tgacctccag gagcaggggt     1620

ctgcccacct tgggacacag gagttctctt ccggggtgtt ttatcgctat gctaatatca     1680

atctggcgca gctgcaagaa aacctggggg gagcctctcg agagcaggcc ctggagattg     1740

caactcacgt cgtgcatatg cttgcgacag aggtacctgg cgccaagcag aggacatacg     1800

ctgcttttaa tccagcagat atggtcatgg taaatttctc tgatatgcct ctctccatgg     1860

ccaacgcatt cgagaaggca gtgaaggcaa aggacgggtt cctgcagcca tcaattcaag     1920

cgtttaatca gtattgggac agagtggcga acggctatgg actgaacgga gccgcagctc     1980

agtttagcct cagcgatgtc gatcccataa ctgcacaggt gaaacagatg cctacgttgg     2040

aacagctgaa gtcatgggta agaaataacg gcgaagccgg cagcggcgag ggcagaggca     2100

gcctgctgac ctgcggcgac gtggaggaga accccggccc ccccaagaaa aagagaaaag     2160

taggatcggg cgattacaaa gatcacgatg gggactacaa ggatcacgat attgactata     2220

aggacgacga tgacaaggga tcgggcatgg ccgacgagat tgacgcaatg gcactttacc     2280

gggcctggca gcagttggat aatggttcat gtgcccagat tcgcagagtt agtgaacctg     2340

acgaactgag agatatcccc gcgttttaca gacttgtcca accgttcgga tgggagaacc     2400

cacggcacca acaagcactc cttcgaatgg tcttctgttt gtccgcagga aaaaatgtaa     2460

tcagacacca agacaaaaag agcgagcaaa ccacaggtat cagcctgggc agggcacttg     2520

ccaactctgg gcggatcaac gaaaggagaa tttttcagct gatacgcgct gatcggactg     2580

cggacatggt gcagctgcgc agactcctta ctcatgccga acctgtcctg gattggcccc     2640

tgatggcacg catgctgact tggtggggaa agagagaaag acagcaactg cttgaagact     2700

tcgtgctcac tacaaataag aatgccggat ccggagaagg aaggggatcc ctcctcacat     2760

gtggagatgt cgaagaaaat cctggacctc ccaagaaaaa gagaaaagta ggatcgggca     2820

tgcggagcta tctcatcctg agactggccg gaccaatgca ggcctgggga cagcctacct     2880

tcgaaggtac acgccccaca ggccgctttc ctaccaggag cggcctgctg ggcctgcttg     2940

gcgcttgtct tgggatccag cgcgatgata ctagctccct gcaagcactg tcagagagcg     3000

tgcagtttgc cgtaagatgc gacgaactga tccttgatga taggcgggtc agtgtcactg     3060

gtctccggga ctaccacacg gtgctggggg cccgggagga ttataggggc ctgaaaagtc     3120

acgagacgat tcaaacctgg cgcgaatatc tgtgcgatgc cagcttcacc gtggccctgt     3180

ggctgactcc acatgccact atggtcatca gtgaactgga aaaggctgtt cttaagcctc     3240

gatatactcc gtatctgggc cgccggagtt gtccacttac acacccactt ttcctcggca     3300

cctgccaggc cagcgaccct caaaaggccc ttctgaatta cgagccagtt ggcggtgaca     3360

tatacagcga agagtccgtg acgggacacc atcttaagtt caccgctcgg gacgagccca     3420

tgattaccct cccacggcag ttcgcatcaa gggagtggta cgtcataaag gggggcatgg     3480

atgtgagtca ggggtctggg gaggggcggg ggtctttgtt gacttgcggg gatgttgagg     3540

agaacccagg gccacccaag aaaaagagaa aagtaggctc aggcggtaaa cccatcccaa     3600

accccttgct tggtctcgac tcaaccggat cgggcatgta tctgtcaaag gttatcattg     3660

cacgcgcgtg gagtagggat ctgtatcagc tgcaccaggg tctgtggcat cttttcccga     3720

accgccccga cgcggcacga gactttctgt ttcacgttga aaaaagaaac acccccgagg     3780

gctgtcatgt gctcctgcag tctgcccaga tgccggtgag cacagctgtg gcgactgtga     3840

tcaagaccaa gcaggtcgag tttcagctcc aggtaggggt tccactgtat tttcgcctga     3900

gagctaatcc gatcaaaacc atactggata atcagaagag gctcgacagc aaaggaaata     3960

ttaaaaggtg ccgggtcccg ctcatcaaag aggctgagca aatcgcttgg cttcaacgga     4020

aactggggaa cgcagcccgc gtggaagacg tccacccgat tagtgaacgg ccccaatatt     4080

tttccggaga cggaaagagc ggcaagattc agacagtctg tttcgagggg gtgctcacca     4140

tcaatgatgc ccccgccctg atagacctgg tgcagcaggg cataggcccc gctaaaagca     4200

tgggatgcgg actgcttagt ctggcaccgc tgtaataatc tagagggccc tattctatag     4260

tgtcacctaa atgctagagc tcgctgatca gcctcgactg tgccttctag ttgccagcca     4320

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     4380

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     4440

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     4500

ggggatgcgg tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctctaggggg     4560

tatccccacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc     4620

gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt     4680

ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc     4740

cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt     4800

agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt     4860

aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt     4920

gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa     4980

aaatttaacg cgaattaatt ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag     5040

gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accaggtgtg     5100

gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag     5160

caaccatagt cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc     5220

attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctctg     5280

cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa     5340

agctcccggg agcttgtata tccattttcg gatctgatca agagacagga tgaggatcgt     5400

ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc     5460

tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc     5520

tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg     5580

aactgcagga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag     5640

ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg     5700

ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg     5760

caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac     5820

atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg     5880

acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc     5940

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg     6000

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc     6060

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc     6120

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc     6180

ttcttgacga gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc     6240

caacctgcca tcacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg     6300

aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt     6360

cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     6420

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     6480

catcaatgta tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc     6540

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     6600

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     6660

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     6720

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     6780

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     6840

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     6900

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     6960

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     7020

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     7080

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     7140

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     7200

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     7260

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     7320

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     7380

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     7440

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     7500

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     7560

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     7620

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     7680

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     7740

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     7800

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     7860

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     7920

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     7980

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     8040

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     8100

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     8160

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     8220

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     8280

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     8340

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     8400

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     8460

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     8520

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     8580

ttattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     8640

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt     8700

c                                                                     8701


<210>  381
<211>  10300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polycistronic(HsCO), 
       NLSCas7_NLSCse2_NLSCas5_NLSCas6_NLSCas8

<400>  381
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc gaacagaaac      960

ttatatctga ggaggacctc ggatcgggca tgtcaaattt tattaatatt catgttctga     1020

tcagtcatag cccgagttgc ctgaatagag acgacatgaa tatgcagaaa gacgcaattt     1080

tcggtggcaa gaggcgagtc cgaataagca gccaaagtct taagcgagcc atgaggaaga     1140

gcggctatta tgcccagaat atcggcgagt cctcattgcg gaccatccac ctcgcccagt     1200

tgagagacgt cttgaggcag aaactggggg aaagattcga ccagaaaatc attgacaaga     1260

cccttgccct ccttagtggg aagagcgtgg acgaggctga aaaaatctct gccgacgccg     1320

taacgccctg ggttgtgggt gagattgctt ggttttgtga acaggtggcg aaggcggagg     1380

ccgataacct ggatgacaag aagctgctga aggtccttaa ggaggacata gctgccattc     1440

gggtcaattt gcagcaggga gtggatatcg cattgtccgg aagaatggct acatcaggca     1500

tgatgaccga gctgggcaag gtagacggag ccatgagtat cgcacacgcc atcaccaccc     1560

accaagtcga ctcagacatc gactggttca cagcagtaga tgacctccag gagcaggggt     1620

ctgcccacct tgggacacag gagttctctt ccggggtgtt ttatcgctat gctaatatca     1680

atctggcgca gctgcaagaa aacctggggg gagcctctcg agagcaggcc ctggagattg     1740

caactcacgt cgtgcatatg cttgcgacag aggtacctgg cgccaagcag aggacatacg     1800

ctgcttttaa tccagcagat atggtcatgg taaatttctc tgatatgcct ctctccatgg     1860

ccaacgcatt cgagaaggca gtgaaggcaa aggacgggtt cctgcagcca tcaattcaag     1920

cgtttaatca gtattgggac agagtggcga acggctatgg actgaacgga gccgcagctc     1980

agtttagcct cagcgatgtc gatcccataa ctgcacaggt gaaacagatg cctacgttgg     2040

aacagctgaa gtcatgggta agaaataacg gcgaagccgg cagcggcgag ggcagaggca     2100

gcctgctgac ctgcggcgac gtggaggaga accccggccc ccccaagaaa aagagaaaag     2160

taggatcggg cgattacaaa gatcacgatg gggactacaa ggatcacgat attgactata     2220

aggacgacga tgacaaggga tcgggcatgg ccgacgagat tgacgcaatg gcactttacc     2280

gggcctggca gcagttggat aatggttcat gtgcccagat tcgcagagtt agtgaacctg     2340

acgaactgag agatatcccc gcgttttaca gacttgtcca accgttcgga tgggagaacc     2400

cacggcacca acaagcactc cttcgaatgg tcttctgttt gtccgcagga aaaaatgtaa     2460

tcagacacca agacaaaaag agcgagcaaa ccacaggtat cagcctgggc agggcacttg     2520

ccaactctgg gcggatcaac gaaaggagaa tttttcagct gatacgcgct gatcggactg     2580

cggacatggt gcagctgcgc agactcctta ctcatgccga acctgtcctg gattggcccc     2640

tgatggcacg catgctgact tggtggggaa agagagaaag acagcaactg cttgaagact     2700

tcgtgctcac tacaaataag aatgccggat ccggagaagg aaggggatcc ctcctcacat     2760

gtggagatgt cgaagaaaat cctggacctc ccaagaaaaa gagaaaagta ggatcgggca     2820

tgcggagcta tctcatcctg agactggccg gaccaatgca ggcctgggga cagcctacct     2880

tcgaaggtac acgccccaca ggccgctttc ctaccaggag cggcctgctg ggcctgcttg     2940

gcgcttgtct tgggatccag cgcgatgata ctagctccct gcaagcactg tcagagagcg     3000

tgcagtttgc cgtaagatgc gacgaactga tccttgatga taggcgggtc agtgtcactg     3060

gtctccggga ctaccacacg gtgctggggg cccgggagga ttataggggc ctgaaaagtc     3120

acgagacgat tcaaacctgg cgcgaatatc tgtgcgatgc cagcttcacc gtggccctgt     3180

ggctgactcc acatgccact atggtcatca gtgaactgga aaaggctgtt cttaagcctc     3240

gatatactcc gtatctgggc cgccggagtt gtccacttac acacccactt ttcctcggca     3300

cctgccaggc cagcgaccct caaaaggccc ttctgaatta cgagccagtt ggcggtgaca     3360

tatacagcga agagtccgtg acgggacacc atcttaagtt caccgctcgg gacgagccca     3420

tgattaccct cccacggcag ttcgcatcaa gggagtggta cgtcataaag gggggcatgg     3480

atgtgagtca ggggtctggg gaggggcggg ggtctttgtt gacttgcggg gatgttgagg     3540

agaacccagg gccacccaag aaaaagagaa aagtaggctc aggcggtaaa cccatcccaa     3600

accccttgct tggtctcgac tcaaccggat cgggcatgta tctgtcaaag gttatcattg     3660

cacgcgcgtg gagtagggat ctgtatcagc tgcaccaggg tctgtggcat cttttcccga     3720

accgccccga cgcggcacga gactttctgt ttcacgttga aaaaagaaac acccccgagg     3780

gctgtcatgt gctcctgcag tctgcccaga tgccggtgag cacagctgtg gcgactgtga     3840

tcaagaccaa gcaggtcgag tttcagctcc aggtaggggt tccactgtat tttcgcctga     3900

gagctaatcc gatcaaaacc atactggata atcagaagag gctcgacagc aaaggaaata     3960

ttaaaaggtg ccgggtcccg ctcatcaaag aggctgagca aatcgcttgg cttcaacgga     4020

aactggggaa cgcagcccgc gtggaagacg tccacccgat tagtgaacgg ccccaatatt     4080

tttccggaga cggaaagagc ggcaagattc agacagtctg tttcgagggg gtgctcacca     4140

tcaatgatgc ccccgccctg atagacctgg tgcagcaggg cataggcccc gctaaaagca     4200

tgggatgcgg actgcttagt ctggcaccgc tgggatccgg agagggcaga ggaagtctgc     4260

taacatgcgg tgacgtcgag gagaatcctg gacctcccaa gaaaaagaga aaagtaggat     4320

cgggcatgaa tttgctcatt gataattgga ttccggtgcg cccccggaac ggtgggaaag     4380

tgcagatcat caatttgcaa agtctctact gttccaggga ccagtggaga ctcagcctgc     4440

cacgggatga tatggagctg gcggcgttgg ctctgctcgt atgcatcggc cagattattg     4500

cgccagcaaa ggatgacgtt gaattccggc atcggataat gaaccccctt actgaagatg     4560

agttccagca gcttatcgcc ccatggatcg acatgttcta cctcaaccac gccgagcatc     4620

cttttatgca gaccaaggga gtcaaggcga atgatgtgac tcccatggag aagctgctgg     4680

ccggtgtatc tggggcgacc aactgcgcat tcgtgaatca gcctggacag ggggaggccc     4740

tctgtggagg ctgcactgct atagcacttt ttaaccaagc taatcaagcc cccggctttg     4800

gtggagggtt taagagtgga ttgagggggg gcactcccgt aaccactttt gtgaggggaa     4860

ttgatctgag gtctactgtg ttgctgaacg tcctcacact cccaaggctc cagaagcagt     4920

tcccaaacga aagtcatacc gaaaaccagc ccacatggat caagcccatc aaatctaatg     4980

agagcatacc ggctagcagt attggatttg tacggggtct gttctggcag ccagctcaca     5040

tcgagctgtg tgatcctatt gggatcggca agtgctcttg ttgtgggcag gagtccaacc     5100

ttaggtatac tggatttctg aaagagaagt ttacctttac agtaaatggg ctctggcccc     5160

acccccactc accttgcctt gtgacagtga aaaaggggga agtcgaggag aagtttctgg     5220

cctttacaac ttctgcccct tcctggactc agatttccag agtggtggta gataagataa     5280

ttcaaaacga gaatggcaat agagtggccg ccgtggtgaa ccagtttcgc aacatcgccc     5340

ctcagtcccc cctggagctg attatgggcg gttatcggaa taaccaggcc agtatactcg     5400

agcgacggca cgatgtcctc atgttcaatc aaggttggca gcaatatggc aatgtgatta     5460

acgagatcgt aaccgtgggc ctgggatata agaccgccct gcggaaggcg ttgtatactt     5520

ttgcagaagg ctttaagaat aaggatttta agggtgccgg cgtgagtgtc catgaaacag     5580

ctgaacggca cttttatcgg cagtccgagc tgttgatacc agacgtgctg gctaatgtga     5640

acttctcaca ggccgacgaa gtgatcgctg atctgcggga taaactgcac caactgtgcg     5700

agatgctgtt taatcaaagc gtcgctcctt atgcccacca cccaaagctg atctccacgc     5760

tggccctggc gcgcgccaca ctttataaac atctccgcga actgaaaccc caggggggcc     5820

ccagcaatgg ctaataatct agagggccct attctatagt gtcacctaaa tgctagagct     5880

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     5940

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     6000

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     6060

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     6120

gcttctgagg cggaaagaac cagctggggc tctagggggt atccccacgc gccctgtagc     6180

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     6240

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     6300

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     6360

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag     6420

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     6480

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg     6540

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattaattc     6600

tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta     6660

tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag     6720

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa     6780

ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc catggctgac     6840

taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta ttccagaagt     6900

agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga gcttgtatat     6960

ccattttcgg atctgatcaa gagacaggat gaggatcgtt tcgcatgatt gaacaagatg     7020

gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac     7080

aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg     7140

ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac gaggcagcgc     7200

ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg     7260

aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc     7320

accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc     7380

ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta     7440

ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg     7500

cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag gatctcgtcg     7560

tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat     7620

tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc     7680

gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta     7740

tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgag     7800

cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat cacgagattt     7860

cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc gggacgccgg     7920

ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc ccaacttgtt     7980

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     8040

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     8100

ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc tgtttcctgt     8160

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     8220

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     8280

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     8340

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     8400

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     8460

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     8520

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     8580

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     8640

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     8700

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     8760

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     8820

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     8880

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     8940

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     9000

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     9060

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     9120

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     9180

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     9240

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     9300

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     9360

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     9420

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     9480

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     9540

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     9600

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     9660

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     9720

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     9780

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     9840

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     9900

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     9960

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag    10020

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac    10080

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc    10140

gacacggaaa tgttgaatac tcatactctt cctttttcat tattattgaa gcatttatca    10200

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg    10260

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc                          10300


<210>  382
<211>  10978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polycistronic(HsCO), 
       NLSCas7_NLSCse2_NLSCas5_NLSCas6_NLSFokI30aaCas8

<400>  382
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc gaacagaaac      960

ttatatctga ggaggacctc ggatcgggca tgtcaaattt tattaatatt catgttctga     1020

tcagtcatag cccgagttgc ctgaatagag acgacatgaa tatgcagaaa gacgcaattt     1080

tcggtggcaa gaggcgagtc cgaataagca gccaaagtct taagcgagcc atgaggaaga     1140

gcggctatta tgcccagaat atcggcgagt cctcattgcg gaccatccac ctcgcccagt     1200

tgagagacgt cttgaggcag aaactggggg aaagattcga ccagaaaatc attgacaaga     1260

cccttgccct ccttagtggg aagagcgtgg acgaggctga aaaaatctct gccgacgccg     1320

taacgccctg ggttgtgggt gagattgctt ggttttgtga acaggtggcg aaggcggagg     1380

ccgataacct ggatgacaag aagctgctga aggtccttaa ggaggacata gctgccattc     1440

gggtcaattt gcagcaggga gtggatatcg cattgtccgg aagaatggct acatcaggca     1500

tgatgaccga gctgggcaag gtagacggag ccatgagtat cgcacacgcc atcaccaccc     1560

accaagtcga ctcagacatc gactggttca cagcagtaga tgacctccag gagcaggggt     1620

ctgcccacct tgggacacag gagttctctt ccggggtgtt ttatcgctat gctaatatca     1680

atctggcgca gctgcaagaa aacctggggg gagcctctcg agagcaggcc ctggagattg     1740

caactcacgt cgtgcatatg cttgcgacag aggtacctgg cgccaagcag aggacatacg     1800

ctgcttttaa tccagcagat atggtcatgg taaatttctc tgatatgcct ctctccatgg     1860

ccaacgcatt cgagaaggca gtgaaggcaa aggacgggtt cctgcagcca tcaattcaag     1920

cgtttaatca gtattgggac agagtggcga acggctatgg actgaacgga gccgcagctc     1980

agtttagcct cagcgatgtc gatcccataa ctgcacaggt gaaacagatg cctacgttgg     2040

aacagctgaa gtcatgggta agaaataacg gcgaagccgg cagcggcgag ggcagaggca     2100

gcctgctgac ctgcggcgac gtggaggaga accccggccc ccccaagaaa aagagaaaag     2160

taggatcggg cgattacaaa gatcacgatg gggactacaa ggatcacgat attgactata     2220

aggacgacga tgacaaggga tcgggcatgg ccgacgagat tgacgcaatg gcactttacc     2280

gggcctggca gcagttggat aatggttcat gtgcccagat tcgcagagtt agtgaacctg     2340

acgaactgag agatatcccc gcgttttaca gacttgtcca accgttcgga tgggagaacc     2400

cacggcacca acaagcactc cttcgaatgg tcttctgttt gtccgcagga aaaaatgtaa     2460

tcagacacca agacaaaaag agcgagcaaa ccacaggtat cagcctgggc agggcacttg     2520

ccaactctgg gcggatcaac gaaaggagaa tttttcagct gatacgcgct gatcggactg     2580

cggacatggt gcagctgcgc agactcctta ctcatgccga acctgtcctg gattggcccc     2640

tgatggcacg catgctgact tggtggggaa agagagaaag acagcaactg cttgaagact     2700

tcgtgctcac tacaaataag aatgccggat ccggagaagg aaggggatcc ctcctcacat     2760

gtggagatgt cgaagaaaat cctggacctc ccaagaaaaa gagaaaagta ggatcgggca     2820

tgcggagcta tctcatcctg agactggccg gaccaatgca ggcctgggga cagcctacct     2880

tcgaaggtac acgccccaca ggccgctttc ctaccaggag cggcctgctg ggcctgcttg     2940

gcgcttgtct tgggatccag cgcgatgata ctagctccct gcaagcactg tcagagagcg     3000

tgcagtttgc cgtaagatgc gacgaactga tccttgatga taggcgggtc agtgtcactg     3060

gtctccggga ctaccacacg gtgctggggg cccgggagga ttataggggc ctgaaaagtc     3120

acgagacgat tcaaacctgg cgcgaatatc tgtgcgatgc cagcttcacc gtggccctgt     3180

ggctgactcc acatgccact atggtcatca gtgaactgga aaaggctgtt cttaagcctc     3240

gatatactcc gtatctgggc cgccggagtt gtccacttac acacccactt ttcctcggca     3300

cctgccaggc cagcgaccct caaaaggccc ttctgaatta cgagccagtt ggcggtgaca     3360

tatacagcga agagtccgtg acgggacacc atcttaagtt caccgctcgg gacgagccca     3420

tgattaccct cccacggcag ttcgcatcaa gggagtggta cgtcataaag gggggcatgg     3480

atgtgagtca ggggtctggg gaggggcggg ggtctttgtt gacttgcggg gatgttgagg     3540

agaacccagg gccacccaag aaaaagagaa aagtaggctc aggcggtaaa cccatcccaa     3600

accccttgct tggtctcgac tcaaccggat cgggcatgta tctgtcaaag gttatcattg     3660

cacgcgcgtg gagtagggat ctgtatcagc tgcaccaggg tctgtggcat cttttcccga     3720

accgccccga cgcggcacga gactttctgt ttcacgttga aaaaagaaac acccccgagg     3780

gctgtcatgt gctcctgcag tctgcccaga tgccggtgag cacagctgtg gcgactgtga     3840

tcaagaccaa gcaggtcgag tttcagctcc aggtaggggt tccactgtat tttcgcctga     3900

gagctaatcc gatcaaaacc atactggata atcagaagag gctcgacagc aaaggaaata     3960

ttaaaaggtg ccgggtcccg ctcatcaaag aggctgagca aatcgcttgg cttcaacgga     4020

aactggggaa cgcagcccgc gtggaagacg tccacccgat tagtgaacgg ccccaatatt     4080

tttccggaga cggaaagagc ggcaagattc agacagtctg tttcgagggg gtgctcacca     4140

tcaatgatgc ccccgccctg atagacctgg tgcagcaggg cataggcccc gctaaaagca     4200

tgggatgcgg actgcttagt ctggcaccgc tgggatccgg agagggcaga ggaagtctgc     4260

taacatgcgg tgacgtcgag gagaatcctg gacctcccaa gaaaaagaga aaagtaggcg     4320

gctcacaatt ggtcaaaagc gaactggaag agaaaaaatc tgagctcaga cacaagctga     4380

agtatgtgcc ccatgaatac atagaactca tagaaatagc tcgaaacccc acgcaggacc     4440

ggatccttga aatgaaagtt atggagtttt ttatgaaagt gtatgggtat cgaggagagc     4500

atcttggtgg aagtcggaaa ccggatgggg caatatacac tgttgggagc cccattgact     4560

atggtgtgat agtggacacc aaggcataca gcgggggata caatctgccg atcgggcagg     4620

cagatgagat gcagcgctat gtggaggaga atcaaactag gaacaaacat attaacccaa     4680

acgaatggtg gaaagtgtat ccctcatctg ttacggagtt caagttcctt tttgtatctg     4740

gccactttaa aggaaactat aaagcacagc tcacgcgact taaccacatc accaattgta     4800

acggtgctgt actcagtgtt gaggaactcc tgatcggtgg tgaaatgata aaagctggaa     4860

ccttgacatt ggaggaagta aggagaaagt ttaataatgg tgagatcaat ttcagcggct     4920

ccgaaacgcc gggtacatcc gagtccgcga ctcctgagtc aggaggcagc ggctcctctg     4980

gtggaagcgg ctcaagtgga gggatgaatt tgctcattga taattggatt ccggtgcgcc     5040

cccggaacgg tgggaaagtg cagatcatca atttgcaaag tctctactgt tccagggacc     5100

agtggagact cagcctgcca cgggatgata tggagctggc ggcgttggct ctgctcgtat     5160

gcatcggcca gattattgcg ccagcaaagg atgacgttga attccggcat cggataatga     5220

acccccttac tgaagatgag ttccagcagc ttatcgcccc atggatcgac atgttctacc     5280

tcaaccacgc cgagcatcct tttatgcaga ccaagggagt caaggcgaat gatgtgactc     5340

ccatggagaa gctgctggcc ggtgtatctg gggcgaccaa ctgcgcattc gtgaatcagc     5400

ctggacaggg ggaggccctc tgtggaggct gcactgctat agcacttttt aaccaagcta     5460

atcaagcccc cggctttggt ggagggttta agagtggatt gagggggggc actcccgtaa     5520

ccacttttgt gaggggaatt gatctgaggt ctactgtgtt gctgaacgtc ctcacactcc     5580

caaggctcca gaagcagttc ccaaacgaaa gtcataccga aaaccagccc acatggatca     5640

agcccatcaa atctaatgag agcataccgg ctagcagtat tggatttgta cggggtctgt     5700

tctggcagcc agctcacatc gagctgtgtg atcctattgg gatcggcaag tgctcttgtt     5760

gtgggcagga gtccaacctt aggtatactg gatttctgaa agagaagttt acctttacag     5820

taaatgggct ctggccccac ccccactcac cttgccttgt gacagtgaaa aagggggaag     5880

tcgaggagaa gtttctggcc tttacaactt ctgccccttc ctggactcag atttccagag     5940

tggtggtaga taagataatt caaaacgaga atggcaatag agtggccgcc gtggtgaacc     6000

agtttcgcaa catcgcccct cagtcccccc tggagctgat tatgggcggt tatcggaata     6060

accaggccag tatactcgag cgacggcacg atgtcctcat gttcaatcaa ggttggcagc     6120

aatatggcaa tgtgattaac gagatcgtaa ccgtgggcct gggatataag accgccctgc     6180

ggaaggcgtt gtatactttt gcagaaggct ttaagaataa ggattttaag ggtgccggcg     6240

tgagtgtcca tgaaacagct gaacggcact tttatcggca gtccgagctg ttgataccag     6300

acgtgctggc taatgtgaac ttctcacagg ccgacgaagt gatcgctgat ctgcgggata     6360

aactgcacca actgtgcgag atgctgttta atcaaagcgt cgctccttat gcccaccacc     6420

caaagctgat ctccacgctg gccctggcgc gcgccacact ttataaacat ctccgcgaac     6480

tgaaacccca ggggggcccc agcaatggct aataatctag agggccctat tctatagtgt     6540

cacctaaatg ctagagctcg ctgatcagcc tcgactgtgc cttctagttg ccagccatct     6600

gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt     6660

tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg     6720

ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg     6780

gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc tagggggtat     6840

ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg     6900

accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc     6960

gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga     7020

tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt     7080

gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat     7140

agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat     7200

ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa     7260

tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct     7320

ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa     7380

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     7440

ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt     7500

ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct     7560

ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc     7620

tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga ggatcgtttc     7680

gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat     7740

tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt     7800

cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac     7860

tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg     7920

tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc     7980

aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa     8040

tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc     8100

gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg     8160

aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg     8220

acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa     8280

atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg     8340

acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct     8400

tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc     8460

ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag cgacgcccaa     8520

cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg gcttcggaat     8580

cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc tggagttctt     8640

cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     8700

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     8760

caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg cgtaatcatg     8820

gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc     8880

cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc     8940

gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat     9000

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     9060

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     9120

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     9180

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     9240

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     9300

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     9360

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     9420

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     9480

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     9540

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     9600

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     9660

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     9720

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     9780

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     9840

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     9900

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     9960

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat    10020

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg    10080

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc    10140

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc    10200

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc    10260

gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc    10320

gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc    10380

ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa    10440

gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat    10500

gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata    10560

gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca    10620

tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag    10680

gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc    10740

agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc    10800

aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcatta    10860

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta    10920

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtc      10978


<210>  383
<211>  10813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polycistronic(HsCO), 
       NLSCas7_NLSCse2_NLSCas5_NLSCas6_NLSFokI30aaCas8, no epitope tags

<400>  383
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcagggg tctggggagg ggcgggggtc tttgttgact tgcggggatg     3420

ttgaggagaa tcctggacct cccaaaaaaa aacggaaggt gggctcaggc atgtatctgt     3480

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     3540

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     3600

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     3660

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     3720

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     3780

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     3840

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     3900

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     3960

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     4020

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctggga tccggagagg     4080

gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggacct cccaagaaaa     4140

agagaaaagt aggcggctca caattggtca aaagcgaact ggaagagaaa aaatctgagc     4200

tcagacacaa gctgaagtat gtgccccatg aatacataga actcatagaa atagctcgaa     4260

accccacgca ggaccggatc cttgaaatga aagttatgga gttttttatg aaagtgtatg     4320

ggtatcgagg agagcatctt ggtggaagtc ggaaaccgga tggggcaata tacactgttg     4380

ggagccccat tgactatggt gtgatagtgg acaccaaggc atacagcggg ggatacaatc     4440

tgccgatcgg gcaggcagat gagatgcagc gctatgtgga ggagaatcaa actaggaaca     4500

aacatattaa cccaaacgaa tggtggaaag tgtatccctc atctgttacg gagttcaagt     4560

tcctttttgt atctggccac tttaaaggaa actataaagc acagctcacg cgacttaacc     4620

acatcaccaa ttgtaacggt gctgtactca gtgttgagga actcctgatc ggtggtgaaa     4680

tgataaaagc tggaaccttg acattggagg aagtaaggag aaagtttaat aatggtgaga     4740

tcaatttcag cggctccgaa acgccgggta catccgagtc cgcgactcct gagtcaggag     4800

gcagcggctc ctctggtgga agcggctcaa gtggagggat gaatttgctc attgataatt     4860

ggattccggt gcgcccccgg aacggtggga aagtgcagat catcaatttg caaagtctct     4920

actgttccag ggaccagtgg agactcagcc tgccacggga tgatatggag ctggcggcgt     4980

tggctctgct cgtatgcatc ggccagatta ttgcgccagc aaaggatgac gttgaattcc     5040

ggcatcggat aatgaacccc cttactgaag atgagttcca gcagcttatc gccccatgga     5100

tcgacatgtt ctacctcaac cacgccgagc atccttttat gcagaccaag ggagtcaagg     5160

cgaatgatgt gactcccatg gagaagctgc tggccggtgt atctggggcg accaactgcg     5220

cattcgtgaa tcagcctgga cagggggagg ccctctgtgg aggctgcact gctatagcac     5280

tttttaacca agctaatcaa gcccccggct ttggtggagg gtttaagagt ggattgaggg     5340

ggggcactcc cgtaaccact tttgtgaggg gaattgatct gaggtctact gtgttgctga     5400

acgtcctcac actcccaagg ctccagaagc agttcccaaa cgaaagtcat accgaaaacc     5460

agcccacatg gatcaagccc atcaaatcta atgagagcat accggctagc agtattggat     5520

ttgtacgggg tctgttctgg cagccagctc acatcgagct gtgtgatcct attgggatcg     5580

gcaagtgctc ttgttgtggg caggagtcca accttaggta tactggattt ctgaaagaga     5640

agtttacctt tacagtaaat gggctctggc cccaccccca ctcaccttgc cttgtgacag     5700

tgaaaaaggg ggaagtcgag gagaagtttc tggcctttac aacttctgcc ccttcctgga     5760

ctcagatttc cagagtggtg gtagataaga taattcaaaa cgagaatggc aatagagtgg     5820

ccgccgtggt gaaccagttt cgcaacatcg cccctcagtc ccccctggag ctgattatgg     5880

gcggttatcg gaataaccag gccagtatac tcgagcgacg gcacgatgtc ctcatgttca     5940

atcaaggttg gcagcaatat ggcaatgtga ttaacgagat cgtaaccgtg ggcctgggat     6000

ataagaccgc cctgcggaag gcgttgtata cttttgcaga aggctttaag aataaggatt     6060

ttaagggtgc cggcgtgagt gtccatgaaa cagctgaacg gcacttttat cggcagtccg     6120

agctgttgat accagacgtg ctggctaatg tgaacttctc acaggccgac gaagtgatcg     6180

ctgatctgcg ggataaactg caccaactgt gcgagatgct gtttaatcaa agcgtcgctc     6240

cttatgccca ccacccaaag ctgatctcca cgctggccct ggcgcgcgcc acactttata     6300

aacatctccg cgaactgaaa ccccaggggg gccccagcaa tggctaataa tctagagggc     6360

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     6420

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     6480

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     6540

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     6600

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     6660

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     6720

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     6780

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     6840

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     6900

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     6960

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     7020

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag     7080

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     7140

gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag     7200

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     7260

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc     7320

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     7380

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     7440

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag     7500

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt     7560

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg     7620

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg     7680

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg     7740

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg     7800

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca     7860

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc     7920

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc     7980

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca     8040

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga     8100

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg     8160

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg     8220

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg     8280

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga     8340

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag     8400

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct     8460

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata     8520

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg     8580

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag     8640

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc     8700

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta     8760

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca     8820

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     8880

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     8940

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     9000

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     9060

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     9120

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     9180

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     9240

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     9300

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     9360

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     9420

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     9480

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     9540

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     9600

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     9660

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     9720

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     9780

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     9840

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     9900

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     9960

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    10020

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    10080

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    10140

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    10200

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    10260

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    10320

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    10380

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    10440

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    10500

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    10560

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    10620

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    10680

cttccttttt cattattatt gaagcattta tcagggttat tgtctcatga gcggatacat    10740

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    10800

gccacctgac gtc                                                       10813


<210>  384
<211>  10813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Polycistronic(HsCO), 
       NLSCas7_NLSCse2_NLSCas5_NLSFokI30aaCas6_NLSCas8, no epitope tags

<400>  384
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcagggg tctggggagg ggcgggggtc tttgttgact tgcggggatg     3420

ttgaggagaa tcctggacct cccaaaaaaa aacggaaggt gggctcaggc caattggtca     3480

aaagcgaact ggaagagaaa aaatctgagc tcagacacaa gctgaagtat gtgccccatg     3540

aatacataga actcatagaa atagctcgaa accccacgca ggaccggatc cttgaaatga     3600

aagttatgga gttttttatg aaagtgtatg ggtatcgagg agagcatctt ggtggaagtc     3660

ggaaaccgga tggggcaata tacactgttg ggagccccat tgactatggt gtgatagtgg     3720

acaccaaggc atacagcggg ggatacaatc tgccgatcgg gcaggcagat gagatgcagc     3780

gctatgtgga ggagaatcaa actaggaaca aacatattaa cccaaacgaa tggtggaaag     3840

tgtatccctc atctgttacg gagttcaagt tcctttttgt atctggccac tttaaaggaa     3900

actataaagc acagctcacg cgacttaacc acatcaccaa ttgtaacggt gctgtactca     3960

gtgttgagga actcctgatc ggtggtgaaa tgataaaagc tggaaccttg acattggagg     4020

aagtaaggag aaagtttaat aatggtgaga tcaatttcag cggctccgaa acgccgggta     4080

catccgagtc cgcgactcct gagtcaggag gcagcggctc ctctggtgga agcggctcaa     4140

gtggagggat gtatctgtca aaggttatca ttgcacgcgc gtggagtagg gatctgtatc     4200

agctgcacca gggtctgtgg catcttttcc cgaaccgccc cgacgcggca cgagactttc     4260

tgtttcacgt tgaaaaaaga aacacccccg agggctgtca tgtgctcctg cagtctgccc     4320

agatgccggt gagcacagct gtggcgactg tgatcaagac caagcaggtc gagtttcagc     4380

tccaggtagg ggttccactg tattttcgcc tgagagctaa tccgatcaaa accatactgg     4440

ataatcagaa gaggctcgac agcaaaggaa atattaaaag gtgccgggtc ccgctcatca     4500

aagaggctga gcaaatcgct tggcttcaac ggaaactggg gaacgcagcc cgcgtggaag     4560

acgtccaccc gattagtgaa cggccccaat atttttccgg agacggaaag agcggcaaga     4620

ttcagacagt ctgtttcgag ggggtgctca ccatcaatga tgcccccgcc ctgatagacc     4680

tggtgcagca gggcataggc cccgctaaaa gcatgggatg cggactgctt agtctggcac     4740

cgctgggatc cggagagggc agaggaagtc tgctaacatg cggtgacgtc gaggagaatc     4800

ctggacctcc caagaaaaag agaaaagtag gatcgggcat gaatttgctc attgataatt     4860

ggattccggt gcgcccccgg aacggtggga aagtgcagat catcaatttg caaagtctct     4920

actgttccag ggaccagtgg agactcagcc tgccacggga tgatatggag ctggcggcgt     4980

tggctctgct cgtatgcatc ggccagatta ttgcgccagc aaaggatgac gttgaattcc     5040

ggcatcggat aatgaacccc cttactgaag atgagttcca gcagcttatc gccccatgga     5100

tcgacatgtt ctacctcaac cacgccgagc atccttttat gcagaccaag ggagtcaagg     5160

cgaatgatgt gactcccatg gagaagctgc tggccggtgt atctggggcg accaactgcg     5220

cattcgtgaa tcagcctgga cagggggagg ccctctgtgg aggctgcact gctatagcac     5280

tttttaacca agctaatcaa gcccccggct ttggtggagg gtttaagagt ggattgaggg     5340

ggggcactcc cgtaaccact tttgtgaggg gaattgatct gaggtctact gtgttgctga     5400

acgtcctcac actcccaagg ctccagaagc agttcccaaa cgaaagtcat accgaaaacc     5460

agcccacatg gatcaagccc atcaaatcta atgagagcat accggctagc agtattggat     5520

ttgtacgggg tctgttctgg cagccagctc acatcgagct gtgtgatcct attgggatcg     5580

gcaagtgctc ttgttgtggg caggagtcca accttaggta tactggattt ctgaaagaga     5640

agtttacctt tacagtaaat gggctctggc cccaccccca ctcaccttgc cttgtgacag     5700

tgaaaaaggg ggaagtcgag gagaagtttc tggcctttac aacttctgcc ccttcctgga     5760

ctcagatttc cagagtggtg gtagataaga taattcaaaa cgagaatggc aatagagtgg     5820

ccgccgtggt gaaccagttt cgcaacatcg cccctcagtc ccccctggag ctgattatgg     5880

gcggttatcg gaataaccag gccagtatac tcgagcgacg gcacgatgtc ctcatgttca     5940

atcaaggttg gcagcaatat ggcaatgtga ttaacgagat cgtaaccgtg ggcctgggat     6000

ataagaccgc cctgcggaag gcgttgtata cttttgcaga aggctttaag aataaggatt     6060

ttaagggtgc cggcgtgagt gtccatgaaa cagctgaacg gcacttttat cggcagtccg     6120

agctgttgat accagacgtg ctggctaatg tgaacttctc acaggccgac gaagtgatcg     6180

ctgatctgcg ggataaactg caccaactgt gcgagatgct gtttaatcaa agcgtcgctc     6240

cttatgccca ccacccaaag ctgatctcca cgctggccct ggcgcgcgcc acactttata     6300

aacatctccg cgaactgaaa ccccaggggg gccccagcaa tggctaataa tctagagggc     6360

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     6420

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     6480

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     6540

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     6600

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     6660

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     6720

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     6780

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     6840

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     6900

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     6960

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     7020

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag     7080

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     7140

gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag     7200

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     7260

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc     7320

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     7380

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     7440

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag     7500

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt     7560

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg     7620

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg     7680

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg     7740

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg     7800

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca     7860

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc     7920

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc     7980

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca     8040

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga     8100

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg     8160

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg     8220

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg     8280

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga     8340

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag     8400

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct     8460

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata     8520

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg     8580

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag     8640

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc     8700

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta     8760

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca     8820

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     8880

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     8940

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     9000

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     9060

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     9120

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     9180

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     9240

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     9300

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     9360

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     9420

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     9480

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     9540

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     9600

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     9660

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     9720

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     9780

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     9840

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     9900

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     9960

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    10020

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    10080

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    10140

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    10200

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    10260

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    10320

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    10380

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    10440

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    10500

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    10560

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    10620

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    10680

cttccttttt cattattatt gaagcattta tcagggttat tgtctcatga gcggatacat    10740

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    10800

gccacctgac gtc                                                       10813


<210>  385
<211>  6475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: eGFP_MALAT1-triplex_CRISPR(Hsa07)

<400>  385
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgggc tccgggattg gtagtgggag      960

caacggcagc agcggatccg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat     1020

cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgcgcg gcgagggcga     1080

gggcgatgcc accaacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc     1140

cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta     1200

ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca     1260

ggagcgcacc atctccttca aggacgacgg cacctacaag acccgcgccg aggtgaagtt     1320

cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg     1380

caacatcctg gggcacaagc tggagtacaa cttcaacagc cacaacgtct atatcacggc     1440

cgacaagcag aagaacggca tcaaggcgaa cttcaagatc cgccacaacg tcgaggacgg     1500

cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct     1560

gctgcccgac aaccactacc tgagcaccca gtccaagctg agcaaagacc ccaacgagaa     1620

gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga     1680

cgagctgtac aagtagtaat ctagagattc gtcagtaggg ttgtaaaggt ttttcttttc     1740

ctgagaaaac aaccttttgt tttctcaggt tttgcttttt ggcctttccc tagctttaaa     1800

aaaaaaaaag caaaactcac cgaggcagtt ataccatggg ctagcgagtt ccccgcgcca     1860

gcggggataa accggttgat ttgcctgcat tggtgttaca cagtctgagt tccccgcgcc     1920

agcggggata aaccgtaagt tgtgttcttc tttgcctagg ccttcaggag ttccccgcgc     1980

cagcggggat aaaccggagc tcgctgagca atctagaggg ccctattcta tagtgtcacc     2040

taaatgctag agctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg     2100

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     2160

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg     2220

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     2280

cggtgggctc tatggcttct gaggcggaaa gaaccagctg gggctctagg gggtatcccc     2340

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     2400

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     2460

cgttcgccgg ctttccccgt caagctctaa atcggggcat ccctttaggg ttccgattta     2520

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     2580

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     2640

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     2700

aagggatttt ggggatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     2760

acgcgaatta attctgtgga atgtgtgtca gttagggtgt ggaaagtccc caggctcccc     2820

aggcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg tgtggaaagt     2880

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     2940

tagtcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc     3000

cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc tctgcctctg     3060

agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc aaaaagctcc     3120

cgggagcttg tatatccatt ttcggatctg atcaagagac aggatgagga tcgtttcgca     3180

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg     3240

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag     3300

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc     3360

aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc     3420

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg     3480

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc     3540

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca     3600

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag     3660

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc atgcccgacg     3720

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg     3780

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca     3840

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc     3900

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg     3960

acgagttctt ctgagcggga ctctggggtt cgaaatgacc gaccaagcga cgcccaacct     4020

gccatcacga gatttcgatt ccaccgccgc cttctatgaa aggttgggct tcggaatcgt     4080

tttccgggac gccggctgga tgatcctcca gcgcggggat ctcatgctgg agttcttcgc     4140

ccaccccaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa     4200

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa     4260

tgtatcttat catgtctgta taccgtcgac ctctagctag agcttggcgt aatcatggtc     4320

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     4380

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     4440

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     4500

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     4560

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     4620

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     4680

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     4740

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     4800

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     4860

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc     4920

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     4980

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     5040

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     5100

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     5160

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     5220

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     5280

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     5340

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     5400

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     5460

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     5520

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     5580

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     5640

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     5700

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     5760

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc     5820

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     5880

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     5940

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     6000

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     6060

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag     6120

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     6180

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     6240

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     6300

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcattatta     6360

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     6420

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtc          6475


<210>  386
<211>  6854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas7_MALAT1-triplex_CRISPR(Hsa07)

<400>  386
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatgccg aaaaaaaagc ggaaggtcgg      960

atcaggaatg tcaaatttta ttaatattca tgttctgatc agtcatagcc cgagttgcct     1020

gaatagagac gacatgaata tgcagaaaga cgcaattttc ggtggcaaga ggcgagtccg     1080

aataagcagc caaagtctta agcgagccat gaggaagagc ggctattatg cccagaatat     1140

cggcgagtcc tcattgcgga ccatccacct cgcccagttg agagacgtct tgaggcagaa     1200

actgggggaa agattcgacc agaaaatcat tgacaagacc cttgccctcc ttagtgggaa     1260

gagcgtggac gaggctgaaa aaatctctgc cgacgccgta acgccctggg ttgtgggtga     1320

gattgcttgg ttttgtgaac aggtggcgaa ggcggaggcc gataacctgg atgacaagaa     1380

gctgctgaag gtccttaagg aggacatagc tgccattcgg gtcaatttgc agcagggagt     1440

ggatatcgca ttgtccggaa gaatggctac atcaggcatg atgaccgagc tgggcaaggt     1500

agacggagcc atgagtatcg cacacgccat caccacccac caagtcgact cagacatcga     1560

ctggttcaca gcagtagatg acctccagga gcaggggtct gcccaccttg ggacacagga     1620

gttctcttcc ggggtgtttt atcgctatgc taatatcaat ctggcgcagc tgcaagaaaa     1680

cctgggggga gcctctcgag agcaggccct ggagattgca actcacgtcg tgcatatgct     1740

tgcgacagag gtacctggcg ccaagcagag gacatacgct gcttttaatc cagcagatat     1800

ggtcatggta aatttctctg atatgcctct ctccatggcc aacgcattcg agaaggcagt     1860

gaaggcaaag gacgggttcc tgcagccatc aattcaagcg tttaatcagt attgggacag     1920

agtggcgaac ggctatggac tgaacggagc cgcagctcag tttagcctca gcgatgtcga     1980

tcccataact gcacaggtga aacagatgcc tacgttggaa cagctgaagt catgggtaag     2040

aaataacggc gaagcctaat aacattggaa gtggataatc tagagattcg tcagtagggt     2100

tgtaaaggtt tttcttttcc tgagaaaaca accttttgtt ttctcaggtt ttgctttttg     2160

gcctttccct agctttaaaa aaaaaaaagc aaaactcacc gaggcagtta taccatgggc     2220

tagcgagttc cccgcgccag cggggataaa ccggttgatt tgcctgcatt ggtgttacac     2280

agtctgagtt ccccgcgcca gcggggataa accgtaagtt gtgttcttct ttgcctaggc     2340

cttcaggagt tccccgcgcc agcggggata aaccggagct cgctgagcaa tctagagggc     2400

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     2460

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     2520

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     2580

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     2640

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     2700

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     2760

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     2820

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     2880

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     2940

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     3000

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     3060

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     3120

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     3180

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     3240

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     3300

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     3360

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     3420

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     3480

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     3540

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     3600

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     3660

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     3720

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     3780

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     3840

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     3900

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     3960

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     4020

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     4080

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     4140

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     4200

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     4260

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     4320

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     4380

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     4440

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     4500

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     4560

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     4620

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     4680

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     4740

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     4800

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     4860

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     4920

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     4980

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     5040

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     5100

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     5160

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     5220

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     5280

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     5340

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     5400

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     5460

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     5520

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     5580

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     5640

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5700

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5760

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5820

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5880

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5940

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     6000

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     6060

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     6120

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     6180

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     6240

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     6300

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     6360

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     6420

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     6480

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     6540

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6600

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6660

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6720

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6780

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6840

tgccacctga cgtc                                                       6854


<210>  387
<211>  6328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas6_MALAT1-triplex_CRISPR(Hsa07)

<400>  387
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc atgtatctgt      960

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     1020

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     1080

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     1140

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     1200

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     1260

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     1320

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     1380

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     1440

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     1500

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctgtaa taatctagag     1560

attcgtcagt agggttgtaa aggtttttct tttcctgaga aaacaacctt ttgttttctc     1620

aggttttgct ttttggcctt tccctagctt taaaaaaaaa aaagcaaaac tcaccgaggc     1680

agttatacca tgggctagcg agttccccgc gccagcgggg ataaaccggt tgatttgcct     1740

gcattggtgt tacacagtct gagttccccg cgccagcggg gataaaccgt aagttgtgtt     1800

cttctttgcc taggccttca ggagttcccc gcgccagcgg ggataaaccg gagctcgctg     1860

agcaatctag agggccctat tctatagtgt cacctaaatg ctagagctcg ctgatcagcc     1920

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     1980

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     2040

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     2100

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     2160

gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc     2220

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     2280

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     2340

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     2400

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     2460

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     2520

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     2580

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt     2640

gtcagttagg gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc     2700

atctcaatta gtcagcaacc aggtgtggaa agtccccagg ctccccagca ggcagaagta     2760

tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc gcccctaact ccgcccatcc     2820

cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta     2880

tttatgcaga ggccgaggcc gcctctgcct ctgagctatt ccagaagtag tgaggaggct     2940

tttttggagg cctaggcttt tgcaaaaagc tcccgggagc ttgtatatcc attttcggat     3000

ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag     3060

gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg     3120

gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca     3180

agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc     3240

tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg     3300

actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg     3360

ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta     3420

cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag     3480

ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac     3540

tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg acccatggcg     3600

atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg     3660

gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg     3720

aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg     3780

attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg ggactctggg     3840

gttcgaaatg accgaccaag cgacgcccaa cctgccatca cgagatttcg attccaccgc     3900

cgccttctat gaaaggttgg gcttcggaat cgttttccgg gacgccggct ggatgatcct     3960

ccagcgcggg gatctcatgc tggagttctt cgcccacccc aacttgttta ttgcagctta     4020

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact     4080

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct gtataccgtc     4140

gacctctagc tagagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta     4200

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc     4260

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg     4320

aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg     4380

tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg     4440

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa     4500

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     4560

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     4620

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     4680

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     4740

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     4800

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     4860

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     4920

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     4980

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     5040

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     5100

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     5160

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     5220

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     5280

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     5340

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     5400

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     5460

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     5520

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     5580

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     5640

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     5700

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     5760

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     5820

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     5880

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     5940

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     6000

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     6060

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     6120

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     6180

ttgaatactc atactcttcc tttttcatta ttattgaagc atttatcagg gttattgtct     6240

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac     6300

atttccccga aaagtgccac ctgacgtc                                        6328


<210>  388
<211>  11541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hU6_CRISPR(Hsa07)_F, 
       CMV_NLSCas7_NLSCse2_NLSCas5_NLSCas6_NLSFokI30aaCas8

<400>  388
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgtgagggcc      240

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg      300

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      360

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      420

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      480

ccggatccta atacgactca ctatagggta aggagatata ccatgggcta gcgagttccc      540

cgcgccagcg gggataaacc ggttgatttg cctgcattgg tgttacacag tctgagttcc      600

ccgcgccagc ggggataaac cgtaagttgt gttcttcttt gcctaggcct tcaggagttc      660

cccgcgccag cggggataaa ccggagctcg ctgagcaata actctgaaac ctcaggcatt      720

tgagaagtct agattttttt cggaaagaac cagctggggc tctagggggt atccccacgc      780

gccctgtagc acgcgttgac attgattatt gactagttat taatagtaat caattacggg      840

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      900

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      960

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc     1020

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga     1080

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg     1140

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat     1200

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt     1260

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc     1320

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc     1380

tctctggcta actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta     1440

tagggagacc caagcttggt accgagctcg gatcgccacc atgcccaaga aaaagagaaa     1500

agtaggatcg ggcgaacaga aacttatatc tgaggaggac ctcggatcgg gcatgtcaaa     1560

ttttattaat attcatgttc tgatcagtca tagcccgagt tgcctgaata gagacgacat     1620

gaatatgcag aaagacgcaa ttttcggtgg caagaggcga gtccgaataa gcagccaaag     1680

tcttaagcga gccatgagga agagcggcta ttatgcccag aatatcggcg agtcctcatt     1740

gcggaccatc cacctcgccc agttgagaga cgtcttgagg cagaaactgg gggaaagatt     1800

cgaccagaaa atcattgaca agacccttgc cctccttagt gggaagagcg tggacgaggc     1860

tgaaaaaatc tctgccgacg ccgtaacgcc ctgggttgtg ggtgagattg cttggttttg     1920

tgaacaggtg gcgaaggcgg aggccgataa cctggatgac aagaagctgc tgaaggtcct     1980

taaggaggac atagctgcca ttcgggtcaa tttgcagcag ggagtggata tcgcattgtc     2040

cggaagaatg gctacatcag gcatgatgac cgagctgggc aaggtagacg gagccatgag     2100

tatcgcacac gccatcacca cccaccaagt cgactcagac atcgactggt tcacagcagt     2160

agatgacctc caggagcagg ggtctgccca ccttgggaca caggagttct cttccggggt     2220

gttttatcgc tatgctaata tcaatctggc gcagctgcaa gaaaacctgg ggggagcctc     2280

tcgagagcag gccctggaga ttgcaactca cgtcgtgcat atgcttgcga cagaggtacc     2340

tggcgccaag cagaggacat acgctgcttt taatccagca gatatggtca tggtaaattt     2400

ctctgatatg cctctctcca tggccaacgc attcgagaag gcagtgaagg caaaggacgg     2460

gttcctgcag ccatcaattc aagcgtttaa tcagtattgg gacagagtgg cgaacggcta     2520

tggactgaac ggagccgcag ctcagtttag cctcagcgat gtcgatccca taactgcaca     2580

ggtgaaacag atgcctacgt tggaacagct gaagtcatgg gtaagaaata acggcgaagc     2640

cggcagcggc gagggcagag gcagcctgct gacctgcggc gacgtggagg agaaccccgg     2700

cccccccaag aaaaagagaa aagtaggatc gggcgattac aaagatcacg atggggacta     2760

caaggatcac gatattgact ataaggacga cgatgacaag ggatcgggca tggccgacga     2820

gattgacgca atggcacttt accgggcctg gcagcagttg gataatggtt catgtgccca     2880

gattcgcaga gttagtgaac ctgacgaact gagagatatc cccgcgtttt acagacttgt     2940

ccaaccgttc ggatgggaga acccacggca ccaacaagca ctccttcgaa tggtcttctg     3000

tttgtccgca ggaaaaaatg taatcagaca ccaagacaaa aagagcgagc aaaccacagg     3060

tatcagcctg ggcagggcac ttgccaactc tgggcggatc aacgaaagga gaatttttca     3120

gctgatacgc gctgatcgga ctgcggacat ggtgcagctg cgcagactcc ttactcatgc     3180

cgaacctgtc ctggattggc ccctgatggc acgcatgctg acttggtggg gaaagagaga     3240

aagacagcaa ctgcttgaag acttcgtgct cactacaaat aagaatgccg gatccggaga     3300

aggaagggga tccctcctca catgtggaga tgtcgaagaa aatcctggac ctcccaagaa     3360

aaagagaaaa gtaggatcgg gcatgcggag ctatctcatc ctgagactgg ccggaccaat     3420

gcaggcctgg ggacagccta ccttcgaagg tacacgcccc acaggccgct ttcctaccag     3480

gagcggcctg ctgggcctgc ttggcgcttg tcttgggatc cagcgcgatg atactagctc     3540

cctgcaagca ctgtcagaga gcgtgcagtt tgccgtaaga tgcgacgaac tgatccttga     3600

tgataggcgg gtcagtgtca ctggtctccg ggactaccac acggtgctgg gggcccggga     3660

ggattatagg ggcctgaaaa gtcacgagac gattcaaacc tggcgcgaat atctgtgcga     3720

tgccagcttc accgtggccc tgtggctgac tccacatgcc actatggtca tcagtgaact     3780

ggaaaaggct gttcttaagc ctcgatatac tccgtatctg ggccgccgga gttgtccact     3840

tacacaccca cttttcctcg gcacctgcca ggccagcgac cctcaaaagg cccttctgaa     3900

ttacgagcca gttggcggtg acatatacag cgaagagtcc gtgacgggac accatcttaa     3960

gttcaccgct cgggacgagc ccatgattac cctcccacgg cagttcgcat caagggagtg     4020

gtacgtcata aaggggggca tggatgtgag tcaggggtct ggggaggggc gggggtcttt     4080

gttgacttgc ggggatgttg aggagaaccc agggccaccc aagaaaaaga gaaaagtagg     4140

ctcaggcggt aaacccatcc caaacccctt gcttggtctc gactcaaccg gatcgggcat     4200

gtatctgtca aaggttatca ttgcacgcgc gtggagtagg gatctgtatc agctgcacca     4260

gggtctgtgg catcttttcc cgaaccgccc cgacgcggca cgagactttc tgtttcacgt     4320

tgaaaaaaga aacacccccg agggctgtca tgtgctcctg cagtctgccc agatgccggt     4380

gagcacagct gtggcgactg tgatcaagac caagcaggtc gagtttcagc tccaggtagg     4440

ggttccactg tattttcgcc tgagagctaa tccgatcaaa accatactgg ataatcagaa     4500

gaggctcgac agcaaaggaa atattaaaag gtgccgggtc ccgctcatca aagaggctga     4560

gcaaatcgct tggcttcaac ggaaactggg gaacgcagcc cgcgtggaag acgtccaccc     4620

gattagtgaa cggccccaat atttttccgg agacggaaag agcggcaaga ttcagacagt     4680

ctgtttcgag ggggtgctca ccatcaatga tgcccccgcc ctgatagacc tggtgcagca     4740

gggcataggc cccgctaaaa gcatgggatg cggactgctt agtctggcac cgctgggatc     4800

cggagagggc agaggaagtc tgctaacatg cggtgacgtc gaggagaatc ctggacctcc     4860

caagaaaaag agaaaagtag gcggctcaca attggtcaaa agcgaactgg aagagaaaaa     4920

atctgagctc agacacaagc tgaagtatgt gccccatgaa tacatagaac tcatagaaat     4980

agctcgaaac cccacgcagg accggatcct tgaaatgaaa gttatggagt tttttatgaa     5040

agtgtatggg tatcgaggag agcatcttgg tggaagtcgg aaaccggatg gggcaatata     5100

cactgttggg agccccattg actatggtgt gatagtggac accaaggcat acagcggggg     5160

atacaatctg ccgatcgggc aggcagatga gatgcagcgc tatgtggagg agaatcaaac     5220

taggaacaaa catattaacc caaacgaatg gtggaaagtg tatccctcat ctgttacgga     5280

gttcaagttc ctttttgtat ctggccactt taaaggaaac tataaagcac agctcacgcg     5340

acttaaccac atcaccaatt gtaacggtgc tgtactcagt gttgaggaac tcctgatcgg     5400

tggtgaaatg ataaaagctg gaaccttgac attggaggaa gtaaggagaa agtttaataa     5460

tggtgagatc aatttcagcg gctccgaaac gccgggtaca tccgagtccg cgactcctga     5520

gtcaggaggc agcggctcct ctggtggaag cggctcaagt ggagggatga atttgctcat     5580

tgataattgg attccggtgc gcccccggaa cggtgggaaa gtgcagatca tcaatttgca     5640

aagtctctac tgttccaggg accagtggag actcagcctg ccacgggatg atatggagct     5700

ggcggcgttg gctctgctcg tatgcatcgg ccagattatt gcgccagcaa aggatgacgt     5760

tgaattccgg catcggataa tgaaccccct tactgaagat gagttccagc agcttatcgc     5820

cccatggatc gacatgttct acctcaacca cgccgagcat ccttttatgc agaccaaggg     5880

agtcaaggcg aatgatgtga ctcccatgga gaagctgctg gccggtgtat ctggggcgac     5940

caactgcgca ttcgtgaatc agcctggaca gggggaggcc ctctgtggag gctgcactgc     6000

tatagcactt tttaaccaag ctaatcaagc ccccggcttt ggtggagggt ttaagagtgg     6060

attgaggggg ggcactcccg taaccacttt tgtgagggga attgatctga ggtctactgt     6120

gttgctgaac gtcctcacac tcccaaggct ccagaagcag ttcccaaacg aaagtcatac     6180

cgaaaaccag cccacatgga tcaagcccat caaatctaat gagagcatac cggctagcag     6240

tattggattt gtacggggtc tgttctggca gccagctcac atcgagctgt gtgatcctat     6300

tgggatcggc aagtgctctt gttgtgggca ggagtccaac cttaggtata ctggatttct     6360

gaaagagaag tttaccttta cagtaaatgg gctctggccc cacccccact caccttgcct     6420

tgtgacagtg aaaaaggggg aagtcgagga gaagtttctg gcctttacaa cttctgcccc     6480

ttcctggact cagatttcca gagtggtggt agataagata attcaaaacg agaatggcaa     6540

tagagtggcc gccgtggtga accagtttcg caacatcgcc cctcagtccc ccctggagct     6600

gattatgggc ggttatcgga ataaccaggc cagtatactc gagcgacggc acgatgtcct     6660

catgttcaat caaggttggc agcaatatgg caatgtgatt aacgagatcg taaccgtggg     6720

cctgggatat aagaccgccc tgcggaaggc gttgtatact tttgcagaag gctttaagaa     6780

taaggatttt aagggtgccg gcgtgagtgt ccatgaaaca gctgaacggc acttttatcg     6840

gcagtccgag ctgttgatac cagacgtgct ggctaatgtg aacttctcac aggccgacga     6900

agtgatcgct gatctgcggg ataaactgca ccaactgtgc gagatgctgt ttaatcaaag     6960

cgtcgctcct tatgcccacc acccaaagct gatctccacg ctggccctgg cgcgcgccac     7020

actttataaa catctccgcg aactgaaacc ccaggggggc cccagcaatg gctaataatc     7080

tagagggccc tattctatag tgtcacctaa atgctagagc tcgctgatca gcctcgactg     7140

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     7200

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     7260

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     7320

aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa     7380

ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta agcgcggcgg     7440

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     7500

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     7560

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     7620

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     7680

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     7740

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     7800

aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg tgtgtcagtt     7860

agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa     7920

ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag     7980

catgcatctc aattagtcag caaccatagt cccgccccta actccgccca tcccgcccct     8040

aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc     8100

agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag gcttttttgg     8160

aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg gatctgatca     8220

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc     8280

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc     8340

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga     8400

cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt ggctggccac     8460

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct     8520

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa     8580

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc     8640

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct     8700

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc     8760

caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg     8820

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct     8880

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct     8940

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca     9000

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct ggggttcgaa     9060

atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac cgccgccttc     9120

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc     9180

ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt     9240

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     9300

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct     9360

agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc     9420

acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga     9480

gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg     9540

tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg     9600

cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     9660

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     9720

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     9780

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     9840

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     9900

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     9960

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt    10020

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc    10080

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc    10140

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg    10200

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca    10260

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc    10320

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat    10380

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt    10440

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt    10500

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc    10560

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc    10620

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata    10680

ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg    10740

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc    10800

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct    10860

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa    10920

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt    10980

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca    11040

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac    11100

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca    11160

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt    11220

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc    11280

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca    11340

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata    11400

ctcatactct tcctttttca ttattattga agcatttatc agggttattg tctcatgagc    11460

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc    11520

cgaaaagtgc cacctgacgt c                                              11541


<210>  389
<211>  11541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hU6_CRISPR(Hsa07)_R, 
       CMV_NLSCas7_NLSCse2_NLSCas5_NLSCas6_NLSFokI30aaCas8

<400>  389
ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt       60

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat      120

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag      180

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct      240

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt      300

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg      360

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca      420

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt      480

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat      540

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac      600

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa      660

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt      720

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt      780

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa      840

gggcgacacg gaaatgttga atactcatac tcttcctttt tcattattat tgaagcattt      900

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa      960

taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtcgacgga tcgggagatc     1020

tcccgatccc ctatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca     1080

gtatctgctc cctgcttgtg tgttggaggt cgctgagtag tgcgcgagca aaatttaagc     1140

tacaacaagg caaggcttga ccgacaattg catgaagaat ctgcttaggg ttaggcgttt     1200

tgcgctgctt cgcgatgtac gggccagata tacgcgtgct acagggcgcg tggggatacc     1260

ccctagagcc ccagctggtt ctttccgaaa aaaatctaga cttctcaaat gcctgaggtt     1320

tcagagttat tgctcagcga gctccggttt atccccgctg gcgcggggaa ctcctgaagg     1380

cctaggcaaa gaagaacaca acttacggtt tatccccgct ggcgcgggga actcagactg     1440

tgtaacacca atgcaggcaa atcaaccggt ttatccccgc tggcgcgggg aactcgctag     1500

cccatggtat atctccttac cctatagtga gtcgtattag gatccggtgt ttcgtccttt     1560

ccacaagata tataaagcca agaaatcgaa atactttcaa gttacggtaa gcatatgata     1620

gtccatttta aaacataatt ttaaaactgc aaactaccca agaaattatt actttctacg     1680

tcacgtattt tgtactaata tctttgtgtt tacagtcaaa ttaattccaa ttatctctct     1740

aacagccttg tatcgtatat gcaaatatga aggaatcatg ggaaataggc cctcacgcgt     1800

tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     1860

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     1920

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     1980

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     2040

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     2100

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     2160

ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag     2220

cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt     2280

tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa     2340

atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctctctg gctaactaga     2400

gaacccactg cttactggct tatcgaaatt aatacgactc actataggga gacccaagct     2460

tggtaccgag ctcggatcgc caccatgccc aagaaaaaga gaaaagtagg atcgggcgaa     2520

cagaaactta tatctgagga ggacctcgga tcgggcatgt caaattttat taatattcat     2580

gttctgatca gtcatagccc gagttgcctg aatagagacg acatgaatat gcagaaagac     2640

gcaattttcg gtggcaagag gcgagtccga ataagcagcc aaagtcttaa gcgagccatg     2700

aggaagagcg gctattatgc ccagaatatc ggcgagtcct cattgcggac catccacctc     2760

gcccagttga gagacgtctt gaggcagaaa ctgggggaaa gattcgacca gaaaatcatt     2820

gacaagaccc ttgccctcct tagtgggaag agcgtggacg aggctgaaaa aatctctgcc     2880

gacgccgtaa cgccctgggt tgtgggtgag attgcttggt tttgtgaaca ggtggcgaag     2940

gcggaggccg ataacctgga tgacaagaag ctgctgaagg tccttaagga ggacatagct     3000

gccattcggg tcaatttgca gcagggagtg gatatcgcat tgtccggaag aatggctaca     3060

tcaggcatga tgaccgagct gggcaaggta gacggagcca tgagtatcgc acacgccatc     3120

accacccacc aagtcgactc agacatcgac tggttcacag cagtagatga cctccaggag     3180

caggggtctg cccaccttgg gacacaggag ttctcttccg gggtgtttta tcgctatgct     3240

aatatcaatc tggcgcagct gcaagaaaac ctggggggag cctctcgaga gcaggccctg     3300

gagattgcaa ctcacgtcgt gcatatgctt gcgacagagg tacctggcgc caagcagagg     3360

acatacgctg cttttaatcc agcagatatg gtcatggtaa atttctctga tatgcctctc     3420

tccatggcca acgcattcga gaaggcagtg aaggcaaagg acgggttcct gcagccatca     3480

attcaagcgt ttaatcagta ttgggacaga gtggcgaacg gctatggact gaacggagcc     3540

gcagctcagt ttagcctcag cgatgtcgat cccataactg cacaggtgaa acagatgcct     3600

acgttggaac agctgaagtc atgggtaaga aataacggcg aagccggcag cggcgagggc     3660

agaggcagcc tgctgacctg cggcgacgtg gaggagaacc ccggcccccc caagaaaaag     3720

agaaaagtag gatcgggcga ttacaaagat cacgatgggg actacaagga tcacgatatt     3780

gactataagg acgacgatga caagggatcg ggcatggccg acgagattga cgcaatggca     3840

ctttaccggg cctggcagca gttggataat ggttcatgtg cccagattcg cagagttagt     3900

gaacctgacg aactgagaga tatccccgcg ttttacagac ttgtccaacc gttcggatgg     3960

gagaacccac ggcaccaaca agcactcctt cgaatggtct tctgtttgtc cgcaggaaaa     4020

aatgtaatca gacaccaaga caaaaagagc gagcaaacca caggtatcag cctgggcagg     4080

gcacttgcca actctgggcg gatcaacgaa aggagaattt ttcagctgat acgcgctgat     4140

cggactgcgg acatggtgca gctgcgcaga ctccttactc atgccgaacc tgtcctggat     4200

tggcccctga tggcacgcat gctgacttgg tggggaaaga gagaaagaca gcaactgctt     4260

gaagacttcg tgctcactac aaataagaat gccggatccg gagaaggaag gggatccctc     4320

ctcacatgtg gagatgtcga agaaaatcct ggacctccca agaaaaagag aaaagtagga     4380

tcgggcatgc ggagctatct catcctgaga ctggccggac caatgcaggc ctggggacag     4440

cctaccttcg aaggtacacg ccccacaggc cgctttccta ccaggagcgg cctgctgggc     4500

ctgcttggcg cttgtcttgg gatccagcgc gatgatacta gctccctgca agcactgtca     4560

gagagcgtgc agtttgccgt aagatgcgac gaactgatcc ttgatgatag gcgggtcagt     4620

gtcactggtc tccgggacta ccacacggtg ctgggggccc gggaggatta taggggcctg     4680

aaaagtcacg agacgattca aacctggcgc gaatatctgt gcgatgccag cttcaccgtg     4740

gccctgtggc tgactccaca tgccactatg gtcatcagtg aactggaaaa ggctgttctt     4800

aagcctcgat atactccgta tctgggccgc cggagttgtc cacttacaca cccacttttc     4860

ctcggcacct gccaggccag cgaccctcaa aaggcccttc tgaattacga gccagttggc     4920

ggtgacatat acagcgaaga gtccgtgacg ggacaccatc ttaagttcac cgctcgggac     4980

gagcccatga ttaccctccc acggcagttc gcatcaaggg agtggtacgt cataaagggg     5040

ggcatggatg tgagtcaggg gtctggggag gggcgggggt ctttgttgac ttgcggggat     5100

gttgaggaga acccagggcc acccaagaaa aagagaaaag taggctcagg cggtaaaccc     5160

atcccaaacc ccttgcttgg tctcgactca accggatcgg gcatgtatct gtcaaaggtt     5220

atcattgcac gcgcgtggag tagggatctg tatcagctgc accagggtct gtggcatctt     5280

ttcccgaacc gccccgacgc ggcacgagac tttctgtttc acgttgaaaa aagaaacacc     5340

cccgagggct gtcatgtgct cctgcagtct gcccagatgc cggtgagcac agctgtggcg     5400

actgtgatca agaccaagca ggtcgagttt cagctccagg taggggttcc actgtatttt     5460

cgcctgagag ctaatccgat caaaaccata ctggataatc agaagaggct cgacagcaaa     5520

ggaaatatta aaaggtgccg ggtcccgctc atcaaagagg ctgagcaaat cgcttggctt     5580

caacggaaac tggggaacgc agcccgcgtg gaagacgtcc acccgattag tgaacggccc     5640

caatattttt ccggagacgg aaagagcggc aagattcaga cagtctgttt cgagggggtg     5700

ctcaccatca atgatgcccc cgccctgata gacctggtgc agcagggcat aggccccgct     5760

aaaagcatgg gatgcggact gcttagtctg gcaccgctgg gatccggaga gggcagagga     5820

agtctgctaa catgcggtga cgtcgaggag aatcctggac ctcccaagaa aaagagaaaa     5880

gtaggcggct cacaattggt caaaagcgaa ctggaagaga aaaaatctga gctcagacac     5940

aagctgaagt atgtgcccca tgaatacata gaactcatag aaatagctcg aaaccccacg     6000

caggaccgga tccttgaaat gaaagttatg gagtttttta tgaaagtgta tgggtatcga     6060

ggagagcatc ttggtggaag tcggaaaccg gatggggcaa tatacactgt tgggagcccc     6120

attgactatg gtgtgatagt ggacaccaag gcatacagcg ggggatacaa tctgccgatc     6180

gggcaggcag atgagatgca gcgctatgtg gaggagaatc aaactaggaa caaacatatt     6240

aacccaaacg aatggtggaa agtgtatccc tcatctgtta cggagttcaa gttccttttt     6300

gtatctggcc actttaaagg aaactataaa gcacagctca cgcgacttaa ccacatcacc     6360

aattgtaacg gtgctgtact cagtgttgag gaactcctga tcggtggtga aatgataaaa     6420

gctggaacct tgacattgga ggaagtaagg agaaagttta ataatggtga gatcaatttc     6480

agcggctccg aaacgccggg tacatccgag tccgcgactc ctgagtcagg aggcagcggc     6540

tcctctggtg gaagcggctc aagtggaggg atgaatttgc tcattgataa ttggattccg     6600

gtgcgccccc ggaacggtgg gaaagtgcag atcatcaatt tgcaaagtct ctactgttcc     6660

agggaccagt ggagactcag cctgccacgg gatgatatgg agctggcggc gttggctctg     6720

ctcgtatgca tcggccagat tattgcgcca gcaaaggatg acgttgaatt ccggcatcgg     6780

ataatgaacc cccttactga agatgagttc cagcagctta tcgccccatg gatcgacatg     6840

ttctacctca accacgccga gcatcctttt atgcagacca agggagtcaa ggcgaatgat     6900

gtgactccca tggagaagct gctggccggt gtatctgggg cgaccaactg cgcattcgtg     6960

aatcagcctg gacaggggga ggccctctgt ggaggctgca ctgctatagc actttttaac     7020

caagctaatc aagcccccgg ctttggtgga gggtttaaga gtggattgag ggggggcact     7080

cccgtaacca cttttgtgag gggaattgat ctgaggtcta ctgtgttgct gaacgtcctc     7140

acactcccaa ggctccagaa gcagttccca aacgaaagtc ataccgaaaa ccagcccaca     7200

tggatcaagc ccatcaaatc taatgagagc ataccggcta gcagtattgg atttgtacgg     7260

ggtctgttct ggcagccagc tcacatcgag ctgtgtgatc ctattgggat cggcaagtgc     7320

tcttgttgtg ggcaggagtc caaccttagg tatactggat ttctgaaaga gaagtttacc     7380

tttacagtaa atgggctctg gccccacccc cactcacctt gccttgtgac agtgaaaaag     7440

ggggaagtcg aggagaagtt tctggccttt acaacttctg ccccttcctg gactcagatt     7500

tccagagtgg tggtagataa gataattcaa aacgagaatg gcaatagagt ggccgccgtg     7560

gtgaaccagt ttcgcaacat cgcccctcag tcccccctgg agctgattat gggcggttat     7620

cggaataacc aggccagtat actcgagcga cggcacgatg tcctcatgtt caatcaaggt     7680

tggcagcaat atggcaatgt gattaacgag atcgtaaccg tgggcctggg atataagacc     7740

gccctgcgga aggcgttgta tacttttgca gaaggcttta agaataagga ttttaagggt     7800

gccggcgtga gtgtccatga aacagctgaa cggcactttt atcggcagtc cgagctgttg     7860

ataccagacg tgctggctaa tgtgaacttc tcacaggccg acgaagtgat cgctgatctg     7920

cgggataaac tgcaccaact gtgcgagatg ctgtttaatc aaagcgtcgc tccttatgcc     7980

caccacccaa agctgatctc cacgctggcc ctggcgcgcg ccacacttta taaacatctc     8040

cgcgaactga aaccccaggg gggccccagc aatggctaat aatctagagg gccctattct     8100

atagtgtcac ctaaatgcta gagctcgctg atcagcctcg actgtgcctt ctagttgcca     8160

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     8220

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     8280

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     8340

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctctag     8400

ggggtatccc cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     8460

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     8520

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     8580

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     8640

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     8700

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     8760

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     8820

acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc     8880

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg     8940

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     9000

tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc     9060

gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc     9120

tctgcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc     9180

aaaaagctcc cgggagcttg tatatccatt ttcggatctg atcaagagac aggatgagga     9240

tcgtttcgca tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag     9300

aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc     9360

cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg     9420

aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc     9480

gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg     9540

ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct     9600

gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg     9660

aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat     9720

ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc     9780

atgcccgacg gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg     9840

gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc     9900

tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct     9960

gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat    10020

cgccttcttg acgagttctt ctgagcggga ctctggggtt cgaaatgacc gaccaagcga    10080

cgcccaacct gccatcacga gatttcgatt ccaccgccgc cttctatgaa aggttgggct    10140

tcggaatcgt tttccgggac gccggctgga tgatcctcca gcgcggggat ctcatgctgg    10200

agttcttcgc ccaccccaac ttgtttattg cagcttataa tggttacaaa taaagcaata    10260

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca    10320

aactcatcaa tgtatcttat catgtctgta taccgtcgac ctctagctag agcttggcgt    10380

aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca    10440

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat    10500

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt    10560

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct    10620

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa    10680

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa    10740

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc    10800

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga    10860

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc    10920

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt    10980

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct    11040

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg    11100

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta    11160

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct    11220

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa    11280

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt    11340

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta    11400

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat    11460

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa    11520

gtatatatga gtaaacttgg t                                              11541


<210>  390
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: StrepIIHRV3C-Cse2

<400>  390
atggcaagct ggagccaccc gcagttcgaa aagggtgcac ttgaagtcct ctttcaggga       60

cccgggtacc agatggctga tgaaattgat gcaatggctt tatatcgagc ctggcaacaa      120

ctggataatg gatcatgtgc gcaaattaga cgtgtttcag aacctgatga attacgcgat      180

atccctgcgt tttataggct ggtgcaacct tttggttggg aaaacccacg tcaccagcag      240

gctcttttgc gcatggtgtt ttgcctgagc gcaggaaaga atgtcatccg acatcaggac      300

aaaaaatcgg agcaaacaac aggtatctcg ttgggaagag ctttagccaa tagtggaaga      360

attaacgagc gccgtatctt tcaattaatt cgggctgaca gaacagccga tatggtccag      420

ttacgtcgat tacttactca cgccgaaccc gtacttgact ggccattaat ggccaggatg      480

ttgacctggt ggggaaagcg cgaacgccag caacttctgg aagattttgt attgaccaca      540

aacaaaaatg cgtaa                                                       555


<210>  391
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: StrepIIHRV3C-Cse2

<400>  391

Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Glu Val 
1               5                   10                  15      


Leu Phe Gln Gly Pro Gly Tyr Gln Met Ala Asp Glu Ile Asp Ala Met 
            20                  25                  30          


Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln 
        35                  40                  45              


Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe 
    50                  55                  60                  


Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln 
65                  70                  75                  80  


Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile 
                85                  90                  95      


Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly 
            100                 105                 110         


Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln 
        115                 120                 125             


Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu 
    130                 135                 140                 


Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met 
145                 150                 155                 160 


Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe 
                165                 170                 175     


Val Leu Thr Thr Asn Lys Asn Ala 
            180                 


<210>  392
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6HRV3CCse2

<400>  392
atggctgagc atcaccacca tcatcacggt gcacttgaag tcctctttca gggacccggg       60

taccagatgg ctgatgaaat tgatgcaatg gctttatatc gagcctggca acaactggat      120

aatggatcat gtgcgcaaat tagacgtgtt tcagaacctg atgaattacg cgatatccct      180

gcgttttata ggctggtgca accttttggt tgggaaaacc cacgtcacca gcaggctctt      240

ttgcgcatgg tgttttgcct gagcgcagga aagaatgtca tccgacatca ggacaaaaaa      300

tcggagcaaa caacaggtat ctcgttggga agagctttag ccaatagtgg aagaattaac      360

gagcgccgta tctttcaatt aattcgggct gacagaacag ccgatatggt ccagttacgt      420

cgattactta ctcacgccga acccgtactt gactggccat taatggccag gatgttgacc      480

tggtggggaa agcgcgaacg ccagcaactt ctggaagatt ttgtattgac cacaaacaaa      540

aatgcgtaa                                                              549


<210>  393
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6HRV3CCse2

<400>  393

Met Ala Glu His His His His His His Gly Ala Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro Gly Tyr Gln Met Ala Asp Glu Ile Asp Ala Met Ala Leu 
            20                  25                  30          


Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg 
        35                  40                  45              


Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg 
    50                  55                  60                  


Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu 
65                  70                  75                  80  


Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His 
                85                  90                  95      


Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala 
            100                 105                 110         


Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile 
        115                 120                 125             


Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr 
    130                 135                 140                 


His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr 
145                 150                 155                 160 


Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu 
                165                 170                 175     


Thr Thr Asn Lys Asn Ala 
            180         


<210>  394
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCse2

<400>  394
atgccgaaaa aaaagcggaa ggtcggatca ggaatggccg acgagattga cgcaatggca       60

ctttaccggg cctggcagca gttggataat ggttcatgtg cccagattcg cagagttagt      120

gaacctgacg aactgagaga tatccccgcg ttttacagac ttgtccaacc gttcggatgg      180

gagaacccac ggcaccaaca agcactcctt cgaatggtct tctgtttgtc cgcaggaaaa      240

aatgtaatca gacaccaaga caaaaagagc gagcaaacca caggtatcag cctgggcagg      300

gcacttgcca actctgggcg gatcaacgaa aggagaattt ttcagctgat acgcgctgat      360

cggactgcgg acatggtgca gctgcgcaga ctccttactc atgccgaacc tgtcctggat      420

tggcccctga tggcacgcat gctgacttgg tggggaaaga gagaaagaca gcaactgctt      480

gaagacttcg tgctcactac aaataagaat gcctaa                                516


<210>  395
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCse2

<400>  395

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ala Asp Glu Ile 
1               5                   10                  15      


Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser 
            20                  25                  30          


Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile 
        35                  40                  45              


Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg 
    50                  55                  60                  


His Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys 
65                  70                  75                  80  


Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile 
                85                  90                  95      


Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg 
            100                 105                 110         


Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu 
        115                 120                 125             


Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met 
    130                 135                 140                 


Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu 
145                 150                 155                 160 


Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
                165                 170     


<210>  396
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas5

<400>  396
atgcccaaga aaaagagaaa agtaggatcg ggcatgcgga gctatctcat cctgagactg       60

gccggaccaa tgcaggcctg gggacagcct accttcgaag gtacacgccc cacaggccgc      120

tttcctacca ggagcggcct gctgggcctg cttggcgctt gtcttgggat ccagcgcgat      180

gatactagct ccctgcaagc actgtcagag agcgtgcagt ttgccgtaag atgcgacgaa      240

ctgatccttg atgataggcg ggtcagtgtc actggtctcc gggactacca cacggtgctg      300

ggggcccggg aggattatag gggcctgaaa agtcacgaga cgattcaaac ctggcgcgaa      360

tatctgtgcg atgccagctt caccgtggcc ctgtggctga ctccacatgc cactatggtc      420

atcagtgaac tggaaaaggc tgttcttaag cctcgatata ctccgtatct gggccgccgg      480

agttgtccac ttacacaccc acttttcctc ggcacctgcc aggccagcga ccctcaaaag      540

gcccttctga attacgagcc agttggcggt gacatataca gcgaagagtc cgtgacggga      600

caccatctta agttcaccgc tcgggacgag cccatgatta ccctcccacg gcagttcgca      660

tcaagggagt ggtacgtcat aaaggggggc atggatgtga gtcagtaa                   708


<210>  397
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLSCas5

<400>  397

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Arg Ser Tyr Leu 
1               5                   10                  15      


Ile Leu Arg Leu Ala Gly Pro Met Gln Ala Trp Gly Gln Pro Thr Phe 
            20                  25                  30          


Glu Gly Thr Arg Pro Thr Gly Arg Phe Pro Thr Arg Ser Gly Leu Leu 
        35                  40                  45              


Gly Leu Leu Gly Ala Cys Leu Gly Ile Gln Arg Asp Asp Thr Ser Ser 
    50                  55                  60                  


Leu Gln Ala Leu Ser Glu Ser Val Gln Phe Ala Val Arg Cys Asp Glu 
65                  70                  75                  80  


Leu Ile Leu Asp Asp Arg Arg Val Ser Val Thr Gly Leu Arg Asp Tyr 
                85                  90                  95      


His Thr Val Leu Gly Ala Arg Glu Asp Tyr Arg Gly Leu Lys Ser His 
            100                 105                 110         


Glu Thr Ile Gln Thr Trp Arg Glu Tyr Leu Cys Asp Ala Ser Phe Thr 
        115                 120                 125             


Val Ala Leu Trp Leu Thr Pro His Ala Thr Met Val Ile Ser Glu Leu 
    130                 135                 140                 


Glu Lys Ala Val Leu Lys Pro Arg Tyr Thr Pro Tyr Leu Gly Arg Arg 
145                 150                 155                 160 


Ser Cys Pro Leu Thr His Pro Leu Phe Leu Gly Thr Cys Gln Ala Ser 
                165                 170                 175     


Asp Pro Gln Lys Ala Leu Leu Asn Tyr Glu Pro Val Gly Gly Asp Ile 
            180                 185                 190         


Tyr Ser Glu Glu Ser Val Thr Gly His His Leu Lys Phe Thr Ala Arg 
        195                 200                 205             


Asp Glu Pro Met Ile Thr Leu Pro Arg Gln Phe Ala Ser Arg Glu Trp 
    210                 215                 220                 


Tyr Val Ile Lys Gly Gly Met Asp Val Ser Gln 
225                 230                 235 


<210>  398
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas6

<400>  398
atgccaaaga aaaaacgtaa ggttggcggt agcatgtacc tcagcaaagt catcattgcc       60

agggcctgga gcagggatct ttaccaactt caccagggat tatggcattt atttccaaac      120

agaccggatg ctgctcgtga ttttcttttt catgttgaga agcgaaacac accagaaggc      180

tgtcatgttt tattgcagtc agcgcaaatg cctgtttcaa ctgccgttgc gacagtcatt      240

aaaactaaac aggttgaatt tcaacttcag gttggtgttc cactctattt tcggcttcgg      300

gcaaatccga tcaaaactat tctcgacaat caaaagcgcc tggacagtaa agggaatatt      360

aaacgctgtc gggttccgtt aataaaagaa gcagaacaaa tcgcgtggtt gcaacgtaaa      420

ttgggcaatg cggcgcgcgt tgaagatgtg catcccatat cggaacggcc acagtatttt      480

tctggtgatg gtaaaagtgg aaagatccaa acggtttgct ttgaaggtgt gctcaccatc      540

aacgacgcgc cagcgttaat agatcttgta cagcaaggta ttgggccagc taaatcgatg      600

ggatgtggct tgctatcttt ggctccactg tga                                   633


<210>  399
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas6

<400>  399

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Met Tyr Leu Ser Lys 
1               5                   10                  15      


Val Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu Tyr Gln Leu His Gln 
            20                  25                  30          


Gly Leu Trp His Leu Phe Pro Asn Arg Pro Asp Ala Ala Arg Asp Phe 
        35                  40                  45              


Leu Phe His Val Glu Lys Arg Asn Thr Pro Glu Gly Cys His Val Leu 
    50                  55                  60                  


Leu Gln Ser Ala Gln Met Pro Val Ser Thr Ala Val Ala Thr Val Ile 
65                  70                  75                  80  


Lys Thr Lys Gln Val Glu Phe Gln Leu Gln Val Gly Val Pro Leu Tyr 
                85                  90                  95      


Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile Leu Asp Asn Gln Lys 
            100                 105                 110         


Arg Leu Asp Ser Lys Gly Asn Ile Lys Arg Cys Arg Val Pro Leu Ile 
        115                 120                 125             


Lys Glu Ala Glu Gln Ile Ala Trp Leu Gln Arg Lys Leu Gly Asn Ala 
    130                 135                 140                 


Ala Arg Val Glu Asp Val His Pro Ile Ser Glu Arg Pro Gln Tyr Phe 
145                 150                 155                 160 


Ser Gly Asp Gly Lys Ser Gly Lys Ile Gln Thr Val Cys Phe Glu Gly 
                165                 170                 175     


Val Leu Thr Ile Asn Asp Ala Pro Ala Leu Ile Asp Leu Val Gln Gln 
            180                 185                 190         


Gly Ile Gly Pro Ala Lys Ser Met Gly Cys Gly Leu Leu Ser Leu Ala 
        195                 200                 205             


Pro Leu 
    210 


<210>  400
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-HA-Cas6

<400>  400
atgccaaaga aaaaacgtaa ggttggcggt agctatccgt acgatgttcc agactacgcc       60

ggcggctcca tgtacctcag caaagtcatc attgccaggg cctggagcag ggatctttac      120

caacttcacc agggattatg gcatttattt ccaaacagac cggatgctgc tcgtgatttt      180

ctttttcatg ttgagaagcg aaacacacca gaaggctgtc atgttttatt gcagtcagcg      240

caaatgcctg tttcaactgc cgttgcgaca gtcattaaaa ctaaacaggt tgaatttcaa      300

cttcaggttg gtgttccact ctattttcgg cttcgggcaa atccgatcaa aactattctc      360

gacaatcaaa agcgcctgga cagtaaaggg aatattaaac gctgtcgggt tccgttaata      420

aaagaagcag aacaaatcgc gtggttgcaa cgtaaattgg gcaatgcggc gcgcgttgaa      480

gatgtgcatc ccatatcgga acggccacag tatttttctg gtgatggtaa aagtggaaag      540

atccaaacgg tttgctttga aggtgtgctc accatcaacg acgcgccagc gttaatagat      600

cttgtacagc aaggtattgg gccagctaaa tcgatgggat gtggcttgct atctttggct      660

ccactgtga                                                              669


<210>  401
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-HA-Cas6

<400>  401

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Tyr Pro Tyr Asp Val 
1               5                   10                  15      


Pro Asp Tyr Ala Gly Gly Ser Met Tyr Leu Ser Lys Val Ile Ile Ala 
            20                  25                  30          


Arg Ala Trp Ser Arg Asp Leu Tyr Gln Leu His Gln Gly Leu Trp His 
        35                  40                  45              


Leu Phe Pro Asn Arg Pro Asp Ala Ala Arg Asp Phe Leu Phe His Val 
    50                  55                  60                  


Glu Lys Arg Asn Thr Pro Glu Gly Cys His Val Leu Leu Gln Ser Ala 
65                  70                  75                  80  


Gln Met Pro Val Ser Thr Ala Val Ala Thr Val Ile Lys Thr Lys Gln 
                85                  90                  95      


Val Glu Phe Gln Leu Gln Val Gly Val Pro Leu Tyr Phe Arg Leu Arg 
            100                 105                 110         


Ala Asn Pro Ile Lys Thr Ile Leu Asp Asn Gln Lys Arg Leu Asp Ser 
        115                 120                 125             


Lys Gly Asn Ile Lys Arg Cys Arg Val Pro Leu Ile Lys Glu Ala Glu 
    130                 135                 140                 


Gln Ile Ala Trp Leu Gln Arg Lys Leu Gly Asn Ala Ala Arg Val Glu 
145                 150                 155                 160 


Asp Val His Pro Ile Ser Glu Arg Pro Gln Tyr Phe Ser Gly Asp Gly 
                165                 170                 175     


Lys Ser Gly Lys Ile Gln Thr Val Cys Phe Glu Gly Val Leu Thr Ile 
            180                 185                 190         


Asn Asp Ala Pro Ala Leu Ile Asp Leu Val Gln Gln Gly Ile Gly Pro 
        195                 200                 205             


Ala Lys Ser Met Gly Cys Gly Leu Leu Ser Leu Ala Pro Leu 
    210                 215                 220         


<210>  402
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas6

<400>  402
atgcccaaga aaaagagaaa agtaggatcg ggcatgtatc tgtcaaaggt tatcattgca       60

cgcgcgtgga gtagggatct gtatcagctg caccagggtc tgtggcatct tttcccgaac      120

cgccccgacg cggcacgaga ctttctgttt cacgttgaaa aaagaaacac ccccgagggc      180

tgtcatgtgc tcctgcagtc tgcccagatg ccggtgagca cagctgtggc gactgtgatc      240

aagaccaagc aggtcgagtt tcagctccag gtaggggttc cactgtattt tcgcctgaga      300

gctaatccga tcaaaaccat actggataat cagaagaggc tcgacagcaa aggaaatatt      360

aaaaggtgcc gggtcccgct catcaaagag gctgagcaaa tcgcttggct tcaacggaaa      420

ctggggaacg cagcccgcgt ggaagacgtc cacccgatta gtgaacggcc ccaatatttt      480

tccggagacg gaaagagcgg caagattcag acagtctgtt tcgagggggt gctcaccatc      540

aatgatgccc ccgccctgat agacctggtg cagcagggca taggccccgc taaaagcatg      600

ggatgcggac tgcttagtct ggcaccgctg taa                                   633


<210>  403
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas6

<400>  403

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Tyr Leu Ser Lys 
1               5                   10                  15      


Val Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu Tyr Gln Leu His Gln 
            20                  25                  30          


Gly Leu Trp His Leu Phe Pro Asn Arg Pro Asp Ala Ala Arg Asp Phe 
        35                  40                  45              


Leu Phe His Val Glu Lys Arg Asn Thr Pro Glu Gly Cys His Val Leu 
    50                  55                  60                  


Leu Gln Ser Ala Gln Met Pro Val Ser Thr Ala Val Ala Thr Val Ile 
65                  70                  75                  80  


Lys Thr Lys Gln Val Glu Phe Gln Leu Gln Val Gly Val Pro Leu Tyr 
                85                  90                  95      


Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile Leu Asp Asn Gln Lys 
            100                 105                 110         


Arg Leu Asp Ser Lys Gly Asn Ile Lys Arg Cys Arg Val Pro Leu Ile 
        115                 120                 125             


Lys Glu Ala Glu Gln Ile Ala Trp Leu Gln Arg Lys Leu Gly Asn Ala 
    130                 135                 140                 


Ala Arg Val Glu Asp Val His Pro Ile Ser Glu Arg Pro Gln Tyr Phe 
145                 150                 155                 160 


Ser Gly Asp Gly Lys Ser Gly Lys Ile Gln Thr Val Cys Phe Glu Gly 
                165                 170                 175     


Val Leu Thr Ile Asn Asp Ala Pro Ala Leu Ile Asp Leu Val Gln Gln 
            180                 185                 190         


Gly Ile Gly Pro Ala Lys Ser Met Gly Cys Gly Leu Leu Ser Leu Ala 
        195                 200                 205             


Pro Leu 
    210 


<210>  404
<211>  1122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas7-NLS

<400>  404
atgtctaact ttatcaatat tcatgttctg atctctcaca gcccttcatg tctgaaccgc       60

gacgatatga acatgcagaa agacgctatt ttcggcggca aaagacgagt aagaatttca      120

agtcaaagcc ttaaacgtgc gatgcgtaaa agtggttatt acgcacaaaa tattggtgaa      180

tccagtctca gaaccattca tcttgcacaa ttacgtgatg ttcttcggca aaaacttggt      240

gaacgttttg accaaaaaat catcgataag acattagcgc tgctctccgg taaatcagtt      300

gatgaagccg aaaagatttc tgccgatgcg gttactccct gggttgtggg agaaatagcc      360

tggttctgtg agcaggttgc aaaagcagag gctgataatc tggatgataa aaagctgctc      420

aaagttctta aggaagatat tgccgccata cgtgtgaatt tacagcaggg tgttgatatt      480

gcgcttagtg gaagaatggc aaccagcggc atgatgactg agttgggaaa agttgatggt      540

gcaatgtcca ttgcgcatgc gatcactact catcaggttg attctgatat tgactggttc      600

accgctgtag atgatttaca ggaacaaggt tctgcacatc tgggaactca ggaattttca      660

tcgggtgttt tttatcgtta tgccaacatt aacctcgctc aacttcagga aaatttaggt      720

ggtgcctcca gggagcaggc tctggaaatt gcaacccatg ttgttcatat gctggcaaca      780

gaggtccctg gagcaaaaca gcgtacttat gccgctttta accctgcgga tatggtaatg      840

gttaatttct ccgatatgcc actttctatg gcaaatgctt ttgaaaaagc ggttaaagcg      900

aaagatggct ttttgcaacc gtctatacag gcgtttaatc aatattggga tcgcgttgcc      960

aatggatatg gtctgaacgg agctgctgcg caattcagct tatctgatgt agacccaatt     1020

actgctcaag ttaaacaaat gcctacttta gaacagttaa aatcctgggt tcgtaataat     1080

ggcgaggcgg gcggtagccc aaagaaaaaa cgtaaggttt ga                        1122


<210>  405
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas7-NLS

<400>  405

Met Ser Asn Phe Ile Asn Ile His Val Leu Ile Ser His Ser Pro Ser 
1               5                   10                  15      


Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly 
            20                  25                  30          


Gly Lys Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met 
        35                  40                  45              


Arg Lys Ser Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg 
    50                  55                  60                  


Thr Ile His Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly 
65                  70                  75                  80  


Glu Arg Phe Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser 
                85                  90                  95      


Gly Lys Ser Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr 
            100                 105                 110         


Pro Trp Val Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys 
        115                 120                 125             


Ala Glu Ala Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys 
    130                 135                 140                 


Glu Asp Ile Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile 
145                 150                 155                 160 


Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly 
                165                 170                 175     


Lys Val Asp Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Gln 
            180                 185                 190         


Val Asp Ser Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu 
        195                 200                 205             


Gln Gly Ser Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe 
    210                 215                 220                 


Tyr Arg Tyr Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly 
225                 230                 235                 240 


Gly Ala Ser Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Val His 
                245                 250                 255     


Met Leu Ala Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala 
            260                 265                 270         


Phe Asn Pro Ala Asp Met Val Met Val Asn Phe Ser Asp Met Pro Leu 
        275                 280                 285             


Ser Met Ala Asn Ala Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe 
    290                 295                 300                 


Leu Gln Pro Ser Ile Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala 
305                 310                 315                 320 


Asn Gly Tyr Gly Leu Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp 
                325                 330                 335     


Val Asp Pro Ile Thr Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln 
            340                 345                 350         


Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala Gly Gly Ser Pro Lys 
        355                 360                 365             


Lys Lys Arg Lys Val 
    370             


<210>  406
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas7-HA-NLS

<400>  406
atgtctaact ttatcaatat tcatgttctg atctctcaca gcccttcatg tctgaaccgc       60

gacgatatga acatgcagaa agacgctatt ttcggcggca aaagacgagt aagaatttca      120

agtcaaagcc ttaaacgtgc gatgcgtaaa agtggttatt acgcacaaaa tattggtgaa      180

tccagtctca gaaccattca tcttgcacaa ttacgtgatg ttcttcggca aaaacttggt      240

gaacgttttg accaaaaaat catcgataag acattagcgc tgctctccgg taaatcagtt      300

gatgaagccg aaaagatttc tgccgatgcg gttactccct gggttgtggg agaaatagcc      360

tggttctgtg agcaggttgc aaaagcagag gctgataatc tggatgataa aaagctgctc      420

aaagttctta aggaagatat tgccgccata cgtgtgaatt tacagcaggg tgttgatatt      480

gcgcttagtg gaagaatggc aaccagcggc atgatgactg agttgggaaa agttgatggt      540

gcaatgtcca ttgcgcatgc gatcactact catcaggttg attctgatat tgactggttc      600

accgctgtag atgatttaca ggaacaaggt tctgcacatc tgggaactca ggaattttca      660

tcgggtgttt tttatcgtta tgccaacatt aacctcgctc aacttcagga aaatttaggt      720

ggtgcctcca gggagcaggc tctggaaatt gcaacccatg ttgttcatat gctggcaaca      780

gaggtccctg gagcaaaaca gcgtacttat gccgctttta accctgcgga tatggtaatg      840

gttaatttct ccgatatgcc actttctatg gcaaatgctt ttgaaaaagc ggttaaagcg      900

aaagatggct ttttgcaacc gtctatacag gcgtttaatc aatattggga tcgcgttgcc      960

aatggatatg gtctgaacgg agctgctgcg caattcagct tatctgatgt agacccaatt     1020

actgctcaag ttaaacaaat gcctacttta gaacagttaa aatcctgggt tcgtaataat     1080

ggcgaggcgg gcggctccta tccgtacgat gttccagact acgccggcgg tagcccaaag     1140

aaaaaacgta aggtttga                                                   1158


<210>  407
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas7-HA-NLS

<400>  407

Met Ser Asn Phe Ile Asn Ile His Val Leu Ile Ser His Ser Pro Ser 
1               5                   10                  15      


Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly 
            20                  25                  30          


Gly Lys Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met 
        35                  40                  45              


Arg Lys Ser Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg 
    50                  55                  60                  


Thr Ile His Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly 
65                  70                  75                  80  


Glu Arg Phe Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser 
                85                  90                  95      


Gly Lys Ser Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr 
            100                 105                 110         


Pro Trp Val Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys 
        115                 120                 125             


Ala Glu Ala Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys 
    130                 135                 140                 


Glu Asp Ile Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile 
145                 150                 155                 160 


Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly 
                165                 170                 175     


Lys Val Asp Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Gln 
            180                 185                 190         


Val Asp Ser Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu 
        195                 200                 205             


Gln Gly Ser Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe 
    210                 215                 220                 


Tyr Arg Tyr Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly 
225                 230                 235                 240 


Gly Ala Ser Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Val His 
                245                 250                 255     


Met Leu Ala Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala 
            260                 265                 270         


Phe Asn Pro Ala Asp Met Val Met Val Asn Phe Ser Asp Met Pro Leu 
        275                 280                 285             


Ser Met Ala Asn Ala Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe 
    290                 295                 300                 


Leu Gln Pro Ser Ile Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala 
305                 310                 315                 320 


Asn Gly Tyr Gly Leu Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp 
                325                 330                 335     


Val Asp Pro Ile Thr Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln 
            340                 345                 350         


Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala Gly Gly Ser Tyr Pro 
        355                 360                 365             


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Ser Pro Lys Lys Lys Arg Lys 
    370                 375                 380                 


Val 
385 


<210>  408
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas7

<400>  408
atgccgaaaa aaaagcggaa ggtcggatca ggaatgtcaa attttattaa tattcatgtt       60

ctgatcagtc atagcccgag ttgcctgaat agagacgaca tgaatatgca gaaagacgca      120

attttcggtg gcaagaggcg agtccgaata agcagccaaa gtcttaagcg agccatgagg      180

aagagcggct attatgccca gaatatcggc gagtcctcat tgcggaccat ccacctcgcc      240

cagttgagag acgtcttgag gcagaaactg ggggaaagat tcgaccagaa aatcattgac      300

aagacccttg ccctccttag tgggaagagc gtggacgagg ctgaaaaaat ctctgccgac      360

gccgtaacgc cctgggttgt gggtgagatt gcttggtttt gtgaacaggt ggcgaaggcg      420

gaggccgata acctggatga caagaagctg ctgaaggtcc ttaaggagga catagctgcc      480

attcgggtca atttgcagca gggagtggat atcgcattgt ccggaagaat ggctacatca      540

ggcatgatga ccgagctggg caaggtagac ggagccatga gtatcgcaca cgccatcacc      600

acccaccaag tcgactcaga catcgactgg ttcacagcag tagatgacct ccaggagcag      660

gggtctgccc accttgggac acaggagttc tcttccgggg tgttttatcg ctatgctaat      720

atcaatctgg cgcagctgca agaaaacctg gggggagcct ctcgagagca ggccctggag      780

attgcaactc acgtcgtgca tatgcttgcg acagaggtac ctggcgccaa gcagaggaca      840

tacgctgctt ttaatccagc agatatggtc atggtaaatt tctctgatat gcctctctcc      900

atggccaacg cattcgagaa ggcagtgaag gcaaaggacg ggttcctgca gccatcaatt      960

caagcgttta atcagtattg ggacagagtg gcgaacggct atggactgaa cggagccgca     1020

gctcagttta gcctcagcga tgtcgatccc ataactgcac aggtgaaaca gatgcctacg     1080

ttggaacagc tgaagtcatg ggtaagaaat aacggcgaag cctaa                     1125


<210>  409
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas7

<400>  409

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala 
    370                 


<210>  410
<211>  2670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas8

<400>  410
atgcaccatc accatcacca tggaaaaatc gaagaaggta aactggtaat ctggattaac       60

ggcgataaag gctataacgg tctcgctgaa gtcggtaaga aattcgagaa agataccgga      120

attaaagtca ccgttgagca tccggataaa ctggaagaga aattcccaca ggttgcggca      180

actggcgatg gccctgacat tatcttctgg gcacacgacc gctttggtgg ctacgctcaa      240

tctggcctgt tggctgaaat caccccggac aaagcgttcc aggacaagct gtatccgttt      300

acctgggatg ccgtacgtta caacggcaag ctgattgctt acccgatcgc tgttgaagcg      360

ttatcgctga tttataacaa agatctgctg ccgaacccgc caaaaacctg ggaagagatc      420

ccggcgctgg ataaagaact gaaagcgaaa ggtaagagcg cgctgatgtt caacctgcaa      480

gaaccgtact tcacctggcc gctgattgct gctgacgggg gttatgcgtt caagtatgaa      540

aacggcaagt acgacattaa agacgtgggc gtggataacg ctggcgcgaa agcgggtctg      600

accttcctgg ttgacctgat taaaaacaaa cacatgaatg cagacaccga ttactccatc      660

gcagaagctg cctttaataa aggcgaaaca gcgatgacca tcaacggccc gtgggcatgg      720

tccaacatcg acaccagcaa agtgaattat ggtgtaacgg tactgccgac cttcaagggt      780

caaccatcca aaccgttcgt tggcgtgctg agcgcaggta ttaacgccgc cagtccgaac      840

aaagagctgg caaaagagtt cctcgaaaac tatctgctga ctgatgaagg tctggaagcg      900

gttaataaag acaaaccgct gggtgccgta gcgctgaagt cttacgagga agagttggcg      960

aaagatccac gtattgccgc cactatggaa aacgcccaga aaggtgaaat catgccgaac     1020

atcccgcaga tgtccgcttt ctggtatgcc gtgcgtactg cggtgatcaa cgccgccagc     1080

ggtcgtcaga ctgtcgatga agccctgaaa gacgcgcaga ctaatgggat cgaggaaaac     1140

ctgtacttcc aatccaatgc aatgaatttg cttattgata actggatccc tgtacgcccg     1200

cgaaacgggg ggaaagtcca aatcataaat ctgcaatcgc tatactgcag tagagatcag     1260

tggcgattaa gtttgccccg tgacgatatg gaactggccg ctttagcact gctggtttgc     1320

attgggcaaa ttatcgcccc ggcaaaagat gacgttgaat ttcgacatcg cataatgaat     1380

ccgctcactg aagatgagtt tcaacaactc atcgcgccgt ggatagatat gttctacctt     1440

aatcacgcag aacatccctt tatgcagacc aaaggtgtca aagcaaatga tgtgactcca     1500

atggaaaaac tgttggctgg ggtaagcggc gcgacgaatt gtgcatttgt caatcaaccg     1560

gggcagggtg aagcattatg tggtggatgc actgcgattg cgttattcaa ccaggcgaat     1620

caggcaccag gttttggtgg tggttttaaa agcggtttac gtggaggaac acctgtaaca     1680

acgttcgtac gtgggatcga tcttcgttca acggtgttac tcaatgtcct cacattacct     1740

cgtcttcaaa aacaatttcc taatgaatca catacggaaa accaacctac ctggattaaa     1800

cctatcaagt ccaatgagtc tatacctgct tcgtcaattg ggtttgtccg tggtctattc     1860

tggcaaccag cgcatattga attatgcgat cccattggga ttggtaaatg ttcttgctgt     1920

ggacaggaaa gcaatttgcg ttataccggt tttcttaagg aaaaatttac ctttacagtt     1980

aatgggctat ggccccatcc gcattcccct tgtctggtaa cagtcaagaa aggggaggtt     2040

gaggaaaaat ttcttgcttt caccacctcc gcaccatcat ggacacaaat cagccgagtt     2100

gtggtagata agattattca aaatgaaaat ggaaatcgcg tggcggcggt tgtgaatcaa     2160

ttcagaaata ttgcgccgca aagtcctctt gaattgatta tggggggata tcgtaataat     2220

caagcatcta ttcttgaacg gcgtcatgat gtgttgatgt ttaatcaggg gtggcaacaa     2280

tacggcaatg tgataaacga aatagtgact gttggtttgg gatataaaac agccttacgc     2340

aaggcgttat atacctttgc agaagggttt aaaaataaag acttcaaagg ggccggagtc     2400

tctgttcatg agactgcaga aaggcatttc tatcgacaga gtgaattatt aattcccgat     2460

gtactggcga atgttaattt ttcccaggct gatgaggtaa tagctgattt acgagacaaa     2520

cttcatcaat tgtgtgaaat gctatttaat caatctgtag ctccctatgc acatcatcct     2580

aaattaataa gcacattagc gcttgcccgc gccacgctat acaaacattt acgggagtta     2640

aaaccgcaag gagggccatc aaatggctga                                      2670


<210>  411
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas8

<400>  411

Met His His His His His His Gly Lys Ile Glu Glu Gly Lys Leu Val 
1               5                   10                  15      


Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly 
            20                  25                  30          


Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro 
        35                  40                  45              


Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly 
    50                  55                  60                  


Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln 
65                  70                  75                  80  


Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys 
                85                  90                  95      


Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile 
            100                 105                 110         


Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp 
        115                 120                 125             


Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp 
    130                 135                 140                 


Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln 
145                 150                 155                 160 


Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala 
                165                 170                 175     


Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp 
            180                 185                 190         


Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys 
        195                 200                 205             


Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala 
    210                 215                 220                 


Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp 
225                 230                 235                 240 


Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro 
                245                 250                 255     


Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala 
            260                 265                 270         


Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu 
        275                 280                 285             


Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp 
    290                 295                 300                 


Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala 
305                 310                 315                 320 


Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu 
                325                 330                 335     


Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg 
            340                 345                 350         


Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala 
        355                 360                 365             


Leu Lys Asp Ala Gln Thr Asn Gly Ile Glu Glu Asn Leu Tyr Phe Gln 
    370                 375                 380                 


Ser Asn Ala Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro 
385                 390                 395                 400 


Arg Asn Gly Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys 
                405                 410                 415     


Ser Arg Asp Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu 
            420                 425                 430         


Ala Ala Leu Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala 
        435                 440                 445             


Lys Asp Asp Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu 
    450                 455                 460                 


Asp Glu Phe Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu 
465                 470                 475                 480 


Asn His Ala Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn 
                485                 490                 495     


Asp Val Thr Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr 
            500                 505                 510         


Asn Cys Ala Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly 
        515                 520                 525             


Gly Cys Thr Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly 
    530                 535                 540                 


Phe Gly Gly Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr 
545                 550                 555                 560 


Thr Phe Val Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val 
                565                 570                 575     


Leu Thr Leu Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr 
            580                 585                 590         


Glu Asn Gln Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile 
        595                 600                 605             


Pro Ala Ser Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala 
    610                 615                 620                 


His Ile Glu Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys 
625                 630                 635                 640 


Gly Gln Glu Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe 
                645                 650                 655     


Thr Phe Thr Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu 
            660                 665                 670         


Val Thr Val Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr 
        675                 680                 685             


Thr Ser Ala Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys 
    690                 695                 700                 


Ile Ile Gln Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln 
705                 710                 715                 720 


Phe Arg Asn Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly 
                725                 730                 735     


Tyr Arg Asn Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu 
            740                 745                 750         


Met Phe Asn Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile 
        755                 760                 765             


Val Thr Val Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr 
    770                 775                 780                 


Thr Phe Ala Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val 
785                 790                 795                 800 


Ser Val His Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu 
                805                 810                 815     


Leu Ile Pro Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu 
            820                 825                 830         


Val Ile Ala Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu 
        835                 840                 845             


Phe Asn Gln Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser 
    850                 855                 860                 


Thr Leu Ala Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu 
865                 870                 875                 880 


Lys Pro Gln Gly Gly Pro Ser Asn Gly 
                885                 


<210>  412
<211>  3369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-NLS-FokI-linker-Cas8

<400>  412
atgcaccatc accatcacca tggaaaaatc gaagaaggta aactggtaat ctggattaac       60

ggcgataaag gctataacgg tctcgctgaa gtcggtaaga aattcgagaa agataccgga      120

attaaagtca ccgttgagca tccggataaa ctggaagaga aattcccaca ggttgcggca      180

actggcgatg gccctgacat tatcttctgg gcacacgacc gctttggtgg ctacgctcaa      240

tctggcctgt tggctgaaat caccccggac aaagcgttcc aggacaagct gtatccgttt      300

acctgggatg ccgtacgtta caacggcaag ctgattgctt acccgatcgc tgttgaagcg      360

ttatcgctga tttataacaa agatctgctg ccgaacccgc caaaaacctg ggaagagatc      420

ccggcgctgg ataaagaact gaaagcgaaa ggtaagagcg cgctgatgtt caacctgcaa      480

gaaccgtact tcacctggcc gctgattgct gctgacgggg gttatgcgtt caagtatgaa      540

aacggcaagt acgacattaa agacgtgggc gtggataacg ctggcgcgaa agcgggtctg      600

accttcctgg ttgacctgat taaaaacaaa cacatgaatg cagacaccga ttactccatc      660

gcagaagctg cctttaataa aggcgaaaca gcgatgacca tcaacggccc gtgggcatgg      720

tccaacatcg acaccagcaa agtgaattat ggtgtaacgg tactgccgac cttcaagggt      780

caaccatcca aaccgttcgt tggcgtgctg agcgcaggta ttaacgccgc cagtccgaac      840

aaagagctgg caaaagagtt cctcgaaaac tatctgctga ctgatgaagg tctggaagcg      900

gttaataaag acaaaccgct gggtgccgta gcgctgaagt cttacgagga agagttggcg      960

aaagatccac gtattgccgc cactatggaa aacgcccaga aaggtgaaat catgccgaac     1020

atcccgcaga tgtccgcttt ctggtatgcc gtgcgtactg cggtgatcaa cgccgccagc     1080

ggtcgtcaga ctgtcgatga agccctgaaa gacgcgcaga ctaatgggat cgaggaaaac     1140

ctgtacttcc aatccaatat gccgaaaaaa aagcgcaaag tgcaactggt taaaagcgaa     1200

ctggaagaga aaaaaagtga actgcgccac aaactgaaat atgtgccgca tgaatatatc     1260

gagctgattg aaattgcacg taatccgacc caggatcgta ttctggaaat gaaagtgatg     1320

gaatttttta tgaaagtgta cggctatcgc ggtgaacatc tgggtggtag ccgtaaaccg     1380

gatggtgcaa tttataccgt tggtagcccg attgattatg gtgttattgt tgataccaaa     1440

gcctatagcg gtggttataa tctgccgatt ggtcaggcag atgaaatgca gcgttatgtg     1500

gaagaaaatc agacccgtaa caaacatatt aatccgaatg aatggtggaa agtttatccg     1560

agcagcgtta ccgagtttaa attcctgttt gttagcggtc acttcaaagg caactataaa     1620

gcacagctga cccgtctgaa tcatattacc aattgtaatg gtgcagttct gagcgttgaa     1680

gaactgctga ttggtggtga aatgattaaa gcaggcaccc tgaccctgga agaagttcgt     1740

cgcaaattta acaatggcga aatcaacttt tcaggcagcg aaacgccggg tacaagtgag     1800

tcagcaactc cagagagcgg cggcagtggt agtagtgggg gatctgggtc atctggtggg     1860

atgaatttgc ttattgataa ctggattcct gtacgcccgc gaaacggggg gaaagtccaa     1920

atcataaatc tgcaatcgct atactgcagt agagatcagt ggcgattaag tttgccccgt     1980

gacgatatgg aactggccgc tttagcactg ctggtttgca ttgggcaaat tatcgccccg     2040

gcaaaagatg acgttgaatt tcgacatcgc ataatgaatc cgctcactga agatgagttt     2100

caacaactca tcgcgccgtg gatagatatg ttctacctta atcacgcaga acatcccttt     2160

atgcagacca aaggtgtcaa agcaaatgat gtgactccaa tggaaaaact gttggctggg     2220

gtaagcggcg cgacgaattg tgcatttgtc aatcaaccgg ggcagggtga agcattatgt     2280

ggtggatgca ctgcgattgc gttattcaac caggcgaatc aggcaccagg ttttggtggt     2340

ggttttaaaa gcggtttacg tggaggaaca cctgtaacaa cgttcgtacg tgggatcgat     2400

cttcgttcaa cggtgttact caatgtcctc acattacctc gtcttcaaaa acaatttcct     2460

aatgaatcac atacggaaaa ccaacctacc tggattaaac ctatcaagtc caatgagtct     2520

atacctgctt cgtcaattgg gtttgtccgt ggtctattct ggcaaccagc gcatattgaa     2580

ttatgcgatc ccattgggat tggtaaatgt tcttgctgtg gacaggaaag caatttgcgt     2640

tataccggtt ttcttaagga aaaatttacc tttacagtta atgggctatg gccccatccg     2700

cattcccctt gtctggtaac agtcaagaaa ggggaggttg aggaaaaatt tcttgctttc     2760

accacctccg caccatcatg gacacaaatc agccgagttg tggtagataa gattattcaa     2820

aatgaaaatg gaaatcgcgt ggcggcggtt gtgaatcaat tcagaaatat tgcgccgcaa     2880

agtcctcttg aattgattat ggggggatat cgtaataatc aagcatctat tcttgaacgg     2940

cgtcatgatg tgttgatgtt taatcagggg tggcaacaat acggcaatgt gataaacgaa     3000

atagtgactg ttggtttggg atataaaaca gccttacgca aggcgttata tacctttgca     3060

gaagggttta aaaataaaga cttcaaaggg gccggagtct ctgttcatga gactgcagaa     3120

aggcatttct atcgacagag tgaattatta attcccgatg tactggcgaa tgttaatttt     3180

tcccaggctg atgaggtaat agctgattta cgagacaaac ttcatcaatt gtgtgaaatg     3240

ctatttaatc aatctgtagc tccctatgca catcatccta aattaataag cacattagcg     3300

cttgcccgcg ccacgctata caaacattta cgggagttaa aaccgcaagg agggccatca     3360

aatggctga                                                             3369


<210>  413
<211>  1122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-NLS-FokI-linker-Cas8

<400>  413

Met His His His His His His Gly Lys Ile Glu Glu Gly Lys Leu Val 
1               5                   10                  15      


Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly 
            20                  25                  30          


Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro 
        35                  40                  45              


Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly 
    50                  55                  60                  


Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln 
65                  70                  75                  80  


Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys 
                85                  90                  95      


Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile 
            100                 105                 110         


Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp 
        115                 120                 125             


Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp 
    130                 135                 140                 


Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln 
145                 150                 155                 160 


Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala 
                165                 170                 175     


Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp 
            180                 185                 190         


Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys 
        195                 200                 205             


Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala 
    210                 215                 220                 


Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp 
225                 230                 235                 240 


Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro 
                245                 250                 255     


Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala 
            260                 265                 270         


Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu 
        275                 280                 285             


Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp 
    290                 295                 300                 


Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala 
305                 310                 315                 320 


Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu 
                325                 330                 335     


Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg 
            340                 345                 350         


Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala 
        355                 360                 365             


Leu Lys Asp Ala Gln Thr Asn Gly Ile Glu Glu Asn Leu Tyr Phe Gln 
    370                 375                 380                 


Ser Asn Met Pro Lys Lys Lys Arg Lys Val Gln Leu Val Lys Ser Glu 
385                 390                 395                 400 


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
                405                 410                 415     


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp 
            420                 425                 430         


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
        435                 440                 445             


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
    450                 455                 460                 


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
465                 470                 475                 480 


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
                485                 490                 495     


Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
            500                 505                 510         


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
        515                 520                 525             


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
    530                 535                 540                 


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
545                 550                 555                 560 


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
                565                 570                 575     


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
            580                 585                 590         


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Gly 
        595                 600                 605             


Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Met Asn Leu Leu 
    610                 615                 620                 


Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly Gly Lys Val Gln 
625                 630                 635                 640 


Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp Gln Trp Arg Leu 
                645                 650                 655     


Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu Ala Leu Leu Val 
            660                 665                 670         


Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp Val Glu Phe Arg 
        675                 680                 685             


His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe Gln Gln Leu Ile 
    690                 695                 700                 


Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala Glu His Pro Phe 
705                 710                 715                 720 


Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr Pro Met Glu Lys 
                725                 730                 735     


Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala Phe Val Asn Gln 
            740                 745                 750         


Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr Ala Ile Ala Leu 
        755                 760                 765             


Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly Gly Phe Lys Ser 
    770                 775                 780                 


Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val Arg Gly Ile Asp 
785                 790                 795                 800 


Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu Pro Arg Leu Gln 
                805                 810                 815     


Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln Pro Thr Trp Ile 
            820                 825                 830         


Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser Ser Ile Gly Phe 
        835                 840                 845             


Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu Leu Cys Asp Pro 
    850                 855                 860                 


Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu Ser Asn Leu Arg 
865                 870                 875                 880 


Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr Val Asn Gly Leu 
                885                 890                 895     


Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val Lys Lys Gly Glu 
            900                 905                 910         


Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala Pro Ser Trp Thr 
        915                 920                 925             


Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln Asn Glu Asn Gly 
    930                 935                 940                 


Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn Ile Ala Pro Gln 
945                 950                 955                 960 


Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn Asn Gln Ala Ser 
                965                 970                 975     


Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn Gln Gly Trp Gln 
            980                 985                 990         


Gln Tyr Gly Asn Val Ile Asn Glu  Ile Val Thr Val Gly  Leu Gly Tyr 
        995                 1000                 1005             


Lys Thr  Ala Leu Arg Lys Ala  Leu Tyr Thr Phe Ala  Glu Gly Phe 
    1010                 1015                 1020             


Lys Asn  Lys Asp Phe Lys Gly  Ala Gly Val Ser Val  His Glu Thr 
    1025                 1030                 1035             


Ala Glu  Arg His Phe Tyr Arg  Gln Ser Glu Leu Leu  Ile Pro Asp 
    1040                 1045                 1050             


Val Leu  Ala Asn Val Asn Phe  Ser Gln Ala Asp Glu  Val Ile Ala 
    1055                 1060                 1065             


Asp Leu  Arg Asp Lys Leu His  Gln Leu Cys Glu Met  Leu Phe Asn 
    1070                 1075                 1080             


Gln Ser  Val Ala Pro Tyr Ala  His His Pro Lys Leu  Ile Ser Thr 
    1085                 1090                 1095             


Leu Ala  Leu Ala Arg Ala Thr  Leu Tyr Lys His Leu  Arg Glu Leu 
    1100                 1105                 1110             


Lys Pro  Gln Gly Gly Pro Ser  Asn Gly 
    1115                 1120         


<210>  414
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas8

<400>  414
atgcccaaga aaaagagaaa agtaggatcg ggcatgaatt tgctcattga taattggatt       60

ccggtgcgcc cccggaacgg tgggaaagtg cagatcatca atttgcaaag tctctactgt      120

tccagggacc agtggagact cagcctgcca cgggatgata tggagctggc ggcgttggct      180

ctgctcgtat gcatcggcca gattattgcg ccagcaaagg atgacgttga attccggcat      240

cggataatga acccccttac tgaagatgag ttccagcagc ttatcgcccc atggatcgac      300

atgttctacc tcaaccacgc cgagcatcct tttatgcaga ccaagggagt caaggcgaat      360

gatgtgactc ccatggagaa gctgctggcc ggtgtatctg gggcgaccaa ctgcgcattc      420

gtgaatcagc ctggacaggg ggaggccctc tgtggaggct gcactgctat agcacttttt      480

aaccaagcta atcaagcccc cggctttggt ggagggttta agagtggatt gagggggggc      540

actcccgtaa ccacttttgt gaggggaatt gatctgaggt ctactgtgtt gctgaacgtc      600

ctcacactcc caaggctcca gaagcagttc ccaaacgaaa gtcataccga aaaccagccc      660

acatggatca agcccatcaa atctaatgag agcataccgg ctagcagtat tggatttgta      720

cggggtctgt tctggcagcc agctcacatc gagctgtgtg atcctattgg gatcggcaag      780

tgctcttgtt gtgggcagga gtccaacctt aggtatactg gatttctgaa agagaagttt      840

acctttacag taaatgggct ctggccccac ccccactcac cttgccttgt gacagtgaaa      900

aagggggaag tcgaggagaa gtttctggcc tttacaactt ctgccccttc ctggactcag      960

atttccagag tggtggtaga taagataatt caaaacgaga atggcaatag agtggccgcc     1020

gtggtgaacc agtttcgcaa catcgcccct cagtcccccc tggagctgat tatgggcggt     1080

tatcggaata accaggccag tatactcgag cgacggcacg atgtcctcat gttcaatcaa     1140

ggttggcagc aatatggcaa tgtgattaac gagatcgtaa ccgtgggcct gggatataag     1200

accgccctgc ggaaggcgtt gtatactttt gcagaaggct ttaagaataa ggattttaag     1260

ggtgccggcg tgagtgtcca tgaaacagct gaacggcact tttatcggca gtccgagctg     1320

ttgataccag acgtgctggc taatgtgaac ttctcacagg ccgacgaagt gatcgctgat     1380

ctgcgggata aactgcacca actgtgcgag atgctgttta atcaaagcgt cgctccttat     1440

gcccaccacc caaagctgat ctccacgctg gccctggcgc gcgccacact ttataaacat     1500

ctccgcgaac tgaaacccca ggggggcccc agcaatggct aa                        1542


<210>  415
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas8

<400>  415

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Asn Leu Leu Ile 
1               5                   10                  15      


Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly Gly Lys Val Gln Ile 
            20                  25                  30          


Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp Gln Trp Arg Leu Ser 
        35                  40                  45              


Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu Ala Leu Leu Val Cys 
    50                  55                  60                  


Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp Val Glu Phe Arg His 
65                  70                  75                  80  


Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe Gln Gln Leu Ile Ala 
                85                  90                  95      


Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala Glu His Pro Phe Met 
            100                 105                 110         


Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr Pro Met Glu Lys Leu 
        115                 120                 125             


Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala Phe Val Asn Gln Pro 
    130                 135                 140                 


Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr Ala Ile Ala Leu Phe 
145                 150                 155                 160 


Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly Gly Phe Lys Ser Gly 
                165                 170                 175     


Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val Arg Gly Ile Asp Leu 
            180                 185                 190         


Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu Pro Arg Leu Gln Lys 
        195                 200                 205             


Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln Pro Thr Trp Ile Lys 
    210                 215                 220                 


Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser Ser Ile Gly Phe Val 
225                 230                 235                 240 


Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu Leu Cys Asp Pro Ile 
                245                 250                 255     


Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu Ser Asn Leu Arg Tyr 
            260                 265                 270         


Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr Val Asn Gly Leu Trp 
        275                 280                 285             


Pro His Pro His Ser Pro Cys Leu Val Thr Val Lys Lys Gly Glu Val 
    290                 295                 300                 


Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala Pro Ser Trp Thr Gln 
305                 310                 315                 320 


Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln Asn Glu Asn Gly Asn 
                325                 330                 335     


Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn Ile Ala Pro Gln Ser 
            340                 345                 350         


Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn Asn Gln Ala Ser Ile 
        355                 360                 365             


Leu Glu Arg Arg His Asp Val Leu Met Phe Asn Gln Gly Trp Gln Gln 
    370                 375                 380                 


Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val Gly Leu Gly Tyr Lys 
385                 390                 395                 400 


Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala Glu Gly Phe Lys Asn 
                405                 410                 415     


Lys Asp Phe Lys Gly Ala Gly Val Ser Val His Glu Thr Ala Glu Arg 
            420                 425                 430         


His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro Asp Val Leu Ala Asn 
        435                 440                 445             


Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala Asp Leu Arg Asp Lys 
    450                 455                 460                 


Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln Ser Val Ala Pro Tyr 
465                 470                 475                 480 


Ala His His Pro Lys Leu Ile Ser Thr Leu Ala Leu Ala Arg Ala Thr 
                485                 490                 495     


Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln Gly Gly Pro Ser Asn 
            500                 505                 510         


Gly 
    


<210>  416
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-HA-FokI-linker-Cas8

<400>  416
atgcccaaga aaaagagaaa agtaggctca ggctatccct atgacgtacc cgactacgcg       60

caattggtca aaagcgaact ggaagagaaa aaatctgagc tcagacacaa gctgaagtat      120

gtgccccatg aatacataga actcatagaa atagctcgaa accccacgca ggaccggatc      180

cttgaaatga aagttatgga gttttttatg aaagtgtatg ggtatcgagg agagcatctt      240

ggtggaagtc ggaaaccgga tggggcaata tacactgttg ggagccccat tgactatggt      300

gtgatagtgg acaccaaggc atacagcggg ggatacaatc tgccgatcgg gcaggcagat      360

gagatgcagc gctatgtgga ggagaatcaa actaggaaca aacatattaa cccaaacgaa      420

tggtggaaag tgtatccctc atctgttacg gagttcaagt tcctttttgt atctggccac      480

tttaaaggaa actataaagc acagctcacg cgacttaacc acatcaccaa ttgtaacggt      540

gctgtactca gtgttgagga actcctgatc ggtggtgaaa tgataaaagc tggaaccttg      600

acattggagg aagtaaggag aaagtttaat aatggtgaga tcaatttcag cggctccgaa      660

acgccgggta catccgagtc cgcgactcct gagtcaggag gcagcggctc ctctggtgga      720

agcggctcaa gtggagggat gaatttgctc attgataatt ggattccggt gcgcccccgg      780

aacggtggga aagtgcagat catcaatttg caaagtctct actgttccag ggaccagtgg      840

agactcagcc tgccacggga tgatatggag ctggcggcgt tggctctgct cgtatgcatc      900

ggccagatta ttgcgccagc aaaggatgac gttgaattcc ggcatcggat aatgaacccc      960

cttactgaag atgagttcca gcagcttatc gccccatgga tcgacatgtt ctacctcaac     1020

cacgccgagc atccttttat gcagaccaag ggagtcaagg cgaatgatgt gactcccatg     1080

gagaagctgc tggccggtgt atctggggcg accaactgcg cattcgtgaa tcagcctgga     1140

cagggggagg ccctctgtgg aggctgcact gctatagcac tttttaacca agctaatcaa     1200

gcccccggct ttggtggagg gtttaagagt ggattgaggg ggggcactcc cgtaaccact     1260

tttgtgaggg gaattgatct gaggtctact gtgttgctga acgtcctcac actcccaagg     1320

ctccagaagc agttcccaaa cgaaagtcat accgaaaacc agcccacatg gatcaagccc     1380

atcaaatcta atgagagcat accggctagc agtattggat ttgtacgggg tctgttctgg     1440

cagccagctc acatcgagct gtgtgatcct attgggatcg gcaagtgctc ttgttgtggg     1500

caggagtcca accttaggta tactggattt ctgaaagaga agtttacctt tacagtaaat     1560

gggctctggc cccaccccca ctcaccttgc cttgtgacag tgaaaaaggg ggaagtcgag     1620

gagaagtttc tggcctttac aacttctgcc ccttcctgga ctcagatttc cagagtggtg     1680

gtagataaga taattcaaaa cgagaatggc aatagagtgg ccgccgtggt gaaccagttt     1740

cgcaacatcg cccctcagtc ccccctggag ctgattatgg gcggttatcg gaataaccag     1800

gccagtatac tcgagcgacg gcacgatgtc ctcatgttca atcaaggttg gcagcaatat     1860

ggcaatgtga ttaacgagat cgtaaccgtg ggcctgggat ataagaccgc cctgcggaag     1920

gcgttgtata cttttgcaga aggctttaag aataaggatt ttaagggtgc cggcgtgagt     1980

gtccatgaaa cagctgaacg gcacttttat cggcagtccg agctgttgat accagacgtg     2040

ctggctaatg tgaacttctc acaggccgac gaagtgatcg ctgatctgcg ggataaactg     2100

caccaactgt gcgagatgct gtttaatcaa agcgtcgctc cttatgccca ccacccaaag     2160

ctgatctcca cgctggccct ggcgcgcgcc acactttata aacatctccg cgaactgaaa     2220

ccccaggggg gccccagcaa tggctaa                                         2247


<210>  417
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-HA-FokI-linker-Cas8

<400>  417

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Tyr Pro Tyr Asp Val 
1               5                   10                  15      


Pro Asp Tyr Ala Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser 
            20                  25                  30          


Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu 
        35                  40                  45              


Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys 
    50                  55                  60                  


Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu 
65                  70                  75                  80  


Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro 
                85                  90                  95      


Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr 
            100                 105                 110         


Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu 
        115                 120                 125             


Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val 
    130                 135                 140                 


Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His 
145                 150                 155                 160 


Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr 
                165                 170                 175     


Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly 
            180                 185                 190         


Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys 
        195                 200                 205             


Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly Ser Glu Thr Pro Gly Thr 
    210                 215                 220                 


Ser Glu Ser Ala Thr Pro Glu Ser Gly Gly Ser Gly Ser Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Ser Ser Gly Gly Met Asn Leu Leu Ile Asp Asn Trp Ile Pro 
                245                 250                 255     


Val Arg Pro Arg Asn Gly Gly Lys Val Gln Ile Ile Asn Leu Gln Ser 
            260                 265                 270         


Leu Tyr Cys Ser Arg Asp Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp 
        275                 280                 285             


Met Glu Leu Ala Ala Leu Ala Leu Leu Val Cys Ile Gly Gln Ile Ile 
    290                 295                 300                 


Ala Pro Ala Lys Asp Asp Val Glu Phe Arg His Arg Ile Met Asn Pro 
305                 310                 315                 320 


Leu Thr Glu Asp Glu Phe Gln Gln Leu Ile Ala Pro Trp Ile Asp Met 
                325                 330                 335     


Phe Tyr Leu Asn His Ala Glu His Pro Phe Met Gln Thr Lys Gly Val 
            340                 345                 350         


Lys Ala Asn Asp Val Thr Pro Met Glu Lys Leu Leu Ala Gly Val Ser 
        355                 360                 365             


Gly Ala Thr Asn Cys Ala Phe Val Asn Gln Pro Gly Gln Gly Glu Ala 
    370                 375                 380                 


Leu Cys Gly Gly Cys Thr Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln 
385                 390                 395                 400 


Ala Pro Gly Phe Gly Gly Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr 
                405                 410                 415     


Pro Val Thr Thr Phe Val Arg Gly Ile Asp Leu Arg Ser Thr Val Leu 
            420                 425                 430         


Leu Asn Val Leu Thr Leu Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu 
        435                 440                 445             


Ser His Thr Glu Asn Gln Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn 
    450                 455                 460                 


Glu Ser Ile Pro Ala Ser Ser Ile Gly Phe Val Arg Gly Leu Phe Trp 
465                 470                 475                 480 


Gln Pro Ala His Ile Glu Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys 
                485                 490                 495     


Ser Cys Cys Gly Gln Glu Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys 
            500                 505                 510         


Glu Lys Phe Thr Phe Thr Val Asn Gly Leu Trp Pro His Pro His Ser 
        515                 520                 525             


Pro Cys Leu Val Thr Val Lys Lys Gly Glu Val Glu Glu Lys Phe Leu 
    530                 535                 540                 


Ala Phe Thr Thr Ser Ala Pro Ser Trp Thr Gln Ile Ser Arg Val Val 
545                 550                 555                 560 


Val Asp Lys Ile Ile Gln Asn Glu Asn Gly Asn Arg Val Ala Ala Val 
                565                 570                 575     


Val Asn Gln Phe Arg Asn Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile 
            580                 585                 590         


Met Gly Gly Tyr Arg Asn Asn Gln Ala Ser Ile Leu Glu Arg Arg His 
        595                 600                 605             


Asp Val Leu Met Phe Asn Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile 
    610                 615                 620                 


Asn Glu Ile Val Thr Val Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys 
625                 630                 635                 640 


Ala Leu Tyr Thr Phe Ala Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly 
                645                 650                 655     


Ala Gly Val Ser Val His Glu Thr Ala Glu Arg His Phe Tyr Arg Gln 
            660                 665                 670         


Ser Glu Leu Leu Ile Pro Asp Val Leu Ala Asn Val Asn Phe Ser Gln 
        675                 680                 685             


Ala Asp Glu Val Ile Ala Asp Leu Arg Asp Lys Leu His Gln Leu Cys 
    690                 695                 700                 


Glu Met Leu Phe Asn Gln Ser Val Ala Pro Tyr Ala His His Pro Lys 
705                 710                 715                 720 


Leu Ile Ser Thr Leu Ala Leu Ala Arg Ala Thr Leu Tyr Lys His Leu 
                725                 730                 735     


Arg Glu Leu Lys Pro Gln Gly Gly Pro Ser Asn Gly 
            740                 745             


<210>  418
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hexahistidine

<400>  418

His His His His His His 
1               5       


<210>  419
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Strep-tag

<400>  419

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  420
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HRV3C (human rhinovirus 3C) protease recognition 
       sequence

<400>  420

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  421
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: nuclear localization signal

<400>  421

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  422
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hemagglutinin

<400>  422

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  423
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: maltose binding protein

<400>  423

Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365         


<210>  424
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: TEV (tobacco etch virus) protease recognition sequence

<400>  424

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  425
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker polypeptide

<400>  425

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly 
            20                  25                  30  


<210>  426
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5-amino acid linker, FokI-Cas8 fusion

<400>  426

Gly Gly Gly Gly Ser 
1               5   


<210>  427
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 8-amino acid linker, FokI-Cas8 fusion

<400>  427

Thr Gly Pro Gly Ala Ala Ala Arg 
1               5               


<210>  428
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 10-amino acid linker, FokI-Cas8 fusion

<400>  428

Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly 
1               5                   10  


<210>  429
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 12-amino acid linker, FokI-Cas8 fusion

<400>  429

Thr Gly Pro Gly Ala Ala Ala Arg Ala Ala Ser Gly 
1               5                   10          


<210>  430
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 15-amino acid linker, FokI-Cas8 fusion

<400>  430

Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Ser 
1               5                   10                  15  


<210>  431
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 16-amino acid linker, FokI-Cas8 fusion

<400>  431

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  432
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 20-amino acid linker, FokI-Cas8 fusion

<400>  432

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210>  433
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 30-amino acid linker, FokI-Cas8 fusion

<400>  433

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly 
            20                  25                  30  


<210>  434
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(J3)

<400>  434
gagttccccg cgccagcggg gataaaccgc cagtgataag tggaatgcca tgtgggctgt       60

cgagttcccc gcgccagcgg ggataaaccg                                        90


<210>  435
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(L3)

<400>  435
gagttccccg cgccagcggg gataaaccga gtggcagata tagcctggtg gttcaggcgg       60

cgagttcccc gcgccagcgg ggataaaccg                                        90


<210>  436
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(J3/L3)

<400>  436
gagttccccg cgccagcggg gataaaccgc cagtgataag tggaatgcca tgtgggctgt       60

cgagttcccc gcgccagcgg ggataaaccg agtggcagat atagcctggt ggttcaggcg      120

gcgagttccc cgcgccagcg gggataaacc g                                     151


<210>  437
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(TRAC)

<400>  437
gagttccccg cgccagcggg gataaaccgg ttgatttgcc tgcattggtg ttacacagtc       60

tgagttcccc gcgccagcgg ggataaaccg taagttgtgt tcttctttgc ctaggccttc      120

aggagttccc cgcgccagcg gggataaacc g                                     151


<210>  438
<211>  7967
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas8

<400>  438
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaact agtaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatgt     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaactaa ggaggtccgc tatgcaccat caccatcacc atggaaaaat     5100

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga     5160

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa     5220

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg     5280

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga     5340

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa     5400

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct     5460

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa     5520

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc     5580

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     5640

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     5700

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     5760

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     5820

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     5880

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     5940

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     6000

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     6060

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     6120

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     6180

agacgcgcag actaatggga tcgaggaaaa cctgtacttc caatccaatg caatgaattt     6240

gcttattgat aactggatcc ctgtacgccc gcgaaacggg gggaaagtcc aaatcataaa     6300

tctgcaatcg ctatactgca gtagagatca gtggcgatta agtttgcccc gtgacgatat     6360

ggaactggcc gctttagcac tgctggtttg cattgggcaa attatcgccc cggcaaaaga     6420

tgacgttgaa tttcgacatc gcataatgaa tccgctcact gaagatgagt ttcaacaact     6480

catcgcgccg tggatagata tgttctacct taatcacgca gaacatccct ttatgcagac     6540

caaaggtgtc aaagcaaatg atgtgactcc aatggaaaaa ctgttggctg gggtaagcgg     6600

cgcgacgaat tgtgcatttg tcaatcaacc ggggcagggt gaagcattat gtggtggatg     6660

cactgcgatt gcgttattca accaggcgaa tcaggcacca ggttttggtg gtggttttaa     6720

aagcggttta cgtggaggaa cacctgtaac aacgttcgta cgtgggatcg atcttcgttc     6780

aacggtgtta ctcaatgtcc tcacattacc tcgtcttcaa aaacaatttc ctaatgaatc     6840

acatacggaa aaccaaccta cctggattaa acctatcaag tccaatgagt ctatacctgc     6900

ttcgtcaatt gggtttgtcc gtggtctatt ctggcaacca gcgcatattg aattatgcga     6960

tcccattggg attggtaaat gttcttgctg tggacaggaa agcaatttgc gttataccgg     7020

ttttcttaag gaaaaattta cctttacagt taatgggcta tggccccatc cgcattcccc     7080

ttgtctggta acagtcaaga aaggggaggt tgaggaaaaa tttcttgctt tcaccacctc     7140

cgcaccatca tggacacaaa tcagccgagt tgtggtagat aagattattc aaaatgaaaa     7200

tggaaatcgc gtggcggcgg ttgtgaatca attcagaaat attgcgccgc aaagtcctct     7260

tgaattgatt atggggggat atcgtaataa tcaagcatct attcttgaac ggcgtcatga     7320

tgtgttgatg tttaatcagg ggtggcaaca atacggcaat gtgataaacg aaatagtgac     7380

tgttggtttg ggatataaaa cagccttacg caaggcgtta tatacctttg cagaagggtt     7440

taaaaataaa gacttcaaag gggccggagt ctctgttcat gagactgcag aaaggcattt     7500

ctatcgacag agtgaattat taattcccga tgtactggcg aatgttaatt tttcccaggc     7560

tgatgaggta atagctgatt tacgagacaa acttcatcaa ttgtgtgaaa tgctatttaa     7620

tcaatctgta gctccctatg cacatcatcc taaattaata agcacattag cgcttgcccg     7680

cgccacgcta tacaaacatt tacgggagtt aaaaccgcaa ggagggccat caaatggctg     7740

ataataacat tggaagtgga taacggatcc gaattcgagc gccgtcgaca agcttgcggc     7800

cgcactcgag caccaccacc accaccactg agatccggct gctaacaaag cccgaaagga     7860

agctgagttg gctgctgcca ccgctgagca ataactagca taaccccttg gggcctctaa     7920

acgggtcttg aggggttttt tgctgaaagg aggaactata tccggat                   7967


<210>  439
<211>  8659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-NLS-Fok1-linker-Cas8

<400>  439
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaact agtaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatgt     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaactaa ggaggtccgc tatgcaccat caccatcacc atggaaaaat     5100

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga     5160

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa     5220

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg     5280

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga     5340

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa     5400

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct     5460

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa     5520

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc     5580

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     5640

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     5700

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     5760

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     5820

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     5880

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     5940

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     6000

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     6060

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     6120

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     6180

agacgcgcag actaatggga tcgaggaaaa cctgtacttc caatccaata tgccgaaaaa     6240

aaagcgcaaa gtgcaactgg ttaaaagcga actggaagag aaaaaaagtg aactgcgcca     6300

caaactgaaa tatgtgccgc atgaatatat cgagctgatt gaaattgcac gtaatccgac     6360

ccaggatcgt attctggaaa tgaaagtgat ggaatttttt atgaaagtgt acggctatcg     6420

cggtgaacat ctgggtggta gccgtaaacc ggatggtgca atttataccg ttggtagccc     6480

gattgattat ggtgttattg ttgataccaa agcctatagc ggtggttata atctgccgat     6540

tggtcaggca gatgaaatgc agcgttatgt ggaagaaaat cagacccgta acaaacatat     6600

taatccgaat gaatggtgga aagtttatcc gagcagcgtt accgagttta aattcctgtt     6660

tgttagcggt cacttcaaag gcaactataa agcacagctg acccgtctga atcatattac     6720

caattgtaat ggtgcagttc tgagcgttga agaactgctg attggtggtg aaatgattaa     6780

agcaggcacc ctgaccctgg aagaagttcg tcgcaaattt aacaatggcg aaatcaactt     6840

ttcaggcagc gaaacgccgg gtacaagtga gtcagcaact ccagagagcg gcggcagtgg     6900

tagtagtggg ggatctgggt catctggtgg gatgaatttg cttattgata actggattcc     6960

tgtacgcccg cgaaacgggg ggaaagtcca aatcataaat ctgcaatcgc tatactgcag     7020

tagagatcag tggcgattaa gtttgccccg tgacgatatg gaactggccg ctttagcact     7080

gctggtttgc attgggcaaa ttatcgcccc ggcaaaagat gacgttgaat ttcgacatcg     7140

cataatgaat ccgctcactg aagatgagtt tcaacaactc atcgcgccgt ggatagatat     7200

gttctacctt aatcacgcag aacatccctt tatgcagacc aaaggtgtca aagcaaatga     7260

tgtgactcca atggaaaaac tgttggctgg ggtaagcggc gcgacgaatt gtgcatttgt     7320

caatcaaccg gggcagggtg aagcattatg tggtggatgc actgcgattg cgttattcaa     7380

ccaggcgaat caggcaccag gttttggtgg tggttttaaa agcggtttac gtggaggaac     7440

acctgtaaca acgttcgtac gtgggatcga tcttcgttca acggtgttac tcaatgtcct     7500

cacattacct cgtcttcaaa aacaatttcc taatgaatca catacggaaa accaacctac     7560

ctggattaaa cctatcaagt ccaatgagtc tatacctgct tcgtcaattg ggtttgtccg     7620

tggtctattc tggcaaccag cgcatattga attatgcgat cccattggga ttggtaaatg     7680

ttcttgctgt ggacaggaaa gcaatttgcg ttataccggt tttcttaagg aaaaatttac     7740

ctttacagtt aatgggctat ggccccatcc gcattcccct tgtctggtaa cagtcaagaa     7800

aggggaggtt gaggaaaaat ttcttgcttt caccacctcc gcaccatcat ggacacaaat     7860

cagccgagtt gtggtagata agattattca aaatgaaaat ggaaatcgcg tggcggcggt     7920

tgtgaatcaa ttcagaaata ttgcgccgca aagtcctctt gaattgatta tggggggata     7980

tcgtaataat caagcatcta ttcttgaacg gcgtcatgat gtgttgatgt ttaatcaggg     8040

gtggcaacaa tacggcaatg tgataaacga aatagtgact gttggtttgg gatataaaac     8100

agccttacgc aaggcgttat atacctttgc agaagggttt aaaaataaag acttcaaagg     8160

ggccggagtc tctgttcatg agactgcaga aaggcatttc tatcgacaga gtgaattatt     8220

aattcccgat gtactggcga atgttaattt ttcccaggct gatgaggtaa tagctgattt     8280

acgagacaaa cttcatcaat tgtgtgaaat gctatttaat caatctgtag ctccctatgc     8340

acatcatcct aaattaataa gcacattagc gcttgcccgc gccacgctat acaaacattt     8400

acgggagtta aaaccgcaag gagggccatc aaatggctga attggaagtg gataacggat     8460

ccgaattcga gcgccgtcga caagcttgcg gccgcactcg agcaccacca ccaccaccac     8520

tgagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag     8580

caataactag cataacccct tggggcctct aaacgggtct tgaggggttt tttgctgaaa     8640

ggaggaacta tatccggat                                                  8659


<210>  440
<211>  6435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: StrepII-HRV3C-Cse2_Cas7_Cas5_Cas6

<400>  440
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg gcaagctgga gccacccgca gttcgaaaag      120

ggtgcacttg aagtcctctt tcagggaccc gggtaccaga tggctgatga aattgatgca      180

atggctttat atcgagcctg gcaacaactg gataatggat catgtgcgca aattagacgt      240

gtttcagaac ctgatgaatt acgcgatatc cctgcgtttt ataggctggt gcaacctttt      300

ggttgggaaa acccacgtca ccagcaggct cttttgcgca tggtgttttg cctgagcgca      360

ggaaagaatg tcatccgaca tcaggacaaa aaatcggagc aaacaacagg tatctcgttg      420

ggaagagctt tagccaatag tggaagaatt aacgagcgcc gtatctttca attaattcgg      480

gctgacagaa cagccgatat ggtccagtta cgtcgattac ttactcacgc cgaacccgta      540

cttgactggc cattaatggc caggatgttg acctggtggg gaaagcgcga acgccagcaa      600

cttctggaag attttgtatt gaccacaaac aaaaatgcgt aaggaaacct ttctatgtct      660

aactttatca atattcatgt tctgatctct cacagccctt catgtctgaa ccgcgacgat      720

atgaacatgc agaaagacgc tattttcggc ggcaaaagac gagtaagaat ttcaagtcaa      780

agccttaaac gtgcgatgcg taaaagtggt tattacgcac aaaatattgg tgaatccagt      840

ctcagaacca ttcatcttgc acaattacgt gatgttcttc ggcaaaaact tggtgaacgt      900

tttgaccaaa aaatcatcga taagacatta gcgctgctct ccggtaaatc agttgatgaa      960

gccgaaaaga tttctgccga tgcggttact ccctgggttg tgggagaaat agcctggttc     1020

tgtgagcagg ttgcaaaagc agaggctgat aatctggatg ataaaaagct gctcaaagtt     1080

cttaaggaag atattgccgc catacgtgtg aatttacagc agggtgttga tattgcgctt     1140

agtggaagaa tggcaaccag cggcatgatg actgagttgg gaaaagttga tggtgcaatg     1200

tccattgcgc atgcgatcac tactcatcag gttgattctg atattgactg gttcaccgct     1260

gtagatgatt tacaggaaca aggttctgca catctgggaa ctcaggaatt ttcatcgggt     1320

gttttttatc gttatgccaa cattaacctc gctcaacttc aggaaaattt aggtggtgcc     1380

tccagggagc aggctctgga aattgcaacc catgttgttc atatgctggc aacagaggtc     1440

cctggagcaa aacagcgtac ttatgccgct tttaaccctg cggatatggt aatggttaat     1500

ttctccgata tgccactttc tatggcaaat gcttttgaaa aagcggttaa agcgaaagat     1560

ggctttttgc aaccgtctat acaggcgttt aatcaatatt gggatcgcgt tgccaatgga     1620

tatggtctga acggagctgc tgcgcaattc agcttatctg atgtagaccc aattactgct     1680

caagttaaac aaatgcctac tttagaacag ttaaaatcct gggttcgtaa taatggcgag     1740

gcgtgaacat gagatcttat ttgatcttgc ggcttgctgg gccaatgcaa gcctgggggc     1800

agccgacctt tgaaggaacg cgacctaccg gaagatttcc gacccgaagc gggttattag     1860

ggctactcgg ggcttgtctt gggatccaac gtgatgatac ttcttcatta caggcgttat     1920

cagagagtgt gcaatttgca gtgcgctgcg atgaactcat tcttgacgat cgtcgtgtgt     1980

ctgtaacggg gttgcgtgat taccatacag tccttggagc gcgagaagat taccgtggtt     2040

tgaaaagtca tgaaacgatt caaacatggc gcgaatattt atgtgatgcc tcctttaccg     2100

tcgctctctg gttaacaccc catgcaacga tggttatctc agaacttgaa aaagcagtat     2160

taaagcctcg gtatacacct tacctggggc ggagaagttg cccactaaca cacccgcttt     2220

ttttggggac atgtcaggca tcggatcctc agaaggcgct attaaattat gagcccgttg     2280

gcggcgatat atatagtgag gaatcagtta cagggcatca tttaaaattt acggcgcgcg     2340

acgaaccgat gatcaccttg cctcgacaat ttgcttcccg agaatggtat gtgattaaag     2400

gaggtatgga tgtatctcag taaagtcatc attgccaggg cctggagcag ggatctttac     2460

caacttcacc agggattatg gcatttattt ccaaacagac cggatgctgc tcgtgatttt     2520

ctttttcatg ttgagaagcg aaacacacca gaaggctgtc atgttttatt gcagtcagcg     2580

caaatgcctg tttcaactgc cgttgcgaca gtcattaaaa ctaaacaggt tgaatttcaa     2640

cttcaggttg gtgttccact ctattttcgg cttcgggcaa atccgatcaa aactattctc     2700

gacaatcaaa agcgcctgga cagtaaaggg aatattaaac gctgtcgggt tccgttaata     2760

aaagaagcag aacaaatcgc gtggttgcaa cgtaaattgg gcaatgcggc gcgcgttgaa     2820

gatgtgcatc ccatatcgga acggccacag tatttttctg gtgatggtaa aagtggaaag     2880

atccaaacgg tttgctttga aggtgtgctc accatcaacg acgcgccagc gttaatagat     2940

cttgtacagc aaggtattgg gccagctaaa tcgatgggat gtggcttgct atctttggct     3000

ccactgtgac tgcaggcggc cgcactcgag tctggtaaag aaaccgctgc tgcgaaattt     3060

gaacgccagc acatggactc gtctactagc gcagcttaat taacctaggc tgctgccacc     3120

gctgagcaat aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg     3180

ctgaaacctc aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg     3240

gtaaaccagc aatagacata agcggctatt taacgaccct gccctgaacc gacgaccggg     3300

tcatcgtggc cggatcttgc ggcccctcgg cttgaacgaa ttgttagaca ttatttgccg     3360

actaccttgg tgatctcgcc tttcacgtag tggacaaatt cttccaactg atctgcgcgc     3420

gaggccaagc gatcttcttc ttgtccaaga taagcctgtc tagcttcaag tatgacgggc     3480

tgatactggg ccggcaggcg ctccattgcc cagtcggcag cgacatcctt cggcgcgatt     3540

ttgccggtta ctgcgctgta ccaaatgcgg gacaacgtaa gcactacatt tcgctcatcg     3600

ccagcccagt cgggcggcga gttccatagc gttaaggttt catttagcgc ctcaaataga     3660

tcctgttcag gaaccggatc aaagagttcc tccgccgctg gacctaccaa ggcaacgcta     3720

tgttctcttg cttttgtcag caagatagcc agatcaatgt cgatcgtggc tggctcgaag     3780

atacctgcaa gaatgtcatt gcgctgccat tctccaaatt gcagttcgcg cttagctgga     3840

taacgccacg gaatgatgtc gtcgtgcaca acaatggtga cttctacagc gcggagaatc     3900

tcgctctctc caggggaagc cgaagtttcc aaaaggtcgt tgatcaaagc tcgccgcgtt     3960

gtttcatcaa gccttacggt caccgtaacc agcaaatcaa tatcactgtg tggcttcagg     4020

ccgccatcca ctgcggagcc gtacaaatgt acggccagca acgtcggttc gagatggcgc     4080

tcgatgacgc caactacctc tgatagttga gtcgatactt cggcgatcac cgcttccctc     4140

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     4200

tacatatttg aatgtattta gaaaaataaa caaatagcta gctcactcgg tcgctacgct     4260

ccgggcgtga gactgcggcg ggcgctgcgg acacatacaa agttacccac agattccgtg     4320

gataagcagg ggactaacat gtgaggcaaa acagcagggc cgcgccggtg gcgtttttcc     4380

ataggctccg ccctcctgcc agagttcaca taaacagacg cttttccggt gcatctgtgg     4440

gagccgtgag gctcaaccat gaatctgaca gtacgggcga aacccgacag gacttaaaga     4500

tccccaccgt ttccggcggg tcgctccctc ttgcgctctc ctgttccgac cctgccgttt     4560

accggatacc tgttccgcct ttctccctta cgggaagtgt ggcgctttct catagctcac     4620

acactggtat ctcggctcgg tgtaggtcgt tcgctccaag ctgggctgta agcaagaact     4680

ccccgttcag cccgactgct gcgccttatc cggtaactgt tcacttgagt ccaacccgga     4740

aaagcacggt aaaacgccac tggcagcagc cattggtaac tgggagttcg cagaggattt     4800

gtttagctaa acacgcggtt gctcttgaag tgtgcgccaa agtccggcta cactggaagg     4860

acagatttgg ttgctgtgct ctgcgaaagc cagttaccac ggttaagcag ttccccaact     4920

gacttaacct tcgatcaaac cacctcccca ggtggttttt tcgtttacag ggcaaaagat     4980

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctactg aaccgctcta     5040

gatttcagtg caatttatct cttcaaatgt agcacctgaa gtcagcccca tacgatataa     5100

gttgtaattc tcatgttagt catgccccgc gcccaccgga aggagctgac tgggttgaag     5160

gctctcaagg gcatcggtcg agatcccggt gcctaatgag tgagctaact tacattaatt     5220

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     5280

atcggccaac gcgcggggag aggcggtttg cgtattgggc gccagggtgg tttttctttt     5340

caccagtgag acgggcaaca gctgattgcc cttcaccgcc tggccctgag agagttgcag     5400

caagcggtcc acgctggttt gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg     5460

cgggatataa catgagctgt cttcggtatc gtcgtatccc actaccgaga tgtccgcacc     5520

aacgcgcagc ccggactcgg taatggcgcg cattgcgccc agcgccatct gatcgttggc     5580

aaccagcatc gcagtgggaa cgatgccctc attcagcatt tgcatggttt gttgaaaacc     5640

ggacatggca ctccagtcgc cttcccgttc cgctatcggc tgaatttgat tgcgagtgag     5700

atatttatgc cagccagcca gacgcagacg cgccgagaca gaacttaatg ggcccgctaa     5760

cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc     5820

ttcatgggag aaaataatac tgttgatggg tgtctggtca gagacatcaa gaaataacgc     5880

cggaacatta gtgcaggcag cttccacagc aatggcatcc tggtcatcca gcggatagtt     5940

aatgatcagc ccactgacgc gttgcgcgag aagattgtgc accgccgctt tacaggcttc     6000

gacgccgctt cgttctacca tcgacaccac cacgctggca cccagttgat cggcgcgaga     6060

tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc agactggagg tggcaacgcc     6120

aatcagcaac gactgtttgc ccgccagttg ttgtgccacg cggttgggaa tgtaattcag     6180

ctccgccatc gccgcttcca ctttttcccg cgttttcgca gaaacgtggc tggcctggtt     6240

caccacgcgg gaaacggtct gataagagac accggcatac tctgcgacat cgtataacgt     6300

tactggtttc acattcacca ccctgaattg actctcttcc gggcgctatc atgccatacc     6360

gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg acgctctccc ttatgcgact     6420

cctgcattag gaaat                                                      6435


<210>  441
<211>  7933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_His6HRV3CCse2_Cas7_Cas5_Cas6

<400>  441
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctaa tttgcttatt gataactgga tccctgtacg cccgcgaaac ggggggaaag     1560

tccaaatcat aaatctgcaa tcgctatact gcagtagaga tcagtggcga ttaagtttgc     1620

cccgtgacga tatggaactg gccgctttag cactgctggt ttgcattggg caaattatcg     1680

ccccggcaaa agatgacgtt gaatttcgac atcgcataat gaatccgctc actgaagatg     1740

agtttcaaca actcatcgcg ccgtggatag atatgttcta ccttaatcac gcagaacatc     1800

cctttatgca gaccaaaggt gtcaaagcaa atgatgtgac tccaatggaa aaactgttgg     1860

ctggggtaag cggcgcgacg aattgtgcat ttgtcaatca accggggcag ggtgaagcat     1920

tatgtggtgg atgcactgcg attgcgttat tcaaccaggc gaatcaggca ccaggttttg     1980

gtggtggttt taaaagcggt ttacgtggag gaacacctgt aacaacgttc gtacgtggga     2040

tcgatcttcg ttcaacggtg ttactcaatg tcctcacatt acctcgtctt caaaaacaat     2100

ttcctaatga atcacatacg gaaaaccaac ctacctggat taaacctatc aagtccaatg     2160

agtctatacc tgcttcgtca attgggtttg tccgtggtct attctggcaa ccagcgcata     2220

ttgaattatg cgatcccatt gggattggta aatgttcttg ctgtggacag gaaagcaatt     2280

tgcgttatac cggttttctt aaggaaaaat ttacctttac agttaatggg ctatggcccc     2340

atccgcattc cccttgtctg gtaacagtca agaaagggga ggttgaggaa aaatttcttg     2400

ctttcaccac ctccgcacca tcatggacac aaatcagccg agttgtggta gataagatta     2460

ttcaaaatga aaatggaaat cgcgtggcgg cggttgtgaa tcaattcaga aatattgcgc     2520

cgcaaagtcc tcttgaattg attatggggg gatatcgtaa taatcaagca tctattcttg     2580

aacggcgtca tgatgtgttg atgtttaatc aggggtggca acaatacggc aatgtgataa     2640

acgaaatagt gactgttggt ttgggatata aaacagcctt acgcaaggcg ttatatacct     2700

ttgcagaagg gtttaaaaat aaagacttca aaggggccgg agtctctgtt catgagactg     2760

cagaaaggca tttctatcga cagagtgaat tattaattcc cgatgtactg gcgaatgtta     2820

atttttccca ggctgatgag gtaatagctg atttacgaga caaacttcat caattgtgtg     2880

aaatgctatt taatcaatct gtagctccct atgcacatca tcctaaatta ataagcacat     2940

tagcgcttgc ccgcgccacg ctatacaaac atttacggga gttaaaaccg caaggagggc     3000

catcaaatgg ctgagcatca ccaccatcat cacggtgcac ttgaagtcct ctttcaggga     3060

cccgggtacc agatggctga tgaaattgat gcaatggctt tatatcgagc ctggcaacaa     3120

ctggataatg gatcatgtgc gcaaattaga cgtgtttcag aacctgatga attacgcgat     3180

atccctgcgt tttataggct ggtgcaacct tttggttggg aaaacccacg tcaccagcag     3240

gctcttttgc gcatggtgtt ttgcctgagc gcaggaaaga atgtcatccg acatcaggac     3300

aaaaaatcgg agcaaacaac aggtatctcg ttgggaagag ctttagccaa tagtggaaga     3360

attaacgagc gccgtatctt tcaattaatt cgggctgaca gaacagccga tatggtccag     3420

ttacgtcgat tacttactca cgccgaaccc gtacttgact ggccattaat ggccaggatg     3480

ttgacctggt ggggaaagcg cgaacgccag caacttctgg aagattttgt attgaccaca     3540

aacaaaaatg cgtaaggaaa cctttctatg tctaacttta tcaatattca tgttctgatc     3600

tctcacagcc cttcatgtct gaaccgcgac gatatgaaca tgcagaaaga cgctattttc     3660

ggcggcaaaa gacgagtaag aatttcaagt caaagcctta aacgtgcgat gcgtaaaagt     3720

ggttattacg cacaaaatat tggtgaatcc agtctcagaa ccattcatct tgcacaatta     3780

cgtgatgttc ttcggcaaaa acttggtgaa cgttttgacc aaaaaatcat cgataagaca     3840

ttagcgctgc tctccggtaa atcagttgat gaagccgaaa agatttctgc cgatgcggtt     3900

actccctggg ttgtgggaga aatagcctgg ttctgtgagc aggttgcaaa agcagaggct     3960

gataatctgg atgataaaaa gctgctcaaa gttcttaagg aagatattgc cgccatacgt     4020

gtgaatttac agcagggtgt tgatattgcg cttagtggaa gaatggcaac cagcggcatg     4080

atgactgagt tgggaaaagt tgatggtgca atgtccattg cgcatgcgat cactactcat     4140

caggttgatt ctgatattga ctggttcacc gctgtagatg atttacagga acaaggttct     4200

gcacatctgg gaactcagga attttcatcg ggtgtttttt atcgttatgc caacattaac     4260

ctcgctcaac ttcaggaaaa tttaggtggt gcctccaggg agcaggctct ggaaattgca     4320

acccatgttg ttcatatgct ggcaacagag gtccctggag caaaacagcg tacttatgcc     4380

gcttttaacc ctgcggatat ggtaatggtt aatttctccg atatgccact ttctatggca     4440

aatgcttttg aaaaagcggt taaagcgaaa gatggctttt tgcaaccgtc tatacaggcg     4500

tttaatcaat attgggatcg cgttgccaat ggatatggtc tgaacggagc tgctgcgcaa     4560

ttcagcttat ctgatgtaga cccaattact gctcaagtta aacaaatgcc tactttagaa     4620

cagttaaaat cctgggttcg taataatggc gaggcgtgaa catgagatct tatttgatct     4680

tgcggcttgc tgggccaatg caagcctggg ggcagccgac ctttgaagga acgcgaccta     4740

ccggaagatt tccgacccga agcgggttat tagggctact cggggcttgt cttgggatcc     4800

aacgtgatga tacttcttca ttacaggcgt tatcagagag tgtgcaattt gcagtgcgct     4860

gcgatgaact cattcttgac gatcgtcgtg tgtctgtaac ggggttgcgt gattaccata     4920

cagtccttgg agcgcgagaa gattaccgtg gtttgaaaag tcatgaaacg attcaaacat     4980

ggcgcgaata tttatgtgat gcctccttta ccgtcgctct ctggttaaca ccccatgcaa     5040

cgatggttat ctcagaactt gaaaaagcag tattaaagcc tcggtataca ccttacctgg     5100

ggcggagaag ttgcccacta acacacccgc tttttttggg gacatgtcag gcatcggatc     5160

ctcagaaggc gctattaaat tatgagcccg ttggcggcga tatatatagt gaggaatcag     5220

ttacagggca tcatttaaaa tttacggcgc gcgacgaacc gatgatcacc ttgcctcgac     5280

aatttgcttc ccgagaatgg tatgtgatta aaggaggtat ggatgtatct cagtaaagtc     5340

atcattgcca gggcctggag cagggatctt taccaacttc accagggatt atggcattta     5400

tttccaaaca gaccggatgc tgctcgtgat tttctttttc atgttgagaa gcgaaacaca     5460

ccagaaggct gtcatgtttt attgcagtca gcgcaaatgc ctgtttcaac tgccgttgcg     5520

acagtcatta aaactaaaca ggttgaattt caacttcagg ttggtgttcc actctatttt     5580

cggcttcggg caaatccgat caaaactatt ctcgacaatc aaaagcgcct ggacagtaaa     5640

gggaatatta aacgctgtcg ggttccgtta ataaaagaag cagaacaaat cgcgtggttg     5700

caacgtaaat tgggcaatgc ggcgcgcgtt gaagatgtgc atcccatatc ggaacggcca     5760

cagtattttt ctggtgatgg taaaagtgga aagatccaaa cggtttgctt tgaaggtgtg     5820

ctcaccatca acgacgcgcc agcgttaata gatcttgtac agcaaggtat tgggccagct     5880

aaatcgatgg gatgtggctt gctatctttg gctccactgt gactgcaggc ggccgcactc     5940

gagtctggta aagaaaccgc tgctgcgaaa tttgaacgcc agcacatgga ctcgtctact     6000

agcgcagctt aattaaccta ggctgctgcc accgctgagc aataactagc ataacccctt     6060

ggggcctcta aacgggtctt gaggggtttt ttgctgaaac ctcaggcatt tgagaagcac     6120

acggtcacac tgcttccggt agtcaataaa ccggtaaacc agcaatagac ataagcggct     6180

atttaacgac cctgccctga accgacgacc gggtcatcgt ggccggatct tgcggcccct     6240

cggcttgaac gaattgttag acattatttg ccgactacct tggtgatctc gcctttcacg     6300

tagtggacaa attcttccaa ctgatctgcg cgcgaggcca agcgatcttc ttcttgtcca     6360

agataagcct gtctagcttc aagtatgacg ggctgatact gggccggcag gcgctccatt     6420

gcccagtcgg cagcgacatc cttcggcgcg attttgccgg ttactgcgct gtaccaaatg     6480

cgggacaacg taagcactac atttcgctca tcgccagccc agtcgggcgg cgagttccat     6540

agcgttaagg tttcatttag cgcctcaaat agatcctgtt caggaaccgg atcaaagagt     6600

tcctccgccg ctggacctac caaggcaacg ctatgttctc ttgcttttgt cagcaagata     6660

gccagatcaa tgtcgatcgt ggctggctcg aagatacctg caagaatgtc attgcgctgc     6720

cattctccaa attgcagttc gcgcttagct ggataacgcc acggaatgat gtcgtcgtgc     6780

acaacaatgg tgacttctac agcgcggaga atctcgctct ctccagggga agccgaagtt     6840

tccaaaaggt cgttgatcaa agctcgccgc gttgtttcat caagccttac ggtcaccgta     6900

accagcaaat caatatcact gtgtggcttc aggccgccat ccactgcgga gccgtacaaa     6960

tgtacggcca gcaacgtcgg ttcgagatgg cgctcgatga cgccaactac ctctgatagt     7020

tgagtcgata cttcggcgat caccgcttcc ctcatactct tcctttttca atattattga     7080

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     7140

aaacaaatag ctagctcact cggtcgctac gctccgggcg tgagactgcg gcgggcgctg     7200

cggacacata caaagttacc cacagattcc gtggataagc aggggactaa catgtgaggc     7260

aaaacagcag ggccgcgccg gtggcgtttt tccataggct ccgccctcct gccagagttc     7320

acataaacag acgcttttcc ggtgcatctg tgggagccgt gaggctcaac catgaatctg     7380

acagtacggg cgaaacccga caggacttaa agatccccac cgtttccggc gggtcgctcc     7440

ctcttgcgct ctcctgttcc gaccctgccg tttaccggat acctgttccg cctttctccc     7500

ttacgggaag tgtggcgctt tctcatagct cacacactgg tatctcggct cggtgtaggt     7560

cgttcgctcc aagctgggct gtaagcaaga actccccgtt cagcccgact gctgcgcctt     7620

atccggtaac tgttcacttg agtccaaccc ggaaaagcac ggtaaaacgc cactggcagc     7680

agccattggt aactgggagt tcgcagagga tttgtttagc taaacacgcg gttgctcttg     7740

aagtgtgcgc caaagtccgg ctacactgga aggacagatt tggttgctgt gctctgcgaa     7800

agccagttac cacggttaag cagttcccca actgacttaa ccttcgatca aaccacctcc     7860

ccaggtggtt ttttcgttta cagggcaaaa gattacgcgc agaaaaaaag gatctcaaga     7920

agatcctttg atc                                                        7933


<210>  442
<211>  8644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-FokI-linker-Cas8_His6HRV3CCse2_Cas7_Cas5_Cas6

<400>  442
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctcc gaaaaaaaag cgcaaagtgg gtggctctca actggttaaa agcgaactgg     1560

aagagaaaaa aagtgaactg cgccacaaac tgaaatatgt gccgcatgaa tatatcgagc     1620

tgattgaaat tgcacgtaat ccgacccagg atcgtattct ggaaatgaaa gtgatggaat     1680

tttttatgaa agtgtacggc tatcgcggtg aacatctggg tggtagccgt aaaccggatg     1740

gtgcaattta taccgttggt agcccgattg attatggtgt tattgttgat accaaagcct     1800

atagcggtgg ttataatctg ccgattggtc aggcagatga aatgcagcgt tatgtggaag     1860

aaaatcagac ccgtaacaaa catattaatc cgaatgaatg gtggaaagtt tatccgagca     1920

gcgttaccga gtttaaattc ctgtttgtta gcggtcactt caaaggcaac tataaagcac     1980

agctgacccg tctgaatcat attaccaatt gtaatggtgc agttctgagc gttgaagaac     2040

tgctgattgg tggtgaaatg attaaagcag gcaccctgac cctggaagaa gttcgtcgca     2100

aatttaacaa tggcgaaatc aacttttcag gcagcgaaac gccgggtaca agtgagtcag     2160

caactccaga gagcggcggc agtggtagta gtgggggatc tgggtcatct ggtgggatga     2220

atttgcttat tgataactgg attcctgtac gcccgcgaaa cggggggaaa gtccaaatca     2280

taaatctgca atcgctatac tgcagtagag atcagtggcg attaagtttg ccccgtgacg     2340

atatggaact ggccgcttta gcactgctgg tttgcattgg gcaaattatc gccccggcaa     2400

aagatgacgt tgaatttcga catcgcataa tgaatccgct cactgaagat gagtttcaac     2460

aactcatcgc gccgtggata gatatgttct accttaatca cgcagaacat ccctttatgc     2520

agaccaaagg tgtcaaagca aatgatgtga ctccaatgga aaaactgttg gctggggtaa     2580

gcggcgcgac gaattgtgca tttgtcaatc aaccggggca gggtgaagca ttatgtggtg     2640

gatgcactgc gattgcgtta ttcaaccagg cgaatcaggc accaggtttt ggtggtggtt     2700

ttaaaagcgg tttacgtgga ggaacacctg taacaacgtt cgtacgtggg atcgatcttc     2760

gttcaacggt gttactcaat gtcctcacat tacctcgtct tcaaaaacaa tttcctaatg     2820

aatcacatac ggaaaaccaa cctacctgga ttaaacctat caagtccaat gagtctatac     2880

ctgcttcgtc aattgggttt gtccgtggtc tattctggca accagcgcat attgaattat     2940

gcgatcccat tgggattggt aaatgttctt gctgtggaca ggaaagcaat ttgcgttata     3000

ccggttttct taaggaaaaa tttaccttta cagttaatgg gctatggccc catccgcatt     3060

ccccttgtct ggtaacagtc aagaaagggg aggttgagga aaaatttctt gctttcacca     3120

cctccgcacc atcatggaca caaatcagcc gagttgtggt agataagatt attcaaaatg     3180

aaaatggaaa tcgcgtggcg gcggttgtga atcaattcag aaatattgcg ccgcaaagtc     3240

ctcttgaatt gattatgggg ggatatcgta ataatcaagc atctattctt gaacggcgtc     3300

atgatgtgtt gatgtttaat caggggtggc aacaatacgg caatgtgata aacgaaatag     3360

tgactgttgg tttgggatat aaaacagcct tacgcaaggc gttatatacc tttgcagaag     3420

ggtttaaaaa taaagacttc aaaggggccg gagtctctgt tcatgagact gcagaaaggc     3480

atttctatcg acagagtgaa ttattaattc ccgatgtact ggcgaatgtt aatttttccc     3540

aggctgatga ggtaatagct gatttacgag acaaacttca tcaattgtgt gaaatgctat     3600

ttaatcaatc tgtagctccc tatgcacatc atcctaaatt aataagcaca ttagcgcttg     3660

cccgcgccac gctatacaaa catttacggg agttaaaacc gcaaggaggg ccatcaaatg     3720

gctgagcatc accaccatca tcacggtgca cttgaagtcc tctttcaggg acccgggtac     3780

cagatggctg atgaaattga tgcaatggct ttatatcgag cctggcaaca actggataat     3840

ggatcatgtg cgcaaattag acgtgtttca gaacctgatg aattacgcga tatccctgcg     3900

ttttataggc tggtgcaacc ttttggttgg gaaaacccac gtcaccagca ggctcttttg     3960

cgcatggtgt tttgcctgag cgcaggaaag aatgtcatcc gacatcagga caaaaaatcg     4020

gagcaaacaa caggtatctc gttgggaaga gctttagcca atagtggaag aattaacgag     4080

cgccgtatct ttcaattaat tcgggctgac agaacagccg atatggtcca gttacgtcga     4140

ttacttactc acgccgaacc cgtacttgac tggccattaa tggccaggat gttgacctgg     4200

tggggaaagc gcgaacgcca gcaacttctg gaagattttg tattgaccac aaacaaaaat     4260

gcgtaaggaa acctttctat gtctaacttt atcaatattc atgttctgat ctctcacagc     4320

ccttcatgtc tgaaccgcga cgatatgaac atgcagaaag acgctatttt cggcggcaaa     4380

agacgagtaa gaatttcaag tcaaagcctt aaacgtgcga tgcgtaaaag tggttattac     4440

gcacaaaata ttggtgaatc cagtctcaga accattcatc ttgcacaatt acgtgatgtt     4500

cttcggcaaa aacttggtga acgttttgac caaaaaatca tcgataagac attagcgctg     4560

ctctccggta aatcagttga tgaagccgaa aagatttctg ccgatgcggt tactccctgg     4620

gttgtgggag aaatagcctg gttctgtgag caggttgcaa aagcagaggc tgataatctg     4680

gatgataaaa agctgctcaa agttcttaag gaagatattg ccgccatacg tgtgaattta     4740

cagcagggtg ttgatattgc gcttagtgga agaatggcaa ccagcggcat gatgactgag     4800

ttgggaaaag ttgatggtgc aatgtccatt gcgcatgcga tcactactca tcaggttgat     4860

tctgatattg actggttcac cgctgtagat gatttacagg aacaaggttc tgcacatctg     4920

ggaactcagg aattttcatc gggtgttttt tatcgttatg ccaacattaa cctcgctcaa     4980

cttcaggaaa atttaggtgg tgcctccagg gagcaggctc tggaaattgc aacccatgtt     5040

gttcatatgc tggcaacaga ggtccctgga gcaaaacagc gtacttatgc cgcttttaac     5100

cctgcggata tggtaatggt taatttctcc gatatgccac tttctatggc aaatgctttt     5160

gaaaaagcgg ttaaagcgaa agatggcttt ttgcaaccgt ctatacaggc gtttaatcaa     5220

tattgggatc gcgttgccaa tggatatggt ctgaacggag ctgctgcgca attcagctta     5280

tctgatgtag acccaattac tgctcaagtt aaacaaatgc ctactttaga acagttaaaa     5340

tcctgggttc gtaataatgg cgaggcgtga acatgagatc ttatttgatc ttgcggcttg     5400

ctgggccaat gcaagcctgg gggcagccga cctttgaagg aacgcgacct accggaagat     5460

ttccgacccg aagcgggtta ttagggctac tcggggcttg tcttgggatc caacgtgatg     5520

atacttcttc attacaggcg ttatcagaga gtgtgcaatt tgcagtgcgc tgcgatgaac     5580

tcattcttga cgatcgtcgt gtgtctgtaa cggggttgcg tgattaccat acagtccttg     5640

gagcgcgaga agattaccgt ggtttgaaaa gtcatgaaac gattcaaaca tggcgcgaat     5700

atttatgtga tgcctccttt accgtcgctc tctggttaac accccatgca acgatggtta     5760

tctcagaact tgaaaaagca gtattaaagc ctcggtatac accttacctg gggcggagaa     5820

gttgcccact aacacacccg ctttttttgg ggacatgtca ggcatcggat cctcagaagg     5880

cgctattaaa ttatgagccc gttggcggcg atatatatag tgaggaatca gttacagggc     5940

atcatttaaa atttacggcg cgcgacgaac cgatgatcac cttgcctcga caatttgctt     6000

cccgagaatg gtatgtgatt aaaggaggta tggatgtatc tcagtaaagt catcattgcc     6060

agggcctgga gcagggatct ttaccaactt caccagggat tatggcattt atttccaaac     6120

agaccggatg ctgctcgtga ttttcttttt catgttgaga agcgaaacac accagaaggc     6180

tgtcatgttt tattgcagtc agcgcaaatg cctgtttcaa ctgccgttgc gacagtcatt     6240

aaaactaaac aggttgaatt tcaacttcag gttggtgttc cactctattt tcggcttcgg     6300

gcaaatccga tcaaaactat tctcgacaat caaaagcgcc tggacagtaa agggaatatt     6360

aaacgctgtc gggttccgtt aataaaagaa gcagaacaaa tcgcgtggtt gcaacgtaaa     6420

ttgggcaatg cggcgcgcgt tgaagatgtg catcccatat cggaacggcc acagtatttt     6480

tctggtgatg gtaaaagtgg aaagatccaa acggtttgct ttgaaggtgt gctcaccatc     6540

aacgacgcgc cagcgttaat agatcttgta cagcaaggta ttgggccagc taaatcgatg     6600

ggatgtggct tgctatcttt ggctccactg tgactgcagg cggccgcact cgagtctggt     6660

aaagaaaccg ctgctgcgaa atttgaacgc cagcacatgg actcgtctac tagcgcagct     6720

taattaacct aggctgctgc caccgctgag caataactag cataacccct tggggcctct     6780

aaacgggtct tgaggggttt tttgctgaaa cctcaggcat ttgagaagca cacggtcaca     6840

ctgcttccgg tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga     6900

ccctgccctg aaccgacgac cgggtcatcg tggccggatc ttgcggcccc tcggcttgaa     6960

cgaattgtta gacattattt gccgactacc ttggtgatct cgcctttcac gtagtggaca     7020

aattcttcca actgatctgc gcgcgaggcc aagcgatctt cttcttgtcc aagataagcc     7080

tgtctagctt caagtatgac gggctgatac tgggccggca ggcgctccat tgcccagtcg     7140

gcagcgacat ccttcggcgc gattttgccg gttactgcgc tgtaccaaat gcgggacaac     7200

gtaagcacta catttcgctc atcgccagcc cagtcgggcg gcgagttcca tagcgttaag     7260

gtttcattta gcgcctcaaa tagatcctgt tcaggaaccg gatcaaagag ttcctccgcc     7320

gctggaccta ccaaggcaac gctatgttct cttgcttttg tcagcaagat agccagatca     7380

atgtcgatcg tggctggctc gaagatacct gcaagaatgt cattgcgctg ccattctcca     7440

aattgcagtt cgcgcttagc tggataacgc cacggaatga tgtcgtcgtg cacaacaatg     7500

gtgacttcta cagcgcggag aatctcgctc tctccagggg aagccgaagt ttccaaaagg     7560

tcgttgatca aagctcgccg cgttgtttca tcaagcctta cggtcaccgt aaccagcaaa     7620

tcaatatcac tgtgtggctt caggccgcca tccactgcgg agccgtacaa atgtacggcc     7680

agcaacgtcg gttcgagatg gcgctcgatg acgccaacta cctctgatag ttgagtcgat     7740

acttcggcga tcaccgcttc cctcatactc ttcctttttc aatattattg aagcatttat     7800

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     7860

gctagctcac tcggtcgcta cgctccgggc gtgagactgc ggcgggcgct gcggacacat     7920

acaaagttac ccacagattc cgtggataag caggggacta acatgtgagg caaaacagca     7980

gggccgcgcc ggtggcgttt ttccataggc tccgccctcc tgccagagtt cacataaaca     8040

gacgcttttc cggtgcatct gtgggagccg tgaggctcaa ccatgaatct gacagtacgg     8100

gcgaaacccg acaggactta aagatcccca ccgtttccgg cgggtcgctc cctcttgcgc     8160

tctcctgttc cgaccctgcc gtttaccgga tacctgttcc gcctttctcc cttacgggaa     8220

gtgtggcgct ttctcatagc tcacacactg gtatctcggc tcggtgtagg tcgttcgctc     8280

caagctgggc tgtaagcaag aactccccgt tcagcccgac tgctgcgcct tatccggtaa     8340

ctgttcactt gagtccaacc cggaaaagca cggtaaaacg ccactggcag cagccattgg     8400

taactgggag ttcgcagagg atttgtttag ctaaacacgc ggttgctctt gaagtgtgcg     8460

ccaaagtccg gctacactgg aaggacagat ttggttgctg tgctctgcga aagccagtta     8520

ccacggttaa gcagttcccc aactgactta accttcgatc aaaccacctc cccaggtggt     8580

tttttcgttt acagggcaaa agattacgcg cagaaaaaaa ggatctcaag aagatccttt     8640

gatc                                                                  8644


<210>  443
<211>  8687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-FokI-linker-Cas8_His6HRV3CCse2_Cas7-NLS_Cas5_Cas6

<400>  443
ttttctactg aaccgctcta gatttcagtg caatttatct cttcaaatgt agcacctgaa       60

gtcagcccca tacgatataa gttgtaattc tcatgttagt catgccccgc gcccaccgga      120

aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag      180

tgagctaact tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt      240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc      300

gccagggtgg tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc      360

tggccctgag agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc      420

tgtttgatgg tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc      480

actaccgaga tgtccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc      540

agcgccatct gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt      600

tgcatggttt gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc      660

tgaatttgat tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca      720

gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc      780

acgcccagtc gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca      840

gagacatcaa gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc      900

tggtcatcca gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc      960

accgccgctt tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca     1020

cccagttgat cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc     1080

agactggagg tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg     1140

cggttgggaa tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca     1200

gaaacgtggc tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac     1260

tctgcgacat cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc     1320

gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg     1380

acgctctccc ttatgcgact cctgcattag gaaattaata cgactcacta taggggaatt     1440

gtgagcggat aacaattccc ctgtagaaat aattttgttt aactttaata aggagatata     1500

ccatggctcc gaaaaaaaag cgcaaagtgg gtggctctca actggttaaa agcgaactgg     1560

aagagaaaaa aagtgaactg cgccacaaac tgaaatatgt gccgcatgaa tatatcgagc     1620

tgattgaaat tgcacgtaat ccgacccagg atcgtattct ggaaatgaaa gtgatggaat     1680

tttttatgaa agtgtacggc tatcgcggtg aacatctggg tggtagccgt aaaccggatg     1740

gtgcaattta taccgttggt agcccgattg attatggtgt tattgttgat accaaagcct     1800

atagcggtgg ttataatctg ccgattggtc aggcagatga aatgcagcgt tatgtggaag     1860

aaaatcagac ccgtaacaaa catattaatc cgaatgaatg gtggaaagtt tatccgagca     1920

gcgttaccga gtttaaattc ctgtttgtta gcggtcactt caaaggcaac tataaagcac     1980

agctgacccg tctgaatcat attaccaatt gtaatggtgc agttctgagc gttgaagaac     2040

tgctgattgg tggtgaaatg attaaagcag gcaccctgac cctggaagaa gttcgtcgca     2100

aatttaacaa tggcgaaatc aacttttcag gcagcgaaac gccgggtaca agtgagtcag     2160

caactccaga gagcggcggc agtggtagta gtgggggatc tgggtcatct ggtgggatga     2220

atttgcttat tgataactgg attcctgtac gcccgcgaaa cggggggaaa gtccaaatca     2280

taaatctgca atcgctatac tgcagtagag atcagtggcg attaagtttg ccccgtgacg     2340

atatggaact ggccgcttta gcactgctgg tttgcattgg gcaaattatc gccccggcaa     2400

aagatgacgt tgaatttcga catcgcataa tgaatccgct cactgaagat gagtttcaac     2460

aactcatcgc gccgtggata gatatgttct accttaatca cgcagaacat ccctttatgc     2520

agaccaaagg tgtcaaagca aatgatgtga ctccaatgga aaaactgttg gctggggtaa     2580

gcggcgcgac gaattgtgca tttgtcaatc aaccggggca gggtgaagca ttatgtggtg     2640

gatgcactgc gattgcgtta ttcaaccagg cgaatcaggc accaggtttt ggtggtggtt     2700

ttaaaagcgg tttacgtgga ggaacacctg taacaacgtt cgtacgtggg atcgatcttc     2760

gttcaacggt gttactcaat gtcctcacat tacctcgtct tcaaaaacaa tttcctaatg     2820

aatcacatac ggaaaaccaa cctacctgga ttaaacctat caagtccaat gagtctatac     2880

ctgcttcgtc aattgggttt gtccgtggtc tattctggca accagcgcat attgaattat     2940

gcgatcccat tgggattggt aaatgttctt gctgtggaca ggaaagcaat ttgcgttata     3000

ccggttttct taaggaaaaa tttaccttta cagttaatgg gctatggccc catccgcatt     3060

ccccttgtct ggtaacagtc aagaaagggg aggttgagga aaaatttctt gctttcacca     3120

cctccgcacc atcatggaca caaatcagcc gagttgtggt agataagatt attcaaaatg     3180

aaaatggaaa tcgcgtggcg gcggttgtga atcaattcag aaatattgcg ccgcaaagtc     3240

ctcttgaatt gattatgggg ggatatcgta ataatcaagc atctattctt gaacggcgtc     3300

atgatgtgtt gatgtttaat caggggtggc aacaatacgg caatgtgata aacgaaatag     3360

tgactgttgg tttgggatat aaaacagcct tacgcaaggc gttatatacc tttgcagaag     3420

ggtttaaaaa taaagacttc aaaggggccg gagtctctgt tcatgagact gcagaaaggc     3480

atttctatcg acagagtgaa ttattaattc ccgatgtact ggcgaatgtt aatttttccc     3540

aggctgatga ggtaatagct gatttacgag acaaacttca tcaattgtgt gaaatgctat     3600

ttaatcaatc tgtagctccc tatgcacatc atcctaaatt aataagcaca ttagcgcttg     3660

cccgcgccac gctatacaaa catttacggg agttaaaacc gcaaggaggg ccatcaaatg     3720

gctgagcatc accaccatca tcacggtgca cttgaagtcc tctttcaggg acccgggtac     3780

cagatggctg atgaaattga tgcaatggct ttatatcgag cctggcaaca actggataat     3840

ggatcatgtg cgcaaattag acgtgtttca gaacctgatg aattacgcga tatccctgcg     3900

ttttataggc tggtgcaacc ttttggttgg gaaaacccac gtcaccagca ggctcttttg     3960

cgcatggtgt tttgcctgag cgcaggaaag aatgtcatcc gacatcagga caaaaaatcg     4020

gagcaaacaa caggtatctc gttgggaaga gctttagcca atagtggaag aattaacgag     4080

cgccgtatct ttcaattaat tcgggctgac agaacagccg atatggtcca gttacgtcga     4140

ttacttactc acgccgaacc cgtacttgac tggccattaa tggccaggat gttgacctgg     4200

tggggaaagc gcgaacgcca gcaacttctg gaagattttg tattgaccac aaacaaaaat     4260

gcgtaaggaa acctttctat gtctaacttt atcaatattc atgttctgat ctctcacagc     4320

ccttcatgtc tgaaccgcga cgatatgaac atgcagaaag acgctatttt cggcggcaaa     4380

agacgagtaa gaatttcaag tcaaagcctt aaacgtgcga tgcgtaaaag tggttattac     4440

gcacaaaata ttggtgaatc cagtctcaga accattcatc ttgcacaatt acgtgatgtt     4500

cttcggcaaa aacttggtga acgttttgac caaaaaatca tcgataagac attagcgctg     4560

ctctccggta aatcagttga tgaagccgaa aagatttctg ccgatgcggt tactccctgg     4620

gttgtgggag aaatagcctg gttctgtgag caggttgcaa aagcagaggc tgataatctg     4680

gatgataaaa agctgctcaa agttcttaag gaagatattg ccgccatacg tgtgaattta     4740

cagcagggtg ttgatattgc gcttagtgga agaatggcaa ccagcggcat gatgactgag     4800

ttgggaaaag ttgatggtgc aatgtccatt gcgcatgcga tcactactca tcaggttgat     4860

tctgatattg actggttcac cgctgtagat gatttacagg aacaaggttc tgcacatctg     4920

ggaactcagg aattttcatc gggtgttttt tatcgttatg ccaacattaa cctcgctcaa     4980

cttcaggaaa atttaggtgg tgcctccagg gagcaggctc tggaaattgc aacccatgtt     5040

gttcatatgc tggcaacaga ggtccctgga gcaaaacagc gtacttatgc cgcttttaac     5100

cctgcggata tggtaatggt taatttctcc gatatgccac tttctatggc aaatgctttt     5160

gaaaaagcgg ttaaagcgaa agatggcttt ttgcaaccgt ctatacaggc gtttaatcaa     5220

tattgggatc gcgttgccaa tggatatggt ctgaacggag ctgctgcgca attcagctta     5280

tctgatgtag acccaattac tgctcaagtt aaacaaatgc ctactttaga acagttaaaa     5340

tcctgggttc gtaataatgg cgaggcgggc ggtagcccaa agaaaaaacg taaggtttga     5400

taaaggaggt atataatgag atcttatttg atcttgcggc ttgctgggcc aatgcaagcc     5460

tgggggcagc cgacctttga aggaacgcga cctaccggaa gatttccgac ccgaagcggg     5520

ttattagggc tactcggggc ttgtcttggg atccaacgtg atgatacttc ttcattacag     5580

gcgttatcag agagtgtgca atttgcagtg cgctgcgatg aactcattct tgacgatcgt     5640

cgtgtgtctg taacggggtt gcgtgattac catacagtcc ttggagcgcg agaagattac     5700

cgtggtttga aaagtcatga aacgattcaa acatggcgcg aatatttatg tgatgcctcc     5760

tttaccgtcg ctctctggtt aacaccccat gcaacgatgg ttatctcaga acttgaaaaa     5820

gcagtattaa agcctcggta tacaccttac ctggggcgga gaagttgccc actaacacac     5880

ccgctttttt tggggacatg tcaggcatcg gatcctcaga aggcgctatt aaattatgag     5940

cccgttggcg gcgatatata tagtgaggaa tcagttacag ggcatcattt aaaatttacg     6000

gcgcgcgacg aaccgatgat caccttgcct cgacaatttg cttcccgaga atggtatgtg     6060

attaaaggag gtatggatgt atctcagtaa agtcatcatt gccagggcct ggagcaggga     6120

tctttaccaa cttcaccagg gattatggca tttatttcca aacagaccgg atgctgctcg     6180

tgattttctt tttcatgttg agaagcgaaa cacaccagaa ggctgtcatg ttttattgca     6240

gtcagcgcaa atgcctgttt caactgccgt tgcgacagtc attaaaacta aacaggttga     6300

atttcaactt caggttggtg ttccactcta ttttcggctt cgggcaaatc cgatcaaaac     6360

tattctcgac aatcaaaagc gcctggacag taaagggaat attaaacgct gtcgggttcc     6420

gttaataaaa gaagcagaac aaatcgcgtg gttgcaacgt aaattgggca atgcggcgcg     6480

cgttgaagat gtgcatccca tatcggaacg gccacagtat ttttctggtg atggtaaaag     6540

tggaaagatc caaacggttt gctttgaagg tgtgctcacc atcaacgacg cgccagcgtt     6600

aatagatctt gtacagcaag gtattgggcc agctaaatcg atgggatgtg gcttgctatc     6660

tttggctcca ctgtgactgc aggcggccgc actcgagtct ggtaaagaaa ccgctgctgc     6720

gaaatttgaa cgccagcaca tggactcgtc tactagcgca gcttaattaa cctaggctgc     6780

tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg tcttgagggg     6840

ttttttgctg aaacctcagg catttgagaa gcacacggtc acactgcttc cggtagtcaa     6900

taaaccggta aaccagcaat agacataagc ggctatttaa cgaccctgcc ctgaaccgac     6960

gaccgggtca tcgtggccgg atcttgcggc ccctcggctt gaacgaattg ttagacatta     7020

tttgccgact accttggtga tctcgccttt cacgtagtgg acaaattctt ccaactgatc     7080

tgcgcgcgag gccaagcgat cttcttcttg tccaagataa gcctgtctag cttcaagtat     7140

gacgggctga tactgggccg gcaggcgctc cattgcccag tcggcagcga catccttcgg     7200

cgcgattttg ccggttactg cgctgtacca aatgcgggac aacgtaagca ctacatttcg     7260

ctcatcgcca gcccagtcgg gcggcgagtt ccatagcgtt aaggtttcat ttagcgcctc     7320

aaatagatcc tgttcaggaa ccggatcaaa gagttcctcc gccgctggac ctaccaaggc     7380

aacgctatgt tctcttgctt ttgtcagcaa gatagccaga tcaatgtcga tcgtggctgg     7440

ctcgaagata cctgcaagaa tgtcattgcg ctgccattct ccaaattgca gttcgcgctt     7500

agctggataa cgccacggaa tgatgtcgtc gtgcacaaca atggtgactt ctacagcgcg     7560

gagaatctcg ctctctccag gggaagccga agtttccaaa aggtcgttga tcaaagctcg     7620

ccgcgttgtt tcatcaagcc ttacggtcac cgtaaccagc aaatcaatat cactgtgtgg     7680

cttcaggccg ccatccactg cggagccgta caaatgtacg gccagcaacg tcggttcgag     7740

atggcgctcg atgacgccaa ctacctctga tagttgagtc gatacttcgg cgatcaccgc     7800

ttccctcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     7860

gagcggatac atatttgaat gtatttagaa aaataaacaa atagctagct cactcggtcg     7920

ctacgctccg ggcgtgagac tgcggcgggc gctgcggaca catacaaagt tacccacaga     7980

ttccgtggat aagcagggga ctaacatgtg aggcaaaaca gcagggccgc gccggtggcg     8040

tttttccata ggctccgccc tcctgccaga gttcacataa acagacgctt ttccggtgca     8100

tctgtgggag ccgtgaggct caaccatgaa tctgacagta cgggcgaaac ccgacaggac     8160

ttaaagatcc ccaccgtttc cggcgggtcg ctccctcttg cgctctcctg ttccgaccct     8220

gccgtttacc ggatacctgt tccgcctttc tcccttacgg gaagtgtggc gctttctcat     8280

agctcacaca ctggtatctc ggctcggtgt aggtcgttcg ctccaagctg ggctgtaagc     8340

aagaactccc cgttcagccc gactgctgcg ccttatccgg taactgttca cttgagtcca     8400

acccggaaaa gcacggtaaa acgccactgg cagcagccat tggtaactgg gagttcgcag     8460

aggatttgtt tagctaaaca cgcggttgct cttgaagtgt gcgccaaagt ccggctacac     8520

tggaaggaca gatttggttg ctgtgctctg cgaaagccag ttaccacggt taagcagttc     8580

cccaactgac ttaaccttcg atcaaaccac ctccccaggt ggttttttcg tttacagggc     8640

aaaagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatc                   8687


<210>  444
<211>  3736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(J3)

<400>  444
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccgccag tgataagtgg aatgccatgt gggctgtcga gttccccgcg ccagcgggga      180

taaaccggag ctcgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt      240

gaggggtttt ttgctgaaac ctcaggcatt tgagaagcac acggtcacac tgcttccggt      300

agtcaataaa ccggtaaacc agcaatagac ataagcggct atttaacgac cctgccctga      360

accgacgacc gggtcgaatt tgctttcgaa tttctgccat tcatccgctt attatcactt      420

attcaggcgt agcaaccagg cgtttaaggg caccaataac tgccttaaaa aaattacgcc      480

ccgccctgcc actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag      540

ccatcacaaa cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc      600

gtataatatt tgcccatagt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt      660

aaatcaaaac tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata      720

aaccctttag ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg      780

tgtagaaact gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa cgtttcagtt      840

tgctcatgga aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct      900

ttcattgcca tacggaactc cggatgagca ttcatcaggc gggcaagaat gtgaataaag      960

gccggataaa acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc     1020

tgaacggtct ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta     1080

cgatgccatt gggatatatc aacggtggta tatccagtga tttttttctc cattttagct     1140

tccttagctc ctgaaaatct cgataactca aaaaatacgc ccggtagtga tcttatttca     1200

ttatggtgaa agttggaacc tcttacgtgc cgatcaacgt ctcattttcg ccaaaagttg     1260

gcccagggct tcccggtatc aacagggaca ccaggattta tttattctgc gaagtgatct     1320

tccgtcacag gtatttattc ggcgcaaagt gcgtcgggtg atgctgccaa cttactgatt     1380

tagtgtatga tggtgttttt gaggtgctcc agtggcttct gtttctatca gctgtccctc     1440

ctgttcagct actgacgggg tggtgcgtaa cggcaaaagc accgccggac atcagcgcta     1500

gcggagtgta tactggctta ctatgttggc actgatgagg gtgtcagtga agtgcttcat     1560

gtggcaggag aaaaaaggct gcaccggtgc gtcagcagaa tatgtgatac aggatatatt     1620

ccgcttcctc gctcactgac tcgctacgct cggtcgttcg actgcggcga gcggaaatgg     1680

cttacgaacg gggcggagat ttcctggaag atgccaggaa gatacttaac agggaagtga     1740

gagggccgcg gcaaagccgt ttttccatag gctccgcccc cctgacaagc atcacgaaat     1800

ctgacgctca aatcagtggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     1860

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg     1920

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg     1980

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg     2040

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac     2100

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa     2160

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag     2220

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga     2280

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct     2340

agatttcagt gcaatttatc tcttcaaatg tagcacctga agtcagcccc atacgatata     2400

agttgtaatt ctcatgttag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa     2460

ggctctcaag ggcatcggtc gagatcccgg tgcctaatga gtgagctaac ttacattaat     2520

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     2580

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt     2640

tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca     2700

gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg     2760

gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag atgtccgcac     2820

caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg     2880

caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac     2940

cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga     3000

gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta     3060

acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt     3120

cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg     3180

ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt     3240

taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt     3300

cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag     3360

atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc     3420

caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca     3480

gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt     3540

tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg     3600

ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac     3660

cgcgaaaggt tttgcgccat tcgatggtgt ccgggatctc gacgctctcc cttatgcgac     3720

tcctgcatta ggaaat                                                     3736


<210>  445
<211>  3736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(L3)

<400>  445
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccgagtg gcagatatag cctggtggtt caggcggcga gttccccgcg ccagcgggga      180

taaaccggag ctcgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt      240

gaggggtttt ttgctgaaac ctcaggcatt tgagaagcac acggtcacac tgcttccggt      300

agtcaataaa ccggtaaacc agcaatagac ataagcggct atttaacgac cctgccctga      360

accgacgacc gggtcgaatt tgctttcgaa tttctgccat tcatccgctt attatcactt      420

attcaggcgt agcaaccagg cgtttaaggg caccaataac tgccttaaaa aaattacgcc      480

ccgccctgcc actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag      540

ccatcacaaa cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc      600

gtataatatt tgcccatagt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt      660

aaatcaaaac tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata      720

aaccctttag ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg      780

tgtagaaact gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa cgtttcagtt      840

tgctcatgga aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct      900

ttcattgcca tacggaactc cggatgagca ttcatcaggc gggcaagaat gtgaataaag      960

gccggataaa acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc     1020

tgaacggtct ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta     1080

cgatgccatt gggatatatc aacggtggta tatccagtga tttttttctc cattttagct     1140

tccttagctc ctgaaaatct cgataactca aaaaatacgc ccggtagtga tcttatttca     1200

ttatggtgaa agttggaacc tcttacgtgc cgatcaacgt ctcattttcg ccaaaagttg     1260

gcccagggct tcccggtatc aacagggaca ccaggattta tttattctgc gaagtgatct     1320

tccgtcacag gtatttattc ggcgcaaagt gcgtcgggtg atgctgccaa cttactgatt     1380

tagtgtatga tggtgttttt gaggtgctcc agtggcttct gtttctatca gctgtccctc     1440

ctgttcagct actgacgggg tggtgcgtaa cggcaaaagc accgccggac atcagcgcta     1500

gcggagtgta tactggctta ctatgttggc actgatgagg gtgtcagtga agtgcttcat     1560

gtggcaggag aaaaaaggct gcaccggtgc gtcagcagaa tatgtgatac aggatatatt     1620

ccgcttcctc gctcactgac tcgctacgct cggtcgttcg actgcggcga gcggaaatgg     1680

cttacgaacg gggcggagat ttcctggaag atgccaggaa gatacttaac agggaagtga     1740

gagggccgcg gcaaagccgt ttttccatag gctccgcccc cctgacaagc atcacgaaat     1800

ctgacgctca aatcagtggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     1860

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg     1920

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg     1980

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg     2040

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac     2100

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa     2160

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag     2220

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga     2280

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct     2340

agatttcagt gcaatttatc tcttcaaatg tagcacctga agtcagcccc atacgatata     2400

agttgtaatt ctcatgttag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa     2460

ggctctcaag ggcatcggtc gagatcccgg tgcctaatga gtgagctaac ttacattaat     2520

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     2580

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt     2640

tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca     2700

gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg     2760

gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag atgtccgcac     2820

caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg     2880

caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac     2940

cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga     3000

gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta     3060

acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt     3120

cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg     3180

ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt     3240

taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt     3300

cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag     3360

atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc     3420

caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca     3480

gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt     3540

tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg     3600

ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac     3660

cgcgaaaggt tttgcgccat tcgatggtgt ccgggatctc gacgctctcc cttatgcgac     3720

tcctgcatta ggaaat                                                     3736


<210>  446
<211>  3797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(J3/L3)

<400>  446
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccgccag tgataagtgg aatgccatgt gggctgtcga gttccccgcg ccagcgggga      180

taaaccgagt ggcagatata gcctggtggt tcaggcggcg agttccccgc gccagcgggg      240

ataaaccgga gctcgctgag caataactag cataacccct tggggcctct aaacgggtct      300

tgaggggttt tttgctgaaa cctcaggcat ttgagaagca cacggtcaca ctgcttccgg      360

tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga ccctgccctg      420

aaccgacgac cgggtcgaat ttgctttcga atttctgcca ttcatccgct tattatcact      480

tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa aaaattacgc      540

cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc cgacatggaa      600

gccatcacaa acggcatgat gaacctgaat cgccagcggc atcagcacct tgtcgccttg      660

cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat tggccacgtt      720

taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca tattctcaat      780

aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt gcgaatatat      840

gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa acgtttcagt      900

ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca gctcaccgtc      960

tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa tgtgaataaa     1020

ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg taatatccag     1080

ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa aatgttcttt     1140

acgatgccat tgggatatat caacggtggt atatccagtg atttttttct ccattttagc     1200

ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg atcttatttc     1260

attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc gccaaaagtt     1320

ggcccagggc ttcccggtat caacagggac accaggattt atttattctg cgaagtgatc     1380

ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca acttactgat     1440

ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc agctgtccct     1500

cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga catcagcgct     1560

agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg aagtgcttca     1620

tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata caggatatat     1680

tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg agcggaaatg     1740

gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa cagggaagtg     1800

agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag catcacgaaa     1860

tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac caggcgtttc     1920

ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg gtgtcattcc     1980

gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg taggcagttc     2040

gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc gccttatccg     2100

gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg gcagcagcca     2160

ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg ctaaactgaa     2220

aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa agagttggta     2280

gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc agagcaagag     2340

attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat aaaatatttc     2400

tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc catacgatat     2460

aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg actgggttga     2520

aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa cttacattaa     2580

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     2640

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt ggtttttctt     2700

ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg agagagttgc     2760

agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat ggtggttaac     2820

ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga gatgtccgca     2880

ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat ctgatcgttg     2940

gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt ttgttgaaaa     3000

ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg attgcgagtg     3060

agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa tgggcccgct     3120

aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag tcgcgtaccg     3180

tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc aagaaataac     3240

gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc cagcggatag     3300

ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc tttacaggct     3360

tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg atcggcgcga     3420

gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga ggtggcaacg     3480

ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg aatgtaattc     3540

agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg gctggcctgg     3600

ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac atcgtataac     3660

gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta tcatgccata     3720

ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc ccttatgcga     3780

ctcctgcatt aggaaat                                                    3797


<210>  447
<211>  3797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(TRAC)

<400>  447
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggctagcgag ttccccgcgc cagcggggat      120

aaaccggttg atttgcctgc attggtgtta cacagtctga gttccccgcg ccagcgggga      180

taaaccgtaa gttgtgttct tctttgccta ggccttcagg agttccccgc gccagcgggg      240

ataaaccgga gctcgctgag caataactag cataacccct tggggcctct aaacgggtct      300

tgaggggttt tttgctgaaa cctcaggcat ttgagaagca cacggtcaca ctgcttccgg      360

tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga ccctgccctg      420

aaccgacgac cgggtcgaat ttgctttcga atttctgcca ttcatccgct tattatcact      480

tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa aaaattacgc      540

cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc cgacatggaa      600

gccatcacaa acggcatgat gaacctgaat cgccagcggc atcagcacct tgtcgccttg      660

cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat tggccacgtt      720

taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca tattctcaat      780

aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt gcgaatatat      840

gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa acgtttcagt      900

ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca gctcaccgtc      960

tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa tgtgaataaa     1020

ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg taatatccag     1080

ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa aatgttcttt     1140

acgatgccat tgggatatat caacggtggt atatccagtg atttttttct ccattttagc     1200

ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg atcttatttc     1260

attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc gccaaaagtt     1320

ggcccagggc ttcccggtat caacagggac accaggattt atttattctg cgaagtgatc     1380

ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca acttactgat     1440

ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc agctgtccct     1500

cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga catcagcgct     1560

agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg aagtgcttca     1620

tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata caggatatat     1680

tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg agcggaaatg     1740

gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa cagggaagtg     1800

agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag catcacgaaa     1860

tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac caggcgtttc     1920

ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg gtgtcattcc     1980

gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg taggcagttc     2040

gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc gccttatccg     2100

gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg gcagcagcca     2160

ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg ctaaactgaa     2220

aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa agagttggta     2280

gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc agagcaagag     2340

attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat aaaatatttc     2400

tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc catacgatat     2460

aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg actgggttga     2520

aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa cttacattaa     2580

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     2640

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt ggtttttctt     2700

ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg agagagttgc     2760

agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat ggtggttaac     2820

ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga gatgtccgca     2880

ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat ctgatcgttg     2940

gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt ttgttgaaaa     3000

ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg attgcgagtg     3060

agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa tgggcccgct     3120

aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag tcgcgtaccg     3180

tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc aagaaataac     3240

gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc cagcggatag     3300

ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc tttacaggct     3360

tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg atcggcgcga     3420

gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga ggtggcaacg     3480

ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg aatgtaattc     3540

agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg gctggcctgg     3600

ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac atcgtataac     3660

gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta tcatgccata     3720

ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc ccttatgcga     3780

ctcctgcatt aggaaat                                                    3797


<210>  448
<211>  5974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cse2

<400>  448
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc gattacaaag      960

atcacgatgg ggactacaag gatcacgata ttgactataa ggacgacgat gacaagggat     1020

cgggcatggc cgacgagatt gacgcaatgg cactttaccg ggcctggcag cagttggata     1080

atggttcatg tgcccagatt cgcagagtta gtgaacctga cgaactgaga gatatccccg     1140

cgttttacag acttgtccaa ccgttcggat gggagaaccc acggcaccaa caagcactcc     1200

ttcgaatggt cttctgtttg tccgcaggaa aaaatgtaat cagacaccaa gacaaaaaga     1260

gcgagcaaac cacaggtatc agcctgggca gggcacttgc caactctggg cggatcaacg     1320

aaaggagaat ttttcagctg atacgcgctg atcggactgc ggacatggtg cagctgcgca     1380

gactccttac tcatgccgaa cctgtcctgg attggcccct gatggcacgc atgctgactt     1440

ggtggggaaa gagagaaaga cagcaactgc ttgaagactt cgtgctcact acaaataaga     1500

atgcctaata atctagaggg ccctattcta tagtgtcacc taaatgctag agctcgctga     1560

tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct     1620

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     1680

tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     1740

ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct     1800

gaggcggaaa gaaccagctg gggctctagg gggtatcccc acgcgccctg tagcggcgca     1860

ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta     1920

gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt     1980

caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac     2040

cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt     2100

tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga     2160

acaacactca accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg     2220

gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaatta attctgtgga     2280

atgtgtgtca gttagggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa     2340

gcatgcatct caattagtca gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca     2400

gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc ctaactccgc     2460

ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt     2520

tttttattta tgcagaggcc gaggccgcct ctgcctctga gctattccag aagtagtgag     2580

gaggcttttt tggaggccta ggcttttgca aaaagctccc gggagcttgt atatccattt     2640

tcggatctga tcaagagaca ggatgaggat cgtttcgcat gattgaacaa gatggattgc     2700

acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga     2760

caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt     2820

ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca gcgcggctat     2880

cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg     2940

gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg     3000

ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc     3060

cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga     3120

tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag     3180

ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc     3240

atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg     3300

actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata     3360

ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg     3420

ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tgagcgggac     3480

tctggggttc gaaatgaccg accaagcgac gcccaacctg ccatcacgag atttcgattc     3540

caccgccgcc ttctatgaaa ggttgggctt cggaatcgtt ttccgggacg ccggctggat     3600

gatcctccag cgcggggatc tcatgctgga gttcttcgcc caccccaact tgtttattgc     3660

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     3720

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctgtat     3780

accgtcgacc tctagctaga gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa     3840

ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg     3900

gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca     3960

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     4020

tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     4080

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     4140

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     4200

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     4260

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     4320

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     4380

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     4440

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     4500

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     4560

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     4620

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     4680

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     4740

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     4800

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     4860

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     4920

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     4980

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     5040

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     5100

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     5160

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     5220

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     5280

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     5340

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     5400

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     5460

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     5520

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     5580

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat     5640

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     5700

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt     5760

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     5820

gaaatgttga atactcatac tcttcctttt tcattattat tgaagcattt atcagggtta     5880

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     5940

gcgcacattt ccccgaaaag tgccacctga cgtc                                 5974


<210>  449
<211>  6091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas5

<400>  449
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc atgcggagct      960

atctcatcct gagactggcc ggaccaatgc aggcctgggg acagcctacc ttcgaaggta     1020

cacgccccac aggccgcttt cctaccagga gcggcctgct gggcctgctt ggcgcttgtc     1080

ttgggatcca gcgcgatgat actagctccc tgcaagcact gtcagagagc gtgcagtttg     1140

ccgtaagatg cgacgaactg atccttgatg ataggcgggt cagtgtcact ggtctccggg     1200

actaccacac ggtgctgggg gcccgggagg attatagggg cctgaaaagt cacgagacga     1260

ttcaaacctg gcgcgaatat ctgtgcgatg ccagcttcac cgtggccctg tggctgactc     1320

cacatgccac tatggtcatc agtgaactgg aaaaggctgt tcttaagcct cgatatactc     1380

cgtatctggg ccgccggagt tgtccactta cacacccact tttcctcggc acctgccagg     1440

ccagcgaccc tcaaaaggcc cttctgaatt acgagccagt tggcggtgac atatacagcg     1500

aagagtccgt gacgggacac catcttaagt tcaccgctcg ggacgagccc atgattaccc     1560

tcccacggca gttcgcatca agggagtggt acgtcataaa ggggggcatg gatgtgagtc     1620

agtaataatc tagagggccc tattctatag tgtcacctaa atgctagagc tcgctgatca     1680

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     1740

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     1800

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     1860

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     1920

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     1980

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2040

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2100

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     2160

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2220

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     2280

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     2340

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     2400

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     2460

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     2520

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     2580

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     2640

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     2700

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     2760

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     2820

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     2880

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     2940

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     3000

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     3060

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     3120

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     3180

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     3240

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     3300

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     3360

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     3420

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     3480

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     3540

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     3600

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     3660

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     3720

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     3780

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3840

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     3900

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     3960

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     4020

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     4080

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     4140

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     4200

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     4260

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     4320

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     4380

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     4440

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     4500

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     4560

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     4620

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     4680

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     4740

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     4800

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     4860

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     4920

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     4980

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     5040

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     5100

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     5160

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     5220

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     5280

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     5340

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     5400

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     5460

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     5520

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     5580

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     5640

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     5700

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     5760

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     5820

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     5880

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     5940

atgttgaata ctcatactct tcctttttca ttattattga agcatttatc agggttattg     6000

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     6060

cacatttccc cgaaaagtgc cacctgacgt c                                    6091


<210>  450
<211>  6052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas6

<400>  450
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggctcaggc tatccctatg      960

acgtacccga ctacgcggga tcgggcatgt atctgtcaaa ggttatcatt gcacgcgcgt     1020

ggagtaggga tctgtatcag ctgcaccagg gtctgtggca tcttttcccg aaccgccccg     1080

acgcggcacg agactttctg tttcacgttg aaaaaagaaa cacccccgag ggctgtcatg     1140

tgctcctgca gtctgcccag atgccggtga gcacagctgt ggcgactgtg atcaagacca     1200

agcaggtcga gtttcagctc caggtagggg ttccactgta ttttcgcctg agagctaatc     1260

cgatcaaaac catactggat aatcagaaga ggctcgacag caaaggaaat attaaaaggt     1320

gccgggtccc gctcatcaaa gaggctgagc aaatcgcttg gcttcaacgg aaactgggga     1380

acgcagcccg cgtggaagac gtccacccga ttagtgaacg gccccaatat ttttccggag     1440

acggaaagag cggcaagatt cagacagtct gtttcgaggg ggtgctcacc atcaatgatg     1500

cccccgccct gatagacctg gtgcagcagg gcataggccc cgctaaaagc atgggatgcg     1560

gactgcttag tctggcaccg ctgtaataat ctagagggcc ctattctata gtgtcaccta     1620

aatgctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     1680

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     1740

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     1800

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     1860

gtgggctcta tggcttctga ggcggaaaga accagctggg gctctagggg gtatccccac     1920

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct     1980

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg     2040

ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt     2100

gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca     2160

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga     2220

ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa     2280

gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac     2340

gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag     2400

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt ggaaagtccc     2460

caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag     2520

tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc     2580

cccatggctg actaattttt tttatttatg cagaggccga ggccgcctct gcctctgagc     2640

tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa aagctcccgg     2700

gagcttgtat atccattttc ggatctgatc aagagacagg atgaggatcg tttcgcatga     2760

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct     2820

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc     2880

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcagg     2940

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg     3000

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc     3060

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc     3120

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg     3180

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc     3240

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg cccgacggcg     3300

aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc     3360

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     3420

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     3480

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     3540

agttcttctg agcgggactc tggggttcga aatgaccgac caagcgacgc ccaacctgcc     3600

atcacgagat ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt     3660

ccgggacgcc ggctggatga tcctccagcg cggggatctc atgctggagt tcttcgccca     3720

ccccaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt     3780

cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt     3840

atcttatcat gtctgtatac cgtcgacctc tagctagagc ttggcgtaat catggtcata     3900

gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag     3960

cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg     4020

ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca     4080

acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc     4140

gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg     4200

gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa     4260

ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga     4320

cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag     4380

ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct     4440

taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg     4500

ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc     4560

ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt     4620

aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta     4680

tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac     4740

agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc     4800

ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat     4860

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc     4920

tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt     4980

cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta     5040

aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct     5100

atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg     5160

cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga     5220

tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt     5280

atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt     5340

taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt     5400

tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat     5460

gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc     5520

cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc     5580

cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat     5640

gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag     5700

aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt     5760

accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc     5820

ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa     5880

gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc attattattg     5940

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa     6000

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tc             6052


<210>  451
<211>  6547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas7

<400>  451
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc gaacagaaac      960

ttatatctga ggaggacctc ggatcgggca tgtcaaattt tattaatatt catgttctga     1020

tcagtcatag cccgagttgc ctgaatagag acgacatgaa tatgcagaaa gacgcaattt     1080

tcggtggcaa gaggcgagtc cgaataagca gccaaagtct taagcgagcc atgaggaaga     1140

gcggctatta tgcccagaat atcggcgagt cctcattgcg gaccatccac ctcgcccagt     1200

tgagagacgt cttgaggcag aaactggggg aaagattcga ccagaaaatc attgacaaga     1260

cccttgccct ccttagtggg aagagcgtgg acgaggctga aaaaatctct gccgacgccg     1320

taacgccctg ggttgtgggt gagattgctt ggttttgtga acaggtggcg aaggcggagg     1380

ccgataacct ggatgacaag aagctgctga aggtccttaa ggaggacata gctgccattc     1440

gggtcaattt gcagcaggga gtggatatcg cattgtccgg aagaatggct acatcaggca     1500

tgatgaccga gctgggcaag gtagacggag ccatgagtat cgcacacgcc atcaccaccc     1560

accaagtcga ctcagacatc gactggttca cagcagtaga tgacctccag gagcaggggt     1620

ctgcccacct tgggacacag gagttctctt ccggggtgtt ttatcgctat gctaatatca     1680

atctggcgca gctgcaagaa aacctggggg gagcctctcg agagcaggcc ctggagattg     1740

caactcacgt cgtgcatatg cttgcgacag aggtacctgg cgccaagcag aggacatacg     1800

ctgcttttaa tccagcagat atggtcatgg taaatttctc tgatatgcct ctctccatgg     1860

ccaacgcatt cgagaaggca gtgaaggcaa aggacgggtt cctgcagcca tcaattcaag     1920

cgtttaatca gtattgggac agagtggcga acggctatgg actgaacgga gccgcagctc     1980

agtttagcct cagcgatgtc gatcccataa ctgcacaggt gaaacagatg cctacgttgg     2040

aacagctgaa gtcatgggta agaaataacg gcgaagccta ataatctaga gggccctatt     2100

ctatagtgtc acctaaatgc tagagctcgc tgatcagcct cgactgtgcc ttctagttgc     2160

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2220

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2280

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2340

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct     2400

agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     2460

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     2520

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     2580

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     2640

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     2700

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     2760

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     2820

taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg tgtggaaagt     2880

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     2940

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     3000

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     3060

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     3120

cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     3180

gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag acaggatgag     3240

gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg     3300

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt     3360

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc     3420

tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt     3480

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag     3540

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg     3600

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag     3660

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg     3720

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc     3780

gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca     3840

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc     3900

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg     3960

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct     4020

atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga ccgaccaagc     4080

gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg aaaggttggg     4140

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct     4200

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa     4260

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     4320

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc     4380

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa     4440

catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac     4500

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca     4560

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc     4620

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     4680

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     4740

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     4800

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     4860

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     4920

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct     4980

ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg     5040

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct     5100

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat     5160

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg     5220

ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa     5280

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt     5340

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     5400

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt     5460

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     5520

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat     5580

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac     5640

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg     5700

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag     5760

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt     5820

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt     5880

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt     5940

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt     6000

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct     6060

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt     6120

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac     6180

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa     6240

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa     6300

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca     6360

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct     6420

ttttcattat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga     6480

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc     6540

tgacgtc                                                               6547


<210>  452
<211>  6925
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8

<400>  452
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc atgaatttgc      960

tcattgataa ttggattccg gtgcgccccc ggaacggtgg gaaagtgcag atcatcaatt     1020

tgcaaagtct ctactgttcc agggaccagt ggagactcag cctgccacgg gatgatatgg     1080

agctggcggc gttggctctg ctcgtatgca tcggccagat tattgcgcca gcaaaggatg     1140

acgttgaatt ccggcatcgg ataatgaacc cccttactga agatgagttc cagcagctta     1200

tcgccccatg gatcgacatg ttctacctca accacgccga gcatcctttt atgcagacca     1260

agggagtcaa ggcgaatgat gtgactccca tggagaagct gctggccggt gtatctgggg     1320

cgaccaactg cgcattcgtg aatcagcctg gacaggggga ggccctctgt ggaggctgca     1380

ctgctatagc actttttaac caagctaatc aagcccccgg ctttggtgga gggtttaaga     1440

gtggattgag ggggggcact cccgtaacca cttttgtgag gggaattgat ctgaggtcta     1500

ctgtgttgct gaacgtcctc acactcccaa ggctccagaa gcagttccca aacgaaagtc     1560

ataccgaaaa ccagcccaca tggatcaagc ccatcaaatc taatgagagc ataccggcta     1620

gcagtattgg atttgtacgg ggtctgttct ggcagccagc tcacatcgag ctgtgtgatc     1680

ctattgggat cggcaagtgc tcttgttgtg ggcaggagtc caaccttagg tatactggat     1740

ttctgaaaga gaagtttacc tttacagtaa atgggctctg gccccacccc cactcacctt     1800

gccttgtgac agtgaaaaag ggggaagtcg aggagaagtt tctggccttt acaacttctg     1860

ccccttcctg gactcagatt tccagagtgg tggtagataa gataattcaa aacgagaatg     1920

gcaatagagt ggccgccgtg gtgaaccagt ttcgcaacat cgcccctcag tcccccctgg     1980

agctgattat gggcggttat cggaataacc aggccagtat actcgagcga cggcacgatg     2040

tcctcatgtt caatcaaggt tggcagcaat atggcaatgt gattaacgag atcgtaaccg     2100

tgggcctggg atataagacc gccctgcgga aggcgttgta tacttttgca gaaggcttta     2160

agaataagga ttttaagggt gccggcgtga gtgtccatga aacagctgaa cggcactttt     2220

atcggcagtc cgagctgttg ataccagacg tgctggctaa tgtgaacttc tcacaggccg     2280

acgaagtgat cgctgatctg cgggataaac tgcaccaact gtgcgagatg ctgtttaatc     2340

aaagcgtcgc tccttatgcc caccacccaa agctgatctc cacgctggcc ctggcgcgcg     2400

ccacacttta taaacatctc cgcgaactga aaccccaggg gggccccagc aatggctaat     2460

aatctagagg gccctattct atagtgtcac ctaaatgcta gagctcgctg atcagcctcg     2520

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2580

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2640

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2700

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     2760

agaaccagct ggggctctag ggggtatccc cacgcgccct gtagcggcgc attaagcgcg     2820

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     2880

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     2940

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     3000

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     3060

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     3120

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     3180

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc     3240

agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     3300

tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     3360

aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc     3420

ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt     3480

atgcagaggc cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt     3540

ttggaggcct aggcttttgc aaaaagctcc cgggagcttg tatatccatt ttcggatctg     3600

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt     3660

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct     3720

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga     3780

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg     3840

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact     3900

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg     3960

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct     4020

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg     4080

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt     4140

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg     4200

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc     4260

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag     4320

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt     4380

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgagcggga ctctggggtt     4440

cgaaatgacc gaccaagcga cgcccaacct gccatcacga gatttcgatt ccaccgccgc     4500

cttctatgaa aggttgggct tcggaatcgt tttccgggac gccggctgga tgatcctcca     4560

gcgcggggat ctcatgctgg agttcttcgc ccaccccaac ttgtttattg cagcttataa     4620

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     4680

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta taccgtcgac     4740

ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc     4800

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     4860

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     4920

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     4980

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     5040

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     5100

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     5160

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     5220

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     5280

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     5340

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     5400

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     5460

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     5520

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     5580

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     5640

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     5700

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     5760

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     5820

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     5880

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     5940

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     6000

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     6060

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     6120

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     6180

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     6240

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     6300

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     6360

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     6420

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     6480

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     6540

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     6600

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     6660

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     6720

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     6780

aatactcata ctcttccttt ttcattatta ttgaagcatt tatcagggtt attgtctcat     6840

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     6900

tccccgaaaa gtgccacctg acgtc                                           6925


<210>  453
<211>  7630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FokI-Cas8

<400>  453
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggctcaggc tatccctatg      960

acgtacccga ctacgcgcaa ttggtcaaaa gcgaactgga agagaaaaaa tctgagctca     1020

gacacaagct gaagtatgtg ccccatgaat acatagaact catagaaata gctcgaaacc     1080

ccacgcagga ccggatcctt gaaatgaaag ttatggagtt ttttatgaaa gtgtatgggt     1140

atcgaggaga gcatcttggt ggaagtcgga aaccggatgg ggcaatatac actgttggga     1200

gccccattga ctatggtgtg atagtggaca ccaaggcata cagcggggga tacaatctgc     1260

cgatcgggca ggcagatgag atgcagcgct atgtggagga gaatcaaact aggaacaaac     1320

atattaaccc aaacgaatgg tggaaagtgt atccctcatc tgttacggag ttcaagttcc     1380

tttttgtatc tggccacttt aaaggaaact ataaagcaca gctcacgcga cttaaccaca     1440

tcaccaattg taacggtgct gtactcagtg ttgaggaact cctgatcggt ggtgaaatga     1500

taaaagctgg aaccttgaca ttggaggaag taaggagaaa gtttaataat ggtgagatca     1560

atttcagcgg ctccgaaacg ccgggtacat ccgagtccgc gactcctgag tcaggaggca     1620

gcggctcctc tggtggaagc ggctcaagtg gagggatgaa tttgctcatt gataattgga     1680

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     1740

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     1800

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     1860

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     1920

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     1980

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     2040

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     2100

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     2160

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     2220

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     2280

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     2340

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     2400

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     2460

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     2520

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     2580

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     2640

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     2700

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     2760

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     2820

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     2880

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     2940

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     3000

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     3060

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     3120

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     3180

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     3240

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     3300

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     3360

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     3420

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     3480

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     3540

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     3600

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     3660

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     3720

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     3780

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     3840

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     3900

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     3960

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     4020

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     4080

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     4140

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     4200

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     4260

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     4320

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     4380

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     4440

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     4500

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     4560

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     4620

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     4680

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     4740

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg     4800

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg     4860

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata     4920

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg     4980

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat     5040

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct     5100

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca     5160

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt     5220

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat     5280

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag     5340

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     5400

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt     5460

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca     5520

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact     5580

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct     5640

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc     5700

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     5760

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     5820

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     5880

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     5940

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     6000

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     6060

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     6120

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     6180

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     6240

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     6300

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     6360

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     6420

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     6480

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     6540

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     6600

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     6660

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat     6720

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc     6780

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag     6840

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag     6900

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt     6960

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg     7020

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt     7080

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc     7140

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc     7200

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa     7260

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg     7320

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc     7380

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag     7440

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt     7500

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     7560

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     7620

acctgacgtc                                                            7630


<210>  454
<211>  4804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR(TRAC)

<400>  454
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc ctcaccgagg gcctatttcc      240

catgattcct tcatatttgc atatacgata caaggctgtt agagagataa ttggaattaa      300

tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt aataatttct      360

tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc ttaccgtaac      420

ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa acaccgagtt      480

ccccgcgcca gcggggataa accggttgat ttgcctgcat tggtgttaca cagtctgagt      540

tccccgcgcc agcggggata aaccgtaagt tgtgttcttc tttgcctagg ccttcaggag      600

ttccccgcgc cagcggggat aaaccgtttt tttcggaaag aaccagctgg ggctctaggg      660

ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca      720

gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct      780

ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc cctttagggt      840

tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac      900

gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct      960

ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt     1020

ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag ctgatttaac     1080

aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc     1140

aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccaggt     1200

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     1260

cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg     1320

cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct     1380

ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca     1440

aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca ggatgaggat     1500

cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga     1560

ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc     1620

ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga     1680

atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg     1740

cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc     1800

cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg     1860

atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga     1920

aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc     1980

tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgcgca     2040

tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg     2100

tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct     2160

atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg     2220

accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc     2280

gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg accaagcgac     2340

gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa ggttgggctt     2400

cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc tcatgctgga     2460

gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat aaagcaatag     2520

catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa     2580

actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga gcttggcgta     2640

atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat     2700

acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt     2760

aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta     2820

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc     2880

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     2940

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     3000

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     3060

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     3120

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     3180

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     3240

tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     3300

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     3360

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     3420

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     3480

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     3540

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     3600

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     3660

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     3720

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     3780

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     3840

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     3900

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     3960

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     4020

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     4080

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     4140

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     4200

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     4260

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     4320

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     4380

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     4440

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     4500

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     4560

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     4620

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     4680

tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     4740

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     4800

cgtc                                                                  4804


<210>  455
<211>  10813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas7_NLS-Cse2_NLS-Cas5_NLS-Cas6_NLS-FokI-Cas8

<400>  455
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcagggg tctggggagg ggcgggggtc tttgttgact tgcggggatg     3420

ttgaggagaa tcctggacct cccaaaaaaa aacggaaggt gggctcaggc atgtatctgt     3480

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     3540

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     3600

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     3660

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     3720

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     3780

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     3840

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     3900

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     3960

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     4020

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctggga tccggagagg     4080

gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggacct cccaagaaaa     4140

agagaaaagt aggcggctca caattggtca aaagcgaact ggaagagaaa aaatctgagc     4200

tcagacacaa gctgaagtat gtgccccatg aatacataga actcatagaa atagctcgaa     4260

accccacgca ggaccggatc cttgaaatga aagttatgga gttttttatg aaagtgtatg     4320

ggtatcgagg agagcatctt ggtggaagtc ggaaaccgga tggggcaata tacactgttg     4380

ggagccccat tgactatggt gtgatagtgg acaccaaggc atacagcggg ggatacaatc     4440

tgccgatcgg gcaggcagat gagatgcagc gctatgtgga ggagaatcaa actaggaaca     4500

aacatattaa cccaaacgaa tggtggaaag tgtatccctc atctgttacg gagttcaagt     4560

tcctttttgt atctggccac tttaaaggaa actataaagc acagctcacg cgacttaacc     4620

acatcaccaa ttgtaacggt gctgtactca gtgttgagga actcctgatc ggtggtgaaa     4680

tgataaaagc tggaaccttg acattggagg aagtaaggag aaagtttaat aatggtgaga     4740

tcaatttcag cggctccgaa acgccgggta catccgagtc cgcgactcct gagtcaggag     4800

gcagcggctc ctctggtgga agcggctcaa gtggagggat gaatttgctc attgataatt     4860

ggattccggt gcgcccccgg aacggtggga aagtgcagat catcaatttg caaagtctct     4920

actgttccag ggaccagtgg agactcagcc tgccacggga tgatatggag ctggcggcgt     4980

tggctctgct cgtatgcatc ggccagatta ttgcgccagc aaaggatgac gttgaattcc     5040

ggcatcggat aatgaacccc cttactgaag atgagttcca gcagcttatc gccccatgga     5100

tcgacatgtt ctacctcaac cacgccgagc atccttttat gcagaccaag ggagtcaagg     5160

cgaatgatgt gactcccatg gagaagctgc tggccggtgt atctggggcg accaactgcg     5220

cattcgtgaa tcagcctgga cagggggagg ccctctgtgg aggctgcact gctatagcac     5280

tttttaacca agctaatcaa gcccccggct ttggtggagg gtttaagagt ggattgaggg     5340

ggggcactcc cgtaaccact tttgtgaggg gaattgatct gaggtctact gtgttgctga     5400

acgtcctcac actcccaagg ctccagaagc agttcccaaa cgaaagtcat accgaaaacc     5460

agcccacatg gatcaagccc atcaaatcta atgagagcat accggctagc agtattggat     5520

ttgtacgggg tctgttctgg cagccagctc acatcgagct gtgtgatcct attgggatcg     5580

gcaagtgctc ttgttgtggg caggagtcca accttaggta tactggattt ctgaaagaga     5640

agtttacctt tacagtaaat gggctctggc cccaccccca ctcaccttgc cttgtgacag     5700

tgaaaaaggg ggaagtcgag gagaagtttc tggcctttac aacttctgcc ccttcctgga     5760

ctcagatttc cagagtggtg gtagataaga taattcaaaa cgagaatggc aatagagtgg     5820

ccgccgtggt gaaccagttt cgcaacatcg cccctcagtc ccccctggag ctgattatgg     5880

gcggttatcg gaataaccag gccagtatac tcgagcgacg gcacgatgtc ctcatgttca     5940

atcaaggttg gcagcaatat ggcaatgtga ttaacgagat cgtaaccgtg ggcctgggat     6000

ataagaccgc cctgcggaag gcgttgtata cttttgcaga aggctttaag aataaggatt     6060

ttaagggtgc cggcgtgagt gtccatgaaa cagctgaacg gcacttttat cggcagtccg     6120

agctgttgat accagacgtg ctggctaatg tgaacttctc acaggccgac gaagtgatcg     6180

ctgatctgcg ggataaactg caccaactgt gcgagatgct gtttaatcaa agcgtcgctc     6240

cttatgccca ccacccaaag ctgatctcca cgctggccct ggcgcgcgcc acactttata     6300

aacatctccg cgaactgaaa ccccaggggg gccccagcaa tggctaataa tctagagggc     6360

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     6420

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     6480

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     6540

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     6600

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     6660

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     6720

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     6780

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     6840

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     6900

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     6960

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     7020

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag     7080

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     7140

gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag     7200

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     7260

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc     7320

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     7380

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     7440

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag     7500

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt     7560

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg     7620

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg     7680

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg     7740

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg     7800

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca     7860

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc     7920

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc     7980

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca     8040

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga     8100

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg     8160

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg     8220

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg     8280

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga     8340

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag     8400

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct     8460

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata     8520

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg     8580

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag     8640

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc     8700

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta     8760

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca     8820

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     8880

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     8940

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     9000

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     9060

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     9120

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     9180

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     9240

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     9300

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     9360

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     9420

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     9480

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     9540

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     9600

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     9660

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     9720

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     9780

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     9840

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     9900

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     9960

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    10020

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    10080

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    10140

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    10200

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    10260

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    10320

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    10380

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    10440

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    10500

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    10560

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    10620

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    10680

cttccttttt cattattatt gaagcattta tcagggttat tgtctcatga gcggatacat    10740

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    10800

gccacctgac gtc                                                       10813


<210>  456
<211>  11541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hU6_CRISPR(TRAC), 
       CMV_NLSCas7_NLSCse2_NLSCas5_NLSCas6_NLSFokICas8

<400>  456
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgtgagggcc      240

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg      300

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      360

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      420

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      480

ccggatccta atacgactca ctatagggta aggagatata ccatgggcta gcgagttccc      540

cgcgccagcg gggataaacc ggttgatttg cctgcattgg tgttacacag tctgagttcc      600

ccgcgccagc ggggataaac cgtaagttgt gttcttcttt gcctaggcct tcaggagttc      660

cccgcgccag cggggataaa ccggagctcg ctgagcaata actctgaaac ctcaggcatt      720

tgagaagtct agattttttt cggaaagaac cagctggggc tctagggggt atccccacgc      780

gccctgtagc acgcgttgac attgattatt gactagttat taatagtaat caattacggg      840

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      900

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      960

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc     1020

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga     1080

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg     1140

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat     1200

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt     1260

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc     1320

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc     1380

tctctggcta actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta     1440

tagggagacc caagcttggt accgagctcg gatcgccacc atgcccaaga aaaagagaaa     1500

agtaggatcg ggcgaacaga aacttatatc tgaggaggac ctcggatcgg gcatgtcaaa     1560

ttttattaat attcatgttc tgatcagtca tagcccgagt tgcctgaata gagacgacat     1620

gaatatgcag aaagacgcaa ttttcggtgg caagaggcga gtccgaataa gcagccaaag     1680

tcttaagcga gccatgagga agagcggcta ttatgcccag aatatcggcg agtcctcatt     1740

gcggaccatc cacctcgccc agttgagaga cgtcttgagg cagaaactgg gggaaagatt     1800

cgaccagaaa atcattgaca agacccttgc cctccttagt gggaagagcg tggacgaggc     1860

tgaaaaaatc tctgccgacg ccgtaacgcc ctgggttgtg ggtgagattg cttggttttg     1920

tgaacaggtg gcgaaggcgg aggccgataa cctggatgac aagaagctgc tgaaggtcct     1980

taaggaggac atagctgcca ttcgggtcaa tttgcagcag ggagtggata tcgcattgtc     2040

cggaagaatg gctacatcag gcatgatgac cgagctgggc aaggtagacg gagccatgag     2100

tatcgcacac gccatcacca cccaccaagt cgactcagac atcgactggt tcacagcagt     2160

agatgacctc caggagcagg ggtctgccca ccttgggaca caggagttct cttccggggt     2220

gttttatcgc tatgctaata tcaatctggc gcagctgcaa gaaaacctgg ggggagcctc     2280

tcgagagcag gccctggaga ttgcaactca cgtcgtgcat atgcttgcga cagaggtacc     2340

tggcgccaag cagaggacat acgctgcttt taatccagca gatatggtca tggtaaattt     2400

ctctgatatg cctctctcca tggccaacgc attcgagaag gcagtgaagg caaaggacgg     2460

gttcctgcag ccatcaattc aagcgtttaa tcagtattgg gacagagtgg cgaacggcta     2520

tggactgaac ggagccgcag ctcagtttag cctcagcgat gtcgatccca taactgcaca     2580

ggtgaaacag atgcctacgt tggaacagct gaagtcatgg gtaagaaata acggcgaagc     2640

cggcagcggc gagggcagag gcagcctgct gacctgcggc gacgtggagg agaaccccgg     2700

cccccccaag aaaaagagaa aagtaggatc gggcgattac aaagatcacg atggggacta     2760

caaggatcac gatattgact ataaggacga cgatgacaag ggatcgggca tggccgacga     2820

gattgacgca atggcacttt accgggcctg gcagcagttg gataatggtt catgtgccca     2880

gattcgcaga gttagtgaac ctgacgaact gagagatatc cccgcgtttt acagacttgt     2940

ccaaccgttc ggatgggaga acccacggca ccaacaagca ctccttcgaa tggtcttctg     3000

tttgtccgca ggaaaaaatg taatcagaca ccaagacaaa aagagcgagc aaaccacagg     3060

tatcagcctg ggcagggcac ttgccaactc tgggcggatc aacgaaagga gaatttttca     3120

gctgatacgc gctgatcgga ctgcggacat ggtgcagctg cgcagactcc ttactcatgc     3180

cgaacctgtc ctggattggc ccctgatggc acgcatgctg acttggtggg gaaagagaga     3240

aagacagcaa ctgcttgaag acttcgtgct cactacaaat aagaatgccg gatccggaga     3300

aggaagggga tccctcctca catgtggaga tgtcgaagaa aatcctggac ctcccaagaa     3360

aaagagaaaa gtaggatcgg gcatgcggag ctatctcatc ctgagactgg ccggaccaat     3420

gcaggcctgg ggacagccta ccttcgaagg tacacgcccc acaggccgct ttcctaccag     3480

gagcggcctg ctgggcctgc ttggcgcttg tcttgggatc cagcgcgatg atactagctc     3540

cctgcaagca ctgtcagaga gcgtgcagtt tgccgtaaga tgcgacgaac tgatccttga     3600

tgataggcgg gtcagtgtca ctggtctccg ggactaccac acggtgctgg gggcccggga     3660

ggattatagg ggcctgaaaa gtcacgagac gattcaaacc tggcgcgaat atctgtgcga     3720

tgccagcttc accgtggccc tgtggctgac tccacatgcc actatggtca tcagtgaact     3780

ggaaaaggct gttcttaagc ctcgatatac tccgtatctg ggccgccgga gttgtccact     3840

tacacaccca cttttcctcg gcacctgcca ggccagcgac cctcaaaagg cccttctgaa     3900

ttacgagcca gttggcggtg acatatacag cgaagagtcc gtgacgggac accatcttaa     3960

gttcaccgct cgggacgagc ccatgattac cctcccacgg cagttcgcat caagggagtg     4020

gtacgtcata aaggggggca tggatgtgag tcaggggtct ggggaggggc gggggtcttt     4080

gttgacttgc ggggatgttg aggagaaccc agggccaccc aagaaaaaga gaaaagtagg     4140

ctcaggcggt aaacccatcc caaacccctt gcttggtctc gactcaaccg gatcgggcat     4200

gtatctgtca aaggttatca ttgcacgcgc gtggagtagg gatctgtatc agctgcacca     4260

gggtctgtgg catcttttcc cgaaccgccc cgacgcggca cgagactttc tgtttcacgt     4320

tgaaaaaaga aacacccccg agggctgtca tgtgctcctg cagtctgccc agatgccggt     4380

gagcacagct gtggcgactg tgatcaagac caagcaggtc gagtttcagc tccaggtagg     4440

ggttccactg tattttcgcc tgagagctaa tccgatcaaa accatactgg ataatcagaa     4500

gaggctcgac agcaaaggaa atattaaaag gtgccgggtc ccgctcatca aagaggctga     4560

gcaaatcgct tggcttcaac ggaaactggg gaacgcagcc cgcgtggaag acgtccaccc     4620

gattagtgaa cggccccaat atttttccgg agacggaaag agcggcaaga ttcagacagt     4680

ctgtttcgag ggggtgctca ccatcaatga tgcccccgcc ctgatagacc tggtgcagca     4740

gggcataggc cccgctaaaa gcatgggatg cggactgctt agtctggcac cgctgggatc     4800

cggagagggc agaggaagtc tgctaacatg cggtgacgtc gaggagaatc ctggacctcc     4860

caagaaaaag agaaaagtag gcggctcaca attggtcaaa agcgaactgg aagagaaaaa     4920

atctgagctc agacacaagc tgaagtatgt gccccatgaa tacatagaac tcatagaaat     4980

agctcgaaac cccacgcagg accggatcct tgaaatgaaa gttatggagt tttttatgaa     5040

agtgtatggg tatcgaggag agcatcttgg tggaagtcgg aaaccggatg gggcaatata     5100

cactgttggg agccccattg actatggtgt gatagtggac accaaggcat acagcggggg     5160

atacaatctg ccgatcgggc aggcagatga gatgcagcgc tatgtggagg agaatcaaac     5220

taggaacaaa catattaacc caaacgaatg gtggaaagtg tatccctcat ctgttacgga     5280

gttcaagttc ctttttgtat ctggccactt taaaggaaac tataaagcac agctcacgcg     5340

acttaaccac atcaccaatt gtaacggtgc tgtactcagt gttgaggaac tcctgatcgg     5400

tggtgaaatg ataaaagctg gaaccttgac attggaggaa gtaaggagaa agtttaataa     5460

tggtgagatc aatttcagcg gctccgaaac gccgggtaca tccgagtccg cgactcctga     5520

gtcaggaggc agcggctcct ctggtggaag cggctcaagt ggagggatga atttgctcat     5580

tgataattgg attccggtgc gcccccggaa cggtgggaaa gtgcagatca tcaatttgca     5640

aagtctctac tgttccaggg accagtggag actcagcctg ccacgggatg atatggagct     5700

ggcggcgttg gctctgctcg tatgcatcgg ccagattatt gcgccagcaa aggatgacgt     5760

tgaattccgg catcggataa tgaaccccct tactgaagat gagttccagc agcttatcgc     5820

cccatggatc gacatgttct acctcaacca cgccgagcat ccttttatgc agaccaaggg     5880

agtcaaggcg aatgatgtga ctcccatgga gaagctgctg gccggtgtat ctggggcgac     5940

caactgcgca ttcgtgaatc agcctggaca gggggaggcc ctctgtggag gctgcactgc     6000

tatagcactt tttaaccaag ctaatcaagc ccccggcttt ggtggagggt ttaagagtgg     6060

attgaggggg ggcactcccg taaccacttt tgtgagggga attgatctga ggtctactgt     6120

gttgctgaac gtcctcacac tcccaaggct ccagaagcag ttcccaaacg aaagtcatac     6180

cgaaaaccag cccacatgga tcaagcccat caaatctaat gagagcatac cggctagcag     6240

tattggattt gtacggggtc tgttctggca gccagctcac atcgagctgt gtgatcctat     6300

tgggatcggc aagtgctctt gttgtgggca ggagtccaac cttaggtata ctggatttct     6360

gaaagagaag tttaccttta cagtaaatgg gctctggccc cacccccact caccttgcct     6420

tgtgacagtg aaaaaggggg aagtcgagga gaagtttctg gcctttacaa cttctgcccc     6480

ttcctggact cagatttcca gagtggtggt agataagata attcaaaacg agaatggcaa     6540

tagagtggcc gccgtggtga accagtttcg caacatcgcc cctcagtccc ccctggagct     6600

gattatgggc ggttatcgga ataaccaggc cagtatactc gagcgacggc acgatgtcct     6660

catgttcaat caaggttggc agcaatatgg caatgtgatt aacgagatcg taaccgtggg     6720

cctgggatat aagaccgccc tgcggaaggc gttgtatact tttgcagaag gctttaagaa     6780

taaggatttt aagggtgccg gcgtgagtgt ccatgaaaca gctgaacggc acttttatcg     6840

gcagtccgag ctgttgatac cagacgtgct ggctaatgtg aacttctcac aggccgacga     6900

agtgatcgct gatctgcggg ataaactgca ccaactgtgc gagatgctgt ttaatcaaag     6960

cgtcgctcct tatgcccacc acccaaagct gatctccacg ctggccctgg cgcgcgccac     7020

actttataaa catctccgcg aactgaaacc ccaggggggc cccagcaatg gctaataatc     7080

tagagggccc tattctatag tgtcacctaa atgctagagc tcgctgatca gcctcgactg     7140

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     7200

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     7260

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     7320

aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa     7380

ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta agcgcggcgg     7440

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     7500

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     7560

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     7620

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     7680

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     7740

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     7800

aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg tgtgtcagtt     7860

agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa     7920

ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag     7980

catgcatctc aattagtcag caaccatagt cccgccccta actccgccca tcccgcccct     8040

aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc     8100

agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag gcttttttgg     8160

aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg gatctgatca     8220

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc     8280

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc     8340

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga     8400

cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt ggctggccac     8460

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct     8520

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa     8580

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc     8640

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct     8700

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc     8760

caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg     8820

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct     8880

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct     8940

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca     9000

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct ggggttcgaa     9060

atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac cgccgccttc     9120

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc     9180

ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt     9240

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     9300

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct     9360

agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc     9420

acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga     9480

gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg     9540

tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg     9600

cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     9660

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     9720

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     9780

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     9840

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     9900

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     9960

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt    10020

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc    10080

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc    10140

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg    10200

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca    10260

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc    10320

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat    10380

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt    10440

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt    10500

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc    10560

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc    10620

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata    10680

ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg    10740

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc    10800

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct    10860

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa    10920

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt    10980

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca    11040

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac    11100

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca    11160

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt    11220

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc    11280

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca    11340

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata    11400

ctcatactct tcctttttca ttattattga agcatttatc agggttattg tctcatgagc    11460

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc    11520

cgaaaagtgc cacctgacgt c                                              11541


<210>  457
<211>  2667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3

<400>  457
atggaacctt ttaaatatat atgccattac tggggaaaat cctcaaaaag cttgacgaaa       60

ggaaatgata ttcatctgtt aatttatcat tgccttgatg ttgctgctgt tgcagattgc      120

tggtgggatc aatcagtcgt actgcaaaat actttttgcc gaaatgaaat gctatcaaaa      180

cagagggtga aggcctggct gttatttttc attgctcttc atgatattgg aaagtttgat      240

atacgattcc aatataaatc agcagaaagt tggctgaaat taaatcctgc aacgccatca      300

cttaatggtc catcaacaca aatgtgccgt aaatttaatc atggtgcagc cggtctgtat      360

tggtttaacc aggattcact ttcagagcaa tctctcgggg attttttcag tttttttgat      420

gccgctcctc atccttatga gtcctggttt ccatgggtag aggccgttac aggacatcat      480

ggttttatat tacattccca ggatcaagat aagtcgcgtt gggaaatgcc agcttctctg      540

gcatcttatg ctgcgcaaga taaacaggct cgtgaggagt ggatatctgt actggaagca      600

ttatttttaa cgccagcggg gttatctata aacgatatac cacctgattg ttcatcactg      660

ttagcaggtt tttgctcgct tgctgactgg ttaggctcct ggactacaac gaataccttt      720

ctgtttaatg aggatgcgcc ttccgacata aatgctctga gaacgtattt ccaggaccga      780

cagcaggatg cgagccgggt attggagttg agtggacttg tatcaaataa gcgatgttat      840

gaaggtgttc atgcactact ggacaatggc tatcaaccca gacaattaca ggtgttagtt      900

gatgctcttc cagtagctcc cgggctgacg gtaatagagg cacctacagg ctccggtaaa      960

acggaaacag cgctggccta tgcttggaaa cttattgatc aacaaattgc ggatagtgtt     1020

atttttgccc tcccaacaca agctaccgcg aatgctatgc ttacgagaat ggaagcgagc     1080

gcgagccact tattttcatc cccaaatctt attcttgctc atggcaattc acggtttaac     1140

cacctctttc aatcaataaa atcacgcgcg attactgaac aggggcaaga agaagcgtgg     1200

gttcagtgtt gtcagtggtt gtcacaaagc aataagaaag tgtttcttgg gcaaatcggc     1260

gtttgcacga ttgatcaggt gttgatatcg gtattgccag ttaaacaccg ctttatccgt     1320

ggtttgggaa ttggtcgaag tgttttaatt gttgatgaag ttcatgctta cgacacctat     1380

atgaacggct tgctggaggc agtgctcaag gctcaggctg atgtgggagg gagtgttatt     1440

cttctttccg caaccctacc aatgaaacaa aaacagaaac ttctggatac ttatggtctg     1500

catacagatc cagtggaaaa taactccgca tatccactca ttaactggcg aggtgtgaat     1560

ggtgcgcaac gttttgatct gctagctcat ccagaacaac tcccgccccg cttttcgatt     1620

cagccagaac ctatttgttt agctgacatg ttacctgacc ttacgatgtt agagcgaatg     1680

atcgcagcgg caaacgcggg tgcacaggtc tgtcttattt gcaatttggt tgacgttgca     1740

caagtatgct accaacggct aaaggagcta aataacacgc aagtagatat agatttgttt     1800

catgcgcgct ttacgctgaa cgatcgtcgt gaaaaagaga atcgagttat tagcaatttc     1860

ggcaaaaatg ggaagcgaaa tgttggacgg atacttgtcg caacccaggt cgtggaacaa     1920

tcactcgacg ttgattttga ttggttaatt actcagcatt gtcctgcaga tttgcttttc     1980

caacgattgg gccgtttaca tcgccatcat cgcaaatatc gtcccgctgg ttttgagatt     2040

cctgttgcca ccattttgct gcctgatggc gagggttacg gacgacatga gcatatttat     2100

agcaacgtta gagtcatgtg gcggacgcag caacatattg aggagcttaa tggagcatcc     2160

ttatttttcc ctgatgctta ccggcaatgg ctggatagca tttacgatga tgcggaaatg     2220

gatgagccag aatgggtcgg caatggcatg gataaatttg aaagcgccga gtgtgaaaaa     2280

aggttcaagg ctcgcaaggt cctgcagtgg gctgaagaat atagcttgca ggataacgat     2340

gaaaccattc ttgcggtaac gagggatggg gaaatgagcc tgccattatt gccttatgta     2400

caaacgtctt caggtaaaca actgctcgat ggccaggtct acgaggacct aagtcatgaa     2460

cagcagtatg aggcgcttgc acttaatcgc gtcaatgtac ccttcacctg gaaacgtagt     2520

ttttctgaag tagtagatga agatgggtta ctttggctgg aagggaaaca gaatctggat     2580

ggatgggtct ggcagggtaa cagtattgtt attacctata caggggatga agggatgacc     2640

agagtcatcc ctgcaaatcc caaataa                                         2667


<210>  458
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3

<400>  458

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  459
<211>  3828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas3

<400>  459
atgcaccatc accatcacca tggaaaaatc gaagaaggta aactggtaat ctggattaac       60

ggcgataaag gctataacgg tctcgctgaa gtcggtaaga aattcgagaa agataccgga      120

attaaagtca ccgttgagca tccggataaa ctggaagaga aattcccaca ggttgcggca      180

actggcgatg gccctgacat tatcttctgg gcacacgacc gctttggtgg ctacgctcaa      240

tctggcctgt tggctgaaat caccccggac aaagcgttcc aggacaagct gtatccgttt      300

acctgggatg ccgtacgtta caacggcaag ctgattgctt acccgatcgc tgttgaagcg      360

ttatcgctga tttataacaa agatctgctg ccgaacccgc caaaaacctg ggaagagatc      420

ccggcgctgg ataaagaact gaaagcgaaa ggtaagagcg cgctgatgtt caacctgcaa      480

gaaccgtact tcacctggcc gctgattgct gctgacgggg gttatgcgtt caagtatgaa      540

aacggcaagt acgacattaa agacgtgggc gtggataacg ctggcgcgaa agcgggtctg      600

accttcctgg ttgacctgat taaaaacaaa cacatgaatg cagacaccga ttactccatc      660

gcagaagctg cctttaataa aggcgaaaca gcgatgacca tcaacggccc gtgggcatgg      720

tccaacatcg acaccagcaa agtgaattat ggtgtaacgg tactgccgac cttcaagggt      780

caaccatcca aaccgttcgt tggcgtgctg agcgcaggta ttaacgccgc cagtccgaac      840

aaagagctgg caaaagagtt cctcgaaaac tatctgctga ctgatgaagg tctggaagcg      900

gttaataaag acaaaccgct gggtgccgta gcgctgaagt cttacgagga agagttggcg      960

aaagatccac gtattgccgc cactatggaa aacgcccaga aaggtgaaat catgccgaac     1020

atcccgcaga tgtccgcttt ctggtatgcc gtgcgtactg cggtgatcaa cgccgccagc     1080

ggtcgtcaga ctgtcgatga agccctgaaa gacgcgcaga ctaatgggat cgaggaaaac     1140

ctgtacttcc aatccaatgc aatggaacct tttaaatata tatgccatta ctggggaaaa     1200

tcctcaaaaa gcttgacgaa aggaaatgat attcatctgt taatttatca ttgccttgat     1260

gttgctgctg ttgcagattg ctggtgggat caatcagtcg tactgcaaaa tactttttgc     1320

cgaaatgaaa tgctatcaaa acagagggtg aaggcctggc tgttattttt cattgctctt     1380

catgatattg gaaagtttga tatacgattc caatataaat cagcagaaag ttggctgaaa     1440

ttaaatcctg caacgccatc acttaatggt ccatcaacac aaatgtgccg taaatttaat     1500

catggtgcag ccggtctgta ttggtttaac caggattcac tttcagagca atctctcggg     1560

gattttttca gtttttttga tgccgctcct catccttatg agtcctggtt tccatgggta     1620

gaggccgtta caggacatca tggttttata ttacattccc aggatcaaga taagtcgcgt     1680

tgggaaatgc cagcttctct ggcatcttat gctgcgcaag ataaacaggc tcgtgaggag     1740

tggatatctg tactggaagc attattttta acgccagcgg ggttatctat aaacgatata     1800

ccacctgatt gttcatcact gttagcaggt ttttgctcgc ttgctgactg gttaggctcc     1860

tggactacaa cgaatacctt tctgtttaat gaggatgcgc cttccgacat aaatgctctg     1920

agaacgtatt tccaggaccg acagcaggat gcgagccggg tattggagtt gagtggactt     1980

gtatcaaata agcgatgtta tgaaggtgtt catgcactac tggacaatgg ctatcaaccc     2040

agacaattac aggtgttagt tgatgctctt ccagtagctc ccgggctgac ggtaatagag     2100

gcacctacag gctccggtaa aacggaaaca gcgctggcct atgcttggaa acttattgat     2160

caacaaattg cggatagtgt tatttttgcc ctcccaacac aagctaccgc gaatgctatg     2220

cttacgagaa tggaagcgag cgcgagccac ttattttcat ccccaaatct tattcttgct     2280

catggcaatt cacggtttaa ccacctcttt caatcaataa aatcacgcgc gattactgaa     2340

caggggcaag aagaagcgtg ggttcagtgt tgtcagtggt tgtcacaaag caataagaaa     2400

gtgtttcttg ggcaaatcgg cgtttgcacg attgatcagg tgttgatatc ggtattgcca     2460

gttaaacacc gctttatccg tggtttggga attggtcgaa gtgttttaat tgttgatgaa     2520

gttcatgctt acgacaccta tatgaacggc ttgctggagg cagtgctcaa ggctcaggct     2580

gatgtgggag ggagtgttat tcttctttcc gcaaccctac caatgaaaca aaaacagaaa     2640

cttctggata cttatggtct gcatacagat ccagtggaaa ataactccgc atatccactc     2700

attaactggc gaggtgtgaa tggtgcgcaa cgttttgatc tgctagctca tccagaacaa     2760

ctcccgcccc gcttttcgat tcagccagaa cctatttgtt tagctgacat gttacctgac     2820

cttacgatgt tagagcgaat gatcgcagcg gcaaacgcgg gtgcacaggt ctgtcttatt     2880

tgcaatttgg ttgacgttgc acaagtatgc taccaacggc taaaggagct aaataacacg     2940

caagtagata tagatttgtt tcatgcgcgc tttacgctga acgatcgtcg tgaaaaagag     3000

aatcgagtta ttagcaattt cggcaaaaat gggaagcgaa atgttggacg gatacttgtc     3060

gcaacccagg tcgtggaaca atcactcgac gttgattttg attggttaat tactcagcat     3120

tgtcctgcag atttgctttt ccaacgattg ggccgtttac atcgccatca tcgcaaatat     3180

cgtcccgctg gttttgagat tcctgttgcc accattttgc tgcctgatgg cgagggttac     3240

ggacgacatg agcatattta tagcaacgtt agagtcatgt ggcggacgca gcaacatatt     3300

gaggagctta atggagcatc cttatttttc cctgatgctt accggcaatg gctggatagc     3360

atttacgatg atgcggaaat ggatgagcca gaatgggtcg gcaatggcat ggataaattt     3420

gaaagcgccg agtgtgaaaa aaggttcaag gctcgcaagg tcctgcagtg ggctgaagaa     3480

tatagcttgc aggataacga tgaaaccatt cttgcggtaa cgagggatgg ggaaatgagc     3540

ctgccattat tgccttatgt acaaacgtct tcaggtaaac aactgctcga tggccaggtc     3600

tacgaggacc taagtcatga acagcagtat gaggcgcttg cacttaatcg cgtcaatgta     3660

cccttcacct ggaaacgtag tttttctgaa gtagtagatg aagatgggtt actttggctg     3720

gaagggaaac agaatctgga tggatgggtc tggcagggta acagtattgt tattacctat     3780

acaggggatg aagggatgac cagagtcatc cctgcaaatc ccaaataa                  3828


<210>  460
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas3

<400>  460

Met His His His His His His Gly Lys Ile Glu Glu Gly Lys Leu Val 
1               5                   10                  15      


Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly 
            20                  25                  30          


Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro 
        35                  40                  45              


Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly 
    50                  55                  60                  


Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln 
65                  70                  75                  80  


Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys 
                85                  90                  95      


Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile 
            100                 105                 110         


Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp 
        115                 120                 125             


Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp 
    130                 135                 140                 


Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln 
145                 150                 155                 160 


Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala 
                165                 170                 175     


Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp 
            180                 185                 190         


Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys 
        195                 200                 205             


Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala 
    210                 215                 220                 


Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp 
225                 230                 235                 240 


Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro 
                245                 250                 255     


Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala 
            260                 265                 270         


Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu 
        275                 280                 285             


Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp 
    290                 295                 300                 


Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala 
305                 310                 315                 320 


Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu 
                325                 330                 335     


Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg 
            340                 345                 350         


Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala 
        355                 360                 365             


Leu Lys Asp Ala Gln Thr Asn Gly Ile Glu Glu Asn Leu Tyr Phe Gln 
    370                 375                 380                 


Ser Asn Ala Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys 
385                 390                 395                 400 


Ser Ser Lys Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr 
                405                 410                 415     


His Cys Leu Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser 
            420                 425                 430         


Val Val Leu Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln 
        435                 440                 445             


Arg Val Lys Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly 
    450                 455                 460                 


Lys Phe Asp Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys 
465                 470                 475                 480 


Leu Asn Pro Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys 
                485                 490                 495     


Arg Lys Phe Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp 
            500                 505                 510         


Ser Leu Ser Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala 
        515                 520                 525             


Ala Pro His Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr 
    530                 535                 540                 


Gly His His Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg 
545                 550                 555                 560 


Trp Glu Met Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln 
                565                 570                 575     


Ala Arg Glu Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro 
            580                 585                 590         


Ala Gly Leu Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu 
        595                 600                 605             


Ala Gly Phe Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr 
    610                 615                 620                 


Asn Thr Phe Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu 
625                 630                 635                 640 


Arg Thr Tyr Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu 
                645                 650                 655     


Leu Ser Gly Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala 
            660                 665                 670         


Leu Leu Asp Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp 
        675                 680                 685             


Ala Leu Pro Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly 
    690                 695                 700                 


Ser Gly Lys Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp 
705                 710                 715                 720 


Gln Gln Ile Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr 
                725                 730                 735     


Ala Asn Ala Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe 
            740                 745                 750         


Ser Ser Pro Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His 
        755                 760                 765             


Leu Phe Gln Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu 
    770                 775                 780                 


Glu Ala Trp Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys 
785                 790                 795                 800 


Val Phe Leu Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile 
                805                 810                 815     


Ser Val Leu Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly 
            820                 825                 830         


Arg Ser Val Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met 
        835                 840                 845             


Asn Gly Leu Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly 
    850                 855                 860                 


Ser Val Ile Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys 
865                 870                 875                 880 


Leu Leu Asp Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser 
                885                 890                 895     


Ala Tyr Pro Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe 
            900                 905                 910         


Asp Leu Leu Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln 
        915                 920                 925             


Pro Glu Pro Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu 
    930                 935                 940                 


Glu Arg Met Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile 
945                 950                 955                 960 


Cys Asn Leu Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu 
                965                 970                 975     


Leu Asn Asn Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr 
            980                 985                 990         


Leu Asn Asp Arg Arg Glu Lys Glu  Asn Arg Val Ile Ser  Asn Phe Gly 
        995                 1000                 1005             


Lys Asn  Gly Lys Arg Asn Val  Gly Arg Ile Leu Val  Ala Thr Gln 
    1010                 1015                 1020             


Val Val  Glu Gln Ser Leu Asp  Val Asp Phe Asp Trp  Leu Ile Thr 
    1025                 1030                 1035             


Gln His  Cys Pro Ala Asp Leu  Leu Phe Gln Arg Leu  Gly Arg Leu 
    1040                 1045                 1050             


His Arg  His His Arg Lys Tyr  Arg Pro Ala Gly Phe  Glu Ile Pro 
    1055                 1060                 1065             


Val Ala  Thr Ile Leu Leu Pro  Asp Gly Glu Gly Tyr  Gly Arg His 
    1070                 1075                 1080             


Glu His  Ile Tyr Ser Asn Val  Arg Val Met Trp Arg  Thr Gln Gln 
    1085                 1090                 1095             


His Ile  Glu Glu Leu Asn Gly  Ala Ser Leu Phe Phe  Pro Asp Ala 
    1100                 1105                 1110             


Tyr Arg  Gln Trp Leu Asp Ser  Ile Tyr Asp Asp Ala  Glu Met Asp 
    1115                 1120                 1125             


Glu Pro  Glu Trp Val Gly Asn  Gly Met Asp Lys Phe  Glu Ser Ala 
    1130                 1135                 1140             


Glu Cys  Glu Lys Arg Phe Lys  Ala Arg Lys Val Leu  Gln Trp Ala 
    1145                 1150                 1155             


Glu Glu  Tyr Ser Leu Gln Asp  Asn Asp Glu Thr Ile  Leu Ala Val 
    1160                 1165                 1170             


Thr Arg  Asp Gly Glu Met Ser  Leu Pro Leu Leu Pro  Tyr Val Gln 
    1175                 1180                 1185             


Thr Ser  Ser Gly Lys Gln Leu  Leu Asp Gly Gln Val  Tyr Glu Asp 
    1190                 1195                 1200             


Leu Ser  His Glu Gln Gln Tyr  Glu Ala Leu Ala Leu  Asn Arg Val 
    1205                 1210                 1215             


Asn Val  Pro Phe Thr Trp Lys  Arg Ser Phe Ser Glu  Val Val Asp 
    1220                 1225                 1230             


Glu Asp  Gly Leu Leu Trp Leu  Glu Gly Lys Gln Asn  Leu Asp Gly 
    1235                 1240                 1245             


Trp Val  Trp Gln Gly Asn Ser  Ile Val Ile Thr Tyr  Thr Gly Asp 
    1250                 1255                 1260             


Glu Gly  Met Thr Arg Val Ile  Pro Ala Asn Pro Lys  
    1265                 1270                 1275 


<210>  461
<211>  9125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: His6-MBP-TEV-Cas3

<400>  461
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaact agtaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatgt     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaactaa ggaggtccgc tatgcaccat caccatcacc atggaaaaat     5100

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga     5160

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa     5220

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg     5280

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga     5340

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa     5400

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct     5460

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa     5520

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc     5580

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     5640

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     5700

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     5760

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     5820

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     5880

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     5940

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     6000

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     6060

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     6120

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     6180

agacgcgcag actaatggga tcgaggaaaa cctgtacttc caatccaatg caatggaacc     6240

ttttaaatat atatgccatt actggggaaa atcctcaaaa agcttgacga aaggaaatga     6300

tattcatctg ttaatttatc attgccttga tgttgctgct gttgcagatt gctggtggga     6360

tcaatcagtc gtactgcaaa atactttttg ccgaaatgaa atgctatcaa aacagagggt     6420

gaaggcctgg ctgttatttt tcattgctct tcatgatatt ggaaagtttg atatacgatt     6480

ccaatataaa tcagcagaaa gttggctgaa attaaatcct gcaacgccat cacttaatgg     6540

tccatcaaca caaatgtgcc gtaaatttaa tcatggtgca gccggtctgt attggtttaa     6600

ccaggattca ctttcagagc aatctctcgg ggattttttc agtttttttg atgccgctcc     6660

tcatccttat gagtcctggt ttccatgggt agaggccgtt acaggacatc atggttttat     6720

attacattcc caggatcaag ataagtcgcg ttgggaaatg ccagcttctc tggcatctta     6780

tgctgcgcaa gataaacagg ctcgtgagga gtggatatct gtactggaag cattattttt     6840

aacgccagcg gggttatcta taaacgatat accacctgat tgttcatcac tgttagcagg     6900

tttttgctcg cttgctgact ggttaggctc ctggactaca acgaatacct ttctgtttaa     6960

tgaggatgcg ccttccgaca taaatgctct gagaacgtat ttccaggacc gacagcagga     7020

tgcgagccgg gtattggagt tgagtggact tgtatcaaat aagcgatgtt atgaaggtgt     7080

tcatgcacta ctggacaatg gctatcaacc cagacaatta caggtgttag ttgatgctct     7140

tccagtagct cccgggctga cggtaataga ggcacctaca ggctccggta aaacggaaac     7200

agcgctggcc tatgcttgga aacttattga tcaacaaatt gcggatagtg ttatttttgc     7260

cctcccaaca caagctaccg cgaatgctat gcttacgaga atggaagcga gcgcgagcca     7320

cttattttca tccccaaatc ttattcttgc tcatggcaat tcacggttta accacctctt     7380

tcaatcaata aaatcacgcg cgattactga acaggggcaa gaagaagcgt gggttcagtg     7440

ttgtcagtgg ttgtcacaaa gcaataagaa agtgtttctt gggcaaatcg gcgtttgcac     7500

gattgatcag gtgttgatat cggtattgcc agttaaacac cgctttatcc gtggtttggg     7560

aattggtcga agtgttttaa ttgttgatga agttcatgct tacgacacct atatgaacgg     7620

cttgctggag gcagtgctca aggctcaggc tgatgtggga gggagtgtta ttcttctttc     7680

cgcaacccta ccaatgaaac aaaaacagaa acttctggat acttatggtc tgcatacaga     7740

tccagtggaa aataactccg catatccact cattaactgg cgaggtgtga atggtgcgca     7800

acgttttgat ctgctagctc atccagaaca actcccgccc cgcttttcga ttcagccaga     7860

acctatttgt ttagctgaca tgttacctga ccttacgatg ttagagcgaa tgatcgcagc     7920

ggcaaacgcg ggtgcacagg tctgtcttat ttgcaatttg gttgacgttg cacaagtatg     7980

ctaccaacgg ctaaaggagc taaataacac gcaagtagat atagatttgt ttcatgcgcg     8040

ctttacgctg aacgatcgtc gtgaaaaaga gaatcgagtt attagcaatt tcggcaaaaa     8100

tgggaagcga aatgttggac ggatacttgt cgcaacccag gtcgtggaac aatcactcga     8160

cgttgatttt gattggttaa ttactcagca ttgtcctgca gatttgcttt tccaacgatt     8220

gggccgttta catcgccatc atcgcaaata tcgtcccgct ggttttgaga ttcctgttgc     8280

caccattttg ctgcctgatg gcgagggtta cggacgacat gagcatattt atagcaacgt     8340

tagagtcatg tggcggacgc agcaacatat tgaggagctt aatggagcat ccttattttt     8400

ccctgatgct taccggcaat ggctggatag catttacgat gatgcggaaa tggatgagcc     8460

agaatgggtc ggcaatggca tggataaatt tgaaagcgcc gagtgtgaaa aaaggttcaa     8520

ggctcgcaag gtcctgcagt gggctgaaga atatagcttg caggataacg atgaaaccat     8580

tcttgcggta acgagggatg gggaaatgag cctgccatta ttgccttatg tacaaacgtc     8640

ttcaggtaaa caactgctcg atggccaggt ctacgaggac ctaagtcatg aacagcagta     8700

tgaggcgctt gcacttaatc gcgtcaatgt acccttcacc tggaaacgta gtttttctga     8760

agtagtagat gaagatgggt tactttggct ggaagggaaa cagaatctgg atggatgggt     8820

ctggcagggt aacagtattg ttattaccta tacaggggat gaagggatga ccagagtcat     8880

ccctgcaaat cccaaataat aataacattg gaagtggata acggatccga attcgagcgc     8940

cgtcgacaag cttgcggccg cactcgagca ccaccaccac caccactgag atccggctgc     9000

taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata     9060

accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc     9120

cggat                                                                 9125


<210>  462
<211>  2667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3, human codon optimized

<400>  462
atggagcctt ttaaatatat ttgtcattac tggggtaaga gttccaagag cctgacaaaa       60

ggcaatgata tacatctttt gatctatcac tgtctcgacg tcgcagcggt agcggattgc      120

tggtgggatc aaagtgtcgt gctccagaac acgttttgtc gaaacgaaat gctcagcaag      180

cagcgggtaa aagcatggct ccttttcttt attgctctcc acgacatagg caaattcgac      240

attaggttcc agtacaaatc tgcagagagt tggttgaaat tgaacccggc cacccctagc      300

ctgaacggcc cttcaactca gatgtgcagg aaatttaacc atggagccgc tgggttgtat      360

tggtttaatc aggacagttt gtcagagcaa agtctggggg atttcttctc cttttttgac      420

gccgcgcctc atccttacga gagctggttt ccatgggtcg aggccgtcac agggcaccat      480

ggctttattc ttcactctca ggaccaagac aaatctcgat gggaaatgcc tgccagtctg      540

gcgtcttacg ccgcgcagga taagcaagca cgagaagaat ggatttccgt cttggaggcg      600

ctgtttctca cacccgccgg gctctctatc aacgacatac cccccgattg ctctagtctg      660

cttgccggtt tttgctccct tgccgattgg cttggttcat ggacgaccac caatacgttt      720

ttgttcaatg aagatgcacc atctgatata aatgcattga ggacgtattt tcaagacaga      780

cagcaagatg cctccagagt tttggagctt tctggacttg tatcaaataa gagatgctac      840

gaaggagtgc atgctctgct ggacaacggc taccagccac gacaacttca agttctcgtt      900

gatgccctcc cggtggctcc ggggttgacc gtcatagagg cgcctactgg atcagggaag      960

accgagacag ccttggccta tgcgtggaaa ctgatagatc aacagattgc cgactcagtg     1020

atcttcgcgc tgccaactca ggcaacagcc aacgcgatgc tgacacgcat ggaggccagc     1080

gcaagtcacc ttttctctag tccaaatctg atactggccc atggtaattc taggtttaac     1140

catctgtttc agtccatcaa gtctagggcg ataactgagc aaggacagga agaagcctgg     1200

gttcaatgct gccagtggct tagccagagt aacaagaaag tattcttggg acagattggt     1260

gtctgcacaa tagaccaagt actcatctca gttttgcctg ttaagcaccg attcatacga     1320

ggacttggaa tcgggcgcag tgtcctcata gtagatgagg tgcatgctta cgacacctac     1380

atgaacggtt tgctcgaggc ggtgctcaaa gcacaagctg atgtcggagg tagcgtgatc     1440

cttctcagcg ctacgcttcc tatgaaacag aagcagaagt tgctcgatac ctatggtctg     1500

catacggatc ctgtggaaaa taatagtgcc taccccctca taaactggag gggagtaaat     1560

ggtgcacaga ggtttgacct tcttgctcac cctgagcagc ttcctccccg gttttccata     1620

cagccggagc cgatttgtct tgccgacatg cttccagatc tcacaatgct cgaacggatg     1680

atcgcggccg ctaatgccgg cgcacaagtc tgtctcatct gtaaccttgt cgatgtagcg     1740

caggtttgtt accaacgact caaagaactg aataatacac aagtagacat agatctgttc     1800

catgctcgct ttacactcaa tgacagaagg gaaaaagaaa atcgggtcat ctcaaatttt     1860

ggtaagaacg gaaaacgaaa cgttggccga atcctcgtcg caacccaggt agtggagcag     1920

tccctcgatg tggactttga ctggcttatt acacagcact gccctgctga cctcctgttc     1980

cagcgacttg gcagattgca tagacatcac cggaaatatc ggcctgcagg ttttgagata     2040

ccagtcgcaa ctattcttct ccccgacggg gaagggtacg ggcgacacga gcacatctat     2100

agcaacgtac gggtaatgtg gcggacgcaa caacacatcg aggaacttaa cggagcatcc     2160

ctgtttttcc ccgatgccta tagacaatgg ctcgacagta tttatgatga cgccgaaatg     2220

gacgaacccg agtgggtcgg aaatggtatg gataaatttg aatccgcaga atgtgaaaaa     2280

cggttcaaag cacggaaggt cctccagtgg gctgaggagt attcattgca ggataacgac     2340

gaaaccatct tggctgtcac tagagacggc gaaatgtccc ttccactgct tccttatgtt     2400

caaacctctt ctgggaaaca gcttcttgat ggccaggtat atgaggacct gtcccacgaa     2460

caacagtacg aggcacttgc cttgaaccgc gttaatgtac ctttcacttg gaaacgatca     2520

ttttcagagg tcgtagatga agatgggctc ctttggctgg aaggcaaaca aaacctggat     2580

ggatgggtat ggcagggaaa ctctattgta ataacataca ctggcgatga gggtatgacg     2640

agggttatac cggcgaatcc gaaataa                                         2667


<210>  463
<211>  2697
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3-NLS

<400>  463
atggagcctt ttaaatatat ttgtcattac tggggtaaga gttccaagag cctgacaaaa       60

ggcaatgata tacatctttt gatctatcac tgtctcgacg tcgcagcggt agcggattgc      120

tggtgggatc aaagtgtcgt gctccagaac acgttttgtc gaaacgaaat gctcagcaag      180

cagcgggtaa aagcatggct ccttttcttt attgctctcc acgacatagg caaattcgac      240

attaggttcc agtacaaatc tgcagagagt tggttgaaat tgaacccggc cacccctagc      300

ctgaacggcc cttcaactca gatgtgcagg aaatttaacc atggagccgc tgggttgtat      360

tggtttaatc aggacagttt gtcagagcaa agtctggggg atttcttctc cttttttgac      420

gccgcgcctc atccttacga gagctggttt ccatgggtcg aggccgtcac agggcaccat      480

ggctttattc ttcactctca ggaccaagac aaatctcgat gggaaatgcc tgccagtctg      540

gcgtcttacg ccgcgcagga taagcaagca cgagaagaat ggatttccgt cttggaggcg      600

ctgtttctca cacccgccgg gctctctatc aacgacatac cccccgattg ctctagtctg      660

cttgccggtt tttgctccct tgccgattgg cttggttcat ggacgaccac caatacgttt      720

ttgttcaatg aagatgcacc atctgatata aatgcattga ggacgtattt tcaagacaga      780

cagcaagatg cctccagagt tttggagctt tctggacttg tatcaaataa gagatgctac      840

gaaggagtgc atgctctgct ggacaacggc taccagccac gacaacttca agttctcgtt      900

gatgccctcc cggtggctcc ggggttgacc gtcatagagg cgcctactgg atcagggaag      960

accgagacag ccttggccta tgcgtggaaa ctgatagatc aacagattgc cgactcagtg     1020

atcttcgcgc tgccaactca ggcaacagcc aacgcgatgc tgacacgcat ggaggccagc     1080

gcaagtcacc ttttctctag tccaaatctg atactggccc atggtaattc taggtttaac     1140

catctgtttc agtccatcaa gtctagggcg ataactgagc aaggacagga agaagcctgg     1200

gttcaatgct gccagtggct tagccagagt aacaagaaag tattcttggg acagattggt     1260

gtctgcacaa tagaccaagt actcatctca gttttgcctg ttaagcaccg attcatacga     1320

ggacttggaa tcgggcgcag tgtcctcata gtagatgagg tgcatgctta cgacacctac     1380

atgaacggtt tgctcgaggc ggtgctcaaa gcacaagctg atgtcggagg tagcgtgatc     1440

cttctcagcg ctacgcttcc tatgaaacag aagcagaagt tgctcgatac ctatggtctg     1500

catacggatc ctgtggaaaa taatagtgcc taccccctca taaactggag gggagtaaat     1560

ggtgcacaga ggtttgacct tcttgctcac cctgagcagc ttcctccccg gttttccata     1620

cagccggagc cgatttgtct tgccgacatg cttccagatc tcacaatgct cgaacggatg     1680

atcgcggccg ctaatgccgg cgcacaagtc tgtctcatct gtaaccttgt cgatgtagcg     1740

caggtttgtt accaacgact caaagaactg aataatacac aagtagacat agatctgttc     1800

catgctcgct ttacactcaa tgacagaagg gaaaaagaaa atcgggtcat ctcaaatttt     1860

ggtaagaacg gaaaacgaaa cgttggccga atcctcgtcg caacccaggt agtggagcag     1920

tccctcgatg tggactttga ctggcttatt acacagcact gccctgctga cctcctgttc     1980

cagcgacttg gcagattgca tagacatcac cggaaatatc ggcctgcagg ttttgagata     2040

ccagtcgcaa ctattcttct ccccgacggg gaagggtacg ggcgacacga gcacatctat     2100

agcaacgtac gggtaatgtg gcggacgcaa caacacatcg aggaacttaa cggagcatcc     2160

ctgtttttcc ccgatgccta tagacaatgg ctcgacagta tttatgatga cgccgaaatg     2220

gacgaacccg agtgggtcgg aaatggtatg gataaatttg aatccgcaga atgtgaaaaa     2280

cggttcaaag cacggaaggt cctccagtgg gctgaggagt attcattgca ggataacgac     2340

gaaaccatct tggctgtcac tagagacggc gaaatgtccc ttccactgct tccttatgtt     2400

caaacctctt ctgggaaaca gcttcttgat ggccaggtat atgaggacct gtcccacgaa     2460

caacagtacg aggcacttgc cttgaaccgc gttaatgtac ctttcacttg gaaacgatca     2520

ttttcagagg tcgtagatga agatgggctc ctttggctgg aaggcaaaca aaacctggat     2580

ggatgggtat ggcagggaaa ctctattgta ataacataca ctggcgatga gggtatgacg     2640

agggttatac cggcgaatcc gaaatccggg tcacccaaaa agaagagaaa agtataa        2697


<210>  464
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3-NLS

<400>  464

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys Ser Gly Ser Pro Lys Lys Lys Arg 
                885                 890                 895     


Lys Val 
        


<210>  465
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3-NLS

<400>  465
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc caccatggag ccttttaaat atatttgtca      960

ttactggggt aagagttcca agagcctgac aaaaggcaat gatatacatc ttttgatcta     1020

tcactgtctc gacgtcgcag cggtagcgga ttgctggtgg gatcaaagtg tcgtgctcca     1080

gaacacgttt tgtcgaaacg aaatgctcag caagcagcgg gtaaaagcat ggctcctttt     1140

ctttattgct ctccacgaca taggcaaatt cgacattagg ttccagtaca aatctgcaga     1200

gagttggttg aaattgaacc cggccacccc tagcctgaac ggcccttcaa ctcagatgtg     1260

caggaaattt aaccatggag ccgctgggtt gtattggttt aatcaggaca gtttgtcaga     1320

gcaaagtctg ggggatttct tctccttttt tgacgccgcg cctcatcctt acgagagctg     1380

gtttccatgg gtcgaggccg tcacagggca ccatggcttt attcttcact ctcaggacca     1440

agacaaatct cgatgggaaa tgcctgccag tctggcgtct tacgccgcgc aggataagca     1500

agcacgagaa gaatggattt ccgtcttgga ggcgctgttt ctcacacccg ccgggctctc     1560

tatcaacgac ataccccccg attgctctag tctgcttgcc ggtttttgct cccttgccga     1620

ttggcttggt tcatggacga ccaccaatac gtttttgttc aatgaagatg caccatctga     1680

tataaatgca ttgaggacgt attttcaaga cagacagcaa gatgcctcca gagttttgga     1740

gctttctgga cttgtatcaa ataagagatg ctacgaagga gtgcatgctc tgctggacaa     1800

cggctaccag ccacgacaac ttcaagttct cgttgatgcc ctcccggtgg ctccggggtt     1860

gaccgtcata gaggcgccta ctggatcagg gaagaccgag acagccttgg cctatgcgtg     1920

gaaactgata gatcaacaga ttgccgactc agtgatcttc gcgctgccaa ctcaggcaac     1980

agccaacgcg atgctgacac gcatggaggc cagcgcaagt caccttttct ctagtccaaa     2040

tctgatactg gcccatggta attctaggtt taaccatctg tttcagtcca tcaagtctag     2100

ggcgataact gagcaaggac aggaagaagc ctgggttcaa tgctgccagt ggcttagcca     2160

gagtaacaag aaagtattct tgggacagat tggtgtctgc acaatagacc aagtactcat     2220

ctcagttttg cctgttaagc accgattcat acgaggactt ggaatcgggc gcagtgtcct     2280

catagtagat gaggtgcatg cttacgacac ctacatgaac ggtttgctcg aggcggtgct     2340

caaagcacaa gctgatgtcg gaggtagcgt gatccttctc agcgctacgc ttcctatgaa     2400

acagaagcag aagttgctcg atacctatgg tctgcatacg gatcctgtgg aaaataatag     2460

tgcctacccc ctcataaact ggaggggagt aaatggtgca cagaggtttg accttcttgc     2520

tcaccctgag cagcttcctc cccggttttc catacagccg gagccgattt gtcttgccga     2580

catgcttcca gatctcacaa tgctcgaacg gatgatcgcg gccgctaatg ccggcgcaca     2640

agtctgtctc atctgtaacc ttgtcgatgt agcgcaggtt tgttaccaac gactcaaaga     2700

actgaataat acacaagtag acatagatct gttccatgct cgctttacac tcaatgacag     2760

aagggaaaaa gaaaatcggg tcatctcaaa ttttggtaag aacggaaaac gaaacgttgg     2820

ccgaatcctc gtcgcaaccc aggtagtgga gcagtccctc gatgtggact ttgactggct     2880

tattacacag cactgccctg ctgacctcct gttccagcga cttggcagat tgcatagaca     2940

tcaccggaaa tatcggcctg caggttttga gataccagtc gcaactattc ttctccccga     3000

cggggaaggg tacgggcgac acgagcacat ctatagcaac gtacgggtaa tgtggcggac     3060

gcaacaacac atcgaggaac ttaacggagc atccctgttt ttccccgatg cctatagaca     3120

atggctcgac agtatttatg atgacgccga aatggacgaa cccgagtggg tcggaaatgg     3180

tatggataaa tttgaatccg cagaatgtga aaaacggttc aaagcacgga aggtcctcca     3240

gtgggctgag gagtattcat tgcaggataa cgacgaaacc atcttggctg tcactagaga     3300

cggcgaaatg tcccttccac tgcttcctta tgttcaaacc tcttctggga aacagcttct     3360

tgatggccag gtatatgagg acctgtccca cgaacaacag tacgaggcac ttgccttgaa     3420

ccgcgttaat gtacctttca cttggaaacg atcattttca gaggtcgtag atgaagatgg     3480

gctcctttgg ctggaaggca aacaaaacct ggatggatgg gtatggcagg gaaactctat     3540

tgtaataaca tacactggcg atgagggtat gacgagggtt ataccggcga atccgaaatc     3600

cgggtcaccc aaaaagaaga gaaaagtata ataacattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  466
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Forward oligo, J3 target sequence

<400>  466
atcatcctcc tgacaatttt gacagcccac atggcattcc acttatcact ggcatcttta       60

aaagccagga cggtc                                                        75


<210>  467
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Reverse oligo, J3 target sequence

<400>  467
gaccgtcctg gcttttaaag atgccagtga taagtggaat gccatgtggg ctgtcaaaat       60

tgtcaggagg atgat                                                        75


<210>  468
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: target strand J3

<400>  468
cgccgagctc gaattctttt gacagcccac atggcattcc acttatcact ggcatggatc       60

ctggctgtgg tgatg                                                        75


<210>  469
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: non target strand J3

<400>  469
catcaccaca gccaggatcc atgccagtga taagtggaat gccatgtggg ctgtcaaaag       60

aattcgagct cggcg                                                        75


<210>  470
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: target strand CCR5 Site

<400>  470
cgccgagctc gaattctttt taggtacctg gctgtcgtcc atgctgtgtt tgcatggatc       60

ctggctgtgg tgatg                                                        75


<210>  471
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: non target strand CCR5

<400>  471
catcaccaca gccaggatcc atgcaaacac agcatggacg acagccaggt acctaaaaag       60

aattcgagct cggcg                                                        75


<210>  472
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: target strand J3

<400>  472
cgccgagctc gaattctttt gacagcccac atggcattcc acttatcact ggcatggatc       60

ctggctgtgg tgatg                                                        75


<210>  473
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: non target strand J3

<400>  473
catcaccaca gccaggatcc atgccagtga taagtggaat gccatgtggg ctgtcaaaag       60

aattcgagct cggcg                                                        75


<210>  474
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: target strand CCR5 Site

<400>  474
cgccgagctc gaattctttt taggtacctg gctgtcgtcc atgctgtgtt tgcatggatc       60

ctggctgtgg tgatg                                                        75


<210>  475
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Forward primer to amplify Hsa07 dual-target from human
       genomic DNA

<400>  475
cactctttcc ctacacgacg ctcttccgat ctttcctccc taacctccac ct               52


<210>  476
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Reverse primer to amplify Hsa07 dual-target from human
       genomic DNA

<400>  476
ggagttcaga cgtgtgctct tccgatctta aagagcccaa ccagatgc                    48


<210>  477
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Forward oligo, J3 target sequence for cloning into 
       pACYC-Duet1

<400>  477
gatccatgcc agtgataagt ggaatgccat gtgggctgtc aaaag                       45


<210>  478
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Reverse oligo, J3 target sequence for cloning into 
       pACYC-Duet1

<400>  478
aattcttttg acagcccaca tggcattcca cttatcactg gcatg                       45


<210>  479
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Forward oligo, J3-15bp-L3 target sequences for cloning
       into pACYC-Duet1

<400>  479
aattcttttg acagcccaca tggcattcca cttatcactg gcatcctagg cctctcgaga       60

tgagtggcag atatagcctg gtggttcagg cggcgcatgc                            100


<210>  480
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Reverse oligo, J3-15bp-L3 target sequences for cloning
       into pACYC-Duet1

<400>  480
tcagcatgcg ccgcctgaac caccaggcta tatctgccac tcatctcgag aggcctagga       60

tgccagtgat aagtggaatg ccatgtgggc tgtcaaaag                              99


<210>  481
<211>  4068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3 target sequence in 
       pACYC-Duet1

<400>  481
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccat gccagtgata agtggaatgc catgtgggct gtcaaaagaa ttcgagctcg      180

gcgcgcctgc aggtcgacaa gcttgcggcc gcataatgct taagtcgaac agaaagtaat      240

cgtattgtac acggccgcat aatcgaaatt aatacgactc actatagggg aattgtgagc      300

ggataacaat tccccatctt agtatattag ttaagtataa gaaggagata tacatatggc      360

agatctcaat tggatatcgg ccggccacgc gatcgctgac gtcggtaccc tcgagtctgg      420

taaagaaacc gctgctgcga aatttgaacg ccagcacatg gactcgtcta ctagcgcagc      480

ttaattaacc taggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc      540

taaacgggtc ttgaggggtt ttttgctgaa acctcaggca tttgagaagc acacggtcac      600

actgcttccg gtagtcaata aaccggtaaa ccagcaatag acataagcgg ctatttaacg      660

accctgccct gaaccgacga ccgggtcgaa tttgctttcg aatttctgcc attcatccgc      720

ttattatcac ttattcaggc gtagcaccag gcgtttaagg gcaccaataa ctgccttaaa      780

aaaattacgc cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc      840

cgacatggaa gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct      900

tgtcgccttg cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat      960

tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca     1020

tattctcaat aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt     1080

gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa     1140

acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca     1200

gctcaccgtc tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa     1260

tgtgaataaa ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg     1320

taatatccag ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa     1380

aatgttcttt acgatgccat tgggatatat caacggtggt atatccagtg atttttttct     1440

ccattttagc ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg     1500

atcttatttc attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc     1560

gccaaaagtt ggcccagggc ttcccggtat caacagggac accaggattt atttattctg     1620

cgaagtgatc ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca     1680

acttactgat ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc     1740

agctgtccct cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga     1800

catcagcgct agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg     1860

aagtgcttca tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata     1920

caggatatat tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg     1980

agcggaaatg gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa     2040

cagggaagtg agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag     2100

catcacgaaa tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac     2160

caggcgtttc ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg     2220

gtgtcattcc gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg     2280

taggcagttc gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc     2340

gccttatccg gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg     2400

gcagcagcca ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg     2460

ctaaactgaa aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa     2520

agagttggta gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc     2580

agagcaagag attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat     2640

aaaatatttc tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc     2700

catacgatat aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg     2760

actgggttga aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa     2820

cttacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     2880

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt     2940

ggtttttctt ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg     3000

agagagttgc agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat     3060

ggtggttaac ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga     3120

gatgtccgca ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat     3180

ctgatcgttg gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt     3240

ttgttgaaaa ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg     3300

attgcgagtg agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa     3360

tgggcccgct aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag     3420

tcgcgtaccg tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc     3480

aagaaataac gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc     3540

cagcggatag ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc     3600

tttacaggct tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg     3660

atcggcgcga gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga     3720

ggtggcaacg ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg     3780

aatgtaattc agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg     3840

gctggcctgg ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac     3900

atcgtataac gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta     3960

tcatgccata ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc     4020

ccttatgtca gcattgcata ttgtcagacg actcctgcat taggaaat                  4068


<210>  482
<211>  3769
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-15bp-L3 target sequences 
       in pACYC-Duet1

<400>  482
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatcactgg catcctaggc      180

ctctcgagat gagtggcaga tatagcctgg tggttcaggc ggcgcatgct gagcaataac      240

tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgctg aaacctcagg      300

catttgagaa gcacacggtc acactgcttc cggtagtcaa taaaccggta aaccagcaat      360

agacataagc ggctatttaa cgaccctgcc ctgaaccgac gaccgggtcg aatttgcttt      420

cgaatttctg ccattcatcc gcttattatc acttattcag gcgtagcacc aggcgtttaa      480

gggcaccaat aactgcctta aaaaaattac gccccgccct gccactcatc gcagtactgt      540

tgtaattcat taagcattct gccgacatgg aagccatcac agacggcatg atgaacctga      600

atcgccagcg gcatcagcac cttgtcgcct tgcgtataat atttgcccat agtgaaaacg      660

ggggcgaaga agttgtccat attggccacg tttaaatcaa aactggtgaa actcacccag      720

ggattggctg agacgaaaaa catattctca ataaaccctt tagggaaata ggccaggttt      780

tcaccgtaac acgccacatc ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg      840

tattcactcc agagcgatga aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg      900

tgaacactat cccatatcac cagctcaccg tctttcattg ccatacggaa ctccggatga      960

gcattcatca ggcgggcaag aatgtgaata aaggccggat aaaacttgtg cttatttttc     1020

tttacggtct ttaaaaaggc cgtaatatcc agctgaacgg tctggttata ggtacattga     1080

gcaactgact gaaatgcctc aaaatgttct ttacgatgcc attgggatat atcaacggtg     1140

gtatatccag tgattttttt ctccatttta gcttccttag ctcctgaaaa tctcgataac     1200

tcaaaaaata cgcccggtag tgatcttatt tcattatggt gaaagttgga acctcttacg     1260

tgccgatcaa cgtctcattt tcgccaaaag ttggcccagg gcttcccggt atcaacaggg     1320

acaccaggat ttatttattc tgcgaagtga tcttccgtca caggtattta ttcggcgcaa     1380

agtgcgtcgg gtgatgctgc caacttactg atttagtgta tgatggtgtt tttgaggtgc     1440

tccagtggct tctgtttcta tcagctgtcc ctcctgttca gctactgacg gggtggtgcg     1500

taacggcaaa agcaccgccg gacatcagcg ctagcggagt gtatactggc ttactatgtt     1560

ggcactgatg agggtgtcag tgaagtgctt catgtggcag gagaaaaaag gctgcaccgg     1620

tgcgtcagca gaatatgtga tacaggatat attccgcttc ctcgctcact gactcgctac     1680

gctcggtcgt tcgactgcgg cgagcggaaa tggcttacga acggggcgga gatttcctgg     1740

aagatgccag gaagatactt aacagggaag tgagagggcc gcggcaaagc cgtttttcca     1800

taggctccgc ccccctgaca agcatcacga aatctgacgc tcaaatcagt ggtggcgaaa     1860

cccgacagga ctataaagat accaggcgtt tcccctggcg gctccctcgt gcgctctcct     1920

gttcctgcct ttcggtttac cggtgtcatt ccgctgttat ggccgcgttt gtctcattcc     1980

acgcctgaca ctcagttccg ggtaggcagt tcgctccaag ctggactgta tgcacgaacc     2040

ccccgttcag tccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccgga     2100

aagacatgca aaagcaccac tggcagcagc cactggtaat tgatttagag gagttagtct     2160

tgaagtcatg cgccggttaa ggctaaactg aaaggacaag ttttggtgac tgcgctcctc     2220

caagccagtt acctcggttc aaagagttgg tagctcagag aaccttcgaa aaaccgccct     2280

gcaaggcggt tttttcgttt tcagagcaag agattacgcg cagaccaaaa cgatctcaag     2340

aagatcatct tattaatcag ataaaatatt tctagatttc agtgcaattt atctcttcaa     2400

atgtagcacc tgaagtcagc cccatacgat ataagttgta attctcatgt tagtcatgcc     2460

ccgcgcccac cggaaggagc tgactgggtt gaaggctctc aagggcatcg gtcgagatcc     2520

cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgctcactgc ccgctttcca     2580

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     2640

tttgcgtatt gggcgccagg gtggtttttc ttttcaccag tgagacgggc aacagctgat     2700

tgcccttcac cgcctggccc tgagagagtt gcagcaagcg gtccacgctg gtttgcccca     2760

gcaggcgaaa atcctgtttg atggtggtta acggcgggat ataacatgag ctgtcttcgg     2820

tatcgtcgta tcccactacc gagatgtccg caccaacgcg cagcccggac tcggtaatgg     2880

cgcgcattgc gcccagcgcc atctgatcgt tggcaaccag catcgcagtg ggaacgatgc     2940

cctcattcag catttgcatg gtttgttgaa aaccggacat ggcactccag tcgccttccc     3000

gttccgctat cggctgaatt tgattgcgag tgagatattt atgccagcca gccagacgca     3060

gacgcgccga gacagaactt aatgggcccg ctaacagcgc gatttgctgg tgacccaatg     3120

cgaccagatg ctccacgccc agtcgcgtac cgtcttcatg ggagaaaata atactgttga     3180

tgggtgtctg gtcagagaca tcaagaaata acgccggaac attagtgcag gcagcttcca     3240

cagcaatggc atcctggtca tccagcggat agttaatgat cagcccactg acgcgttgcg     3300

cgagaagatt gtgcaccgcc gctttacagg cttcgacgcc gcttcgttct accatcgaca     3360

ccaccacgct ggcacccagt tgatcggcgc gagatttaat cgccgcgaca atttgcgacg     3420

gcgcgtgcag ggccagactg gaggtggcaa cgccaatcag caacgactgt ttgcccgcca     3480

gttgttgtgc cacgcggttg ggaatgtaat tcagctccgc catcgccgct tccacttttt     3540

cccgcgtttt cgcagaaacg tggctggcct ggttcaccac gcgggaaacg gtctgataag     3600

agacaccggc atactctgcg acatcgtata acgttactgg tttcacattc accaccctga     3660

attgactctc ttccgggcgc tatcatgcca taccgcgaaa ggttttgcgc cattcgatgg     3720

tgtccgggat ctcgacgctc tcccttatgc gactcctgca ttaggaaat                 3769


<210>  483
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target sequences 
       in pACYC-Duet1

<400>  483
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatcactgg catcctagcc      180

cttccactct ttcgaaactc gagatgagtg gcagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  484
<211>  5815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, multi-target plasmid

<400>  484
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcgagctc tctaggtacc tggctgtcgt ccatgctgtg tttgcatcct      180

aggcctctcg agcctaggcc tctcgagatg tgtgatcact tgggtggtgg ctgtgtttgc      240

gtgcttgaca gcccacatgg cattccactt atcactggca tcctagccct tccactcttt      300

cgaaactcga gatgagtggc agatatagcc tggtggttca ggcggcgcct gggcctgaaa      360

ggcctccagc tctgcctgcc cgcttactgc ctcagcttcc ctgccccaca aagggcctga      420

ggtgctgcct gggcatgtgt aaaggtgtcc aggcaaagcc actgaggtcc gggtgacagt      480

gcttcggcag gctgacagcc aggtgactga agtctgtgcg gcaacctaca tgatggggaa      540

tgagttgtgt gaattatggt ggtgctacaa acaagctcat ctttggaact ggcactctgc      600

ttgctgtcca gccaagtacg taagtagtgg catgtgtcag gtggattctg tatacaatta      660

tgtgtctgcc ggtccaaatg ccttcttcta taggccatgt ttttatttct cttccaaaag      720

agactccaga gccatccttg ggaagagtgc tgagatcact gtgggaattc aggaaacaca      780

cctcttgtct ttggaaaggg cacaagactt tctgtgattg caagtaagtg tttctagcca      840

tccttgattt tgatcagcca aggcaggatc ccaggagaca gagcagtagc cactttgagt      900

gaatttccca ggaggtgctc ctgccaaggc ccataccttc aaggaaaatt aaggcaaata      960

gaaaagactg tgtaacacca atgcaggcaa atcaaccttt ggggatggga ctacgctcac     1020

tgtgaagcca agtaagttgt gttcttcttt gcctaggcct tcagggacat caccaggttg     1080

tagaagttga caggcagtgc catgggggca acagccaaaa taggggggta atgatgtagg     1140

ggccaagcag tgcccagctg ggggtcaata gtttctgtca catcagctcc actttcagtg     1200

aaagcatcac ttgggattaa tatggggatg cagcattatg atgtgggtca aggaattaag     1260

ttagggaatg gcgaagccga aatgatcttt tcaagttaaa ttttatgcct tttatttctt     1320

aaacaaatgt atgattacat caaggcttca aaaatactca catggctatg ttttagcccc     1380

aacagagcca gaatgtgaaa agcaatttca gccttatttt attcccatca attgagaaac     1440

cattatgaag aagagagtcc atatttcaat ttccaagagc tgaggcaagg caaggctgct     1500

gcagcctccc ctggctgtgc acattccctc ctgctcccca gagactgcct ccgccatccc     1560

acagatgatg gatcttcagt gggttctctt gggctctagg tcccaaaagg ccacactggt     1620

gtgcctggcc acaggcttct accccgacca cgtggagctg agctggtggg tgaatgggaa     1680

ggaggtgcac agtggggtca gcacagaccc gcagctgtgc tccctcgctc cttcctctgc     1740

attgcccctc ttctccctct ccaaacagag ggaactctcc tacccccaag gaggtgaaag     1800

ctgctaccac ctctgtgccc ccccggcaat gccaacatat ctgggatcaa agctatctat     1860

ataaagtcct tgattctgtg tgggttcaaa cacatttcaa agcttcagga tcctgaaagg     1920

ttttgctcta cttcctgaag acctgaacac cgccctgcag gtcgacaagc ttgcggccgc     1980

ataatgctta agtcgaacag aaagtaatcg tattgtacac ggccgcataa tcgaaattaa     2040

tacgactcac tataggggaa ttgtgagcgg ataacaattc cccatcttag tatattagtt     2100

aagtataaga aggagatata catatggcag atctcaattg gatatcggcc ggccacgcga     2160

tcgctgacgt cggtaccctc gagtctggta aagaaaccgc tgctgcgaaa tttgaacgcc     2220

agcacatgga ctcgtctact agcgcagctt aattaaccta ggctgctgcc accgctgagc     2280

aataactagc ataacccctt ggggcctcta aacgggtctt gaggggtttt ttgctgaaac     2340

ctcaggcatt tgagaagcac acggtcacac tgcttccggt agtcaataaa ccggtaaacc     2400

agcaatagac ataagcggct atttaacgac cctgccctga accgacgacc gggtcgaatt     2460

tgctttcgaa tttctgccat tcatccgctt attatcactt attcaggcgt agcaccaggc     2520

gtttaagggc accaataact gccttaaaaa aattacgccc cgccctgcca ctcatcgcag     2580

tactgttgta attcattaag cattctgccg acatggaagc catcacagac ggcatgatga     2640

acctgaatcg ccagcggcat cagcaccttg tcgccttgcg tataatattt gcccatagtg     2700

aaaacggggg cgaagaagtt gtccatattg gccacgttta aatcaaaact ggtgaaactc     2760

acccagggat tggctgagac gaaaaacata ttctcaataa accctttagg gaaataggcc     2820

aggttttcac cgtaacacgc cacatcttgc gaatatatgt gtagaaactg ccggaaatcg     2880

tcgtggtatt cactccagag cgatgaaaac gtttcagttt gctcatggaa aacggtgtaa     2940

caagggtgaa cactatccca tatcaccagc tcaccgtctt tcattgccat acggaactcc     3000

ggatgagcat tcatcaggcg ggcaagaatg tgaataaagg ccggataaaa cttgtgctta     3060

tttttcttta cggtctttaa aaaggccgta atatccagct gaacggtctg gttataggta     3120

cattgagcaa ctgactgaaa tgcctcaaaa tgttctttac gatgccattg ggatatatca     3180

acggtggtat atccagtgat ttttttctcc attttagctt ccttagctcc tgaaaatctc     3240

gataactcaa aaaatacgcc cggtagtgat cttatttcat tatggtgaaa gttggaacct     3300

cttacgtgcc gatcaacgtc tcattttcgc caaaagttgg cccagggctt cccggtatca     3360

acagggacac caggatttat ttattctgcg aagtgatctt ccgtcacagg tatttattcg     3420

gcgcaaagtg cgtcgggtga tgctgccaac ttactgattt agtgtatgat ggtgtttttg     3480

aggtgctcca gtggcttctg tttctatcag ctgtccctcc tgttcagcta ctgacggggt     3540

ggtgcgtaac ggcaaaagca ccgccggaca tcagcgctag cggagtgtat actggcttac     3600

tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg tggcaggaga aaaaaggctg     3660

caccggtgcg tcagcagaat atgtgataca ggatatattc cgcttcctcg ctcactgact     3720

cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc ttacgaacgg ggcggagatt     3780

tcctggaaga tgccaggaag atacttaaca gggaagtgag agggccgcgg caaagccgtt     3840

tttccatagg ctccgccccc ctgacaagca tcacgaaatc tgacgctcaa atcagtggtg     3900

gcgaaacccg acaggactat aaagatacca ggcgtttccc ctggcggctc cctcgtgcgc     3960

tctcctgttc ctgcctttcg gtttaccggt gtcattccgc tgttatggcc gcgtttgtct     4020

cattccacgc ctgacactca gttccgggta ggcagttcgc tccaagctgg actgtatgca     4080

cgaacccccc gttcagtccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     4140

cccggaaaga catgcaaaag caccactggc agcagccact ggtaattgat ttagaggagt     4200

tagtcttgaa gtcatgcgcc ggttaaggct aaactgaaag gacaagtttt ggtgactgcg     4260

ctcctccaag ccagttacct cggttcaaag agttggtagc tcagagaacc ttcgaaaaac     4320

cgccctgcaa ggcggttttt tcgttttcag agcaagagat tacgcgcaga ccaaaacgat     4380

ctcaagaaga tcatcttatt aatcagataa aatatttcta gatttcagtg caatttatct     4440

cttcaaatgt agcacctgaa gtcagcccca tacgatataa gttgtaattc tcatgttagt     4500

catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg     4560

agatcccggt gcctaatgag tgagctaact tacattaatt gcgttgcgct cactgcccgc     4620

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     4680

aggcggtttg cgtattgggc gccagggtgg tttttctttt caccagtgag acgggcaaca     4740

gctgattgcc cttcaccgcc tggccctgag agagttgcag caagcggtcc acgctggttt     4800

gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg cgggatataa catgagctgt     4860

cttcggtatc gtcgtatccc actaccgaga tgtccgcacc aacgcgcagc ccggactcgg     4920

taatggcgcg cattgcgccc agcgccatct gatcgttggc aaccagcatc gcagtgggaa     4980

cgatgccctc attcagcatt tgcatggttt gttgaaaacc ggacatggca ctccagtcgc     5040

cttcccgttc cgctatcggc tgaatttgat tgcgagtgag atatttatgc cagccagcca     5100

gacgcagacg cgccgagaca gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac     5160

ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc ttcatgggag aaaataatac     5220

tgttgatggg tgtctggtca gagacatcaa gaaataacgc cggaacatta gtgcaggcag     5280

cttccacagc aatggcatcc tggtcatcca gcggatagtt aatgatcagc ccactgacgc     5340

gttgcgcgag aagattgtgc accgccgctt tacaggcttc gacgccgctt cgttctacca     5400

tcgacaccac cacgctggca cccagttgat cggcgcgaga tttaatcgcc gcgacaattt     5460

gcgacggcgc gtgcagggcc agactggagg tggcaacgcc aatcagcaac gactgtttgc     5520

ccgccagttg ttgtgccacg cggttgggaa tgtaattcag ctccgccatc gccgcttcca     5580

ctttttcccg cgttttcgca gaaacgtggc tggcctggtt caccacgcgg gaaacggtct     5640

gataagagac accggcatac tctgcgacat cgtataacgt tactggtttc acattcacca     5700

ccctgaattg actctcttcc gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt     5760

cgatggtgtc cgggatctcg acgctctccc ttatgcgact cctgcattag gaaat          5815


<210>  485
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa01

<400>  485
gggcctgaaa ggcctccagc tctgcctgcc cgcttactgc ctcagcttcc ctgccccaca       60

aagggcctga ggtgctgcct gggcatgtgt aaagg                                  95


<210>  486
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa02

<400>  486
caggcaaagc cactgaggtc cgggtgacag tgcttcggca ggctgacagc caggtgactg       60

aagtctgtgc ggcaacctac atgatgggga atgag                                  95


<210>  487
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa03

<400>  487
gtgaattatg gtggtgctac aaacaagctc atctttggaa ctggcactct gcttgctgtc       60

cagccaagta cgtaagtagt ggcatgtgtc aggtggattc                            100


<210>  488
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa04

<400>  488
tacaattatg tgtctgccgg tccaaatgcc ttcttctata ggccatgttt ttatttctct       60

tccaaaagag actccagagc catccttggg aagagtgctg                            100


<210>  489
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa05

<400>  489
cactgtggga attcaggaaa cacacctctt gtctttggaa agggcacaag actttctgtg       60

attgcaagta agtgtttcta gccatccttg attttgatca                            100


<210>  490
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa06

<400>  490
aggcaggatc ccaggagaca gagcagtagc cactttgagt gaatttccca ggaggtgctc       60

ctgccaaggc ccataccttc aaggaaaatt aaggcaaata                            100


<210>  491
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa07

<400>  491
agactgtgta acaccaatgc aggcaaatca acctttgggg atgggactac gctcactgtg       60

aagccaagta agttgtgttc ttctttgcct aggccttcag                            100


<210>  492
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa08

<400>  492
atcaccaggt tgtagaagtt gacaggcagt gccatggggg caacagccaa aatagggggg       60

taatgatgta ggggccaagc agtgcccagc tgggggtcaa                            100


<210>  493
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa09

<400>  493
ttctgtcaca tcagctccac tttcagtgaa agcatcactt gggattaata tggggatgca       60

gcattatgat gtgggtcaag gaattaagtt agggaatggc                            100


<210>  494
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa10

<400>  494
ccgaaatgat cttttcaagt taaattttat gccttttatt tcttaaacaa atgtatgatt       60

acatcaaggc ttcaaaaata ctcacatggc tatgttttag                            100


<210>  495
<211>  115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa11

<400>  495
tgctccctcg ctccttcctc tgcattgccc ctcttctccc tctccaaaca gagggaactc       60

tcctaccccc aaggaggtga aagctgctac cacctctgtg cccccccggc aatgc           115


<210>  496
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa12

<400>  496
aacagagcca gaatgtgaaa agcaatttca gccttatttt attcccatca attgagaaac       60

cattatgaag aagagagtcc atatttcaat ttccaagagc tgagg                      105


<210>  497
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa13

<400>  497
gcaaggctgc tgcagcctcc cctggctgtg cacattccct cctgctcccc agagactgcc       60

tccgccatcc cacagatgat ggatcttcag tgggttctct tgggctctag                 110


<210>  498
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa14

<400>  498
caaaaggcca cactggtgtg cctggccaca ggcttctacc ccgaccacgt ggagctgagc       60

tggtgggtga atgggaagga ggtgcacagt ggggtcagca cagacccgca                 110


<210>  499
<211>  115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa15

<400>  499
tgctccctcg ctccttcctc tgcattgccc ctcttctccc tctccaaaca gagggaactc       60

tcctaccccc aaggaggtga aagctgctac cacctctgtg cccccccggc aatgc           115


<210>  500
<211>  115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target Hsa16

<400>  500
atatctggga tcaaagctat ctatataaag tccttgattc tgtgtgggtt caaacacatt       60

tcaaagcttc aggatcctga aaggttttgc tctacttcct gaagacctga acacc           115


<210>  501
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: sgRNA-J3 spacer sequence

<400>  501
gugauaagug gaaugccaug u                                                 21


<210>  502
<211>  4008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, pACYC-Duet1 non-target 
       plasmid

<400>  502
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcgagctc ggcgcgcctg caggtcgaca agcttgcggc cgcataatgc      180

ttaagtcgaa cagaaagtaa tcgtattgta cacggccgca taatcgaaat taatacgact      240

cactataggg gaattgtgag cggataacaa ttccccatct tagtatatta gttaagtata      300

agaaggagat atacatatgg cagatctcaa ttggatatcg gccggccacg cgatcgctga      360

cgtcggtacc ctcgagtctg gtaaagaaac cgctgctgcg aaatttgaac gccagcacat      420

ggactcgtct actagcgcag cttaattaac ctaggctgct gccaccgctg agcaataact      480

agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgctga aacctcaggc      540

atttgagaag cacacggtca cactgcttcc ggtagtcaat aaaccggtaa accagcaata      600

gacataagcg gctatttaac gaccctgccc tgaaccgacg accgggtcga atttgctttc      660

gaatttctgc cattcatccg cttattatca cttattcagg cgtagcacca ggcgtttaag      720

ggcaccaata actgccttaa aaaaattacg ccccgccctg ccactcatcg cagtactgtt      780

gtaattcatt aagcattctg ccgacatgga agccatcaca gacggcatga tgaacctgaa      840

tcgccagcgg catcagcacc ttgtcgcctt gcgtataata tttgcccata gtgaaaacgg      900

gggcgaagaa gttgtccata ttggccacgt ttaaatcaaa actggtgaaa ctcacccagg      960

gattggctga gacgaaaaac atattctcaa taaacccttt agggaaatag gccaggtttt     1020

caccgtaaca cgccacatct tgcgaatata tgtgtagaaa ctgccggaaa tcgtcgtggt     1080

attcactcca gagcgatgaa aacgtttcag tttgctcatg gaaaacggtg taacaagggt     1140

gaacactatc ccatatcacc agctcaccgt ctttcattgc catacggaac tccggatgag     1200

cattcatcag gcgggcaaga atgtgaataa aggccggata aaacttgtgc ttatttttct     1260

ttacggtctt taaaaaggcc gtaatatcca gctgaacggt ctggttatag gtacattgag     1320

caactgactg aaatgcctca aaatgttctt tacgatgcca ttgggatata tcaacggtgg     1380

tatatccagt gatttttttc tccattttag cttccttagc tcctgaaaat ctcgataact     1440

caaaaaatac gcccggtagt gatcttattt cattatggtg aaagttggaa cctcttacgt     1500

gccgatcaac gtctcatttt cgccaaaagt tggcccaggg cttcccggta tcaacaggga     1560

caccaggatt tatttattct gcgaagtgat cttccgtcac aggtatttat tcggcgcaaa     1620

gtgcgtcggg tgatgctgcc aacttactga tttagtgtat gatggtgttt ttgaggtgct     1680

ccagtggctt ctgtttctat cagctgtccc tcctgttcag ctactgacgg ggtggtgcgt     1740

aacggcaaaa gcaccgccgg acatcagcgc tagcggagtg tatactggct tactatgttg     1800

gcactgatga gggtgtcagt gaagtgcttc atgtggcagg agaaaaaagg ctgcaccggt     1860

gcgtcagcag aatatgtgat acaggatata ttccgcttcc tcgctcactg actcgctacg     1920

ctcggtcgtt cgactgcggc gagcggaaat ggcttacgaa cggggcggag atttcctgga     1980

agatgccagg aagatactta acagggaagt gagagggccg cggcaaagcc gtttttccat     2040

aggctccgcc cccctgacaa gcatcacgaa atctgacgct caaatcagtg gtggcgaaac     2100

ccgacaggac tataaagata ccaggcgttt cccctggcgg ctccctcgtg cgctctcctg     2160

ttcctgcctt tcggtttacc ggtgtcattc cgctgttatg gccgcgtttg tctcattcca     2220

cgcctgacac tcagttccgg gtaggcagtt cgctccaagc tggactgtat gcacgaaccc     2280

cccgttcagt ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggaa     2340

agacatgcaa aagcaccact ggcagcagcc actggtaatt gatttagagg agttagtctt     2400

gaagtcatgc gccggttaag gctaaactga aaggacaagt tttggtgact gcgctcctcc     2460

aagccagtta cctcggttca aagagttggt agctcagaga accttcgaaa aaccgccctg     2520

caaggcggtt ttttcgtttt cagagcaaga gattacgcgc agaccaaaac gatctcaaga     2580

agatcatctt attaatcaga taaaatattt ctagatttca gtgcaattta tctcttcaaa     2640

tgtagcacct gaagtcagcc ccatacgata taagttgtaa ttctcatgtt agtcatgccc     2700

cgcgcccacc ggaaggagct gactgggttg aaggctctca agggcatcgg tcgagatccc     2760

ggtgcctaat gagtgagcta acttacatta attgcgttgc gctcactgcc cgctttccag     2820

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     2880

ttgcgtattg ggcgccaggg tggtttttct tttcaccagt gagacgggca acagctgatt     2940

gcccttcacc gcctggccct gagagagttg cagcaagcgg tccacgctgg tttgccccag     3000

caggcgaaaa tcctgtttga tggtggttaa cggcgggata taacatgagc tgtcttcggt     3060

atcgtcgtat cccactaccg agatgtccgc accaacgcgc agcccggact cggtaatggc     3120

gcgcattgcg cccagcgcca tctgatcgtt ggcaaccagc atcgcagtgg gaacgatgcc     3180

ctcattcagc atttgcatgg tttgttgaaa accggacatg gcactccagt cgccttcccg     3240

ttccgctatc ggctgaattt gattgcgagt gagatattta tgccagccag ccagacgcag     3300

acgcgccgag acagaactta atgggcccgc taacagcgcg atttgctggt gacccaatgc     3360

gaccagatgc tccacgccca gtcgcgtacc gtcttcatgg gagaaaataa tactgttgat     3420

gggtgtctgg tcagagacat caagaaataa cgccggaaca ttagtgcagg cagcttccac     3480

agcaatggca tcctggtcat ccagcggata gttaatgatc agcccactga cgcgttgcgc     3540

gagaagattg tgcaccgccg ctttacaggc ttcgacgccg cttcgttcta ccatcgacac     3600

caccacgctg gcacccagtt gatcggcgcg agatttaatc gccgcgacaa tttgcgacgg     3660

cgcgtgcagg gccagactgg aggtggcaac gccaatcagc aacgactgtt tgcccgccag     3720

ttgttgtgcc acgcggttgg gaatgtaatt cagctccgcc atcgccgctt ccactttttc     3780

ccgcgttttc gcagaaacgt ggctggcctg gttcaccacg cgggaaacgg tctgataaga     3840

gacaccggca tactctgcga catcgtataa cgttactggt ttcacattca ccaccctgaa     3900

ttgactctct tccgggcgct atcatgccat accgcgaaag gttttgcgcc attcgatggt     3960

gtccgggatc tcgacgctct cccttatgcg actcctgcat taggaaat                  4008


<210>  503
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target plasmid, 
       J3 PAM mutant

<400>  503
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatcactgg cggcctagcc      180

cttccactct ttcgaaactc gagatgagtg gcagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  504
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target plasmid, 
       L3 PAM mutant

<400>  504
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatcactgg catcctagcc      180

cttccactct ttcgaaactc gagccgagtg gcagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  505
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target plasmid, 
       J3/L3 PAM mutants

<400>  505
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatcactgg cggcctagcc      180

cttccactct ttcgaaactc gagccgagtg gcagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  506
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target plasmid, 
       J3 spacer mutant

<400>  506
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatgtgacc catcctagcc      180

cttccactct ttcgaaactc gagatgagtg gcagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  507
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target plasmid, 
       L3 spacer mutants

<400>  507
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatcactgg catcctagcc      180

cttccactct ttcgaaactc gagatgtcac cgagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  508
<211>  3784
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-30bp-L3 target plasmid, 
       J3/L3 spacer mutants

<400>  508
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccga attcttttga cagcccacat ggcattccac ttatgtgacc catcctagcc      180

cttccactct ttcgaaactc gagatgtcac cgagatatag cctggtggtt caggcggcgc      240

atgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt      300

tgctgaaacc tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaac      360

cggtaaacca gcaatagaca taagcggcta tttaacgacc ctgccctgaa ccgacgaccg      420

ggtcgaattt gctttcgaat ttctgccatt catccgctta ttatcactta ttcaggcgta      480

gcaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac      540

tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg      600

gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg      660

cccatagtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg      720

gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg      780

aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc      840

cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa      900

acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata      960

cggaactccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac     1020

ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg     1080

ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg     1140

gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct     1200

gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag     1260

ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc     1320

ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt     1380

atttattcgg cgcaaagtgc gtcgggtgat gctgccaact tactgattta gtgtatgatg     1440

gtgtttttga ggtgctccag tggcttctgt ttctatcagc tgtccctcct gttcagctac     1500

tgacggggtg gtgcgtaacg gcaaaagcac cgccggacat cagcgctagc ggagtgtata     1560

ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt ggcaggagaa     1620

aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc gcttcctcgc     1680

tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct tacgaacggg     1740

gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga gggccgcggc     1800

aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct gacgctcaaa     1860

tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc tggcggctcc     1920

ctcgtgcgct ctcctgttcc tgcctttcgg tttaccggtg tcattccgct gttatggccg     1980

cgtttgtctc attccacgcc tgacactcag ttccgggtag gcagttcgct ccaagctgga     2040

ctgtatgcac gaaccccccg ttcagtccga ccgctgcgcc ttatccggta actatcgtct     2100

tgagtccaac ccggaaagac atgcaaaagc accactggca gcagccactg gtaattgatt     2160

tagaggagtt agtcttgaag tcatgcgccg gttaaggcta aactgaaagg acaagttttg     2220

gtgactgcgc tcctccaagc cagttacctc ggttcaaaga gttggtagct cagagaacct     2280

tcgaaaaacc gccctgcaag gcggtttttt cgttttcaga gcaagagatt acgcgcagac     2340

caaaacgatc tcaagaagat catcttatta atcagataaa atatttctag atttcagtgc     2400

aatttatctc ttcaaatgta gcacctgaag tcagccccat acgatataag ttgtaattct     2460

catgttagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     2520

catcggtcga gatcccggtg cctaatgagt gagctaactt acattaattg cgttgcgctc     2580

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     2640

cgcggggaga ggcggtttgc gtattgggcg ccagggtggt ttttcttttc accagtgaga     2700

cgggcaacag ctgattgccc ttcaccgcct ggccctgaga gagttgcagc aagcggtcca     2760

cgctggtttg ccccagcagg cgaaaatcct gtttgatggt ggttaacggc gggatataac     2820

atgagctgtc ttcggtatcg tcgtatccca ctaccgagat gtccgcacca acgcgcagcc     2880

cggactcggt aatggcgcgc attgcgccca gcgccatctg atcgttggca accagcatcg     2940

cagtgggaac gatgccctca ttcagcattt gcatggtttg ttgaaaaccg gacatggcac     3000

tccagtcgcc ttcccgttcc gctatcggct gaatttgatt gcgagtgaga tatttatgcc     3060

agccagccag acgcagacgc gccgagacag aacttaatgg gcccgctaac agcgcgattt     3120

gctggtgacc caatgcgacc agatgctcca cgcccagtcg cgtaccgtct tcatgggaga     3180

aaataatact gttgatgggt gtctggtcag agacatcaag aaataacgcc ggaacattag     3240

tgcaggcagc ttccacagca atggcatcct ggtcatccag cggatagtta atgatcagcc     3300

cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg acgccgcttc     3360

gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat ttaatcgccg     3420

cgacaatttg cgacggcgcg tgcagggcca gactggaggt ggcaacgcca atcagcaacg     3480

actgtttgcc cgccagttgt tgtgccacgc ggttgggaat gtaattcagc tccgccatcg     3540

ccgcttccac tttttcccgc gttttcgcag aaacgtggct ggcctggttc accacgcggg     3600

aaacggtctg ataagagaca ccggcatact ctgcgacatc gtataacgtt actggtttca     3660

cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg cgaaaggttt     3720

tgcgccattc gatggtgtcc gggatctcga cgctctccct tatgcgactc ctgcattagg     3780

aaat                                                                  3784


<210>  509
<211>  4068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, J3-only target plasmid

<400>  509
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccat gccagtgata agtggaatgc catgtgggct gtcaaaagaa ttcgagctcg      180

gcgcgcctgc aggtcgacaa gcttgcggcc gcataatgct taagtcgaac agaaagtaat      240

cgtattgtac acggccgcat aatcgaaatt aatacgactc actatagggg aattgtgagc      300

ggataacaat tccccatctt agtatattag ttaagtataa gaaggagata tacatatggc      360

agatctcaat tggatatcgg ccggccacgc gatcgctgac gtcggtaccc tcgagtctgg      420

taaagaaacc gctgctgcga aatttgaacg ccagcacatg gactcgtcta ctagcgcagc      480

ttaattaacc taggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc      540

taaacgggtc ttgaggggtt ttttgctgaa acctcaggca tttgagaagc acacggtcac      600

actgcttccg gtagtcaata aaccggtaaa ccagcaatag acataagcgg ctatttaacg      660

accctgccct gaaccgacga ccgggtcgaa tttgctttcg aatttctgcc attcatccgc      720

ttattatcac ttattcaggc gtagcaccag gcgtttaagg gcaccaataa ctgccttaaa      780

aaaattacgc cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc      840

cgacatggaa gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct      900

tgtcgccttg cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat      960

tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca     1020

tattctcaat aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt     1080

gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa     1140

acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca     1200

gctcaccgtc tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa     1260

tgtgaataaa ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg     1320

taatatccag ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa     1380

aatgttcttt acgatgccat tgggatatat caacggtggt atatccagtg atttttttct     1440

ccattttagc ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg     1500

atcttatttc attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc     1560

gccaaaagtt ggcccagggc ttcccggtat caacagggac accaggattt atttattctg     1620

cgaagtgatc ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca     1680

acttactgat ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc     1740

agctgtccct cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga     1800

catcagcgct agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg     1860

aagtgcttca tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata     1920

caggatatat tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg     1980

agcggaaatg gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa     2040

cagggaagtg agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag     2100

catcacgaaa tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac     2160

caggcgtttc ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg     2220

gtgtcattcc gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg     2280

taggcagttc gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc     2340

gccttatccg gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg     2400

gcagcagcca ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg     2460

ctaaactgaa aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa     2520

agagttggta gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc     2580

agagcaagag attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat     2640

aaaatatttc tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc     2700

catacgatat aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg     2760

actgggttga aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa     2820

cttacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     2880

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt     2940

ggtttttctt ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg     3000

agagagttgc agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat     3060

ggtggttaac ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga     3120

gatgtccgca ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat     3180

ctgatcgttg gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt     3240

ttgttgaaaa ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg     3300

attgcgagtg agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa     3360

tgggcccgct aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag     3420

tcgcgtaccg tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc     3480

aagaaataac gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc     3540

cagcggatag ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc     3600

tttacaggct tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg     3660

atcggcgcga gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga     3720

ggtggcaacg ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg     3780

aatgtaattc agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg     3840

gctggcctgg ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac     3900

atcgtataac gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta     3960

tcatgccata ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc     4020

ccttatgtca gcattgcata ttgtcagacg actcctgcat taggaaat                  4068


<210>  510
<211>  4047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Complete vector sequence, L3-only target plasmid

<400>  510
taatacgact cactataggg gaattgtgag cggataacaa ttcccctgta gaaataattt       60

tgtttaactt taataaggag atataccatg ggcagcagcc atcaccatca tcaccacagc      120

caggatccat gcgccgcctg aaccaccagg ctatatctgc cactcatgaa ttcgagctcg      180

gcgcgcctgc aggtcgacaa gcttgcggcc gcataatgct taagtcgaac agaaagtaat      240

cgtattgtac acggccgcat aatcgaaatt aatacgactc actatagggg aattgtgagc      300

ggataacaat tccccatctt agtatattag ttaagtataa gaaggagata tacatatggc      360

agatctcaat tggatatcgg ccggccacgc gatcgctgac gtcggtaccc tcgagtctgg      420

taaagaaacc gctgctgcga aatttgaacg ccagcacatg gactcgtcta ctagcgcagc      480

ttaattaacc taggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc      540

taaacgggtc ttgaggggtt ttttgctgaa acctcaggca tttgagaagc acacggtcac      600

actgcttccg gtagtcaata aaccggtaaa ccagcaatag acataagcgg ctatttaacg      660

accctgccct gaaccgacga ccgggtcgaa tttgctttcg aatttctgcc attcatccgc      720

ttattatcac ttattcaggc gtagcaccag gcgtttaagg gcaccaataa ctgccttaaa      780

aaaattacgc cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc      840

cgacatggaa gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct      900

tgtcgccttg cgtataatat ttgcccatag tgaaaacggg ggcgaagaag ttgtccatat      960

tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca     1020

tattctcaat aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt     1080

gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa     1140

acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca     1200

gctcaccgtc tttcattgcc atacggaact ccggatgagc attcatcagg cgggcaagaa     1260

tgtgaataaa ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg     1320

taatatccag ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa     1380

aatgttcttt acgatgccat tgggatatat caacggtggt atatccagtg atttttttct     1440

ccattttagc ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg     1500

atcttatttc attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc     1560

gccaaaagtt ggcccagggc ttcccggtat caacagggac accaggattt atttattctg     1620

cgaagtgatc ttccgtcaca ggtatttatt cggcgcaaag tgcgtcgggt gatgctgcca     1680

acttactgat ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc     1740

agctgtccct cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga     1800

catcagcgct agcggagtgt atactggctt actatgttgg cactgatgag ggtgtcagtg     1860

aagtgcttca tgtggcagga gaaaaaaggc tgcaccggtg cgtcagcaga atatgtgata     1920

caggatatat tccgcttcct cgctcactga ctcgctacgc tcggtcgttc gactgcggcg     1980

agcggaaatg gcttacgaac ggggcggaga tttcctggaa gatgccagga agatacttaa     2040

cagggaagtg agagggccgc ggcaaagccg tttttccata ggctccgccc ccctgacaag     2100

catcacgaaa tctgacgctc aaatcagtgg tggcgaaacc cgacaggact ataaagatac     2160

caggcgtttc ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg     2220

gtgtcattcc gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg     2280

taggcagttc gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc     2340

gccttatccg gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg     2400

gcagcagcca ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg     2460

ctaaactgaa aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa     2520

agagttggta gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc     2580

agagcaagag attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat     2640

aaaatatttc tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc     2700

catacgatat aagttgtaat tctcatgtta gtcatgcccc gcgcccaccg gaaggagctg     2760

actgggttga aggctctcaa gggcatcggt cgagatcccg gtgcctaatg agtgagctaa     2820

cttacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     2880

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgccagggt     2940

ggtttttctt ttcaccagtg agacgggcaa cagctgattg cccttcaccg cctggccctg     3000

agagagttgc agcaagcggt ccacgctggt ttgccccagc aggcgaaaat cctgtttgat     3060

ggtggttaac ggcgggatat aacatgagct gtcttcggta tcgtcgtatc ccactaccga     3120

gatgtccgca ccaacgcgca gcccggactc ggtaatggcg cgcattgcgc ccagcgccat     3180

ctgatcgttg gcaaccagca tcgcagtggg aacgatgccc tcattcagca tttgcatggt     3240

ttgttgaaaa ccggacatgg cactccagtc gccttcccgt tccgctatcg gctgaatttg     3300

attgcgagtg agatatttat gccagccagc cagacgcaga cgcgccgaga cagaacttaa     3360

tgggcccgct aacagcgcga tttgctggtg acccaatgcg accagatgct ccacgcccag     3420

tcgcgtaccg tcttcatggg agaaaataat actgttgatg ggtgtctggt cagagacatc     3480

aagaaataac gccggaacat tagtgcaggc agcttccaca gcaatggcat cctggtcatc     3540

cagcggatag ttaatgatca gcccactgac gcgttgcgcg agaagattgt gcaccgccgc     3600

tttacaggct tcgacgccgc ttcgttctac catcgacacc accacgctgg cacccagttg     3660

atcggcgcga gatttaatcg ccgcgacaat ttgcgacggc gcgtgcaggg ccagactgga     3720

ggtggcaacg ccaatcagca acgactgttt gcccgccagt tgttgtgcca cgcggttggg     3780

aatgtaattc agctccgcca tcgccgcttc cactttttcc cgcgttttcg cagaaacgtg     3840

gctggcctgg ttcaccacgc gggaaacggt ctgataagag acaccggcat actctgcgac     3900

atcgtataac gttactggtt tcacattcac caccctgaat tgactctctt ccgggcgcta     3960

tcatgccata ccgcgaaagg ttttgcgcca ttcgatggtg tccgggatct cgacgctctc     4020

ccttatgcga ctcctgcatt aggaaat                                         4047


<210>  511
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa01-1

<400>  511
auaaaccgcg ggcaggcaga gcuggaggcc uuucaggccc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  512
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa01-2

<400>  512
auaaaccggg ccugaggugc ugccugggca uguguaaagg gaguuccccg cgccagcggg       60

g                                                                       61


<210>  513
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa02-1

<400>  513
auaaaccgca cugucacccg gaccucagug gcuuugccug gaguuccccg cgccagcggg       60

g                                                                       61


<210>  514
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa02-2

<400>  514
auaaaccguc ugugcggcaa ccuacaugau ggggaaugag gaguuccccg cgccagcggg       60

g                                                                       61


<210>  515
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa03-1

<400>  515
auaaaccgau gagcuuguuu guagcaccac cauaauucac gaguuccccg cgccagcggg       60

g                                                                       61


<210>  516
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa03-2

<400>  516
auaaaccgua cguaaguagu ggcauguguc agguggauuc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  517
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa04-1

<400>  517
auaaaccgaa ggcauuugga ccggcagaca cauaauugua gaguuccccg cgccagcggg       60

g                                                                       61


<210>  518
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa04-2

<400>  518
auaaaccgag acuccagagc cauccuuggg aagagugcug gaguuccccg cgccagcggg       60

g                                                                       61


<210>  519
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa05-1

<400>  519
auaaaccgac aagaggugug uuuccugaau ucccacagug gaguuccccg cgccagcggg       60

g                                                                       61


<210>  520
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa05-2

<400>  520
auaaaccgua aguguuucua gccauccuug auuuugauca gaguuccccg cgccagcggg       60

g                                                                       61


<210>  521
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa06-1

<400>  521
auaaaccgug gcuacugcuc ugucuccugg gauccugccu gaguuccccg cgccagcggg       60

g                                                                       61


<210>  522
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa06-2

<400>  522
auaaaccggc ccauaccuuc aaggaaaauu aaggcaaaua gaguuccccg cgccagcggg       60

g                                                                       61


<210>  523
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa07-1

<400>  523
auaaaccggu ugauuugccu gcauuggugu uacacagucu gaguuccccg cgccagcggg       60

g                                                                       61


<210>  524
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa07-2

<400>  524
auaaaccgua aguuguguuc uucuuugccu aggccuucag gaguuccccg cgccagcggg       60

g                                                                       61


<210>  525
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa08-1

<400>  525
auaaaccggc acugccuguc aacuucuaca accuggugau gaguuccccg cgccagcggg       60

g                                                                       61


<210>  526
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa08-2

<400>  526
auaaaccgua ggggccaagc agugcccagc ugggggucaa gaguuccccg cgccagcggg       60

g                                                                       61


<210>  527
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa09-1

<400>  527
auaaaccgcu uucacugaaa guggagcuga ugugacagaa gaguuccccg cgccagcggg       60

g                                                                       61


<210>  528
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa09-2

<400>  528
auaaaccgau gugggucaag gaauuaaguu agggaauggc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  529
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa10-1

<400>  529
auaaaccggc auaaaauuua acuugaaaag aucauuucgg gaguuccccg cgccagcggg       60

g                                                                       61


<210>  530
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa10-2

<400>  530
auaaaccggc uucaaaaaua cucacauggc uauguuuuag gaguuccccg cgccagcggg       60

g                                                                       61


<210>  531
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa11-1

<400>  531
auaaaccgag gggcaaugca gaggaaggag cgagggagca gaguuccccg cgccagcggg       60

g                                                                       61


<210>  532
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa11-2

<400>  532
auaaaccgga ggugaaagcu gcuaccaccu cugugccccc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  533
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa12-1

<400>  533
auaaaccggc ugaaauugcu uuucacauuc uggcucuguu gaguuccccg cgccagcggg       60

g                                                                       61


<210>  534
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa12-2

<400>  534
auaaaccgag aguccauauu ucaauuucca agagcugagg gaguuccccg cgccagcggg       60

g                                                                       61


<210>  535
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa13-1

<400>  535
auaaaccgug cacagccagg ggaggcugca gcagccuugc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  536
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa13-2

<400>  536
auaaaccgau ggaucuucag uggguucucu ugggcucuag gaguuccccg cgccagcggg       60

g                                                                       61


<210>  537
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa14-1

<400>  537
auaaaccgcc uguggccagg cacaccagug uggccuuuug gaguuccccg cgccagcggg       60

g                                                                       61


<210>  538
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa14-2

<400>  538
auaaaccgga ggugcacagu ggggucagca cagacccgca gaguuccccg cgccagcggg       60

g                                                                       61


<210>  539
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa15-1

<400>  539
auaaaccgag gggcaaugca gaggaaggag cgagggagca gaguuccccg cgccagcggg       60

g                                                                       61


<210>  540
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa15-2

<400>  540
auaaaccgcu gcuaccaccu cugugccccc ccggcaaugc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  541
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa16-1

<400>  541
auaaaccgga cuuuauauag auagcuuuga ucccagauau gaguuccccg cgccagcggg       60

g                                                                       61


<210>  542
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: crRNA sequence, target Hsa16-2

<400>  542
auaaaccggu uuugcucuac uuccugaaga ccugaacacc gaguuccccg cgccagcggg       60

g                                                                       61


<210>  543
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo A

<400>  543
accgatgagc ttgtttgtag caccaccata attcacgagt tccccgcgcc agcggggata       60

aaccgtacgt aagtagtggc atgtgtcagg tggattc                                97


<210>  544
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo B

<400>  544
actcgaatcc acctgacaca tgccactact tacgtacggt ttatccccgc tggcgcgggg       60

aactcgtgaa ttatggtggt gctacaaaca agctcat                                97


<210>  545
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo C

<400>  545
accgaaggca tttggaccgg cagacacata attgtagagt tccccgcgcc agcggggata       60

aaccgagact ccagagccat ccttgggaag agtgctg                                97


<210>  546
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo D

<400>  546
actccagcac tcttcccaag gatggctctg gagtctcggt ttatccccgc tggcgcgggg       60

aactctacaa ttatgtgtct gccggtccaa atgcctt                                97


<210>  547
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo E

<400>  547
accgacaaga ggtgtgtttc ctgaattccc acagtggagt tccccgcgcc agcggggata       60

aaccgtaagt gtttctagcc atccttgatt ttgatca                                97


<210>  548
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo F

<400>  548
actctgatca aaatcaagga tggctagaaa cacttacggt ttatccccgc tggcgcgggg       60

aactccactg tgggaattca ggaaacacac ctcttgt                                97


<210>  549
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo G

<400>  549
accgtggcta ctgctctgtc tcctgggatc ctgcctgagt tccccgcgcc agcggggata       60

aaccggccca taccttcaag gaaaattaag gcaaata                                97


<210>  550
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo H

<400>  550
actctatttg ccttaatttt ccttgaaggt atgggccggt ttatccccgc tggcgcgggg       60

aactcaggca ggatcccagg agacagagca gtagcca                                97


<210>  551
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo I

<400>  551
accggttgat ttgcctgcat tggtgttaca cagtctgagt tccccgcgcc agcggggata       60

aaccgtaagt tgtgttcttc tttgcctagg ccttcag                                97


<210>  552
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo J

<400>  552
actcctgaag gcctaggcaa agaagaacac aacttacggt ttatccccgc tggcgcgggg       60

aactcagact gtgtaacacc aatgcaggca aatcaac                                97


<210>  553
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo K

<400>  553
accggcactg cctgtcaact tctacaacct ggtgatgagt tccccgcgcc agcggggata       60

aaccgtaggg gccaagcagt gcccagctgg gggtcaa                                97


<210>  554
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo L

<400>  554
actcttgacc cccagctggg cactgcttgg cccctacggt ttatccccgc tggcgcgggg       60

aactcatcac caggttgtag aagttgacag gcagtgc                                97


<210>  555
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo M

<400>  555
accgctttca ctgaaagtgg agctgatgtg acagaagagt tccccgcgcc agcggggata       60

aaccgatgtg ggtcaaggaa ttaagttagg gaatggc                                97


<210>  556
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo N

<400>  556
actcgccatt ccctaactta attccttgac ccacatcggt ttatccccgc tggcgcgggg       60

aactcttctg tcacatcagc tccactttca gtgaaag                                97


<210>  557
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo O

<400>  557
accggcataa aatttaactt gaaaagatca tttcgggagt tccccgcgcc agcggggata       60

aaccggcttc aaaaatactc acatggctat gttttag                                97


<210>  558
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo P

<400>  558
actcctaaaa catagccatg tgagtatttt tgaagccggt ttatccccgc tggcgcgggg       60

aactcccgaa atgatctttt caagttaaat tttatgc                                97


<210>  559
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo Q

<400>  559
cactctttcc ctacacgacg ctcttccgat ctagcctgga aagacacaaa gc               52


<210>  560
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo R

<400>  560
ggagttcaga cgtgtgctct tccgatctca gccatccttt ccacctaa                    48


<210>  561
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo S

<400>  561
cactctttcc ctacacgacg ctcttccgat ctatgctgca ggctttatgc tt               52


<210>  562
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo T

<400>  562
ggagttcaga cgtgtgctct tccgatcttt aggcctgcct gacttctc                    48


<210>  563
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo U

<400>  563
cactctttcc ctacacgacg ctcttccgat ctgggaagaa gaccaacaag agg              53


<210>  564
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo V

<400>  564
ggagttcaga cgtgtgctct tccgatcttt caagggaaga agccattg                    48


<210>  565
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo W

<400>  565
cactctttcc ctacacgacg ctcttccgat ctaaggcagg aattggatga aa               52


<210>  566
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo X

<400>  566
ggagttcaga cgtgtgctct tccgatctaa cctgagatga ctgcccat                    48


<210>  567
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo Y

<400>  567
cactctttcc ctacacgacg ctcttccgat ctttcctccc taacctccac ct               52


<210>  568
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo Z

<400>  568
ggagttcaga cgtgtgctct tccgatctta aagagcccaa ccagatgc                    48


<210>  569
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo A2

<400>  569
cactctttcc ctacacgacg ctcttccgat ctgtctcagc cttagccctg tg               52


<210>  570
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo B2

<400>  570
ggagttcaga cgtgtgctct tccgatctcc cactgcaagt acaagggt                    48


<210>  571
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo C2

<400>  571
cactctttcc ctacacgacg ctcttccgat ctggatgcgg aacccaaatt a                51


<210>  572
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo D2

<400>  572
ggagttcaga cgtgtgctct tccgatctta gtcttctccc tcgctccc                    48


<210>  573
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo E2

<400>  573
cactctttcc ctacacgacg ctcttccgat cttgcagcat tatgatgtgg gt               52


<210>  574
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo F2

<400>  574
ggagttcaga cgtgtgctct tccgatctca acctttagca tcactggct                   49


<210>  575
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo G2


<220>
<221>  misc_feature
<222>  (25)..(32)
<223>  n is a, c, g, or t

<400>  575
caagcagaag acggcatacg agatnnnnnn nngtgactgg agttcagacg tgtgctc          57


<210>  576
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Oligo H2


<220>
<221>  misc_feature
<222>  (30)..(37)
<223>  n is a, c, g, or t

<400>  576
aatgatacgg cgaccaccga gatctacacn nnnnnnnaca ctctttccct acacgacg         58


<210>  577
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NSL-Cas6

<400>  577

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Met Tyr Leu Ser Lys 
1               5                   10                  15      


Val Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu Tyr Gln Leu His Gln 
            20                  25                  30          


Gly Leu Trp His Leu Phe Pro Asn Arg Pro Asp Ala Ala Arg Asp Phe 
        35                  40                  45              


Leu Phe His Val Glu Lys Arg Asn Thr Pro Glu Gly Cys His Val Leu 
    50                  55                  60                  


Leu Gln Ser Ala Gln Met Pro Val Ser Thr Ala Val Ala Thr Val Ile 
65                  70                  75                  80  


Lys Thr Lys Gln Val Glu Phe Gln Leu Gln Val Gly Val Pro Leu Tyr 
                85                  90                  95      


Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile Leu Asp Asn Gln Lys 
            100                 105                 110         


Arg Leu Asp Ser Lys Gly Asn Ile Lys Arg Cys Arg Val Pro Leu Ile 
        115                 120                 125             


Lys Glu Ala Glu Gln Ile Ala Trp Leu Gln Arg Lys Leu Gly Asn Ala 
    130                 135                 140                 


Ala Arg Val Glu Asp Val His Pro Ile Ser Glu Arg Pro Gln Tyr Phe 
145                 150                 155                 160 


Ser Gly Asp Gly Lys Ser Gly Lys Ile Gln Thr Val Cys Phe Glu Gly 
                165                 170                 175     


Val Leu Thr Ile Asn Asp Ala Pro Ala Leu Ile Asp Leu Val Gln Gln 
            180                 185                 190         


Gly Ile Gly Pro Ala Lys Ser Met Gly Cys Gly Leu Leu Ser Leu Ala 
        195                 200                 205             


Pro Leu 
    210 


<210>  578
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cpCas7 V1

<400>  578

Met Lys Asp Gly Phe Leu Gln Pro Ser Ile Gln Ala Phe Asn Gln Tyr 
1               5                   10                  15      


Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu Asn Gly Ala Ala Ala Gln 
            20                  25                  30          


Phe Ser Leu Ser Asp Val Asp Pro Ile Thr Ala Gln Val Lys Gln Met 
        35                  40                  45              


Pro Thr Leu Glu Gln Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala 
    50                  55                  60                  


Gly Ser Met Ser Asn Phe Ile Asn Ile His Val Leu Ile Ser His Ser 
65                  70                  75                  80  


Pro Ser Cys Leu Asn Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile 
                85                  90                  95      


Phe Gly Gly Lys Arg Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg 
            100                 105                 110         


Ala Met Arg Lys Ser Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser 
        115                 120                 125             


Leu Arg Thr Ile His Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys 
    130                 135                 140                 


Leu Gly Glu Arg Phe Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu 
145                 150                 155                 160 


Leu Ser Gly Lys Ser Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala 
                165                 170                 175     


Val Thr Pro Trp Val Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val 
            180                 185                 190         


Ala Lys Ala Glu Ala Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val 
        195                 200                 205             


Leu Lys Glu Asp Ile Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val 
    210                 215                 220                 


Asp Ile Ala Leu Ser Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu 
225                 230                 235                 240 


Leu Gly Lys Val Asp Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr 
                245                 250                 255     


His Gln Val Asp Ser Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu 
            260                 265                 270         


Gln Glu Gln Gly Ser Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly 
        275                 280                 285             


Val Phe Tyr Arg Tyr Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn 
    290                 295                 300                 


Leu Gly Gly Ala Ser Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val 
305                 310                 315                 320 


Val His Met Leu Ala Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr 
                325                 330                 335     


Ala Ala Phe Asn Pro Ala Asp Met Val Met Val Asn Phe Ser Asp Met 
            340                 345                 350         


Pro Leu Ser Met Ala Asn Ala Phe Glu Lys Ala Val Lys Ala 
        355                 360                 365     


<210>  579
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cpCas7 V2

<400>  579

Met Asp Pro Ile Thr Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln 
1               5                   10                  15      


Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala Gly Ser Met Ser Asn 
            20                  25                  30          


Phe Ile Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn 
        35                  40                  45              


Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg 
    50                  55                  60                  


Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser 
65                  70                  75                  80  


Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His 
                85                  90                  95      


Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe 
            100                 105                 110         


Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser 
        115                 120                 125             


Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val 
    130                 135                 140                 


Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile 
                165                 170                 175     


Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser 
            180                 185                 190         


Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp 
        195                 200                 205             


Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser 
    210                 215                 220                 


Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser 
225                 230                 235                 240 


Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr 
                245                 250                 255     


Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser 
            260                 265                 270         


Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala 
        275                 280                 285             


Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro 
    290                 295                 300                 


Ala Asp Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala 
305                 310                 315                 320 


Asn Ala Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro 
                325                 330                 335     


Ser Ile Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr 
            340                 345                 350         


Gly Leu Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val 
        355                 360                 365     


<210>  580
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Fok1

<400>  580

Met Phe Leu Ser Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln 
1               5                   10                  15      


Asn Pro Gly Lys Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp 
            20                  25                  30          


Arg Asn Ser Lys Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr 
        35                  40                  45              


Leu Val Lys Glu Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn 
    50                  55                  60                  


Gln His Asp Leu Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr 
65                  70                  75                  80  


Ser Ile Arg Ser Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile 
                85                  90                  95      


Ala Asp Gln Gly Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp 
            100                 105                 110         


Gly Phe Leu Arg Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn 
        115                 120                 125             


Lys Ser Asp Ser Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys 
    130                 135                 140                 


Ser Ala Asp Gly Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Ser Ser Tyr Pro Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly 
                165                 170                 175     


Gln His Leu Thr Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly 
            180                 185                 190         


Glu Ser Gly Phe Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu 
        195                 200                 205             


Ala Asn Ala Met Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu 
    210                 215                 220                 


Gly Ser Ser Asp Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys 
225                 230                 235                 240 


Leu Gly Leu Val Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu 
                245                 250                 255     


Gly Lys Pro Asp Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr 
            260                 265                 270         


Gly Glu Gly Leu Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe 
        275                 280                 285             


Thr Arg Val Pro Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu 
    290                 295                 300                 


Thr Asp Lys Glu Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile 
305                 310                 315                 320 


Leu Ile Lys Ala Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu 
                325                 330                 335     


Lys Lys Leu Gly Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile 
            340                 345                 350         


Lys Gly Leu Ile Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe 
        355                 360                 365             


Tyr Gln Leu Lys Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly 
    370                 375                 380                 


Val Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu 
385                 390                 395                 400 


Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile 
                405                 410                 415     


Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val 
            420                 425                 430         


Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly 
        435                 440                 445             


Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile 
    450                 455                 460                 


Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn 
465                 470                 475                 480 


Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn 
                485                 490                 495     


Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr 
            500                 505                 510         


Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe 
        515                 520                 525             


Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn 
    530                 535                 540                 


Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu 
545                 550                 555                 560 


Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe 
                565                 570                 575     


Asn Asn Gly Glu Ile Asn Phe 
            580             


<210>  581
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Fok1 sharkey

<400>  581

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  582
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  582

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly 
            20                  25                  30  


<210>  583
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexahistidine tag

<400>  583

His His His His His His 
1               5       


<210>  584
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MBP

<400>  584

Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365         


<210>  585
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: TEV

<400>  585

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  586
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS

<400>  586

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  587
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Fok1_Linker-Cas8

<400>  587

Ser Asn Met Pro Lys Lys Lys Arg Lys Val Gln Leu Val Lys Ser Glu 
1               5                   10                  15      


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
            20                  25                  30          


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp 
        35                  40                  45              


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
    50                  55                  60                  


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
65                  70                  75                  80  


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
                85                  90                  95      


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
            100                 105                 110         


Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
        115                 120                 125             


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
    130                 135                 140                 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
145                 150                 155                 160 


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
                165                 170                 175     


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
            180                 185                 190         


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly 
        195                 200                 205             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Gly 
    210                 215                 220                 


Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Met Asn Leu Leu 
225                 230                 235                 240 


Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly Gly Lys Val Gln 
                245                 250                 255     


Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp Gln Trp Arg Leu 
            260                 265                 270         


Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu Ala Leu Leu Val 
        275                 280                 285             


Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp Val Glu Phe Arg 
    290                 295                 300                 


His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe Gln Gln Leu Ile 
305                 310                 315                 320 


Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala Glu His Pro Phe 
                325                 330                 335     


Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr Pro Met Glu Lys 
            340                 345                 350         


Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala Phe Val Asn Gln 
        355                 360                 365             


Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr Ala Ile Ala Leu 
    370                 375                 380                 


Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly Gly Phe Lys Ser 
385                 390                 395                 400 


Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val Arg Gly Ile Asp 
                405                 410                 415     


Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu Pro Arg Leu Gln 
            420                 425                 430         


Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln Pro Thr Trp Ile 
        435                 440                 445             


Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser Ser Ile Gly Phe 
    450                 455                 460                 


Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu Leu Cys Asp Pro 
465                 470                 475                 480 


Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu Ser Asn Leu Arg 
                485                 490                 495     


Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr Val Asn Gly Leu 
            500                 505                 510         


Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val Lys Lys Gly Glu 
        515                 520                 525             


Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala Pro Ser Trp Thr 
    530                 535                 540                 


Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln Asn Glu Asn Gly 
545                 550                 555                 560 


Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn Ile Ala Pro Gln 
                565                 570                 575     


Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn Asn Gln Ala Ser 
            580                 585                 590         


Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn Gln Gly Trp Gln 
        595                 600                 605             


Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val Gly Leu Gly Tyr 
    610                 615                 620                 


Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala Glu Gly Phe Lys 
625                 630                 635                 640 


Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His Glu Thr Ala Glu 
                645                 650                 655     


Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro Asp Val Leu Ala 
            660                 665                 670         


Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala Asp Leu Arg Asp 
        675                 680                 685             


Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln Ser Val Ala Pro 
    690                 695                 700                 


Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala Leu Ala Arg Ala 
705                 710                 715                 720 


Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln Gly Gly Pro Ser 
                725                 730                 735     


Asn Gly 
        


<210>  588
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CasB-CasB

<400>  588

Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln 
1               5                   10                  15      


Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp 
            20                  25                  30          


Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly 
        35                  40                  45              


Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys 
    50                  55                  60                  


Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu 
65                  70                  75                  80  


Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg 
                85                  90                  95      


Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala 
            100                 105                 110         


Asp Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu 
        115                 120                 125             


Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu 
    130                 135                 140                 


Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp 
                165                 170                 175     


Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys 
            180                 185                 190         


Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro 
        195                 200                 205             


Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His 
    210                 215                 220                 


Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn 
225                 230                 235                 240 


Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser 
                245                 250                 255     


Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile 
            260                 265                 270         


Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg 
        275                 280                 285             


Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala 
    290                 295                 300                 


Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu 
305                 310                 315                 320 


Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
                325                 330 


<210>  589
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  589

Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10  


<210>  590
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rAPOBEC1

<400>  590

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  591
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  591

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  592
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rAPOBEC1_CasB-CasB

<400>  592

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala 
225                 230                 235                 240 


Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp 
                245                 250                 255     


Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu 
            260                 265                 270         


Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu 
        275                 280                 285             


Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser 
    290                 295                 300                 


Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr 
305                 310                 315                 320 


Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn 
                325                 330                 335     


Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met 
            340                 345                 350         


Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp 
        355                 360                 365             


Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln 
    370                 375                 380                 


Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala Ser Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp Ala Met 
                405                 410                 415     


Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln 
            420                 425                 430         


Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe 
        435                 440                 445             


Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln 
    450                 455                 460                 


Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile 
465                 470                 475                 480 


Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly 
                485                 490                 495     


Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln 
            500                 505                 510         


Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu 
        515                 520                 525             


Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met 
    530                 535                 540                 


Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe 
545                 550                 555                 560 


Val Leu Thr Thr Asn Lys Asn Ala 
                565             


<210>  593
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_rAPOBEC1

<400>  593

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly Met Ser Ser Glu Thr Gly Pro Val Ala Val 
            500                 505                 510         


Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe 
        515                 520                 525             


Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile 
    530                 535                 540                 


Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr 
545                 550                 555                 560 


Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg 
                565                 570                 575     


Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp 
            580                 585                 590         


Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg 
        595                 600                 605             


Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His 
    610                 615                 620                 


Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly 
625                 630                 635                 640 


Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg 
                645                 650                 655     


Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr 
            660                 665                 670         


Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile 
        675                 680                 685             


Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln 
    690                 695                 700                 


Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu 
705                 710                 715                 720 


Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys 
                725                 730     


<210>  594
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_AID

<400>  594

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly Met Asp Ser Leu Leu Met Asn Arg Arg Lys 
            500                 505                 510         


Phe Leu Tyr Gln Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu 
        515                 520                 525             


Thr Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe 
    530                 535                 540                 


Ser Leu Asp Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu 
545                 550                 555                 560 


Leu Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg 
                565                 570                 575     


Cys Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys 
            580                 585                 590         


Ala Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu 
        595                 600                 605             


Arg Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu 
    610                 615                 620                 


Pro Glu Gly Leu Arg Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile 
625                 630                 635                 640 


Met Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn 
                645                 650                 655     


His Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val 
            660                 665                 670         


Arg Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val 
        675                 680                 685             


Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu 
    690                 695                 700 


<210>  595
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_PmCDA1

<400>  595

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly Met Thr Asp Ala Glu Tyr Val Arg Ile His 
            500                 505                 510         


Glu Lys Leu Asp Ile Tyr Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys 
        515                 520                 525             


Lys Ser Val Ser His Arg Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg 
    530                 535                 540                 


Gly Glu Arg Arg Ala Cys Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln 
545                 550                 555                 560 


Ser Gly Thr Glu Arg Gly Ile His Ala Glu Ile Phe Ser Ile Arg Lys 
                565                 570                 575     


Val Glu Glu Tyr Leu Arg Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp 
            580                 585                 590         


Tyr Ser Ser Trp Ser Pro Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu 
        595                 600                 605             


Trp Tyr Asn Gln Glu Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp 
    610                 615                 620                 


Ala Cys Lys Leu Tyr Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu 
625                 630                 635                 640 


Trp Asn Leu Arg Asp Asn Gly Val Gly Leu Asn Val Met Val Ser Glu 
                645                 650                 655     


His Tyr Gln Cys Cys Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln 
            660                 665                 670         


Leu Asn Glu Asn Arg Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys 
        675                 680                 685             


Arg Arg Ser Glu Leu Ser Ile Met Ile Gln Val Lys Ile Leu His Thr 
    690                 695                 700                 


Thr Lys Ser Pro Ala Val 
705                 710 


<210>  596
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_Human APOBEC1

<400>  596

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly Met Thr Ser Glu Lys Gly Pro Ser Thr Gly 
            500                 505                 510         


Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro Trp Glu Phe Asp Val Phe 
        515                 520                 525             


Tyr Asp Pro Arg Glu Leu Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile 
    530                 535                 540                 


Lys Trp Gly Met Ser Arg Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr 
545                 550                 555                 560 


Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg 
                565                 570                 575     


Asp Phe His Pro Ser Met Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp 
            580                 585                 590         


Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg 
        595                 600                 605             


His Pro Gly Val Thr Leu Val Ile Tyr Val Ala Arg Leu Phe Trp His 
    610                 615                 620                 


Met Asp Gln Gln Asn Arg Gln Gly Leu Arg Asp Leu Val Asn Ser Gly 
625                 630                 635                 640 


Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg 
                645                 650                 655     


Asn Phe Val Asn Tyr Pro Pro Gly Asp Glu Ala His Trp Pro Gln Tyr 
            660                 665                 670         


Pro Pro Leu Trp Met Met Leu Tyr Ala Leu Glu Leu His Cys Ile Ile 
        675                 680                 685             


Leu Ser Leu Pro Pro Cys Leu Lys Ile Ser Arg Arg Trp Gln Asn His 
    690                 695                 700                 


Leu Thr Phe Phe Arg Leu His Leu Gln Asn Cys His Tyr Gln Thr Ile 
705                 710                 715                 720 


Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile His Pro Ser Val Ala 
                725                 730                 735     


Trp Arg 
        


<210>  597
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_APOBEC3F

<400>  597

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly Met Lys Pro His Phe Arg Asn Thr Val Glu 
            500                 505                 510         


Arg Met Tyr Arg Asp Thr Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile 
        515                 520                 525             


Leu Ser Arg Arg Asn Thr Val Trp Leu Cys Tyr Glu Val Lys Thr Lys 
    530                 535                 540                 


Gly Pro Ser Arg Pro Arg Leu Asp Ala Lys Ile Phe Arg Gly Gln Val 
545                 550                 555                 560 


Tyr Ser Gln Pro Glu His His Ala Glu Met Cys Phe Leu Ser Trp Phe 
                565                 570                 575     


Cys Gly Asn Gln Leu Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe 
            580                 585                 590         


Val Ser Trp Thr Pro Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe 
        595                 600                 605             


Leu Ala Glu His Pro Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu 
    610                 615                 620                 


Tyr Tyr Tyr Trp Glu Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser 
625                 630                 635                 640 


Gln Ala Gly Ala Arg Val Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr 
                645                 650                 655     


Cys Trp Glu Asn Phe Val Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp 
            660                 665                 670         


Tyr Lys Phe Asp Asp Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu 
        675                 680                 685             


Ile Leu Arg Asn Pro Met Glu Ala Met Tyr Pro His Ile Phe Tyr Phe 
    690                 695                 700                 


His Phe Lys Asn Leu Arg Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu 
705                 710                 715                 720 


Cys Phe Thr Met Glu Val Val Lys His His Ser Pro Val Ser Trp Lys 
                725                 730                 735     


Arg Gly Val Phe Arg Asn Gln Val Asp Pro Glu Thr His Cys His Ala 
            740                 745                 750         


Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn 
        755                 760                 765             


Thr Asn Tyr Glu Val Thr Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu 
    770                 775                 780                 


Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser Asn Val Asn 
785                 790                 795                 800 


Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr 
                805                 810                 815     


Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Ala Ser Val Glu Ile 
            820                 825                 830         


Met Gly Tyr Lys Asp Phe Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn 
        835                 840                 845             


Asp Asp Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu 
    850                 855                 860                 


Phe Leu Asp Ser Lys Leu Gln Glu Ile Leu Glu 
865                 870                 875 


<210>  598
<211>  886
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas8_APOBEC3G

<400>  598

Met Asn Leu Leu Ile Asp Asn Trp Ile Pro Val Arg Pro Arg Asn Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Leu Gln Ser Leu Tyr Cys Ser Arg Asp 
            20                  25                  30          


Gln Trp Arg Leu Ser Leu Pro Arg Asp Asp Met Glu Leu Ala Ala Leu 
        35                  40                  45              


Ala Leu Leu Val Cys Ile Gly Gln Ile Ile Ala Pro Ala Lys Asp Asp 
    50                  55                  60                  


Val Glu Phe Arg His Arg Ile Met Asn Pro Leu Thr Glu Asp Glu Phe 
65                  70                  75                  80  


Gln Gln Leu Ile Ala Pro Trp Ile Asp Met Phe Tyr Leu Asn His Ala 
                85                  90                  95      


Glu His Pro Phe Met Gln Thr Lys Gly Val Lys Ala Asn Asp Val Thr 
            100                 105                 110         


Pro Met Glu Lys Leu Leu Ala Gly Val Ser Gly Ala Thr Asn Cys Ala 
        115                 120                 125             


Phe Val Asn Gln Pro Gly Gln Gly Glu Ala Leu Cys Gly Gly Cys Thr 
    130                 135                 140                 


Ala Ile Ala Leu Phe Asn Gln Ala Asn Gln Ala Pro Gly Phe Gly Gly 
145                 150                 155                 160 


Gly Phe Lys Ser Gly Leu Arg Gly Gly Thr Pro Val Thr Thr Phe Val 
                165                 170                 175     


Arg Gly Ile Asp Leu Arg Ser Thr Val Leu Leu Asn Val Leu Thr Leu 
            180                 185                 190         


Pro Arg Leu Gln Lys Gln Phe Pro Asn Glu Ser His Thr Glu Asn Gln 
        195                 200                 205             


Pro Thr Trp Ile Lys Pro Ile Lys Ser Asn Glu Ser Ile Pro Ala Ser 
    210                 215                 220                 


Ser Ile Gly Phe Val Arg Gly Leu Phe Trp Gln Pro Ala His Ile Glu 
225                 230                 235                 240 


Leu Cys Asp Pro Ile Gly Ile Gly Lys Cys Ser Cys Cys Gly Gln Glu 
                245                 250                 255     


Ser Asn Leu Arg Tyr Thr Gly Phe Leu Lys Glu Lys Phe Thr Phe Thr 
            260                 265                 270         


Val Asn Gly Leu Trp Pro His Pro His Ser Pro Cys Leu Val Thr Val 
        275                 280                 285             


Lys Lys Gly Glu Val Glu Glu Lys Phe Leu Ala Phe Thr Thr Ser Ala 
    290                 295                 300                 


Pro Ser Trp Thr Gln Ile Ser Arg Val Val Val Asp Lys Ile Ile Gln 
305                 310                 315                 320 


Asn Glu Asn Gly Asn Arg Val Ala Ala Val Val Asn Gln Phe Arg Asn 
                325                 330                 335     


Ile Ala Pro Gln Ser Pro Leu Glu Leu Ile Met Gly Gly Tyr Arg Asn 
            340                 345                 350         


Asn Gln Ala Ser Ile Leu Glu Arg Arg His Asp Val Leu Met Phe Asn 
        355                 360                 365             


Gln Gly Trp Gln Gln Tyr Gly Asn Val Ile Asn Glu Ile Val Thr Val 
    370                 375                 380                 


Gly Leu Gly Tyr Lys Thr Ala Leu Arg Lys Ala Leu Tyr Thr Phe Ala 
385                 390                 395                 400 


Glu Gly Phe Lys Asn Lys Asp Phe Lys Gly Ala Gly Val Ser Val His 
                405                 410                 415     


Glu Thr Ala Glu Arg His Phe Tyr Arg Gln Ser Glu Leu Leu Ile Pro 
            420                 425                 430         


Asp Val Leu Ala Asn Val Asn Phe Ser Gln Ala Asp Glu Val Ile Ala 
        435                 440                 445             


Asp Leu Arg Asp Lys Leu His Gln Leu Cys Glu Met Leu Phe Asn Gln 
    450                 455                 460                 


Ser Val Ala Pro Tyr Ala His His Pro Lys Leu Ile Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Arg Ala Thr Leu Tyr Lys His Leu Arg Glu Leu Lys Pro Gln 
                485                 490                 495     


Gly Gly Pro Ser Asn Gly Met Lys Pro His Phe Arg Asn Thr Val Glu 
            500                 505                 510         


Arg Met Tyr Arg Asp Thr Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile 
        515                 520                 525             


Leu Ser Arg Arg Asn Thr Val Trp Leu Cys Tyr Glu Val Lys Thr Lys 
    530                 535                 540                 


Gly Pro Ser Arg Pro Pro Leu Asp Ala Lys Ile Phe Arg Gly Gln Val 
545                 550                 555                 560 


Tyr Ser Glu Leu Lys Tyr His Pro Glu Met Arg Phe Phe His Trp Phe 
                565                 570                 575     


Ser Lys Trp Arg Lys Leu His Arg Asp Gln Glu Tyr Glu Val Thr Trp 
            580                 585                 590         


Tyr Ile Ser Trp Ser Pro Cys Thr Lys Cys Thr Arg Asp Met Ala Thr 
        595                 600                 605             


Phe Leu Ala Glu Asp Pro Lys Val Thr Leu Thr Ile Phe Val Ala Arg 
    610                 615                 620                 


Leu Tyr Tyr Phe Trp Asp Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu 
625                 630                 635                 640 


Cys Gln Lys Arg Asp Gly Pro Arg Ala Thr Met Lys Ile Met Asn Tyr 
                645                 650                 655     


Asp Glu Phe Gln His Cys Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu 
            660                 665                 670         


Leu Phe Glu Pro Trp Asn Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His 
        675                 680                 685             


Ile Met Leu Gly Glu Ile Leu Arg His Ser Met Asp Pro Pro Thr Phe 
    690                 695                 700                 


Thr Phe Asn Phe Asn Asn Glu Pro Trp Val Arg Gly Arg His Glu Thr 
705                 710                 715                 720 


Tyr Leu Cys Tyr Glu Val Glu Arg Met His Asn Asp Thr Trp Val Leu 
                725                 730                 735     


Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn Gln Ala Pro His Lys His 
            740                 745                 750         


Gly Phe Leu Glu Gly Arg His Ala Glu Leu Cys Phe Leu Asp Val Ile 
        755                 760                 765             


Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe 
    770                 775                 780                 


Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu Met Ala Lys Phe 
785                 790                 795                 800 


Ile Ser Lys Asn Lys His Val Ser Leu Cys Ile Phe Thr Ala Arg Ile 
                805                 810                 815     


Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu 
            820                 825                 830         


Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr Ser Glu Phe Lys His Cys 
        835                 840                 845             


Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp 
    850                 855                 860                 


Gly Leu Asp Glu His Ser Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile 
865                 870                 875                 880 


Leu Gln Asn Gln Glu Asn 
                885     


<210>  599
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PvuIIHIFIT46G

<400>  599

Met Ser His Pro Asp Leu Asn Lys Leu Leu Glu Leu Trp Pro His Ile 
1               5                   10                  15      


Gln Glu Tyr Gln Asp Leu Ala Leu Lys His Gly Ile Asn Asp Ile Phe 
            20                  25                  30          


Gln Asp Asn Gly Gly Lys Leu Leu Gln Val Leu Leu Ile Gly Gly Leu 
        35                  40                  45              


Thr Val Leu Pro Gly Arg Glu Gly Asn Asp Ala Val Asp Asn Ala Gly 
    50                  55                  60                  


Gln Glu Tyr Glu Leu Lys Ser Ile Asn Ile Asp Leu Thr Lys Gly Phe 
65                  70                  75                  80  


Ser Thr His His His Met Asn Pro Val Ile Ile Ala Lys Tyr Arg Gln 
                85                  90                  95      


Val Pro Trp Ile Phe Ala Ile Tyr Arg Gly Ile Ala Ile Glu Ala Ile 
            100                 105                 110         


Tyr Arg Leu Glu Pro Lys Asp Leu Glu Phe Tyr Tyr Asp Lys Trp Glu 
        115                 120                 125             


Arg Lys Trp Tyr Ser Asp Gly His Lys Asp Ile Asn Asn Pro Lys Ile 
    130                 135                 140                 


Pro Val Lys Tyr Val Met Glu His Gly Thr Lys Ile Tyr 
145                 150                 155         


<210>  600
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PvuIIsinglechainT46G

<400>  600

Ser His Pro Asp Leu Asn Lys Leu Leu Glu Leu Trp Pro His Ile Gln 
1               5                   10                  15      


Glu Tyr Gln Asp Leu Ala Leu Lys His Gly Ile Asn Asp Ile Phe Gln 
            20                  25                  30          


Asp Asn Gly Gly Lys Leu Leu Gln Val Leu Leu Ile Gly Gly Leu Thr 
        35                  40                  45              


Val Leu Pro Gly Arg Glu Gly Asn Asp Ala Val Asp Asn Ala Gly Gln 
    50                  55                  60                  


Glu Tyr Glu Leu Lys Ser Ile Asn Ile Asp Leu Thr Lys Gly Phe Ser 
65                  70                  75                  80  


Thr His His His Met Asn Pro Val Ile Ile Ala Lys Tyr Arg Gln Val 
                85                  90                  95      


Pro Trp Ile Phe Ala Ile Tyr Arg Gly Ile Ala Ile Glu Ala Ile Tyr 
            100                 105                 110         


Arg Leu Glu Pro Lys Asp Leu Glu Phe Tyr Tyr Asp Lys Trp Glu Arg 
        115                 120                 125             


Lys Trp Tyr Ser Asp Gly His Lys Asp Ile Asn Asn Pro Lys Ile Pro 
    130                 135                 140                 


Val Lys Tyr Val Met Glu His Gly Thr Lys Ile Tyr Gly Ser Gly Gly 
145                 150                 155                 160 


Ser His Pro Asp Leu Asn Lys Leu Leu Glu Leu Trp Pro His Ile Gln 
                165                 170                 175     


Glu Tyr Gln Asp Leu Ala Leu Lys His Gly Ile Asn Asp Ile Phe Gln 
            180                 185                 190         


Asp Asn Gly Gly Lys Leu Leu Gln Val Leu Leu Ile Gly Gly Leu Thr 
        195                 200                 205             


Val Leu Pro Gly Arg Glu Gly Asn Asp Ala Val Asp Asn Ala Gly Gln 
    210                 215                 220                 


Glu Tyr Glu Leu Lys Ser Ile Asn Ile Asp Leu Thr Lys Gly Phe Ser 
225                 230                 235                 240 


Thr His His His Met Asn Pro Val Ile Ile Ala Lys Tyr Arg Gln Val 
                245                 250                 255     


Pro Trp Ile Phe Ala Ile Tyr Arg Gly Ile Ala Ile Glu Ala Ile Tyr 
            260                 265                 270         


Arg Leu Glu Pro Lys Asp Leu Glu Phe Tyr Tyr Asp Lys Trp Glu Arg 
        275                 280                 285             


Lys Trp Tyr Ser Asp Gly His Lys Asp Ile Asn Asn Pro Lys Ile Pro 
    290                 295                 300                 


Val Lys Tyr Val Met Glu His Gly Thr Lys Ile Tyr 
305                 310                 315     


<210>  601
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: I-TevI1-169Q158R

<400>  601

Met Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys Val 
1               5                   10                  15      


Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His Phe 
            20                  25                  30          


Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg Ser 
        35                  40                  45              


Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu Ile 
    50                  55                  60                  


Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile Lys 
65                  70                  75                  80  


Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr Phe 
                85                  90                  95      


Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys Lys 
            100                 105                 110         


Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp Asn 
    130                 135                 140                 


Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Arg Thr Ser 
145                 150                 155                 160 


Ala Tyr Thr Cys Ser Lys Cys Arg Asn 
                165                 


<210>  602
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: I-TevI1-169

<400>  602

Met Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys Val 
1               5                   10                  15      


Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His Phe 
            20                  25                  30          


Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg Ser 
        35                  40                  45              


Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu Ile 
    50                  55                  60                  


Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile Lys 
65                  70                  75                  80  


Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr Phe 
                85                  90                  95      


Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys Lys 
            100                 105                 110         


Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp Asn 
    130                 135                 140                 


Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr Ser 
145                 150                 155                 160 


Ala Tyr Thr Cys Ser Lys Cys Arg Asn 
                165                 


<210>  603
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BcnI singlechain

<400>  603

Met Lys Ile Trp Ser Lys Glu Glu Val Val Asn Lys Leu His Glu Ile 
1               5                   10                  15      


Lys Asn Lys Gly Tyr Leu Ser Val Pro Thr Asp Met Phe Arg Thr Asp 
            20                  25                  30          


Asp Gly Val Val Gly Gln Ile Leu Glu Arg Gln Phe Gly Val Gln Glu 
        35                  40                  45              


Asn Asn Ile Thr Leu Gly Asp Leu Gly Glu Phe Glu Leu Lys Gly Met 
    50                  55                  60                  


Arg Asn Arg Lys Ala Lys Ser Asn Leu Thr Leu Phe His Lys Lys Pro 
65                  70                  75                  80  


Val Ala Gly Gln Thr Val Ile Gln Ile Phe Asn Arg Phe Gly Tyr Val 
                85                  90                  95      


Lys Pro Ser Ser Arg Asn Pro Glu Val Met Lys Lys Lys Leu Phe Thr 
            100                 105                 110         


Thr Ile Lys Gly Gly Arg Leu Asn Asn Leu Gly Leu Thr Leu Asn Ala 
        115                 120                 125             


Lys His Ala Ser Glu Ile Asn Leu Tyr Tyr Gln Asp Glu Tyr Leu Ser 
    130                 135                 140                 


Thr Trp Asp Leu Asn Leu Ser Lys Ile Glu Lys Leu Val Leu Val Phe 
145                 150                 155                 160 


Ala Glu Thr Ile Gly Arg Ala Asn Ser Pro Glu Glu Gln Phe His Phe 
                165                 170                 175     


Thr Lys Ala Tyr Met Leu Thr Glu Ile Asn Asp Ile Thr Ser Leu Ile 
            180                 185                 190         


Asn Asp Gly Val Leu Val Met Asp Leu Cys Ile Asp Gln Asp Leu Ser 
        195                 200                 205             


Lys Ser Lys Gly Pro His Asp Arg Gly Pro His Leu Arg Ile Pro Ile 
    210                 215                 220                 


Ser Lys Leu Asp Lys Leu Tyr Arg Asn Ile Glu Arg Leu Leu 
225                 230                 235             


<210>  604
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MvaI singlechain

<400>  604

Met Lys Ser Met Ser Glu Tyr Leu Asn Leu Leu Lys Glu Ala Ile Gln 
1               5                   10                  15      


Asn Val Val Asp Gly Gly Trp His Glu Thr Lys Arg Lys Gly Asn Thr 
            20                  25                  30          


Gly Ile Gly Lys Thr Phe Glu Asp Leu Leu Glu Lys Glu Glu Asp Asn 
        35                  40                  45              


Leu Asp Ala Pro Asp Phe His Asp Ile Glu Ile Lys Thr His Glu Thr 
    50                  55                  60                  


Ala Ala Lys Ser Leu Leu Thr Leu Phe Thr Lys Ser Pro Thr Asn Pro 
65                  70                  75                  80  


Arg Gly Ala Asn Thr Met Leu Arg Asn Arg Tyr Gly Lys Lys Asp Glu 
                85                  90                  95      


Tyr Gly Asn Asn Ile Leu His Gln Thr Val Ser Gly Asn Arg Lys Thr 
            100                 105                 110         


Asn Ser Asn Ser Tyr Asn Tyr Asp Phe Lys Ile Asp Ile Asp Trp Glu 
        115                 120                 125             


Ser Gln Val Val Arg Leu Glu Val Phe Asp Lys Gln Asp Ile Met Ile 
    130                 135                 140                 


Asp Asn Ser Val Tyr Trp Ser Phe Asp Ser Leu Gln Asn Gln Leu Asp 
145                 150                 155                 160 


Lys Lys Leu Lys Tyr Ile Ala Val Ile Ser Ala Glu Ser Lys Ile Glu 
                165                 170                 175     


Asn Glu Lys Lys Tyr Tyr Lys Tyr Asn Ser Ala Asn Leu Phe Thr Asp 
            180                 185                 190         


Leu Thr Val Gln Ser Leu Cys Arg Gly Ile Glu Asn Gly Asp Ile Lys 
        195                 200                 205             


Val Asp Ile Arg Ile Gly Ala Tyr His Ser Gly Lys Lys Lys Gly Lys 
    210                 215                 220                 


Thr His Asp His Gly Thr Ala Phe Arg Ile Asn Met Glu Lys Leu Leu 
225                 230                 235                 240 


Glu Tyr Gly Glu Val Lys Val Ile Val 
                245                 


<210>  605
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNaseI

<400>  605

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys 
            260 


<210>  606
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3

<400>  606

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  607
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: S1Aspergillus

<400>  607

Trp Gly Asn Leu Gly His Glu Thr Val Ala Tyr Ile Ala Gln Ser Phe 
1               5                   10                  15      


Val Ala Ser Ser Thr Glu Ser Phe Cys Gln Asn Ile Leu Gly Asp Asp 
            20                  25                  30          


Ser Thr Ser Tyr Leu Ala Asn Val Ala Thr Trp Ala Asp Thr Tyr Lys 
        35                  40                  45              


Tyr Thr Asp Ala Gly Glu Phe Ser Lys Pro Tyr His Phe Ile Asp Ala 
    50                  55                  60                  


Gln Asp Asn Pro Pro Gln Ser Cys Gly Val Asp Tyr Asp Arg Asp Cys 
65                  70                  75                  80  


Gly Ser Ala Gly Cys Ser Ile Ser Ala Ile Gln Asn Tyr Thr Asn Ile 
                85                  90                  95      


Leu Leu Glu Ser Pro Asn Gly Ser Glu Ala Leu Asn Ala Leu Lys Phe 
            100                 105                 110         


Val Val His Ile Ile Gly Asp Ile His Gln Pro Leu His Asp Glu Asn 
        115                 120                 125             


Leu Glu Ala Gly Gly Asn Gly Ile Asp Val Thr Tyr Asp Gly Glu Thr 
    130                 135                 140                 


Thr Asn Leu His His Ile Trp Asp Thr Asn Met Pro Glu Glu Ala Ala 
145                 150                 155                 160 


Gly Gly Tyr Ser Leu Ser Val Ala Lys Thr Tyr Ala Asp Leu Leu Thr 
                165                 170                 175     


Glu Arg Ile Lys Thr Gly Thr Tyr Ser Ser Lys Lys Asp Ser Trp Thr 
            180                 185                 190         


Asp Gly Ile Asp Ile Lys Asp Pro Val Ser Thr Ser Met Ile Trp Ala 
        195                 200                 205             


Ala Asp Ala Asn Thr Tyr Val Cys Ser Thr Val Leu Asp Asp Gly Leu 
    210                 215                 220                 


Ala Tyr Ile Asn Ser Thr Asp Leu Ser Gly Glu Tyr Tyr Asp Lys Ser 
225                 230                 235                 240 


Gln Pro Val Phe Glu Glu Leu Ile Ala Lys Ala Gly Tyr Arg Leu Ala 
                245                 250                 255     


Ala Trp Leu Asp Leu Ile Ala Ser Gln Pro Ser 
            260                 265         


<210>  608
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rAPOBEC1

<400>  608

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala 
225                 230                 235                 240 


Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp 
                245                 250                 255     


Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu 
            260                 265                 270         


Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu 
        275                 280                 285             


Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser 
    290                 295                 300                 


Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr 
305                 310                 315                 320 


Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn 
                325                 330                 335     


Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met 
            340                 345                 350         


Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp 
        355                 360                 365             


Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln 
    370                 375                 380                 


Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala Ser Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp Ala Met 
                405                 410                 415     


Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln 
            420                 425                 430         


Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe 
        435                 440                 445             


Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln 
    450                 455                 460                 


Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile 
465                 470                 475                 480 


Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly 
                485                 490                 495     


Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln 
            500                 505                 510         


Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu 
        515                 520                 525             


Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met 
    530                 535                 540                 


Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe 
545                 550                 555                 560 


Val Leu Thr Thr Asn Lys Asn Ala 
                565             


<210>  609
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AID

<400>  609

Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln 
1               5                   10                  15      


Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp 
            20                  25                  30          


Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly 
        35                  40                  45              


Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys 
    50                  55                  60                  


Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu 
65                  70                  75                  80  


Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg 
                85                  90                  95      


Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala 
            100                 105                 110         


Asp Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu 
        115                 120                 125             


Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu 
    130                 135                 140                 


Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp 
                165                 170                 175     


Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys 
            180                 185                 190         


Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro 
        195                 200                 205             


Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His 
    210                 215                 220                 


Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn 
225                 230                 235                 240 


Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser 
                245                 250                 255     


Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile 
            260                 265                 270         


Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg 
        275                 280                 285             


Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala 
    290                 295                 300                 


Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu 
305                 310                 315                 320 


Asp Phe Val Leu Thr Thr Asn Lys Asn Ala Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr 
            340                 345                 350         


Gln Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu 
        355                 360                 365             


Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp 
    370                 375                 380                 


Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe 
385                 390                 395                 400 


Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg 
                405                 410                 415     


Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His 
            420                 425                 430         


Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe 
        435                 440                 445             


Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly 
    450                 455                 460                 


Leu Arg Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe 
465                 470                 475                 480 


Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg 
                485                 490                 495     


Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser 
            500                 505                 510         


Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu 
        515                 520                 525             


Arg Asp Ala Phe Arg Thr Leu Gly Leu 
    530                 535         


<210>  610
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CPmCDA1

<400>  610

Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln 
1               5                   10                  15      


Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp 
            20                  25                  30          


Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly 
        35                  40                  45              


Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys 
    50                  55                  60                  


Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu 
65                  70                  75                  80  


Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg 
                85                  90                  95      


Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala 
            100                 105                 110         


Asp Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu 
        115                 120                 125             


Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu 
    130                 135                 140                 


Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp 
                165                 170                 175     


Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys 
            180                 185                 190         


Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro 
        195                 200                 205             


Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His 
    210                 215                 220                 


Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn 
225                 230                 235                 240 


Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser 
                245                 250                 255     


Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile 
            260                 265                 270         


Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg 
        275                 280                 285             


Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala 
    290                 295                 300                 


Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu 
305                 310                 315                 320 


Asp Phe Val Leu Thr Thr Asn Lys Asn Ala Gly Gly Ser Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu 
            340                 345                 350         


Asp Ile Tyr Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val 
        355                 360                 365             


Ser His Arg Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg 
    370                 375                 380                 


Arg Ala Cys Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr 
385                 390                 395                 400 


Glu Arg Gly Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu 
                405                 410                 415     


Tyr Leu Arg Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser 
            420                 425                 430         


Trp Ser Pro Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn 
        435                 440                 445             


Gln Glu Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys 
    450                 455                 460                 


Leu Tyr Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu 
465                 470                 475                 480 


Arg Asp Asn Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln 
                485                 490                 495     


Cys Cys Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu 
            500                 505                 510         


Asn Arg Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser 
        515                 520                 525             


Glu Leu Ser Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser 
    530                 535                 540                 


Pro Ala Val 
545         


<210>  611
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human APOBEC1

<400>  611

Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                245                 250                 255     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            260                 265                 270         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        275                 280                 285             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    290                 295                 300                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
305                 310                 315                 320 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                325                 330                 335     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            340                 345                 350         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        355                 360                 365             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    370                 375                 380                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
385                 390                 395                 400 


Thr Asn Lys Asn Ala Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Met 
                405                 410                 415     


Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu 
            420                 425                 430         


Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu 
        435                 440                 445             


Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp 
    450                 455                 460                 


Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu 
465                 470                 475                 480 


Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln 
                485                 490                 495     


Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile 
            500                 505                 510         


Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp 
        515                 520                 525             


Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp 
    530                 535                 540                 


Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg 
545                 550                 555                 560 


Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala 
                565                 570                 575 


<210>  612
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human APOBEC3F

<400>  612

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala 
    370                 375                 380                 


Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp 
385                 390                 395                 400 


Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu 
                405                 410                 415     


Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu 
            420                 425                 430         


Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser 
        435                 440                 445             


Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr 
    450                 455                 460                 


Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met 
                485                 490                 495     


Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp 
            500                 505                 510         


Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln 
        515                 520                 525             


Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala Ser Gly 
    530                 535                 540                 


Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp Ala Met 
545                 550                 555                 560 


Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln 
                565                 570                 575     


Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe 
            580                 585                 590         


Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln 
        595                 600                 605             


Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile 
    610                 615                 620                 


Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly 
625                 630                 635                 640 


Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln 
                645                 650                 655     


Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu 
            660                 665                 670         


Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met 
        675                 680                 685             


Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe 
    690                 695                 700                 


Val Leu Thr Thr Asn Lys Asn Ala 
705                 710         


<210>  613
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: APOBEC3G

<400>  613

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ala Asp Glu Ile Asp Ala 
385                 390                 395                 400 


Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala 
                405                 410                 415     


Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala 
            420                 425                 430         


Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln 
        435                 440                 445             


Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val 
    450                 455                 460                 


Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu 
465                 470                 475                 480 


Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe 
                485                 490                 495     


Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg 
            500                 505                 510         


Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg 
        515                 520                 525             


Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp 
    530                 535                 540                 


Phe Val Leu Thr Thr Asn Lys Asn Ala Ser Gly Gly Ser Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Ser Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr Arg Ala 
                565                 570                 575     


Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg Val Ser 
            580                 585                 590         


Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu Val Gln 
        595                 600                 605             


Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu Arg Met 
    610                 615                 620                 


Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln Asp Lys 
625                 630                 635                 640 


Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu Ala Asn 
                645                 650                 655     


Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg Ala Asp 
            660                 665                 670         


Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His Ala Glu 
        675                 680                 685             


Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp Trp Gly 
    690                 695                 700                 


Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr Thr Asn 
705                 710                 715                 720 


Lys Asn Ala 
            


<210>  614
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VP16

<400>  614

Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
1               5                   10      


<210>  615
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VP64

<400>  615

Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
1               5                   10                  15      


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            20                  25                  30          


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        35                  40                  45              


Met Leu 
    50  


<210>  616
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: cpCas7 V2

<400>  616

Met Asp Pro Ile Thr Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln 
1               5                   10                  15      


Leu Lys Ser Trp Val Arg Asn Asn Gly Glu Ala Gly Ser Met Ser Asn 
            20                  25                  30          


Phe Ile Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn 
        35                  40                  45              


Arg Asp Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg 
    50                  55                  60                  


Arg Val Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser 
65                  70                  75                  80  


Gly Tyr Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His 
                85                  90                  95      


Leu Ala Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe 
            100                 105                 110         


Asp Gln Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser 
        115                 120                 125             


Val Asp Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val 
    130                 135                 140                 


Val Gly Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Asn Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile 
                165                 170                 175     


Ala Ala Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser 
            180                 185                 190         


Gly Arg Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp 
        195                 200                 205             


Gly Ala Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser 
    210                 215                 220                 


Asp Ile Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser 
225                 230                 235                 240 


Ala His Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr 
                245                 250                 255     


Ala Asn Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser 
            260                 265                 270         


Arg Glu Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala 
        275                 280                 285             


Thr Glu Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro 
    290                 295                 300                 


Ala Asp Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala 
305                 310                 315                 320 


Asn Ala Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro 
                325                 330                 335     


Ser Ile Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr 
            340                 345                 350         


Gly Leu Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val 
        355                 360                 365     


<210>  617
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: tracrRNA (RNA)

<400>  617
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuaagu ucacugccgu auaggcagcu uu                                     92


<210>  618
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: tracrRNA (DNA)

<400>  618
agcatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg       60

gtgcttaagt tcactgccgt ataggcagct tt                                     92


<210>  619
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CXCR4 targeting spacer (RNA)

<400>  619
gaaccagcgg uuaccaugga guuuuagagc uaugcu                                 36


<210>  620
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CXCR4 targeting spacer (DNA)

<400>  620
gaaccagcgg ttaccatgga gttttagagc tatgct                                 36


<210>  621
<211>  918
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(918)
<223>  Cas1

<400>  621
atgacctggc ttccccttaa tcccattcca ctcaaagatc gcgtctccat gatctttctg       60

caatatgggc agatcgatgt aatagatggc gcgtttgtac ttatcgacaa gacagggatc      120

cgcactcata ttcctgttgg ctcggttgcc tgcatcatgc tggaacctgg tacacgggtt      180

tcgcatgcag ctgtacgcct ggctgcgcaa gttggaacat tgttggtatg ggtgggggaa      240

gcgggcgttc gtgtttatgc ttctggtcag cctggaggtg cgcgttcaga taagctgctc      300

tatcaggcaa aacttgctct ggatgaagat ttgcgtctga aggtcgtacg taaaatgttt      360

gaacttcggt ttggagaacc tgcgcctgcc cggcgctccg tagagcaact cagaggtata      420

gaaggcagtc gcgtgcgggc aacctacgca cttctggcga agcaatacgg cgtgacatgg      480

aatggacgtc gctacgatcc gaaagactgg gaaaagggcg atacgatcaa ccaatgcatt      540

agcgctgcaa cttcctgttt atacggcgta actgaagcgg cgatacttgc agctggttat      600

gcaccagcta ttgggtttgt gcatacagga aagcctcttt cctttgttta cgatattgca      660

gacatcatta aatttgacac tgttgtaccg aaagcttttg agatagcgcg tcgtaaccct      720

ggtgagccgg accgggaagt ccgtttggcg tgcagggata tttttcgcag tagtaaaaca      780

ttagccaaat tgattccgct tatagaggac gtgcttgccg ctggagaaat acaaccgccg      840

gccccacctg aagatgcaca gcctgttgcc attccgcttc ctgtttcact gggagatgca      900

ggccatcgga gtagctga                                                    918


<210>  622
<211>  1092
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(1092)
<223>  Cas7

<400>  622
atgtctaact ttatcaatat tcatgttctg atctctcaca gcccttcatg tctgaaccgc       60

gacgatatga acatgcagaa agacgctatt ttcggcggca aaagacgagt aagaatttca      120

agtcaaagcc ttaaacgtgc gatgcgtaaa agtggttatt acgcacaaaa tattggtgaa      180

tccagtctca gaaccattca tcttgcacaa ttacgtgatg ttcttcggca aaaacttggt      240

gaacgttttg accaaaaaat catcgataag acattagcgc tgctctccgg taaatcagtt      300

gatgaagccg aaaagatttc tgccgatgcg gttactccct gggttgtggg agaaatagcc      360

tggttctgtg agcaggttgc aaaagcagag gctgataatc tggatgataa aaagctgctc      420

aaagttctta aggaagatat tgccgccata cgtgtgaatt tacagcaggg tgttgatatt      480

gcgcttagtg gaagaatggc aaccagcggc atgatgactg agttgggaaa agttgatggt      540

gcaatgtcca ttgcgcatgc gatcactact catcaggttg attctgatat tgactggttc      600

accgctgtag atgatttaca ggaacaaggt tctgcacatc tgggaactca ggaattttca      660

tcgggtgttt tttatcgtta tgccaacatt aacctcgctc aacttcagga aaatttaggt      720

ggtgcctcca gggagcaggc tctggaaatt gcaacccatg ttgttcatat gctggcaaca      780

gaggtccctg gagcaaaaca gcgtacttat gccgctttta accctgcgga tatggtaatg      840

gttaatttct ccgatatgcc actttctatg gcaaatgctt ttgaaaaagc ggttaaagcg      900

aaagatggct ttttgcaacc gtctatacag gcgtttaatc aatattggga tcgcgttgcc      960

aatggatatg gtctgaacgg agctgctgcg caattcagct tatctgatgt agacccaatt     1020

actgctcaag ttaaacaaat gcctacttta gaacagttaa aatcctgggt tcgtaataat     1080

ggcgaggcgt ga                                                         1092


<210>  623
<211>  675
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(675)
<223>  Cas5

<400>  623
atgcgtagct atctgattct gcgtctggca ggtccgatgc aggcatgggg tcagccgaca       60

tttgaaggta cacgtccgac aggtcgtttt ccgacacgta gtggtctgct gggtctgctg      120

ggtgcatgtc tgggtattca gcgtgatgat accagcagtc tgcaggcact gagcgaaagc      180

gtgcagtttg cagttcgttg tgatgaactg attctggatg atcgtcgtgt tagcgtgacc      240

ggtctgcgtg attatcatac cgttctgggt gcacgtgaag attatcgtgg tctgaaaagc      300

catgaaacca ttcagacctg gcgtgaatat ctgtgtgatg caagttttac cgttgcactg      360

tggctgaccc cgcatgcaac aatggttatt agcgaactgg aaaaagcagt tctgaaaccg      420

cgttataccc cgtatctggg tcgtcgtagc tgtccgctga cccatccgct gtttctgggt      480

acatgtcagg caagcgatcc gcagaaagca ctgctgaatt atgaaccggt tggtggtgat      540

atttatagcg aagaaagcgt taccggtcat catctgaaat ttaccgcacg tgatgaaccg      600

atgattaccc tgccgcgtca gtttgcaagc cgtgaatggt atgttattaa aggtggtatg      660

gatgttagcc agtaa                                                       675


<210>  624
<211>  2667
<212>  DNA
<213>  Escherichia coli K-12 MG1655


<220>
<221>  misc_feature
<222>  (1)..(2667)
<223>  Cas3

<400>  624
atggaacctt ttaaatatat atgccattac tggggaaaat cctcaaaaag cttgacgaaa       60

ggaaatgata ttcatctgtt aatttatcat tgccttgatg ttgctgctgt tgcagattgc      120

tggtgggatc aatcagtcgt actgcaaaat actttttgcc gaaatgaaat gctatcaaaa      180

cagagggtga aggcctggct gttatttttc attgctcttc atgatattgg aaagtttgat      240

atacgattcc aatataaatc agcagaaagt tggctgaaat taaatcctgc aacgccatca      300

cttaatggtc catcaacaca aatgtgccgt aaatttaatc atggtgcagc cggtctgtat      360

tggtttaacc aggattcact ttcagagcaa tctctcgggg attttttcag tttttttgat      420

gccgctcctc atccttatga gtcctggttt ccatgggtag aggccgttac aggacatcat      480

ggttttatct tacattccca ggatcaagat aagtcgcgtt gggaaatgcc agcttctctg      540

gcatcttatg ctgcgcaaga taaacaggct cgtgaggagt ggatatctgt actggaagca      600

ttatttttaa cgccagcggg gttatctata aacgatatac cacctgattg ttcatcactg      660

ttagcaggtt tttgctcgct tgctgactgg ttaggctcct ggactacaac gaataccttt      720

ctgtttaatg aggatgcgcc ttccgacata aatgctctga gaacgtattt ccaggaccga      780

cagcaggatg cgagccgggt attggagttg agtggacttg tatcaaataa gcgatgttat      840

gaaggtgttc atgcactact ggacaatggc tatcaaccca gacaattaca ggtgttagtt      900

gatgctcttc cagtagctcc cgggctgacg gtaatagagg cacctacagg ctccggtaaa      960

acggaaacag cgctggccta tgcttggaaa cttattgatc aacaaattgc ggatagtgtt     1020

atttttgccc tcccaacaca agctaccgcg aatgctatgc ttacgagaat ggaagcgagc     1080

gcgagccact tattttcatc cccaaatctt attcttgctc atggcaattc acggtttaac     1140

cacctctttc aatcaataaa atcacgcgcg attactgaac aggggcaaga agaagcgtgg     1200

gttcagtgtt gtcagtggtt gtcacaaagc aataagaaag tgtttcttgg gcaaatcggc     1260

gtttgcacga ttgatcaggt gttgatatcg gtattgccag ttaaacaccg ctttatccgt     1320

ggtttgggaa ttggtcgaag tgttttaatt gttgatgaag ttcatgctta cgacacctat     1380

atgaacggct tgctggaggc agtgctcaag gctcaggctg atgtgggagg gagtgttatt     1440

cttctttccg caaccctacc aatgaaacaa aaacagaaac ttctggatac ttatggtctg     1500

catacagatc cagtggaaaa taactccgca tatccactca ttaactggcg aggtgtgaat     1560

ggtgcgcaac gttttgatct gctagctcat ccagaacaac tcccgccccg cttttcgatt     1620

cagccagaac ctatttattt agctgacatg ttacctgacc ttacgatgtt agagcgaatg     1680

atcgcagcgg caaacgcggg tgcacaggtc tgtcttattt gcaatttggt tgacgttgca     1740

caagtatgct accaacggct aaaggagcta aataacacgc aagtagatat agatttgttt     1800

catgcgcgct ttacgctgaa cgatcgtcgt gaaaaagaga atcgagttat tagcaatttc     1860

ggcaaaaatg ggaagcgaaa tgttggacgg atacttgtcg caacccaggt cgtggaacaa     1920

tcactcgacg ttgattttga ttggttaatt actcagcatt gtcctgcaga tttgcttttc     1980

caacgattgg gccgtttaca tcgccatcat cgcaaatatc gtcccgctgg ttttgagatt     2040

cctgttgcca ccattttgct gcctgatggc gagggttacg gacgacatga gcatatttat     2100

agcaacgtta gagtcatgtg gcggacgcag caacatattg aggagcttaa tggagcatcc     2160

ttatttttcc ctgatgctta ccggcaatgg ctggatagca tttacgatga tgcggaaatg     2220

gatgagccag aatgggtcgg caatggcatg gataaatttg aaagcgccga gtgtgaaaaa     2280

aggttcaagg ctcgcaaggt cctgcagtgg gctgaagaat atagcttgca ggataacgat     2340

gaaaccattc ttgcggtaac gagggatggg gaaatgagcc tgccattatt gccttatgta     2400

caaacgtctt caggtaaaca actgctcgat ggccaggtct acgaggacct aagtcatgaa     2460

cagcagtatg aggcgcttgc acttaatcgc gtcaatgtac ccttcacctg gaaacgtagt     2520

ttttctgaag tagtagatga agatgggtta ctttggctgg aagggaaaca gaatctggat     2580

ggatgggtct ggcagggtaa cagtattgtt attacctata caggggatga agggatgacc     2640

agagtcatcc ctgcaaatcc caaataa                                         2667


<210>  625
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa129F

<400>  625
accggcagca ggaagcgtgg atgctggcct ccctgtgagt tccccgcgcc agcggggata       60

aaccgcaaag tcaaggagca tggaatcccg gcccctc                                97


<210>  626
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa130F

<400>  626
accggtgctt gacatcatta tgagctgagc attgctgagt tccccgcgcc agcggggata       60

aaccggcttc ctgtgtctaa tgaccctgac aacccat                                97


<210>  627
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa131F

<400>  627
accggtaggc cttgggtggc cgatggcctc acagtggagt tccccgcgcc agcggggata       60

aaccggagaa gaagttcagt tcagtgacag gtgagcc                                97


<210>  628
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa132F

<400>  628
accgacttgt ctgtgttgca cagctaggtg aggcccgagt tccccgcgcc agcggggata       60

aaccggcatc accttaccat cagagcagtg cagtgct                                97


<210>  629
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa133F

<400>  629
accggagggc tgagagaggg acaagtcgga accattgagt tccccgcgcc agcggggata       60

aaccggggat gcttccgcct ttccggggct gctggcc                                97


<210>  630
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa134F

<400>  630
accgagctga gcattgctga gctcggaaat cacctggagt tccccgcgcc agcggggata       60

aaccggccag ttttatgaat ggcttcctgt gtctaat                                97


<210>  631
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa135F

<400>  631
accgtctact tccataggga attgcaacca cagtatgagt tccccgcgcc agcggggata       60

aaccggtcct gatcacttat gtaagtaact ccattgt                                97


<210>  632
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa136F

<400>  632
accgtgacat gcccctggat gtcctcctcc acacaggagt tccccgcgcc agcggggata       60

aaccgcatgt acacccctaa gatgcccatc gcgcagc                                97


<210>  633
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa137F

<400>  633
accggccatg gaagacatgc aggatcttgg tgaggtgagt tccccgcgcc agcggggata       60

aaccgatgag tggcgacctg ctggagctgg tgagcca                                97


<210>  634
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa138F

<400>  634
accgaaggcc atggaagaca tgcaggatct tggtgagagt tccccgcgcc agcggggata       60

aaccgagtgg cgacctgctg gagctggtga gccaccc                                97


<210>  635
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa139F

<400>  635
accgagggcc atcagcacct ttcacactca ccccccgagt tccccgcgcc agcggggata       60

aaccgcccct gggggctccc tgattaatgg aggctta                                97


<210>  636
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa140F

<400>  636
accgctgaac agaaggtctc aggaagctcc aggaaggagt tccccgcgcc agcggggata       60

aaccgcatgc aagaaagatg actgtcccag cgagtgg                                97


<210>  637
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa141F

<400>  637
accgtggatc agtctctgcc tcaactcggc cagggtgagt tccccgcgcc agcggggata       60

aaccgaggcc tggttccctg aggaccagcg ggtactg                                97


<210>  638
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa142F

<400>  638
accgcctggc acggaacaag agctcaataa aagtcagagt tccccgcgcc agcggggata       60

aaccggaggc aggattcttc ccatggatag gggaggg                                97


<210>  639
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa143F

<400>  639
accgtgacat gcccctggat gtcctcctcc acacaggagt tccccgcgcc agcggggata       60

aaccgtacac ccctaagatg cccatcgcgc agccctg                                97


<210>  640
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa144F

<400>  640
accgtttctc tgagaattca gtgcatgcac atacaagagt tccccgcgcc agcggggata       60

aaccggttca aacaagctca agagctagaa gaaggag                                97


<210>  641
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa145F

<400>  641
accggagggc tgagagaggg acaagtcgga accattgagt tccccgcgcc agcggggata       60

aaccgcttcc gcctttccgg ggctgctggc ctggccc                                97


<210>  642
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa146F

<400>  642
accgtgtacc ctgccgggta gtggagcggg ttggctgagt tccccgcgcc agcggggata       60

aaccgaaacc tggaaccaga gggggcgtgc ctgccaa                                97


<210>  643
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa147F

<400>  643
accgattctg tatagcaacg cgtaccatct aagaccgagt tccccgcgcc agcggggata       60

aaccgccaag taagtgctga tttgttctca ttcaact                                97


<210>  644
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa148F

<400>  644
accgctgaac agaaggtctc aggaagctcc aggaaggagt tccccgcgcc agcggggata       60

aaccgcaaga aagatgactg tcccagcgag tggcttc                                97


<210>  645
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa149F

<400>  645
accggaagac atgcaggatc ttggtgaggt atccccgagt tccccgcgcc agcggggata       60

aaccgatgag tggcgacctg ctggagctgg tgagcca                                97


<210>  646
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa150F

<400>  646
accggcagca ggaagcgtgg atgctggcct ccctgtgagt tccccgcgcc agcggggata       60

aaccggagca tggaatcccg gcccctcagg agcaggt                                97


<210>  647
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa151F

<400>  647
accgaactgg actgtactgt cagcggagcc cgagttgagt tccccgcgcc agcggggata       60

aaccggaggg agacggattt ctttccttgc tcagcaa                                97


<210>  648
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa152F

<400>  648
accggcaact tggcctcgac tggaagtttc tctgaggagt tccccgcgcc agcggggata       60

aaccgaagga gctgctgtgt cagaggagcc ctcgtaa                                97


<210>  649
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa153F

<400>  649
accggctagc accagctcct cgtagtcgcc gtcctcgagt tccccgcgcc agcggggata       60

aaccgcaccc gagcacggaa ccacagccac cttccac                                97


<210>  650
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa154F

<400>  650
accgctggca cccttggcca cgccggcatc ccggccgagt tccccgcgcc agcggggata       60

aaccgggaag ggcacggtta gcggcaccct cataggt                                97


<210>  651
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa155F

<400>  651
accggggctg tcactggagc tcctgggagg cctgcggagt tccccgcgcc agcggggata       60

aaccgggctg gggctgagct ttaaaatggt tccgact                                97


<210>  652
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa156F

<400>  652
accgggtggg gggtaagctg aatggaatct ctctcggagt tccccgcgcc agcggggata       60

aaccgtgaga ggggctgatg gaagctgata ggcagga                                97


<210>  653
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa157F

<400>  653
accgacatgc aggatcttgg tgaggtatcc ccggcggagt tccccgcgcc agcggggata       60

aaccgatgag tggcgacctg ctggagctgg tgagcca                                97


<210>  654
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa158F

<400>  654
accgtttgtc cctgcagccc ctaccgcccc ctccccgagt tccccgcgcc agcggggata       60

aaccggccct catctccagc taactgtgga gaagccc                                97


<210>  655
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa159F

<400>  655
accgagctga gcattgctga gctcggaaat cacctggagt tccccgcgcc agcggggata       60

aaccgaatgg cttcctgtgt ctaatgaccc tgacaac                                97


<210>  656
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa160F

<400>  656
accgactgtt tcattcatct ctctggaaag caggtggagt tccccgcgcc agcggggata       60

aaccgcccag cacggtgcaa gcttgtaacc gctttaa                                97


<210>  657
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa161F

<400>  657
accgcgtgga tgctggcctc cctgtggccc acgcacgagt tccccgcgcc agcggggata       60

aaccgtcaag gagcatggaa tcccggcccc tcaggag                                97


<210>  658
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa162F

<400>  658
accgctgaac agaaggtctc aggaagctcc aggaaggagt tccccgcgcc agcggggata       60

aaccgatgac tgtcccagcg agtggcttct ctcagac                                97


<210>  659
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa163F

<400>  659
accggcagct gaattcccct tgagacccac cgctaagagt tccccgcgcc agcggggata       60

aaccggcatc tttagtgatc caaggtaaga aaccctg                                97


<210>  660
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa164F

<400>  660
accgggtgtg tgtggagtgg ggagggggaa ataaatgagt tccccgcgcc agcggggata       60

aaccggacgt ccgcgtgttt tctctttcag ttagctg                                97


<210>  661
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa165F

<400>  661
accgagctga gcattgctga gctcggaaat cacctggagt tccccgcgcc agcggggata       60

aaccggcttc ctgtgtctaa tgaccctgac aacccat                                97


<210>  662
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa166F

<400>  662
accgtgacat gcccctggat gtcctcctcc acacaggagt tccccgcgcc agcggggata       60

aaccgatgcc catcgcgcag ccctgcaaca tttttga                                97


<210>  663
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa167F

<400>  663
accgaagagg ttgctacaac ctgacagcct gacagagagt tccccgcgcc agcggggata       60

aaccgggttt atgcgtgtcc acagtacacc ctccctc                                97


<210>  664
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa168F

<400>  664
accggtagcc cggggtgagt ggcatttcat gagggggagt tccccgcgcc agcggggata       60

aaccgtaaaa tttgagagga agacaatatt aatctgt                                97


<210>  665
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa169F

<400>  665
accgttcagg agcagggcgc gtgaaggggc gcgcgggagt tccccgcgcc agcggggata       60

aaccggcgcc gccggcgtgg accgcgcacg gcctcta                                97


<210>  666
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa170F

<400>  666
accgctggtg tctaggagat acacctccac caggctgagt tccccgcgcc agcggggata       60

aaccggtcac cgacttcgag aatgtgcccg aggagga                                97


<210>  667
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa171F

<400>  667
accgactgtc acacttgctg gcctgctcga cgaacagagt tccccgcgcc agcggggata       60

aaccgccggc gtggccaagg gtgccagcat gcgcagc                                97


<210>  668
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa172F

<400>  668
accggctccc cgcaggccac ctttgggtgt tgctaggagt tccccgcgcc agcggggata       60

aaccgcactg tctcagccaa cccgctccac tacccgg                                97


<210>  669
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa173F

<400>  669
accgcaggat cttggtgagg tatccccggc gggcaggagt tccccgcgcc agcggggata       60

aaccgagtgg cgacctgctg gagctggtga gccaccc                                97


<210>  670
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa174F

<400>  670
accgctcagc cccagccctt gaccctcccc agacacgagt tccccgcgcc agcggggata       60

aaccggcctg gcacgagggg atggggatgc ttccgcc                                97


<210>  671
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa175F

<400>  671
accgagctca ataaaagtca ttctgcccac ggacatgagt tccccgcgcc agcggggata       60

aaccggaggc aggattcttc ccatggatag gggaggg                                97


<210>  672
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa176F

<400>  672
accgccattc ataaaactgg ccatggtgct tgacatgagt tccccgcgcc agcggggata       60

aaccgtgcca agccaaagga acaaccctgg ttgttga                                97


<210>  673
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa177F

<400>  673
accgctggcc tccctgtggc ccacgcactg gttggggagt tccccgcgcc agcggggata       60

aaccgtcaag gagcatggaa tcccggcccc tcaggag                                97


<210>  674
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa178F

<400>  674
accgctgcta agtgctcctc tgcctgctgt cacatcgagt tccccgcgcc agcggggata       60

aaccggaatg ctgccgtcgg gcaactcctg gcacact                                97


<210>  675
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa179F

<400>  675
accgatctgt aaggaatcat ctggctgtag aagaatgagt tccccgcgcc agcggggata       60

aaccgccacc aatgccttgg gatacgactc tgtctcc                                97


<210>  676
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa180F

<400>  676
accgcagcct ggaagcccct gctcaccctg ccccacgagt tccccgcgcc agcggggata       60

aaccgctcag agccctgctg cccacaacag agcactg                                97


<210>  677
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa181F

<400>  677
accgcctggc acggaacaag agctcaataa aagtcagagt tccccgcgcc agcggggata       60

aaccggatag gggagggggc ggtaggggct gcaggga                                97


<210>  678
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa182F

<400>  678
accggaaagt tcctgtggag ctgagactgt tttcacgagt tccccgcgcc agcggggata       60

aaccgagata ctgagaatgg ctggaccact cacagca                                97


<210>  679
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa183F

<400>  679
accgctccag gaagctgcca tcagccatgc gctgctgagt tccccgcgcc agcggggata       60

aaccgcatgc aagaaagatg actgtcccag cgagtgg                                97


<210>  680
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa184F

<400>  680
accgaggtgc tggccgtcct tctcccaggt gatgaggagt tccccgcgcc agcggggata       60

aaccgatcca ccgcctcaag ccctcggatg caggcgt                                97


<210>  681
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa185F

<400>  681
accgcgtgga tgctggcctc cctgtggccc acgcacgagt tccccgcgcc agcggggata       60

aaccggaatc ccggcccctc aggagcaggt gaagagg                                97


<210>  682
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa186F

<400>  682
accgagggcc atcagcacct ttcacactca ccccccgagt tccccgcgcc agcggggata       60

aaccggaggc ttagctttct ggatggcatc tagccag                                97


<210>  683
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa187F

<400>  683
accgtgctcc tctgcctgct gtcacatcca gtactggagt tccccgcgcc agcggggata       60

aaccgcatgg aatgctgccg tcgggcaact cctggca                                97


<210>  684
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa188F

<400>  684
accgcccctg gatgtcctcc tccacacagg aaactggagt tccccgcgcc agcggggata       60

aaccgcccat cgcgcagccc tgcaacattt ttgactg                                97


<210>  685
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa189F

<400>  685
accgctctgg gcaaagacag aggagtcctc ctcgatgagt tccccgcgcc agcggggata       60

aaccgaatac cagccccccg gtaagacccc catctgt                                97


<210>  686
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa190F

<400>  686
accgaggagc ccagccgggt gaagtaagaa gaggctgagt tccccgcgcc agcggggata       60

aaccgctcgg tgagtgatgg cagaacgatg cctgcag                                97


<210>  687
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa191F

<400>  687
accgcccccc ccacacgagg aggagcacgc ggtccagagt tccccgcgcc agcggggata       60

aaccgtcact tcagtggaag agtggaaatg catgtac                                97


<210>  688
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa192F

<400>  688
accgactgtt tcattcatct ctctggaaag caggtggagt tccccgcgcc agcggggata       60

aaccgcttgt aaccgcttta attgcccccc agcctgg                                97


<210>  689
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa193F

<400>  689
accggaatct ctctcggagc aggcagccag ccaatcgagt tccccgcgcc agcggggata       60

aaccgtgaga ggggctgatg gaagctgata ggcagga                                97


<210>  690
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa194F

<400>  690
accgtgctcc tctgcctgct gtcacatcca gtactggagt tccccgcgcc agcggggata       60

aaccggaatg ctgccgtcgg gcaactcctg gcacact                                97


<210>  691
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa195F

<400>  691
accgtttctc tgagaattca gtgcatgcac atacaagagt tccccgcgcc agcggggata       60

aaccgaagga gctgctgtgt cagaggagcc ctcgtaa                                97


<210>  692
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa196F

<400>  692
accgaatcct ggagcgacag aaaagaaata tagaccgagt tccccgcgcc agcggggata       60

aaccgtgggt ttctacactt gcaatgccac caatgcc                                97


<210>  693
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa197F

<400>  693
accgactgtc acacttgctg gcctgctcga cgaacagagt tccccgcgcc agcggggata       60

aaccgggtgc cagcatgcgc agcctgcgcg tgctcaa                                97


<210>  694
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa198F

<400>  694
accgcctgca ggcatcgttc tgccatcact caccgagagt tccccgcgcc agcggggata       60

aaccgcttct aaggcatggt cgggggagag ggccaac                                97


<210>  695
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa199F

<400>  695
accgcaaaac aggtctagaa aagttggctg taaaaagagt tccccgcgcc agcggggata       60

aaccggtgac tttttaaaat aaaaacaaac aaacgtt                                97


<210>  696
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa200F

<400>  696
accgctccag gaagctgcca tcagccatgc gctgctgagt tccccgcgcc agcggggata       60

aaccgaaaga tgactgtccc agcgagtggc ttctctc                                97


<210>  697
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa201F

<400>  697
accgctggcc tccctgtggc ccacgcactg gttggggagt tccccgcgcc agcggggata       60

aaccggaatc ccggcccctc aggagcaggt gaagagg                                97


<210>  698
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa202F

<400>  698
accgtcactg tgcactggaa agagattgca agagaggagt tccccgcgcc agcggggata       60

aaccgcacac aggaggctgt agcccaaaaa caaagcc                                97


<210>  699
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa203F

<400>  699
accgacgtct ctggtctgta ggccgacccc acatgtgagt tccccgcgcc agcggggata       60

aaccgagctg tgtcgccagc ccaagcccag cacggtg                                97


<210>  700
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa204F

<400>  700
accgctgcca tcagccatgc gctgcttgca aagaacgagt tccccgcgcc agcggggata       60

aaccgcatgc aagaaagatg actgtcccag cgagtgg                                97


<210>  701
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa205F

<400>  701
accgaggctt ggcttcagag ccagcccaat ctgcgtgagt tccccgcgcc agcggggata       60

aaccggggaa cacagaccag gaagctcggt gagtgat                                97


<210>  702
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa206F

<400>  702
accgtcctcc tccacacagg aaactgcccg gctctggagt tccccgcgcc agcggggata       60

aaccgcccat cgcgcagccc tgcaacattt ttgactg                                97


<210>  703
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa207F

<400>  703
accgctccag gaagctgcca tcagccatgc gctgctgagt tccccgcgcc agcggggata       60

aaccgatgac tgtcccagcg agtggcttct ctcagac                                97


<210>  704
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa208F

<400>  704
accgaacact cagtgtcccg ctggccaggg ccaccggagt tccccgcgcc agcggggata       60

aaccggagaa gaagttcagt tcagtgacag gtgagcc                                97


<210>  705
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa209F

<400>  705
accgctcagc cccagccctt gaccctcccc agacacgagt tccccgcgcc agcggggata       60

aaccggggat gcttccgcct ttccggggct gctggcc                                97


<210>  706
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa210F

<400>  706
accgttccat gcctgcaggc atcgttctgc catcacgagt tccccgcgcc agcggggata       60

aaccggtcgg gggagagggc caacaactgt ccctcct                                97


<210>  707
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa211F

<400>  707
accgctgaat ggaatctctc tcggagcagg cagccagagt tccccgcgcc agcggggata       60

aaccggaagc tgataggcag gactggagtg ttagcac                                97


<210>  708
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa212F

<400>  708
accggaaagt tcctgtggag ctgagactgt tttcacgagt tccccgcgcc agcggggata       60

aaccggctgg accactcaca gcagatttca ttgtcaa                                97


<210>  709
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa213F

<400>  709
accggggcgc gcggaatcct ggctgggagc tgggaggagt tccccgcgcc agcggggata       60

aaccggcgcc gccggcgtgg accgcgcacg gcctcta                                97


<210>  710
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa214F

<400>  710
accgacagag gagtcctcct cgatgtagtc gacatggagt tccccgcgcc agcggggata       60

aaccgaatac cagccccccg gtaagacccc catctgt                                97


<210>  711
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa215F

<400>  711
accgagctca ataaaagtca ttctgcccac ggacatgagt tccccgcgcc agcggggata       60

aaccggatag gggagggggc ggtaggggct gcaggga                                97


<210>  712
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa216F

<400>  712
accgcctgca ggcatcgttc tgccatcact caccgagagt tccccgcgcc agcggggata       60

aaccggcatg gtcgggggag agggccaaca actgtcc                                97


<210>  713
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa217F

<400>  713
accgaggagc ccagccgggt gaagtaagaa gaggctgagt tccccgcgcc agcggggata       60

aaccggcaga acgatgcctg caggcatgga acttttt                                97


<210>  714
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa218F

<400>  714
accgctgaat ggaatctctc tcggagcagg cagccagagt tccccgcgcc agcggggata       60

aaccgctgat aggcaggact ggagtgttag caccagt                                97


<210>  715
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa219F

<400>  715
accgctgcca tcagccatgc gctgcttgca aagaacgagt tccccgcgcc agcggggata       60

aaccgaaaga tgactgtccc agcgagtggc ttctctc                                97


<210>  716
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa220F

<400>  716
accgcccccc accacgaagt gcagcttcct ctgcctgagt tccccgcgcc agcggggata       60

aaccgcccct catcacctgg gagaaggacg gccagca                                97


<210>  717
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa221F

<400>  717
accgactgtc acacttgctg gcctgctcga cgaacagagt tccccgcgcc agcggggata       60

aaccgcgcag cctgcgcgtg ctcaactgcc aagggaa                                97


<210>  718
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa222F

<400>  718
accgctcagc cccagccctt gaccctcccc agacacgagt tccccgcgcc agcggggata       60

aaccgcttcc gcctttccgg ggctgctggc ctggccc                                97


<210>  719
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa223F

<400>  719
accgcatctc cgccaggcca gtgaatcagg cctggggagt tccccgcgcc agcggggata       60

aaccgcaagc agacatttat cttttgggtc tgtcctc                                97


<210>  720
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa224F

<400>  720
accggacgaa aaagaaaggc gagcgagcag cagagcgagt tccccgcgcc agcggggata       60

aaccgtctga ttagcaggag cctgattggc tggctgc                                97


<210>  721
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa129R

<400>  721
actcgagggg ccgggattcc atgctccttg actttgcggt ttatccccgc tggcgcgggg       60

aactcacagg gaggccagca tccacgcttc ctgctgc                                97


<210>  722
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa130R

<400>  722
actcatgggt tgtcagggtc attagacaca ggaagccggt ttatccccgc tggcgcgggg       60

aactcagcaa tgctcagctc ataatgatgt caagcac                                97


<210>  723
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa131R

<400>  723
actcggctca cctgtcactg aactgaactt cttctccggt ttatccccgc tggcgcgggg       60

aactccactg tgaggccatc ggccacccaa ggcctac                                97


<210>  724
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa132R

<400>  724
actcagcact gcactgctct gatggtaagg tgatgccggt ttatccccgc tggcgcgggg       60

aactcgggcc tcacctagct gtgcaacaca gacaagt                                97


<210>  725
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa133R

<400>  725
actcggccag cagccccgga aaggcggaag catccccggt ttatccccgc tggcgcgggg       60

aactcaatgg ttccgacttg tccctctctc agccctc                                97


<210>  726
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa134R

<400>  726
actcattaga cacaggaagc cattcataaa actggccggt ttatccccgc tggcgcgggg       60

aactccaggt gatttccgag ctcagcaatg ctcagct                                97


<210>  727
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa135R

<400>  727
actcacaatg gagttactta cataagtgat caggaccggt ttatccccgc tggcgcgggg       60

aactcatact gtggttgcaa ttccctatgg aagtaga                                97


<210>  728
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa136R

<400>  728
actcgctgcg cgatgggcat cttaggggtg tacatgcggt ttatccccgc tggcgcgggg       60

aactcctgtg tggaggagga catccagggg catgtca                                97


<210>  729
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa137R

<400>  729
actctggctc accagctcca gcaggtcgcc actcatcggt ttatccccgc tggcgcgggg       60

aactcacctc accaagatcc tgcatgtctt ccatggc                                97


<210>  730
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa138R

<400>  730
actcgggtgg ctcaccagct ccagcaggtc gccactcggt ttatccccgc tggcgcgggg       60

aactctcacc aagatcctgc atgtcttcca tggcctt                                97


<210>  731
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa139R

<400>  731
actctaagcc tccattaatc agggagcccc caggggcggt ttatccccgc tggcgcgggg       60

aactcggggg gtgagtgtga aaggtgctga tggccct                                97


<210>  732
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa140R

<400>  732
actcccactc gctgggacag tcatctttct tgcatgcggt ttatccccgc tggcgcgggg       60

aactccttcc tggagcttcc tgagaccttc tgttcag                                97


<210>  733
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa141R

<400>  733
actccagtac ccgctggtcc tcagggaacc aggcctcggt ttatccccgc tggcgcgggg       60

aactcaccct ggccgagttg aggcagagac tgatcca                                97


<210>  734
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa142R

<400>  734
actcccctcc cctatccatg ggaagaatcc tgcctccggt ttatccccgc tggcgcgggg       60

aactctgact tttattgagc tcttgttccg tgccagg                                97


<210>  735
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa143R

<400>  735
actccagggc tgcgcgatgg gcatcttagg ggtgtacggt ttatccccgc tggcgcgggg       60

aactcctgtg tggaggagga catccagggg catgtca                                97


<210>  736
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa144R

<400>  736
actcctcctt cttctagctc ttgagcttgt ttgaaccggt ttatccccgc tggcgcgggg       60

aactcttgta tgtgcatgca ctgaattctc agagaaa                                97


<210>  737
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa145R

<400>  737
actcgggcca ggccagcagc cccggaaagg cggaagcggt ttatccccgc tggcgcgggg       60

aactcaatgg ttccgacttg tccctctctc agccctc                                97


<210>  738
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa146R

<400>  738
actcttggca ggcacgcccc ctctggttcc aggtttcggt ttatccccgc tggcgcgggg       60

aactcagcca acccgctcca ctacccggca gggtaca                                97


<210>  739
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa147R

<400>  739
actcagttga atgagaacaa atcagcactt acttggcggt ttatccccgc tggcgcgggg       60

aactcggtct tagatggtac gcgttgctat acagaat                                97


<210>  740
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa148R

<400>  740
actcgaagcc actcgctggg acagtcatct ttcttgcggt ttatccccgc tggcgcgggg       60

aactccttcc tggagcttcc tgagaccttc tgttcag                                97


<210>  741
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa149R

<400>  741
actctggctc accagctcca gcaggtcgcc actcatcggt ttatccccgc tggcgcgggg       60

aactcgggga tacctcacca agatcctgca tgtcttc                                97


<210>  742
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa150R

<400>  742
actcacctgc tcctgagggg ccgggattcc atgctccggt ttatccccgc tggcgcgggg       60

aactcacagg gaggccagca tccacgcttc ctgctgc                                97


<210>  743
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa151R

<400>  743
actcttgctg agcaaggaaa gaaatccgtc tccctccggt ttatccccgc tggcgcgggg       60

aactcaactc gggctccgct gacagtacag tccagtt                                97


<210>  744
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa152R

<400>  744
actcttacga gggctcctct gacacagcag ctccttcggt ttatccccgc tggcgcgggg       60

aactcctcag agaaacttcc agtcgaggcc aagttgc                                97


<210>  745
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa153R

<400>  745
actcgtggaa ggtggctgtg gttccgtgct cgggtgcggt ttatccccgc tggcgcgggg       60

aactcgagga cggcgactac gaggagctgg tgctagc                                97


<210>  746
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa154R

<400>  746
actcacctat gagggtgccg ctaaccgtgc ccttcccggt ttatccccgc tggcgcgggg       60

aactcggccg ggatgccggc gtggccaagg gtgccag                                97


<210>  747
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa155R

<400>  747
actcagtcgg aaccatttta aagctcagcc ccagcccggt ttatccccgc tggcgcgggg       60

aactccgcag gcctcccagg agctccagtg acagccc                                97


<210>  748
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa156R

<400>  748
actctcctgc ctatcagctt ccatcagccc ctctcacggt ttatccccgc tggcgcgggg       60

aactccgaga gagattccat tcagcttacc ccccacc                                97


<210>  749
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa157R

<400>  749
actctggctc accagctcca gcaggtcgcc actcatcggt ttatccccgc tggcgcgggg       60

aactccgccg gggatacctc accaagatcc tgcatgt                                97


<210>  750
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa158R

<400>  750
actcgggctt ctccacagtt agctggagat gagggccggt ttatccccgc tggcgcgggg       60

aactcgggga gggggcggta ggggctgcag ggacaaa                                97


<210>  751
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa159R

<400>  751
actcgttgtc agggtcatta gacacaggaa gccattcggt ttatccccgc tggcgcgggg       60

aactccaggt gatttccgag ctcagcaatg ctcagct                                97


<210>  752
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa160R

<400>  752
actcttaaag cggttacaag cttgcaccgt gctgggcggt ttatccccgc tggcgcgggg       60

aactccacct gctttccaga gagatgaatg aaacagt                                97


<210>  753
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa161R

<400>  753
actcctcctg aggggccggg attccatgct ccttgacggt ttatccccgc tggcgcgggg       60

aactcgtgcg tgggccacag ggaggccagc atccacg                                97


<210>  754
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa162R

<400>  754
actcgtctga gagaagccac tcgctgggac agtcatcggt ttatccccgc tggcgcgggg       60

aactccttcc tggagcttcc tgagaccttc tgttcag                                97


<210>  755
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa163R

<400>  755
actccagggt ttcttacctt ggatcactaa agatgccggt ttatccccgc tggcgcgggg       60

aactcttagc ggtgggtctc aaggggaatt cagctgc                                97


<210>  756
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa164R

<400>  756
actccagcta actgaaagag aaaacacgcg gacgtccggt ttatccccgc tggcgcgggg       60

aactcattta tttccccctc cccactccac acacacc                                97


<210>  757
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa165R

<400>  757
actcatgggt tgtcagggtc attagacaca ggaagccggt ttatccccgc tggcgcgggg       60

aactccaggt gatttccgag ctcagcaatg ctcagct                                97


<210>  758
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa166R

<400>  758
actctcaaaa atgttgcagg gctgcgcgat gggcatcggt ttatccccgc tggcgcgggg       60

aactcctgtg tggaggagga catccagggg catgtca                                97


<210>  759
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa167R

<400>  759
actcgaggga gggtgtactg tggacacgca taaacccggt ttatccccgc tggcgcgggg       60

aactctctgt caggctgtca ggttgtagca acctctt                                97


<210>  760
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa168R

<400>  760
actcacagat taatattgtc ttcctctcaa attttacggt ttatccccgc tggcgcgggg       60

aactccccct catgaaatgc cactcacccc gggctac                                97


<210>  761
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa169R

<400>  761
actctagagg ccgtgcgcgg tccacgccgg cggcgccggt ttatccccgc tggcgcgggg       60

aactcccgcg cgccccttca cgcgccctgc tcctgaa                                97


<210>  762
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa170R

<400>  762
actctcctcc tcgggcacat tctcgaagtc ggtgaccggt ttatccccgc tggcgcgggg       60

aactcagcct ggtggaggtg tatctcctag acaccag                                97


<210>  763
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa171R

<400>  763
actcgctgcg catgctggca cccttggcca cgccggcggt ttatccccgc tggcgcgggg       60

aactctgttc gtcgagcagg ccagcaagtg tgacagt                                97


<210>  764
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa172R

<400>  764
actcccgggt agtggagcgg gttggctgag acagtgcggt ttatccccgc tggcgcgggg       60

aactcctagc aacacccaaa ggtggcctgc ggggagc                                97


<210>  765
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa173R

<400>  765
actcgggtgg ctcaccagct ccagcaggtc gccactcggt ttatccccgc tggcgcgggg       60

aactcctgcc cgccggggat acctcaccaa gatcctg                                97


<210>  766
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa174R

<400>  766
actcggcgga agcatcccca tcccctcgtg ccaggccggt ttatccccgc tggcgcgggg       60

aactcgtgtc tggggagggt caagggctgg ggctgag                                97


<210>  767
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa175R

<400>  767
actcccctcc cctatccatg ggaagaatcc tgcctccggt ttatccccgc tggcgcgggg       60

aactcatgtc cgtgggcaga atgactttta ttgagct                                97


<210>  768
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa176R

<400>  768
actctcaaca accagggttg ttcctttggc ttggcacggt ttatccccgc tggcgcgggg       60

aactcatgtc aagcaccatg gccagtttta tgaatgg                                97


<210>  769
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa177R

<400>  769
actcctcctg aggggccggg attccatgct ccttgacggt ttatccccgc tggcgcgggg       60

aactccccaa ccagtgcgtg ggccacaggg aggccag                                97


<210>  770
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa178R

<400>  770
actcagtgtg ccaggagttg cccgacggca gcattccggt ttatccccgc tggcgcgggg       60

aactcgatgt gacagcaggc agaggagcac ttagcag                                97


<210>  771
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa179R

<400>  771
actcggagac agagtcgtat cccaaggcat tggtggcggt ttatccccgc tggcgcgggg       60

aactcattct tctacagcca gatgattcct tacagat                                97


<210>  772
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa180R

<400>  772
actccagtgc tctgttgtgg gcagcagggc tctgagcggt ttatccccgc tggcgcgggg       60

aactcgtggg gcagggtgag caggggcttc caggctg                                97


<210>  773
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa181R

<400>  773
actctccctg cagcccctac cgccccctcc cctatccggt ttatccccgc tggcgcgggg       60

aactctgact tttattgagc tcttgttccg tgccagg                                97


<210>  774
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa182R

<400>  774
actctgctgt gagtggtcca gccattctca gtatctcggt ttatccccgc tggcgcgggg       60

aactcgtgaa aacagtctca gctccacagg aactttc                                97


<210>  775
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa183R

<400>  775
actcccactc gctgggacag tcatctttct tgcatgcggt ttatccccgc tggcgcgggg       60

aactcagcag cgcatggctg atggcagctt cctggag                                97


<210>  776
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa184R

<400>  776
actcacgcct gcatccgagg gcttgaggcg gtggatcggt ttatccccgc tggcgcgggg       60

aactcctcat cacctgggag aaggacggcc agcacct                                97


<210>  777
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa185R

<400>  777
actccctctt cacctgctcc tgaggggccg ggattccggt ttatccccgc tggcgcgggg       60

aactcgtgcg tgggccacag ggaggccagc atccacg                                97


<210>  778
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa186R

<400>  778
actcctggct agatgccatc cagaaagcta agcctccggt ttatccccgc tggcgcgggg       60

aactcggggg gtgagtgtga aaggtgctga tggccct                                97


<210>  779
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa187R

<400>  779
actctgccag gagttgcccg acggcagcat tccatgcggt ttatccccgc tggcgcgggg       60

aactccagta ctggatgtga cagcaggcag aggagca                                97


<210>  780
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa188R

<400>  780
actccagtca aaaatgttgc agggctgcgc gatgggcggt ttatccccgc tggcgcgggg       60

aactccagtt tcctgtgtgg aggaggacat ccagggg                                97


<210>  781
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa189R

<400>  781
actcacagat gggggtctta ccggggggct ggtattcggt ttatccccgc tggcgcgggg       60

aactcatcga ggaggactcc tctgtctttg cccagag                                97


<210>  782
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa190R

<400>  782
actcctgcag gcatcgttct gccatcactc accgagcggt ttatccccgc tggcgcgggg       60

aactcagcct cttcttactt cacccggctg ggctcct                                97


<210>  783
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa191R

<400>  783
actcgtacat gcatttccac tcttccactg aagtgacggt ttatccccgc tggcgcgggg       60

aactctggac cgcgtgctcc tcctcgtgtg ggggggg                                97


<210>  784
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa192R

<400>  784
actcccaggc tggggggcaa ttaaagcggt tacaagcggt ttatccccgc tggcgcgggg       60

aactccacct gctttccaga gagatgaatg aaacagt                                97


<210>  785
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa193R

<400>  785
actctcctgc ctatcagctt ccatcagccc ctctcacggt ttatccccgc tggcgcgggg       60

aactcgattg gctggctgcc tgctccgaga gagattc                                97


<210>  786
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa194R

<400>  786
actcagtgtg ccaggagttg cccgacggca gcattccggt ttatccccgc tggcgcgggg       60

aactccagta ctggatgtga cagcaggcag aggagca                                97


<210>  787
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa195R

<400>  787
actcttacga gggctcctct gacacagcag ctccttcggt ttatccccgc tggcgcgggg       60

aactcttgta tgtgcatgca ctgaattctc agagaaa                                97


<210>  788
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa196R

<400>  788
actcggcatt ggtggcattg caagtgtaga aacccacggt ttatccccgc tggcgcgggg       60

aactcggtct atatttcttt tctgtcgctc caggatt                                97


<210>  789
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa197R

<400>  789
actcttgagc acgcgcaggc tgcgcatgct ggcacccggt ttatccccgc tggcgcgggg       60

aactctgttc gtcgagcagg ccagcaagtg tgacagt                                97


<210>  790
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa198R

<400>  790
actcgttggc cctctccccc gaccatgcct tagaagcggt ttatccccgc tggcgcgggg       60

aactctcggt gagtgatggc agaacgatgc ctgcagg                                97


<210>  791
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa199R

<400>  791
actcaacgtt tgtttgtttt tattttaaaa agtcaccggt ttatccccgc tggcgcgggg       60

aactcttttt acagccaact tttctagacc tgttttg                                97


<210>  792
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa200R

<400>  792
actcgagaga agccactcgc tgggacagtc atctttcggt ttatccccgc tggcgcgggg       60

aactcagcag cgcatggctg atggcagctt cctggag                                97


<210>  793
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa201R

<400>  793
actccctctt cacctgctcc tgaggggccg ggattccggt ttatccccgc tggcgcgggg       60

aactccccaa ccagtgcgtg ggccacaggg aggccag                                97


<210>  794
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa202R

<400>  794
actcggcttt gtttttgggc tacagcctcc tgtgtgcggt ttatccccgc tggcgcgggg       60

aactcctctc ttgcaatctc tttccagtgc acagtga                                97


<210>  795
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa203R

<400>  795
actccaccgt gctgggcttg ggctggcgac acagctcggt ttatccccgc tggcgcgggg       60

aactcacatg tggggtcggc ctacagacca gagacgt                                97


<210>  796
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa204R

<400>  796
actcccactc gctgggacag tcatctttct tgcatgcggt ttatccccgc tggcgcgggg       60

aactcgttct ttgcaagcag cgcatggctg atggcag                                97


<210>  797
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa205R

<400>  797
actcatcact caccgagctt cctggtctgt gttccccggt ttatccccgc tggcgcgggg       60

aactcacgca gattgggctg gctctgaagc caagcct                                97


<210>  798
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa206R

<400>  798
actccagtca aaaatgttgc agggctgcgc gatgggcggt ttatccccgc tggcgcgggg       60

aactccagag ccgggcagtt tcctgtgtgg aggagga                                97


<210>  799
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa207R

<400>  799
actcgtctga gagaagccac tcgctgggac agtcatcggt ttatccccgc tggcgcgggg       60

aactcagcag cgcatggctg atggcagctt cctggag                                97


<210>  800
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa208R

<400>  800
actcggctca cctgtcactg aactgaactt cttctccggt ttatccccgc tggcgcgggg       60

aactccggtg gccctggcca gcgggacact gagtgtt                                97


<210>  801
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa209R

<400>  801
actcggccag cagccccgga aaggcggaag catccccggt ttatccccgc tggcgcgggg       60

aactcgtgtc tggggagggt caagggctgg ggctgag                                97


<210>  802
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa210R

<400>  802
actcaggagg gacagttgtt ggccctctcc cccgaccggt ttatccccgc tggcgcgggg       60

aactcgtgat ggcagaacga tgcctgcagg catggaa                                97


<210>  803
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa211R

<400>  803
actcgtgcta acactccagt cctgcctatc agcttccggt ttatccccgc tggcgcgggg       60

aactctggct gcctgctccg agagagattc cattcag                                97


<210>  804
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa212R

<400>  804
actcttgaca atgaaatctg ctgtgagtgg tccagccggt ttatccccgc tggcgcgggg       60

aactcgtgaa aacagtctca gctccacagg aactttc                                97


<210>  805
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa213R

<400>  805
actctagagg ccgtgcgcgg tccacgccgg cggcgccggt ttatccccgc tggcgcgggg       60

aactcctccc agctcccagc caggattccg cgcgccc                                97


<210>  806
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa214R

<400>  806
actcacagat gggggtctta ccggggggct ggtattcggt ttatccccgc tggcgcgggg       60

aactccatgt cgactacatc gaggaggact cctctgt                                97


<210>  807
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa215R

<400>  807
actctccctg cagcccctac cgccccctcc cctatccggt ttatccccgc tggcgcgggg       60

aactcatgtc cgtgggcaga atgactttta ttgagct                                97


<210>  808
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa216R

<400>  808
actcggacag ttgttggccc tctcccccga ccatgccggt ttatccccgc tggcgcgggg       60

aactctcggt gagtgatggc agaacgatgc ctgcagg                                97


<210>  809
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa217R

<400>  809
actcaaaaag ttccatgcct gcaggcatcg ttctgccggt ttatccccgc tggcgcgggg       60

aactcagcct cttcttactt cacccggctg ggctcct                                97


<210>  810
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa218R

<400>  810
actcactggt gctaacactc cagtcctgcc tatcagcggt ttatccccgc tggcgcgggg       60

aactctggct gcctgctccg agagagattc cattcag                                97


<210>  811
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa219R

<400>  811
actcgagaga agccactcgc tgggacagtc atctttcggt ttatccccgc tggcgcgggg       60

aactcgttct ttgcaagcag cgcatggctg atggcag                                97


<210>  812
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa220R

<400>  812
actctgctgg ccgtccttct cccaggtgat gaggggcggt ttatccccgc tggcgcgggg       60

aactcaggca gaggaagctg cacttcgtgg tgggggg                                97


<210>  813
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa221R

<400>  813
actcttccct tggcagttga gcacgcgcag gctgcgcggt ttatccccgc tggcgcgggg       60

aactctgttc gtcgagcagg ccagcaagtg tgacagt                                97


<210>  814
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa222R

<400>  814
actcgggcca ggccagcagc cccggaaagg cggaagcggt ttatccccgc tggcgcgggg       60

aactcgtgtc tggggagggt caagggctgg ggctgag                                97


<210>  815
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa223R

<400>  815
actcgaggac agacccaaaa gataaatgtc tgcttgcggt ttatccccgc tggcgcgggg       60

aactccccag gcctgattca ctggcctggc ggagatg                                97


<210>  816
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa224R

<400>  816
actcgcagcc agccaatcag gctcctgcta atcagacggt ttatccccgc tggcgcgggg       60

aactcgctct gctgctcgct cgcctttctt tttcgtc                                97


<210>  817
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  817

Gly Gly Gly Gly Ser 
1               5   


<210>  818
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  818

Thr Gly Pro Gly Ala Ala Ala Arg 
1               5               


<210>  819
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  819

Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly 
1               5                   10  


<210>  820
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  820

Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Ser 
1               5                   10                  15  


<210>  821
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  821

Ala Asp Pro Thr Asn Arg Ala Lys Gly Leu Glu Ala Val Ser Val Ala 
1               5                   10                  15      


Ser 
    


<210>  822
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  822

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210>  823
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  823

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly 
            20                  25                  30          


Ser Ser Gly Gly Ser Gly Ser Ser 
        35                  40  


<210>  824
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  824

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly 
            20                  25                  30          


Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly Ser Gly Ser Ser Gly Gly 
        35                  40                  45              


Ser Gly 
    50  


<210>  825
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa129_F_ilmn (Illumina)

<400>  825
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  826
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa130_F_ilmn (Illumina)

<400>  826
cactctttcc ctacacgacg ctcttccgat cttgctctgg tttcatgttt gg               52


<210>  827
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa131_F_ilmn (Illumina)

<400>  827
cactctttcc ctacacgacg ctcttccgat ctccagcagc tctcagcctc                  50


<210>  828
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa132_F_ilmn (Illumina)

<400>  828
cactctttcc ctacacgacg ctcttccgat ctctccaccc ttgacttggc ta               52


<210>  829
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa133_F_ilmn (Illumina)

<400>  829
cactctttcc ctacacgacg ctcttccgat ctcaggagct ccagtgacag c                51


<210>  830
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa134_F_ilmn (Illumina)

<400>  830
cactctttcc ctacacgacg ctcttccgat cttgctctgg tttcatgttt gg               52


<210>  831
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa135_F_ilmn (Illumina)

<400>  831
cactctttcc ctacacgacg ctcttccgat cttttaaggt atggaagtca gtgcc            55


<210>  832
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa136_F_ilmn (Illumina)

<400>  832
cactctttcc ctacacgacg ctcttccgat ctttgcttct gtaggtggga gg               52


<210>  833
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa137_F_ilmn (Illumina)

<400>  833
cactctttcc ctacacgacg ctcttccgat ctgtggtgct gaaggaggag ac               52


<210>  834
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa138_F_ilmn (Illumina)

<400>  834
cactctttcc ctacacgacg ctcttccgat ctgtggtgct gaaggaggag ac               52


<210>  835
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa139_F_ilmn (Illumina)

<400>  835
cactctttcc ctacacgacg ctcttccgat cttcaatcct caggtctcca cc               52


<210>  836
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa140_F_ilmn (Illumina)

<400>  836
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  837
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa141_F_ilmn (Illumina)

<400>  837
cactctttcc ctacacgacg ctcttccgat ctccatcttt caccattcac cc               52


<210>  838
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa142_F_ilmn (Illumina)

<400>  838
cactctttcc ctacacgacg ctcttccgat ctgggcattt caccattcaa ac               52


<210>  839
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa143_F_ilmn (Illumina)

<400>  839
cactctttcc ctacacgacg ctcttccgat ctttgcttct gtaggtggga gg               52


<210>  840
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa144_F_ilmn (Illumina)

<400>  840
cactctttcc ctacacgacg ctcttccgat ctgaggcagc aatttaccca aa               52


<210>  841
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa145_F_ilmn (Illumina)

<400>  841
cactctttcc ctacacgacg ctcttccgat ctcaggagct ccagtgacag c                51


<210>  842
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa146_F_ilmn (Illumina)

<400>  842
cactctttcc ctacacgacg ctcttccgat cttgtgctag caacacccaa ag               52


<210>  843
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa147_F_ilmn (Illumina)

<400>  843
cactctttcc ctacacgacg ctcttccgat cttgttcact caagtgccaa gc               52


<210>  844
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa148_F_ilmn (Illumina)

<400>  844
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  845
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa149_F_ilmn (Illumina)

<400>  845
cactctttcc ctacacgacg ctcttccgat ctgtggtgct gaaggaggag ac               52


<210>  846
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa150_F_ilmn (Illumina)

<400>  846
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  847
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa151_F_ilmn (Illumina)

<400>  847
cactctttcc ctacacgacg ctcttccgat ctagcaccgc actgtcacat ta               52


<210>  848
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa152_F_ilmn (Illumina)

<400>  848
cactctttcc ctacacgacg ctcttccgat ctaatcccag attggttcta acctc            55


<210>  849
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa153_F_ilmn (Illumina)

<400>  849
cactctttcc ctacacgacg ctcttccgat ctgacagcaa cctctcccct g                51


<210>  850
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa154_F_ilmn (Illumina)

<400>  850
cactctttcc ctacacgacg ctcttccgat ctagtgtgac agtcatggca cc               52


<210>  851
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa155_F_ilmn (Illumina)

<400>  851
cactctttcc ctacacgacg ctcttccgat ctgtcagcac tacaggcagc ac               52


<210>  852
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa156_F_ilmn (Illumina)

<400>  852
cactctttcc ctacacgacg ctcttccgat cttctgtcct cctggctttg tt               52


<210>  853
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa157_F_ilmn (Illumina)

<400>  853
cactctttcc ctacacgacg ctcttccgat ctgtggtgct gaaggaggag ac               52


<210>  854
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa158_F_ilmn (Illumina)

<400>  854
cactctttcc ctacacgacg ctcttccgat cttcaatcct caggtctcca cc               52


<210>  855
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa159_F_ilmn (Illumina)

<400>  855
cactctttcc ctacacgacg ctcttccgat cttgctctgg tttcatgttt gg               52


<210>  856
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa160_F_ilmn (Illumina)

<400>  856
cactctttcc ctacacgacg ctcttccgat cttcggccta cagaccagag ac               52


<210>  857
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa161_F_ilmn (Illumina)

<400>  857
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  858
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa162_F_ilmn (Illumina)

<400>  858
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  859
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa163_F_ilmn (Illumina)

<400>  859
cactctttcc ctacacgacg ctcttccgat ctactgacgc atcacatctt gg               52


<210>  860
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa164_F_ilmn (Illumina)

<400>  860
cactctttcc ctacacgacg ctcttccgat ctatctcgct gctgtggaac tt               52


<210>  861
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa165_F_ilmn (Illumina)

<400>  861
cactctttcc ctacacgacg ctcttccgat cttgctctgg tttcatgttt gg               52


<210>  862
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa166_F_ilmn (Illumina)

<400>  862
cactctttcc ctacacgacg ctcttccgat ctttgcttct gtaggtggga gg               52


<210>  863
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa167_F_ilmn (Illumina)

<400>  863
cactctttcc ctacacgacg ctcttccgat cttaggacct ttgctgctcc ac               52


<210>  864
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa168_F_ilmn (Illumina)

<400>  864
cactctttcc ctacacgacg ctcttccgat ctaatcctca ttaagccgag ca               52


<210>  865
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa169_F_ilmn (Illumina)

<400>  865
cactctttcc ctacacgacg ctcttccgat ctgtctgagc ctggaggagt ga               52


<210>  866
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa170_F_ilmn (Illumina)

<400>  866
cactctttcc ctacacgacg ctcttccgat ctacaaatgt cgccttggaa ag               52


<210>  867
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa171_F_ilmn (Illumina)

<400>  867
cactctttcc ctacacgacg ctcttccgat ctgggtcttt ctcatgtggt cc               52


<210>  868
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa172_F_ilmn (Illumina)

<400>  868
cactctttcc ctacacgacg ctcttccgat ctactctgct ctatgccagg ct               52


<210>  869
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa173_F_ilmn (Illumina)

<400>  869
cactctttcc ctacacgacg ctcttccgat ctgtggtgct gaaggaggag ac               52


<210>  870
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa174_F_ilmn (Illumina)

<400>  870
cactctttcc ctacacgacg ctcttccgat ctcaggagct ccagtgacag c                51


<210>  871
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa175_F_ilmn (Illumina)

<400>  871
cactctttcc ctacacgacg ctcttccgat ctgggcattt caccattcaa ac               52


<210>  872
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa176_F_ilmn (Illumina)

<400>  872
cactctttcc ctacacgacg ctcttccgat ctagaagcag gtgatttccg ag               52


<210>  873
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa177_F_ilmn (Illumina)

<400>  873
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  874
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa178_F_ilmn (Illumina)

<400>  874
cactctttcc ctacacgacg ctcttccgat ctgctgatag gcaggactgg ag               52


<210>  875
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa179_F_ilmn (Illumina)

<400>  875
cactctttcc ctacacgacg ctcttccgat ctacaccctg aggttccttc ct               52


<210>  876
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa180_F_ilmn (Illumina)

<400>  876
cactctttcc ctacacgacg ctcttccgat ctaggcacac aacattgcag aa               52


<210>  877
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa181_F_ilmn (Illumina)

<400>  877
cactctttcc ctacacgacg ctcttccgat ctgggcattt caccattcaa ac               52


<210>  878
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa182_F_ilmn (Illumina)

<400>  878
cactctttcc ctacacgacg ctcttccgat ctatgaaatg tgcttgcctg tg               52


<210>  879
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa183_F_ilmn (Illumina)

<400>  879
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  880
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa184_F_ilmn (Illumina)

<400>  880
cactctttcc ctacacgacg ctcttccgat ctcatacaga ctcgcaggca ga               52


<210>  881
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa185_F_ilmn (Illumina)

<400>  881
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  882
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa186_F_ilmn (Illumina)

<400>  882
cactctttcc ctacacgacg ctcttccgat cttcaatcct caggtctcca cc               52


<210>  883
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa187_F_ilmn (Illumina)

<400>  883
cactctttcc ctacacgacg ctcttccgat ctgctgatag gcaggactgg ag               52


<210>  884
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa188_F_ilmn (Illumina)

<400>  884
cactctttcc ctacacgacg ctcttccgat ctttgcttct gtaggtggga gg               52


<210>  885
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa189_F_ilmn (Illumina)

<400>  885
cactctttcc ctacacgacg ctcttccgat ctcttctgca ggccttgaag tt               52


<210>  886
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa190_F_ilmn (Illumina)

<400>  886
cactctttcc ctacacgacg ctcttccgat ctgcaggaac tgagccagaa ac               52


<210>  887
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa191_F_ilmn (Illumina)

<400>  887
cactctttcc ctacacgacg ctcttccgat ctttgcttct gtaggtggga gg               52


<210>  888
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa192_F_ilmn (Illumina)

<400>  888
cactctttcc ctacacgacg ctcttccgat cttcggccta cagaccagag ac               52


<210>  889
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa193_F_ilmn (Illumina)

<400>  889
cactctttcc ctacacgacg ctcttccgat cttctgtcct cctggctttg tt               52


<210>  890
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa194_F_ilmn (Illumina)

<400>  890
cactctttcc ctacacgacg ctcttccgat ctgctgatag gcaggactgg ag               52


<210>  891
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa195_F_ilmn (Illumina)

<400>  891
cactctttcc ctacacgacg ctcttccgat ctaatcccag attggttcta acctc            55


<210>  892
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa196_F_ilmn (Illumina)

<400>  892
cactctttcc ctacacgacg ctcttccgat ctacaccctg aggttccttc ct               52


<210>  893
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa197_F_ilmn (Illumina)

<400>  893
cactctttcc ctacacgacg ctcttccgat ctcatgtggt ccttgtgttc gt               52


<210>  894
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa198_F_ilmn (Illumina)

<400>  894
cactctttcc ctacacgacg ctcttccgat ctggtaacag tgaggctggg aa               52


<210>  895
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa199_F_ilmn (Illumina)

<400>  895
cactctttcc ctacacgacg ctcttccgat ctggtctgtc ctctctgttg cc               52


<210>  896
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa200_F_ilmn (Illumina)

<400>  896
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  897
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa201_F_ilmn (Illumina)

<400>  897
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  898
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa202_F_ilmn (Illumina)

<400>  898
cactctttcc ctacacgacg ctcttccgat ctcaaggctt tgcctacgag tc               52


<210>  899
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa203_F_ilmn (Illumina)

<400>  899
cactctttcc ctacacgacg ctcttccgat ctggaaattg gcaagtggag tc               52


<210>  900
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa204_F_ilmn (Illumina)

<400>  900
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  901
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa205_F_ilmn (Illumina)

<400>  901
cactctttcc ctacacgacg ctcttccgat ctgcaggaac tgagccagaa ac               52


<210>  902
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa206_F_ilmn (Illumina)

<400>  902
cactctttcc ctacacgacg ctcttccgat ctttgcttct gtaggtggga gg               52


<210>  903
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa207_F_ilmn (Illumina)

<400>  903
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  904
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa208_F_ilmn (Illumina)

<400>  904
cactctttcc ctacacgacg ctcttccgat ctccagcagc tctcagcctc                  50


<210>  905
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa209_F_ilmn (Illumina)

<400>  905
cactctttcc ctacacgacg ctcttccgat ctcaggagct ccagtgacag c                51


<210>  906
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa210_F_ilmn (Illumina)

<400>  906
cactctttcc ctacacgacg ctcttccgat ctggtaacag tgaggctggg aa               52


<210>  907
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa211_F_ilmn (Illumina)

<400>  907
cactctttcc ctacacgacg ctcttccgat cttctgtcct cctggctttg tt               52


<210>  908
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa212_F_ilmn (Illumina)

<400>  908
cactctttcc ctacacgacg ctcttccgat ctatgaaatg tgcttgcctg tg               52


<210>  909
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa213_F_ilmn (Illumina)

<400>  909
cactctttcc ctacacgacg ctcttccgat ctgtctgagc ctggaggagt ga               52


<210>  910
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa214_F_ilmn (Illumina)

<400>  910
cactctttcc ctacacgacg ctcttccgat ctcttctgca ggccttgaag tt               52


<210>  911
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa215_F_ilmn (Illumina)

<400>  911
cactctttcc ctacacgacg ctcttccgat ctgggcattt caccattcaa ac               52


<210>  912
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa216_F_ilmn (Illumina)

<400>  912
cactctttcc ctacacgacg ctcttccgat ctggtaacag tgaggctggg aa               52


<210>  913
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa217_F_ilmn (Illumina)

<400>  913
cactctttcc ctacacgacg ctcttccgat ctgcaggaac tgagccagaa ac               52


<210>  914
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa218_F_ilmn (Illumina)

<400>  914
cactctttcc ctacacgacg ctcttccgat cttctgtcct cctggctttg tt               52


<210>  915
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa219_F_ilmn (Illumina)

<400>  915
cactctttcc ctacacgacg ctcttccgat ctccagtgtt ccagaacgtg tg               52


<210>  916
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa220_F_ilmn (Illumina)

<400>  916
cactctttcc ctacacgacg ctcttccgat ctccgccagg aaggtctaca ta               52


<210>  917
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa221_F_ilmn (Illumina)

<400>  917
cactctttcc ctacacgacg ctcttccgat ctcatgtggt ccttgtgttc gt               52


<210>  918
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa222_F_ilmn (Illumina)

<400>  918
cactctttcc ctacacgacg ctcttccgat ctcaggagct ccagtgacag c                51


<210>  919
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa223_F_ilmn (Illumina)

<400>  919
cactctttcc ctacacgacg ctcttccgat ctggtaacag tgaggctggg aa               52


<210>  920
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa224_F_ilmn (Illumina)

<400>  920
cactctttcc ctacacgacg ctcttccgat ctatttccct tctcgctctg ct               52


<210>  921
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa129_R_ilmn (Illumina)

<400>  921
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  922
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa130_R_ilmn (Illumina)

<400>  922
ggagttcaga cgtgtgctct tccgatctca accagggttg ttcctttg                    48


<210>  923
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa131_R_ilmn (Illumina)

<400>  923
ggagttcaga cgtgtgctct tccgatctgt gtgacttggg ccagatgt                    48


<210>  924
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa132_R_ilmn (Illumina)

<400>  924
ggagttcaga cgtgtgctct tccgatctac tcagcaccat ctttccgt                    48


<210>  925
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa133_R_ilmn (Illumina)

<400>  925
ggagttcaga cgtgtgctct tccgatctgg cacccagagt gagtgagt                    48


<210>  926
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa134_R_ilmn (Illumina)

<400>  926
ggagttcaga cgtgtgctct tccgatctca accagggttg ttcctttg                    48


<210>  927
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa135_R_ilmn (Illumina)

<400>  927
ggagttcaga cgtgtgctct tccgatctga ctacaattcc caattcccaa                  50


<210>  928
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa136_R_ilmn (Illumina)

<400>  928
ggagttcaga cgtgtgctct tccgatctga aggcacagtt accggaga                    48


<210>  929
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa137_R_ilmn (Illumina)

<400>  929
ggagttcaga cgtgtgctct tccgatctag caatgggcct actaagca                    48


<210>  930
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa138_R_ilmn (Illumina)

<400>  930
ggagttcaga cgtgtgctct tccgatctag caatgggcct actaagca                    48


<210>  931
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa139_R_ilmn (Illumina)

<400>  931
ggagttcaga cgtgtgctct tccgatctct gtctccagcc tctggcta                    48


<210>  932
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa140_R_ilmn (Illumina)

<400>  932
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  933
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa141_R_ilmn (Illumina)

<400>  933
ggagttcaga cgtgtgctct tccgatctac cctgccatcc tgcttac                     47


<210>  934
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa142_R_ilmn (Illumina)

<400>  934
ggagttcaga cgtgtgctct tccgatctag cacctttcac actcaccc                    48


<210>  935
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa143_R_ilmn (Illumina)

<400>  935
ggagttcaga cgtgtgctct tccgatctga aggcacagtt accggaga                    48


<210>  936
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa144_R_ilmn (Illumina)

<400>  936
ggagttcaga cgtgtgctct tccgatctta cgagggctcc tctgacac                    48


<210>  937
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa145_R_ilmn (Illumina)

<400>  937
ggagttcaga cgtgtgctct tccgatctgg cacccagagt gagtgagt                    48


<210>  938
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa146_R_ilmn (Illumina)

<400>  938
ggagttcaga cgtgtgctct tccgatctgt ttctggctca gttcctgc                    48


<210>  939
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa147_R_ilmn (Illumina)

<400>  939
ggagttcaga cgtgtgctct tccgatctca aagacattga aaccctctgg                  50


<210>  940
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa148_R_ilmn (Illumina)

<400>  940
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  941
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa149_R_ilmn (Illumina)

<400>  941
ggagttcaga cgtgtgctct tccgatctag caatgggcct actaagca                    48


<210>  942
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa150_R_ilmn (Illumina)

<400>  942
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  943
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa151_R_ilmn (Illumina)

<400>  943
ggagttcaga cgtgtgctct tccgatcttt tcctcacaga agccaaca                    48


<210>  944
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa152_R_ilmn (Illumina)

<400>  944
ggagttcaga cgtgtgctct tccgatctcc atgaaagcta caaccagtga                  50


<210>  945
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa153_R_ilmn (Illumina)

<400>  945
ggagttcaga cgtgtgctct tccgatctat ccctacaccc gcacct                      46


<210>  946
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa154_R_ilmn (Illumina)

<400>  946
ggagttcaga cgtgtgctct tccgatctga tggagagaga ccagcgtc                    48


<210>  947
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa155_R_ilmn (Illumina)

<400>  947
ggagttcaga cgtgtgctct tccgatctca tggagggctg agagagg                     47


<210>  948
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa156_R_ilmn (Illumina)

<400>  948
ggagttcaga cgtgtgctct tccgatctcg gaatcagaat cggacact                    48


<210>  949
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa157_R_ilmn (Illumina)

<400>  949
ggagttcaga cgtgtgctct tccgatctag caatgggcct actaagca                    48


<210>  950
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa158_R_ilmn (Illumina)

<400>  950
ggagttcaga cgtgtgctct tccgatcttc cagaaagcta agcctcca                    48


<210>  951
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa159_R_ilmn (Illumina)

<400>  951
ggagttcaga cgtgtgctct tccgatctca accagggttg ttcctttg                    48


<210>  952
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa160_R_ilmn (Illumina)

<400>  952
ggagttcaga cgtgtgctct tccgatctcc actctgagag agcatccc                    48


<210>  953
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa161_R_ilmn (Illumina)

<400>  953
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  954
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa162_R_ilmn (Illumina)

<400>  954
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  955
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa163_R_ilmn (Illumina)

<400>  955
ggagttcaga cgtgtgctct tccgatctat tcccaagtgg gctttctt                    48


<210>  956
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa164_R_ilmn (Illumina)

<400>  956
ggagttcaga cgtgtgctct tccgatcttt tcctttccca acatcctg                    48


<210>  957
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa165_R_ilmn (Illumina)

<400>  957
ggagttcaga cgtgtgctct tccgatctca accagggttg ttcctttg                    48


<210>  958
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa166_R_ilmn (Illumina)

<400>  958
ggagttcaga cgtgtgctct tccgatctga aggcacagtt accggaga                    48


<210>  959
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa167_R_ilmn (Illumina)

<400>  959
ggagttcaga cgtgtgctct tccgatctaa tactacatgc cggaggacc                   49


<210>  960
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa168_R_ilmn (Illumina)

<400>  960
ggagttcaga cgtgtgctct tccgatctcc tgtccacagc tcactaggt                   49


<210>  961
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa169_R_ilmn (Illumina)

<400>  961
ggagttcaga cgtgtgctct tccgatctgt cctggcgagg agaccta                     47


<210>  962
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa170_R_ilmn (Illumina)

<400>  962
ggagttcaga cgtgtgctct tccgatctcg tgcttacctg tctgtgga                    48


<210>  963
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa171_R_ilmn (Illumina)

<400>  963
ggagttcaga cgtgtgctct tccgatctga tggagagaga ccagcgtc                    48


<210>  964
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa172_R_ilmn (Illumina)

<400>  964
ggagttcaga cgtgtgctct tccgatctgt ttctggctca gttcctgc                    48


<210>  965
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa173_R_ilmn (Illumina)

<400>  965
ggagttcaga cgtgtgctct tccgatctag caatgggcct actaagca                    48


<210>  966
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa174_R_ilmn (Illumina)

<400>  966
ggagttcaga cgtgtgctct tccgatctgg cacccagagt gagtgagt                    48


<210>  967
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa175_R_ilmn (Illumina)

<400>  967
ggagttcaga cgtgtgctct tccgatctag cacctttcac actcaccc                    48


<210>  968
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa176_R_ilmn (Illumina)

<400>  968
ggagttcaga cgtgtgctct tccgatcttt ggcataaacc actgatgc                    48


<210>  969
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa177_R_ilmn (Illumina)

<400>  969
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  970
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa178_R_ilmn (Illumina)

<400>  970
ggagttcaga cgtgtgctct tccgatctgc atttaccagg agcaggaa                    48


<210>  971
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa179_R_ilmn (Illumina)

<400>  971
ggagttcaga cgtgtgctct tccgatctta atgtgacggc aatggaga                    48


<210>  972
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa180_R_ilmn (Illumina)

<400>  972
ggagttcaga cgtgtgctct tccgatctac aggcaggacg ttgactct                    48


<210>  973
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa181_R_ilmn (Illumina)

<400>  973
ggagttcaga cgtgtgctct tccgatctag cacctttcac actcaccc                    48


<210>  974
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa182_R_ilmn (Illumina)

<400>  974
ggagttcaga cgtgtgctct tccgatctag ggctcacctt gacaatga                    48


<210>  975
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa183_R_ilmn (Illumina)

<400>  975
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  976
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa184_R_ilmn (Illumina)

<400>  976
ggagttcaga cgtgtgctct tccgatctgc tgagcaggtg tagacgc                     47


<210>  977
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa185_R_ilmn (Illumina)

<400>  977
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  978
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa186_R_ilmn (Illumina)

<400>  978
ggagttcaga cgtgtgctct tccgatctct gtctccagcc tctggcta                    48


<210>  979
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa187_R_ilmn (Illumina)

<400>  979
ggagttcaga cgtgtgctct tccgatctgc atttaccagg agcaggaa                    48


<210>  980
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa188_R_ilmn (Illumina)

<400>  980
ggagttcaga cgtgtgctct tccgatctga aggcacagtt accggaga                    48


<210>  981
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa189_R_ilmn (Illumina)

<400>  981
ggagttcaga cgtgtgctct tccgatctat ggattcagct cagatggg                    48


<210>  982
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa190_R_ilmn (Illumina)

<400>  982
ggagttcaga cgtgtgctct tccgatctga atcaggcctg ggtgataa                    48


<210>  983
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa191_R_ilmn (Illumina)

<400>  983
ggagttcaga cgtgtgctct tccgatctga aggcacagtt accggaga                    48


<210>  984
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa192_R_ilmn (Illumina)

<400>  984
ggagttcaga cgtgtgctct tccgatctcc actctgagag agcatccc                    48


<210>  985
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa193_R_ilmn (Illumina)

<400>  985
ggagttcaga cgtgtgctct tccgatctcg gaatcagaat cggacact                    48


<210>  986
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa194_R_ilmn (Illumina)

<400>  986
ggagttcaga cgtgtgctct tccgatctgc atttaccagg agcaggaa                    48


<210>  987
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa195_R_ilmn (Illumina)

<400>  987
ggagttcaga cgtgtgctct tccgatctcc atgaaagcta caaccagtga                  50


<210>  988
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa196_R_ilmn (Illumina)

<400>  988
ggagttcaga cgtgtgctct tccgatctta atgtgacggc aatggaga                    48


<210>  989
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa197_R_ilmn (Illumina)

<400>  989
ggagttcaga cgtgtgctct tccgatctga tggagagaga ccagcgtc                    48


<210>  990
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa198_R_ilmn (Illumina)

<400>  990
ggagttcaga cgtgtgctct tccgatctgc aacagagagg acagaccc                    48


<210>  991
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa199_R_ilmn (Illumina)

<400>  991
ggagttcaga cgtgtgctct tccgatctgc atcaccctag gcagtca                     47


<210>  992
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa200_R_ilmn (Illumina)

<400>  992
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  993
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa201_R_ilmn (Illumina)

<400>  993
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  994
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa202_R_ilmn (Illumina)

<400>  994
ggagttcaga cgtgtgctct tccgatctga gtgggtacga tgcattcc                    48


<210>  995
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa203_R_ilmn (Illumina)

<400>  995
ggagttcaga cgtgtgctct tccgatctgg gcaattaaag cggttaca                    48


<210>  996
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa204_R_ilmn (Illumina)

<400>  996
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  997
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa205_R_ilmn (Illumina)

<400>  997
ggagttcaga cgtgtgctct tccgatctga atcaggcctg ggtgataa                    48


<210>  998
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa206_R_ilmn (Illumina)

<400>  998
ggagttcaga cgtgtgctct tccgatctga aggcacagtt accggaga                    48


<210>  999
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa207_R_ilmn (Illumina)

<400>  999
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  1000
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa208_R_ilmn (Illumina)

<400>  1000
ggagttcaga cgtgtgctct tccgatctcc ctcccaagac caggttag                    48


<210>  1001
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa209_R_ilmn (Illumina)

<400>  1001
ggagttcaga cgtgtgctct tccgatctgg cacccagagt gagtgagt                    48


<210>  1002
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa210_R_ilmn (Illumina)

<400>  1002
ggagttcaga cgtgtgctct tccgatctgc aacagagagg acagaccc                    48


<210>  1003
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa211_R_ilmn (Illumina)

<400>  1003
ggagttcaga cgtgtgctct tccgatctcg gaatcagaat cggacact                    48


<210>  1004
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa212_R_ilmn (Illumina)

<400>  1004
ggagttcaga cgtgtgctct tccgatctag ggctcacctt gacaatga                    48


<210>  1005
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa213_R_ilmn (Illumina)

<400>  1005
ggagttcaga cgtgtgctct tccgatctga ggagacctag aggccgtg                    48


<210>  1006
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa214_R_ilmn (Illumina)

<400>  1006
ggagttcaga cgtgtgctct tccgatctat ggattcagct cagatggg                    48


<210>  1007
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa215_R_ilmn (Illumina)

<400>  1007
ggagttcaga cgtgtgctct tccgatctag cacctttcac actcaccc                    48


<210>  1008
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa216_R_ilmn (Illumina)

<400>  1008
ggagttcaga cgtgtgctct tccgatctgc aacagagagg acagaccc                    48


<210>  1009
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa217_R_ilmn (Illumina)

<400>  1009
ggagttcaga cgtgtgctct tccgatctga atcaggcctg ggtgataa                    48


<210>  1010
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa218_R_ilmn (Illumina)

<400>  1010
ggagttcaga cgtgtgctct tccgatctcg gaatcagaat cggacact                    48


<210>  1011
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa219_R_ilmn (Illumina)

<400>  1011
ggagttcaga cgtgtgctct tccgatcttt cattctcttc ggaggaaca                   49


<210>  1012
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa220_R_ilmn (Illumina)

<400>  1012
ggagttcaga cgtgtgctct tccgatctgc ggtggatctt gagatagc                    48


<210>  1013
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa221_R_ilmn (Illumina)

<400>  1013
ggagttcaga cgtgtgctct tccgatctga tggagagaga ccagcgtc                    48


<210>  1014
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa222_R_ilmn (Illumina)

<400>  1014
ggagttcaga cgtgtgctct tccgatctgg cacccagagt gagtgagt                    48


<210>  1015
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa223_R_ilmn (Illumina)

<400>  1015
ggagttcaga cgtgtgctct tccgatctgc aacagagagg acagaccc                    48


<210>  1016
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa224_R_ilmn (Illumina)

<400>  1016
ggagttcaga cgtgtgctct tccgatctct ccagtcctgc ctatcagc                    48


<210>  1017
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa33F

<400>  1017
accgagcgtt tcctcacgtc acagtatgtc tctggcgagt tccccgcgcc agcggggata       60

aaccgtacta aaaatgtact gacctcctat taatgcc                                97


<210>  1018
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa36F

<400>  1018
accgcctcat tcgctgccaa cctagccagc ccagaagagt tccccgcgcc agcggggata       60

aaccgtcgac agccacagac ttgtctggcg gagtttc                                97


<210>  1019
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa37F

<400>  1019
accgtctgtg gctgtcgaca tgctaagtga gggcctgagt tccccgcgcc agcggggata       60

aaccgtagtc tcaagtttgt tcaaagctgg actcctc                                97


<210>  1020
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa38F

<400>  1020
accgttggct gttatgagga cttcacagct ggtgtcgagt tccccgcgcc agcggggata       60

aaccgggagg aaggactcct ccactggaga actgata                                97


<210>  1021
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa39F

<400>  1021
accgaggtaa tgcgtcggcc cgggactaca tctcccgagt tccccgcgcc agcggggata       60

aaccgacggc aactcggtta agtcttcccc caccgcc                                97


<210>  1022
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa40F

<400>  1022
accgatgcgg tagtcgctgc agctagctgc ccacctgagt tccccgcgcc agcggggata       60

aaccggggag gcggggtaag ggaagtaggt ggaagat                                97


<210>  1023
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa42F

<400>  1023
accggcagga ggaggtggag agagagtggg ggaaaagagt tccccgcgcc agcggggata       60

aaccgatgaa aaggcagtca ggtcttcagt agccaaa                                97


<210>  1024
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa43F

<400>  1024
accgatgagt ctaggttaca ttcagtgcaa aaaaccgagt tccccgcgcc agcggggata       60

aaccggtaag tttttaaaat atatatctac catgtat                                97


<210>  1025
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa44F

<400>  1025
accgctttcc ttggagccaa atttaaaacc tctgccgagt tccccgcgcc agcggggata       60

aaccgctagg gcctcggtga tggaaatcca cttgtgc                                97


<210>  1026
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa45F

<400>  1026
accgcatgac ggacaagtac aggctgcacc tgtcaggagt tccccgcgcc agcggggata       60

aaccgaccaa tccattgccc acaatgccag ttaagaa                                97


<210>  1027
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa46F

<400>  1027
accgacaagt tttgggtctc agcgcaggcc tcagttgagt tccccgcgcc agcggggata       60

aaccgaggtc tgtccagatg ctaagaccag gtacttc                                97


<210>  1028
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa47F

<400>  1028
accggtaatg tgtggggagc gggcgtcgga aggaccgagt tccccgcgcc agcggggata       60

aaccgcacga aggggttggg ggatgctggg ggtccgg                                97


<210>  1029
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa48F

<400>  1029
accgcggcgg ctgagggtga cccagaaccg ggtcccgagt tccccgcgcc agcggggata       60

aaccgaaggc cagttgtatg gaccgtgtgg tggtggt                                97


<210>  1030
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa49F

<400>  1030
accgtatatc tgcaaattta ataaatcaag agggaagagt tccccgcgcc agcggggata       60

aaccgacaaa tcacaaactg gtgtgaatag agccagc                                97


<210>  1031
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa51F

<400>  1031
accgaagact aagaggtagt ttctgaactt ctccccgagt tccccgcgcc agcggggata       60

aaccgctgtt ctattttcca gcaagaggct cccgagc                                97


<210>  1032
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa52F

<400>  1032
accggactga agaccaagca acctggaaag aagtcggagt tccccgcgcc agcggggata       60

aaccgtgtct gcaggagagc aaaacaaact tagccgt                                97


<210>  1033
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa53F

<400>  1033
accgttggcc tctctttgga tccaataggc atttttgagt tccccgcgcc agcggggata       60

aaccgcaggt attgacaaat tttatataac tttataa                                97


<210>  1034
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa56F

<400>  1034
accgaaacta caacacctag tacccttgga agtaccgagt tccccgcgcc agcggggata       60

aaccgttccc tgggtaggta actctggggt agcagta                                97


<210>  1035
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa58F

<400>  1035
accgggatgg catgggagac aaggtactcc tccagggagt tccccgcgcc agcggggata       60

aaccggcctt aacagaaatc tcggattctc tcctggg                                97


<210>  1036
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa59F

<400>  1036
accgattgga attatcttct agctcttgtc gaagatgagt tccccgcgcc agcggggata       60

aaccgaaggt atcaagactg tgacttttaa ttgtagt                                97


<210>  1037
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa60F

<400>  1037
accgatgatt ggaattatct tctagctctt gtcgaagagt tccccgcgcc agcggggata       60

aaccggtatc aagactgtga cttttaattg tagttta                                97


<210>  1038
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa62F

<400>  1038
accgggaaca gattttgtgc aaaactctgc agaaacgagt tccccgcgcc agcggggata       60

aaccgcagtt ccaaggtcag taaattactg aaaggta                                97


<210>  1039
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa63F

<400>  1039
accggaatcc agcttcttcc aatttcttca catcgtgagt tccccgcgcc agcggggata       60

aaccggagct aataaatatt aagggaatta gtgaagc                                97


<210>  1040
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa67F

<400>  1040
accgccagag gcccggcacc cccgcacagg cgcctcgagt tccccgcgcc agcggggata       60

aaccgaagga gcaattcctc ttctgcccgc ttggctg                                97


<210>  1041
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa68F

<400>  1041
accggaaggg tcgctctttg cagcttcttt gaattcgagt tccccgcgcc agcggggata       60

aaccgagctg atgtcaatgc tatggactgc acaaaag                                97


<210>  1042
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa69F

<400>  1042
accgaacaaa atcctctatg tctgtagaca actcttgagt tccccgcgcc agcggggata       60

aaccgcaagg taagccagcg actgctagat ttttttt                                97


<210>  1043
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa72F

<400>  1043
accgccagtg gcactggggg gtgccgcctc ggggcagagt tccccgcgcc agcggggata       60

aaccggccag gcccaggcga ctggcggcca ggtgtcc                                97


<210>  1044
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa74F

<400>  1044
accgggctac agaaaccgtg ccaaaagact tctacagagt tccccgcgcc agcggggata       60

aaccgttcag gagagttatt ttcctttttt gcaaaat                                97


<210>  1045
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa77F

<400>  1045
accggatttc ctaaaggaat ttaacaacaa gaccatgagt tccccgcgcc agcggggata       60

aaccggttcc tctgtctgat ggacttattc aatgttt                                97


<210>  1046
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa78F

<400>  1046
accgacggtg gaaacgttct ctactacgaa gtgatggagt tccccgcgcc agcggggata       60

aaccgaaatc agtaacatgg aagtctcaaa tatttca                                97


<210>  1047
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa82F

<400>  1047
accgaattat gagatatgga aacagacgca tttttagagt tccccgcgcc agcggggata       60

aaccgtgcca ccaggtaaat atcaatttat ttctttt                                97


<210>  1048
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa84F

<400>  1048
accgtctttt taactctctc ctgtagaatc ttacatgagt tccccgcgcc agcggggata       60

aaccgaagat atacaaaaag aaacagttta ttgctta                                97


<210>  1049
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa87F

<400>  1049
accggcttct ctgattttgg taggctagaa atacgtgagt tccccgcgcc agcggggata       60

aaccgaagag cagcatcttg aatctcatac agactgc                                97


<210>  1050
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa88F

<400>  1050
accgatgctg ctcttcatct ctcttattta ccactggagt tccccgcgcc agcggggata       60

aaccgcaggc aatatctgga acttctccag tggcttc                                97


<210>  1051
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa89F

<400>  1051
accgtttttc caaatcctgt taaagtataa aacagagagt tccccgcgcc agcggggata       60

aaccgaccac attggaaagt caatgccaaa tgtccta                                97


<210>  1052
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa92F

<400>  1052
accggcagca gtcagtgggc agtggcccct tgcagcgagt tccccgcgcc agcggggata       60

aaccgcactc tgactgcctg gtatgtgcct ctgcttt                                97


<210>  1053
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa94F

<400>  1053
accgcgtgga tgctggcctc cctgtggccc acgcacgagt tccccgcgcc agcggggata       60

aaccgtcaag gagcatggaa tcccggcccc tcaggag                                97


<210>  1054
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa96F

<400>  1054
accgcaaaca ccgcatctgg gagaggaaag cagaaggagt tccccgcgcc agcggggata       60

aaccgccctg ttgatgcagg acactcgccg caggctc                                97


<210>  1055
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa97F

<400>  1055
accgccctgc ccactactct cttaatgctg acaacagagt tccccgcgcc agcggggata       60

aaccgcagag gtgggagcag tgcccattgc tggaagc                                97


<210>  1056
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa98F

<400>  1056
accgtgcttc cagcaatggg cactgctccc acctctgagt tccccgcgcc agcggggata       60

aaccgacgag gatgtccatc acataatcca aatggcc                                97


<210>  1057
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa99F

<400>  1057
accgactgct cagggctatc ctctcagagt gacattgagt tccccgcgcc agcggggata       60

aaccgctgct tcaccttaaa taacaaaaac agaggtt                                97


<210>  1058
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa100F

<400>  1058
accggacaaa gttggttctt cagaatcatt ctgtgagagt tccccgcgcc agcggggata       60

aaccgttcta gaaatgaaac atgttctaat aatacag                                97


<210>  1059
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa101F

<400>  1059
accgagctag ttaaggacaa agttggttct tcagaagagt tccccgcgcc agcggggata       60

aaccgaaaca tgttctaata atacagtaat ctctcag                                97


<210>  1060
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa103F

<400>  1060
accgaaaacc caatagagta ggttctttga tcttttgagt tccccgcgcc agcggggata       60

aaccggaatc tttggacaaa gtgaaaaacc tttttga                                97


<210>  1061
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa104F

<400>  1061
accgattcct ttgcaatttt aacttttttc ccgctagagt tccccgcgcc agcggggata       60

aaccgagcaa ggtactagtg aaatcaccag ttttagc                                97


<210>  1062
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa105F

<400>  1062
accgttttga gattttcagt ttgtctacat aaattagagt tccccgcgcc agcggggata       60

aaccgaaaat gtagaaaaag aaacagcaaa aagtcct                                97


<210>  1063
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa106F

<400>  1063
accgtctgac tcacagaagt ttttctacta caacttgagt tccccgcgcc agcggggata       60

aaccggaata tttgatggtc aaccagaaag aataaat                                97


<210>  1064
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa107F

<400>  1064
accgcagatg aatttaccac attatatgaa aagcctgagt tccccgcgcc agcggggata       60

aaccgtttcc attttagaaa gttccttaca caaagtt                                97


<210>  1065
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa108F

<400>  1065
accgtttcag ttttaccaat ttccattttt acgtttgagt tccccgcgcc agcggggata       60

aaccgtttgt tctacttact ccaaagattc agaaaac                                97


<210>  1066
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa109F

<400>  1066
accgtgtggc atgacttggc agtttagaat ctgtcagagt tccccgcgcc agcggggata       60

aaccggtttt gtcaaattca agaattggaa aaagaag                                97


<210>  1067
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa112F

<400>  1067
accgttatgc aattcttctg gtttctgatc aaagaagagt tccccgcgcc agcggggata       60

aaccgaaaga acaaaatgga cattctaagt tatgagg                                97


<210>  1068
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa120F

<400>  1068
accggaatga tttccacaga ggtgaggcca ggggccgagt tccccgcgcc agcggggata       60

aaccgccatg gacttctatg atccagcaag gtaggtt                                97


<210>  1069
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa122F

<400>  1069
accgaagaat cttctctgaa cctacaagag aggaaagagt tccccgcgcc agcggggata       60

aaccgagatg atgaggtgag ttggcagcag gtctttg                                97


<210>  1070
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa123F

<400>  1070
accgtgacgg gctattaccg ggtgaactac gacgaagagt tccccgcgcc agcggggata       60

aaccgtgctg aagagatcgt tctgggctgt ggagagg                                97


<210>  1071
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa124F

<400>  1071
accgtctaag tcatccaaag catgaatcag ggaggagagt tccccgcgcc agcggggata       60

aaccgagcta atcctcaagt cggcgtggct tttcctc                                97


<210>  1072
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa126F

<400>  1072
accgtcttag accccagcca cagggatatt tccctggagt tccccgcgcc agcggggata       60

aaccgttcct tcgtcatcct tgtaatccat cagggtc                                97


<210>  1073
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa128F

<400>  1073
accggtaaat atgagggaaa tgtctttcta tgaagagagt tccccgcgcc agcggggata       60

aaccgctgtg ttctcatgtc aaaaacatgg aactttc                                97


<210>  1074
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa33R

<400>  1074
actcggcatt aataggaggt cagtacattt ttagtacggt ttatccccgc tggcgcgggg       60

aactcgccag agacatactg tgacgtgagg aaacgct                                97


<210>  1075
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa36R

<400>  1075
actcgaaact ccgccagaca agtctgtggc tgtcgacggt ttatccccgc tggcgcgggg       60

aactcttctg ggctggctag gttggcagcg aatgagg                                97


<210>  1076
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa37R

<400>  1076
actcgaggag tccagctttg aacaaacttg agactacggt ttatccccgc tggcgcgggg       60

aactcaggcc ctcacttagc atgtcgacag ccacaga                                97


<210>  1077
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa38R

<400>  1077
actctatcag ttctccagtg gaggagtcct tcctcccggt ttatccccgc tggcgcgggg       60

aactcgacac cagctgtgaa gtcctcataa cagccaa                                97


<210>  1078
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa39R

<400>  1078
actcggcggt gggggaagac ttaaccgagt tgccgtcggt ttatccccgc tggcgcgggg       60

aactcgggag atgtagtccc gggccgacgc attacct                                97


<210>  1079
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa40R

<400>  1079
actcatcttc cacctacttc ccttaccccg cctccccggt ttatccccgc tggcgcgggg       60

aactcaggtg ggcagctagc tgcagcgact accgcat                                97


<210>  1080
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa42R

<400>  1080
actctttggc tactgaagac ctgactgcct tttcatcggt ttatccccgc tggcgcgggg       60

aactcttttc ccccactctc tctccacctc ctcctgc                                97


<210>  1081
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa43R

<400>  1081
actcatacat ggtagatata tattttaaaa acttaccggt ttatccccgc tggcgcgggg       60

aactcggttt tttgcactga atgtaaccta gactcat                                97


<210>  1082
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa44R

<400>  1082
actcgcacaa gtggatttcc atcaccgagg ccctagcggt ttatccccgc tggcgcgggg       60

aactcggcag aggttttaaa tttggctcca aggaaag                                97


<210>  1083
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa45R

<400>  1083
actcttctta actggcattg tgggcaatgg attggtcggt ttatccccgc tggcgcgggg       60

aactcctgac aggtgcagcc tgtacttgtc cgtcatg                                97


<210>  1084
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa46R

<400>  1084
actcgaagta cctggtctta gcatctggac agacctcggt ttatccccgc tggcgcgggg       60

aactcaactg aggcctgcgc tgagacccaa aacttgt                                97


<210>  1085
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa47R

<400>  1085
actcccggac ccccagcatc ccccaacccc ttcgtgcggt ttatccccgc tggcgcgggg       60

aactcggtcc ttccgacgcc cgctccccac acattac                                97


<210>  1086
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa48R

<400>  1086
actcaccacc accacacggt ccatacaact ggccttcggt ttatccccgc tggcgcgggg       60

aactcgggac ccggttctgg gtcaccctca gccgccg                                97


<210>  1087
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa49R

<400>  1087
actcgctggc tctattcaca ccagtttgtg atttgtcggt ttatccccgc tggcgcgggg       60

aactcttccc tcttgattta ttaaatttgc agatata                                97


<210>  1088
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa51R

<400>  1088
actcgctcgg gagcctcttg ctggaaaata gaacagcggt ttatccccgc tggcgcgggg       60

aactcgggga gaagttcaga aactacctct tagtctt                                97


<210>  1089
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa52R

<400>  1089
actcacggct aagtttgttt tgctctcctg cagacacggt ttatccccgc tggcgcgggg       60

aactccgact tctttccagg ttgcttggtc ttcagtc                                97


<210>  1090
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa53R

<400>  1090
actcttataa agttatataa aatttgtcaa tacctgcggt ttatccccgc tggcgcgggg       60

aactcaaaaa tgcctattgg atccaaagag aggccaa                                97


<210>  1091
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa56R

<400>  1091
actctactgc taccccagag ttacctaccc agggaacggt ttatccccgc tggcgcgggg       60

aactcggtac ttccaagggt actaggtgtt gtagttt                                97


<210>  1092
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa58R

<400>  1092
actccccagg agagaatccg agatttctgt taaggccggt ttatccccgc tggcgcgggg       60

aactccctgg aggagtacct tgtctcccat gccatcc                                97


<210>  1093
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa59R

<400>  1093
actcactaca attaaaagtc acagtcttga taccttcggt ttatccccgc tggcgcgggg       60

aactcatctt cgacaagagc tagaagataa ttccaat                                97


<210>  1094
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa60R

<400>  1094
actctaaact acaattaaaa gtcacagtct tgataccggt ttatccccgc tggcgcgggg       60

aactcttcga caagagctag aagataattc caatcat                                97


<210>  1095
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa62R

<400>  1095
actctacctt tcagtaattt actgaccttg gaactgcggt ttatccccgc tggcgcgggg       60

aactcgtttc tgcagagttt tgcacaaaat ctgttcc                                97


<210>  1096
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa63R

<400>  1096
actcgcttca ctaattccct taatatttat tagctccggt ttatccccgc tggcgcgggg       60

aactcacgat gtgaagaaat tggaagaagc tggattc                                97


<210>  1097
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa67R

<400>  1097
actccagcca agcgggcaga agaggaattg ctccttcggt ttatccccgc tggcgcgggg       60

aactcgaggc gcctgtgcgg gggtgccggg cctctgg                                97


<210>  1098
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa68R

<400>  1098
actccttttg tgcagtccat agcattgaca tcagctcggt ttatccccgc tggcgcgggg       60

aactcgaatt caaagaagct gcaaagagcg acccttc                                97


<210>  1099
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa69R

<400>  1099
actcaaaaaa aatctagcag tcgctggctt accttgcggt ttatccccgc tggcgcgggg       60

aactcaagag ttgtctacag acatagagga ttttgtt                                97


<210>  1100
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa72R

<400>  1100
actcggacac ctggccgcca gtcgcctggg cctggccggt ttatccccgc tggcgcgggg       60

aactctgccc cgaggcggca ccccccagtg ccactgg                                97


<210>  1101
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa74R

<400>  1101
actcattttg caaaaaagga aaataactct cctgaacggt ttatccccgc tggcgcgggg       60

aactctgtag aagtcttttg gcacggtttc tgtagcc                                97


<210>  1102
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa77R

<400>  1102
actcaaacat tgaataagtc catcagacag aggaaccggt ttatccccgc tggcgcgggg       60

aactcatggt cttgttgtta aattccttta ggaaatc                                97


<210>  1103
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa78R

<400>  1103
actctgaaat atttgagact tccatgttac tgatttcggt ttatccccgc tggcgcgggg       60

aactccatca cttcgtagta gagaacgttt ccaccgt                                97


<210>  1104
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa82R

<400>  1104
actcaaaaga aataaattga tatttacctg gtggcacggt ttatccccgc tggcgcgggg       60

aactctaaaa atgcgtctgt ttccatatct cataatt                                97


<210>  1105
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa84R

<400>  1105
actctaagca ataaactgtt tctttttgta tatcttcggt ttatccccgc tggcgcgggg       60

aactcatgta agattctaca ggagagagtt aaaaaga                                97


<210>  1106
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa87R

<400>  1106
actcgcagtc tgtatgagat tcaagatgct gctcttcggt ttatccccgc tggcgcgggg       60

aactcacgta tttctagcct accaaaatca gagaagc                                97


<210>  1107
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa88R

<400>  1107
actcgaagcc actggagaag ttccagatat tgcctgcggt ttatccccgc tggcgcgggg       60

aactccagtg gtaaataaga gagatgaaga gcagcat                                97


<210>  1108
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa89R

<400>  1108
actctaggac atttggcatt gactttccaa tgtggtcggt ttatccccgc tggcgcgggg       60

aactctctgt tttatacttt aacaggattt ggaaaaa                                97


<210>  1109
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa92R

<400>  1109
actcaaagca gaggcacata ccaggcagtc agagtgcggt ttatccccgc tggcgcgggg       60

aactcgctgc aaggggccac tgcccactga ctgctgc                                97


<210>  1110
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa94R

<400>  1110
actcctcctg aggggccggg attccatgct ccttgacggt ttatccccgc tggcgcgggg       60

aactcgtgcg tgggccacag ggaggccagc atccacg                                97


<210>  1111
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa96R

<400>  1111
actcgagcct gcggcgagtg tcctgcatca acagggcggt ttatccccgc tggcgcgggg       60

aactccttct gctttcctct cccagatgcg gtgtttg                                97


<210>  1112
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa97R

<400>  1112
actcgcttcc agcaatgggc actgctccca cctctgcggt ttatccccgc tggcgcgggg       60

aactctgttg tcagcattaa gagagtagtg ggcaggg                                97


<210>  1113
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa98R

<400>  1113
actcggccat ttggattatg tgatggacat cctcgtcggt ttatccccgc tggcgcgggg       60

aactcagagg tgggagcagt gcccattgct ggaagca                                97


<210>  1114
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa99R

<400>  1114
actcaacctc tgtttttgtt atttaaggtg aagcagcggt ttatccccgc tggcgcgggg       60

aactcaatgt cactctgaga ggatagccct gagcagt                                97


<210>  1115
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa100R

<400>  1115
actcctgtat tattagaaca tgtttcattt ctagaacggt ttatccccgc tggcgcgggg       60

aactctcaca gaatgattct gaagaaccaa ctttgtc                                97


<210>  1116
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa101R

<400>  1116
actcctgaga gattactgta ttattagaac atgtttcggt ttatccccgc tggcgcgggg       60

aactcttctg aagaaccaac tttgtcctta actagct                                97


<210>  1117
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa103R

<400>  1117
actctcaaaa aggtttttca ctttgtccaa agattccggt ttatccccgc tggcgcgggg       60

aactcaaaag atcaaagaac ctactctatt gggtttt                                97


<210>  1118
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa104R

<400>  1118
actcgctaaa actggtgatt tcactagtac cttgctcggt ttatccccgc tggcgcgggg       60

aactctagcg ggaaaaaagt taaaattgca aaggaat                                97


<210>  1119
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa105R

<400>  1119
actcaggact ttttgctgtt tctttttcta cattttcggt ttatccccgc tggcgcgggg       60

aactctaatt tatgtagaca aactgaaaat ctcaaaa                                97


<210>  1120
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa106R

<400>  1120
actcatttat tctttctggt tgaccatcaa atattccggt ttatccccgc tggcgcgggg       60

aactcaagtt gtagtagaaa aacttctgtg agtcaga                                97


<210>  1121
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa107R

<400>  1121
actcaacttt gtgtaaggaa ctttctaaaa tggaaacggt ttatccccgc tggcgcgggg       60

aactcaggct tttcatataa tgtggtaaat tcatctg                                97


<210>  1122
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa108R

<400>  1122
actcgttttc tgaatctttg gagtaagtag aacaaacggt ttatccccgc tggcgcgggg       60

aactcaaacg taaaaatgga aattggtaaa actgaaa                                97


<210>  1123
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa109R

<400>  1123
actccttctt tttccaattc ttgaatttga caaaaccggt ttatccccgc tggcgcgggg       60

aactctgaca gattctaaac tgccaagtca tgccaca                                97


<210>  1124
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa112R

<400>  1124
actccctcat aacttagaat gtccattttg ttctttcggt ttatccccgc tggcgcgggg       60

aactcttctt tgatcagaaa ccagaagaat tgcataa                                97


<210>  1125
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa120R

<400>  1125
actcaaccta ccttgctgga tcatagaagt ccatggcggt ttatccccgc tggcgcgggg       60

aactcggccc ctggcctcac ctctgtggaa atcattc                                97


<210>  1126
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa122R

<400>  1126
actccaaaga cctgctgcca actcacctca tcatctcggt ttatccccgc tggcgcgggg       60

aactctttcc tctcttgtag gttcagagaa gattctt                                97


<210>  1127
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa123R

<400>  1127
actccctctc cacagcccag aacgatctct tcagcacggt ttatccccgc tggcgcgggg       60

aactcttcgt cgtagttcac ccggtaatag cccgtca                                97


<210>  1128
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa124R

<400>  1128
actcgaggaa aagccacgcc gacttgagga ttagctcggt ttatccccgc tggcgcgggg       60

aactctcctc cctgattcat gctttggatg acttaga                                97


<210>  1129
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa126R

<400>  1129
actcgaccct gatggattac aaggatgacg aaggaacggt ttatccccgc tggcgcgggg       60

aactccaggg aaatatccct gtggctgggg tctaaga                                97


<210>  1130
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa128R

<400>  1130
actcgaaagt tccatgtttt tgacatgaga acacagcggt ttatccccgc tggcgcgggg       60

aactctcttc atagaaagac atttccctca tatttac                                97


<210>  1131
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa33F_ilmn (Illumina)

<400>  1131
cactctttcc ctacacgacg ctcttccgat ctccagtcat gaacgtctcc g                51


<210>  1132
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa36F_ilmn (Illumina)

<400>  1132
cactctttcc ctacacgacg ctcttccgat ctgaagagcc ctgccgagag                  50


<210>  1133
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa37F_ilmn (Illumina)

<400>  1133
cactctttcc ctacacgacg ctcttccgat ctctaggttg gcagcgaatg ag               52


<210>  1134
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa38F_ilmn (Illumina)

<400>  1134
cactctttcc ctacacgacg ctcttccgat ctcagcctat gagcttcctg gt               52


<210>  1135
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa39F_ilmn (Illumina)

<400>  1135
cactctttcc ctacacgacg ctcttccgat ctaatagtcc agctgcgatg gt               52


<210>  1136
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa40F_ilmn (Illumina)

<400>  1136
cactctttcc ctacacgacg ctcttccgat ctcgcaagtt tccttctctg ga               52


<210>  1137
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa42F_ilmn (Illumina)

<400>  1137
cactctttcc ctacacgacg ctcttccgat ctcttcagca ctgcagccac                  50


<210>  1138
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa43F_ilmn (Illumina)

<400>  1138
cactctttcc ctacacgacg ctcttccgat ctccactgtt tcatgtggca tc               52


<210>  1139
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa44F_ilmn (Illumina)

<400>  1139
cactctttcc ctacacgacg ctcttccgat ctgatgaatg tccacctcgc tt               52


<210>  1140
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa45F_ilmn (Illumina)

<400>  1140
cactctttcc ctacacgacg ctcttccgat cttcccaaag taccagtttg cc               52


<210>  1141
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa46F_ilmn (Illumina)

<400>  1141
cactctttcc ctacacgacg ctcttccgat cttttggaca cacgaaggca ta               52


<210>  1142
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa47F_ilmn (Illumina)

<400>  1142
cactctttcc ctacacgacg ctcttccgat ctctcagcca tctccttctc gt               52


<210>  1143
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa48F_ilmn (Illumina)

<400>  1143
cactctttcc ctacacgacg ctcttccgat ctagtgccgc tatggggacc t                51


<210>  1144
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa49F_ilmn (Illumina)

<400>  1144
cactctttcc ctacacgacg ctcttccgat ctcaccttta ttcctttgtc taacaatct        59


<210>  1145
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa51F_ilmn (Illumina)

<400>  1145
cactctttcc ctacacgacg ctcttccgat ctagactctt gggatgacgc ac               52


<210>  1146
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa52F_ilmn (Illumina)

<400>  1146
cactctttcc ctacacgacg ctcttccgat ctcaagctct ggtaggcagc tc               52


<210>  1147
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa53F_ilmn (Illumina)

<400>  1147
cactctttcc ctacacgacg ctcttccgat ctaatgcatc cctgtgtaag tgc              53


<210>  1148
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa56F_ilmn (Illumina)

<400>  1148
cactctttcc ctacacgacg ctcttccgat ctccatgttg agacacaggg tg               52


<210>  1149
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa58F_ilmn (Illumina)

<400>  1149
cactctttcc ctacacgacg ctcttccgat ctaggtctct ctggtgctgg aa               52


<210>  1150
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa59F_ilmn (Illumina)

<400>  1150
cactctttcc ctacacgacg ctcttccgat cttgaggcac tgaagatgga ga               52


<210>  1151
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa60F_ilmn (Illumina)

<400>  1151
cactctttcc ctacacgacg ctcttccgat cttgaggcac tgaagatgga ga               52


<210>  1152
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa62F_ilmn (Illumina)

<400>  1152
cactctttcc ctacacgacg ctcttccgat cttttgccct gaattcctta catac            55


<210>  1153
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa63F_ilmn (Illumina)

<400>  1153
cactctttcc ctacacgacg ctcttccgat ctcttcattt gcagcagtgt gg               52


<210>  1154
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa67F_ilmn (Illumina)

<400>  1154
cactctttcc ctacacgacg ctcttccgat ctcccaactc acctcatcac ct               52


<210>  1155
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa68F_ilmn (Illumina)

<400>  1155
cactctttcc ctacacgacg ctcttccgat ctaaatgaat gaggatggcc tg               52


<210>  1156
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa69F_ilmn (Illumina)

<400>  1156
cactctttcc ctacacgacg ctcttccgat ctggcttgct ttcagtttgg ag               52


<210>  1157
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa72F_ilmn (Illumina)

<400>  1157
cactctttcc ctacacgacg ctcttccgat ctcctgactt gggtacgtgc tt               52


<210>  1158
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa74F_ilmn (Illumina)

<400>  1158
cactctttcc ctacacgacg ctcttccgat ctcaaggaag gattttcggg tt               52


<210>  1159
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa77F_ilmn (Illumina)

<400>  1159
cactctttcc ctacacgacg ctcttccgat cttcaggtca tgcgtggaca                  50


<210>  1160
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa78F_ilmn (Illumina)

<400>  1160
cactctttcc ctacacgacg ctcttccgat ctcatacgct atgtgacacg gg               52


<210>  1161
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa82F_ilmn (Illumina)

<400>  1161
cactctttcc ctacacgacg ctcttccgat ctgcacaaac aatgaggtgc at               52


<210>  1162
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa84F_ilmn (Illumina)

<400>  1162
cactctttcc ctacacgacg ctcttccgat ctcaattgga atcctaactt tccttg           56


<210>  1163
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa87F_ilmn (Illumina)

<400>  1163
cactctttcc ctacacgacg ctcttccgat cttgcatatt tcttcatgtg acca             54


<210>  1164
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa88F_ilmn (Illumina)

<400>  1164
cactctttcc ctacacgacg ctcttccgat ctctttgcca cgtatttcta gcct             54


<210>  1165
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa89F_ilmn (Illumina)

<400>  1165
cactctttcc ctacacgacg ctcttccgat ctttctatga gaaaggttgt gagaataata       60


<210>  1166
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa92F_ilmn (Illumina)

<400>  1166
cactctttcc ctacacgacg ctcttccgat ctagtgacgc gcactgtctg t                51


<210>  1167
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa94F_ilmn (Illumina)

<400>  1167
cactctttcc ctacacgacg ctcttccgat ctgaccttgg cacccacaag                  50


<210>  1168
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa96F_ilmn (Illumina)

<400>  1168
cactctttcc ctacacgacg ctcttccgat ctccagtgga taatgaatgc aca              53


<210>  1169
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa97F_ilmn (Illumina)

<400>  1169
cactctttcc ctacacgacg ctcttccgat cttagcttgc tttggaggga aa               52


<210>  1170
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa98F_ilmn (Illumina)

<400>  1170
cactctttcc ctacacgacg ctcttccgat ctaagagagt agtgggcagg gc               52


<210>  1171
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa99F_ilmn (Illumina)

<400>  1171
cactctttcc ctacacgacg ctcttccgat ctaatgcaaa ggacaccaca ca               52


<210>  1172
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa100F_ilmn (Illumina)

<400>  1172
cactctttcc ctacacgacg ctcttccgat ctggtttatt gcattcttct gtgaaa           56


<210>  1173
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa101F_ilmn (Illumina)

<400>  1173
cactctttcc ctacacgacg ctcttccgat ctggtttatt gcattcttct gtgaaa           56


<210>  1174
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa103F_ilmn (Illumina)

<400>  1174
cactctttcc ctacacgacg ctcttccgat ctagtgacct tccagggaca ac               52


<210>  1175
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa104F_ilmn (Illumina)

<400>  1175
cactctttcc ctacacgacg ctcttccgat ctagtgacct tccagggaca ac               52


<210>  1176
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa105F_ilmn (Illumina)

<400>  1176
cactctttcc ctacacgacg ctcttccgat cttgtggtgc cacctaagct ct               52


<210>  1177
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa106F_ilmn (Illumina)

<400>  1177
cactctttcc ctacacgacg ctcttccgat ctttcagtca ttgaaaattc agcc             54


<210>  1178
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa107F_ilmn (Illumina)

<400>  1178
cactctttcc ctacacgacg ctcttccgat ctcgaacatt cagaccagct ca               52


<210>  1179
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa108F_ilmn (Illumina)

<400>  1179
cactctttcc ctacacgacg ctcttccgat ctagtgtcac ttgttgagaa cattcat          57


<210>  1180
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa109F_ilmn (Illumina)

<400>  1180
cactctttcc ctacacgacg ctcttccgat cttttgaaac agaagcagta gaaattg          57


<210>  1181
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa112F_ilmn (Illumina)

<400>  1181
cactctttcc ctacacgacg ctcttccgat ctttagtgtc gccaaagagt cattta           56


<210>  1182
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa120F_ilmn (Illumina)

<400>  1182
cactctttcc ctacacgacg ctcttccgat ctcccatcct gaaaccaaga ag               52


<210>  1183
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa122F_ilmn (Illumina)

<400>  1183
cactctttcc ctacacgacg ctcttccgat cttggaattt cttggcaatg tg               52


<210>  1184
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa123F_ilmn (Illumina)

<400>  1184
cactctttcc ctacacgacg ctcttccgat ctcaccgagt ggtctctctg c                51


<210>  1185
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa124F_ilmn (Illumina)

<400>  1185
cactctttcc ctacacgacg ctcttccgat cttccatctt tcttaccagg cag              53


<210>  1186
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa126F_ilmn (Illumina)

<400>  1186
cactctttcc ctacacgacg ctcttccgat ctcaagggtt cttctcaacc ca               52


<210>  1187
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa128F_ilmn (Illumina)

<400>  1187
cactctttcc ctacacgacg ctcttccgat ctcctggaag aaaccttggt ga               52


<210>  1188
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa33R_ilmn (Illumina)

<400>  1188
ggagttcaga cgtgtgctct tccgatctaa ggcccagaat tcagcata                    48


<210>  1189
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa36R_ilmn (Illumina)

<400>  1189
ggagttcaga cgtgtgctct tccgatctac ttaagtgggc accaggag                    48


<210>  1190
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa37R_ilmn (Illumina)

<400>  1190
ggagttcaga cgtgtgctct tccgatctga caaatctcca gctgctcc                    48


<210>  1191
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa38R_ilmn (Illumina)

<400>  1191
ggagttcaga cgtgtgctct tccgatctat agcagtttcc atggtgcc                    48


<210>  1192
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa39R_ilmn (Illumina)

<400>  1192
ggagttcaga cgtgtgctct tccgatctgc gagagtatcg tctgagcc                    48


<210>  1193
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa40R_ilmn (Illumina)

<400>  1193
ggagttcaga cgtgtgctct tccgatcttt ctggaaagct cctcggta                    48


<210>  1194
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa42R_ilmn (Illumina)

<400>  1194
ggagttcaga cgtgtgctct tccgatcttg tccactgaag taggtgcaaa                  50


<210>  1195
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa43R_ilmn (Illumina)

<400>  1195
ggagttcaga cgtgtgctct tccgatcttt ggtaaaaggg caacaatg                    48


<210>  1196
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa44R_ilmn (Illumina)

<400>  1196
ggagttcaga cgtgtgctct tccgatctat tgggatcagc atcgactc                    48


<210>  1197
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa45R_ilmn (Illumina)

<400>  1197
ggagttcaga cgtgtgctct tccgatctct gcccaccatc tactccat                    48


<210>  1198
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa46R_ilmn (Illumina)

<400>  1198
ggagttcaga cgtgtgctct tccgatctct aactgccctg gagacctg                    48


<210>  1199
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa47R_ilmn (Illumina)

<400>  1199
ggagttcaga cgtgtgctct tccgatctct ccctcccacc ttctcc                      46


<210>  1200
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa48R_ilmn (Illumina)

<400>  1200
ggagttcaga cgtgtgctct tccgatctgt agccgtaggg ggctaca                     47


<210>  1201
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa49R_ilmn (Illumina)

<400>  1201
ggagttcaga cgtgtgctct tccgatctga ccctgccact tacatgc                     47


<210>  1202
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa51R_ilmn (Illumina)

<400>  1202
ggagttcaga cgtgtgctct tccgatctca actctgactg ggtcacca                    48


<210>  1203
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa52R_ilmn (Illumina)

<400>  1203
ggagttcaga cgtgtgctct tccgatcttg cttcccaaga gtttgctt                    48


<210>  1204
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa53R_ilmn (Illumina)

<400>  1204
ggagttcaga cgtgtgctct tccgatctgg ttctaagcaa cactgtgacg                  50


<210>  1205
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa56R_ilmn (Illumina)

<400>  1205
ggagttcaga cgtgtgctct tccgatcttt cttcctcctc gtttccct                    48


<210>  1206
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa58R_ilmn (Illumina)

<400>  1206
ggagttcaga cgtgtgctct tccgatctgc ttagccacct cagcaatc                    48


<210>  1207
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa59R_ilmn (Illumina)

<400>  1207
ggagttcaga cgtgtgctct tccgatcttc aagtttacaa gagggaatac tgaa             54


<210>  1208
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa60R_ilmn (Illumina)

<400>  1208
ggagttcaga cgtgtgctct tccgatcttc aagtttacaa gagggaatac tgaa             54


<210>  1209
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa62R_ilmn (Illumina)

<400>  1209
ggagttcaga cgtgtgctct tccgatctcc attctactca tccacagcc                   49


<210>  1210
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa63R_ilmn (Illumina)

<400>  1210
ggagttcaga cgtgtgctct tccgatctat tcccactaat gcctccct                    48


<210>  1211
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa67R_ilmn (Illumina)

<400>  1211
ggagttcaga cgtgtgctct tccgatcttg agtcctacct cgtgcctc                    48


<210>  1212
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa68R_ilmn (Illumina)

<400>  1212
ggagttcaga cgtgtgctct tccgatctgc tgcagactga atggaaca                    48


<210>  1213
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa69R_ilmn (Illumina)

<400>  1213
ggagttcaga cgtgtgctct tccgatcttc tagcctgggc aacagagt                    48


<210>  1214
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa72R_ilmn (Illumina)

<400>  1214
ggagttcaga cgtgtgctct tccgatctca cgaggagaac cctgagag                    48


<210>  1215
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa74R_ilmn (Illumina)

<400>  1215
ggagttcaga cgtgtgctct tccgatctgg gtttctcttg gtttctttga                  50


<210>  1216
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa77R_ilmn (Illumina)

<400>  1216
ggagttcaga cgtgtgctct tccgatcttt ggcaacatgt ggattcat                    48


<210>  1217
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa78R_ilmn (Illumina)

<400>  1217
ggagttcaga cgtgtgctct tccgatcttg gctaccttgg aaactttga                   49


<210>  1218
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa82R_ilmn (Illumina)

<400>  1218
ggagttcaga cgtgtgctct tccgatctag ccctgttctc tcaccaga                    48


<210>  1219
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa84R_ilmn (Illumina)

<400>  1219
ggagttcaga cgtgtgctct tccgatctaa acttcagttt catcatcatc attt             54


<210>  1220
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa87R_ilmn (Illumina)

<400>  1220
ggagttcaga cgtgtgctct tccgatcttt gcctgcttta ctgcaaga                    48


<210>  1221
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa88R_ilmn (Illumina)

<400>  1221
ggagttcaga cgtgtgctct tccgatcttt gcattgaaag tctctttagg tg               52


<210>  1222
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa89R_ilmn (Illumina)

<400>  1222
ggagttcaga cgtgtgctct tccgatcttc ttcttcagag gtatctacaa ctgttt           56


<210>  1223
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa92R_ilmn (Illumina)

<400>  1223
ggagttcaga cgtgtgctct tccgatcttg gctttcactg tgctgttt                    48


<210>  1224
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa94R_ilmn (Illumina)

<400>  1224
ggagttcaga cgtgtgctct tccgatctgt ggtggcacaa actgacac                    48


<210>  1225
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa96R_ilmn (Illumina)

<400>  1225
ggagttcaga cgtgtgctct tccgatcttg tagtaggagg accgggtg                    48


<210>  1226
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa97R_ilmn (Illumina)

<400>  1226
ggagttcaga cgtgtgctct tccgatctct cgacagtcag ggtggaat                    48


<210>  1227
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa98R_ilmn (Illumina)

<400>  1227
ggagttcaga cgtgtgctct tccgatcttc tactggacgg actggagc                    48


<210>  1228
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa99R_ilmn (Illumina)

<400>  1228
ggagttcaga cgtgtgctct tccgatctaa tccagtcctg ccaatgag                    48


<210>  1229
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa100R_ilmn (Illumina)

<400>  1229
ggagttcaga cgtgtgctct tccgatctgg catgacagag aatcagctt                   49


<210>  1230
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa101R_ilmn (Illumina)

<400>  1230
ggagttcaga cgtgtgctct tccgatctgg catgacagag aatcagctt                   49


<210>  1231
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa103R_ilmn (Illumina)

<400>  1231
ggagttcaga cgtgtgctct tccgatcttt tagggtcttt gcccattg                    48


<210>  1232
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa104R_ilmn (Illumina)

<400>  1232
ggagttcaga cgtgtgctct tccgatcttt tagggtcttt gcccattg                    48


<210>  1233
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa105R_ilmn (Illumina)

<400>  1233
ggagttcaga cgtgtgctct tccgatcttc aagtaatgaa gtctgactca caga             54


<210>  1234
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa106R_ilmn (Illumina)

<400>  1234
ggagttcaga cgtgtgctct tccgatcttg tcattttcag ctatagtact gtttga           56


<210>  1235
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa107R_ilmn (Illumina)

<400>  1235
ggagttcaga cgtgtgctct tccgatctaa tcaaattcct ctaacactcc ctt              53


<210>  1236
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa108R_ilmn (Illumina)

<400>  1236
ggagttcaga cgtgtgctct tccgatctga atgtgtggca tgacttgg                    48


<210>  1237
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa109R_ilmn (Illumina)

<400>  1237
ggagttcaga cgtgtgctct tccgatcttt ggcaacacga aaggtaaa                    48


<210>  1238
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa112R_ilmn (Illumina)

<400>  1238
ggagttcaga cgtgtgctct tccgatctgt tgtccctgga aggtcact                    48


<210>  1239
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa120R_ilmn (Illumina)

<400>  1239
ggagttcaga cgtgtgctct tccgatctcc caaattctgc ctcatcat                    48


<210>  1240
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa122R_ilmn (Illumina)

<400>  1240
ggagttcaga cgtgtgctct tccgatctcc caaacaactt gctttcatag a                51


<210>  1241
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa123R_ilmn (Illumina)

<400>  1241
ggagttcaga cgtgtgctct tccgatctag cttgagggtg aggtggt                     47


<210>  1242
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa124R_ilmn (Illumina)

<400>  1242
ggagttcaga cgtgtgctct tccgatctca ttaacagctg agaaacactg ct               52


<210>  1243
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa126R_ilmn (Illumina)

<400>  1243
ggagttcaga cgtgtgctct tccgatctga gaggcacgag aacacaca                    48


<210>  1244
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa128R_ilmn (Illumina)

<400>  1244
ggagttcaga cgtgtgctct tccgatctca ggtgtgtagc ttggagtttg                  50


<210>  1245
<211>  5610
<212>  DNA
<213>  Oceanicola sp. HL-35

<400>  1245
atgggcccca agaagaagag aaaggtaggc tccggcatga ccacatttct gcagttccac       60

gtgctgacca catatccccc ttctaaccct aatagggacg atcagggccg gccaaagcag      120

gcaaacctgg gaggagcacc aaggctgcgg ctgagctccc agtctatcaa gagggcaatg      180

agggagagcc ctgcattcca gcagggcctg gatggacaca tcggcacacg gaccaagaga      240

ctgggcgagg agatcaggga ggagctggca aagagggagg gcgtgagcac cgatcaggcc      300

ctggacgtgg catctaaggt ggcagccatc ttcagcaagc tggaggcccc cggcaaggac      360

aaggtgcaga agcctctgac cacaaccctg gcctttgtga gcccagatga gtgggcactg      420

gcaagagacc tggcatccag gatgctggca ggagaggaga tgcccaagga taaggagctg      480

aagcgcctgg tgctgcggag agcagatgga gcagtggaca tcgcaatgtt cggaaggatg      540

ctggcagacg agccaggata taacagggag gcagcagtgc aggtgagcca cgcaatcaca      600

acccacagag ccatcgccga ggacgattgg tactctgccg tggacgatct gaataagagg      660

gaggatagcg gcgcaggaca cctgggagag cacggatttg gctccggcgt gtactatctg      720

tacgcctgcg tgaacgtgga tctgctggtg gagaatctgg caggcgaccg cgccctggca      780

gcaaggggcc tggaggccct ggcaaaggcc ctggcaacag caaccccaag aggcaagcag      840

aactctcacg cccaccaccc cagggcaatc tatgtgaggg cagagagggg accacagcag      900

cctagggacc tgaccggcgc cttcttttct gccgtggatc tgaagagcaa tgacatcgag      960

cggacatcca tcatcgccct ggagagaacc gccgagcaga tcgatagggc atacggagca     1020

gcatgcgacg atacagccgt gatggacgtg aaggagggaa acggcaccct ggcagagatc     1080

gcagccttca gcggcgcatc tgtgagcgcc aatgcaggct ccggcgaggg aaggggctct     1140

ctgctgacat gtggcgatgt ggaggagaac cctggacctc cgaaaaaaaa gcggaaagtg     1200

ggctctggca tgagcgacag gaagcaggtc atcggcacat ggtggagaac caggatcggc     1260

gccagaaact ccaccgcagc aagggccctg gcagcacggc tgaatagagg agagggagtg     1320

gatgtgctgg cagagagggc cgtgtttgag ctgggaaggg acctgggctt cctgaagcag     1380

ccaaagcgcc tggtgctgct ggtgcgggtg ctggcagccg tgagggagga taggggaggc     1440

gccctgcctc tgaggctggg ccagggcgac cctccacccc tgagcccact gcggtttcag     1500

agactgctga gggcagaagg agaggagctg acaaccctgc tgaggcgcgc cctgccaatg     1560

gtgacacgca cctgcgacgt gggcgccctg ggagcagacc tgctggattg gtccgactct     1620

acacgcgcaa gatgggcctt tgcctatttc ggcgccaccc ctccagccag aatcaacaat     1680

agcaggccaa cacccgagac ccccgccctg tccgatcagg agacagagga gggcagcggc     1740

gagggaagag gctccctgct gacctgtggc gacgtggagg agaaccctgg acctccaaag     1800

aagaaaagaa aagtcggctc cggcatggca ctgtggcctc ggtctctgcc attcctggcc     1860

cggagatacc tgccaatgcg ggagcacctg gtgtttacac tggccgccgc cgtggcctcc     1920

atgggagagc tggcaggaca cgagaggagg ggcacctggt cttggcccgg cagatctagc     1980

gtgctgggcc tgtgcgcagc cgccctgggc atccggcggg acggcgattt ctccgccctg     2040

gacggactgg gactggcagt ggccgtgttt gatacaggag agccactgag ggacttccac     2100

accgccgtgt ccatcccatc ctctgtggcc aagaggccac agtctcgggc agatgccctg     2160

cgcatcgacg caggccggag caactccaca atcaccctgc gcgattacag ggtgggcgtg     2220

ctgtatggag tggccctgtg gggcgacgga ctgcctaccg tggccgagaa tctggtggag     2280

gccctgcagc gcccaacatt caccctgtac ctgggccgga agagctgtcc actggcagca     2340

ccactggcac cccgcgtgct gacagcccca gatgcagcag ccgccctgac agacggaatg     2400

accctgccac catggagagc aggagcaagg gcaggccaga tcgcaaccga ggaggagctg     2460

cctgcaccaa gaacagagac cagacacgat aggccaacag acaggaccgc ctggcacttt     2520

gcaccaaggg ccgtgcggct ggtgccttgc gatatcgccc caagaacagc aggacaggtg     2580

gcagcaggct ctggcgaggg caggggcagc ctgctgactt gcggcgacgt ggaagaaaac     2640

cctggacctc ctaaaaagaa acgaaaggta ggctccggca tgacactgtg gctgagccgg     2700

gtgcggatcg caagaggagc agacctggat accctgaggc cactgctgga ccccagcgcc     2760

ctgcacccag cagcaatgga ccccaagatg ctgggctccc agacagacgc ccaccacaga     2820

ctgatctgga ccctgtttgc cgattccaga gacaggcgcc gggacttcct gtggagggca     2880

gagggcgccg gcaagtttac actgctgagc ctgagacccc ctaccgcctc cagggtgttt     2940

gaggcccctg aggtgaaggc cttcagccca gatctgctgc caggcgacag gctggccttc     3000

gccctgcggg ccaacgccac ccgcgatcgg gccggctccg ccaagggcag aagggtggac     3060

gtggtcatgc acgccctgca caatgtgcca cccgaggata gggcagcagc aaggatgaca     3120

ctggcacagg atgcagcaag cgactggctg accggacagg gagccagagc aggattcgtg     3180

cccgaggagg tgacagcagg cgactactcc gtggccgccc tgccttctca caccggccgg     3240

agaaagggcc agccacagta tggcatcctg gatctgacag gcgtgctgag agtgaccgac     3300

cctgcagcct ttctggcaag gctgggacag ggatttggaa gagcaagggg attcggatgc     3360

ggactgatgc tgatcagaag ggcaggcagc ggcgaaggca ggggctccct gctgacttgt     3420

ggcgacgtgg aagaaaaccc tggacctccc aagaaaaaga ggaaagtggg tggcagccag     3480

ctggtgaagt ccgagctgga ggagaagaag tccgagctgc gccacaagct gaagtacgtg     3540

ccccacgagt atatcgagct gatcgagatc gccagaaatc ctacccagga tagaatcctg     3600

gagatgaaag tgatggagtt ctttatgaag gtgtacggct atcgcggcga gcacctggga     3660

ggctctcgga agccagacgg agccatctac acagtgggca gccctatcga ttatggcgtg     3720

atcgtggaca ccaaggccta cagcggcggc tataatctgc ccatcggcca ggccgacgag     3780

atgcagagat acgtggagga gaaccagaca aggaataagc acatcaaccc aaatgagtgg     3840

tggaaggtgt atcccagctc cgtgaccgag ttcaagtttc tgttcgtgtc tggccacttc     3900

aagggcaact acaaggccca gctgacacgg ctgaatcaca tcaccaactg caatggagcc     3960

gtgctgagcg tggaggagct gctgatcggc ggcgagatga tcaaggcagg cacactgacc     4020

ctggaggagg tgcgccggaa gtttaacaat ggcgagatca acttctctgc tagcgagaca     4080

cctggcacct ccgagtctgc caccccagag tccggcggct ctggctctag cggcggctct     4140

ggctcctccg gaggaatgac agtgagcctg aatctgatca ccgatcgctg gattcccgtg     4200

ctggacacaa ccggaacacg gcacaccatc gcaccttggg agatggccga cagctccttt     4260

gtggccccag attggcccag acctgacctg aacaccgcct gtctggagct gctgatcgga     4320

ctggtgcgcc tggccgatcc ccctgcacac cccgacgatt gggaggacag gcaggcccct     4380

gacgcagata ggctgaggga tagactggca ccttttgccc cagccttcaa tctgctgggc     4440

gacggcccac gcttcatgca ggagatggga ggactggtgg gcgatgtgcg ggcaacagac     4500

gtgctgttta tcgattccgg cggcgacgga ggcgccctga ccgtgagaga gggcaggtac     4560

ccaaacctgg acctgccaac agcagcaatg gcactgtatg caatgcagac ccaggcacct     4620

agcggcggaa gaggaaatct gacatccctg aggggaggag gaccaatgac cgtgctggtg     4680

gaccccggag gaggaatgtg gcctctgatc tgggcaaacg tgcccgacgg caagccagtg     4740

gtgcctaatg tgctgccttg gatgagaagg acagtgacca gcgagaccgg cgtgaggttc     4800

tttccacacc agggcgatgc cgccgaggtg ttctttggaa tgccacgccg gctgtggctg     4860

gaggcacgca acgactccgt gacaggcgtg atccagcggc cctctggcac caagtatgtg     4920

ggctggcgcc acccactgac accctactat aggcagaagg caggcgatac cccactgccc     4980

gtgaggccta gggcaggcgt gttcggatac aggcactggc tgggaatcgc agcagagcag     5040

ggctctgacc tgagggagag accagcaacc gtggaggcct gggagagccg cggactgggc     5100

agaagggccg atatcatcgt ggccggctgg gccatggaga atatgaaggc aagggactat     5160

atctggtccc gggcacctct ggtgacactg ccagaggaga gagccgcctt tctgagggat     5220

atgatcgagg ccgccgacct gctgtctgcc gccctgaggg gcgccctggc caccctgctg     5280

ggcgagggcg agggcagaga ggccgccagg gaggcctttt acgtgagaac acaggccgcc     5340

ttcgagggct gggtgagctg tctggatacc atcgccctgg acgcagcagc aaggggatgg     5400

ctggccgata tgcggaaggt ggccctggag atcttcgagg tgctggccct gccaggactg     5460

gcagacagaa ccatcctggt gcagcaggag atcgtggcag cacacagggg actgacaggc     5520

agcttctccg gctacggcaa gctgggcacc aaggcctttg gcgtgctgaa cctgcctgtg     5580

ccaacacgga agaaggaggc cgccacctga                                      5610


<210>  1246
<211>  5736
<212>  DNA
<213>  Pseudomonas sp. S-6-2

<400>  1246
atgggcccca agaagaagag aaaggtaggc tccggcatga cacgctttgt gcagctgcac       60

ctgctgacct cttatccccc tgccaacctg aatagggacg atctgggaaa ccctaagaca      120

gcaaggctgg gaggagtgga gagactgagg gtgagctccc agtctctgaa gcgcgcctgg      180

cggacaagcg agctgtttca gcagcagctg gcaggaacca tcggaaccag aacaaagagg      240

ctgggcatcg aggtgttcga ggccctgctg ggagcaggag tgaccgagaa gcaggcaagg      300

gagtgggcag gacagatcgc aaaggtgtac ggagccgcca agaaggataa ccccctggag      360

atcgagcagc tggtgcacat cgcccctgag gagagggcca gcctggacca gctggtggcc      420

acactggcag cagagaagag aggaccaacc gacgaggagc tggatgccct gctgcaccac      480

cagacagccg tggacatcgc catgtttggc aggatgctgg ccagcaagac ccagttcaat      540

ggagaggcag cagtgcaggt ggcacacgca atcggagtgc acgcctccgc catcgaggac      600

gattacttca ccgccgtgga cgatctgaac cgcaatgatc caggagcagc acacatcgga      660

gagtccggct ttgccgccgc cgtgttctac cagtatatct gcatcgaccg ggatctgctg      720

aagagaaacc tgggcggcga cgaggtgctg acacagaagg ccctgcgcgc cctgaccgag      780

gccgccctga aggtcggccc cagcggcaag cagaattcct ttgcctctag ggcctttgcc      840

cacttcgccc tggccgagaa gggcacagat cagccacgct ccctgtctct ggccttcgtg      900

aagccagtgg caggaaccga ctacgcaggc gatgccgtgg ccgccctgca gcaggtgagg      960

gacaacatgg ataaggtgta tggcgtgtgc gccgagtccc gctgtcagtt taatgtgctg     1020

acaggagagg gctctgtggc agacctgctg gatttcgtgg cagcagaggg ctccggcgag     1080

ggaaggggct ctctgctgac ctgcggcgac gtggaggaga accctggacc tccgaaaaaa     1140

aagcggaaag tgggctccgg catgaagcca aggaagcctc ggctgaatga ggcccagcag     1200

agatgggtga gggattggtg gagggccctg cagccaaggg cagagggcga cgagccaatc     1260

cctggagagc tgagcgtgat gggaagggga gagagggcac agctgcggag atgtaccgac     1320

gccgatgagc tgctgacaca gtccgccacc ctgctgctgg cacacaggct ggtggccctg     1380

aacggagaga gaggaccact gcccgataat agcctgtcct atgagaggat ggcatgggtg     1440

gcaggcgtgc tggcaaacgt gaaggacgat ctgagagatg gcaagtccct ggccacccac     1500

ctgggacagg cagcagacgc agagaggcct ccaatgtctg agctgcgctt tcgggccatg     1560

cagagaggca cagccatgca ggagctgttc ctgcactgga ggcgcgccct gcagctggca     1620

ggaggcaaga ccgacgtggc acacctggca gacgatctgc tgagctggca gatcgagcag     1680

ggacagtctg ccgcacaggc cagcaatggc gtgaagtttc actgggccta cgactactat     1740

ctgtctgcca gagatagggc cgccgccaag gagccagagt tcaacaagga gatcagcaaa     1800

ggctccggcg aaggaagggg cagcctgctg acatgcggcg atgtggagga gaaccctgga     1860

cctccaaaga agaaaagaaa agtcggcagc ggcatgaccg actacctgct gctgaggctg     1920

tatggaccac tggcatcctg gggagagatc gcagtgggag agtctaggca cagcgccgtg     1980

cagccttctc gcagcgccct gctgggactg ctgggagccg ccctgggcat cgagagacac     2040

gacgatgcag cacagcaggc cctggtggat ggataccggt tcgccatcaa gctggagtgt     2100

atcggctctc ccctgagaga ctatcacacc gtgcaagtgg gagtgccacc aaggaagttc     2160

cagtttagaa gccggagaca ggagctggca gcagacaagg tggatacaat cctgtccacc     2220

agagagtata ggtgcgattc tctggccctg gtggcagtgg aggccctgcc aggagcaccc     2280

gtggacctgg ccagcctggc agaggccctg cgcaagccaa ggtttgccct gtacctggga     2340

aggaagagct gtccactggc cctgcctctg tccccaaaga tcctggccgc ctctagcgtg     2400

cgcgaggtgt tcgataacct ggagctgcct tctctgctgg gcctgctgga caggtaccag     2460

cctgagcagg cctggccaag cagacaggat cagcaggccc tgaggccagg agtggcaagg     2520

tactattggg aggacggaat gacagcagga atggcacctt cttttgaggc ccagaggcac     2580

gatcagccac tgagcaggcg ccggtggcag ttcgcaccaa gaagggagtg ggtggccctg     2640

aacgatggag gacagtccgg ctctggcgag ggaaggggct ccctgctgac ttgtggcgac     2700

gtggaggaga accctggacc tcctaaaaag aaacgaaagg taggctccgg catgtctcac     2760

tacttcagcc tggtgaggct gatcggctcc cctaggcacg acgcctggct gagggatctg     2820

agcagacacg gagaggccta cagggaccac gccctgatct ggagactgtt ccctggcgac     2880

ggagcagcaa gggatttcgt gtttcgccgg ctggaggatg agaagtcctt ttatgtggtg     2940

tctgccaggc cacctcaggc agacgcagga ctgttccaca tccagtccaa ggcctactct     3000

ccagagctgg cagagggcga ctgggtgagg ttcgatctgc gcgccaaccc cacagtgtct     3060

gtgagaaggg agaatggcag aagccagagg cacgatgtgc tgatgcacgc caagcagctg     3120

gccagcaccg agaagtccgc cctgcccgag cggctggagg cagcaggaag agagtggctg     3180

aaggacaggg cagagcggtg gggcctggac ctgagaaccg attccctgat gcagaacggc     3240

tacagacagc agaggctgaa gcgcaagggc aagcacatcg ccttttctac actggactat     3300

cagggcatcg cccaggtgac cgatcccgag cagctgcgcc gggccctgct ggacggagtg     3360

ggacactcca agggattcgg atgcggactg ctgctggtga agcgggtgga tggcagcggc     3420

gagggaagag gctccctgct gacatgtggc gacgtggaag aaaaccctgg acctcccaag     3480

aaaaagagga aagtgggtgg cagccagctg gtgaagtccg agctggagga gaagaagagc     3540

gagctgcgcc acaagctgaa gtacgtgccc cacgagtata tcgagctgat cgagatcgcc     3600

aggaatccta cccaggatcg catcctggag atgaaagtga tggagttctt tatgaaggtg     3660

tacggctata ggggagagca cctgggaggc agccgcaagc ctgacggcgc catctacaca     3720

gtgggctccc caatcgacta tggcgtgatc gtggatacca aggcctacag cggcggctat     3780

aacctgccaa tcggacaggc agacgagatg cagcggtacg tggaggagaa ccagacaaga     3840

aataagcaca tcaacccaaa tgagtggtgg aaggtgtatc cctcctctgt gaccgagttc     3900

aagtttctgt tcgtgtccgg ccactttaag ggcaactaca aggcccagct gacacggctg     3960

aatcacatca ccaactgtaa tggcgccgtg ctgtctgtgg aggagctgct gatcggcggc     4020

gagatgatca aggccggcac cctgacactg gaggaggtga gaaggaagtt taacaatggc     4080

gagatcaatt tctctgctag cgagacacct ggcacctccg agtctgccac cccagagtcc     4140

ggcggctctg gctctagcgg cggctctggc tcctccggag gaatggacct gctgtctgat     4200

acatggctgc agtgcaggca cagggacggc accctgaagc ctatcgccat cggccagatc     4260

ggcctggagg actgtctgga gctggtggca cctcggcccg acttccgggg cgccctgtac     4320

cagttcctga tcggcctgct gcagacagcc tatgccccag aggacctgca ggagtggaga     4380

gatagatacg ccaaccctcc aaccgccgac gatctggccg aggtgtttgc cccttatagg     4440

gatgccttcc agctggagaa ctccggccca acattcatgc aggacctgac cctgccagac     4500

gatgtgaatc agctgcccgt gctggagctg ctgatcgacg caggctcctc tagcaaccag     4560

tactttaata agccagcagt ggagcacgga atgtgcgagg gctgtttcac acaggccctg     4620

ctgaccatgc agctgaatgc accatccggc ggaaggggca tcagaacatc tctgagggga     4680

ggaggacctc tgaccacact gctggtgcca gccgagcaga acgccaccct gtggcagaag     4740

ctgtggctga atgtgctgcc cctggacgcc ctggatcacc cacctatcaa gatgctgtct     4800

gatgtgctgc catggctggc accaacccgg acaagcgacg ataagcaggg ccaggacaca     4860

ccacccgagt ctgtgcaccc actgcaggcc tactggagca tgcctaggcg gatcagactg     4920

gacgcagcca ccctggacca gggcgattgc gccgtgtgcg gagcacagaa cgtgaagcgc     4980

atccggcact acagaacaag gcacggcggc accaattata ccggcacatg gacccacccc     5040

ctgacccctt attctctgga tagcaagggc gagaagcctc cactgagcat caagggccgg     5100

caggcaggaa ggggatacag ggactggctg ggactggtgc tgggaaacga ggaccaccag     5160

cctgatgccg cccaggtggt gaggcacttc acagccaagc tgggcaagcc atccgtgcgc     5220

ctgtggtgct ttggcttcga catgagcaat atgaaggccc tgtgctggta cgattccctg     5280

ctgccagtgc acggagtggc ccctgacgtg cagaggaagt ttacccgcag cgtgaagcag     5340

gtgctggact ctgccaacga tatggccagc gtgctgcaca agcaggtgaa ggccgcctgg     5400

ttcagaaggc ccggcgacgc aggacaggag cctgcagtga cacagtcttt ttggcagggc     5460

agcgagaccg ccttctatca ggtgctggag cagctgtcca agctggactt tgattctgcc     5520

gcagagctgg cagcaatcta cagagcatgg ctgcaggcaa cccgccggct ggtgctgagc     5580

ctgttcgatc actgggtgct gtccggccct ctggaggaca tggatatgca gcgggtggtg     5640

aaggcaagag cagacctggc caaggagctg aacacaggca aggcccagaa gccactgtgg     5700

accatcgtga atcagcacct gaaggagcag gcctga                               5736


<210>  1247
<211>  5709
<212>  DNA
<213>  Salmonella enterica subsp. enterica serovar Muenster strain

<400>  1247
atgggcccca agaagaagag aaaggtaggc tctggcatga tcatgaccac cttcatccag       60

ctgcacctgc tgaccgcata cgcacctgcc aacctgaata gagacgagag cggcaggcca      120

aagacagcct tcatgggagg agtggagcgg ctgagagtga gctcccagag cctgaagaga      180

gcctggaggg tgtccgagac ctttgaggcc gccatggatg gcttcatggg caagagaaca      240

cggagaatcg gcgtggacta cgtgtatagg cctatgaagg atgccggcat cgaggagaag      300

atcgccaagt ctagctccga gctgatcgcc aagcagttcg gcaagctgaa gagcgacaag      360

gatgccaagc cagagaagaa cctggagatc gagcagatcg tgcacgtgag caatcacgag      420

atctccctga tcaagcagct ggtggacacc ctgatcgccg ataagaggga gccaaacgac      480

gaggaggtgg agctgctgcg caaggagcag cggtccgtgg atatggccct gtttggccgc      540

atgctggcct ctagccccga gttcaatgtg gaggcagcat gccaggtgtc tcacgccctg      600

ggcgtgagcg ccgtgaccgt ggagtccgac ttctttacag ccgtggacga tctgaacaat      660

aaggaggagg atgcaggctc cggccacatg ggagagcagg gatttgcctc tgccctgttc      720

tacacctacg tgtgcatcag ccgcgacctg ctggtggaga acctgggagg caatgaggag      780

ctggccaagc ggacaatcgc cgccctgacc gagacagccc tgaccgtgag ccctacaggc      840

aagcagaaca gctttgcctc ccgcgcatac gcaacctatg ccctggcaga agtgggacag      900

aagcagccac gctccctggc agcagccttc tttcagcccg tgcgggacac cgatcagatc      960

cctgccgcca tcacacgcct gaagcagcag cgggcctctt ttgacaacgt gtacggcaat     1020

tgcgccgacg attataggga gctgaacgtg caggagggaa ccggctccct ggcagagctg     1080

ctggccttcg tgtctcaggg cagcggcgag ggaagaggct ctctgctgac atgcggcgat     1140

gtggaggaga accctggacc tccgaaaaaa aagcggaaag tgggctctgg catgctgaac     1200

agcaataccg ccgtgctgtg cagaatcctg caccctgacg cccagaaggc cctgctggat     1260

tggttcgcca cactgagcga gcggtacgag cggaaggacg gcaagcgcgt gaacggaaga     1320

gcatggaggg cagagctgaa gaggatggca ccaccctacg gcgtgatgat ctgtgaggga     1380

cacgacgccc tgagacaggc cctgctgaag cacatgaggc tgcagcctct ggatgagatg     1440

gcactggccc tgttcgtgag cgtggcagtg cacatcaagt ctcacaaggc caacatcagc     1500

ttcgccgcac agctgggaga gaagctgaag ggctccaccc catgcgtgtc tgtgctgcgc     1560

tttgagcggc tgcagaaggc cagcgacccc gagaccttct gtcagctgct gatccaggcc     1620

gtgaagatca ggggcacaga gggcgtgaat gtgctgtccc tggccgatgg catcttcctg     1680

tggatggagg agtggcagag gcgcgagaac caccagccag agtttcgcaa ccccttcgag     1740

aggaatcgca tccggtgggc caatgagtac ctgtctacca gccgcggcaa gggctccggc     1800

gagggaaggg gctctctgct gacctgtggc gacgtggagg agaaccctgg acctccaaag     1860

aagaaaagaa aagtcggctc tggcatgaag gagtacctgg tgtttcagct gtatgcacct     1920

ctggcaagct ggggagagga ggcctccggc gagatcagac actctgccac cgtgccaaca     1980

aggtccgccc tgctgggact gctggcagcc gccctgggca tccggcggga tgaggaggcc     2040

agactgaaca atttcaatag gcactaccac ctggcagtgc acgccctggc atcccaggac     2100

agatggctga gggattatca caccgtgtct gccccccgcg agaacaagaa gaatcggtac     2160

tataccagga gggacgagct gacactggcc cctgatgaag tgggcacact gatctctcag     2220

cgcgagtacc ggtgcgacgg ctattggcac gtggcaatca gcgccacccc cgatgcacct     2280

cactccctgt ctgagctgcg ggaggccctg ctgacaccac acttccccct gtacctgggc     2340

agaaagagct gtccactggc cctgcctctg gcagcaaggc tgatgaccgg cacactgaag     2400

gaggtgttta cccacgcagt ggaggagatc agcgccgcag agctgtccgg cttcacactg     2460

agagagggca tctgctattg ggacgatcct gacgaggagt ccctggtgtg gcagcagaag     2520

cagcacagca acaatcagcc agtgtccaga cagaggtggc agtttggcgg ctacaccagg     2580

ttcaacggac cactgcagga gaggacaggc tctggcgagg gaaggggcag cctgctgacc     2640

tgtggcgatg tggaagaaaa ccctggacct cctaaaaaga aacgaaaggt aggctctggc     2700

atgtatctga gcagaatcca gctgaggttt aacaatctga gacccgagat gctggccaag     2760

tggaactccg ccaggcctta cgcctctcac cagtggctgt ggcagctgtt ccctgagcag     2820

gagctgagac agttcctgtt tagggaggag gcccacggcg gcttctttat gctgagcgcc     2880

atcccacccc tgtcccagca ctctctgttt ctgatcgaga ccaagccttt caacccacag     2940

ctgacaaatg gcctggagct ggactttcag ctgagagcca accccgtgat cacccgcaat     3000

ggcaagcggt ccgatgtgat gatgaacgcc aagcaccagg ccaaggccaa tggcgtggag     3060

aaggagcggt ggtgggagct gcagcagcag gcagcacagg cctggctgga gcagcagggc     3120

cagcagcacg gctttagact gatcgcccca gagcccgacg atttcgccat gtgggcaggc     3180

gacgagtaca gcgagctgca ggcacactgc ggatgcgtgc aggcctatca gcagcacaga     3240

ttcgtgagga aggatcagca gaagccaatc accttttcct ctgtggactt ctccggcgcc     3300

ctgtgcatca cagatgccgc cctgtttaag caggccctgt tctccggcct gggcaagtct     3360

aaggccctgg gctgcggcat gctgatggtg aagaggaaga gaggcagcgg cgaaggaaga     3420

ggctccctgc tgacttgcgg cgacgtggaa gaaaaccctg gacctcccaa gaaaaagagg     3480

aaagtgggtg gcagccagct ggtgaagtcc gagctggagg agaagaagag cgagctgcgc     3540

cacaagctga agtacgtgcc acacgagtat atcgagctga tcgagatcgc cagaaatccc     3600

acccaggaca gaatcctgga gatgaaagtg atggagttct ttatgaaggt gtacggctat     3660

aggggagagc acctgggagg cagccggaag ccagatggag ccatctacac cgtgggctcc     3720

cccatcgact atggcgtgat cgtggataca aaggcctaca gcggcggcta taacctgcct     3780

atcggccagg ccgacgagat gcagagatac gtggaggaga accagaccag gaataagcac     3840

atcaacccaa atgagtggtg gaaggtgtat cccagctccg tgacagagtt caagtttctg     3900

ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgacccggct gaatcacatc     3960

acaaactgca atggcgccgt gctgtctgtg gaggagctgc tgatcggcgg cgagatgatc     4020

aaggcaggca ccctgacact ggaggaggtg cggagaaagt ttaacaatgg cgagatcaat     4080

ttctctgcta gcgagacacc tggcacctcc gagtctgcca ccccagagtc cggcggctct     4140

ggctctagcg gcggctctgg ctcctccgga ggaatggacc tgaccaaaga gaagtggctg     4200

cctgtgatct tttctaacgg cgagaagaca agaatcagcc tgagggacct gctggataat     4260

cgcatccagg acctggccta tcctcggcca gatttccagg gagcagcatg gcagatgctg     4320

atcggcatcc tgcagtgtac cgtggcccca gaggacaagg aggagtgggc cgatatctgg     4380

cacgagtcta tcgagtttga gcagtgggag aaggccctga acacaatcag cctggccctg     4440

cagttcggcg agcagaagcc ctcttttctg cagagcttcg accctctgga ttccgagtac     4500

ggctctatcg caggactgct ggtggacgca ccaggaggca acgccctgaa gctgaataag     4560

gatcactttg tgaagagagg caacgtggag cagatctgcc cacactgtgc agcaatcgcc     4620

ctgttcgcca tccagaccaa tagccctgca ggaggagcag gctatagggt gggaatgagg     4680

ggaggaggac cactgaccac actggtggtg cctcaggagg aggacaagta cccactgtgg     4740

aagaagctgt ggctgaacgt gctgccacag gaggagcccc ctaatgtgac ccagcaccca     4800

ctgatctttc cctggctggc ccctaccaag acatccgaga aggccggcaa cgtggtgaca     4860

cctgataatg cccacccact gcaggcctac tggggaatgc caaggaggat cgagctggac     4920

ttcacccaca cagtggcagg aatctgcgac ctgtgcggag agcaccacga gtccctgctg     4980

ctgcagatgc gctctaagaa ctacggcgtg cagtatgact cttggctgca cccctttagc     5040

ccttataggc aggccctgaa ggacccctcc gccccatggc tggccttcaa gggacagcca     5100

ggaggactgt cttacaagga ctggctgggc ctgatgctga acagggagga taagtttaat     5160

aagatgcagc cagcaaaggt ggtgcgcgca gcaggccagc ggaataagat gagcctgtgg     5220

tgcttcgcct gggacatgga taaggccaag gtgcgctgtt ggtaccagca cagaatcccc     5280

ctgatctccg tgtctcacga ggagcagttc ctggccgtgc tgaacatcgt gctggtgctg     5340

gccagcgagt ccctgtctct gctgcggaat gccctgaaga gcgccaagtt tgactgccct     5400

aaggaggcca agatggactt ttccatggtg gatatcgcct tctggcagga gaccgagcct     5460

gccttcagaa cactgcagga ggccctggca gtggacccac tgagacagga tacccagaca     5520

aggcacgccg tgagccagtg ggaggcagag ctggcccact atctgtttca cgtgttcgac     5580

cgcgatgccc tgaccaaccc tgattgtcca gacgatatcc tgcagagaca gctgacagca     5640

aggcaggacc tggcaagctc ctacaggaag cacaaggccc ggaaggatgt gctggccctg     5700

gtggagtga                                                             5709


<210>  1248
<211>  5457
<212>  DNA
<213>  Atlantibacter hermannii NBRC 105704

<400>  1248
atgggcccca agaagaagag aaaggtaggc agcggcatga acaacttcat caacttccac       60

gtgctgatct ctcacagccc atcctgcctg aaccgggacg atatgaatat gcagaaggat      120

gccgtgttcg gcggcaagcg gagagtgaga atcagctccc agtccctgaa gagagccatg      180

aggaagtctg actactatgc aaggcacatc ggagcatcta gcctgcgcac aatccacctg      240

gaggagctga gagatgtgct gaggcagaag ctgtcccctc gctttgagct gccaatcatc      300

gacaagaccc tgtccctgct gtctggcaag acaatcgacg atgccgagaa gatcaacggc      360

gacgcagtga ccccatgggt gctgggagag gtggagtggt tctgtgagca ggtcatgaag      420

gccgaggccg agcagctgga cgataagaag ctgctgaaga tgctgaagga cgatatcgcc      480

gccatgagga ccaatctgca gcagggagtg gatgtggccc tgagcggcag gatggccaca      540

tctggcctga tgagcgagct gggcaaggtg gacggagcaa tgtccatcgc acacgccatc      600

accacacaca ccgtggactc tgatatcgac tggtttacag ccgtggacga tctgcaggat      660

ctgggctccg cccacctggg aacccaggag ttttcctctg gcgtgttcta cagatatgcc      720

tccctgaaca tcgcccagct gcaggagaat ctgggaggcg tgtctcgcga gcaggtgctg      780

gagatcgcag cacacctggc acacatgctg gcaaccgagg tgccaggagc aaagcagcac      840

acatttgccg ccttcaaccc cgccgatatg gtcatgatca acttcagcga cttcccactg      900

tccctggcca acgcctttga gagccccatc aaggccaagg acggctacct gctgccttcc      960

atcaacgcct tcaatgagta ctggcagcgg atcgccaagg gatatggact gaccggacca     1020

gcagcacagt tcatgctggc agaggccagc atggcaggag gaaacgtggt gtccgtggag     1080

accctggagc agctgaagaa gtggatctgc cacgatggag aggccagccg gggctccggc     1140

gagggaagag gcagcctgct gacatgtggc gacgtggagg agaaccctgg acctccgaaa     1200

aaaaagcgga aagtgggctc tggcatgagc accgagatcg atgccatggc cctgtataac     1260

gcctggcagc agctggacaa tggcagctcc gcccagctga ggcgcgtgag cgagcctgat     1320

gagctgaggg agatcccagc cttttaccgc ctggtgcagc cattcggctg ggagaacccc     1380

gccaataagc gccctctgct gcggatggtg ttttgcctgt ccgccggcaa ggacgtgatc     1440

caccacaagg agaagatcga cgattaccca tccggcatct ctctgggacg ggccctggca     1500

aagtctggca agatcaacga gcggagagtg ttccagctgg tgagagccca gagcccaggc     1560

gatatgatcc agctgaggcg cctgctgatc cacgcagagc ccgtgctgga ctggagcctg     1620

tttgcaaggc agctgacctg gtggggcaag agggagagac agcagctgct ggaggatttc     1680

atgctggcca cacccgagag caacaagaag gcaggctccg gcgagggaag gggctctctg     1740

ctgacctgcg gcgacgtgga agagaaccct ggacctccaa agaagaaaag aaaagtcggc     1800

tccggcatga agccatatct gatcctgaga ctggcaggac caatgcaggc ctggggacag     1860

cctacctttg agggcaccag accaacagca aggttcccaa cacgctccgg cctgctggga     1920

ctgctgggag catgcctggg catccagagg gacgatcggt ctgccctgca ggccctgtct     1980

gagagcgtgc ggtttgccgt gagatgtgat cagagcttca tcgacggccg gaccatccct     2040

gtgacaggcc tgagagatta ccacaccgtg atggatgcca gggaggacta tcgcggcctg     2100

aagtctcacg agaccatcca gacatggagg gagtacctgt gcgacgccgt gtttaccgtg     2160

gccgtgtggg agagcgagca ggccacactg aggctgccag agctgaaggt ggccgtgtgc     2220

aagccccggt ttaccccttt cctgggcaga aagtcctgcc cactgacaca gcccctgttc     2280

gtggacctgt gcgacgccat caacccttac caggccctgg caaattatgc acctgcagga     2340

ggcgatatct attctgaggc acctccagac ggaccatgcc agacctttac agtgcgggac     2400

gagcctatca tcgccctgcc aaggcagttc gcagcaaggg agtggtacgt gatcaaggga     2460

gcaagcgacg tgagccaggg ctctggcgaa ggcagaggca gcctgctgac ttgtggcgac     2520

gtggaagaaa accctggacc tcctaaaaag aaacgaaagg taggctctgg catgtacctg     2580

agcaaagtga tcatccagaa tgcctggtgt cgcgacgtgt accagtttca ccaggccatc     2640

tggcagctgt tcccctctca gcctgcccag aagcgggcct tcctgtttag aatcgaggca     2700

aagcacccag gaaggggagc agacgtgctg ctgcagagca tggaggcacc agcatctagc     2760

gccgcagcac aggtgctggc ctgcaagccc ctggcctttc acctgaagga gggcgatcag     2820

ctgaggttcc gcctgagggc caacccaatc aagaccatca aggacgagca gcagcggctg     2880

aatggcagag gcgagatcaa gagatgtagg gtgcccctgc tgaaggagca ggagcagcac     2940

cagtggctga tcaggaagct gtccctggca gcacgcctgg agcacatcga gtccacctct     3000

gagctgcccc tgttcttttc taagaacggc acaggcggca agatccagcc tatgaatttc     3060

gagggcatcc tgaccgtgac aagcgtgcct gccctgctgt ccctgctgaa caatggagtg     3120

ggaccagcaa aggcaatggg atgcggcctg ctgtctctgg caaggccagg cagcggcgag     3180

ggaagaggct ccctgctgac ctgtggcgac gtggaagaga accctggacc tcccaagaaa     3240

aagaggaaag tgggtggctc ccagctggtg aagtctgagc tggaggagaa gaagagcgag     3300

ctgagacaca agctgaagta cgtgcctcac gagtatatcg agctgatcga gatcgccagg     3360

aatccaaccc aggatcgcat cctggagatg aaagtgatgg agttctttat gaaggtgtac     3420

ggatataggg gagagcacct gggaggctct cgcaagccag acggagcaat ctacaccgtg     3480

ggcagcccaa tcgattatgg cgtgatcgtg gacacaaagg cctactccgg cggctataac     3540

ctgccaatcg gacaggcaga cgagatgcag cggtacgtgg aggagaacca gacaagaaat     3600

aagcacatca acccaaatga gtggtggaag gtgtatccct cctctgtgac cgagttcaag     3660

tttctgttcg tgagcggcca cttcaagggc aactacaagg cccagctgac cagactgaat     3720

cacatcacaa actgcaatgg agccgtgctg tccgtggagg agctgctgat cggcggcgag     3780

atgatcaagg caggcaccct gacactggag gaggtgcgga gaaagtttaa caatggcgag     3840

atcaacttct ctgctagcga gacacctggc acctccgagt ctgccacccc agagtccggc     3900

ggctctggct ctagcggcgg ctctggctcc tccggaggaa tggatctgct ggtggaccca     3960

tggattcccg tgcgggcctt tgaggagagg caccctcaga ccatcacact gcagcggctg     4020

tgctgttccg aggagaagtg gctgctgaat ctgccaagag acgatatgga gctggccgcc     4080

ctgcagctgc tgatctgcct gctgcaggtg acctgtgagc ctagggacga ttctgagatg     4140

aggctgcggg tggcaaggcc actgtctgag gaggagttcg ccgccctgat gagcccttgg     4200

caccagacat ttcagctgga ccaccctcag atgccattca tgcaggtgaa gggcgtggag     4260

gccaaggagc caacccccat ggagaagctg atgaccggcc tgagcggcgc cacaaactgt     4320

gcctttgtga atcagccagg acagggagag gccctgtgcg gaggatgtac agcaatcgcc     4380

ctgttcaacc aggcaaacaa tgcaccagga tttggaggag gcttcaagag cggcctgagg     4440

ggaggaaccc ctatcaccac actgatcaag ggctccgatc tgcgcaccac aatctggctg     4500

aacgtgctga ccacaccccg gctgcagtcc tcttttcctc cagacagact gaccgagaat     4560

ctgcccacat ggaagaggcc tatcagctcc ggcaagacct ttcctgcagc aacaatcgga     4620

ctgctgaggg gactgttctg gcagcctgca cacatcgagc tgtgcccacc tatcggacca     4680

ggacagtgct gtggatgtgg acagcagtcc aaccagcggt acaatggctt cctgaaggcc     4740

aagtttaatt tcacagtgga gggactgtgg cctcacccac actcccccag agtgctggtg     4800

gagaagaagg gcgtgatcga gcagaagttt ctggccttca ccacagccgc cccttcttgg     4860

acccagatcg gcaggctgct ggtggataag gagacccgcc agggagaggg caggcgcgtg     4920

gccacagtgg tggagcagtt tcgggaggtg taccctagat tcaggctggc cctgatcgtg     4980

ggcggctata gaaacaatca ggccagcatc ctggagcgga gacacgatgt gctggtgttt     5040

aacgacggct ggcagaatgg ctccgatgtg atcaacgaca tcgtggagat gggcctgggc     5100

tacaagaccg ccctgaggaa gggcctgtat acattcgtgg agggcgccaa gaatcacgac     5160

gtgaagggag caggagtggc agtgcacgag gtggccgagc gccactacta taggcgcagc     5220

gagctgctga tcccagcaat cctggcctcc atcgattatt ctcagcctaa cgacgtgatc     5280

gcaaggctgc ggaaggagct gcaccagctg tgcgaggccc tgttcaatca ggtgaccgca     5340

ccatacgcac accacccaaa gctgatccgg tctctggcag tggcaagagc cagcctgcac     5400

aagcacctga acgagctgaa gccacaggga gagctggcat acgtggatgg cgactga        5457


<210>  1249
<211>  5448
<212>  DNA
<213>  Geothermobacter sp. EPR-M

<400>  1249
atgggcccca agaagaagag aaaggtaggc tccggcatgc agaactttat caattaccac       60

gtgctgatct ctcacagccc atcctgcctg aaccgcgacg atatgaatat gcagaagagc      120

gccatcttcg gaggcgtgcg gagagtgcgg atcagctccc agagcctgaa gcgggccatg      180

agaaagtccg actactatgc ccagcacctg ggcgaggcct ctatcagaac caagcacctg      240

agcggcctga gggataggct gcacgagcgc ctggcaggcc ggttcagccc cgaagtgatc      300

gacaagacaa tcaagctgct gatcgacaag gatgtgagcg tggatggaat cgtggagggc      360

gacgcagtgg caccatgggc agtggaggag tttgcatggt tctgtgagag agtgatgaac      420

gcacaggcag agggcctgga ggataaggcc ctgaccaagc agctgaagga gtccatcgcc      480

gccatgagac agacactggt gggcggcctg gatatcgccc tgtctggcag gatggccacc      540

agcggcctgc tgtccgagct gggcaaggtg gacggcgccc tggcagtggc acacgccctg      600

accacacaca ccgtggacgc cgatatcgac tggtttacag ccgtggacga tctgcaggag      660

ctgggctctg gccacctgga cacccaggag ttttctagcg gcgtgttcta cagatatgcc      720

agcctgaaca tcggacagct gcaggagaat ctgggaggag caccaaggga gcaggccctg      780

gagatcgcaa cccacgtgct gcagatgctg gccacagtgg tgccctccgc caagcagcag      840

tctttcgccg cccacaatct ggccgatctg gccctggtgt cctttgccga catccccgtg      900

agcctggcaa acgccttcga gaagccagtg cagcagaaga atggctctgg ctttcgggag      960

ccaagcatcg ccgccctgca cgactactgg cagaaggtgc acatcggcta tggcctggag     1020

gagagatgcg gccagttcgt gctgaacaag gtggagaccc ctgcaggaat cgcagcaaag     1080

gagtccctgg aggatctgaa gtcttgggtg cgcaacaatg gagagggagg cagcggcgag     1140

ggaaggggct ccctgctgac ctgtggcgac gtggaggaga accctggacc tccgaaaaaa     1200

aagcggaaag tgggctccgg catggccaag gagacagatt tcatggacct gtaccaggcc     1260

tggcagagac tgccaaacgg accaaaggca gagctgaaga ggtgcggcga tctgggcgac     1320

ctgctggaga ccagcgcctt ttacagactg ctggcaggaa ggggagaggc agagtggcag     1380

aagaaggcct atcagcggat gatcttctgc ctgccctgta tcaatcacac agagcagaag     1440

atccctctgg gagccgccct ggcacggagc agaaagggca gccggagcgc cgtgagcgag     1500

tctaggatga tccaggtggt gcgctccgag gcaccaaacg atatggtgca gctgaggcgc     1560

atcctgaagc acgcagagcc aaccgtgaac tggcctctga tggccaagca gctgtggtac     1620

tgggacctga atgagaggag caagcggagc ctgctggagg atttctttct gaaccacacc     1680

gacacaagca aggagggagg ctccggcgaa ggcagaggct ccctgctgac ttgcggcgat     1740

gtggaggaga accctggacc tccaaagaag aaaagaaaag tcggctctgg catgggcgac     1800

tatctgatcc tgaagctgca gggacctatg caggcctggg gagagcacag ctttgaggga     1860

acccgcccat ccggcaattt ccccacacgg tctgccctgc tgggactgct gggagcatgt     1920

ctgggcatcc ggcggaacga gtacgagagg ctgcagcagc tggccgatag cgtgcagttt     1980

gccgtgagaa aggacgccag gcagacccag acagagtggg gcgagccaaa gaagctgccc     2040

atggtgaaga tgaccgatta ccacacagtg aaggacgcca gacagtctta tatcggcctg     2100

aagagccacg agaccatcca gacatggagg gagtacctgc tggacgccga gtattctgtg     2160

gccatctggg agaatgagga tgcagccgtg agcctggacg agctggagac cgccgtgagg     2220

aagcccgtgt tcaccccata cctgggcagg cgcagctgcc cactggcaca gcctctgttc     2280

ggcaagcgcc tgaccgcaga gtccccaaac caggccctgc aggcagtgga gccttccggc     2340

ggcgtgatct attctgagca gccctctgat cgcagcatga ggctgaggga cctgcctatg     2400

gcaggacagc caaggcagtt cgcatctcgg accgtgtaca tccacggagg cgatcacgtg     2460

tccgagggct ctggcgaggg aagaggcagc ctgctgacat gcggcgacgt ggaagaaaac     2520

cctggacctc ctaaaaagaa acgaaaggta ggctctggca tgtacctgag caaagtgatg     2580

gtgaccggag cagcatgtag gaacccatat gagatccacc ggtccctgtg gcagctgttc     2640

cccgaggacc ccgacgcacg gagagattat ctgttccggg tggagagagc aggcaggcag     2700

caggcagaga tcctgctgca gagccagcgg aagccaagcg actccgagct gcgcaaggtg     2760

cggctgctgg caaccagagg ataccagcca aggctgcagc agggacagcg gctgagattt     2820

gccctgctgg ccaaccctgt gaagacaatc aatgatgaga ggggccgcct gaacgcaaag     2880

ggacaggtga agaagtgcag ggtgccactg atcagggagg aggagtggag aagctggctg     2940

gagcacaagc tgatcggatg tgcagagctg gagaccctgg tggcagagaa caggctgccc     3000

atcaacttca gaaagccaaa ggagaagagg gtgggcaaga tccagcccgt gagcttccag     3060

ggcatcctga gagtgtcctc tccagaggcc atgatgcagg ccatctctac cggcatcgga     3120

ccagcaaagg ccttcggctg cggactgctg agcatcgcac cagcaggctc cggcgaaggg     3180

aggggctctc tgctgacatg tggcgacgtg gaagaaaacc ctggacctcc caagaaaaag     3240

aggaaagtgg gtggctccca gctggtgaag tctgagctgg aggagaagaa gtccgagctg     3300

agacacaagc tgaagtacgt gcctcacgag tatatcgagc tgatcgagat cgcccgcaac     3360

ccaacccagg atagaatcct ggagatgaaa gtgatggagt tctttatgaa ggtgtacggc     3420

tatagaggag agcacctggg aggctccagg aagccagacg gagccatcta caccgtgggc     3480

tctcccatcg attatggcgt gatcgtggac acaaaggcct acagcggcgg ctataacctg     3540

cctatcggcc aggccgatga gatgcagcgg tacgtggagg agaaccagac ccggaataag     3600

cacatcaacc caaatgagtg gtggaaggtg tatcccagct ccgtgacaga gttcaagttt     3660

ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgacccg gctgaatcac     3720

atcacaaact gcaatggagc cgtgctgagc gtggaggagc tgctgatcgg cggcgagatg     3780

atcaaggccg gcaccctgac actggaggag gtgaggcgca agtttaacaa tggcgagatc     3840

aatttctctg ctagcgagac acctggcacc tccgagtctg ccaccccaga gtccggcggc     3900

tctggctcta gcggcggctc tggctcctcc ggaggaatga acctgctgac agatccctgg     3960

attcccgcaa ggccacaggg aagggcaacc gcacagaagc tgacactgag acagctgctg     4020

tgcgaggacg agaggtggga gctgagactg cccagggacg atatggagat ggccaccctg     4080

cagctgctga tctgtctgac ccaggccctg gcaacaccag cagatctgcc cgagctgaag     4140

cggagaatca tgaagcccct gggccagcag gagtttaatg ccgcctacac cccttttgcc     4200

gattggttcc gcctggacca cccccagtat cctttcatgc aggtgcgggg agtgaaggca     4260

aaggagccaa cacccatgga caagctgctg gcaggactga ccggagcaac aaacagctgt     4320

tttgtgaatc agtccggcct gggagaggga ctgtgcccag cctgtgccgc catcgccctg     4380

ttcaaccagg ccatgaatgt gcctggcttt ggaggaggct tcaaggcctc tctgaggggc     4440

agcgccccag tgaccacact ggtgcaggga gagcacctga ggcagaccat ctggctgaac     4500

gtgctgtcta cagagagcgt ggaggccctg ctgccatggc acaggcagac cgaggaccag     4560

aagcccacat ggatcgcccc tatcaagagc gagaccttca gctccagatc catcggcttt     4620

ctgaggggac tgttctggca gccagcacac atcgagctgc tgcctgcaga gagcgtgggc     4680

gattgctcct gctgtggcca gggcgacaca gaggtgtaca ggggctttaa caaggccaag     4740

ttcaattata ccgtgacagg aatctggcct cacccacacg gagcacgcac cagcacagtg     4800

aagaagggcg agcaggagga gaagttcgtg agcttcacca cagaggcacc tagctggacc     4860

cagctgggcc gctttgtggc aaggagggcc ttcgtggatg caaagacacc tggacaggag     4920

ccagcagccg tgatcaggca ggcacagaag ctgggcgtgc ggctgaccct gtgcatcgga     4980

ggctatagga acaatcaggc cagcatcctg gagcggagac acgagctgct gccactggga     5040

gagggatgga attccaagcc ccagatcgtg caggatgtgg tggacacagc catcggctac     5100

cgcgacgccc tgaacaagtc cctgtattct ttctttaagg gaggaggctc caagggagca     5160

ggactgccta tccacgagtt tggcaaggcc cagttctaca ggcgcaccga ggaggccatc     5220

ctggattccc tggccagact ggacttttct aatcccaggc ctgtgctgct ggccctgcag     5280

aagaagctgg atacagaggt gagaggcctg ttcgaggagg ccgtgaggcc atacctgaac     5340

gaccccaatc tgatccacac catggccgtg agccggagaa cactgtataa gaacctgaat     5400

gtgctgaagc cacagcagga gggaggagtg gacggcaaga gaaactga                  5448


<210>  1250
<211>  5484
<212>  DNA
<213>  Methylocaldum sp. 14B

<400>  1250
atgggcccca agaagaagag aaaggtaggc agcggcatga ccaagaagaa ctttatcaat       60

ttccacgtgc tgatcagcca ctccccttct tgcctgaaca gagacgatat gaatatgcag      120

aagacagccg tgttcggcgg cgtgaatcgg gtgagaatca gctcccagtc cctgaagcgg      180

gccatcagaa agtctgacta ctatcaggcc aacctgggag caccaagcgt gaggacccgc      240

gatctgaata agctgaaggc ccggtttaca gagctgctga aggacagatt cgatgccgag      300

ctgatcaaca gggccctgga gtggatctcc ggcaaggagg gcatcgcaga gggagtgacc      360

gcagacgcag tggccccatg gtctgtggat gaggtgacac acttttgtga gatcatcagc      420

gccgacgatc agcaggacat caagaagctg gagaagcaga tcgagaagga ggcaaggccc      480

ttccgcgcag caatgagcaa caccgtggac atcgccctgt ccggcaggat ggccacatct      540

ggcctgatga gcaatctgcc agtggatggc gccctggcag tggcacacgc aatcaccaca      600

cacgccgtgg agcctcagga cgtggattgg ttcaccgccg tggacgatct gacacaggac      660

gcaggcgata ccggagcagg acacctggat acccagcagt tttctagcgg cgtgttctac      720

agatatgcct ccctgaacct gcgccagctg caagtgaatc tgggcctgat cgaccacatc      780

aaggcagagg agaccgcaga gtctcggcag agagccctgg atatcgccca ccacgtgttt      840

cacctgctgg ccacagtggt gccttccgcc aagcagcagt ctttcgccgc ccacaacctg      900

gccgactttg ccatcgtgag cttcgccgat cagccaatct ccctggccaa tgcctttgag      960

gagcccgtgc ggagagacta caagctggcc ggcttcctga agccatccat ccagtgcctg     1020

gccaactact ggggccggat gaatagagca tatggcctgg acgagcaggc aagggccttt     1080

gccgtggatg ccagcttcga gatgggcggc aagccccctc tggattccct gaaggccgtg     1140

gaggactgga tcgccgagga tggacaggag ggcagcggcg agggaagagg ctccctgctg     1200

acctgtggcg acgtggagga gaaccctgga cctccgaaaa aaaagcggaa agtgggcagc     1260

ggcatgacag cagagctgcc agattttgtg gccctgaaga tgcactatga cgatgagtcc     1320

ttccccaccg gagcaagggc agagctgagg cgcgcagccg agcctgacga tgtggccctg     1380

acaccagccc tgtacaggct gtttcctgga gagaggccat ctgacaggca cctgcgcgtg     1440

gcatacctgc tgccctatgc caagcacgcc gccaaggcca agagcctggg agcacagctg     1500

gcagaggcaa aggtggccga ggcccgggtg ctgcaggtgg ccagagcaca cgagcccctg     1560

gacgtggtgc agctgcggag actgctgatg caggtggagg cagcagtgga ttggtccgcc     1620

tttggcccta tggtgtggtt ctggaacgag cgggccaaga gacagctgat cgaggacttt     1680

tatatcgccc gcttctctcc agtgaccgga gcaaagggct ctggcgaggg aaggggcagc     1740

ctgctgacat gcggcgatgt ggaggagaac cctggacctc caaagaagaa aagaaaagtc     1800

ggcagcggca tgcctcggta cctgatcctg ctgctggacg gaccaatgca ggcctgggga     1860

acacacacct ttgaggattt cagaccctgc aacgccttcc ctaccaggag cggcctgctg     1920

ggactgctgg gagcctgtct gggcctggac aggcgcgata cagaggccct ggagcagctg     1980

gccatgtccg tggagtttgc cgtgagggca gacagggagg tgctgaggcc agaggcagag     2040

gtgccaaagg caaaggcagc agtgaagctg ccagatttcc acaccgtgga ggacgcccgc     2100

aaggtggatg gctctgccaa caagaatccc gtggtgagcc ggagagagta tctgtttgac     2160

gcagccttca ccgtggcaat cggagcaaag cctgacggac cagtgacact ggatgcaatc     2220

gcagaggccc tgaggcgccc ctgctttacc cctgtgctgg gccggagatc ttgtccaatc     2280

gccagaccac tgctggacgg agaggcagtg gaggccagcg atgccaaggc cgccctggca     2340

accatcgcac cagtgggcgg catgatctat acagagggag agctgatctc cgcccagcca     2400

ctgagggtgc gcgacgtgcc tatccagggc cggcacagac agttctctac ccgcctggtg     2460

tacctgcaca agggcgagac atgcagcggc tccggcgagg gaaggggctc cctgctgact     2520

tgcggcgatg tggaagaaaa ccctggacct cctaaaaaga aacgaaaggt aggcagcggc     2580

atgtttctgt cccgcgtgga gatcccatgg gacgccgtgc ggaaccccta cgagatccac     2640

aggcagctgt ggaggctgtt cccaggagag gataaggagc ctcgcaagaa tgccgaggag     2700

ggcaggcagg gcttcctgtt tcgcgtggag aacaatcagc ccggccggcc tctgagactg     2760

ctgatccaga gcaggagggc ccctgagcca acagcaggac tgaccatcgt gggcacaaga     2820

gagtttcagc cacagcctgc acacggacag aggctggcct tcctgctgac atctaaccct     2880

gtgaagacca tcatcgacgc ccagcgcgag accaagagcg gcaagtcctc tgagaagtgc     2940

cgggtgccac tgatccacga gtccgagcag agggagtggc tgaagaggaa gctgatcgga     3000

gcaggagagt tcgagggagt gaacgtggtg ccacacgcac ccgtgttctt tcggaagggc     3060

aatagaggcg gcaagatcgt gatggtgacc tttgagggcg tgctgagggt gaacgagcca     3120

ggcacactga tcgcctatct ggagaatggc atcggaccag caaaggcctt cggctgcgga     3180

ctgctgctgg tgcggagact gggaggctcc ggcgagggac gcggctctct gctgacctgt     3240

ggcgatgtgg aagaaaaccc tggacctccc aagaaaaaga ggaaagtggg tggctctcag     3300

ctggtgaaga gcgagctgga ggagaagaag tccgagctga gacacaagct gaagtacgtg     3360

cctcacgagt atatcgagct gatcgagatc gcccggaacc caacccagga cagaatcctg     3420

gagatgaaag tgatggagtt ctttatgaag gtgtacggct ataggggaga gcacctggga     3480

ggctcccgga agcccgatgg cgccatctac accgtgggct ctcctatcga ctatggcgtg     3540

atcgtggata caaaggccta cagcggcggc tataacctgc ctatcggcca ggccgacgag     3600

atgcagagat acgtggagga gaaccagacc aggaataagc acatcaaccc taatgagtgg     3660

tggaaggtgt atccaagctc cgtgacagag ttcaagtttc tgttcgtgtc tggccacttt     3720

aagggcaact acaaggccca gctgacacgc ctgaatcaca tcaccaactg taatggagcc     3780

gtgctgagcg tggaggagct gctgatcggc ggcgagatga tcaaggccgg cacactgacc     3840

ctggaggagg tgaggcgcaa gtttaacaat ggcgagatca acttctctgc tagcgagaca     3900

cctggcacct ccgagtctgc caccccagag tccggcggct ctggctctag cggcggctct     3960

ggctcctccg gaggaatgaa tctgctggag gacccttgga ttcccgtgcg ggcagatgga     4020

ggaaccggag cattccagct gctgacatac aggcagctgc tgtgcgagcc aggaaactgg     4080

caggtgagcc tgccaaggga cgatctggag ctggcctgcg tgcagctgct ggtgtgcatg     4140

acccaggtca tgtttctgcc tgagaatgac gccgtgtgga ggaagcgcct gaccgaggcc     4200

ctgacaagag aggagttcac agccggcacc gagccatgtc tggactggtt tgacctggat     4260

caccccaccc agcctttcat gcagtctagg ggcgtgcgcg cagcagagga tacaccaatc     4320

cagaagctgc tgatcggcct gcctgagggc aacaatcacg ccttctttaa tgaggcagga     4380

gaggtgcggc acctgagcgt gaccgtggcc gccatcgccc tgttcaacca ggccacaaat     4440

tgcccttcct ttggcggagg cttcaagggc tctctgaggg gaggagcacc aatcaccaca     4500

ctggtcaacg gcgagaatct gcgggagacc gtgtggtgta acgtgctgac acggtccaga     4560

ctggcagcaa ggcagatcgc aatgccaggc ctggacaggg ataggcctac ctgggtggag     4620

ccaatccagg agaaggccac catcccctgg aatacaatcg gactggcaag gggactgttt     4680

tggcagcctg cccgggtgga gctggtgaga agcatggcag cagcaccttg cgacgtgatg     4740

ggaggagcac caaccctggg atatgtgggc ttcagaaagg agaagtttaa cttcacagtg     4800

gagggcgtgt ggccacaccc acacggagcc atcacaatga ccctgaagaa gggcgccctg     4860

gagcagaagt ttgccagctt caccacaacc gcacctgcat ggacccagct gtccgagttc     4920

gtggtgccaa agggagtgaa cgatccagga gcaaaggagg gctccatccc agcaggacca     4980

gtgacccagg cctccgagct gggagagtct ggcctgcacc tgctggtggg aggatacagg     5040

acaaatcagg ccagcgtgct ggagcggaga cacgagatga tgtccctggc ccggggctgg     5100

agagacgata agagccggct gccaaagctg gtggagatgg gcaaggaggc caagaaggcc     5160

ctgaggggca agctgtattt tgccgtgcag ggcaacaagg acaagggcct gaagggaatc     5220

ggagcagcaa tccacgagac cgccgagaag ctgttctacg ccagaacaga gtctctgatc     5280

cacgagacct tcagcaatga gctgaccttc aagcagtggg ccacagccag aaaggccttt     5340

gtgcaggagc tggcaggaca ctgtagggca atcttcgagg agctgaccgc cccctacgcc     5400

atgaagcctg agctgatccc agtgatcgca tgggcaaggc gcagcctgaa cttcgacctg     5460

acaaagctga tggaggatgc ctga                                            5484


<210>  1251
<211>  5910
<212>  DNA
<213>  Methanocella arvoryzae MRE50

<400>  1251
atgggcccca agaagaagag aaaggtaggc agcggcatga agctgatcga gatccacatg       60

atccagaacc acgccccctg caacctgaat agagacgata ccggcagccc taaggactgt      120

atgtttggag gcatccggcg gagccggatc agctcccaga gcatcaagag atccatcagg      180

atgtctccta tcttcaagga ggagatgaag ggcatcgagc tggccaatcg cacaaggcgc      240

ctgccagagc tggtgaaggc caagctgatc tccgatggca tcgacgagaa gatggcagca      300

atcgcagcag agaaggcaac aggctttggc accaaggatg gcaaggagcg ggaggaggac      360

ctgaatacag cccagaccat gttcatcacc cagtccgacg tggatgccgt ggcctctgtg      420

atgaaggatg ccatcctgaa ggccggcaac cccaaggcct tcaaggatat gaaggcagca      480

gacctgcaga aggcagcaga gctgaaggga tggagaccag tgacacctga cctggccctg      540

tttggcagga tgatcaccag cgatgccttc atggacatcg aggcctccat gcaggtggcc      600

cacgccatct ctacaaataa gatggatcac gagtttgact acttcaccgc cgtggacgat      660

ctgcagaagt ctagcgacgg acctggagca gatatgatcg gcgacgtgca gtttaacagc      720

gcctgctact ataagtactt ctccctggac tatgatgccc tgatccagaa cctggccggc      780

ctgaagccag gcgataatgc caccgaggcc gacaagaagg cctatgccga gtccctggag      840

aatgccaaga aggtggccgc catcaccatc acagcctttc tgaaggccgc catctacacc      900

acaccatccg gcaagcagaa ctctttcgcc gcacaccagc tgccaagcgc cgtgctggtg      960

gagatcaggc caaccaagac acccgtgtcc tacgcaaacg ccttcgtgga ccccgcaagg     1020

ccccgcaatg gcgtggatat ggtggaggac accctgaaca agttcgtgaa gcacgtggag     1080

ctgcagacag agaagtttaa cctgcggagc acccggagac tgtggttcgt ggcaggcgac     1140

aaggccctgg caggaaccga gacatgccag acaatcaacg atctgatcag cggcatcaat     1200

tccgccctgg gctctggcga gggaagaggc tccctgctga cctgtggcga cgtggaggag     1260

aaccctggac ctccgaaaaa aaagcggaaa gtgggctctg gcatgacagc cccaaacgag     1320

aataaggagc accagaagag caagaaggac gaggagttcc tggccaacct ggcaaagatg     1380

gcagagagcg ataggggagg aatggccatc ctgaagcgga acgccggcaa tacaatcgcc     1440

gagagccggg gcgccatgaa gaccttttac agcctgctgc catatggcat cagcgactcc     1500

ccctacgagg agatctattt cctgatcgcc accctgtacg gccacaacaa gtataggttt     1560

acaggcgact tcggccagac catgaagctg gtgcgcgagt cctctaattc tgagagcatc     1620

gatcagcggg tgagcacact gctggattcc gagtttaaca tcgtggacgg catcaagcca     1680

ggaggaggag agctggcata caggctgagg cagtgcgtga agctggcaag cggccacgag     1740

atcggagtgg attggtatag actgctgcag gacctgaagt actggggcta tccagagaag     1800

agggtgcaga agcggtgggc ccggtcctac ttcggctatg gcaagcccgt ggagtctgag     1860

accaaggaga gcaaggagga ggcaaaggca ggctctggcg agggcagagg cagcctgctg     1920

acatgcggcg acgtggaaga gaaccctgga cctccaaaga agaaaagaaa agtcggctct     1980

ggcatggata acccactgct gctgctgctg cggctggagg gaccaatgca gagctggggc     2040

ctgaaggcaa gatgggatat cagggacaca ggcgatgagc ccaccaagag cggcatcatc     2100

ggactgctgg gatgcgcact gggatacgcc agaaaggacc ccaggctgac cgacgagctg     2160

gattcccagc tgcgcatcgg catccgggtg gagtgtcctg gcgagatcgc cagggactat     2220

cacacagtga gcggcgagct gcgcaccgca gagggcaagc tgcgggagac cacaatcgtg     2280

tcctttagag attacctgca ggacgcagcc ttcctggtgg tgctggaggg accaggagag     2340

ctgctgacca ggatctccaa cgccctgaag gaccccgtgt ggccaatcta cctgggcaga     2400

aagtcttgcc ctccaacaag gcccgtgttc gagaccctga ccacagacta tgcctccatc     2460

gacgatgccc tgagccggca cccttggagc tccggcacca tggaggcaag gaaggcacac     2520

ccaaaggagc tgaagtgtat cgtggaggac ctgtctggcc cataccagag aacagatagg     2580

atgaccaaga gccccgccag aatgtatggc atccgccacg tgcggatgag caccgtgaag     2640

ctgcaggcag agggagaggg actgggcagc ggcgagggca ggggctccct gctgacctgc     2700

ggcgacgtgg aggaaaaccc tggacctcct aaaaagaaac gaaaggtagg ctccggcatg     2760

tacctgtctc ggctgatcct gaaccctagg acccgcgccg tgaggcgcga cctggcagat     2820

tgtcacgagc tgcaccgcac aatcctgggc ggctttccag acctgaacgg caagggagga     2880

gaggcaaggg agaccttcgg cgtgctgcac agaatcgata tccacccaag gagcggcgca     2940

atcgtgctgc tggtgcagag ccaggagaag cccgactggt ccaagctgcc tgagggctac     3000

ctgctggaga acaccggcac agagaatcct gcctgcaagg ccatcgacga gcagtacggc     3060

aagatcaagg caggcgacgt gtacgccttc cggctgagag ccaatccaac aaagaagatc     3120

ggcaccagcc ggatcgagga tatcaaggcc ggcaagccca agaacaatgg ccggagagtg     3180

cctatccgca acgagagcga ccagatcctg tggctgaaga ggaagggagc agcaggagga     3240

tttgagctga tgagcaccaa gaggttcagc gagctgtccg acgtgctgat ctccgaggag     3300

ggccaccaga agatctatac attcgatacc ggcatcaagg ccaaggtgca gaagaacgcc     3360

agagagaata ggctgacctt tggcagcgtg ctgttcgagg gcacactgaa ggtgaccaat     3420

gccgagaagt ttctggagac actgaagagc ggcatcggct ccggcaaggc ctacggattc     3480

ggactgctgt ccctggcacc tgcaaggggc tctggcgagg gacggggcag cctgctgact     3540

tgcggcgatg tggaggagaa ccctggacct cccaagaaaa agaggaaagt gggtggcagc     3600

cagctggtga agtccgagct ggaggagaag aagagcgagc tgcggcacaa gctgaagtac     3660

gtgccccacg agtatatcga gctgatcgag atcgccagaa atcctaccca ggatagaatc     3720

ctggagatga aagtgatgga gttctttatg aaggtgtacg gctatagagg agagcacctg     3780

ggaggctcca ggaagcctga cggagccatc tacacagtgg gctctccaat cgattatggc     3840

gtgatcgtgg acaccaaggc ctactccggc ggctataacc tgccaatcgg acaggcagac     3900

gagatgcagc ggtacgtgga ggagaaccag acccggaata agcacatcaa cccaaatgag     3960

tggtggaagg tgtatccctc tagcgtgaca gagttcaagt ttctgttcgt gtctggccac     4020

tttaagggca actacaaggc ccagctgaca cgcctgaatc acatcaccaa ctgcaatgga     4080

gccgtgctgt ccgtggagga gctgctgatc ggcggcgaga tgatcaaggc cggcaccctg     4140

acactggagg aggtgaggcg caagtttaac aatggcgaga tcaatttctc tgctagcgag     4200

acacctggca cctccgagtc tgccacccca gagtccggcg gctctggctc tagcggcggc     4260

tctggctcct ccggaggaat gaagaatcgc gtgaagcggg gcgagcacct ggtgtcttat     4320

aacctgctga cagagccttg gatcacctct atcgatctga gcggcaatcc agtgcaggag     4380

ggcatcctgg ccaccctgaa gaacgcccac aagatcgata gcatctttga ccctgcccct     4440

ccagtggagt tcggcatcta caggctgctg atcgccttta tcaccgacgt gttccagcca     4500

cagggcctgg aggacctggc agatctgctg gacaggaagc ggctggaccc cacagccctg     4560

gacgagtacg cagcacggtg gagagatagg tttgacctgt tcgatgagaa gtatccattc     4620

ctgcagcagg ccatcaccgg cgtgatcaag aagccccctg agcccatctc tcgcctgatg     4680

cagcacctgc ctgccggcac aaatgtgagc cactttcacc acggccggtg ggacgagaac     4740

tcttttagct tcgagcagtg cgccaagggc ctggtgacaa tcgcaccctt catgaccgca     4800

ggaggagcag gcctgtcccc ttctatcaac ggcagcccac cctggtacgt gctggtgaag     4860

ggcaacaatc tgtttgagac actgctgtat aacgtgtgcc agatccccat gaccgtgaag     4920

cctatcggcg atagcccagt ggcctggaga aacgacaaga ggatcgaccc tggcgatgag     4980

ccaaagacat tctccatcgt ggagggactg acctggaggc ctcggatcat ccagctgatc     5040

ccaggcaatg gcaagggcac ctgtacatat accggcgaga aggacgtgga taccgtgtcc     5100

cacatgcact actatccagg ccagaagtct cctgagccag gactgtgggt ggacccccag     5160

gtggcataca agaagacaaa ggatgccatc agacccctga ggcctgacga gaataaggcc     5220

ctgtggcgcg atatcggacc actgatgctg ctgcagcacg gcgattactc tggcaaggac     5280

ggcaaggtga gcttcgatcg gccagccgtg gtgacccagt ataagcagat ggtgtccaac     5340

ggcatgatca agcggagcga gccactgcgg ctggaggtgt acggcatccg cacagacggc     5400

aagatgaaga tctacgagtg gtatcacgag aagctggccc tgcccatcga gatcctgaag     5460

aaggccaatt ccggccggca gatccaggac gccatggatc tggccgactc tgtggcctac     5520

atcctgagaa aggccatgaa gaaggcctat cctaggaacg ccaagtccaa tgagtctggc     5580

tttgacaacc tgatcctgag cgtgcagtct agctattggt cccacctgaa gggccagttt     5640

gagtctatct tcctgaagac actgagccag caggatgaga atgacctgga tgcctacacc     5700

aagctgatgg agcagtggaa gaagatcctg gacgatacag gcaagaacgc cctggacaag     5760

ggactgggac ccctggacac cgatggcgac tccctgcgga gacaggtgaa ggccatgaac     5820

gagtactcct ctggcatcag attcgccctg tatcctgact ctatccaggc caagaagaag     5880

aacaggcaga agaataagga ggataagtga                                      5910


<210>  1252
<211>  5592
<212>  DNA
<213>  Pseudomonas aeruginosa DHS01

<400>  1252
atgggcccca agaagaagag aaaggtaggc agcggcatga acctgtttat cgagttccac       60

ctgatccaga attttgcccc atccaacctg aatagggacg ataccggagc accaaaggac      120

gcaatctttg gaggacacag gagagccaga gtgagctccc agtgcttcaa gagagccatc      180

aggctgaccg cccacgagca ggagctggtg gcccccgagc acaggggcgt gcggacaaag      240

aagctgaagg ccctgctgct ggagaggctg gcaggacgcg atcctgcaga ggcagagggc      300

aagatcgaga ccgccctggc agcagcaggc ctgaagctga aggacgatgg caagacagag      360

tacctgctgt ttctgggaga ggcagagatc gcaggattcg ccgccctgat cgagcagcgg      420

tgggacgagc tgggcagcgc cgcaccagcc ggcgagaaga agggcaagaa ggaggccaag      480

gccaacgtgc ccaccgaagt gatcaagcag gcaagggccc tgctggatgg aggcaaggca      540

gtggacgtgg ccctgttcgg aaggatgctg gccgatctgc cagaggtcaa tcaggacgca      600

gcatgtcagg tggcacacgc aatctccacc cacagggtgg agagggagtt tgactacttc      660

acagcagtgg acgatagggg aggccccgat gagtctggcg caggaatgat cggccaggtg      720

gagtttaaca gcgccaccct gtacagatat gcagtggtgg acctgcgcaa gctgctggga      780

aacctgcaga atgatggaga gctggtgctg tccgccctgg aggccttcac ccaggcaatg      840

gtgcgcgcaa tcccatctgg caagcagaac acatttgccg cccacaatct gcctgccttc      900

gtgggaatct gcctgaggca cgcaggacca ctgaacctgg ccaatgcctt tgagaagcca      960

gtggtggcaa gggcagacgc ctccctgtct gagcggagcg tggcagagct ggcaagacac     1020

gatcagcagc tggcaagcgt gtacggcgac agccgggata gatgggccta tctggacatc     1080

tccggcgcat ggccaaagga gagaggagag ccagcaggaa acctgcagca gctggccgat     1140

tggctgaggt ctcaggtgtc tagccgcctg ggaggaggca gcggcgaggg acggggctcc     1200

ctgctgacct gtggcgatgt ggaggagaac cctggacctc cgaaaaaaaa gcggaaagtg     1260

ggcagcggca tgtccgccgc agagcaccca ttcatcggac acctgcagag gctgcagaat     1320

gacaggggcg ccctggccgt gctgaggcgc agcctgggat ttgcacctgg agcatatgtg     1380

ccagcatacc catatgtgga gcggttcgtg ggagcagaga gacacgcaca ggatgcctgg     1440

aggctggccc tgtacctgac cgcaggactg tttgcatccc acccaggaca gggaagggcc     1500

tctctggcaa tgaggttcgg agagctgatg aaggccagga acagcgcctc catcgagaag     1560

cggttcatcg ccctgctggc agcagacgca gagaatctgc ccgtgtatct gagacaggcc     1620

gtgagcctgc tggcagcaga taagctggcc ttcgactacg gcgccctgct ggacgatctg     1680

gcacactggc tggaccccta tctgccagtg gcaaggggcg acgcaatcag gcagcggtgg     1740

gccagagact tctacgccgc cctggccaac accacagata cctctctgca caaggacggc     1800

agcggcgagg gaaggggctc cctgctgaca tgcggcgacg tggaggagaa ccctggacct     1860

ccaaagaaga aaagaaaagt cggctccggc atggccaccc tgctgatgag gctgcaggga     1920

ccaatgcagt cctggggaac cacatctcgg ttcgacgaga gagatacaca gctggagcct     1980

tctaagagcg gcgtgctggg actggtgtgc gccgccctgg gaagggatag aagcgagcca     2040

ctggaggacc tggcctccct gcggatgggc gtgcgcgtgg atagggaggg catccccctg     2100

agagactatc agaccgcaac aggcgtgctg gtggcatccg gcaaggccga tcccaggaga     2160

accgtggtgt ctcctcggca ctacctggcc gacgccgtgt ttctggtggg cctggagggc     2220

agagatcagg ccctgctgga gagaatccag caggccctga gagcaccatt ttggcctctg     2280

tgcctgggaa ggaagagctt cgtgccaggc tcccccgtgt ggctgcctga gggactgtcc     2340

tctctggccc tggagcaggc cctgcaggcc tggccaagac tggcagaggc acagcctggc     2400

gacaggggca agccactgag atgtctgatc gaggacgaga ggagcggcgt ggtgcgcctg     2460

gatcagccta tcgcaccatt cgccgagagg cgctttggac caagattcgt gaggtccggc     2520

gtggcagacg tgcccgatca gaccgaccct ggctctggcg agggaagggg cagcctgctg     2580

acctgtggcg acgtggaaga aaaccctgga cctcctaaaa agaaacgaaa ggtaggctct     2640

ggcatgtatc tgaccaggct gaccctggac ccccgcagcg cccaggcacg gagagatctg     2700

ggcgacgcct acgagatgca caggaccctg agccgcgtgt ttgcagacga gcaggcacca     2760

gcatcccggt tcctgtggag actggaggcc tctggcaacg cctggagcac ccctacactg     2820

ctggtgcagg cagcatccga gggaaattgg tctgtgctgc aggccctgcc aggatacctg     2880

ctgggagagc cacagtccaa gtctctggcc ctgaggcagt ggctggagtc tgacatcagc     2940

tacaggtttc gcctgttcgc caatcccacc gtgacaaggc agggcaagcg gtacggactg     3000

gtgggagagg agcagcagct ggcatggctg gcaaggcagg gcgagagaca cggctttgtg     3060

gtggaggccg ccctggtgac cttcagcgag gtgctgggct cccggaagag acagacacgg     3120

atctccgtgc tgagagccgc ctttgagggc aggctgcgca tctctcgccc agatgccttc     3180

ggccaggccc tggtggcagg aatcggaccc gccaaggcct tcggctgcgg cctgctgtcc     3240

ctggcaagga gcggctccgg cgaaggcagg ggctctctgc tgacttgcgg cgacgtggaa     3300

gaaaaccctg gacctcccaa gaaaaagagg aaagtgggtg gctctcagct ggtgaagagc     3360

gagctggagg agaagaagag cgagctgaga cacaagctga agtacgtgcc tcacgagtat     3420

atcgagctga tcgagatcgc ccggaatcca acacaggata gaatcctgga gatgaaagtg     3480

atggagttct ttatgaaggt gtacggatat aggggagagc acctgggagg cagcagaaag     3540

cctgacggag ccatctacac cgtgggctcc ccaatcgatt atggcgtgat cgtggacaca     3600

aaggcctact ccggcggcta taacctgcct atcggccagg ccgacgagat gcagaggtac     3660

gtggaggaga accagacccg caataagcac atcaacccta atgagtggtg gaaggtgtat     3720

ccaagctccg tgacagagtt caagtttctg ttcgtgtctg gccacttcaa gggcaactac     3780

aaggcccagc tgacccggct gaatcacatc acaaactgta atggagccgt gctgtccgtg     3840

gaggagctgc tgatcggcgg cgagatgatc aaggccggca ccctgacact ggaggaggtg     3900

aggcgcaagt ttaacaatgg cgagatcaat ttctctgcta gcgagacacc tggcacctcc     3960

gagtctgcca ccccagagtc cggcggctct ggctctagcg gcggctctgg ctcctccgga     4020

ggaatgaccg agcactataa cctgctggac acaccatggc tgcctgtgcg gctggcaaat     4080

ggagaggtga gagagatggg cctgctggag gtgtacaggg aggcagagag gatctctgcc     4140

ctggcagaga ccgagccacc cagcctgatc gcccagtacc ggctgctgct ggccatcaca     4200

cacagagccc tgctgctgga gtatggagca tggaaggact ccggccggct gagatggttt     4260

agggagggcc tgcctatcga tgtggtggag cggtacctgg agcggtggag ggagcggttt     4320

tggctgttcc acccacagta tcccttcatg caggtggccg ccctggcaag cgccgcagag     4380

acctgcgata agcagaagcc atgggcacag atcagcctgg catccgccaa cggcaataca     4440

cctgtggtgt tcgatcactc ctacgacctg gccccatctg ccgtgagcgc cgaccgggcc     4500

ctgtgcgcac tgctgggctt tctgcagttc accccaggag gactggtgaa gacagtgcgc     4560

gacagcgata aggcaggcgc cctggcaaac accgcagcag tggtgccact ggcagacagc     4620

ctggcaaaga cactgtgcct ggccctgcac ccagcatccg gcgaggcagc ctttgatctg     4680

cctgcctggg agagagaggc cctgaccatc ccacagctgg cagccgaccc tatcctggca     4740

tccggcccaa atgatcgcta tacacggcag agccgggccg tgctgctgct gcccgaggag     4800

gagggctgcg tgcggtggat cagattcgca gcaggacagg ccctggcaga cgatgtgcag     4860

gcccctgacc caatggccag ctacaggcct ggcgccaaca attccatggt gcgcctgtct     4920

tttggcgaag gccgggtgtt ctggagagat ctgcctagcc tgctgccaga ctccgccgca     4980

gcaggctcta agagggcagc cgtgctggac tgggcaagca acctgcgctc catcggagca     5040

gatgcaccta gctccatgct gctggtggca ggactggcaa gcgatcaggc caagctgctg     5100

agatggaggt ccgagaccgt ggtgctgcca gccgccctgc tggactctga gggatgcgca     5160

aacgagctgc ggagatgtat ccgggagagc gaggatctgt atggcgagct gagaaagatc     5220

gcagtggcaa tgctggcaga ggccctgccc gatcctgcat ctaaggacac ctgggcaagg     5280

gcacggacca gcttcgacaa tggaccagca gcagcaacat acttcgcact gctggagagg     5340

tccctgcctt ctctgatggc cctgatcggc ggcgatcgcc tggagatgct ggacgaggca     5400

gaggccttct ggagatctag gctgctggcc gccctggagg tggcatggca gggcgtgcgg     5460

gagggactgg gcctgagcgt ggccgccctg agagcagagg caaaggtgcg cccaaggtac     5520

ctggccctgc tgaggcgcta tcggagcgag agaacctcta gcacacccct ggccgaggag     5580

cagtgcgcct ga                                                         5592


<210>  1253
<211>  5562
<212>  DNA
<213>  Lachnospiraceae bacterium KH1T2

<400>  1253
atgggcccca agaagaagag aaaggtaggc agcggcatga gcaattccaa gtaccagttt       60

ctgaacggca agaagctggc cgagttccac atgctgaagc tgtatcctag ctccgccctg      120

aacagagacg atgccggcga gcagaagacc ggcatgtata atggcacact gaggaacaga      180

atctctagcc agtgcatcaa gcggtcttgg agactgagcg agacctttga ggacgtgttc      240

gatgagatcg gcatcaggac aaagcgcatg ccagagtacg tgggcaagaa gctggtggag      300

aatggcgtgc ccgaggagga tgtgatctct tttaagaaga tcctgagcgg cgagaaggtg      360

gacgagaagt cctctaagaa gtccaaggcc gaccaggcca tcgatgaggg caagcctgtg      420

aagaccgccg ccctgagctt ctactccgtg gaggagctgg ataagatcgc cgagatctgc      480

aagaggatct atgacgatct ggaggagcca aagtccaaga atctgaagac aatcaagatc      540

gacaacatcc agaaggagat gcgcaagtgc gtgcacccca tgaatatcga tgtggccgcc      600

tttggcagga tggtgaccga caacatgctg aggcctgtgg agggagcaat gcaggtggcc      660

caggccctgt ctacaaatgc cgccgtgaag gagaacgatt atttcgtggc ctgcgacgat      720

ctggtgaagg gagagaccat cgaggacgtg ggaggagaga tgctgggcga catcgattac      780

aatagcgcct gctactatat ccacgccaac gccgatctgg agcagtttgc cgagaatctg      840

aaggactgtg agaacatgga ggagatcgtg aaggccctgc catctaatat ggtggaagtg      900

atggcctaca ccgaccccac agccaggcag agcaccatgg aggcccacgt gctgcccgaa      960

gtgatctacg tggagctgaa gagcaagaag cggccactga acagaatgaa ggccttcgcc     1020

gagccctgta accgcaatat cgccgagaag tccgccaaga agctggccga ttacatcaat     1080

tgcaccaacg agaaggccga cctgggcatc acaaatgccc tgtggtattg tgaggatgag     1140

agcgtgaagg ccccagagaa tgtgaccgtg gtgaactcca tcaaggagct ggagcagaag     1200

ctgaatgagt ggatgaacga gggctccggc gagggaaggg gctctctgct gacatgcggc     1260

gacgtggagg agaaccctgg acctccgaaa aaaaagcgga aagtgggctc cggcatgatc     1320

caggaggcct acgagaagct ggcccacgag gagaagcggc tgtttgccca ctgtgccggc     1380

aagctgatca aggacgcccc aaaggccatc atccccttct acaaggtggt gccctccgag     1440

atcgagtcta aaaacggcaa gaagtatacc gtggacgagg atgccttctt tgccgccctg     1500

tgcgtgaggt gtctgtttga gaagatcgag ggcgtgacac tggagcccga tatcctgatc     1560

agcgagggcc gcaagaatcc taagatctcc ctggagggct atgaccggag aatcagcgcc     1620

ctgatgtcca acaccgaggc cgagttcttt atccctaagc tggccaagct gatgaattac     1680

accctgaaga tcacatccaa caagatccca gactgcgatc agctgtattg ggatatccac     1740

aatatcggct ctaacgagaa ggacgtgcag aggcgctggg caaggaccat ctacgtgaac     1800

aatgaggagg gcagcggcga gggaagaggc tccctgctga catgtggcga tgtggaagaa     1860

aaccctggac ctccaaagaa gaaaagaaaa gtcggcagcg gcatgaagat caagatcgtg     1920

ctggagggag cattccaggc ctggggagtg ccttccgagt atacctggcg gggcacatct     1980

tactatccaa ccgccagagg catcgtgggc ctgatcggct gctgtatggg catccctagg     2040

ggcgacgatc gcctggagca gctgctgtcc gtgctgaaga tcacctacga catcaacgag     2100

gacgataacg gcaatcggaa gtctggcagc atcctgacag attttcaggt ggtgagaaag     2160

gaggacggag gcaagctgaa tgcagcaaac ggaggaaccg gcgatagcta cggcatcatc     2220

ctgcacaagt cttatatcaa tgacgccagc ttcacagtgc acatcgaggg ccctgacgat     2280

ctgatgaagg acgtgtacga tgccatgctg gaccccgtgt gggtgcctta tctgggcaga     2340

aagaattgcc ctccaaccga gccactgatc cccgagattg aaggctccgg cgaaggcaga     2400

ggctctctgc tgacctgtgg cgacgtggaa gaaaaccctg gacctcctaa aaagaaacga     2460

aaggtaggct ccggcatgta cctgaccaag ctggagctga atatccagaa caaggccgtg     2520

ctgcacaata tgtctaactg cgagtggatg cacaagctga tcctggagaa gggctttggc     2580

cacatccagg ccgagaatgc ccggcagaca ctgaagatcc tgtacgccgt ggatggcatc     2640

aaggtgtatg tgcagtccgc cgtggagccc aagttcgaga actgttctta ctggatcagc     2700

acccctgcca caatctgcat cgacgccatg aagaagatct gtggcaccgg catggccgtg     2760

cactttaagt gcacctgtaa ccccacaaag aagctgatcg atggcggcaa gagaatcttc     2820

ctgagctccg agcgggagag agacgagtgg atcaagagag tgatggagag aagcggcgcc     2880

gaggtgctgg tggagtctca gaccagcgat ttcacagtgt ggggcatgaa gaaggacaag     2940

aagaccgata agtcccacaa gatctacgcc aaggccgtga cctattctgg cgccctgaag     3000

atcacagacg aggagaagtt ttgggaggcc ttctgcaatg gcatcggccg ggagaaggcc     3060

tacggctgtg gcatgctgat gatccaagtc ggcagcggcg aagggagggg ctccctgctg     3120

acctgcggcg acgtggaaga aaaccctgga cctcccaaga aaaagaggaa agtgggtggc     3180

agccagctgg tgaagtccga gctggaggag aagaagtccg agctgagaca caagctgaag     3240

tacgtgcctc acgagtatat cgagctgatc gagatcgccc ggaacccaac ccaggataga     3300

atcctggaga tgaaagtgat ggagttcttt atgaaggtgt acggctatag gggagagcac     3360

ctgggaggca gccggaagcc tgacggcgcc atctacaccg tgggcagccc aatcgattat     3420

ggcgtgatcg tggacacaaa ggcctacagc ggcggctata atctgcctat cggccaggcc     3480

gacgagatgc agaggtacgt ggaggagaat cagacccgca acaagcacat caaccctaat     3540

gagtggtgga aggtgtatcc atctagcgtg acagagttca agtttctgtt cgtgagcggc     3600

cacttcaagg gcaattacaa ggcccagctg accagactga accacatcac aaactgcaat     3660

ggagccgtgc tgtccgtgga ggagctgctg atcggcggcg agatgatcaa ggcaggcacc     3720

ctgacactgg aggaggtgcg gagaaagttt aacaatggcg agatcaactt ctctgctagc     3780

gagacacctg gcacctccga gtctgccacc ccagagtccg gcggctctgg ctctagcggc     3840

ggctctggct cctccggagg aatgtgcgat cagcagtacg tgtctacact gaatgtgctg     3900

aaggaccctt ggattcccgt ggtgtttctg gacggcaaga tcaaggatgt gggcatcatc     3960

gagtgtttca gaaacgccga gaagatcaag accatctcta acagcaagcc atatgagaag     4020

atcgccatcc tgagatttct gaccgccttc atcacagacg tgtaccagct ggataggcgc     4080

atcgagaggc agaagctgta tgacgccggc tctttcgaga tcgagcgcat cgagaattac     4140

gtgaaggagt gcgaggagaa gaacggcgcc agctttgtgc tgggcgatag ccagcggtcc     4200

ttcttttgtt tcaactacaa tccccaggtg gacaccgagg gagtgaagct gagcgccgcc     4260

tatctgcacc tggagctgcc tcacggcaac aatccaatcc acatcgtggc ccagagggag     4320

gaggactttg agggcgatac actgccacag ttcctgaggg ccgccctggc ctttaatctg     4380

ttccctaccg gcaacatgct gaagggcgcc aattctaaga caggcgacaa ctgctacatc     4440

gatggcgtgg gcaaggacgg caagcctaag tacaccgccg cctatggcag catgggcatc     4500

aatgcaggct ctagcatggc agcagcagag cccgtgttct tttggcctga gtgcgataac     4560

ctgtttcaca cactggtcat gtgcatgagg tcccagggcg agctgcagaa caatctgaag     4620

ctgaacgatc ctccagcctt ctggaatgca gacgcagagc caaaccctaa ggcaggcaag     4680

aggggcgaca tcgtgaccag cgtgagcttc gtgagcggcc tggcattcca ggcaaggaga     4740

atcgtgccag tgatcgagaa tggcaaggtg tacgagtgtt atatctctaa cggctacaca     4800

aacagcaatg agaacgtgtg gcacgatcca tttgccgtga ggctgcgcaa ccacaagtcc     4860

ggcgagatct tccagatgcc agcaaagggc gacagggaga tgtggcgcaa tatcggcaac     4920

ctgaccgcct ccagggagga gtcttggcac ctgatgccag atgtgctgcg ccccatcaag     4980

aagagcgccg acgccacaga ttactatgag aatatctcct ctctggccat gatcccaatg     5040

acccagaacg ccggctacag cgccatgttc tatgacgata cagtgcagat ccccaaggag     5100

tacctggagg attcctacct gggcgagtat ctgaccacaa ggatggagat cgtggaggag     5160

atctctaaga tgtgggacaa gctgaagatc agcgccctgc tggacaataa ggataagttt     5220

tccggccact acagggacga tgccctgcag gagtattggg tgaagatcca ccagtttctg     5280

ttcgacggcg acgattcttt cctgaaccac gtgatcagaa tgtaccacga ggatagctcc     5340

tcttttgaga agaccgccga caaggccctg ttcgagtatc tgacaaagag cgtgaaggag     5400

atctgcgaga aggaggagaa gaataccaac tcctggaata tgctggtgaa gatcatccgc     5460

cagatccacg gcaagaacgg ctgtctgcac atcttctacg gcaccctgaa gaagtattgg     5520

aagaaggagg gcaaggacaa gaacgataca ggcagcatct ga                        5562


<210>  1254
<211>  5565
<212>  DNA
<213>  Klebsiella pneumoniae strain VRCO0172

<400>  1254
atgggcccca agaagaagag aaaggtaggc tctggcatga ccacaccctt ccgcaacacc       60

cggatcgagt ttcacatcct gcagagcttc cctgtgacat gcctgaatag agacgatgtg      120

ggagcaccaa agtctgccat cgtgggaggc gtgagccggg ccagagtgag ctcccagtgt      180

tggaagagac aggtgaggct ggccctgcct gactttggca tcagactggg cgtgaggtct      240

aagaagaccg ccagcctgct ggcaaacgcc tgccgggccc tgggagccag cgaggagcag      300

gccaccggct gtggcgaggc catggccgcc ttcttttctg acgatacact gctgtttctg      360

agcgaggcag aggcagcagc cttcgccgcc tacgcccagg gcaaggattt tgacgccgcc      420

agcctgaagg acaaggagct ggtgaaggtg gccaagaagg tggtgaacaa taccctggat      480

gccctggaca tcgccctgtt cggcagaatg gtggccaagg cagcagatat gaacgtggag      540

gcagcagcct cctttgccca cgcaatctcc acacacaagg tgtctaatga gatcgagttc      600

tttaccgccg tggacgattg caagacagag gacgagtccg gctctgccca catgggcagc      660

ctggagttca actccgccac ctactataga tacgtgtccc tggatctggg acagctggca      720

cagaccctgg gagaggatgc cgacatgaag acagccgtgg ccgcctttgt gaaggccctg      780

tacgtggcag tgccatccgc cagacagacc acacagtctg gcgcctgtcc ttgggagtat      840

gcccgcgtgc tgctgcggaa gggacaggga ctgcaggcca gcttcgagca gcctgtgaag      900

tcccagggcg agggctttct gagcccatcc aaggccgccc tgaagaattg gctgcacacc      960

aaggagaagc tgtctggcag cctgttcggc aagcagggcg actacgagtg gggcgaggat     1020

ctggactata gcatcgatcg cctgatcgca gacctgcagt cccacctggg ctctggcgag     1080

ggaaggggct ccctgctgac ctgcggcgat gtggaggaga accctggacc tccgaaaaaa     1140

aagcggaaag tgggcagcgg catggatcag gtgcctgcag acgtgacagc agagtctgcc     1200

ggcaatgaga gcccagccaa gcggttcgtg ggctatgtga tcgagcggat cgccaaggat     1260

aacggatttg cagcacgcct gaagagggca gacaatccag ccaccgagta tcagtcctgg     1320

gagatcctgg ccggcttcgg catcgacctg gagaaggagt ggcagcgcct gccatactgc     1380

gtgatcggag ccgccctggc aaaggcaaag cctgcctcta acggaaccat cacactggga     1440

gcagcaatcg caggatgtta ccccgagggc aatcagagcg agcaggcaaa ggcaaggctg     1500

cggagactgc tggcatgcac ctccacatct gaggcctgta gaatcctgag gccactgctg     1560

gccctgatgg caagccgctc cgtgaccccc gacttcgcag gactgctgaa cgagctgcag     1620

tggtttagcg gctctagcag ggagcgcatc cgggcaagat gggcacagga gttttatagg     1680

agggcaggag aggcagcagg ctctgaggcc agaaacagcc acgacggctc cggcgaggga     1740

aggggcagcc tgctgacatg tggcgatgtg gaggagaacc ctggacctcc aaagaagaaa     1800

agaaaagtcg gcagcggcat gaggcagacc acacagtaca tgctgctgtg gctggaggga     1860

ccactgcagt cctggggagg cgactctaag tttggcgtga gagataccct gaatttccct     1920

acaaggtccg gcatcctggg cctgatctgc tgtgcaaggg gagcagcagg ccctgaggtg     1980

gagtggctgg ccgagatgaa caatctgcca atggaggtga gagcctatgc caggaccgac     2040

aaggagggac agcctctgct gagggagcca acactgtgcg atttccagat ggtgggcagc     2100

ggctacgacg attccgaccc ctggcagtct ctgctgatcc ctaagaccag cgatggcaag     2160

aaggcagtgg gaggaggaac caagatgaca tacaggcact atctgcagga tgccgtgttt     2220

gcagtggtca tgggactggg cagccagcag gcagagtccc tgcctgaggc cctgcagaac     2280

ccagtgtggg acctgtacct gggccggaag tcttgcgtgc ctagcgagct gatctaccag     2340

ggcatctatg attccgccga ggcagcatgg cagcaggcaa gaaccctggc cgagagcaag     2400

cggagaacac tgtcctataa agtgatcgag ggcgagggcg atggcgacgt gatcaccctg     2460

aacgacgtgc ctgtgcagtt cggccgccac aagaggtacc gcgataggca ggtcaccgtg     2520

ctggagtgcg gaggctctgg cgaaggcaga ggcagcctgc tgacctgtgg cgacgtggag     2580

gagaatccag gaccccctaa aaagaaacga aaggtaggct ccggcatgac cgatctgttt     2640

gcatctgccc tgcacctgga cagggcagca gtgaaggccc tgaagatctc cgatgcctac     2700

tctctgcacc gggtggtgta tagcctgttc gcagatgcaa ggacagacag ggagaagtgc     2760

tcccacatct cctctggcat cgcatacgca gatcagggag gcgactttca cggacgcaag     2820

atcctgatcg tgagcgacag gctgccagca gcaaaggtgg atggactgta cggcgaagtg     2880

atctctaaga gcatccctgc cgcctttctg tcccacagcc ggtataggtt ccaggtgcaa     2940

gtgaatccag tgaggaagga caagcagacc ggcaagagag tggccgtgaa gggcagggcc     3000

gatatcgcac agtggttcat ccagagggca gcatcccggt ggggctttga tgtggacctg     3060

ccaggactgc aggtggaggc aatggaggtg ctgcagttca aggacaaggg aggccgccag     3120

gtgaccctgg gcaaggcaac agtgcaggga ctgctgaccg tgacagatag acagaagttt     3180

cagcactctt tccaccacgg aatcggcaag ggaagggcct tcggctgcgg actgctgcag     3240

atcgtgccag tggtggacgc cctgtttagc ggctccggcg aaggcagggg cagcctgctg     3300

acttgcggcg atgtggaaga aaaccctgga cctcccaaga aaaagaggaa agtgggtggc     3360

tctcagctgg tgaagagcga gctggaggag aagaagtccg agctgcgcca caagctgaag     3420

tacgtgccac acgagtatat cgagctgatc gagatcgccc gcaatcccac acaggacaga     3480

atcctggaga tgaaagtgat ggagttcttt atgaaggtgt acggctatag aggagagcac     3540

ctgggaggct ccaggaagcc agatggagcc atctacaccg tgggctctcc catcgattat     3600

ggcgtgatcg tggacacaaa ggcctacagc ggcggctata acctgccaat cggacaggca     3660

gacgagatgc agcggtacgt ggaggagaac cagacccgga ataagcacat caacccaaat     3720

gagtggtgga aggtgtatcc cagctccgtg acagagttca agtttctgtt cgtgtccggc     3780

cacttcaagg gcaactacaa ggcccagctg accaggctga atcacatcac aaactgcaat     3840

ggcgccgtgc tgtctgtgga ggagctgctg atcggcggcg agatgatcaa ggccggcacc     3900

ctgacactgg aggaggtgag gcgcaagttt aacaatggcg agatcaactt ctctgctagc     3960

gagacacctg gcacctccga gtctgccacc ccagagtccg gcggctctgg ctctagcggc     4020

ggctctggct cctccggagg aatggagaac aggttcaatc tgatcgacga gccctggatc     4080

gccgtggtgg atgtgggcct ggtgtccctg accgacatct tttctcagcc agagctgcgc     4140

gccctgggag gaaatcctgt ggagaagatc gccctgacaa agctgctgct ggcaatcgca     4200

caggcagcag caacccctac agacgattcc gactggcagc agatgggatg gcagggaatg     4260

gcacactgct gtctgcagta cctggccaag tggcacgatc ggttctacct gtatggcgag     4320

aagcccttcc tgcagatgcc tgccatccag gcagcagagt gcaagtccct gggcgtgctg     4380

agccctgagg tgtccaccgg caacaccaca gtgctgacag agtctcagca gcagcagcag     4440

ctgaccgatg ccgacaaggc cctggccatc gtgatgcaga tgggcttcgg cctgggcggc     4500

aagaagaccg acaacagcgt ggtgctgaca cccggctatc ggggcaagca gaatgataag     4560

ggcaagcctg gcagcggcaa ggcaggcgtg tccgtgggac acatgggcct gctgcactcc     4620

ttctggcagg gcaactctat cgtgcagagc atctggctga atctgtttac cgccgaggac     4680

atcacacagc tggccatgta cccaaccctg ggcacagccc catgggagag aatgcccacc     4740

ggcgaggacg atgacatcgc cagatccctg aaggcctctc tgctgggcag gctgatcctg     4800

atgggcaagt tctgtctgct ggccgaggat ggcatccact acagcgacgg catctcccac     4860

gccggctatc tggagggcaa gaccgatccc agcgtgtccg tggacttcag cggcaagaag     4920

cctaaggccc tgtgggtgaa tccaggcaag agaccctgga gggagctgac atctctgctg     4980

cagtttatcg agcaggacag cccacgcggc tatgagaccc ggcagctgag cctgcccctg     5040

aagagaatca cacaccacgc agagcagttt gcactgtggt ccggcggact gagggtgagc     5100

tccaacgcag gagagcagta cgccagcggc accgatgact atgtgcagtc cgagatctgg     5160

ctgtctagcg acctgatcaa tcacaccttc ctggagtacc tgaagtatga gatgacacag     5220

ctggatgcag tgcagaagca gctgtgggga gcagtggtgc gctactttcg gcagctgtcc     5280

gatatcgaca agtctgccac aggcaaggca cagcccttcg tggcaaagca ggcagagaag     5340

gccaccacaa tcttttggca gctgtgcgag aggcaggcac agaccctgat caacgcctgt     5400

ctgaatagcg gcgaggacca cacagccaga ctgcagctga ggaagatctt tgccagatat     5460

gccggccagg tgttcgatca gctgtgccct gccgactccg ccaggcagct ggatgcctgg     5520

gcactggccc ggccaaactt ctctcagtac ctgaccctgg attga                     5565


<210>  1255
<211>  5769
<212>  DNA
<213>  Streptococcus thermophilus strain ND07

<400>  1255
atgggcccca agaagaagag aaaggtaggc agcggcatga ccacagagca gagactgttt       60

ctggacatcc acgccatcca gagcctgccc ccttccaaca tgaatcggga cgataccggc      120

tcccctaaga cagcccagta tggcggcgtg cggagatcta gggtgagctc ccaggcctgg      180

aagaaggcca tgcgcgagta cttcaacacc cacggcgatc acagcaatgt gggcatcagg      240

acaaaggaga tcgtgcgcta tgtggccgac aagatcgtgg agctggattc tagcatctcc      300

atcgaggacg ccctggagaa ggccgataag gtgctgatcg ccgccggcat caagaagaag      360

ggcgaggtga aggccctgta cttcatgggc gattcccagg ccaagaagct ggcacaggca      420

gcatacgaca acatcaccca caagaaggag ctgcagaagc tggccaatga ggaccccgcc      480

atcgatatcg ccctgttcgg aaggatggtg gcagaggacc ctaccctgaa cgaggattcc      540

tctagccagg tggcacacgc aatcagcacc cacccagtgc agacagagtt tgatttcttt      600

accgcagtgg acgatctggc ccccgaggac aatgcaggag caggaatgct gggaaccgtg      660

gagttcaact cctctacact gtaccggtat gccaatgtgg ccatccacga gctgtctaag      720

cagctgggca acaaggagag cctggagaat tctctgagcc tgtttatcga ggccttcgcc      780

aagtccctgc ctaccggcaa ggtgaacaca tttgccaatc agacactgcc acagaccctg      840

atcgtgacag tgaggtccga ccgcccagtg aacctggtgt ctgccttcga ggagcccgtg      900

aagagcatcg agggctatgt gaccaagtcc atcgataagc tggccaagga gtttatcaag      960

gtggagaagt tcgtggacaa gcccctgatg accttttacg tgacactgca cgagtccgat     1020

tctctgaagc agatcggcga ggagaaggat agcgtgtcca agctgctgga ggacttcagc     1080

gagatgatcg cacagtacat cggctctggc gagggaaggg gcagcctgct gacctgcggc     1140

gacgtggagg agaaccctgg acctccgaaa aaaaagcgga aagtgggctc cggcatgtct     1200

cagcacacca agcagacagt gtggaccgtg acaaagaaga tcatcttcaa gctgtccaat     1260

cagaaggagg agacctacga taaggccaca ctggccaagg tgcgcaagac cctgggcaag     1320

cctctgtctg aggccacaga gatctggcct atcctgtttg agaacctgcc agaggagttc     1380

ctgagctcct accagcagcc atcctatgag gagctggcca tctacaccgc cctgcagctg     1440

tatgccctgc accagcaggg cgtgtctaca agcgtgatgc tggacgattc taagccttat     1500

gagaacatcg gcagcgccct gggcaagctg cgcaaggagg acgataccac aagcatcgac     1560

aggcgcttta ataccatgat cacatctagc accttcgagg agctgaccta ccacctgcgg     1620

cacctgatct ccctgctgaa ggtggagtct ccagtgatcc aggtggacta ctccggcctg     1680

gccaacgatc tgtattggtt cctgaacaat tctcaggaga acgtgaggct gaattgggcc     1740

cgcgcctact ataagcagat caagggcgag aagaacaatg acaacggcag cggcgaggga     1800

aggggctccc tgctgacctg tggcgatgtg gaggagaacc ctggacctcc aaagaagaaa     1860

agaaaagtcg gcagcggcat gaagaccatc ctgctgaagt ttgcaggacc tctgcagtcc     1920

tggggcacat cctctcactt tgagacaaga cacaccgact tctatccatc caagtctgcc     1980

gtgatcggac tgctggcagc cagcctggga taccggagag acgaggatga gaagatccag     2040

aagctgaatg agctggactt cgccgtgcgg gtggatcagc agggcaacct gctgagagac     2100

tttcacgtgg cccagaagta caccgagaag ggcaagttcg atcggaacta tgtgacaaat     2160

agatactatc tggaggacgc cgtgtttgtg gtggccctgt cccacaccga cgattctttc     2220

atcgatatca tcaagggcgc cctgaagaac ccctactttc agcctttcat gggcaggcgc     2280

gccctgccta tcaccgcaga ctttatcctg ggcgagacag atgtgaatcc actggagagc     2340

ctgaagtccc tgaagtggca ggcctctctg tggttcatga agaagagcca cgacaaggat     2400

gccatctccc tggaggtgta cctggactct cagctggtga acaaggacgt gtaccagctg     2460

cggcaggact acgtgcggag cttcagccag aagggccgga gattcggctt taggtacgag     2520

gtgcgcgagc tgatctccgt gcagaaccct cactatctga acaagaatac cgagcacaat     2580

atcttcgaga gcatcggcga cggctccggc gaaggcaggg gcagcctgct gacatgcggc     2640

gatgtggagg agaaccctgg acctcctaaa aagaaacgaa aggtaggctc tggcatgtac     2700

atcagcaggg tggagatcga tcgctataat aggaggaagg tgcgcgacct gacccacgtg     2760

ggagcatatc acgcctgggt ggaggagtct tttccaagcg agctggagca gtctatcagg     2820

acacgcaagc tgtggcggat cgacagaatc cagggcaagg attacctgat catcgtgagc     2880

aaggagaagc ccaatctgca gaagctggag aagtacggag tggtgggcag cgcccagact     2940

aaggactatc agcacttcct ggattccatc aagacaggct ttcggatgaa cttcagaatc     3000

gtgctgaatc ccgtgatctc catcacctct cctgacaaga gcaagcgggg cgtggtgaag     3060

ccccacgtga caatcaagca ccagatggat tttctggtga agcagtctga gaagaacggc     3120

tttagcctgg tgggcgagtc tttcagcatc gtggagaggg gctatgaggt gttccagaag     3180

cctgagaagc caatccgcct gtctaaggtg gtgtacgagg gcaccctgac agtgagcgac     3240

gataccctgt ttaagaagat gctgacagag ggcgtgggca agaagaaggc ctacggcttc     3300

ggcctgatga ccgtggtgcc cctggaggag ggctccggcg agggcagggg ctctctgctg     3360

acatgtggcg acgtggaaga gaaccctgga cctcccaaga aaaagaggaa agtgggtggc     3420

tcccagctgg tgaagtctga gctggaggag aagaagtccg agctgcggca caagctgaag     3480

tacgtgcccc acgagtatat cgagctgatc gagatcgcca ggaaccctac ccaggaccgc     3540

atcctggaga tgaaagtgat ggagttcttt atgaaggtgt acggctatag gggagagcac     3600

ctgggaggca gccggaagcc tgatggagcc atctacaccg tgggcagccc aatcgactat     3660

ggcgtgatcg tggatacaaa ggcctacagc ggcggctata acctgcccat cggccaggcc     3720

gacgagatgc agaggtacgt ggaggagaac cagacccgca ataagcacat caaccctaat     3780

gagtggtgga aggtgtatcc aagctccgtg acagagttca agtttctgtt cgtgtctggc     3840

cacttcaagg gcaactacaa ggcccagctg accagactga atcacatcac aaactgtaat     3900

ggagccgtgc tgagcgtgga ggagctgctg atcggcggcg agatgatcaa ggcaggcacc     3960

ctgacactgg aggaggtgcg gagaaagttt aacaatggcg agatcaactt ctctgctagc     4020

gagacacctg gcacctccga gtctgccacc ccagagtccg gcggctctgg ctctagcggc     4080

ggctctggct cctccggagg aatgtccagg ttcaacctgc tggatgagcc atggatctcc     4140

gtgatctatg acgagaaggg cagcaccaag gacgtgtccc tgcaggatct gtttacaaat     4200

gcccaccagt acaaggagct ggccggcgac accaagacac aggatttcgc cgtgctgcgg     4260

gtgctgctgg ccgtgctgca caccgtgttt agcagattcg acatcgatgg caacgcctac     4320

gagtatctga caatcgacga gggctggaat cagctggagc ctgtggacga gatggatatc     4380

gagaactacg aggaggccct gtatgagacc tgggagaagc tgtggacaaa taagcggttc     4440

ccaaacatcg tgaatcagta cctggagaag tggcgggacc ggttctacct gttcgatcag     4500

aagtatccct tctttcaggt gaccaaggag gacatcgccg gcgataagat cagcaaggcc     4560

aagggcacat ccatcctggg caagaacatc aatagaatca tctctgagag cggcaacaag     4620

atcgccctgt tctccccaaa ggacgaggag aacaagaata ccctgacagc agcagagctg     4680

gcaaggtggc tgatcacctt tcagggctac tctggcgtga gcgacaaagt gatcttcggc     4740

aacgagaagt atacacccag caagggctgg ctgtttgata tcggcgccat ctacatcaag     4800

ggcaataccc tgttcgagac actgctgctg aactacatct ccccatataa tgagtgcggc     4860

aacgtggaga atatccagcg gccctgttgg gagagaaaga gctccgatat catcaagtct     4920

tacctggacg agaaggatat caccaatatc gcctctctgt acacagtgtg gagcaagggc     4980

atctatatcg accccgactt caacctgaat aagccctttt ccttcgacat cgtgaagctg     5040

ccagacatca accacaggga taatttcctg gagcccatga ccctgtggaa gtacaacgtg     5100

tccggcaaga atcgcgattc ttatacaccc aagaagcacc tgctgaacca gtctctgtgg     5160

aggagctttg gcctgctgag catcaaggac accgatctgc agcaccgcaa gcctggcgtg     5220

atcgagtggc tgacatacat cgacgatatc atcggcaacc ggctgagcaa tatcgtggcc     5280

atctccatgc aggacgatgg caatccacag agcagactgc ccaccgacga agtgatcgat     5340

tccatcttca tcaacgacct ggtgctgaca gacctggatg agggcggctg ggtgcccaga     5400

atcaatgagg tggtggagga gaccaagaag atcatctccc ggacatacaa gacctatatc     5460

aacgatatca aggagatcag aaacatctcc aatggctctt acacccagca gatcgtggag     5520

agcctgtact tcaagatcga ccagcccttc agacagtggc tggcctccat ccagcctgag     5580

gacgataagg attctaagat ccaggagtgg agggtgctgc tgaagaagat cgtgaaggcc     5640

gaggcagaag tgatcctgca ccagggagga gccagggatt atctgggcat ccagaaggac     5700

ggccgcatca agaacatcgc caccgcctac aatagctttg acttctggct gaggcagcag     5760

ctgaagtga                                                             5769


<210>  1256
<211>  6294
<212>  DNA
<213>  Streptomyces sp. S4

<400>  1256
atgggcccca agaagaagag aaaggtaggc agcggcatgt cccagccagc agcaaggcca       60

cctagaacat acgtggactt tcacatcctg cagaccgtgc cacccgccaa cctgaatcgg      120

gacgatcagg gcaacccaaa ggaggcctac tatggcggcg tgcggagatc cagagtgagc      180

tcccaggcct ggaagagggc aacccgcaca cacttcgcag agcgggtgcc cgagcaggat      240

ctggcaacca gaacaaggag gatcatcggc gccctggcag acgatatcca gaagagggcc      300

ggcctggata ggcctgccgc cctgaggctg gcagacgccc tgctggcccc actggagctg      360

tccggcggca agaagaagga cgagtctgcc tacctgctgt tttatggccg gagacagctg      420

gatgcagtgg ccgccctggt ggcagaccag gcaaccgagc tgtctgccct gagcgatgca      480

gacctggcat cccgggtgaa ggagctgccc gtgagagagc agttttctac aggccaccct      540

atcgacgtgg ccctgttcgg caggatggtg gccgacatcc ctgccctgaa ggtggatgca      600

gcagcacagg tggcacacgc cctgagcaca cacgccgtgg agctggagtt tgattacttc      660

accgccgtgg acgatgagca gacagacgag gagaccggag caggaatgat cggaaccatc      720

ggcttcaaca gcgccacact gtaccgctat gcctccgtgg gactgcacca gctgctggac      780

aatctgaccg atgaggaggc cgccctgaca gccatctccg agtttgccac ctccttcgcc      840

cggtctatgc ccacaggcta tcagaactct tttgcccaca ggaccctgcc cagcctggtg      900

gcagtggtgg tgcgcgagga ccagcctgtg aatctggtga gcgccttcga gcagccagtg      960

gccacaccat ccggcatcgc agcagcatct gccgcaaggc tggccgagga gcacacccgc     1020

gcaaccgtga catggggcga tgcaccagcc tttgccgcag caacacacgt gttcaccgac     1080

caccagaaga ccacagccgc cctgaacagc gcctttggcc ctagcatccc attctccgcc     1140

ctgctggagg gactgcacac ccacctggca ggcgccctga agcctaagca ggcagcacag     1200

ggcagcggcg agggaagggg ctccctgctg acctgcggcg acgtggagga gaaccctgga     1260

cctccgaaaa aaaagcggaa agtgggctcc ggcatgtcca catctccact gtctgccccc     1320

gtgcctggcc agagagtgtc tagcctgcca aggccatact ggtccggcag ggcagatgag     1380

cagggacagt ggcggaccag agcaggagag agcctgaggc cacctggaga ggacctgtcc     1440

gccctgagag caggactggg caagaaggcc ttcacagagc caaggctgtg gcagtactat     1500

accacaccca cagatggccg cgtgaccctg gagctggagg cagagcacgc cgccctggcc     1560

ctgtacggac tgcaccagca gagccaggag cagccaatgc acaggcaggg cgtgcggacc     1620

ggaagagccc tgagggccct gcaccagcgg tactctgagg aggcaacaga caggcgcgtg     1680

gcacaggcag tgggagccac cagcgccgca gcctttgcct ataggctgcg cgccctggtg     1740

acccagctga ggtctatcgg ccagccactg gattacgacc agctgatgca ggatctgctg     1800

aggtggcact tccccgacgg ccggagcaga gtgcggagag gatggggact gggataccac     1860

ggaagggaca ggcagcccga tgaggcccca ccccctgagg gcagcggctc cggcgaaggc     1920

agaggctccc tgctgacttg tggcgacgtg gaagagaacc ctggacctcc aaagaagaaa     1980

agaaaagtcg gctctggcat gaccacagca cctacaccag agccagcagg aaatacccac     2040

ccagcacacg gctccgatga gcctaccgtg ctgctgctga ggctggcagg accactgcag     2100

tcttggggcg tgagatcctc ttttaacagg agggacacag gagcagagcc aaccaagtcc     2160

ggcgtgatcg gactgctggc agcagcagca ggacacccta gagagcagcc actgggagag     2220

ctggcagatc tgaccctggg catcagggtg gaccagccag gcacactgct gagggactac     2280

cacaccgtga gcgattatag gggcagacct ctgccacagg caggcgtgtc tgccaagggc     2340

atccagaagc ccaccagccc tgccaagcac acacacgtga ccacaaggtt ttacctgcag     2400

gatgccgtgt tcgtggccgc cctggaggga cctccaggac tgctgaccac actggacagg     2460

gccgtgcgga atccagcatt cccactggcc ctgggccgga gaagctgtcc acctacccag     2520

ccactgtccc tgggactgcg gaccacagat atggagacag ccctgagatc tgagccttgg     2580

caggccagcg cccacaccag agagcagtat gcaaggcgcc tgggaaggga gaggggactg     2640

caccagcctc tgcacccagg aaccatcgac agggcagcaa caatcgagga ccccaggggc     2700

gacgataggc tgcaggacgc acccgtgagc tttgatcctc accagagggc cttcacctcc     2760

agacaggtga ggcacacctg gctggccatc cccacaggct ttgaccacat cgacgatgac     2820

cagcctcacg gacaggcaga tgaccccgat cacgaccctt tcgccctgct gggatggggc     2880

tccggcgagg gcaggggctc tctgctgacc tgcggcgatg tggaggagaa ccctggacct     2940

cctaaaaaga aacgaaaggt aggcagcggc atgacatacc tgtcccggat cagaatcaac     3000

ccactgcgga aggacagccg gaagctgctg agcaatccaa gggcagtgca cggagccgtg     3060

atgggaggcc tgccaaacca caagcccgat gacagggtgc tgtggcgcat ggaccccgac     3120

aatcctcaca ggccacacct gtttgtgctg agccccacac gccctgactg gacccacatc     3180

atccaggatt gtggctggcc agatgcagac ggcgatcacg cagccgtgag agactatacc     3240

ccactgctga gccagctggc agtgggaaga gagttcgcct ttaggctgac agcctccccc     3300

gtgcagaaca ccgccacacc aaccaaggca accccagcac aggcagcaag gctgaccaca     3360

cacgccgaga atggcaagcg gatcagaggc ttcagaatgg gacacagaac cgcagcagca     3420

cagctggatt ggtttctgac acgcaccgac cggtggggct tcgatatccc tgcaacaaga     3480

tctgacccag cagcaccagg catccacgca ccaacacctc caaccgcacc aaggcctaca     3540

agcccaccta gaccagatcc caacccacca tacgaggtgc gcatcaccgc aaggcacaga     3600

cactcctttc agaagaatgg ccacggcgcc cacgtggtgt ttcggtctgc caccttcgag     3660

ggcaggctgc gcatcacaga caccgatcgg ttcaccacat ctctgctgac aggcctgggc     3720

cctagcagag cctatggatg cggactgctg acactggcac ctctgccagg acagcagacc     3780

ggctctggcg agggaagggg cagcctgctg acctgtggcg acgtggagga gaaccctgga     3840

cctcccaaga aaaagaggaa agtgggtggc tcccagctgg tgaagtctga gctggaggag     3900

aagaagtccg agctgaggca caagctgaag tacgtgcccc acgagtatat cgagctgatc     3960

gagatcgcca ggaatcctac ccaggatcgc atcctggaga tgaaagtgat ggagttcttt     4020

atgaaggtgt acggctatag gggagagcac ctgggaggca gccgcaagcc agacggcgcc     4080

atctacacag tgggctcccc catcgactat ggcgtgatcg tggataccaa ggcctacagc     4140

ggcggctata acctgccaat cggacaggca gacgagatgc agcggtatgt ggaggagaac     4200

cagaccagaa ataagcacat caacccaaat gagtggtgga aggtgtaccc cagctccgtg     4260

acagagttca agtttctgtt cgtgtccggc cacttcaagg gcaactataa ggcccagctg     4320

acccggctga atcacatcac aaactgcaat ggcgccgtgc tgtctgtgga ggagctgctg     4380

atcggcggcg agatgatcaa ggcaggcaca ctgaccctgg aggaggtgcg gagaaagttt     4440

aacaatggcg agatcaattt ctctgctagc gagacacctg gcacctccga gtctgccacc     4500

ccagagtccg gcggctctgg ctctagcggc ggctctggct cctccggagg aatgcctggc     4560

aagggaggag caagcgtgaa cctgctgtcc gatggctggc tgagcgccgt gtccgccggc     4620

ggcggcagcg gctttggagg aggacctgga gcaggaccag cagagttcgg cgtgcgcgag     4680

ctgctgctga atgccgagaa gtttgccgac atcgtggtgg atctgccaac ccagaggcct     4740

gccgtgttcc ggcaggtgct gctgcctctg gtggtggacg ccctgggatg tccaaaggac     4800

gcagaggcct ggatggatat gtttagggca ggagccttct cccccgagca gaggcaggtg     4860

ctggccgact acctggataa gcaccagcac ctgtttggac tgctggaccc cgtggagcca     4920

ttcggccagg tggccgacct gagaacagca aagggagaga ccaagggcag cgccctgctg     4980

gtggcaacag cagccaccgg caacaatgtg cccctgttta gctcccggac agagggcgac     5040

gtgctggagc tgacccctgc agaggcagca agatggctgc tgcacacaca ctgctgggat     5100

accgcagcca tcaagacagg agcagtgggc gaccctatgg tgaagagcgg caagaccacc     5160

ggaaacccaa caggacctct gggacagctg ggagtgacca tgccagtggg ctccacactg     5220

ttcgagaccc tgctgctgaa tatcccatac ggacaggcag gactgtctga tgacgtgcca     5280

cagtggaggc gccggagcac ccagggcgac gtgaaggata ccctgtcctg tgcaacaccc     5340

gtgtggcaga gccggccagc aaggggactg ctggaggcct ggacatggca ggccagaagg     5400

atcagactga tctcccagga cacagatcgc ggcccaagga tcaccagagt gctggtggca     5460

gcaggcgaca ggctggaggt gtctccagat acagagcccc acaccgcatg ggtggtggat     5520

agcccagcag gccggagagg caagtctcct gcacggagcg gcgtgaagtc cgccagacca     5580

agaaggcaca ccgcaggaag ggcaggatgg aggggcctgg acgccctgct ggccgtgaac     5640

gccgtggacc aggatcagca ggcaacagca acccggagcg gcgccgtgtc tagccagctg     5700

gtgagacagc tgtctgccat cagccgccgg ctgcctagcc ggtacccact gagagtggag     5760

ctgaccggca tcgcctatgg caaccagtcc gccgtgatcg aggacatgta cttcgatgag     5820

atcccactgc ctgtggccgc cctggacccc gagggcatcg tgtacggcgc cctgctggag     5880

gtggtggacc aggccgagga tctggccaag gccgtgaatc acctgtccgg cgacctgaga     5940

agggcagcag gctctgagcc aatcccatgg gacaagggac agaggcctgg cgataccctg     6000

ctgcacgccc tggacccaat cgtgcgccgg ctgctggcag gactgaggca ggccggcgat     6060

gactttgata ggtgtgagca gggcctggag gcctgggagc acaaggcagg acaggccaca     6120

ctgcgggtgg cagagggcct gtttaatagc gccccagccg ccctgttcac cggcagaagg     6180

gtgaagaagg acggcaagga gcaggtgtat cgcctgtcta cagcagaggc cagcttccgc     6240

cggagactgg ccgtgatcct gcacaggcgc gccgccgccc ggaccgccgg ctga           6294


<210>  1257
<211>  5103
<212>  DNA
<213>  Campylobacter fetus subsp. testudinum Sp3

<400>  1257
atgggcccca agaagaagag aaaggtaggc tctggcatga agctggccaa ccgcatctac       60

ggcatcatcg gcatcaagag caccatggcc aattggaacg ccgacttttc tggccgcccc      120

aagagcacag gcaatggcga catcttcgcc agcgataagg ccctgaagta tcctatgaag      180

aagatgtggg agtcctacgg caagaacatc ctgttcgtga agtccctgaa gcagggcaag      240

tctaaggacg gcaacgataa gctggtgcca aataccctgg gcgagcggta tggcctgctg      300

tttggcgata tcaagaaggc caagagcaca aaggaggtgc tgtccaatct gttcaactgc      360

atcgatgtga agaattttgg cgccaccttc ccagaggacg gctacaacct gagcatcaca      420

ggcgccgtgc agatcggcca gggctttaac aagttcggcg acatcaacat cgaggtgcag      480

aatatcctgt cccccttcgc cgatagccgg gccaaggaga agaatgagaa cggagaggac      540

gcctcccagt ctaccctggg cacaaagatc gtgaccgatg aggcccacta cttttatggc      600

ttctgtatca accccctggc ctataatgac tacaaggaga tcctgggcga cgattttggc      660

tataatgagg acgattacgc cgagttcaag aaggccgcca gattctgcgc cacctacttt      720

aatagcaact ccaagtttgg ctgtgagaac gagtttgcca tgttcatcga gacagccgtg      780

gacgcctatc tgcctgatct gagctcctac atggacttca tctgcaagga taagaacagg      840

ctggtgaatc tggagaagat cgagaagatg atcgagtcta gcgatgtgaa gaaggtggag      900

atctactata atcctctgtc cctggacgtg gagaccaagt ttgacaagtt cgatatctat      960

tctggcaaca agatcggcag cggcgaggga aggggctccc tgctgacatg tggcgacgtg     1020

gaggagaacc ctggacctcc taaaaagaaa cgaaaggtag gcagcggcat ggatgtgaag     1080

atctaccagc tgaaggtgtt cctgaagctg aatcagaacg tggacttcat caacagccca     1140

gagtttctgt ccaccaatct gcacaaggcc atgctgggcg atgaggccct gaggtccatc     1200

cacatgcagc ggtacctgaa gccctactct atcggctttc tgtacagcat gaagggcaag     1260

aaggacacat ttgtgagcgg cgaggatatg tacttctatg tgcggtccat cgacgagtct     1320

ttcatcagca agctgagaat ctgcctggag aattctaaga acctgggctt taacgtgtat     1380

ctgagcaagt tcgagaatct ggacatcaag caggtggata ggctgtacac catgagccct     1440

gccacaatcg tgctgaagga gggcgataag accatcccat ggcggagaga gaactccgac     1500

atcacagtgc tgaaggaggc cctgatctct aatctgaaga acaagtacga gtatttcctg     1560

gacaagaaga tcgagatcaa ggacgatatc atcgagctga tcgagatcaa gaccaatcgg     1620

gccttcgcct ttagatataa gaacggcaag atctacgcct ataggtacca gatccacttt     1680

agccagaacc gcctggccca ggagttcgcc aatatcgcca tgatcctggg cgtgggcgtg     1740

aagaataccc tgggcttcgg cttttgcatg aggtccaaca atgcagtggg ctctggcgag     1800

ggaaggggca gcctgctgac ctgcggcgat gtggaggaga accctggacc tccaaagaag     1860

aaaagaaaag tcggctccgg catgaaggcc atcagcttta agctgtccgg caagtttgcc     1920

cacttcaaga agccagacgt gaacgagtac gtgtacttca cctacaacaa tatccccaag     1980

cctacactgc tgggactgct gggagcaatc atcggcctga agggctatgc ccagaagacc     2040

tacaacaata agaaggacaa gaagagcctg ctgaacaatg agaatcggtc caacgagcct     2100

gagttctatg agagactgaa gcacctgaag atctgcatca tcccactggt gaagtacggc     2160

aagttttcta agaagatcca ggtgttcaac aattctgtgg gatatgccag caccgaggag     2220

ggaggaaatc tgatcgtgag ggagcagtgg ctggagaacc ccagctggca gatcctgatc     2280

gaggacgatg gctctgccga gtttgagaca atcagccagt atctgttcga taagaaggcc     2340

aagtttatcc cttacctggg caagaatgac cacttcgccg atatctccga ggtggagaag     2400

atcgacctgg ccgagtccaa gaaggataag atcgtgatca agtctctgtt cctggacaac     2460

ctggccaagc aggtggacga tcccgacgat gagatctctt atctgtttaa cgagttctac     2520

cctatcggct tcaatgagct gatgttttac aagctggaga agaccacctt caccaatcag     2580

atctgtcagg ccatggatgg caagtggtat gagttcaagg acggcaccat ctgcttcttt     2640

ggctccggcg aaggcagggg ctctctgctg acatgtggcg atgtggaaga aaaccctgga     2700

cctcccaaga aaaagaggaa agtgggcggc tcccagctgg tgaagtctga gctggaggag     2760

aagaagagcg agctgaggca caagctgaag tatgtgccac acgagtatat tgagctgatc     2820

gagatcgccc ggaatcccac ccaggataga atcctggaga tgaaagtgat ggagttcttt     2880

atgaaggtgt atggctacag gggcgagcac ctgggaggct ctcgcaagcc agacggagcc     2940

atctataccg tgggcagccc tatcgactac ggcgtgatcg tggatacaaa ggcctattcc     3000

ggcggctaca acctgcctat cggccaggcc gacgagatgc agcggtacgt ggaggagaac     3060

cagaccagaa ataagcacat caatccaaac gagtggtgga aggtgtatcc ctcctctgtg     3120

acagagttca agtttctgtt cgtgtccggc cacttcaagg gcaattacaa ggcccagctg     3180

acccggctga accacatcac aaattgcaac ggcgccgtgc tgtctgtgga ggagctgctg     3240

atcggcggcg agatgatcaa ggccggcacc ctgacactgg aggaggtgag gcgcaagttt     3300

aacaatggcg agatcaactt ctctgctagc gagacacctg gcacctccga gtctgccacc     3360

ccagagtccg gcggctctgg ctctagcggc ggctctggct cctccggagg aatgctgttc     3420

gagctgctgg atgagtttaa gaagcagctg gagaagaaca agcacatcgt gacacagaat     3480

cacatcctga aggatggcgt gtatgcccgc atctccgacg agaagtgtga gatcttctac     3540

gtgaagacca tcacagagaa gatcggcaag accgcccaga agcggacaat cctgtataag     3600

cagaacggcg acatcgccct gaatgacgat atgcagtggt ttgagcaggc cgactacctg     3660

agcttcctgt gggatatgaa caaggccgtg ctgcccaata agaagttcca cagcatcaac     3720

tttctgtccc tgttctttaa gctggaggag tccgagtacg tgaaggagaa tctggaggag     3780

tattttgaca tcttcagaga ttactccgcc tttaacaagg ccaaggataa ggagatcctg     3840

tctttctata tggactacat caaggatgag aataggcaga acctgatcac caattctgtg     3900

gtgctgagca agaagtactt caatgacatc aacgattttg ccgtgcagaa caatttcaag     3960

aagtgctaca tcaagttctt tatcgacaag gatttcgaga tctacgagaa ggagagccag     4020

atctatatcg acctgaagat ctacaattcc aacgagcaca acatcaagta taacaatgag     4080

atcttcggcc tgtctaactt caacatgggc atgaatagca agaagccatt tctggagcac     4140

aagaaccgcc tgttcaagat cccctacgcc atctcccaga aggatgccct ggcctctaag     4200

atgctgtttg actggctggg cagccagaac aagcggatca tcagagactt taattccatc     4260

ttcatctcta agtttaacaa gcagtctaag gccgtggtga gcgacttcga gtacgtgccc     4320

gtggataaga acaagtttaa gttcgacaag ttcaagctga agaacttcat gaacatcgag     4380

aatggcgaga aggagatcct gagctttgac gatttcaagc aggtcatcga tgagcagctg     4440

tatcacaagt gcctgtttgg caacctgtac aatgatgaga tcagggtgag caagcgcatc     4500

tccgaggaca tgcagaatct gctgtatcag acccggtgtt ccatggtgga gtactttgac     4560

aagttcaaca ataacgagtt ctactatgtg atccagaagt actctaacga cttcatcaag     4620

atcgccatgc aggacagcga gttcggccgc ctgaacggca agaagagcat caatctgctg     4680

ctgtccatca aggagatcaa gggcgagaag gtggacatcg atggcatcaa gaatagagtg     4740

atctccgccc tgaccgacga taacgtgaca aagctgtctg gcaatgagta ctattttctg     4800

gtgggcaacc tggccatgta cctggtgagc aagtccaaga cctggaagaa gacattcgcc     4860

ctgaccgatc catatacaaa ggcccggaac accaagaagc tgaagatggc cctgtttatc     4920

gacttcgata gatataacta cgacatcttt ctggagaatg gcatcctgaa gaaggccttc     4980

agcctggccc agaattgtga ggatatcgtg atgtccaata acgaccagca gatggtgctg     5040

atcggcatga tgacaaagaa catcatcaag aagcccggcg agaaggacga gatcagcgag     5100

tga                                                                   5103


<210>  1258
<211>  5319
<212>  DNA
<213>  Odoribacter splanchnicus DSM 20712

<400>  1258
atgggcccca agaagaagag aaaggtaggc tccggcatgt ctaacacctt caagaatcgg       60

gtgtttggct gcgtggtcat caagagcgtg aactccaatt ataacgccga cttctcccac      120

cagccacgca cactgcctga cggcagcgtg tacgccaccg ataaggccct gaagtacaca      180

gtgcggaact atatcgacaa gaattaccct gaggataagg tgttctactt taagtctctg      240

aacggcgaca tgcagccacg cgacctggat cagaattatg cccggttctt tggcgactac      300

cccaaggccg ataagaagga ggccgtgaag gccagaaaag tgatcctggg caacctgctg      360

agctgtctgg atgtgaggct gtttggcggc accttcgcct ctaagacagc caacctgagc      420

atccacggag tggtgcagcc tacccacgga gtgaatagat atgtggaggg catcatctac      480

agcgagcaga tcgcctcccc attcaggaat tctaacgaca attctaccga tagcatgcag      540

accacactgg gcacacagtt caagctgcag gagggccact acgtgcacca ctttagcgtg      600

aacccaggca atctggacga gctgaccgag tttgtggata acggccgcct gacaggcgag      660

gacatcgcaa agctgaagga ggccctgaga tgcggagtga cctactatga tagctcctct      720

aaggccggca cagagaacga ggccctgctg tgggtggagc tgaaggagga gtccaagctg      780

gtgctgccct ctttcgtgga cctgatcgaa gtgaatgccg agcgggagat cgattttgcc      840

aaggtgtcta ccctgctgag caaggagaag atcaagaacg agatctccaa gatcgagctg      900

ttctacaata agggcatcac caaagtgatc cacctgcctg agggcacagt ggagctggag      960

ctgaacggac tgggcagcgg cgagggaaga ggctccctgc tgacctgtgg cgacgtggag     1020

gagaaccctg gacctcctaa aaagaaacga aaggtaggca gcggcatgag gctgaagctg     1080

gtgctgaaga tcgtggaggg cacagtgctg ccctgcaact atatgtacga gctgagctcc     1140

tgtctgtaca aggtgctgaa cgagggcaat cccgtgttca ccgcctggct gcacgataag     1200

ggctattgca aggagaagaa ggcctttaag ctgttcacat tttccaattt ctactttcca     1260

tgtttcagaa tcgagggcga caggatcttt gtgctggccg ataccgccca gctgatcgtg     1320

tctttctacc ccatcgaggc catcgacgcc ttcgtgatgg gcctgtttaa gaaccgccag     1380

ctggaagtgg gcgatcggaa gtccagggtg cgctttgagg tgttcaatct ggagaggcag     1440

gcagagcctg agttcaccag ccggatgttc tttaagacac tgtccccaat gtttatcgag     1500

gagcagctgc ccgagacaag aaaggccatc cacctgtctc ctggcaaccc aaagttcgcc     1560

gagctgctgc acctgaatct gctggacaag tacagagtgt tttatggcca ggagcccgat     1620

cctagctggc cactgaccag gctgcacctg ctgtccgagc caaagcccaa gacaatcgtg     1680

ctgaaggtcg gcacccccga ggagacaaga atgaagggct ataccttcag gtttgagctg     1740

gagggccagc ctgagctgct gagactggga tacgagggag gattcggcag gctgaacagc     1800

cagggctttg gctgcgtgga ggtgctgaag cagggctctg gcgagggaag gggcagcctg     1860

ctgacatgcg gcgacgtgga agagaaccct ggacctccaa agaagaaaag aaaagtcggc     1920

tccggcatga acaatcagcg gctgatctct ttcgacatcc aggccgattt tggcttcttt     1980

aagaagcctg actataacga tggcgtgctg ctgacctaca atatgctgca caagccagcc     2040

ctgctgggca tcctgggagc catcatcggc ctgagaggct acaggaagaa gggcgagtgg     2100

cccgagtact atcagagact ggccgccctg cctgtgggaa tcgagccact ggagggcagg     2160

cacgagaagg gcaacttcca gaagacaatc gtgaagtata ccaatacagt gggctacgcc     2220

aaccaggacg gcaatctgct ggtggaggag tctatgctga tccgccctgc ctaccggtgc     2280

tatctgctgc tgagcgagga gcacccagat caccgcaagc tgtatgagta catccgggag     2340

ggctgggccg agtacatccc ttatctgggc aagaacgagt atccagcctg gtttggcgac     2400

tccttccgcg agtacgcctt taagaccttc gtgcctgaga cagatttccg ggtgtctagc     2460

ctgtttatca aggagggcgt gctgaagggc cagcaggtga aggcctcctt ctcttttagc     2520

ctgaagggca tcgtgaatag aggcagcttc gtgtacttcg agaggctgcc cgtgggcttc     2580

caccctgtgc tgatgcagta cgagctggcc gacttcgcct ttaccgattg gacactgcag     2640

gccgccaccc agatggtgaa cctgtaccag ctggaggagg agggcaagat cgtgcagctg     2700

tttggctccg gcgaaggcag aggctctctg ctgacatgtg gcgacgtgga agaaaaccct     2760

ggacctccca agaaaaagag gaaagtgggc ggcagccagc tggtgaagtc cgagctggag     2820

gagaagaagt ccgagctgcg ccacaagctg aagtatgtgc cccacgagta catcgagctg     2880

atcgagatcg ccagaaaccc tacccaggac agaatcctgg agatgaaagt gatggagttc     2940

tttatgaagg tgtatggata caggggagag cacctgggag gctctcggaa gccagatgga     3000

gccatctata ccgtgggcag ccctatcgac tacggcgtga tcgtggatac aaaggcctac     3060

agcggcggct ataacctgcc aatcggccag gccgatgaga tgcagagata tgtggaggag     3120

aaccagacca ggaataagca catcaacccc aatgagtggt ggaaggtgta cccttcctct     3180

gtgacagagt tcaagtttct gttcgtgagc ggccacttca agggcaacta taaggcccag     3240

ctgacccggc tgaatcacat cacaaactgc aatggagccg tgctgtccgt ggaggagctg     3300

ctgatcggcg gcgagatgat caaggcaggc accctgacac tggaggaggt gcggagaaag     3360

ttcaacaatg gcgagatcaa cttttctgct agcgagacac ctggcacctc cgagtctgcc     3420

accccagagt ccggcggctc tggctctagc ggcggctctg gctcctccgg aggaatgctg     3480

caggagatca acaatttcat gaattctctg ccagcagagc tgaagcaggc aggcctgaag     3540

ccaaaggagg gactgcacgt gctgctgaag atccaggaga aggagggcac ccactttatg     3600

gacgagcagt ccgtgtgccg ggtgtgcctg acccggaagg caacagagtt tgattacccc     3660

ttcctgcagc actgcgcaga gctggcccaa gtgggatggt gcgtgaacac aaataagtgt     3720

ttcgacctgc ctgccaaggg cctgcactct tgcagcccat attgtatcgc cctgaagaga     3780

gagagcctgg agggaggcgg caagtacgca aaggacaaga ccaagatcta tgacaggatc     3840

gatacatact ttgccaacgc cctgagctac gtggaggagg attccgagaa ggagcggatc     3900

agagtgtttc agcacttcat caactccaag gagaagctga atgccctgtt tgcctgtttc     3960

cagtctgagg tggacgaggt gaaggataag gagtacatca tcctgtatct ggaggaggag     4020

atggagaagt ataggcgcgt gcacgagaag tacctgtccg acaagctgtt caacaccaat     4080

gagtataaca tcagcgtgga gaatcagctg tacggcacct ccgattttct gaacggcttc     4140

ccaacaaaga agcccttcct gagccaccag tccgccgtgt ttgacatcgc aggaaggatc     4200

accggagaga tggcaggcaa cctgcacgat tttcaggaga tcatgcggag aaatgtgctg     4260

cctcgcccac tgcccctgtt cgtgtatcgg gaggagctgc agacagagat gctggccgtg     4320

tttagcagat acctggccga cggcaagagg atcggctatc aggagatcat ccgcgagctg     4380

tacaagaacc accaggacga tatcggcgac tactatctgc tgtactatta cggcgatacc     4440

gtgtgcgact ttgatttcgt gtctaggttc cgctacaggc tgcagagcgg cgacaaggag     4500

ggatggatgg tgaaggatca ctttcagatc ggcttcaccg agaagatcag ccacgtgttc     4560

gagctggagg agaaggtgct gcgggagatc tttaacaatt ccctgatcac cagaacaaag     4620

gccggcgaca cacagaggaa gtatttcgat gagctggagc ccaagtactg taagtctgag     4680

aacaattatc tgctggtgct gaagtacaga caggccttct atgactacat ctataagagc     4740

cgcctgcagg cagtgacccg gcctatgttt gatcacatcc tgctgacagg catcctggag     4800

gacatcagac tggatgagct gaagggcaac cagcacaccc agaggtgggg catcctgtcc     4860

aagatgaata tctggttctc tctggccgag cggttcgacc tgcagttcaa gaacaccgat     4920

acaatggcca gcaagctgga ggagcagcgg gtgttcatgg tggccctgtc ccagggagag     4980

gcaatcctgg agaatgacga gcagtacgcc tttgccgccg gccaggtcat ctactacctg     5040

ctgcacaagt ctaagaccgc cgataagagc tataagaggc tggagccctt cctgcagcag     5100

gtgcacgcct ccgagctgaa caaggccatc gcccgcctgt ttgacaccta caagcacgag     5160

aacttttctg gcaatttccg gcacccattt gccagcgtga tggcctatca gacacaggcc     5220

aatatgcgcg actacctgcc catgatgctg gccggcatct tcagcgataa cctgctgttt     5280

tccgtgaata agtctgagga gaccaacgag gagaattga                            5319


<210>  1259
<211>  4341
<212>  DNA
<213>  Bacillus halodurans C-125

<400>  1259
atgggcccca agaagaagag aaaggtaggc agcggcatga ccatcctgga tcacaagatc       60

gacttcgccg tgatcctgtc cgtgacaaag gccaatccta acggcgaccc actgaatggc      120

aacaggcctc gccagaatta cgatggccac ggcgagatct ctgacgtggc catcaagaga      180

aagatcagaa acagactgct ggatatggag gagcccatct ttgtgcagag cgacgatagg      240

aaggccgact ctttcaagag cctgagggat cgcgccgact ccaatcctga gctggccaag      300

atgctgaagg ccaagaacgc ctctgtggat gagtttgcca agatcgcctg ccaggagtgg      360

atggacgtgc gctccttcgg ccaggtgttc gcctttaagg gctccaatct gtctgtgggc      420

gtgcggggac ccgtgagcat ccacaccgcc acaagcatcg atccaatcga catcgtgtct      480

acccagatca caaagagcgt gaactccgtg accggcgata agagaagctc cgacacaatg      540

ggcatgaagc acagggtgga ttttggcgtg tacgtgttca agggctccat caatacccag      600

ctggccgaga agaccggctt tacaaacgag gacgccgaga agatcaagag agccctgatc      660

acactgttcg agaacgattc tagctccgcc aggcctgacg gctccatgga ggtgcacaag      720

gtgtattggt gggagcactc tagcaagctg ggccagtact cctctgccaa ggtgcaccgg      780

agcctgaaga tcgagtccaa gaccgataca ccaaagagct tcgacgatta cgccgtggag      840

ctgtatgagc tggatggcct gggcgtggaa gtgatcgacg gacagggctc cggcgaggga      900

agaggctctc tgctgacctg tggcgacgtg gaggagaacc ctggacctcc aaagaagaaa      960

agaaaagtcg gcagcggcat gcggaacgag gtgcagtttg agctgttcgg cgattacgcc     1020

ctgtttaccg accccctgac aaagatcggc ggcgagaagc tgtcctactc tgtgcctacc     1080

tatcaggccc tgaagggcat cgccgagtcc atctattgga agccaacaat cgtgttcgtg     1140

atcgatgagc tgagagtgat gaagcccatc cagatggagt ctaagggcgt gaggcctatc     1200

gagtatggcg gcggcaacac cctggcccac tacacatatc tgaaggacgt gcactaccag     1260

gtgaaggccc acttcgagtt taatctgcac agacccgatc tggcctttga caggaacgag     1320

ggcaagcact actctatcct gcagcgcagc ctgaaggcag gaggccggag agacatcttc     1380

ctgggagcaa gggagtgcca gggatatgtg gccccttgtg agtttggctc tggcgatggc     1440

ttctacgacg gccagggcaa gtatcacctg ggcaccatgg tgcacggctt caattaccca     1500

gatgagacag gccagcacca gctggacgtg aggctgtggt ccgccgtgat ggagaacggc     1560

tatatccagt ttcctagacc agaggattgc cccatcgtga ggcctgtgaa ggagatggag     1620

ccaaagatct tcaatcccga taacgtgcag agcgccgagc agctgctgca cgacctggga     1680

ggagagggca gcggcgaggg aaggggctcc ctgctgactt gcggcgacgt ggaagaaaac     1740

cctggacctc ccaagaaaaa gaggaaagtg ggcggctccc agctggtgaa gtctgagctg     1800

gaggagaaga agtccgagct gagacacaag ctgaagtacg tgccacacga gtatatcgag     1860

ctgatcgaga tcgccaggaa ccccacccag gatcgcatcc tggagatgaa agtgatggag     1920

ttctttatga aggtgtacgg ctatagggga gagcacctgg gaggctcccg gaagccagac     1980

ggcgccatct acaccgtggg ctctcccatc gattatggcg tgatcgtgga cacaaaggcc     2040

tacagcggcg gctataatct gcccatcggc caggccgacg agatgcagag atatgtggag     2100

gagaatcaga ccaggaacaa gcacatcaat cccaacgagt ggtggaaggt gtaccctagc     2160

tccgtgacag agttcaagtt tctgttcgtg agcggccact ttaagggcaa ttataaggcc     2220

cagctgaccc ggctgaacca catcacaaat tgcaacggag ccgtgctgtc cgtggaggag     2280

ctgctgatcg gcggcgagat gatcaaggcc ggcaccctga cactggagga ggtgaggcgc     2340

aagtttaaca atggcgagat caacttctct gctagcgaga cacctggcac ctccgagtct     2400

gccaccccag agtccggcgg ctctggctct agcggcggct ctggctcctc cggaggaatg     2460

agctggctgc tgcacctgta cgagacatat gaggccaatc tggatcaagt gggcaagacc     2520

gtgaagaagg gcgaggacag agagtacaca ctgctgccaa tctcccacac cacacagaac     2580

gcccacatcg aggtgaccct ggacgaggat ggcgacttcc tgagggccaa ggccctgacc     2640

aaggagtcta cactgatccc atgcacagag gaggcagcct cccgctctgg cagcaaggtg     2700

gcaccatacc ctctgcacga taagctgagc tatgtggccg gcgactttgt gaagtacggc     2760

ggcaagatca agaatcagga cgatgcccca ttcgacacct atatcaagaa tctgggagag     2820

tgggcaaaca gcccatacgc aaccgagaag gtgaagtgta tctacacata tctgaagaag     2880

ggccgcctga tcgaggatct ggtggacgcc ggcgtgctga agctggatga gaaccagcag     2940

ctgatcgaga agtgggagaa gcggtacgag gagctgctgg gcgagaagcc tgccatcttt     3000

agctccggcg caaccgacca ggccagcgcc ttcgtgcggt tcaacgtgtt ccacccagag     3060

tccatcgacg acgtgtggaa ggataaggag atgttcgact cctttatctc tttctataac     3120

gataagctgg gcgaggagga catctgcttc gtgaccggca atcggctgcc cagcacagag     3180

agacacgcca acaagatcag gcacgccgcc gataaggcca agctgatcag cgccaatgac     3240

aactccggct ttaccttccg gggccggttc aagaccagcc gggaggcagt gggaatcagc     3300

tacgaggtgt cccagaaggc ccacaatgcc ctgaagtggc tgatccaccg ccagtccaag     3360

tctatcgacg atcgggtgtt cctggtgtgg tctaatgata acagcctggt gccaaatccc     3420

gatgaggacg ccgtggacat catgaagcac gccaacaggg agctggagcg cgatccagac     3480

accggacaga tcttcgcagg agaggtgaag aaggcaatcg gaggctaccg cagcgatctg     3540

aactatcagc ccgaggtgca catcctggtg ctggactctg ccaccacagg ccgcatggcc     3600

gtgctgtact atcggagcct gaataaggag ctgtacctga accgcctgga ggcctggcac     3660

gattcttgtg cctgggagca ccggtatcgg agagacgaga aggagtttat cagcttctac     3720

ggcgcccccg ccaccaagga tatcgccttt gccgcatatg gacctagggc ctccgagaaa     3780

gtgatcaagg acctgatgga gcggatgctg ccttgcatcg tggatggcag gcgcgtgcca     3840

aaggacatcg tgcggagcgc cttccagaga gcctccaatc ccgtgtctat ggagagatgg     3900

gagtgggaga agaccctgtc catcacatgt gccctgatca ggaagatgca catcgagcag     3960

aaggaggagt ggggcgtgcc tctggataag tctagcaccg accgcagcta cctgtttggc     4020

cggctgctgg ccgtggcaga tgtgctggag aggggcgccc tgggcaagga cgagaccaga     4080

gccacaaacg ccatcaggta catgaatagc tattccaaga accctggccg cacctggaag     4140

acaatccagg agtccctgca gccatatcag gccaagctgg gcaccaaggc cacatacctg     4200

tctaagctgg tggatgagat cggcgaccag tttgagcctg gcgacttcaa caataaccca     4260

ctgaccgagc agtacctgct gggcttctat agccagcgga gagagctgta caagaagaag     4320

gaggaggaga caaaccagtg a                                               4341


<210>  1260
<211>  4290
<212>  DNA
<213>  Desulfovibrio vulgaris

<400>  1260
atgggcccca agaagaagag aaaggtaggc agcggcatga ccgcaatcgc aaaccgctat       60

gagtttgtgc tgctgttcga cgtggagaac ggcaatccaa acggcgaccc cgatgccggc      120

aatatgccta ggatcgaccc agagaccgga cacggactgg tgacagacgt gtgcctgaag      180

agaaagatca ggaaccacgt ggccctgaca aaggagggcg ccgagaggtt caacatctac      240

atccaggaga aggccatcct gaatgagacc cacgagcgcg cctatacagc ctgtgacctg      300

aagccagagc ccaagaagct gccaaagaag gtggaggacg ccaagcgggt gaccgattgg      360

atgtgcacaa acttttacga tatcagaacc ttcggcgccg tgatgaccac agaagtgaat      420

tgtggacagg tgcggggacc agtgcagatg gcctttgcca gatccgtgga gcccgtggtg      480

cctcaggagg tgtctatcac ccggatggcc gtgaccacaa aggccgaggc cgagaagcag      540

cagggcgaca acagaacaat gggcaggaag cacatcgtgc catacggcct gtatgtggca      600

cacggcttca tcagcgcccc cctggccgag aagaccggct tttccgacga ggatctgaca      660

ctgttctggg acgccctggt gaatatgttt gagcacgatc gctccgccgc aaggggactg      720

atgagctccc ggaagctgat cgtgtttaag caccagaata gactgggcaa cgcccctgcc      780

cacaagctgt tcgacctggt gaaggtgtct agggcagagg gctctagcgg ccctgcacgc      840

agcttcgccg attatgcagt gaccgtggga caggccccag agggagtgga ggtgaaggag      900

atgctgggct ccggcgaggg aaggggctct ctgctgacat gcggcgacgt ggaggagaac      960

cctggacctc caaagaagaa aagaaaagtc ggcagcggca tgacccacgg agcagtgaag     1020

acatacggca tcagactgag ggtgtggggc gactatgcct gttttacccg gcctgagatg     1080

aaggtggaga gagtgagcta cgatgtgatg ccaccatccg ccgcaagggg catcctggag     1140

gcaatccact ggaagccagc catcagatgg atcgtggaca gaatccacgt gctgcgcccc     1200

atcgtgttcg ataatgtgcg gagaaacgag gtgtcctcta agatccctaa gccaaaccca     1260

gcaacagcaa tgagggatag gaagcccctg tattttctgg tggacgatgg ctccaacagg     1320

cagcagaggg cagccaccct gctgcggaat gtggactacg tgatcgaggc ccacttcgag     1380

ctgacagaca aggccggcgc cgaggataat gccggcaagc acctggatat cttcaggcgc     1440

cgggcaaggg caggacagag ctttcagcag ccttgcctgg gctgtcgcga gtttccagcc     1500

tccttcgagc tgctggaggg cgacgtgcca ctgtcttgct acgcaggcga gaagcgggat     1560

ctgggctata tgctgctgga catcgatttc gagagagaca tgaccccact gttctttaag     1620

gccgtgatgg aggatggcgt gatcacccct ccatctagga caagccccga ggtgcgcgca     1680

ggcagcggcg agggcagggg ctccctgctg acatgtggcg acgtggaaga aaaccctgga     1740

cctcccaaga aaaagaggaa agtgggcggc tcccagctgg tgaagtctga gctggaggag     1800

aagaagtccg agctgcggca caagctgaag tacgtgcctc acgagtatat cgagctgatc     1860

gagatcgccc ggaatccaac ccaggacaga atcctggaga tgaaagtgat ggagttcttt     1920

atgaaggtgt acggctatag gggagagcac ctgggaggca gccgcaagcc cgatggcgcc     1980

atctacaccg tgggctcccc tatcgactat ggcgtgatcg tggatacaaa ggcctacagc     2040

ggcggctata acctgccaat cggacaggca gacgagatgc agcggtacgt ggaggagaat     2100

cagaccagaa acaagcacat caatcccaac gagtggtgga aggtgtatcc tagctccgtg     2160

acagagttca agtttctgtt cgtgtctggc cactttaagg gcaactacaa ggcccagctg     2220

accagactga atcacatcac aaattgcaac ggagccgtgc tgagcgtgga ggagctgctg     2280

atcggcggcg agatgatcaa ggccggcacc ctgacactgg aggaggtgag aaggaagttt     2340

aacaatggcg agatcaactt ctctgctagc gagacacctg gcacctccga gtctgccacc     2400

ccagagtccg gcggctctgg ctctagcggc ggctctggct cctccggagg aatgatcctg     2460

caggccctgc acggatacta tcagagaatg tccgccgacc ctgatgcagg aatgccaccc     2520

tacggcacca gcatggagaa tatctccttc gccctggtgc tggacgccaa gggcacactg     2580

aggggcatcg aggatctgcg cgagcaggag ggcaagaagc tgagaccaag gaagatgctg     2640

gtgcccatcg ccgagaagaa gggcaatggc atcaagccaa actttctgtg ggagaatacc     2700

agctatatcc tgggcgtgga cgccaagggc aagcaggaga ggaccgataa gtgccacgcc     2760

gccttcatcg cccacatcaa ggcctactgt gacaccgcag accaggatct ggcagccgtg     2820

ctgcagttcc tggagcacgg cgagaaggat ctgtctgcct ttcccgtgag cgaggaagtg     2880

atcggctcca acatcgtgtt cagaatcgag ggcgagcccg gctttgtgca cgagagacct     2940

gcagcaaggc aggcctgggc caattgtctg aacaggaggg agcagggact gtgcggacag     3000

tgtctgatca ccggcgagag gcagaagcct atcgcccagc tgcacccaag catcaaggga     3060

ggaagggacg gcgtgcgggg agcacaggcc gtggccagca tcgtgtcctt taacaatacc     3120

gccttcgagt cttacggcaa ggagcagagc atcaacgcac ccgtgtccca ggaggcagcc     3180

ttttcttacg tgacagccct gaattatctg ctgaatcctt ccaacaggca gaaggtgacc     3240

atcgccgatg ccacagtggt gttctgggca gagcgcagct ccccagcaga ggacatcttt     3300

gccggcatgt tcgatcctcc atctaccaca gccaagcccg agtctagcaa cggaaccccc     3360

cctgaggact ctgaggaggg cagccagcca gatacagcaa gggacgatcc acacgcagca     3420

gcaaggatgc acgacctgct ggtggccatc agatctggca agagggccac cgatatcatg     3480

cccgacatgg atgagagcgt gagatttcac gtgctgggcc tgtctcctaa tgcagcaagg     3540

ctgagcgtgc ggttctggga ggtggacaca gtgggccaca tgctggataa agtgggcaga     3600

cactataggg agctggagat catccctcag tttaacaatg agcaggagtt cccatccctg     3660

tctaccctgc tgagacagac agccgtgctg aataagaccg agaacatctc tccagtgctg     3720

gccggaggac tgttcagggc aatgctgaca ggaggacctt acccacagag cctgctgcca     3780

gccgtgctgg gacgcatccg ggcagagcac gcacggcctg aggacaagtc cagatacagg     3840

ctggaggtgg tgacctacta tagagccgcc ctgatcaagg cctatctgat ccgcaaccgg     3900

aagctggagg tgcccgtgtc cctggaccct gcaaggaccg ataggccata tctgctgggc     3960

cgcctgtttg ccgtgctgga gaaggcacag gaggacgcag tgcctggagc caacgccaca     4020

atcaaggatc ggtacctggc cagcgcctcc gccaatccag gacaggtgtt ccacatgctg     4080

ctgaagaatg cctccaacca caccgccaag ctgcggaagg accctgagag aaagggctct     4140

gccatccact acgagatcat gatgcaggag atcatcgaca atatcagcga tttcccagtg     4200

accatgtcct ctgatgagca gggcctgttt atgatcggct actatcacca gaggaaggcc     4260

ctgttcacaa agaagaataa ggagaactga                                      4290


<210>  1261
<211>  4497
<212>  DNA
<213>  Geobacillus thermocatenulatus strain KCTC 3921

<400>  1261
atgggcccca agaagaagag aaaggtaggc agcggcatga tggagagata tatcgatccc       60

accaagaggc acgagtttgt gctgctgttc gacgtgaagg atggcaaccc taatggcgac      120

ccagatgcag gaaacatgcc ccgggtggac cctgagacaa tgcacggcat cgtgaccgat      180

gtggccatca agagaaagat cagggactat gccgccatgg tgctgggcaa gcctatcttt      240

atccagtctc agacagccct gaacaccatc atcttccagg cctaccagga tgtgggcgtg      300

aagctggcca ccatcgagct gaatgaggag gagaaggaga acggcgagct gatgaattgg      360

ctgagccagc tggaggagca gggactggtg ctggaggaca atagagtgat ctacacaggc      420

gaggatatca aggagaagga catcagggag aagctgaccg agggcctgga ggaggcaggc      480

ctgaagaagc agctggagaa gagcctgcgc aacatggcaa agcggctggc ccaggccgcc      540

aacaatatga agatcgatga gcagacccgc cagaatgccc agaaggccct gtgccagaag      600

tactatgacg tgcggatgtt cggcgccgtg atgtccacag gcctgaacgc aggacaggtg      660

aggggaccaa tgcagctgac cttttcccgc tctatcgatc ccgtgttccc atgggacctg      720

accatcacaa gaagcgccat cacaaaggag tccgatcgga gaaggaagca gaccgagatg      780

ggccgcaagc ccctgatccc ttacggcctg tatcggctgc acggctttta caatcccttc      840

ctgggcgaga agacaggagt gaccgcagag gacctggcag atttttggga cgccctggtg      900

cacctgttcg cctttgacca cagcgccgca aggggagaga tgaacgtgcg ggccctgtat      960

atcttttccc acgagaatgc caagggctct gcccctgccc acaagctgtt cgatctggtg     1020

aagatcgagc gccggcagca ggaggcacca agatccttcc acgactacgt gctgctggga     1080

ccagcagatg agggacagaa ggacgtgttt ctggagggct tctctggcgt gaccgtgaca     1140

cggctggtgg gctctggcga gggaagaggc agcctgctga cctgcggcga cgtggaggag     1200

aaccctggac ctccaaagaa gaaaagaaaa gtcggctccg gcatgcagag aagggccaag     1260

gtgcaggtga aagtgtgggg cgagtacgcc tgttttacac gcccagagtt caaggtggag     1320

cggatcagct atccagtgat gaccccatcc gccgcaaggg gcgtgctgga ggccatcttt     1380

tggaagcccg agttcagata cgaggtgagg cagatcggca tcctgagcct gggaggacag     1440

caggcaatcc tgcggaacga gctgacatcc aagcagaaca agaatcctat cgtgatcgag     1500

tctgccaggg cacagcggac cagcctgatc ctgaagaacg tggcctactg gatcgtggcc     1560

gatatcatcc tgacaaatag ggcagtggac cccgcagcca agtatagaga ccagttcaat     1620

cgccgggtgg agaggggaca gtgccaccac acaccttacc tgggcacccg cgagtttgcc     1680

gcctatttca gctccatcga cgaggacgat gtggtgaagc cagtggacat ggatatcggc     1740

accatgctgc tggatttcgc ctttatcgag gacggcagca gaaaggagat ggagtttctg     1800

agatacgagg agaccggaac acgcaccgca gtgggattcg caaagccact gttctttgag     1860

gccaaggtgg agaacggctg gctgcacgtg cccaaggaga cctaccagca gctgtatgcc     1920

ctggagggcc agaatgccct gagggtggat ggctccggcg agggaagggg ctctctgctg     1980

acatgtggcg acgtggaaga aaaccctgga cctcccaaga aaaagaggaa agtgggcggc     2040

tcccagctgg tgaagtctga gctggaggag aagaagagcg agctgaggca caagctgaag     2100

tacgtgcctc acgagtatat cgagctgatc gagatcgcca gaaatccaac ccaggataga     2160

atcctggaga tgaaagtgat ggagttcttt atgaaggtgt acggatatag gggagagcac     2220

ctgggaggct ccagaaagcc agacggagcc atctacacag tgggctctcc tatcgattat     2280

ggcgtgatcg tggacaccaa ggcctactcc ggcggctata acctgcccat cggccaggcc     2340

gacgagatgc agaggtacgt ggaggagaac cagacccgca ataagcacat caaccccaat     2400

gagtggtgga aggtgtatcc ttctagcgtg acagagttca agtttctgtt cgtgagcggc     2460

cacttcaagg gcaactacaa ggcccagctg acacggctga atcacatcac caactgtaat     2520

ggagccgtgc tgtccgtgga ggagctgctg atcggcggcg agatgatcaa ggccggcaca     2580

ctgaccctgg aggaggtgag aaggaagttt aacaatggcg agatcaactt ctctgctagc     2640

gagacacctg gcacctccga gtctgccacc ccagagtccg gcggctctgg ctctagcggc     2700

ggctctggct cctccggagg aatgcactgg agagataaga tgctgtatga gctgatcgag     2760

ctggccgcca agctgcagag ggagaagaag ctgcctccaa tcagctacaa gcccaagtcc     2820

atcaactgga tcatcgatct gggaggcgac cagccttacc tgaagggacc atttcgccgg     2880

ggagagtata ggctggtgga ggcacctttc cgcctgaggc agggcaaggt gaccgaggag     2940

aatgtgaagc catacctgct ggccgacgat ggcagatatg tgctgggcat cccagagtcc     3000

cccgagaagg cagacgaggc agagctgatg cacaagggct acgtgaggct gatcgaggag     3060

gcctatgaga agacaaagct gaaggagctg aagaaggtgc tggattttct gtattctcct     3120

atgaagaacg ccttccggga gcagatcggc gccaaggaca tcgtgacatt ccaggacgat     3180

gaggagagcc tgatctttga gaagtccgag atccagacct tctgggccga gtacctggcc     3240

tccgatctgc tgtctgacga tgagtgcgac tgtagcgtgt gcggcaagag aagcgcctac     3300

gtgaggtatc tgccaaatcc cgtgcagctg tttggccagt cttgtcagct gaccagcttt     3360

aacaatccct ctttcgagag catgggcaag acacagacca acaatgtgcc cgtgtgcttc     3420

ggctgtgcca cactggtggt ggataccctg aactacctga tcagagagga ccagcaccac     3480

acacctctgt atatctccga taggaatatc ctgcagtctc agatggccat ctactgggtg     3540

gacgatcaga tcgagggcag aggctgcatc cagctggacg agaagctgtt tgcctctcct     3600

atcgagcagt ggctgttcga cgaggataca aaccagcgca ccccccctcc agagctgaag     3660

cagctggagg agctgctggc cctgccaaag acaggaaggg agcaggccct gcacctggac     3720

aagaccttct ttcacatggc cgtgctgtcc gccaataagg caaggctggt ggtgcgggag     3780

tggattcaca cctccatctc tcagctgctg atgcacctgg agcggtacgc agcagccgtg     3840

cggatcgtgc agcctacagg cgagaagggc tatctgctgc cactggccgc cctgatcagg     3900

gcagtggata tgagcccagg cctggtgaga cagtgtctga ggacaatcta tcagggcgcc     3960

ctgccaccta ccgagctgct gcccctggcc ctgcagcggt tcagaagcct gaaggtgctg     4020

tctgacccta aggagacctg gagataccac tctagcgcct ctctgctgaa gctggtgctg     4080

acatatggca aggaggaggc caacaccatg cagagcctga acaatcactg cctgcagccc     4140

gcctacatct gtggcaggct gctggccgtg ctggaggaga tccagagaag ggccctgggc     4200

taccggatcg gctctaccat cgtggatcgg ttctacggag cagccagcac agcacctgcc     4260

agcaccttcg gctccctgct gaggctgagc accacagcac acctgccaaa ggtgtccggc     4320

gagctgggcc ggctgctgga ggaagtgatg aagcagctgg acgaggcagg aggatttcca     4380

acaatcttca atctgaggga gcaggcagag tttgcactgg gcttctacca ccagagggca     4440

gagttccgct ctcggcacca gagcaaccag acaaatggca ccggcgagtc ccagtga        4497


<210>  1262
<211>  4806
<212>  DNA
<213>  Vibrio cholerae strain L15 L15_contig8

<400>  1262
atgggcccca agaagaagag aaaggtaggc tccggcatgg ccaagaacaa tgacatcgcc       60

tctgtgctgg ccttcgagaa gaagctggtg cctagcgatg gctacctgtt tggctgccag      120

tgggagacca aggagcaggc caccccactg acactgcagg agaagagcgt gagaggcaca      180

atctccaaca ggctgaaggc cgccgtgcag aacgaccctg ccaagctgaa tgccgaggtg      240

gagaaggcca atctgcagcg ggtggatgcc tgtgcactgg gacaggacca cgataccctg      300

aagctgcact tcacactgaa ggtgctggga ggcctggccc agccatctgc ctgcaacaat      360

gccctgttta agcagtctta cagcaccgcc gtgagccagt acatcacaaa gtatggctgt      420

ttcgagctgg ccaagagata tgccaccaac ctggccaatg ccaggtttct gtggcggaac      480

agagtgggcg ccgaggagat cgaggtgcag gtgaaggccc tgaacaaggg cgccgagcag      540

acctggacct tcaacgccaa gcagttctct accaggcact ttgaccacaa cgatagccag      600

ctgaattccc tggccgacag gatcgcacag gccctggcca gcgagacaga ccacctgatg      660

ctgcagatcg attgctacgc caaagtgggc aaggcccagg aggtgtatcc ctccgaggag      720

ctggtgctgg ataagggcaa cagcaagacc aagaagtcca agatcctgta cgccgtgaac      780

gagcacgccg ccatgcactc tcagaagatc ggcaatgccc tgcgcagcat cgacacatgg      840

taccctgatt atgcctctga ggagcagagc gccggagcaa tcgcaatcga gccctacggc      900

gccgtgacca atctgggcaa ggccttcaga acccctaagg acaagcagga cttctacacc      960

ttctttgaca agtgggcaag gggagagagc ctgcctaggg aggaggatga gcactacgtg     1020

atggccgtgc tggtgcgggg aggcgtgttc ggagagtccg acaagggctc tggcgaggga     1080

agaggcagcc tgctgacctg tggcgatgtg gaggagaacc ctggacctcc taaaaagaaa     1140

cgaaaggtag gctccggcat gaattactat caggagatca cactgctgcc cgacgcagat     1200

atcgccctgg gcttcctgtg gcagaacgtg tttcagcagg tgcacatcgc cctggtggag     1260

cacaaggtgg cctctaatca gagcctggtg gccgtgggct tccctgacta cagacaggcc     1320

aagtttccac tgggcgccaa gctgaggctg ttcgccaagg agcaggtgac cctggagaag     1380

ctggacatcc acagatggct gacaaggctg gaggattacg tgcacatcaa gggcgtgaag     1440

ccagtgccct ctgacgtgac ctatgtgagc tttgtgagaa agcaggtgaa gtcccccgag     1500

cggatcgaga gagatatgca gcagaaggcc gagctgtggg ccgccaagtc tggcaagcct     1560

ctggtggagt gcctggtgga cctgcagcag tccaagccca ccgccctgtg ctctctgcct     1620

ttcatctacc tgcacagcca gcagacaaag cagaggtctc cagagaagaa cagcaagttt     1680

cccctgttca tcgagatgca gcagcagtcc acatctcagg acggcggctt cgattgctat     1740

ggcctgagct ccaaggccaa tggccagagc atgctggcca ccgtgccaca ctttggctcc     1800

ggcgagggaa ggggctctct gctgacatgt ggcgacgtgg aagaaaaccc tggacctcca     1860

aagaagaaaa gaaaagtcgg ctccggcatg aatgtgctga tcctgcctca cctgaagatc     1920

cacaacgcca atgccctgtc tagccccttt accgtgggct tccctgccat gacagcatgg     1980

ctgggattcg tgcacgccct ggagagaaag ctgtcccagg ccggcctgtc tgatctgatg     2040

ctgcacagca ccgcagtggt gtcccacagg tgcgacgtgc agacacacaa gggcgagggc     2100

gatttcgtgc acagcatcat cggcaccgcc aaccccctgg acaaggatgg cagccgctcc     2160

gcctttatcg aggaggcccg gtgtcacctg gacgtgagcc tggtcatcga gtggtccggc     2220

aatgaggagc aggtgcagca gcctgagttt accgagcagc tgcaggccgt gatcgccaca     2280

atgaaggtgg caggaggcga tgtgctggcc gtgggcaagc cttccgtgaa gtctgtgatc     2340

accgaggacg atacaggcag ggtgctgagg cagctgatgc caggatacgt gctgatcgag     2400

cggagagacc tgatgatcga tgccatgcag cagggcgacg atgcaatcga cgccctgctg     2460

ggctatctga ccgtgcacca ccactgcgag cagctggagg atcagtctgt ggtgtggcac     2520

agccagcgga agacctccgg ctggatcgtg cccatcgcca caggcttcca gggcatctcc     2580

cctctgggcg aggccaagaa ccagagagac cctagcgtgc cacacaggtt cgcagagtcc     2640

gtggtgaccc tgggagagtt tgtgatggtg cacaagatca agcacctgga cgatatcctg     2700

tggcagtacc acccagacct ggagaacgat ctgtatctgt gccagaaggt gaacgccatc     2760

aatgagcacc agggctctgg cgaaggcagg ggcagcctgc tgacatgcgg cgatgtggaa     2820

gagaaccctg gacctcccaa gaaaaagagg aaagtgggcg gctctcagct ggtgaagagc     2880

gagctggagg agaagaagag cgagctgcgg cacaagctga agtacgtgcc tcacgagtat     2940

atcgagctga tcgagatcgc cagaaaccca acccaggaca gaatcctgga gatgaaagtg     3000

atggagttct ttatgaaggt gtacggctat agaggcgagc acctgggcgg ctctaggaag     3060

ccagatggcg ccatctacac cgtgggcagc cccatcgact atggcgtgat cgtggataca     3120

aaggcctact ccggcggcta taatctgcca atcggacagg cagacgagat gcagcggtac     3180

gtggaggaga accagacccg gaataagcac atcaacccca atgagtggtg gaaggtgtac     3240

ccttcctctg tgacagagtt caagtttctg ttcgtgagcg gccacttcaa gggcaactat     3300

aaggcccagc tgaccagact gaatcacatc acaaactgta atggagccgt gctgtccgtg     3360

gaggagctgc tgatcggcgg cgagatgatc aaggccggca ccctgacact ggaggaggtg     3420

aggcgcaagt tcaacaatgg cgagatcaac ttttctgcta gcgagacacc tggcacctcc     3480

gagtctgcca ccccagagtc cggcggctct ggctctagcg gcggctctgg ctcctccgga     3540

ggaatgatcg acccagtgat cgccgccttc tttgccgaga ggaaggaggc ctggctgaag     3600

aagaatatca gcgccgcaat gtccgatgca gaggtgctgg agaagcagca ggagtgcgag     3660

cagaacttcc tgctggacaa ttggctgccc gatgcagcaa agagggcagg acagatctct     3720

gtggccagcc acccatgtac attttcccac ccctctgccc gcaagaacaa gaatggctac     3780

gtgtcctcta tcatcgccaa gaacaagcca cgcatcgacg gcttcctgcg gtctggcaac     3840

gtgagcgtgg agccagacgc cctgggaaat gcagccgccc tggacgtgta caagtttctg     3900

tccctggaga tgtctgatca gcgcagcctg ctggtgcaca tcgagcagga gagcgagctg     3960

gccaggcagc tgctggacat cccttcctgc gagtatcagg ccctgagaga tggcttcctg     4020

aagatggtgg actccgatca ggcctctgtg agctcctcta agatcaagca ggtgtacttt     4080

ccaatcgccg acggcgagta tcacctgctg tccctgctga cccactctgg ccacctgttc     4140

gagctgagga agcgcctgga cgccctgagg tttggcgatg ccgtgaagga ggcccgggag     4200

tgtaagaaga ccaaccactt ccacccagcc ggctaccagg agatcttcgg cctgaccaca     4260

atcggctttg gcggcacaaa gccccagaac atcagcgtgc tgaacaatca gaatgcaggc     4320

aaggcacacc tgctggcctc catcccccct gagctgaccc ctcgggacat cagactgcca     4380

aagacagatt tctttaagga gtccttcaac gcctggcagg ccaaggaggt gctggagtct     4440

ctgcacagac tgtttcagac cgactgcaac aatatcaatc tgagggacgg ccgcgattac     4500

agaatccagc agtatgtgga cctggtcatc gagaagatgt ggcaggtgag gctgttcctg     4560

gaggcctaca gcggcgagct gagctccgcc ctgcctctgg agcagaagat ctggctgtat     4620

ccagagtttg cagagcagag gcagcaggag gacgagtggc tggataagat catccgccac     4680

atcgcccggg gcctgatcaa ccactacagc cggtccaaag tgatcaccaa tcctgtgaca     4740

ctggccgacc aggagctgct ggccatcgag gaggtggtgg cctccaacaa ggagaatctg     4800

agatga                                                                4806


<210>  1263
<211>  4866
<212>  DNA
<213>  Pseudomonas aeruginosa UCBPP-PA14

<400>  1263
atgggcccca agaagaagag aaaggtaggc tctggcatga gcaagcccat cctgtccacc       60

gcctctgtgc tggcctttga gcggaagctg gacccttctg atgccctgat gagcgccgga      120

gcatgggcac agagagatgc cagccaggag tggccagccg tgacagtgag agagaagtcc      180

gtgaggggca ccatctctaa ccgcctgaag acaaaggacc gggaccccgc aaagctggat      240

gccagcatcc agtcccctaa cctgcagacc gtggacgtgg ccaatctgcc aagcgacgcc      300

gataccctga aggtgcgctt cacactgcgg gtgctgggag gagcaggaac accatccgcc      360

tgcaatgatg ccgcctatag agacaagctg ctgcagaccg tggccacata cgtgaacgac      420

cagggatttg cagagctggc ccggagatac gcccacaacc tggccaatgc caggttcctg      480

tggaggaaca gggtgggagc agaggcagtg gaggtgcgca tcaatcacat caggcaggga      540

gaggtggcaa gggcatggcg gtttgatgcc ctggccatcg gcctgagaga cttcaaggca      600

gatgcagagc tggacgccct ggccgagctg atcgccagcg gcctgtctgg cagcggccac      660

gtgctgctgg aggtggtggc ctttgccagg atcggcgacg gccaggaggt gttcccttcc      720

caggagctga tcctggacaa gggcgataag aagggccaga agtccaagac cctgtactct      780

gtgcgggatg cagcagcaat ccacagccag aagatcggca atgccctgag aaccatcgac      840

acatggtatc cagacgagga tggactggga ccaatcgcag tggagcctta cggctctgtg      900

accagccagg gcaaggccta taggcagccc aagcagaagc tggacttcta cacactgctg      960

gacaattggg tgctgaggga tgaggcacct gcagtggagc agcagcacta cgtgatcgcc     1020

aacctgatca ggggaggcgt gttcggagag gcagaggaga agggcagcgg cgagggaagg     1080

ggctccctgc tgacctgtgg cgacgtggag gagaaccctg gacctcctaa aaagaaacga     1140

aaggtaggct ccggcatgga tcactatctg gacatcagac tgaggccaga tcccgagttt     1200

ccacccgccc agctgatgtc tgtgctgttc ggcaagctgc accaggccct ggtggcacag     1260

ggaggcgacc ggatcggcgt gtcttttcca gacctggatg agtcccgctc tcggctggga     1320

gagcggctga gaatccacgc cagcgccgac gatctgagag ccctgctggc caggccatgg     1380

ctggagggac tgcgcgatca cctgcagttc ggagagcctg cagtggtgcc tcacccaacc     1440

ccctacagac aggtgtctag ggtgcaggcc aagagcaacc cagagcggct gaggcgccgg     1500

ctgatgagaa ggcacgacct gagcgaggag gaggcaagga agagaatccc cgacacagtg     1560

gcacgcgccc tggatctgcc ctttgtgacc ctgcggagcc agtccacagg ccagcacttt     1620

cgcctgttca tcaggcacgg accactgcag gtgaccgcag aggagggagg cttcacatgc     1680

tatggcctgt ccaagggcgg ctttgtgcct tggttcggct ccggcgaagg caggggctct     1740

ctgctgacct gtggcgatgt ggaggagaac cctggacctc caaagaagaa aagaaaagtc     1800

ggctccggca tgtctgtgac agaccctgag gccctgctgc tgctgccaag actgagcatc     1860

cagaacgcca atgccatcag ctccccactg acctggggat tcccttcccc aggcgccttt     1920

acaggattcg tgcacgccct gcagcgccgg gtgggcatct ccctggatat cgagctggac     1980

ggagtgggaa tcgtgtgcca ccgctttgag gcccagatct ctcagccagc cggcaagcgg     2040

accaaggtgt tcaacctgac acgcaacccc ctgaatcggg atggctctac cgcagcaatc     2100

gtggaggagg gaagagcaca cctggaggtg agcctgctgc tgggagtgca cggcgacggc     2160

ctggacgatc acccagccca ggagatcgca agacaggtgc aggagcaggc aggagcaatg     2220

aggctggccg gaggctctat cctgccatgg tgcaacgaga ggtttcccgc ccctaatgca     2280

gagctgctga tgctgggagg cagcgacgag cagagaagga agaatcagcg ccggctgacc     2340

agaaggctgc tgccaggatt cgcactggtg agcagagagg ccctgctgca gcagcacctg     2400

gagacactga ggaccacact gcctgaggca accaccctgg acgccctgct ggacctgtgc     2460

agaatcaact ttgagccacc tgccacctct agcgaggagg aggccagccc acccgacgca     2520

gcctggcagg tgagggataa gcctggatgg ctggtgccaa tcccagcagg atacaacgcc     2580

ctgtcccctc tgtatctgcc aggcgaggtg cgcaatgcca gagataggga gacacccctg     2640

cggtttgtgg agaacctgtt cggcctgggc gagtggctgt ctcctcacag ggtggccgcc     2700

ctgagcgatc tgctgtggta tcaccacgcc gagcctgaca agggcctgta cagatggagc     2760

accccaaggt tcgtggagca cgcaatcgca ggcagcggcg aaggcagagg ctccctgctg     2820

acatgcggcg acgtggagga gaaccctgga cctcccaaga aaaagaggaa agtgggcggc     2880

agccagctgg tgaagtccga gctggaggag aagaagtccg agctgcggca caagctgaag     2940

tacgtgcctc acgagtatat cgagctgatc gagatcgcca gaaacccaac ccaggataga     3000

atcctggaga tgaaagtgat ggagttcttt atgaaggtgt acggctatag aggcgagcac     3060

ctgggaggct ccaggaagcc agacggagca atctacaccg tgggctctcc tatcgactat     3120

ggcgtgatcg tggatacaaa ggcctacagc ggcggctata atctgccaat cggacaggca     3180

gacgagatgc agcggtacgt ggaggagaac cagacccgga ataagcacat caacccaaat     3240

gagtggtgga aggtgtaccc ctcctctgtg acagagttca agtttctgtt cgtgtctggc     3300

cacttcaagg gcaactataa ggcccagctg acccgcctga atcacatcac aaactgtaat     3360

ggagccgtgc tgtccgtgga ggagctgctg atcggcggcg agatgatcaa ggcaggcacc     3420

ctgacactgg aggaggtgcg ccggaagttt aacaatggcg agatcaactt ctctgctagc     3480

gagacacctg gcacctccga gtctgccacc ccagagtccg gcggctctgg ctctagcggc     3540

ggctctggct cctccggagg aatgacatct cctctgccaa cccccacatg gcaggagctg     3600

agacagttta tcgagagctt catccaggag aggctgcagg gcaagctgga taagctgcag     3660

cctgacgagg acgataagcg gcagaccctg ctggccacac acagaaggga ggcctggctg     3720

gccgatgcag cacgccgggt gggacagctg cagctggtga cccacacact gaagccaatc     3780

caccctgacg caaggggctc taatctgcac agcctgccac aggcaccagg acagcctggc     3840

ctggccggct ctcacgagct gggcgatagg ctggtgagcg acgtggtggg aaacgcagcc     3900

gccctggacg tgtttaagtt cctgtccctg cagtaccagg gcaagaacct gctgaattgg     3960

ctgaccgagg atagcgccga ggccctgcag gccctgtccg acaatgcaga gcaggcaaga     4020

gagtggaggc aggcctttat cggaatcacc acagtgaagg gagcaccagc cagccactcc     4080

ctggccaagc agctgtactt tcctctgcca ggcagcggct atcacctgct ggccccactg     4140

ttccccacct ccctggtgca ccacgtgcac gccctgctga gggaggcaag gttcggcgac     4200

gcagccaagg ccgccagaga ggcacgctcc cggcaggagt cttggccaca cggctttagc     4260

gagtacccta atctggccat ccagaagttc ggcggcacca agccccagaa catctcccag     4320

ctgaacaatg agagaagggg cgagaactgg ctgctgcctt ctctgccccc taattggcag     4380

agacagaacg tgaatgcccc aatgaggcac tccagcgtgt tcgagcacga tttcggccgc     4440

acccctgagg tgagcagact gaccaggaca ctgcagcggt tcctggccaa gacagtgcac     4500

aacaatctgg ccatcagaca gaggagggca cagctggtgg cacagatctg cgacgaggcc     4560

ctgcagtacg cagcaagact gagggagctg gagccaggat ggtccgccac cccaggctgt     4620

cagctgcacg acgcagagca gctgtggctg gaccccctga gggcacagac cgacgagaca     4680

tttctgcaga gaaggctgag gggcgattgg ccagcagaag tgggaaacag gttcgcaaac     4740

tggctgaatc gggccgtgag ctccgactct cagatcctgg gcagccccga ggcagcacag     4800

tggagccagg agctgtccaa ggagctgacc atgttcaagg agatcctgga ggacgagagg     4860

gattga                                                                4866


<210>  1264
<211>  3405
<212>  DNA
<213>  Shewanella putrefaciens CN-32

<400>  1264
atgggcccca agaagaagag aaaggtaggc agcggcatgc agaaggtgac cggcatcaag       60

tccgtggact tcaagatcaa ggccctgggc cacggcgtgg tgaactggaa tggccccacc      120

acactgacag gcgacgatgg caagaccgtg gacaatcaca cactgcctaa gctgagaggc      180

tacaccaacc tgacaggcaa ggtgaaggat gagaccggct acaagtataa gaagcaggcc      240

accgacatca atttcaagga gacacctctg tacatcagcc agaactgcat ccggcaccac      300

ctgtttagag agcaggcctt cgatctgcac tatgcctctg acaagaacct gaagaatgtg      360

ctggccagca tcaccggact gatcagggga tacgtggtgc caagctccca gtgtaagcgg      420

acatcccccc tgctgctgga ggattttgtg gaccagctgg gcaacggcaa tttcgagcag      480

tacggacagg caggagcaag ggatagcacc tccttcttta gcaagaccac attcggcgac      540

acagagtaca tctcctatgg ctctatcagc atcgagcagc tgcagtttat cagcctggat      600

aagaagttcg accgcgccgc catggtcatc aaggagggag agggagaagt gatcgcagca      660

gagctgcaga attacatcca gagcctgaac ccctccctga atcctcaggc catctttcac      720

tctaactatg tgcggagagg caccatcttc gaggagggcg agtgcggcat cctgctgaat      780

gacgatgcag tgaaggccct ggtggcagag accctggaga gactggccaa cctgtccatc      840

aggcaggcca agggctacat gtatgtggac gatatcacag tggattacaa tgactctcac      900

aagatgatgc ggatcaagag agatgagagc gagatcatca acgagcagca cgcccctttt      960

gcccagtact tctatgcaaa gggctctggc gagggaaggg gcagcctgct gacctgtggc     1020

gacgtggagg agaaccctgg acctcctaaa aagaaacgaa aggtaggctc tggcatgaac     1080

agctatatcg atatccgcct gaagccagac gcagagatga gggaggcaga gctgtctagc     1140

aaggtgttta ccaagttcca caaggccctg gtgacactga actcccacaa gatcggcatc     1200

tcttttccac agatgaagct gtccctgggc cagctgttca gaatccacgg cgatgcctct     1260

ctgctgcacg atctgcaggg cctggactgg ctgggacctc tggccggata ctgccaggtg     1320

accgccgtga gcgccgtgcc agaccacgtg cagtatagga tcgtgtccgt gaagcggagc     1380

aatctgagca aggccaagct gaagaggctg atcgcccgcg gcagcatcga caaggatggc     1440

gagaagcggt acaaggtgaa gatgctgggc cagggctttg ataacccata cctggacctg     1500

ttctcctcta gcaccggcca ggtgtataga aagttctttg agttttccga tatccaggcc     1560

cacccactgg atggcgagtt cgactcctat ggcctgtcta agaccgcaac agtgccatgg     1620

ttcggcagcg gcgagggcag aggctccctg ctgacatgcg gcgacgtgga agagaaccct     1680

ggacctccaa agaagaaaag aaaagtcggc ggctctcagc tggtgaagag cgagctggag     1740

gagaagaaga gcgagctgcg ccacaagctg aagtacgtgc cccacgagta tatcgagctg     1800

atcgagatcg cccggaaccc tacccaggat agaatcctgg agatgaaagt gatggagttc     1860

tttatgaagg tgtacggcta tagaggcgag cacctgggag gctctaggaa gcctgacgga     1920

gccatctaca ccgtgggcag cccaatcgat tatggcgtga tcgtggacac aaaggcctac     1980

tccggcggct ataacctgcc aatcggacag gcagacgaga tgcagcggta cgtggaggag     2040

aaccagaccc ggaataagca catcaaccca aatgagtggt ggaaggtgta cccctcctct     2100

gtgacagagt tcaagtttct gttcgtgtcc ggccacttta agggcaatta taaggcccag     2160

ctgacccggc tgaaccacat cacaaactgc aatggcgccg tgctgtctgt ggaggagctg     2220

ctgatcggcg gcgagatgat caaggccggc accctgacac tggaggaggt gaggcgcaag     2280

tttaacaatg gcgagatcaa tttctctgct agcgagacac ctggcacctc cgagtctgcc     2340

accccagagt ccggcggctc tggctctagc ggcggctctg gctcctccgg aggaatgaag     2400

atcatcatcg agtacgactc ctgctggaga aacgccttcc tgggcggctc taacaatgag     2460

cctgtgccaa agaagggcag ggagtttctg ggcagcatga catccctgaa gaaggagggc     2520

aacttcaagg tgtgcgagaa taccctggat acagtgatgg gcgtgctgaa caggctgatc     2580

ggcgaccaga ggaagctgta ccaggcacgg tccaagatgt atgagtctgc ctactatttt     2640

gaggccctgg aggataaggt gagcttcatc gacaagcccc agctgaccaa tgagatctcc     2700

tttatcagaa acatgaatgg ctctaccgat cagaacgcct tcacaggcat gatcaaggtg     2760

agcgaccccg tgttcacctc tgagtacagc cagcagttct ggggcgtgct ggccctggac     2820

ttcacccagc tgtgcgactt catcatcaag cagagccagg tggtgggctc catcgagctg     2880

aaccccctgt ctatcatcaa taggctggag agcctgaacc aggagaaggc cctggagaat     2940

agcgacgatc tggcccaggt gctgaaggtg ctgaacgagt actttccaga catcgagtat     3000

ctgaacaata agggcctgat cacccccatc agcatctact gttccgccct gtatctgcag     3060

ctggcccgcc tggagacctc cttcaatatg accacagcca agacaaaggc cggcggcatc     3120

tccggcatct ctaagagagg ctttaccaag aaggatttca tggacaggta caccacaggc     3180

cccaagaaga caatctgggg caaccctttt atcaagaagg agaagatcaa gggccagggc     3240

gaggtgacct ctatgatgac aaaggccagc ggccagctgg agatctccat cgacgtggat     3300

cgggacaagg cccaggagat caagatcctg atcgagaatg ccggcgtgtc ctctttctac     3360

ctgggcaaga agggcctggc ctatgtgagc aacatcaagc tgtga                     3405


<210>  1265
<211>  3501
<212>  DNA
<213>  Acinetobacter sp. 869535

<400>  1265
atgggcccca agaagaagag aaaggtaggc agcggcatgg ccaaggtgac aggcgtgaag       60

tccgtggact tcaagatcac cgcctacggc tatggcgtgg tgaactggaa tggcccaaca      120

agcctgaccg gcaatgacgg caagacagtg gataaccaca ccctgcccaa gctgagaggc      180

ttctccaatc tgtctggcag ggtgaaggag gagacaggct acaagtatag gaaggaggcc      240

tctgacatcg acttcaacga gacccctctg tacatcagcc agaactgcat caggcaccac      300

ctgtttcgcg accagtcctt cgatctgcac tatgccaagg acaagaacct gatcgatgtg      360

ctggcctcta tcaccggact gatcagggga tacgtggtgc caagctccca gtgtaagcgg      420

acaagccccc tgctgatcac cgacttcatc gatcagctgg gcaacggcaa ttttgagcag      480

ctgagcaatg cctctagctc cgaggagatc acacaggacg atggctccaa gacctacaag      540

cgcggcgaga acagcatctt ttccaagacc acattcggcg acaccgagta catcgcctat      600

ggctccatct ctatcgagca gctgcagttt atctccctgg acaagaagtt cgatagagcc      660

tctatgatca tcaaggaggg cgagggcgag aagatcgccg agagggtgca ggagttcatc      720

aagagcctgg accccagcaa ggagcctaag gccatcttcc acaagaatta cgtgcggaag      780

ggcacaatct ttaacgaggg cgaagtgggc atcctgctgg acaatacagc catcgatatc      840

ctggtgaagg agaccctgag catgctggag gagctggtca tcaagcaggc caagggctac      900

atgtgcgccg acaccgtgga ggtggactat aacgattccc acaagatgat gaggatcaag      960

cgcaatccag accaggccaa ccccgagctg cagcaggatt acgccgtgta tttcgaggca     1020

cagggcagcg gcgagggaag aggctccctg ctgacatgtg gcgacgtgga ggagaaccct     1080

ggacctccta aaaagaaacg aaaggtaggc agcggcatga attactatat cgaggtgacc     1140

ctgatggaga acgatcagtt ttctccttac gagctgtgga gccagctgta tccacagctg     1200

cacctggccc tggtggaggc aaagaacgcc gacaataagg tgaacatcgg cttctccttt     1260

ccccagtacc gctttcacca ggataagggc gtgggcttca tcggcaccaa gctgcggctg     1320

tttgccgagt ccgaggccga cctgaagaag ctggatatcc ggcggtggct ggagagactg     1380

gaggactatg tgcacgtgac atctatcagg gaggtgccca atgatatcaa gaactacgcc     1440

atctataaga ggaagcaggt gaagaccaac gcacagcgcc tggccaggca cagagtgaag     1500

cggggcgaca tcggcttcga tgaggccctg gcccgctaca gcaatgtggt gaccacaacc     1560

aacatgcctt atatcgagat gaagagcctg tccacatctg accagcagtc tgagaagcgg     1620

tttaagctgt tcatcgagaa gcagtccgcc gagaagtctg agacacaggt gttcagcacc     1680

tacggcctgt ctagcgtgtc ctctgtgcct gagtttggct ccggcgaggg aaggggctct     1740

ctgctgacct gcggcgatgt ggaggagaac cctggacctc caaagaagaa aagaaaagtc     1800

ggcggctctc agctggtgaa gagcgagctg gaggagaaga agagcgagct gagacacaag     1860

ctgaagtacg tgcctcacga gtatatcgag ctgatcgaga tcgcccggaa cccaacccag     1920

gacagaatcc tggagatgaa agtgatggag ttctttatga aggtgtacgg ctatagagga     1980

gagcacctgg gaggctccag gaagccagat ggagccatct acacagtggg ctctcctatc     2040

gactatggcg tgatcgtgga taccaaggcc tactccggcg gctataacct gccaatcgga     2100

caggcagacg agatgcagcg gtacgtggag gagaatcaga cacggaacaa gcacatcaac     2160

cctaatgagt ggtggaaggt gtacccaagc tccgtgaccg agttcaagtt tctgttcgtg     2220

agcggccact tcaagggcaa ttataaggcc cagctgacaa gactgaacca catcaccaac     2280

tgtaatggag ccgtgctgtc cgtggaggag ctgctgatcg gcggcgagat gatcaaggcc     2340

ggcacactga ccctggagga ggtgaggcgc aagtttaaca atggcgagat caatttctct     2400

gctagcgaga cacctggcac ctccgagtct gccaccccag agtccggcgg ctctggctct     2460

agcggcggct ctggctcctc cggaggaatg cagatcatca tcgagtacga gagctcctgg     2520

cgcaactcct tcctggacgg ctctaacaat gagcctctgc caaagggcgg ccggaacttc     2580

atcgcctcca tgacaaccct gaagcaggag ggcaactaca agaagcggag catctctaag     2640

gatacagtga tgggcatcct gaacaggctg atcggcgacc agcgcaagct gtatcaggcc     2700

cggcaggatg agaattacta tttcaccgag gtggagaagg tgctgcagga gaacgacatc     2760

gtggatcacg ccctgaacag caatgagatg gtgtacatca gaaacgtgag cggcagcaca     2820

gaccagaact ccttcaccgg agagatcaag gccaatgatc ccagcttttc tagctccttc     2880

tccgccgagc tgtggggcgt gctgtggctg aacctgtccg aggtgtctaa gtttatcctg     2940

gacgagtctt acagcgtgac atattctgag gtgctggacc ccatcaccgt gtgcaatcgg     3000

atcgaggtgc tgagcgccga gaagcctatg gacctgaccg aggatatcca ggccgtgctg     3060

gactacctgc tgaaccactt tccagataca aagtatctga ccgccaagaa gcagctgccc     3120

ctgatcagca tctacgcctc cgccctgtat ctgcagatca cacggctgtc tcagagatac     3180

gacctgagca cagtgctgac caagtccggc ggactgagcg gcatctccaa gagaggcttt     3240

accaagaagg acttcatgga taggtacaca accggcagca agaagctgat ctggggcaat     3300

ccttatctgc tgaaggagaa gaagaagggc gagggcgaga tcgtgtctgt gctgacaaag     3360

gccagcggca agctgatcat caacctgaat atctccaagg agcaggccag agacctggag     3420

gagaagatcg agaacgccgg cgtgtctagc ttctacctgg gcaagaaggg cctggcctat     3480

gtgaccgata tcaggccatg a                                               3501


<210>  1266
<211>  4806
<212>  DNA
<213>  Vibrio cholerae HE48 vcoHE48.contig.11

<400>  1266
atgggcccca agaagaagag aaaggtaggc tccggcatgg ccaagaacaa tgacatcgcc       60

tctgtgctgg ccttcgagaa gaagctggtg cctagcgatg gctacctgtt tggctgccag      120

tgggagacca aggagcaggc caccccactg acactgcagg agaagagcgt gagaggcaca      180

atctccaaca ggctgaaggc cgccgtgcag aacgaccctg ccaagctgaa tgccgaggtg      240

gagaaggcca atctgcagcg ggtggatgcc tgtgcactgg gacaggacca cgataccctg      300

aagctgcact tcacactgaa ggtgctggga ggcctggccc agccatctgc ctgcaacaat      360

gccctgttta agcagtctta cagcaccgcc gtgagccagt acatcacaaa gtatggctgt      420

ttcgagctgg ccaagagata tgccaccaac ctggccaatg ccaggtttct gtggcggaac      480

agagtgggcg ccgaggagat cgaggtgcag gtgaaggccc tgaacaaggg cgccgagcag      540

acctggacct tcaacgccaa gcagttctct accaggcact ttgaccacaa cgatagccag      600

ctgaattccc tggccgacag gatcgcacag gccctggcca gcgagacaga ccacctgatg      660

ctgcagatcg attgctacgc caaagtgggc aaggcccagg aggtgtatcc ctccgaggag      720

ctggtgctgg ataagggcaa cagcaagacc aagaagtcca agatcctgta cgccgtgaac      780

gagcacgccg ccatgcactc tcagaagatc ggcaatgccc tgcgcagcat cgacacatgg      840

taccctgatt atgcctctga ggagcagagc gccggagcaa tcgcaatcga gccctacggc      900

gccgtgacca atctgggcaa ggccttcaga acccctaagg acaagcagga cttctacacc      960

ttctttgaca agtgggcaag gggagagagc ctgcctaggg aggaggatga gcactacgtg     1020

atggccgtgc tggtgcgggg aggcgtgttc ggagagtccg acaagggctc tggcgaggga     1080

agaggcagcc tgctgacctg tggcgatgtg gaggagaacc ctggacctcc taaaaagaaa     1140

cgaaaggtag gctccggcat gaattactat caggagatca cactgctgcc cgacgcagat     1200

atcgccctgg gcttcctgtg gcagaacgtg tttcagcagg tgcacatcgc cctggtggag     1260

cacaaggtgg cctctaatca gagcctggtg gccgtgggct tccctgacta cagacaggcc     1320

aagtttccac tgggcgccaa gctgaggctg ttcgccaagg agcaggtgac cctggagaag     1380

ctggacatcc acagatggct gacaaggctg gaggattacg tgcacatcaa gggcgtgaag     1440

ccagtgccct ctgacgtgac ctatgtgagc tttgtgagaa agcaggtgaa gtcccccgag     1500

cggatcgaga gagatatgca gcagaaggcc gagctgtggg ccgccaagtc tggcaagcct     1560

ctggtggagt gcctggtgga cctgcagcag tccaagccca ccgccctgtg ctctctgcct     1620

ttcatctacc tgcacagcca gcagacaaag cagaggtctc cagagaagaa cagcaagttt     1680

cccctgttca tcgagatgca gcagcagtcc acatctcagg acggcggctt cgattgctat     1740

ggcctgagct ccaaggccaa tggccagagc atgctggcca ccgtgccaca ctttggctcc     1800

ggcgagggaa ggggctctct gctgacatgt ggcgacgtgg aagaaaaccc tggacctcca     1860

aagaagaaaa gaaaagtcgg ctccggcatg aatgtgctga tcctgcctca cctgaagatc     1920

cacaacgcca atgccctgtc tagccccttt accgtgggct tccctgccat gacagcatgg     1980

ctgggattcg tgcacgccct ggagagaaag ctgtcccagg ccggcctgtc tgatctgatg     2040

ctgcacagca ccgcagtggt gtcccacagg tgcgacgtgc agacacacaa gggcgagggc     2100

gatttcgtgc acagcatcat cggcaccgcc aaccccctgg acaaggatgg cagccgctcc     2160

gcctttatcg aggaggcccg gtgtcacctg gacgtgagcc tggtcatcga gtggtccggc     2220

aatgaggagc aggtgcagca gcctgagttt accgagcagc tgcaggccgt gatcgccaca     2280

atgaaggtgg caggaggcga tgtgctggcc gtgggcaagc cttccgtgaa gtctgtgatc     2340

accgaggacg atacaggcag ggtgctgagg cagctgatgc caggatacgt gctgatcgag     2400

cggagagacc tgatgatcga tgccatgcag cagggcgacg atgcaatcga cgccctgctg     2460

ggctatctga ccgtgcacca ccactgcgag cagctggagg atcagtctgt ggtgtggcac     2520

agccagcgga agacctccgg ctggatcgtg cccatcgcca caggcttcca gggcatctcc     2580

cctctgggcg aggccaagaa ccagagagac cctagcgtgc cacacaggtt cgcagagtcc     2640

gtggtgaccc tgggagagtt tgtgatggtg cacaagatca agcacctgga cgatatcctg     2700

tggcagtacc acccagacct ggagaacgat ctgtatctgt gccagaaggt gaacgccatc     2760

aatgagcacc agggctctgg cgaaggcagg ggcagcctgc tgacatgcgg cgatgtggaa     2820

gagaaccctg gacctcccaa gaaaaagagg aaagtgggcg gctctcagct ggtgaagagc     2880

gagctggagg agaagaagag cgagctgcgg cacaagctga agtacgtgcc tcacgagtat     2940

atcgagctga tcgagatcgc cagaaaccca acccaggaca gaatcctgga gatgaaagtg     3000

atggagttct ttatgaaggt gtacggctat agaggcgagc acctgggcgg ctctaggaag     3060

ccagatggcg ccatctacac cgtgggcagc cccatcgact atggcgtgat cgtggataca     3120

aaggcctact ccggcggcta taatctgcca atcggacagg cagacgagat gcagcggtac     3180

gtggaggaga accagacccg gaataagcac atcaacccca atgagtggtg gaaggtgtac     3240

ccttcctctg tgacagagtt caagtttctg ttcgtgagcg gccacttcaa gggcaactat     3300

aaggcccagc tgaccagact gaatcacatc acaaactgta atggagccgt gctgtccgtg     3360

gaggagctgc tgatcggcgg cgagatgatc aaggccggca ccctgacact ggaggaggtg     3420

aggcgcaagt tcaacaatgg cgagatcaac ttttctgcta gcgagacacc tggcacctcc     3480

gagtctgcca ccccagagtc cggcggctct ggctctagcg gcggctctgg ctcctccgga     3540

ggaatgatcg acccagtgat cgccgccttc tttgccgaga ggaaggaggc ctggctgaag     3600

aagaatatca gcgccgcaat gtccgatgca gaggtgctgg agaagcagca ggagtgcgag     3660

cagaacttcc tgctggacaa ttggctgccc gatgcagcaa agagggcagg acagatctct     3720

gtggccagcc acccatgtac attttcccac ccctctgccc gcaagaacaa gaatggctac     3780

gtgtcctcta tcatcgccaa gaacaagcca cgcatcgacg gcttcctgcg gtctggcaac     3840

gtgagcgtgg agccagacgc cctgggaaat gcagccgccc tggacgtgta caagtttctg     3900

tccctggaga tgtctgatca gcgcagcctg ctggtgcaca tcgagcagga gagcgagctg     3960

gccaggcagc tgctggacat cccttcctgc gagtatcagg ccctgagaga tggcttcctg     4020

aagatggtgg actccgatca ggcctctgtg agctcctcta agatcaagca ggtgtacttt     4080

ccaatcgccg acggcgagta tcacctgctg tccctgctga cccactctgg ccacctgttc     4140

gagctgagga agcgcctgga cgccctgagg tttggcgatg ccgtgaagga ggcccgggag     4200

tgtaagaaga ccaaccactt ccacccagcc ggctaccagg agatcttcgg cctgaccaca     4260

atcggctttg gcggcacaaa gccccagaac atcagcgtgc tgaacaatca gaatgcaggc     4320

aaggcacacc tgctggcctc catcccccct gagctgaccc ctcgggacat cagactgcca     4380

aagacagatt tctttaagga gtccttcaac gcctggcagg ccaaggaggt gctggagtct     4440

ctgcacagac tgtttcagac cgactgcaac aatatcaatc tgagggacgg ccgcgattac     4500

agaatccagc agtatgtgga cctggtcatc gagaagatgt ggcaggtgag gctgttcctg     4560

gaggcctaca gcggcgagct gagctccgcc ctgcctctgg agcagaagat ctggctgtat     4620

ccagagtttg cagagcagag gcagcaggag gacgagtggc tggataagat catccgccac     4680

atcgcccggg gcctgatcaa ccactacagc cggtccaaag tgatcaccaa tcctgtgaca     4740

ctggccgacc aggagctgct ggccatcgag gaggtggtgg cctccaacaa ggagaatctg     4800

agatga                                                                4806


<210>  1267
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Oceanicola sp. HL-35

<400>  1267
ctgttccccg cacacgcggg gatgaaccg                                         29


<210>  1268
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Pseudomonas sp. S-6-2

<400>  1268
gtgttccccg cacctgcggg gatgaaccg                                         29


<210>  1269
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Salmonella enterica subsp. enterica
       serovar Muenster strain

<400>  1269
gtgttccccg cgccagcggg gataaaccg                                         29


<210>  1270
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Atlantibacter hermannii NBRC 105704

<400>  1270
gtgttccccg cgccagcggg gataaaccg                                         29


<210>  1271
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Geothermobacter sp. EPR-M

<400>  1271
ctgttccccg cacccgcggg gatgaaccg                                         29


<210>  1272
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Methylocaldum sp. 14B

<400>  1272
ctgttcccca cgtacgtggg gatgaaccg                                         29


<210>  1273
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Methanocella arvoryzae MRE50

<400>  1273
aaagtcccca caggcgtggg ggtgaaccg                                         29


<210>  1274
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Pseudomonas aeruginosa DHS01

<400>  1274
gtgttcccca catgcgtggg gatgaaccg                                         29


<210>  1275
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Lachnospiraceae bacterium KH1T2

<400>  1275
gtattcccca cgcacgtggg ggtaaatc                                          28


<210>  1276
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Klebsiella pneumoniae strain 
       VRCO0172

<400>  1276
gtattcccca cacgcgtggg ggtgtttc                                          28


<210>  1277
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Streptococcus thermophilus strain 
       ND07

<400>  1277
gtttttcccg cacacgcggg ggtgatcc                                          28


<210>  1278
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Streptomyces sp. S4

<400>  1278
gtcggccccg cacccgcggg gatgctcc                                          28


<210>  1279
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Campylobacter fetus subsp. 
       testudinum Sp3

<400>  1279
gtttgctaat gacaatattt gtgttaaaac                                        30


<210>  1280
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Odoribacter splanchnicus DSM 20712

<400>  1280
cttttaattg aactaaggta gaattgaaac                                        30


<210>  1281
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Bacillus halodurans C-125

<400>  1281
gtcgcactct tcatgggtgc gtggattgaa at                                     32


<210>  1282
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Desulfovibrio vulgaris RCH1 plasmid
       pDEVAL01

<400>  1282
gtcgcccccc acgcgggggc gtggattgaa ac                                     32


<210>  1283
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Geobacillus thermocatenulatus 
       strain KCTC 3921

<400>  1283
gttgcacccg gctattaagc cgggtgagga ttgaaac                                37


<210>  1284
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Vibrio cholerae strain L15 
       L15_contig8

<400>  1284
gttcactgcc gtacaggcag cttagaaa                                          28


<210>  1285
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Pseudomonas aeruginosa UCBPP-PA14

<400>  1285
gttcactgcc gtgtaggcag ctaagaaa                                          28


<210>  1286
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Shewanella putrefaciens CN-32

<400>  1286
gttcaccgcc gcacaggcgg cttagaaa                                          28


<210>  1287
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Acinetobacter sp. 869535

<400>  1287
gttcactgcc atataggcag cttagaaa                                          28


<210>  1288
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CRISPR repeats for Vibrio cholerae HE48 
       vcoHE48.contig.11

<400>  1288
gttcactgcc gcacaggcag cttagaaa                                          28


<210>  1289
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_1

<400>  1289
cgggcaggca gagctggagg cctttcaggc ccctgttccc cgcacacgcg gggatgaacc       60

gggcctgagg tgctgcctgg gcatgtgtaa agg                                    93


<210>  1290
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_2

<400>  1290
tctgtggctg tcgacatgct aagtgagggc ctctgttccc cgcacacgcg gggatgaacc       60

gtagtctcaa gtttgttcaa agctggactc ctc                                    93


<210>  1291
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_3

<400>  1291
atgagtctag gttacattca gtgcaaaaaa ccctgttccc cgcacacgcg gggatgaacc       60

ggtaagtttt taaaatatat atctaccatg tat                                    93


<210>  1292
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_4

<400>  1292
atgattggaa ttatcttcta gctcttgtcg aactgttccc cgcacacgcg gggatgaacc       60

ggtatcaaga ctgtgacttt taattgtagt tta                                    93


<210>  1293
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_5

<400>  1293
acaagttttg ggtctcagcg caggcctcag ttctgttccc cgcacacgcg gggatgaacc       60

gaggtctgtc cagatgctaa gaccaggtac ttc                                    93


<210>  1294
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_6

<400>  1294
gatttcctaa aggaatttaa caacaagacc atctgttccc cgcacacgcg gggatgaacc       60

ggttcctctg tctgatggac ttattcaatg ttt                                    93


<210>  1295
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_7

<400>  1295
tcttagaccc cagccacagg gatatttccc tgctgttccc cgcacacgcg gggatgaacc       60

gttccttcgt catccttgta atccatcagg gtc                                    93


<210>  1296
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_F_8

<400>  1296
atgctgctct tcatctctct tatttaccac tgctgttccc cgcacacgcg gggatgaacc       60

gcaggcaata tctggaactt ctccagtggc ttc                                    93


<210>  1297
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_1

<400>  1297
cctttacaca tgcccaggca gcacctcagg cccggttcat ccccgcgtgt gcggggaaca       60

ggggcctgaa aggcctccag ctctgcctgc ccg                                    93


<210>  1298
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_2

<400>  1298
gaggagtcca gctttgaaca aacttgagac tacggttcat ccccgcgtgt gcggggaaca       60

gaggccctca cttagcatgt cgacagccac aga                                    93


<210>  1299
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_3

<400>  1299
atacatggta gatatatatt ttaaaaactt accggttcat ccccgcgtgt gcggggaaca       60

gggttttttg cactgaatgt aacctagact cat                                    93


<210>  1300
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_4

<400>  1300
taaactacaa ttaaaagtca cagtcttgat accggttcat ccccgcgtgt gcggggaaca       60

gttcgacaag agctagaaga taattccaat cat                                    93


<210>  1301
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_5

<400>  1301
gaagtacctg gtcttagcat ctggacagac ctcggttcat ccccgcgtgt gcggggaaca       60

gaactgaggc ctgcgctgag acccaaaact tgt                                    93


<210>  1302
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_6

<400>  1302
aaacattgaa taagtccatc agacagagga accggttcat ccccgcgtgt gcggggaaca       60

gatggtcttg ttgttaaatt cctttaggaa atc                                    93


<210>  1303
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_7

<400>  1303
gaccctgatg gattacaagg atgacgaagg aacggttcat ccccgcgtgt gcggggaaca       60

gcagggaaat atccctgtgg ctggggtcta aga                                    93


<210>  1304
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_R_8

<400>  1304
gaagccactg gagaagttcc agatattgcc tgcggttcat ccccgcgtgt gcggggaaca       60

gcagtggtaa ataagagaga tgaagagcag cat                                    93


<210>  1305
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_1

<400>  1305
aatcagacca ctcacagcat aggagcagct ctggtattcc ccacacgcgt gggggtgttt       60

cactctgtgc atactctggg gctgggagtt acca                                   94


<210>  1306
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_2

<400>  1306
atttctagcc ttacttccac cttatttctt cccgtattcc ccacacgcgt gggggtgttt       60

caaatagctc ttcagttgtt tctggttaat tgag                                   94


<210>  1307
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_3

<400>  1307
ttctattatg ggatctgtaa cactttattg gatgtattcc ccacacgcgt gggggtgttt       60

ctcattattt ctgcctagag atggatcagg aaat                                   94


<210>  1308
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_4

<400>  1308
aaaataacaa gtttcatgga agaataccca accgtattcc ccacacgcgt gggggtgttt       60

cctttaatga ttgggaatct ggagttaagg gaaa                                   94


<210>  1309
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_5

<400>  1309
tcaccacata gtatgtccct ttaaagcatt gacgtattcc ccacacgcgt gggggtgttt       60

cacaaacttt ctgaacaata caattttaat gcat                                   94


<210>  1310
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_6

<400>  1310
tgacggtgga aacgttctct actacgaagt gatgtattcc ccacacgcgt gggggtgttt       60

catcagtaac atggaagtct caaatatttc agca                                   94


<210>  1311
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_7

<400>  1311
cccttgccct tcttgtggcc cagtggtttt caagtattcc ccacacgcgt gggggtgttt       60

cacgggagag gggaggggag gagttcagag gaag                                   94


<210>  1312
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_F_8

<400>  1312
tcacttgagg tcaggagttc aagaccaccc tgggtattcc ccacacgcgt gggggtgttt       60

cgatactggg ccagatcatt gtttctcaaa ttgc                                   94


<210>  1313
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_1

<400>  1313
aggcctctag gaagacaggt ggaggttagg gatttctaag ctgcctgtgc ggcagtgaac       60

aacctaatta taaggaggtt gttttggcca tg                                     92


<210>  1314
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_2

<400>  1314
cgctctggag ccgcagtgcg cactgcgctg cgtttctaag ctgcctgtgc ggcagtgaac       60

ttattcagga ctgactcccc ctgccagtcc ca                                     92


<210>  1315
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_3

<400>  1315
tatgctcata gcaagatgcc acatgaaaca gttttctaag ctgcctgtgc ggcagtgaac       60

ggctgcgggc ctagaaacaa tagctggtga aa                                     92


<210>  1316
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_4

<400>  1316
attcaggaga tccacattct ctttttagtt tatttctaag ctgcctgtgc ggcagtgaac       60

taatactttt tagctattaa gtaattaaga ta                                     92


<210>  1317
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_5

<400>  1317
cctcagaaca acttcctgaa ggtgatagcg gttttctaag ctgcctgtgc ggcagtgaac       60

gatttgtgga tgccgggttc caactcttct tg                                     92


<210>  1318
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_6

<400>  1318
tgtccatcac tcccataggc tgagtttatt tatttctaag ctgcctgtgc ggcagtgaac       60

caataaatac ttatttagac cttgtgctac ag                                     92


<210>  1319
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_7

<400>  1319
ctgggaccct gatggattac aaggatgacg aatttctaag ctgcctgtgc ggcagtgaac       60

aatatccctg tggctggggt ctaagacttt ga                                     92


<210>  1320
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_R_8

<400>  1320
aatattttgg tcacatgaag aaatatgcaa tatttctaag ctgcctgtgc ggcagtgaac       60

tggcctgtga atggtctcaa ctaacccttt ca                                     92


<210>  1321
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_F_1

<400>  1321
tctggggaat ctgtaaaagg tatatagaaa ctctctgttt gctaatgaca atatttgtgt       60

taaaacaaac aaaaaaacta atctattggt acaatatagt ta                         102


<210>  1322
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_F_2

<400>  1322
gtgttttaaa gttacaccga tacattccag tgccttgttt gctaatgaca atatttgtgt       60

taaaacataa gaaaatcctg ttttctcttt aggacaggaa ct                         102


<210>  1323
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_F_3

<400>  1323
aataatagaa taatggatct tcagtttaca agttttgttt gctaatgaca atatttgtgt       60

taaaacctga tacctaggga atcagtctta tcccccatag ga                         102


<210>  1324
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_R_1

<400>  1324
taactatatt gtaccaatag attagttttt ttgtttgttt taacacaaat attgtcatta       60

gcaaacagag agtttctata taccttttac agattcccca ga                         102


<210>  1325
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_R_2

<400>  1325
agttcctgtc ctaaagagaa aacaggattt tcttatgttt taacacaaat attgtcatta       60

gcaaacaagg cactggaatg tatcggtgta actttaaaac ac                         102


<210>  1326
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_R_3

<400>  1326
tcctatgggg gataagactg attccctagg tatcaggttt taacacaaat attgtcatta       60

gcaaacaaaa cttgtaaact gaagatccat tattctatta tt                         102


<210>  1327
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_F_1

<400>  1327
gtgttttaaa gttacaccga tacattccag tgccttcttt taattgaact aaggtagaat       60

tgaaacataa gaaaatcctg ttttctcttt aggacaggaa ct                         102


<210>  1328
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_F_2

<400>  1328
aataatagaa taatggatct tcagtttaca agttttcttt taattgaact aaggtagaat       60

tgaaacctga tacctaggga atcagtctta tcccccatag ga                         102


<210>  1329
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_R_1

<400>  1329
agttcctgtc ctaaagagaa aacaggattt tcttatgttt caattctacc ttagttcaat       60

taaaagaagg cactggaatg tatcggtgta actttaaaac ac                         102


<210>  1330
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_R_2

<400>  1330
tcctatgggg gataagactg attccctagg tatcaggttt caattctacc ttagttcaat       60

taaaagaaaa cttgtaaact gaagatccat tattctatta tt                         102


<210>  1331
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_1

<400>  1331
atgactttgt aggtgtcttt attgctaggc tgtagtcgca ctcttcatgg gtgcgtggat       60

tgaaattgtt atcatcattt atggagtgtt gccactaacg                            100


<210>  1332
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_2

<400>  1332
caaattattc cattaccaca gcattaatca cacagtcgca ctcttcatgg gtgcgtggat       60

tgaaattgag gaggatacat gtcagatata agttgagatc                            100


<210>  1333
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_3

<400>  1333
tccatcttca gtgcctcaac ttgctttaac aactgtcgca ctcttcatgg gtgcgtggat       60

tgaaatcaat catcttacaa aactggaaac tgaggcatct                            100


<210>  1334
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_4

<400>  1334
tcaccaaata tatgccttcg tgtgtccaaa gtatgtcgca ctcttcatgg gtgcgtggat       60

tgaaattata ttcaagtaat aacacagcat tgcctataca                            100


<210>  1335
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_5

<400>  1335
tttatgagat atttattgga tgaagaaata gagcgtcgca ctcttcatgg gtgcgtggat       60

tgaaatacgg agccagaggc ctaagttcaa ttcttggcac                            100


<210>  1336
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_6

<400>  1336
cacccccaac ccccaccttt cctaaggaca ggtcgtcgca ctcttcatgg gtgcgtggat       60

tgaaataacc cacctcactt actctacatg cagggtccac                            100


<210>  1337
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_F_7

<400>  1337
ttcagagtct ggattgacag ttatttttga aattgtcgca ctcttcatgg gtgcgtggat       60

tgaaatcaag tagctaatga aaggaataat cttgctttag                            100


<210>  1338
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_1

<400>  1338
cgttagtggc aacactccat aaatgatgat aacaatttca atccacgcac ccatgaagag       60

tgcgactaca gcctagcaat aaagacacct acaaagtcat                            100


<210>  1339
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_2

<400>  1339
gatctcaact tatatctgac atgtatcctc ctcaatttca atccacgcac ccatgaagag       60

tgcgactgtg tgattaatgc tgtggtaatg gaataatttg                            100


<210>  1340
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_3

<400>  1340
agatgcctca gtttccagtt ttgtaagatg attgatttca atccacgcac ccatgaagag       60

tgcgacagtt gttaaagcaa gttgaggcac tgaagatgga                            100


<210>  1341
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_4

<400>  1341
tgtataggca atgctgtgtt attacttgaa tataatttca atccacgcac ccatgaagag       60

tgcgacatac tttggacaca cgaaggcata tatttggtga                            100


<210>  1342
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_5

<400>  1342
gtgccaagaa ttgaacttag gcctctggct ccgtatttca atccacgcac ccatgaagag       60

tgcgacgctc tatttcttca tccaataaat atctcataaa                            100


<210>  1343
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_6

<400>  1343
gtggaccctg catgtagagt aagtgaggtg ggttatttca atccacgcac ccatgaagag       60

tgcgacgacc tgtccttagg aaaggtgggg gttgggggtg                            100


<210>  1344
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_R_7

<400>  1344
ctaaagcaag attattcctt tcattagcta cttgatttca atccacgcac ccatgaagag       60

tgcgacaatt tcaaaaataa ctgtcaatcc agactctgaa                            100


<210>  1345
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_F_1

<400>  1345
atgactttgt aggtgtcttt attgctaggc tgtagtcgcc ccccacgcgg gggcgtggat       60

tgaaactgtt atcatcattt atggagtgtt gccactaacg                            100


<210>  1346
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_F_2

<400>  1346
caaattattc cattaccaca gcattaatca cacagtcgcc ccccacgcgg gggcgtggat       60

tgaaactgag gaggatacat gtcagatata agttgagatc                            100


<210>  1347
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_F_3

<400>  1347
tttatgagat atttattgga tgaagaaata gagcgtcgcc ccccacgcgg gggcgtggat       60

tgaaacacgg agccagaggc ctaagttcaa ttcttggcac                            100


<210>  1348
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_F_4

<400>  1348
cacccccaac ccccaccttt cctaaggaca ggtcgtcgcc ccccacgcgg gggcgtggat       60

tgaaacaacc cacctcactt actctacatg cagggtccac                            100


<210>  1349
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_R_1

<400>  1349
cgttagtggc aacactccat aaatgatgat aacagtttca atccacgccc ccgcgtgggg       60

ggcgactaca gcctagcaat aaagacacct acaaagtcat                            100


<210>  1350
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_R_2

<400>  1350
gatctcaact tatatctgac atgtatcctc ctcagtttca atccacgccc ccgcgtgggg       60

ggcgactgtg tgattaatgc tgtggtaatg gaataatttg                            100


<210>  1351
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_R_3

<400>  1351
gtgccaagaa ttgaacttag gcctctggct ccgtgtttca atccacgccc ccgcgtgggg       60

ggcgacgctc tatttcttca tccaataaat atctcataaa                            100


<210>  1352
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_R_4

<400>  1352
gtggaccctg catgtagagt aagtgaggtg ggttgtttca atccacgccc ccgcgtgggg       60

ggcgacgacc tgtccttagg aaaggtgggg gttgggggtg                            100


<210>  1353
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_F_1

<400>  1353
atgactttgt aggtgtcttt attgctaggc tgtacgttgc acccggctat taagccgggt       60

gaggattgaa actgttatca tcatttatgg agtgttgcca ctaacga                    107


<210>  1354
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_F_2

<400>  1354
tccatcttca gtgcctcaac ttgctttaac aactggttgc acccggctat taagccgggt       60

gaggattgaa accaatcatc ttacaaaact ggaaactgag gcatcta                    107


<210>  1355
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_F_3

<400>  1355
tcaccaaata tatgccttcg tgtgtccaaa gtatagttgc acccggctat taagccgggt       60

gaggattgaa actatattca agtaataaca cagcattgcc tatacag                    107


<210>  1356
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_F_4

<400>  1356
cacccccaac ccccaccttt cctaaggaca ggtccgttgc acccggctat taagccgggt       60

gaggattgaa acaacccacc tcacttactc tacatgcagg gtccact                    107


<210>  1357
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_R_1

<400>  1357
tcgttagtgg caacactcca taaatgatga taacagtttc aatcctcacc cggcttaata       60

gccgggtgca acgtacagcc tagcaataaa gacacctaca aagtcat                    107


<210>  1358
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_R_2

<400>  1358
tagatgcctc agtttccagt tttgtaagat gattggtttc aatcctcacc cggcttaata       60

gccgggtgca accagttgtt aaagcaagtt gaggcactga agatgga                    107


<210>  1359
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_R_3

<400>  1359
ctgtataggc aatgctgtgt tattacttga atatagtttc aatcctcacc cggcttaata       60

gccgggtgca actatacttt ggacacacga aggcatatat ttggtga                    107


<210>  1360
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_R_4

<400>  1360
agtggaccct gcatgtagag taagtgaggt gggttgtttc aatcctcacc cggcttaata       60

gccgggtgca acggacctgt ccttaggaaa ggtgggggtt gggggtg                    107


<210>  1361
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_1

<400>  1361
tttcaccagc tattgtttct aggcccgcag ccgttcactg ccgtacaggc agcttagaaa       60

actgtttcat gtggcatctt gctatgagca ta                                     92


<210>  1362
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_2

<400>  1362
tatcttaatt acttaatagc taaaaagtat tagttcactg ccgtacaggc agcttagaaa       60

taaactaaaa agagaatgtg gatctcctga at                                     92


<210>  1363
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_3

<400>  1363
caagaagagt tggaacccgg catccacaaa tcgttcactg ccgtacaggc agcttagaaa       60

accgctatca ccttcaggaa gttgttctga gg                                     92


<210>  1364
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_4

<400>  1364
ctgtagcaca aggtctaaat aagtatttat tggttcactg ccgtacaggc agcttagaaa       60

taaataaact cagcctatgg gagtgatgga ca                                     92


<210>  1365
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_5

<400>  1365
tcaaagtctt agaccccagc cacagggata ttgttcactg ccgtacaggc agcttagaaa       60

ttcgtcatcc ttgtaatcca tcagggtccc ag                                     92


<210>  1366
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_1

<400>  1366
tatgctcata gcaagatgcc acatgaaaca gttttctaag ctgcctgtac ggcagtgaac       60

ggctgcgggc ctagaaacaa tagctggtga aa                                     92


<210>  1367
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_2

<400>  1367
attcaggaga tccacattct ctttttagtt tatttctaag ctgcctgtac ggcagtgaac       60

taatactttt tagctattaa gtaattaaga ta                                     92


<210>  1368
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_3

<400>  1368
cctcagaaca acttcctgaa ggtgatagcg gttttctaag ctgcctgtac ggcagtgaac       60

gatttgtgga tgccgggttc caactcttct tg                                     92


<210>  1369
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_4

<400>  1369
tgtccatcac tcccataggc tgagtttatt tatttctaag ctgcctgtac ggcagtgaac       60

caataaatac ttatttagac cttgtgctac ag                                     92


<210>  1370
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_5

<400>  1370
ctgggaccct gatggattac aaggatgacg aatttctaag ctgcctgtac ggcagtgaac       60

aatatccctg tggctggggt ctaagacttt ga                                     92


<210>  1371
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_1

<400>  1371
tgggactggc agggggagtc agtcctgaat aagttcactg ccgtgtaggc agctaagaaa       60

cgcagcgcag tgcgcactgc ggctccagag cg                                     92


<210>  1372
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_2

<400>  1372
caagaagagt tggaacccgg catccacaaa tcgttcactg ccgtgtaggc agctaagaaa       60

accgctatca ccttcaggaa gttgttctga gg                                     92


<210>  1373
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_3

<400>  1373
ctgtagcaca aggtctaaat aagtatttat tggttcactg ccgtgtaggc agctaagaaa       60

taaataaact cagcctatgg gagtgatgga ca                                     92


<210>  1374
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_F_4

<400>  1374
tgaaagggtt agttgagacc attcacaggc cagttcactg ccgtgtaggc agctaagaaa       60

tattgcatat ttcttcatgt gaccaaaata tt                                     92


<210>  1375
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_1

<400>  1375
cgctctggag ccgcagtgcg cactgcgctg cgtttcttag ctgcctacac ggcagtgaac       60

ttattcagga ctgactcccc ctgccagtcc ca                                     92


<210>  1376
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_2

<400>  1376
cctcagaaca acttcctgaa ggtgatagcg gttttcttag ctgcctacac ggcagtgaac       60

gatttgtgga tgccgggttc caactcttct tg                                     92


<210>  1377
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_3

<400>  1377
tgtccatcac tcccataggc tgagtttatt tatttcttag ctgcctacac ggcagtgaac       60

caataaatac ttatttagac cttgtgctac ag                                     92


<210>  1378
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_R_4

<400>  1378
aatattttgg tcacatgaag aaatatgcaa tatttcttag ctgcctacac ggcagtgaac       60

tggcctgtga atggtctcaa ctaacccttt ca                                     92


<210>  1379
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_F_1

<400>  1379
catggccaaa acaacctcct tataattagg ttgttcaccg ccgcacaggc ggcttagaaa       60

tccctaacct ccacctgtct tcctagaggc ct                                     92


<210>  1380
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_F_2

<400>  1380
ctgtagcaca aggtctaaat aagtatttat tggttcaccg ccgcacaggc ggcttagaaa       60

taaataaact cagcctatgg gagtgatgga ca                                     92


<210>  1381
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_F_3

<400>  1381
tcaaagtctt agaccccagc cacagggata ttgttcaccg ccgcacaggc ggcttagaaa       60

ttcgtcatcc ttgtaatcca tcagggtccc ag                                     92


<210>  1382
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_R_1

<400>  1382
aggcctctag gaagacaggt ggaggttagg gatttctaag ccgcctgtgc ggcggtgaac       60

aacctaatta taaggaggtt gttttggcca tg                                     92


<210>  1383
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_R_2

<400>  1383
tgtccatcac tcccataggc tgagtttatt tatttctaag ccgcctgtgc ggcggtgaac       60

caataaatac ttatttagac cttgtgctac ag                                     92


<210>  1384
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_R_3

<400>  1384
ctgggaccct gatggattac aaggatgacg aatttctaag ccgcctgtgc ggcggtgaac       60

aatatccctg tggctggggt ctaagacttt ga                                     92


<210>  1385
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_F_1

<400>  1385
tgggactggc agggggagtc agtcctgaat aagttcactg ccatataggc agcttagaaa       60

cgcagcgcag tgcgcactgc ggctccagag cg                                     92


<210>  1386
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_F_2

<400>  1386
tttcaccagc tattgtttct aggcccgcag ccgttcactg ccatataggc agcttagaaa       60

actgtttcat gtggcatctt gctatgagca ta                                     92


<210>  1387
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_F_3

<400>  1387
tatcttaatt acttaatagc taaaaagtat tagttcactg ccatataggc agcttagaaa       60

taaactaaaa agagaatgtg gatctcctga at                                     92


<210>  1388
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_F_4

<400>  1388
ctgtagcaca aggtctaaat aagtatttat tggttcactg ccatataggc agcttagaaa       60

taaataaact cagcctatgg gagtgatgga ca                                     92


<210>  1389
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_F_5

<400>  1389
tcaaagtctt agaccccagc cacagggata ttgttcactg ccatataggc agcttagaaa       60

ttcgtcatcc ttgtaatcca tcagggtccc ag                                     92


<210>  1390
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_F_6

<400>  1390
tgaaagggtt agttgagacc attcacaggc cagttcactg ccatataggc agcttagaaa       60

tattgcatat ttcttcatgt gaccaaaata tt                                     92


<210>  1391
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_R_1

<400>  1391
cgctctggag ccgcagtgcg cactgcgctg cgtttctaag ctgcctatat ggcagtgaac       60

ttattcagga ctgactcccc ctgccagtcc ca                                     92


<210>  1392
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_R_2

<400>  1392
tatgctcata gcaagatgcc acatgaaaca gttttctaag ctgcctatat ggcagtgaac       60

ggctgcgggc ctagaaacaa tagctggtga aa                                     92


<210>  1393
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_R_3

<400>  1393
attcaggaga tccacattct ctttttagtt tatttctaag ctgcctatat ggcagtgaac       60

taatactttt tagctattaa gtaattaaga ta                                     92


<210>  1394
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_R_4

<400>  1394
tgtccatcac tcccataggc tgagtttatt tatttctaag ctgcctatat ggcagtgaac       60

caataaatac ttatttagac cttgtgctac ag                                     92


<210>  1395
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_R_5

<400>  1395
ctgggaccct gatggattac aaggatgacg aatttctaag ctgcctatat ggcagtgaac       60

aatatccctg tggctggggt ctaagacttt ga                                     92


<210>  1396
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_R_6

<400>  1396
aatattttgg tcacatgaag aaatatgcaa tatttctaag ctgcctatat ggcagtgaac       60

tggcctgtga atggtctcaa ctaacccttt ca                                     92


<210>  1397
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_F_1

<400>  1397
tgggactggc agggggagtc agtcctgaat aagttcactg ccgcacaggc agcttagaaa       60

cgcagcgcag tgcgcactgc ggctccagag cg                                     92


<210>  1398
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_F_2

<400>  1398
tgaaagggtt agttgagacc attcacaggc cagttcactg ccgcacaggc agcttagaaa       60

tattgcatat ttcttcatgt gaccaaaata tt                                     92


<210>  1399
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_R_1

<400>  1399
cgctctggag ccgcagtgcg cactgcgctg cgtttctaag ctgcctgtgc ggcagtgaac       60

ttattcagga ctgactcccc ctgccagtcc ca                                     92


<210>  1400
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_R_2

<400>  1400
aatattttgg tcacatgaag aaatatgcaa tatttctaag ctgcctgtgc ggcagtgaac       60

tggcctgtga atggtctcaa ctaacccttt ca                                     92


<210>  1401
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_1

<400>  1401
cactctttcc ctacacgacg ctcttccgat ctttcctccc taacctccac ct               52


<210>  1402
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_2

<400>  1402
cactctttcc ctacacgacg ctcttccgat ctctaggttg gcagcgaatg ag               52


<210>  1403
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_3

<400>  1403
cactctttcc ctacacgacg ctcttccgat ctccactgtt tcatgtggca tc               52


<210>  1404
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_4

<400>  1404
cactctttcc ctacacgacg ctcttccgat cttgaggcac tgaagatgga ga               52


<210>  1405
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_5

<400>  1405
cactctttcc ctacacgacg ctcttccgat cttttggaca cacgaaggca ta               52


<210>  1406
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_6

<400>  1406
cactctttcc ctacacgacg ctcttccgat cttcaggtca tgcgtggaca                  50


<210>  1407
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_7

<400>  1407
cactctttcc ctacacgacg ctcttccgat ctcaagggtt cttctcaacc ca               52


<210>  1408
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_F_8

<400>  1408
cactctttcc ctacacgacg ctcttccgat ctctttgcca cgtatttcta gcct             54


<210>  1409
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_1

<400>  1409
ggagttcaga cgtgtgctct tccgatctta aagagcccaa ccagatgc                    48


<210>  1410
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_2

<400>  1410
ggagttcaga cgtgtgctct tccgatctga caaatctcca gctgctcc                    48


<210>  1411
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_3

<400>  1411
ggagttcaga cgtgtgctct tccgatcttt ggtaaaaggg caacaatg                    48


<210>  1412
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_4

<400>  1412
ggagttcaga cgtgtgctct tccgatcttc aagtttacaa gagggaatac tgaa             54


<210>  1413
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_5

<400>  1413
ggagttcaga cgtgtgctct tccgatctct aactgccctg gagacctg                    48


<210>  1414
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_6

<400>  1414
ggagttcaga cgtgtgctct tccgatcttt ggcaacatgt ggattcat                    48


<210>  1415
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_7

<400>  1415
ggagttcaga cgtgtgctct tccgatctga gaggcacgag aacacaca                    48


<210>  1416
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set1_ilmn_R_8

<400>  1416
ggagttcaga cgtgtgctct tccgatcttt gcattgaaag tctctttagg tg               52


<210>  1417
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_1

<400>  1417
cactctttcc ctacacgacg ctcttccgat ctaatgccct tctctcttgc ct               52


<210>  1418
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_2

<400>  1418
cactctttcc ctacacgacg ctcttccgat ctacgtcaca aagcgagtga ga               52


<210>  1419
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_3

<400>  1419
cactctttcc ctacacgacg ctcttccgat ctgatatagc gtctggtatc aaggg            55


<210>  1420
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_4

<400>  1420
cactctttcc ctacacgacg ctcttccgat cttttggatt agggaggtat ggc              53


<210>  1421
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_5

<400>  1421
cactctttcc ctacacgacg ctcttccgat ctactgtgct ttaaacattt gtctgtg          57


<210>  1422
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_6

<400>  1422
cactctttcc ctacacgacg ctcttccgat ctttccaaga ttcccagtca cc               52


<210>  1423
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_7

<400>  1423
cactctttcc ctacacgacg ctcttccgat ctgctgttca acccacctca ct               52


<210>  1424
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_F_8

<400>  1424
cactctttcc ctacacgacg ctcttccgat ctccaccacg cctgactaat tt               52


<210>  1425
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_1

<400>  1425
ggagttcaga cgtgtgctct tccgatctga tggaagacag gcttctcg                    48


<210>  1426
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_2

<400>  1426
ggagttcaga cgtgtgctct tccgatctgg gcttgtttct tccttcct                    48


<210>  1427
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_3

<400>  1427
ggagttcaga cgtgtgctct tccgatctcc ctactttcca atcaaggct                   49


<210>  1428
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_4

<400>  1428
ggagttcaga cgtgtgctct tccgatctgg gcaagatgag cagagact                    48


<210>  1429
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_5

<400>  1429
ggagttcaga cgtgtgctct tccgatctaa gctgttggcc tatctgga                    48


<210>  1430
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_6

<400>  1430
ggagttcaga cgtgtgctct tccgatctca tttgtgacag cagcgtg                     47


<210>  1431
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_7

<400>  1431
ggagttcaga cgtgtgctct tccgatctcc cagccacagg gatattt                     47


<210>  1432
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set2_ilmn_R_8

<400>  1432
ggagttcaga cgtgtgctct tccgatctaa ataagtttca caactatgaa caggtc           56


<210>  1433
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_ilmn_F_1

<400>  1433
cactctttcc ctacacgacg ctcttccgat ctttggactt acagaagagt tggaaa           56


<210>  1434
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_ilmn_F_2

<400>  1434
cactctttcc ctacacgacg ctcttccgat ctgtgtattt gggagggaag ca               52


<210>  1435
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_ilmn_F_3

<400>  1435
cactctttcc ctacacgacg ctcttccgat ctaaatcgaa atgggattca cg               52


<210>  1436
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_ilmn_R_1

<400>  1436
cactctttcc ctacacgacg ctcttccgat ctgtgtattt gggagggaag ca               52


<210>  1437
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_ilmn_R_2

<400>  1437
cactctttcc ctacacgacg ctcttccgat ctaaatcgaa atgggattca cg               52


<210>  1438
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set3_ilmn_R_3

<400>  1438
cactctttcc ctacacgacg ctcttccgat ctggcgattc acacaactga aa               52


<210>  1439
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_ilmn_F_1

<400>  1439
cactctttcc ctacacgacg ctcttccgat ctaaagattt gcctgcgtga at               52


<210>  1440
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_ilmn_F_2

<400>  1440
cactctttcc ctacacgacg ctcttccgat cttaggtcca agggtagcca ag               52


<210>  1441
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_ilmn_R_1

<400>  1441
cactctttcc ctacacgacg ctcttccgat ctatccgtga cactacatgc ca               52


<210>  1442
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set4_ilmn_R_2

<400>  1442
cactctttcc ctacacgacg ctcttccgat ctcccatgct cttaagccac tc               52


<210>  1443
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_1

<400>  1443
cactctttcc ctacacgacg ctcttccgat ctaccatttg gccagagtcc ta               52


<210>  1444
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_2

<400>  1444
cactctttcc ctacacgacg ctcttccgat ctgcatcacc ttcaagaaag gtaca            55


<210>  1445
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_3

<400>  1445
cactctttcc ctacacgacg ctcttccgat ctggcgattc acacaactga aa               52


<210>  1446
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_4

<400>  1446
cactctttcc ctacacgacg ctcttccgat ctaaagattt gcctgcgtga at               52


<210>  1447
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_5

<400>  1447
cactctttcc ctacacgacg ctcttccgat ctcccatgct cttaagccac tc               52


<210>  1448
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_6

<400>  1448
cactctttcc ctacacgacg ctcttccgat ctaccatttg gccagagtcc ta               52


<210>  1449
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_F_7

<400>  1449
cactctttcc ctacacgacg ctcttccgat ctaggcttgt ccctggtaac ct               52


<210>  1450
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_1

<400>  1450
cactctttcc ctacacgacg ctcttccgat cttaggtcca agggtagcca ag               52


<210>  1451
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_2

<400>  1451
cactctttcc ctacacgacg ctcttccgat ctatccgtga cactacatgc ca               52


<210>  1452
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_3

<400>  1452
cactctttcc ctacacgacg ctcttccgat ctaccatttg gccagagtcc ta               52


<210>  1453
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_4

<400>  1453
cactctttcc ctacacgacg ctcttccgat ctttgttccc agtgttggtt ga               52


<210>  1454
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_5

<400>  1454
cactctttcc ctacacgacg ctcttccgat cttggatttc atattacaga ggcattt          57


<210>  1455
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_6

<400>  1455
cactctttcc ctacacgacg ctcttccgat ctgtggacta gcacttggct cc               52


<210>  1456
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set5_ilmn_R_7

<400>  1456
cactctttcc ctacacgacg ctcttccgat ctttggcaca tggtaaacac tca              53


<210>  1457
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_F_1

<400>  1457
cactctttcc ctacacgacg ctcttccgat ctcaagggtt cttctcaacc ca               52


<210>  1458
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_F_2

<400>  1458
cactctttcc ctacacgacg ctcttccgat ctggaaatcg accaaagacg ag               52


<210>  1459
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_F_3

<400>  1459
cactctttcc ctacacgacg ctcttccgat ctgtggacta gcacttggct cc               52


<210>  1460
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_F_4

<400>  1460
cactctttcc ctacacgacg ctcttccgat ctttggcaca tggtaaacac tca              53


<210>  1461
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_R_1

<400>  1461
cactctttcc ctacacgacg ctcttccgat ctcagaagcc ctttgagagt gg               52


<210>  1462
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_R_2

<400>  1462
cactctttcc ctacacgacg ctcttccgat ctaggcaaat agaattgggc tg               52


<210>  1463
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_R_3

<400>  1463
cactctttcc ctacacgacg ctcttccgat ctttggcaca tggtaaacac tca              53


<210>  1464
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set6_ilmn_R_4

<400>  1464
cactctttcc ctacacgacg ctcttccgat ctcaagggtt cttctcaacc ca               52


<210>  1465
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_F_1

<400>  1465
cactctttcc ctacacgacg ctcttccgat ctggaaatcg accaaagacg ag               52


<210>  1466
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_F_2

<400>  1466
cactctttcc ctacacgacg ctcttccgat ctttgttccc agtgttggtt ga               52


<210>  1467
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_F_3

<400>  1467
cactctttcc ctacacgacg ctcttccgat cttggatttc atattacaga ggcattt          57


<210>  1468
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_F_4

<400>  1468
cactctttcc ctacacgacg ctcttccgat ctttggcaca tggtaaacac tca              53


<210>  1469
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_R_1

<400>  1469
cactctttcc ctacacgacg ctcttccgat ctcaagggtt cttctcaacc ca               52


<210>  1470
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_R_2

<400>  1470
cactctttcc ctacacgacg ctcttccgat ctcagaagcc ctttgagagt gg               52


<210>  1471
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_R_3

<400>  1471
cactctttcc ctacacgacg ctcttccgat ctggaaatcg accaaagacg ag               52


<210>  1472
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set7_ilmn_R_4

<400>  1472
cactctttcc ctacacgacg ctcttccgat ctcagaagcc ctttgagagt gg               52


<210>  1473
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_1

<400>  1473
ggagttcaga cgtgtgctct tccgatctgc agggagtaaa ccaacaaca                   49


<210>  1474
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_2

<400>  1474
ggagttcaga cgtgtgctct tccgatctgg atctggtgat gagaggga                    48


<210>  1475
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_3

<400>  1475
ggagttcaga cgtgtgctct tccgatctcc attcggctct gacagataa                   49


<210>  1476
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_4

<400>  1476
ggagttcaga cgtgtgctct tccgatctgg atctggtgat gagaggga                    48


<210>  1477
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_5

<400>  1477
ggagttcaga cgtgtgctct tccgatctcc attcggctct gacagataa                   49


<210>  1478
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_1

<400>  1478
ggagttcaga cgtgtgctct tccgatctca ggtagtgtgc agcctcaa                    48


<210>  1479
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_2

<400>  1479
ggagttcaga cgtgtgctct tccgatctgg ttcagaactt gagcaggg                    48


<210>  1480
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_3

<400>  1480
ggagttcaga cgtgtgctct tccgatcttc aagtttacaa gagggaatac tgaa             54


<210>  1481
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_4

<400>  1481
ggagttcaga cgtgtgctct tccgatctgc tcttcgtagt ggtgcattt                   49


<210>  1482
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_5

<400>  1482
ggagttcaga cgtgtgctct tccgatctaa gaaatttgcc caaggtcat                   49


<210>  1483
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_1

<400>  1483
ggagttcaga cgtgtgctct tccgatcttg gaacacaatg ggttgaga                    48


<210>  1484
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_2

<400>  1484
ggagttcaga cgtgtgctct tccgatcttg ggttcgttta cacaagtcaa                  50


<210>  1485
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_3

<400>  1485
ggagttcaga cgtgtgctct tccgatctca ggtagtgtgc agcctcaa                    48


<210>  1486
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_F_4

<400>  1486
ggagttcaga cgtgtgctct tccgatctgg ttcagaactt gagcaggg                    48


<210>  1487
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_1

<400>  1487
ggagttcaga cgtgtgctct tccgatctaa gaaatttgcc caaggtcat                   49


<210>  1488
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_2

<400>  1488
ggagttcaga cgtgtgctct tccgatcttg gaacacaatg ggttgaga                    48


<210>  1489
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_3

<400>  1489
ggagttcaga cgtgtgctct tccgatctgc atcaaagcca ggaatctc                    48


<210>  1490
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set8_ilmn_R_4

<400>  1490
ggagttcaga cgtgtgctct tccgatcttc aagtttacaa gagggaatac tgaa             54


<210>  1491
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_ilmn_F_1

<400>  1491
ggagttcaga cgtgtgctct tccgatctgc tcttcgtagt ggtgcattt                   49


<210>  1492
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_ilmn_F_2

<400>  1492
ggagttcaga cgtgtgctct tccgatcttg gaacacaatg ggttgaga                    48


<210>  1493
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_ilmn_F_3

<400>  1493
ggagttcaga cgtgtgctct tccgatctac aagcccgtga agatgagt                    48


<210>  1494
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_ilmn_R_1

<400>  1494
ggagttcaga cgtgtgctct tccgatctgc caggtaagag gactttagga a                51


<210>  1495
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_ilmn_R_2

<400>  1495
ggagttcaga cgtgtgctct tccgatcttc tctgatgaag acccaggc                    48


<210>  1496
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set9_ilmn_R_3

<400>  1496
ggagttcaga cgtgtgctct tccgatcttt cccgtgtcac atagcgta                    48


<210>  1497
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnF_1

<400>  1497
ggagttcaga cgtgtgctct tccgatctga gaggcacgag aacacaca                    48


<210>  1498
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnF_2

<400>  1498
ggagttcaga cgtgtgctct tccgatctag cacgtttaga atctggcg                    48


<210>  1499
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnF_3

<400>  1499
ggagttcaga cgtgtgctct tccgatcttc tctgatgaag acccaggc                    48


<210>  1500
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnF_4

<400>  1500
ggagttcaga cgtgtgctct tccgatcttt cccgtgtcac atagcgta                    48


<210>  1501
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnF_5

<400>  1501
ggagttcaga cgtgtgctct tccgatctag gctagaaata cgtggcaaag                  50


<210>  1502
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnF_6

<400>  1502
ggagttcaga cgtgtgctct tccgatcttg gcttcacagt gagcgtag                    48


<210>  1503
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnR_1

<400>  1503
ggagttcaga cgtgtgctct tccgatcttt cccgtgtcac atagcgta                    48


<210>  1504
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnR_2

<400>  1504
ggagttcaga cgtgtgctct tccgatctga gaggcacgag aacacaca                    48


<210>  1505
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnR_3

<400>  1505
ggagttcaga cgtgtgctct tccgatctag cacgtttaga atctggcg                    48


<210>  1506
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnR_4

<400>  1506
ggagttcaga cgtgtgctct tccgatctac aagcccgtga agatgagt                    48


<210>  1507
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnR_5

<400>  1507
ggagttcaga cgtgtgctct tccgatctgc caggtaagag gactttagga a                51


<210>  1508
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set10_ilmnR_6

<400>  1508
ggagttcaga cgtgtgctct tccgatcttt cccgtgtcac atagcgta                    48


<210>  1509
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_ilmnF_1

<400>  1509
ggagttcaga cgtgtgctct tccgatctga gaggcacgag aacacaca                    48


<210>  1510
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_ilmnF_2

<400>  1510
ggagttcaga cgtgtgctct tccgatctag gctagaaata cgtggcaaag                  50


<210>  1511
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_ilmnR_1

<400>  1511
ggagttcaga cgtgtgctct tccgatctag cacgtttaga atctggcg                    48


<210>  1512
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: homolog screen target set11_ilmnR_2

<400>  1512
ggagttcaga cgtgtgctct tccgatctag gctagaaata cgtggcaaag                  50


<210>  1513
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: oCB5714

<400>  1513
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tg                                                82


<210>  1514
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: oCB5715

<400>  1514
gctgttagag agataattgg aattaatttg actgtaaaca caaagatatt agtacaaaat       60

acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa      120

atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc      180

ttgtggaaag gacgaaacac                                                  200


<210>  1515
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: oCB5717

<400>  1515
gccccagctg gttctttccg                                                   20


<210>  1516
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa345_Pseud

<400>  1516
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgtactc       60

gtcggcatcc accacgtcgt ccatgtcggt tcatccccgc aggtgcgggg aacacagaat      120

gcatttgcca agtcctacag actccaacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1517
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa346_Pseud

<400>  1517
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccgctt       60

cccctctcag gccagcttcc ctaaggcggt tcatccccgc aggtgcgggg aacacgggtc      120

cagtggatgc cacagcccag cttggcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1518
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa347_Pseud

<400>  1518
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccgctt       60

cccctctcag gccagcttcc ctaaggcggt tcatccccgc aggtgcgggg aacacgggtc      120

cagtggatgc cacagcccag cttggcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1519
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa348_Pseud

<400>  1519
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaagtgc       60

ttggtgaggg cttccagcag ctcctgcggt tcatccccgc aggtgcgggg aacaccactg      120

tgcccatgct gaaagaggcc tgccgggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1520
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa349_Pseud

<400>  1520
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacacat       60

gcttttaaga aacgtcaatg tatatccggt tcatccccgc aggtgcgggg aacacgcata      120

cagcattcaa aaccagtgct ggaatagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1521
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa350_Pseud

<400>  1521
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactgctgg       60

gaattccaac catccaatcg gacaagcggt tcatccccgc aggtgcgggg aacacaaatg      120

ttattcatgc ttcttatttt aaaagtgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1522
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa351_Pseud

<400>  1522
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactctaaa       60

tataaaagag gactgcaatg ccatggcggt tcatccccgc aggtgcgggg aacacggctc      120

aggggcctcc aggttcacct cagtcttcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1523
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa352_Pseud

<400>  1523
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgcatgt       60

ttggtaaaaa tgtttttgtg agagttcggt tcatccccgc aggtgcgggg aacacactta      120

aaaattttta aatgccctta aaagtgacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1524
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa353_Pseud

<400>  1524
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacctggct       60

gcacaaacac cttctcgttt cagagtcggt tcatccccgc aggtgcgggg aacacgtgtt      120

ttatttttca tgtagtgtgc tccaccacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1525
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa354_Pseud

<400>  1525
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagtcac       60

ctgaattttc tggtcatcca actcttcggt tcatccccgc aggtgcgggg aacacgtgca      120

gatacacacc ccgcaggaac atccctccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1526
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa355_Pseud

<400>  1526
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactggcat       60

gaggaggggg aagctttttt gaatcgcggt tcatccccgc aggtgcgggg aacacaatga      120

attgatttcc ataaagcaaa tcttactcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1527
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa356_Pseud

<400>  1527
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgcagcc       60

tctagagcct tcttgctttc attttccggt tcatccccgc aggtgcgggg aacactagct      120

ttgggtttca ggcacttcag taagagacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1528
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa357_Pseud

<400>  1528
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacttttgt       60

ttcctgaaat tatcacatct ccatcacggt tcatccccgc aggtgcgggg aacactctct      120

tgcagtcgtc agcctgaaca taacatccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1529
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa358_Pseud

<400>  1529
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagtcac       60

ctgaattttc tggtcatcca actcttcggt tcatccccgc aggtgcgggg aacacgtgca      120

gatacacacc ccgcaggaac atccctccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1530
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa359_Pseud

<400>  1530
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccagact       60

tttataatct ccagtggcat ctttcccggt tcatccccgc aggtgcgggg aacactattc      120

atctttgcca gtctatcaaa tctgctgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1531
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa360_Pseud

<400>  1531
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgatgca       60

gaaaaggtag actggggcca ctgggtcggt tcatccccgc aggtgcgggg aacaccttcc      120

tggcagggat gtcagaccca gccttggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1532
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa361_Pseud

<400>  1532
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccgcaat       60

acaggaaccc ccaggggaaa gatgagcggt tcatccccgc aggtgcgggg aacacaaaat      120

acagggaaga aacggtaaaa atcaaagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1533
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa362_Pseud

<400>  1533
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacacat       60

tcggctccct ggagccagac tctggtcggt tcatccccgc aggtgcgggg aacaccgatt      120

gttcctggga gcttctccag accttggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1534
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa363_Pseud

<400>  1534
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccctcct       60

tcccaggtcc tccagccctt ctgcgacggt tcatccccgc aggtgcgggg aacactgctc      120

tccggccggg ccaacgcgcg gggcctgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1535
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa364_Pseud

<400>  1535
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccgtga       60

aatgggttgt gggccaaagc tttcttcggt tcatccccgc aggtgcgggg aacactgtat      120

ttttcagtaa tggcaatgca gatgcagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1536
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa365_Pseud

<400>  1536
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactctccc       60

tagagatata atttagatat tcctatcggt tcatccccgc aggtgcgggg aacacggtgt      120

aaccactgcc aataggctgt ttctatgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1537
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa366_Pseud

<400>  1537
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggagtt       60

gccatgattt tttcagtaaa gggcatcggt tcatccccgc aggtgcgggg aacacattta      120

tctcctttct tcaggcttcc agctggtcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1538
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa367_Pseud

<400>  1538
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccttctc       60

accgtgtttt ctcttggtaa ctttcccggt tcatccccgc aggtgcgggg aacacgactg      120

ggctccttgg tggatgagtt taaggagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1539
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa368_Pseud

<400>  1539
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactccctc       60

tcctgcagca gcctccgcag cgtgcgcggt tcatccccgc aggtgcgggg aacacttgct      120

gctggtggtg gccctgggga tcggcctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1540
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa369_Pseud

<400>  1540
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacctca       60

gagtatgttc tgctgcttga actttacggt tcatccccgc aggtgcgggg aacacatgac      120

aaggtggaac tagccaatat gaatagacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1541
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa370_Pseud

<400>  1541
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccattta       60

cctcagagta tgttctgctg cttgaacggt tcatccccgc aggtgcgggg aacacaaggt      120

ggaactagcc aatatgaata gacttttcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1542
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa371_Pseud

<400>  1542
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacatactt       60

tatcaaattg taaaatttta taaaaccggt tcatccccgc aggtgcgggg aacacaaatg      120

aaatgcagtt tttcaaaaat aaatttccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1543
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa372_Pseud

<400>  1543
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgtaaat       60

atttttaaaa ttcactgaat ttttgtcggt tcatccccgc aggtgcgggg aacacatcag      120

taagatcata agcagtgatc gagatctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1544
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa373_Pseud

<400>  1544
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacctattc       60

aacctcctta catgtcaggt ccactgcggt tcatccccgc aggtgcgggg aacacgtgct      120

gcagcagcac ttcaggaacc tggaggccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1545
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa374_Pseud

<400>  1545
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccttca       60

cacaaaagaa cagtatatag tacaaacggt tcatccccgc aggtgcgggg aacacggtga      120

tggtgtagcc ctcccacttt gctgttccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1546
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa375_Pseud

<400>  1546
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgtagag       60

cagcatccag aaagtctgtt attcctcggt tcatccccgc aggtgcgggg aacacaacac      120

tgatacccca aaataggatt ttccttccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1547
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa376_Pseud

<400>  1547
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactcccag       60

catgctctgg ggaggcggct ctggctcggt tcatccccgc aggtgcgggg aacacaaata      120

aacaaaagaa agaaaagaaa aatagcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1548
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa377_Pseud

<400>  1548
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccattcg       60

gctccctgga gccagactct ggtcttcggt tcatccccgc aggtgcgggg aacacgccat      120

cgattgttcc tgggagcttc tccagaccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1549
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa378_Pseud

<400>  1549
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaagtca       60

cgcgcagtag aacatgaacg gcgcagcggt tcatccccgc aggtgcgggg aacacgatca      120

taaagacact gttctccctt caagttccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1550
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa379_Pseud

<400>  1550
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagtttg       60

gtgcgaacgc cattctgggg gtgtcccggt tcatccccgc aggtgcgggg aacacaagtc      120

agcgatgtgg cggtacaggg ggacccccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1551
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa380_Pseud

<400>  1551
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacctaaag       60

gtaccctcag tgtcaatgta catggccggt tcatccccgc aggtgcgggg aacacttcat      120

ttctactgtt gtttttgttc tctatagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1552
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa381_Pseud

<400>  1552
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacttgg       60

aaagggttta tcatacctca tagtcgcggt tcatccccgc aggtgcgggg aacaccttta      120

aaacatattt ttctttgttt taagccgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1553
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa382_Pseud

<400>  1553
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccataaa       60

taagtttcca ggctaaaaaa actatccggt tcatccccgc aggtgcgggg aacactagtt      120

ttgagatgct aggattatac tgtgattcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1554
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa383_Pseud

<400>  1554
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaggagt       60

cacctgaatt ttctggtcat ccaactcggt tcatccccgc aggtgcgggg aacacgtgca      120

gatacacacc ccgcaggaac atccctccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1555
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa384_Pseud

<400>  1555
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccccaac       60

cccaggcagc ctctagagcc ttcttgcggt tcatccccgc aggtgcgggg aacacggttt      120

caggcacttc agtaagagac tttcccccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1556
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa385_Pseud

<400>  1556
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactttcat       60

cccagggttc tctcctctcc tcacagcggt tcatccccgc aggtgcgggg aacacgccaa      120

atccttgcgt agcccgaagc ggtggcacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1557
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa386_Pseud

<400>  1557
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccccag       60

cgcctatctt tctcctttgg ggaccacggt tcatccccgc aggtgcgggg aacaccccga      120

tccactaggg atgcactcac cgctggccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1558
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa387_Pseud

<400>  1558
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgttttc       60

actccagcta acacagatgt aaaagacggt tcatccccgc aggtgcgggg aacactggtc      120

agtcttttat atctgaaaaa tgtgtaacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1559
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa388_Pseud

<400>  1559
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgttgta       60

ggattctaca ttaattctct tgtgcccggt tcatccccgc aggtgcgggg aacacttaaa      120

gcaatttaaa aaaccaattc aggcttgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1560
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa389_Pseud

<400>  1560
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacctcctt       60

tccttagtgg tgtctatcga agatcccggt tcatccccgc aggtgcgggg aacaccccac      120

tacctggatt cctgcactgg ctgtgaacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1561
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa390_Pseud

<400>  1561
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgtcatc       60

ggcatggacg tagcggcctc cgagttcggt tcatccccgc aggtgcgggg aacacggcga      120

gatgtacctg ctggggtcat cgggagacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1562
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa391_Pseud

<400>  1562
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactaaccg       60

tgaaatgggt tgtgggccaa agctttcggt tcatccccgc aggtgcgggg aacactgtat      120

ttttcagtaa tggcaatgca gatgcagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1563
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa392_Pseud

<400>  1563
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgggttg       60

tcttcattgg tgaacagcat gatcctcggt tcatccccgc aggtgcgggg aacacctcag      120

tgaagtgctg tgggtctgtg ccaacctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1564
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa393_Pseud

<400>  1564
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacttagaa       60

aaataacagt ggagagcaca gcttcacggt tcatccccgc aggtgcgggg aacactcctt      120

tcccctgtgt gggataatct ctcccagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1565
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa394_Pseud

<400>  1565
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagttct       60

agtctctctg gggccacaca gaaactcggt tcatccccgc aggtgcgggg aacacagctc      120

caagacctgg tcccatggtc ctgcctacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1566
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa395_Pseud

<400>  1566
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggaggg       60

tgctttgttc cttctgcaga gtcgtgcggt tcatccccgc aggtgcgggg aacacggggc      120

cggcccaggc ctagggtgtg gaggagccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1567
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa396_Pseud

<400>  1567
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgctctg       60

caaccaggag cccagtgggg agggtgcggt tcatccccgc aggtgcgggg aacacggagg      120

agccttgcca tcgggcttcc tgtctctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1568
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa397_Pseud

<400>  1568
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacattaat       60

atccttgtac ttacctgtca caaatacggt tcatccccgc aggtgcgggg aacacccaga      120

tatgaccatg tatttgtggc ttaaactcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1569
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa398_Pseud

<400>  1569
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaatgcc       60

cactgacctg gtggtgggta gctgctcggt tcatccccgc aggtgcgggg aacacagaat      120

ctctgcccat gagaactctg aggcctccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1570
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa399_Pseud

<400>  1570
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactccttc       60

tccctgtatc tgaggatcat atactacggt tcatccccgc aggtgcgggg aacactgatc      120

ctgtaatctt tttctttcca gtaatcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1571
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa400_Pseud

<400>  1571
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acaccgaaca       60

acacaaatgg ataacggccc gcttaccggt tcatccccgc aggtgcgggg aacacagtac      120

agggcccgcg catgcgtgga ttgtcgtcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1572
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa401_Pseud

<400>  1572
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacatgtaa       60

aagacttttt tttatacgat aaataacggt tcatccccgc aggtgcgggg aacaccaagc      120

aataaaaact gtacaatatt ggtcagtcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1573
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa402_Pseud

<400>  1573
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagcttg       60

ggcagccacc tccttaggtg ttagtgcggt tcatccccgc aggtgcgggg aacacacagc      120

ggtaaataca gaacagaaaa taaccatcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1574
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa403_Pseud

<400>  1574
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggcggt       60

gggggaagac ttaaccgagt tgccgtcggt tcatccccgc aggtgcgggg aacacgggag      120

atgtagtccc gggccgacgc attacctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1575
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa404_Pseud

<400>  1575
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactggcat       60

gaggaggggg aagctttttt gaatcgcggt tcatccccgc aggtgcgggg aacactttat      120

taatgaattg atttccataa agcaaatcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1576
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa405_Pseud

<400>  1576
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgtagag       60

cagcatccag aaagtctgtt attcctcggt tcatccccgc aggtgcgggg aacacgtcaa      120

acactgatac cccaaaatag gattttccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1577
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa406_Pseud

<400>  1577
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccgctt       60

cccctctcag gccagcttcc ctaaggcggt tcatccccgc aggtgcgggg aacacgactc      120

tagggtccag tggatgccac agcccagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1578
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa407_Pseud

<400>  1578
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccgctt       60

cccctctcag gccagcttcc ctaaggcggt tcatccccgc aggtgcgggg aacacgactc      120

tagggtccag tggatgccac agcccagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1579
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa408_Pseud

<400>  1579
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacaaaa       60

cataccctat caatggcact gcccttcggt tcatccccgc aggtgcgggg aacacttgtg      120

tcctggctaa atcagaactc gaatggccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1580
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa409_Pseud

<400>  1580
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggccac       60

cctggatggg agccgtgttc attacccggt tcatccccgc aggtgcgggg aacactgggg      120

ctggatatgg gtgagaacct ggagccgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1581
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa410_Pseud

<400>  1581
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactggaca       60

ttcatctgtt tccactgagt ctgagtcggt tcatccccgc aggtgcgggg aacacaaaaa      120

aaagttattt atcgtataaa aaaaagtcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1582
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa411_Pseud

<400>  1582
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactttttt       60

ttttcctcct aaggaaggtt ttttttcggt tcatccccgc aggtgcgggg aacacgcact      120

gagacgctga gggtttcaaa gtcacatcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1583
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa412_Pseud

<400>  1583
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagagca       60

cagaagtttt ctgctgtctt tggaatcggt tcatccccgc aggtgcgggg aacacgtgtt      120

cttagaaatt gccatcgaca gtgagcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1584
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa413_Pseud

<400>  1584
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacataata       60

agtattctct gttttcaggt gtgtagcggt tcatccccgc aggtgcgggg aacactggaa      120

ctttccttcc agagatgtgg ctactaacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1585
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa414_Pseud

<400>  1585
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgccgta       60

gctgaaattg gctgcaccat gtcggccggt tcatccccgc aggtgcgggg aacaccactt      120

acagtcaaac accgtgtagt tgaagcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1586
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa415_Pseud

<400>  1586
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgagcat       60

tgcaatttca acgacgtcac aacccgcggt tcatccccgc aggtgcgggg aacactcaag      120

ctgttcgtta aagttacaca ggtccttcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1587
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa416_Pseud

<400>  1587
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactttcca       60

cattccacat tctcattaac atttagcggt tcatccccgc aggtgcgggg aacacgatga      120

aaaatatgca aacatcactg tggattacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1588
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa417_Pseud

<400>  1588
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacctattc       60

catttacctc agagtatgtt ctgctgcggt tcatccccgc aggtgcgggg aacacaaggt      120

ggaactagcc aatatgaata gacttttcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1589
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa418_Pseud

<400>  1589
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacctaggg       60

atcatgaaat aataaactga aaaaaacggt tcatccccgc aggtgcgggg aacacccatt      120

taatcccatg ggcctctgct ccctcaacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1590
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa419_Pseud

<400>  1590
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccagtt       60

gagcaggtac tgggagccaa tattgtcggt tcatccccgc aggtgcgggg aacactccac      120

cgtgcagctc atcacgcagc tcatgcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1591
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa420_Pseud

<400>  1591
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggggac       60

agctctggaa aggggacgct cactcccggt tcatccccgc aggtgcgggg aacacgctgg      120

agggtggcag tgggaccgct ccggcggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1592
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa421_Pseud

<400>  1592
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggggac       60

agctctggaa aggggacgct cactcccggt tcatccccgc aggtgcgggg aacacgctgg      120

agggtggcag tgggaccgct ccggcggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1593
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa422_Pseud

<400>  1593
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaaatgg       60

tattaagctc atcatggaat ttctgccggt tcatccccgc aggtgcgggg aacactattt      120

tagctgctgt ttgaggttta ttttgttcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1594
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa423_Pseud

<400>  1594
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactaacag       60

cacatgcatc tttccctcca gggccacggt tcatccccgc aggtgcgggg aacactttaa      120

cagccacctg ctcccctgta ttgtccccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1595
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa424_Pseud

<400>  1595
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactgcatg       60

aactatgacc ccaatcagag gcctttcggt tcatccccgc aggtgcgggg aacacttaaa      120

gcagcacatg gcaggtctta ctctgctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1596
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa425_Pseud

<400>  1596
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacatgtgt       60

gtctaggcag gacctgtggc caagttcggt tcatccccgc aggtgcgggg aacacgattc      120

actacacgct ctggaatgtt cagttcccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1597
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa426_Pseud

<400>  1597
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaccagg       60

agcccagtgg ggagggtgct ttgttccggt tcatccccgc aggtgcgggg aacacggcct      120

agggtgtgga ggagccttgc catcgggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1598
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa427_Pseud

<400>  1598
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacttgcca       60

tgattttttc agtaaagggc atcttccggt tcatccccgc aggtgcgggg aacacaaatc      120

aaagaaaatt tatctccttt cttcaggcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1599
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa428_Pseud

<400>  1599
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggtttc       60

ctttagaaat aaagagatct cagcagcggt tcatccccgc aggtgcgggg aacacgtctt      120

ccttcacctt ccacaaagca actctttcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1600
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa429_Pseud

<400>  1600
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagatca       60

gcaacaatga gggagcagct gcaccacggt tcatccccgc aggtgcgggg aacactccat      120

ctatttgtct ggtttttgca gccactacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1601
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa430_Pseud

<400>  1601
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccatct       60

gggaactcaa gcaggaagga aggttccggt tcatccccgc aggtgcgggg aacactggca      120

tcaagaggtg ggagggccct ccgaccacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1602
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa431_Pseud

<400>  1602
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacccatct       60

gggaactcaa gcaggaagga aggttccggt tcatccccgc aggtgcgggg aacactggca      120

tcaagaggtg ggagggccct ccgaccacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1603
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa432_Pseud

<400>  1603
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaaaaca       60

aaacataccc tatcaatggc actgcccggt tcatccccgc aggtgcgggg aacacttgtg      120

tcctggctaa atcagaactc gaatggccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1604
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa433_Pseud

<400>  1604
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactacttt       60

tagaaaaata acagtggaga gcacagcggt tcatccccgc aggtgcgggg aacactcctt      120

tcccctgtgt gggataatct ctcccagcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1605
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa434_Pseud

<400>  1605
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactttctc       60

ccaggaagct ttgattttta ccgtttcggt tcatccccgc aggtgcgggg aacactatca      120

ttacaagaga gcaggtgcaa aaggttacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1606
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa435_Pseud

<400>  1606
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgctctg       60

tcgttcgtgg cgctcgtgga cggctacggt tcatccccgc aggtgcgggg aacacacttc      120

ctccagcagc ctcggcggtg ccacctccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1607
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa436_Pseud

<400>  1607
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacggtact       60

ccccctcctt cccaggtcct ccagcccggt tcatccccgc aggtgcgggg aacactgctc      120

tccggccggg ccaacgcgcg gggcctgcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1608
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa437_Pseud

<400>  1608
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgagcat       60

tgcaatttca acgacgtcac aacccgcggt tcatccccgc aggtgcgggg aacacttttc      120

aagctgttcg ttaaagttac acaggtccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1609
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa438_Pseud

<400>  1609
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagtgct       60

cgcttcctgg tctccttggc gcgaaccggt tcatccccgc aggtgcgggg aacacagcat      120

agcagaggat gaggacctca gggttcacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1610
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa439_Pseud

<400>  1610
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactttcaa       60

caatgttctc tagtttcaag ctccagcggt tcatccccgc aggtgcgggg aacacgtagt      120

tcagttatta ttgagtctca ctttctacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1611
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa440_Pseud

<400>  1611
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacacac       60

ccccaacccc aggcagcctc tagagccggt tcatccccgc aggtgcgggg aacacggttt      120

caggcacttc agtaagagac tttcccccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1612
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa345_ilmn_F

<400>  1612
cactctttcc ctacacgacg ctcttccgat cttagcatct ctacgggcca tt               52


<210>  1613
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa346_ilmn_F

<400>  1613
cactctttcc ctacacgacg ctcttccgat ctctcgttgg aagaggaaca gc               52


<210>  1614
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa347_ilmn_F

<400>  1614
cactctttcc ctacacgacg ctcttccgat ctctcgttgg aagaggaaca gc               52


<210>  1615
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa348_ilmn_F

<400>  1615
cactctttcc ctacacgacg ctcttccgat ctagaggagc tgaagaccca ca               52


<210>  1616
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa349_ilmn_F

<400>  1616
cactctttcc ctacacgacg ctcttccgat ctcacagggt gatgattgat gg               52


<210>  1617
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa350_ilmn_F

<400>  1617
cactctttcc ctacacgacg ctcttccgat ctgagaagga cttgataatc tgtgga           56


<210>  1618
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa351_ilmn_F

<400>  1618
cactctttcc ctacacgacg ctcttccgat ctccgacaga tagaagatca cttcc            55


<210>  1619
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa352_ilmn_F

<400>  1619
cactctttcc ctacacgacg ctcttccgat ctctgcatgg ccgacaagat                  50


<210>  1620
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa353_ilmn_F

<400>  1620
cactctttcc ctacacgacg ctcttccgat ctttggatgg aatactattt ggaaca           56


<210>  1621
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa354_ilmn_F

<400>  1621
cactctttcc ctacacgacg ctcttccgat ctaccctgtt cagtgctctg ct               52


<210>  1622
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa355_ilmn_F

<400>  1622
cactctttcc ctacacgacg ctcttccgat cttgcccatg actattctag caac             54


<210>  1623
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa356_ilmn_F

<400>  1623
cactctttcc ctacacgacg ctcttccgat ctaacattgt tgaaaggctg gc               52


<210>  1624
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa357_ilmn_F

<400>  1624
cactctttcc ctacacgacg ctcttccgat cttcaatcaa aggtggtctg ga               52


<210>  1625
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa358_ilmn_F

<400>  1625
cactctttcc ctacacgacg ctcttccgat ctaccctgtt cagtgctctg ct               52


<210>  1626
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa359_ilmn_F

<400>  1626
cactctttcc ctacacgacg ctcttccgat ctgagagaga gagaggcagg ca               52


<210>  1627
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa360_ilmn_F

<400>  1627
cactctttcc ctacacgacg ctcttccgat cttcactgca ccatagagac gc               52


<210>  1628
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa361_ilmn_F

<400>  1628
cactctttcc ctacacgacg ctcttccgat ctttggagga gagatgaggg aa               52


<210>  1629
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa362_ilmn_F

<400>  1629
cactctttcc ctacacgacg ctcttccgat cttcctgtgt gagtgctgca a                51


<210>  1630
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa363_ilmn_F

<400>  1630
cactctttcc ctacacgacg ctcttccgat ctggaatcct gcacccacta aa               52


<210>  1631
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa364_ilmn_F

<400>  1631
cactctttcc ctacacgacg ctcttccgat ctgagagatg caccttattt ctctagtgt        59


<210>  1632
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa365_ilmn_F

<400>  1632
cactctttcc ctacacgacg ctcttccgat ctaaatttcc aatagtttgg agactca          57


<210>  1633
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa366_ilmn_F

<400>  1633
cactctttcc ctacacgacg ctcttccgat ctccagcacc acaggacata aa               52


<210>  1634
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa367_ilmn_F

<400>  1634
cactctttcc ctacacgacg ctcttccgat ctgactcacc aggccactct tc               52


<210>  1635
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa368_ilmn_F

<400>  1635
cactctttcc ctacacgacg ctcttccgat ctttgttcct ccacctcatt cc               52


<210>  1636
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa369_ilmn_F

<400>  1636
cactctttcc ctacacgacg ctcttccgat ctttcatcag aataccacta ttttcatttt       60


<210>  1637
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa370_ilmn_F

<400>  1637
cactctttcc ctacacgacg ctcttccgat ctttttcatt ttagttgcta ctctttgatt       60


<210>  1638
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa371_ilmn_F

<400>  1638
cactctttcc ctacacgacg ctcttccgat cttgttgcct tggtgagtct tct              53


<210>  1639
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa372_ilmn_F

<400>  1639
cactctttcc ctacacgacg ctcttccgat ctttatggag cttccattta gtggt            55


<210>  1640
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa373_ilmn_F

<400>  1640
cactctttcc ctacacgacg ctcttccgat ctaacagaag tgacagcttt gagaac           56


<210>  1641
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa374_ilmn_F

<400>  1641
cactctttcc ctacacgacg ctcttccgat ctgccttgtc ctcagccagt ta               52


<210>  1642
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa375_ilmn_F

<400>  1642
cactctttcc ctacacgacg ctcttccgat ctatttaatc ccatgggcct ct               52


<210>  1643
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa376_ilmn_F

<400>  1643
cactctttcc ctacacgacg ctcttccgat ctccacagga gcacatcaag ac               52


<210>  1644
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa377_ilmn_F

<400>  1644
cactctttcc ctacacgacg ctcttccgat ctgttcctgt attgcggcag ag               52


<210>  1645
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa378_ilmn_F

<400>  1645
cactctttcc ctacacgacg ctcttccgat ctaagcaggt accaagacac gc               52


<210>  1646
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa379_ilmn_F

<400>  1646
cactctttcc ctacacgacg ctcttccgat ctcaactcct tgcttgggaa gt               52


<210>  1647
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa380_ilmn_F

<400>  1647
cactctttcc ctacacgacg ctcttccgat ctaagggaat gcctccttcc ta               52


<210>  1648
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa381_ilmn_F

<400>  1648
cactctttcc ctacacgacg ctcttccgat ctctcctctt tgaaacgatt agtaatga         58


<210>  1649
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa382_ilmn_F

<400>  1649
cactctttcc ctacacgacg ctcttccgat cttgatttca gaaagtctca actacca          57


<210>  1650
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa383_ilmn_F

<400>  1650
cactctttcc ctacacgacg ctcttccgat ctaccctgtt cagtgctctg ct               52


<210>  1651
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa384_ilmn_F

<400>  1651
cactctttcc ctacacgacg ctcttccgat ctaacattgt tgaaaggctg gc               52


<210>  1652
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa385_ilmn_F

<400>  1652
cactctttcc ctacacgacg ctcttccgat ctggactggc aggtcaagga ta               52


<210>  1653
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa386_ilmn_F

<400>  1653
cactctttcc ctacacgacg ctcttccgat ctggcaacta ttccagcttc ca               52


<210>  1654
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa387_ilmn_F

<400>  1654
cactctttcc ctacacgacg ctcttccgat ctggtcctgc ctagacacac atc              53


<210>  1655
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa388_ilmn_F

<400>  1655
cactctttcc ctacacgacg ctcttccgat ctcacttcca attcagcaag ca               52


<210>  1656
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa389_ilmn_F

<400>  1656
cactctttcc ctacacgacg ctcttccgat ctgttgactt tgagcaggag gc               52


<210>  1657
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa390_ilmn_F

<400>  1657
cactctttcc ctacacgacg ctcttccgat ctcacctggg tagtccttga tga              53


<210>  1658
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa391_ilmn_F

<400>  1658
cactctttcc ctacacgacg ctcttccgat ctgagagatg caccttattt ctctagtgt        59


<210>  1659
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa392_ilmn_F

<400>  1659
cactctttcc ctacacgacg ctcttccgat ctgtttccaa gacatgatgg gc               52


<210>  1660
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa393_ilmn_F

<400>  1660
cactctttcc ctacacgacg ctcttccgat cttttcatca tagggctttg cac              53


<210>  1661
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa394_ilmn_F

<400>  1661
cactctttcc ctacacgacg ctcttccgat ctaagccatg gagatcagag ga               52


<210>  1662
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa395_ilmn_F

<400>  1662
cactctttcc ctacacgacg ctcttccgat ctttcccttg actttggcat tt               52


<210>  1663
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa396_ilmn_F

<400>  1663
cactctttcc ctacacgacg ctcttccgat ctttcccttg actttggcat tt               52


<210>  1664
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa397_ilmn_F

<400>  1664
cactctttcc ctacacgacg ctcttccgat cttcttaggg acacggctga ct               52


<210>  1665
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa398_ilmn_F

<400>  1665
cactctttcc ctacacgacg ctcttccgat ctagatgtct gtggagagcc gt               52


<210>  1666
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa399_ilmn_F

<400>  1666
cactctttcc ctacacgacg ctcttccgat ctaaatgttt tggccttttg ga               52


<210>  1667
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa400_ilmn_F

<400>  1667
cactctttcc ctacacgacg ctcttccgat ctcatgcgtg atgacgtaga gg               52


<210>  1668
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa401_ilmn_F

<400>  1668
cactctttcc ctacacgacg ctcttccgat ctggtcctgc ctagacacac atc              53


<210>  1669
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa402_ilmn_F

<400>  1669
cactctttcc ctacacgacg ctcttccgat cttttaccac acaaagtggg ca               52


<210>  1670
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa403_ilmn_F

<400>  1670
cactctttcc ctacacgacg ctcttccgat ctaatagtcc agctgcgatg gt               52


<210>  1671
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa404_ilmn_F

<400>  1671
cactctttcc ctacacgacg ctcttccgat cttgcccatg actattctag caac             54


<210>  1672
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa405_ilmn_F

<400>  1672
cactctttcc ctacacgacg ctcttccgat ctatttaatc ccatgggcct ct               52


<210>  1673
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa406_ilmn_F

<400>  1673
cactctttcc ctacacgacg ctcttccgat ctctcgttgg aagaggaaca gc               52


<210>  1674
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa407_ilmn_F

<400>  1674
cactctttcc ctacacgacg ctcttccgat ctctcgttgg aagaggaaca gc               52


<210>  1675
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa408_ilmn_F

<400>  1675
cactctttcc ctacacgacg ctcttccgat ctcccatcaa gccaactctc at               52


<210>  1676
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa409_ilmn_F

<400>  1676
cactctttcc ctacacgacg ctcttccgat ctcaaccaat gaaaccaagg ct               52


<210>  1677
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa410_ilmn_F

<400>  1677
cactctttcc ctacacgacg ctcttccgat ctcaagacaa aaatccaaca agca             54


<210>  1678
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa411_ilmn_F

<400>  1678
cactctttcc ctacacgacg ctcttccgat ctggctaagg gcacaagaga atta             54


<210>  1679
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa412_ilmn_F

<400>  1679
cactctttcc ctacacgacg ctcttccgat ctagccctgt actaccagcg tg               52


<210>  1680
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa413_ilmn_F

<400>  1680
cactctttcc ctacacgacg ctcttccgat ctaaaccttt ggttggatgc tg               52


<210>  1681
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa414_ilmn_F

<400>  1681
cactctttcc ctacacgacg ctcttccgat ctagttgccc atggtcacaa at               52


<210>  1682
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa415_ilmn_F

<400>  1682
cactctttcc ctacacgacg ctcttccgat ctctgctgcc agaaatggag tc               52


<210>  1683
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa416_ilmn_F

<400>  1683
cactctttcc ctacacgacg ctcttccgat ctgggatatt tggttagttg atttgatatt       60


<210>  1684
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa417_ilmn_F

<400>  1684
cactctttcc ctacacgacg ctcttccgat ctttttcatt ttagttgcta ctctttgatt       60


<210>  1685
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa418_ilmn_F

<400>  1685
cactctttcc ctacacgacg ctcttccgat ctttcttgtc aggccctaca cc               52


<210>  1686
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa419_ilmn_F

<400>  1686
cactctttcc ctacacgacg ctcttccgat ctctccagga agcctacgtg at               52


<210>  1687
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa420_ilmn_F

<400>  1687
cactctttcc ctacacgacg ctcttccgat ctcccagagc ctcagagaag g                51


<210>  1688
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa421_ilmn_F

<400>  1688
cactctttcc ctacacgacg ctcttccgat ctcccagagc ctcagagaag g                51


<210>  1689
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa422_ilmn_F

<400>  1689
cactctttcc ctacacgacg ctcttccgat ctttacccag gacagagtgc ct               52


<210>  1690
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa423_ilmn_F

<400>  1690
cactctttcc ctacacgacg ctcttccgat ctacctccac tctcaggctt ca               52


<210>  1691
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa424_ilmn_F

<400>  1691
cactctttcc ctacacgacg ctcttccgat ctaaacagag tgaaaggcag tcg              53


<210>  1692
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa425_ilmn_F

<400>  1692
cactctttcc ctacacgacg ctcttccgat ctccacggga atggagagat ta               52


<210>  1693
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa426_ilmn_F

<400>  1693
cactctttcc ctacacgacg ctcttccgat ctttcccttg actttggcat tt               52


<210>  1694
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa427_ilmn_F

<400>  1694
cactctttcc ctacacgacg ctcttccgat ctccagcacc acaggacata aa               52


<210>  1695
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa428_ilmn_F

<400>  1695
cactctttcc ctacacgacg ctcttccgat cttcatcctg agcactctgt gg               52


<210>  1696
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa429_ilmn_F

<400>  1696
cactctttcc ctacacgacg ctcttccgat ctgcctcagg ctgtctgaac tc               52


<210>  1697
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa430_ilmn_F

<400>  1697
cactctttcc ctacacgacg ctcttccgat ctcagaagcc ctgatgtgtc ct               52


<210>  1698
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa431_ilmn_F

<400>  1698
cactctttcc ctacacgacg ctcttccgat ctcagaagcc ctgatgtgtc ct               52


<210>  1699
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa432_ilmn_F

<400>  1699
cactctttcc ctacacgacg ctcttccgat ctcccatcaa gccaactctc at               52


<210>  1700
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa433_ilmn_F

<400>  1700
cactctttcc ctacacgacg ctcttccgat cttttcatca tagggctttg cac              53


<210>  1701
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa434_ilmn_F

<400>  1701
cactctttcc ctacacgacg ctcttccgat ctagaacaag ggaggagctg gt               52


<210>  1702
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa435_ilmn_F

<400>  1702
cactctttcc ctacacgacg ctcttccgat ctacaggtcc ttacgtgatg gg               52


<210>  1703
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa436_ilmn_F

<400>  1703
cactctttcc ctacacgacg ctcttccgat ctggaatcct gcacccacta aa               52


<210>  1704
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa437_ilmn_F

<400>  1704
cactctttcc ctacacgacg ctcttccgat ctctgctgcc agaaatggag tc               52


<210>  1705
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa438_ilmn_F

<400>  1705
cactctttcc ctacacgacg ctcttccgat ctccttgact tgatgcacct ga               52


<210>  1706
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa439_ilmn_F

<400>  1706
cactctttcc ctacacgacg ctcttccgat ctaggagagt agaattgggc tgg              53


<210>  1707
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa440_ilmn_F

<400>  1707
cactctttcc ctacacgacg ctcttccgat ctaacattgt tgaaaggctg gc               52


<210>  1708
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa345_ilmn_R

<400>  1708
ggagttcaga cgtgtgctct tccgatctta ccagagagct caggaggg                    48


<210>  1709
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa346_ilmn_R

<400>  1709
ggagttcaga cgtgtgctct tccgatctac agtctctgaa tgggtcgc                    48


<210>  1710
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa347_ilmn_R

<400>  1710
ggagttcaga cgtgtgctct tccgatctac agtctctgaa tgggtcgc                    48


<210>  1711
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa348_ilmn_R

<400>  1711
ggagttcaga cgtgtgctct tccgatctta actggctgag gacaaggc                    48


<210>  1712
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa349_ilmn_R

<400>  1712
ggagttcaga cgtgtgctct tccgatctac tcattcccag aacctgga                    48


<210>  1713
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa350_ilmn_R

<400>  1713
ggagttcaga cgtgtgctct tccgatctaa aagtcattgc atttccaaaa                  50


<210>  1714
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa351_ilmn_R

<400>  1714
ggagttcaga cgtgtgctct tccgatctcc aacaccaaat gtttctgc                    48


<210>  1715
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa352_ilmn_R

<400>  1715
ggagttcaga cgtgtgctct tccgatcttg ttcacctgtt tcatctgagg                  50


<210>  1716
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa353_ilmn_R

<400>  1716
ggagttcaga cgtgtgctct tccgatctca gcaaccacac ccatagtg                    48


<210>  1717
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa354_ilmn_R

<400>  1717
ggagttcaga cgtgtgctct tccgatctgg ttcagaagcc ctggaaat                    48


<210>  1718
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa355_ilmn_R

<400>  1718
ggagttcaga cgtgtgctct tccgatctag ctggatccac atggtctt                    48


<210>  1719
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa356_ilmn_R

<400>  1719
ggagttcaga cgtgtgctct tccgatctaa ggaatggtcc tctgggag                    48


<210>  1720
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa357_ilmn_R

<400>  1720
ggagttcaga cgtgtgctct tccgatctcc ggaggtccca aacagt                      46


<210>  1721
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa358_ilmn_R

<400>  1721
ggagttcaga cgtgtgctct tccgatctgg ttcagaagcc ctggaaat                    48


<210>  1722
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa359_ilmn_R

<400>  1722
ggagttcaga cgtgtgctct tccgatcttc agactcccag aattgggt                    48


<210>  1723
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa360_ilmn_R

<400>  1723
ggagttcaga cgtgtgctct tccgatctgt cagcatgatg tcagaggc                    48


<210>  1724
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa361_ilmn_R

<400>  1724
ggagttcaga cgtgtgctct tccgatcttt gcagcactca cacagga                     47


<210>  1725
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa362_ilmn_R

<400>  1725
ggagttcaga cgtgtgctct tccgatctat ctcttacgcc caaccctt                    48


<210>  1726
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa363_ilmn_R

<400>  1726
ggagttcaga cgtgtgctct tccgatcttt gaatggcaaa gggatagg                    48


<210>  1727
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa364_ilmn_R

<400>  1727
ggagttcaga cgtgtgctct tccgatctgt aaaggttgta ataccttcca ctaggt           56


<210>  1728
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa365_ilmn_R

<400>  1728
ggagttcaga cgtgtgctct tccgatctaa catttggtag ttgagacttt ctga             54


<210>  1729
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa366_ilmn_R

<400>  1729
ggagttcaga cgtgtgctct tccgatctga tagccttcat cttgccca                    48


<210>  1730
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa367_ilmn_R

<400>  1730
ggagttcaga cgtgtgctct tccgatctta gcccacatgt ccacattc                    48


<210>  1731
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa368_ilmn_R

<400>  1731
ggagttcaga cgtgtgctct tccgatctaa ctgctaatgg cccgttct                    48


<210>  1732
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa369_ilmn_R

<400>  1732
ggagttcaga cgtgtgctct tccgatctat ggtacttgat tgctattcca tt               52


<210>  1733
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa370_ilmn_R

<400>  1733
ggagttcaga cgtgtgctct tccgatcttt cactgaatat ggtacttgat tgc              53


<210>  1734
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa371_ilmn_R

<400>  1734
ggagttcaga cgtgtgctct tccgatctga tgcaatgcca acttgaga                    48


<210>  1735
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa372_ilmn_R

<400>  1735
ggagttcaga cgtgtgctct tccgatctgc tgatcttaaa atattactga cctgg            55


<210>  1736
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa373_ilmn_R

<400>  1736
ggagttcaga cgtgtgctct tccgatctga gaggactggg aaatgcac                    48


<210>  1737
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa374_ilmn_R

<400>  1737
ggagttcaga cgtgtgctct tccgatcttg gatgcaaggc atacacac                    48


<210>  1738
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa375_ilmn_R

<400>  1738
ggagttcaga cgtgtgctct tccgatctgc aacatccttc aattgcg                     47


<210>  1739
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa376_ilmn_R

<400>  1739
ggagttcaga cgtgtgctct tccgatctca tcctcccagc atgctcta                    48


<210>  1740
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa377_ilmn_R

<400>  1740
ggagttcaga cgtgtgctct tccgatctac ctcagaggct gttcttgg                    48


<210>  1741
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa378_ilmn_R

<400>  1741
ggagttcaga cgtgtgctct tccgatctct tctttcgaat cccaaatacc t                51


<210>  1742
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa379_ilmn_R

<400>  1742
ggagttcaga cgtgtgctct tccgatctag ggcagtacag caggagaa                    48


<210>  1743
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa380_ilmn_R

<400>  1743
ggagttcaga cgtgtgctct tccgatctac ctacctctca gccactgc                    48


<210>  1744
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa381_ilmn_R

<400>  1744
ggagttcaga cgtgtgctct tccgatctct tcatcaaata tgtcaccaga agtt             54


<210>  1745
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa382_ilmn_R

<400>  1745
ggagttcaga cgtgtgctct tccgatcttg atagaagact caccaaggca                  50


<210>  1746
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa383_ilmn_R

<400>  1746
ggagttcaga cgtgtgctct tccgatctgg ttcagaagcc ctggaaat                    48


<210>  1747
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa384_ilmn_R

<400>  1747
ggagttcaga cgtgtgctct tccgatctaa ggaatggtcc tctgggag                    48


<210>  1748
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa385_ilmn_R

<400>  1748
ggagttcaga cgtgtgctct tccgatcttc actcctactg aggctggg                    48


<210>  1749
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa386_ilmn_R

<400>  1749
ggagttcaga cgtgtgctct tccgatctgt tcatgcagcc tcttgtcc                    48


<210>  1750
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa387_ilmn_R

<400>  1750
ggagttcaga cgtgtgctct tccgatcttt ccactgagtc tgagtcttca a                51


<210>  1751
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa388_ilmn_R

<400>  1751
ggagttcaga cgtgtgctct tccgatctga aaccctcagc gtctcagt                    48


<210>  1752
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa389_ilmn_R

<400>  1752
ggagttcaga cgtgtgctct tccgatctca cactgatgaa gcgtgtcc                    48


<210>  1753
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa390_ilmn_R

<400>  1753
ggagttcaga cgtgtgctct tccgatcttt gggaaagctg gctacact                    48


<210>  1754
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa391_ilmn_R

<400>  1754
ggagttcaga cgtgtgctct tccgatctgt aaaggttgta ataccttcca ctaggt           56


<210>  1755
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa392_ilmn_R

<400>  1755
ggagttcaga cgtgtgctct tccgatcttg ccaatttaag agaacggg                    48


<210>  1756
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa393_ilmn_R

<400>  1756
ggagttcaga cgtgtgctct tccgatctag cagaagagga cagtaaacaa tg               52


<210>  1757
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa394_ilmn_R

<400>  1757
ggagttcaga cgtgtgctct tccgatctag aacaggcctc ccaagttt                    48


<210>  1758
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa395_ilmn_R

<400>  1758
ggagttcaga cgtgtgctct tccgatctgt gaggacttgg agctctgc                    48


<210>  1759
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa396_ilmn_R

<400>  1759
ggagttcaga cgtgtgctct tccgatctca ggcgtatctg tgtgagga                    48


<210>  1760
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa397_ilmn_R

<400>  1760
ggagttcaga cgtgtgctct tccgatctag caggcttctc acttccag                    48


<210>  1761
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa398_ilmn_R

<400>  1761
ggagttcaga cgtgtgctct tccgatctat tctgggagac cagcacac                    48


<210>  1762
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa399_ilmn_R

<400>  1762
ggagttcaga cgtgtgctct tccgatcttg cttgccagct ctaatcaa                    48


<210>  1763
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa400_ilmn_R

<400>  1763
ggagttcaga cgtgtgctct tccgatcttc gcacacttaa ggctaacg                    48


<210>  1764
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa401_ilmn_R

<400>  1764
ggagttcaga cgtgtgctct tccgatcttt ccactgagtc tgagtcttca a                51


<210>  1765
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa402_ilmn_R

<400>  1765
ggagttcaga cgtgtgctct tccgatctga agtcggcctc tctctcct                    48


<210>  1766
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa403_ilmn_R

<400>  1766
ggagttcaga cgtgtgctct tccgatctgc gagagtatcg tctgagcc                    48


<210>  1767
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa404_ilmn_R

<400>  1767
ggagttcaga cgtgtgctct tccgatctga tccacatggt cttgaggg                    48


<210>  1768
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa405_ilmn_R

<400>  1768
ggagttcaga cgtgtgctct tccgatctgc aacatccttc aattgcg                     47


<210>  1769
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa406_ilmn_R

<400>  1769
ggagttcaga cgtgtgctct tccgatctac agtctctgaa tgggtcgc                    48


<210>  1770
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa407_ilmn_R

<400>  1770
ggagttcaga cgtgtgctct tccgatctac agtctctgaa tgggtcgc                    48


<210>  1771
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa408_ilmn_R

<400>  1771
ggagttcaga cgtgtgctct tccgatctac caaacacagc agggactc                    48


<210>  1772
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa409_ilmn_R

<400>  1772
ggagttcaga cgtgtgctct tccgatctac ctctgttctg agccgcta                    48


<210>  1773
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa410_ilmn_R

<400>  1773
ggagttcaga cgtgtgctct tccgatctag agggtccagc ctcaagat                    48


<210>  1774
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa411_ilmn_R

<400>  1774
ggagttcaga cgtgtgctct tccgatctgg agtggcctct ttgtgtgt                    48


<210>  1775
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa412_ilmn_R

<400>  1775
ggagttcaga cgtgtgctct tccgatctcc accctgacac ataaaccc                    48


<210>  1776
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa413_ilmn_R

<400>  1776
ggagttcaga cgtgtgctct tccgatctaa tgattgttgg agtgctttca                  50


<210>  1777
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa414_ilmn_R

<400>  1777
ggagttcaga cgtgtgctct tccgatctgc caatgtttgg agtctggt                    48


<210>  1778
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa415_ilmn_R

<400>  1778
ggagttcaga cgtgtgctct tccgatcttt acccttgtgt gtgtctccc                   49


<210>  1779
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa416_ilmn_R

<400>  1779
ggagttcaga cgtgtgctct tccgatctat gcacctcatt gtttgtgc                    48


<210>  1780
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa417_ilmn_R

<400>  1780
ggagttcaga cgtgtgctct tccgatcttt cactgaatat ggtacttgat tgc              53


<210>  1781
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa418_ilmn_R

<400>  1781
ggagttcaga cgtgtgctct tccgatctca tggtagagca gcatccag                    48


<210>  1782
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa419_ilmn_R

<400>  1782
ggagttcaga cgtgtgctct tccgatctcc gtatctccct tccctgat                    48


<210>  1783
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa420_ilmn_R

<400>  1783
ggagttcaga cgtgtgctct tccgatctgt ttcgcgtttt ctggatgt                    48


<210>  1784
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa421_ilmn_R

<400>  1784
ggagttcaga cgtgtgctct tccgatctgt ttcgcgtttt ctggatgt                    48


<210>  1785
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa422_ilmn_R

<400>  1785
ggagttcaga cgtgtgctct tccgatctct catttggcag cctcagac                    48


<210>  1786
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa423_ilmn_R

<400>  1786
ggagttcaga cgtgtgctct tccgatctga cttctgtgtg ttccgtgg                    48


<210>  1787
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa424_ilmn_R

<400>  1787
ggagttcaga cgtgtgctct tccgatcttg taaggagctg gctgacct                    48


<210>  1788
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa425_ilmn_R

<400>  1788
ggagttcaga cgtgtgctct tccgatcttg cttgttggat ttttgtcttg                  50


<210>  1789
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa426_ilmn_R

<400>  1789
ggagttcaga cgtgtgctct tccgatctgt gaggacttgg agctctgc                    48


<210>  1790
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa427_ilmn_R

<400>  1790
ggagttcaga cgtgtgctct tccgatctga tagccttcat cttgccca                    48


<210>  1791
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa428_ilmn_R

<400>  1791
ggagttcaga cgtgtgctct tccgatctag ccttaccctg gcatcttt                    48


<210>  1792
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa429_ilmn_R

<400>  1792
ggagttcaga cgtgtgctct tccgatctag ctggaggtag tggagcaa                    48


<210>  1793
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa430_ilmn_R

<400>  1793
ggagttcaga cgtgtgctct tccgatctgg cctcagaatc cacaaaga                    48


<210>  1794
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa431_ilmn_R

<400>  1794
ggagttcaga cgtgtgctct tccgatctgg cctcagaatc cacaaaga                    48


<210>  1795
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa432_ilmn_R

<400>  1795
ggagttcaga cgtgtgctct tccgatctac caaacacagc agggactc                    48


<210>  1796
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa433_ilmn_R

<400>  1796
ggagttcaga cgtgtgctct tccgatctag cagaagagga cagtaaacaa tg               52


<210>  1797
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa434_ilmn_R

<400>  1797
ggagttcaga cgtgtgctct tccgatctct ctgccgcaat acaggaac                    48


<210>  1798
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa435_ilmn_R

<400>  1798
ggagttcaga cgtgtgctct tccgatctgt ttcactgggc tctgacg                     47


<210>  1799
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa436_ilmn_R

<400>  1799
ggagttcaga cgtgtgctct tccgatcttt gaatggcaaa gggatagg                    48


<210>  1800
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa437_ilmn_R

<400>  1800
ggagttcaga cgtgtgctct tccgatcttt acccttgtgt gtgtctccc                   49


<210>  1801
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa438_ilmn_R

<400>  1801
ggagttcaga cgtgtgctct tccgatctcc cagcctgctt ctgattta                    48


<210>  1802
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa439_ilmn_R

<400>  1802
ggagttcaga cgtgtgctct tccgatctga agtgcctgaa acccaaag                    48


<210>  1803
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa440_ilmn_R

<400>  1803
ggagttcaga cgtgtgctct tccgatctaa ggaatggtcc tctgggag                    48


<210>  1804
<211>  8729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas3-10aa-FokI

<400>  1804
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggg gggcagcgga agtagtggcg ggagtgggca     3660

gctggtgaag tccgagctgg aggagaagaa gagcgagctg cgccacaagc tgaagtacgt     3720

gccccacgag tatatcgagc tgatcgagat cgccaggaat cctacccagg atcgcatcct     3780

ggagatgaaa gtgatggagt tctttatgaa ggtgtacggc tataggggag agcacctggg     3840

aggcagccgc aagcctgacg gcgccatcta cacagtgggc tccccaatcg actatggcgt     3900

gatcgtggat accaaggcct acagcggcgg ctataacctg ccaatcggac aggcagacga     3960

gatgcagcgg tacgtggagg agaaccagac aagaaataag cacatcaacc caaatgagtg     4020

gtggaaggtg tatccctcct ctgtgaccga gttcaagttt ctgttcgtgt ccggccactt     4080

taagggcaac tacaaggccc agctgacacg gctgaatcac atcaccaact gtaatggcgc     4140

cgtgctgtct gtggaggagc tgctgatcgg cggcgagatg atcaaggccg gcaccctgac     4200

actggaggag gtgagaagga agtttaacaa tggcgagatc aatttctaac attggaagtg     4260

gataatctag agggccctat tctatagtgt cacctaaatg ctagagctcg ctgatcagcc     4320

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     4380

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4440

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4500

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     4560

gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc     4620

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4680

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4740

ctaaatcggg gcatcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4800

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4860

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     4920

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttggggat ttcggcctat     4980

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt     5040

gtcagttagg gtgtggaaag tccccaggct ccccaggcag gcagaagtat gcaaagcatg     5100

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     5160

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     5220

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     5280

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     5340

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     5400

tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     5460

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     5520

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     5580

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     5640

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     5700

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     5760

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     5820

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     5880

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     5940

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     6000

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     6060

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     6120

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     6180

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg     6240

ggttcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg     6300

ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc     6360

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     6420

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     6480

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt     6540

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     6600

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     6660

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     6720

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     6780

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     6840

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     6900

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     6960

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     7020

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     7080

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     7140

tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc agttcggtgt     7200

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     7260

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     7320

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     7380

tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc     7440

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     7500

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     7560

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     7620

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     7680

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     7740

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     7800

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     7860

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     7920

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     7980

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     8040

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     8100

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     8160

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     8220

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     8280

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     8340

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     8400

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     8460

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     8520

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     8580

gttgaatact catactcttc ctttttcatt attattgaag catttatcag ggttattgtc     8640

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     8700

catttccccg aaaagtgcca cctgacgtc                                       8729


<210>  1805
<211>  8750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas3-17aa-FokI

<400>  1805
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggc tgacccaact aacagagcta agggcctgga     3660

ggccgtatct gtggcatcac agctggtgaa gtccgagctg gaggagaaga agagcgagct     3720

gcgccacaag ctgaagtacg tgccccacga gtatatcgag ctgatcgaga tcgccaggaa     3780

tcctacccag gatcgcatcc tggagatgaa agtgatggag ttctttatga aggtgtacgg     3840

ctatagggga gagcacctgg gaggcagccg caagcctgac ggcgccatct acacagtggg     3900

ctccccaatc gactatggcg tgatcgtgga taccaaggcc tacagcggcg gctataacct     3960

gccaatcgga caggcagacg agatgcagcg gtacgtggag gagaaccaga caagaaataa     4020

gcacatcaac ccaaatgagt ggtggaaggt gtatccctcc tctgtgaccg agttcaagtt     4080

tctgttcgtg tccggccact ttaagggcaa ctacaaggcc cagctgacac ggctgaatca     4140

catcaccaac tgtaatggcg ccgtgctgtc tgtggaggag ctgctgatcg gcggcgagat     4200

gatcaaggcc ggcaccctga cactggagga ggtgagaagg aagtttaaca atggcgagat     4260

caatttctaa cattggaagt ggataatcta gagggcccta ttctatagtg tcacctaaat     4320

gctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc     4380

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4440

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4500

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4560

ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg     4620

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4680

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4740

gccggctttc cccgtcaagc tctaaatcgg ggcatccctt tagggttccg atttagtgct     4800

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     4860

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     4920

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     4980

attttgggga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5040

aattaattct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccaggca     5100

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca     5160

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc     5220

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     5280

catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta     5340

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga     5400

gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt tcgcatgatt     5460

gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat     5520

gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag     5580

gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac     5640

gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac     5700

gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc     5760

ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg     5820

ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag     5880

cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat     5940

caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag     6000

gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc     6060

ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg     6120

ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg     6180

ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag     6240

ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat     6300

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc     6360

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc     6420

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     6480

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     6540

cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc     6600

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca     6660

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct     6720

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac     6780

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     6840

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     6900

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     6960

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     7020

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     7080

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     7140

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct     7200

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     7260

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     7320

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     7380

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     7440

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     7500

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     7560

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     7620

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     7680

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     7740

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     7800

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     7860

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     7920

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     7980

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     8040

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     8100

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     8160

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     8220

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     8280

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     8340

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     8400

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     8460

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     8520

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     8580

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcat tattattgaa     8640

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     8700

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc                8750


<210>  1806
<211>  8789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas3-30aa-FokI

<400>  1806
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaagag cggctccgaa acgccgggta catccgagtc     3660

cgcgactcct gagtcaggag gcagcggctc ctctggtgga agcggctcaa gtggagggca     3720

gctggtgaag tccgagctgg aggagaagaa gagcgagctg cgccacaagc tgaagtacgt     3780

gccccacgag tatatcgagc tgatcgagat cgccaggaat cctacccagg atcgcatcct     3840

ggagatgaaa gtgatggagt tctttatgaa ggtgtacggc tataggggag agcacctggg     3900

aggcagccgc aagcctgacg gcgccatcta cacagtgggc tccccaatcg actatggcgt     3960

gatcgtggat accaaggcct acagcggcgg ctataacctg ccaatcggac aggcagacga     4020

gatgcagcgg tacgtggagg agaaccagac aagaaataag cacatcaacc caaatgagtg     4080

gtggaaggtg tatccctcct ctgtgaccga gttcaagttt ctgttcgtgt ccggccactt     4140

taagggcaac tacaaggccc agctgacacg gctgaatcac atcaccaact gtaatggcgc     4200

cgtgctgtct gtggaggagc tgctgatcgg cggcgagatg atcaaggccg gcaccctgac     4260

actggaggag gtgagaagga agtttaacaa tggcgagatc aatttctaac attggaagtg     4320

gataatctag agggccctat tctatagtgt cacctaaatg ctagagctcg ctgatcagcc     4380

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     4440

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4500

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4560

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     4620

gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc     4680

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4740

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4800

ctaaatcggg gcatcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4860

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4920

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     4980

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttggggat ttcggcctat     5040

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt     5100

gtcagttagg gtgtggaaag tccccaggct ccccaggcag gcagaagtat gcaaagcatg     5160

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     5220

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     5280

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     5340

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     5400

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     5460

tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     5520

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     5580

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     5640

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     5700

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     5760

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     5820

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     5880

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     5940

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     6000

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     6060

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     6120

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     6180

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     6240

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg     6300

ggttcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg     6360

ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc     6420

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     6480

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     6540

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt     6600

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     6660

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     6720

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     6780

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     6840

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     6900

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     6960

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     7020

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     7080

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     7140

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     7200

tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc agttcggtgt     7260

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     7320

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     7380

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     7440

tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc     7500

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     7560

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     7620

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     7680

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     7740

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     7800

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     7860

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     7920

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     7980

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     8040

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     8100

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     8160

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     8220

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     8280

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     8340

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     8400

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     8460

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     8520

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     8580

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     8640

gttgaatact catactcttc ctttttcatt attattgaag catttatcag ggttattgtc     8700

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     8760

catttccccg aaaagtgcca cctgacgtc                                       8789


<210>  1807
<211>  8819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-Cas3-40aa-FokI

<400>  1807
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaagag cggctccgaa acgccgggta catccgagtc     3660

cgcgactcct gagtcaggag gcagcggctc ctctggtgga agcggctcaa gtggagggag     3720

cggctcaagt ggtggaagcg gctcaagtca gctggtgaag tccgagctgg aggagaagaa     3780

gagcgagctg cgccacaagc tgaagtacgt gccccacgag tatatcgagc tgatcgagat     3840

cgccaggaat cctacccagg atcgcatcct ggagatgaaa gtgatggagt tctttatgaa     3900

ggtgtacggc tataggggag agcacctggg aggcagccgc aagcctgacg gcgccatcta     3960

cacagtgggc tccccaatcg actatggcgt gatcgtggat accaaggcct acagcggcgg     4020

ctataacctg ccaatcggac aggcagacga gatgcagcgg tacgtggagg agaaccagac     4080

aagaaataag cacatcaacc caaatgagtg gtggaaggtg tatccctcct ctgtgaccga     4140

gttcaagttt ctgttcgtgt ccggccactt taagggcaac tacaaggccc agctgacacg     4200

gctgaatcac atcaccaact gtaatggcgc cgtgctgtct gtggaggagc tgctgatcgg     4260

cggcgagatg atcaaggccg gcaccctgac actggaggag gtgagaagga agtttaacaa     4320

tggcgagatc aatttctaac attggaagtg gataatctag agggccctat tctatagtgt     4380

cacctaaatg ctagagctcg ctgatcagcc tcgactgtgc cttctagttg ccagccatct     4440

gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt     4500

tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg     4560

ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg     4620

gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc tagggggtat     4680

ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg     4740

accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc     4800

gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg gcatcccttt agggttccga     4860

tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt     4920

gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat     4980

agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat     5040

ttataaggga ttttggggat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa     5100

tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct     5160

ccccaggcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga     5220

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     5280

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     5340

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctctgcc     5400

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     5460

ctcccgggag cttgtatatc cattttcgga tctgatcaag agacaggatg aggatcgttt     5520

cgcatgattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta     5580

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg     5640

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa     5700

ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct     5760

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg     5820

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca     5880

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat     5940

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac     6000

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc     6060

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa     6120

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag     6180

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc     6240

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt     6300

cttgacgagt tcttctgagc gggactctgg ggttcgaaat gaccgaccaa gcgacgccca     6360

acctgccatc acgagatttc gattccaccg ccgccttcta tgaaaggttg ggcttcggaa     6420

tcgttttccg ggacgccggc tggatgatcc tccagcgcgg ggatctcatg ctggagttct     6480

tcgcccaccc caacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     6540

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     6600

tcaatgtatc ttatcatgtc tgtataccgt cgacctctag ctagagcttg gcgtaatcat     6660

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     6720

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     6780

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     6840

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     6900

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     6960

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     7020

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     7080

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     7140

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     7200

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat     7260

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     7320

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     7380

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     7440

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     7500

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     7560

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     7620

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     7680

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     7740

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     7800

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     7860

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     7920

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     7980

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     8040

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     8100

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     8160

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     8220

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     8280

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     8340

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     8400

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     8460

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     8520

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     8580

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     8640

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcatt     8700

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     8760

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtc      8819


<210>  1808
<211>  8729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-nCas3-10aa-FokI

<400>  1808
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggct gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggg gggcagcgga agtagtggcg ggagtgggca     3660

gctggtgaag tccgagctgg aggagaagaa gagcgagctg cgccacaagc tgaagtacgt     3720

gccccacgag tatatcgagc tgatcgagat cgccaggaat cctacccagg atcgcatcct     3780

ggagatgaaa gtgatggagt tctttatgaa ggtgtacggc tataggggag agcacctggg     3840

aggcagccgc aagcctgacg gcgccatcta cacagtgggc tccccaatcg actatggcgt     3900

gatcgtggat accaaggcct acagcggcgg ctataacctg ccaatcggac aggcagacga     3960

gatgcagcgg tacgtggagg agaaccagac aagaaataag cacatcaacc caaatgagtg     4020

gtggaaggtg tatccctcct ctgtgaccga gttcaagttt ctgttcgtgt ccggccactt     4080

taagggcaac tacaaggccc agctgacacg gctgaatcac atcaccaact gtaatggcgc     4140

cgtgctgtct gtggaggagc tgctgatcgg cggcgagatg atcaaggccg gcaccctgac     4200

actggaggag gtgagaagga agtttaacaa tggcgagatc aatttctaac attggaagtg     4260

gataatctag agggccctat tctatagtgt cacctaaatg ctagagctcg ctgatcagcc     4320

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     4380

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4440

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4500

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     4560

gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc     4620

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4680

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4740

ctaaatcggg gcatcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4800

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4860

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     4920

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttggggat ttcggcctat     4980

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt     5040

gtcagttagg gtgtggaaag tccccaggct ccccaggcag gcagaagtat gcaaagcatg     5100

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     5160

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     5220

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     5280

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     5340

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     5400

tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     5460

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     5520

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     5580

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     5640

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     5700

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     5760

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     5820

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     5880

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     5940

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     6000

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     6060

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     6120

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     6180

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg     6240

ggttcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg     6300

ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc     6360

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     6420

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     6480

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt     6540

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     6600

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     6660

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     6720

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     6780

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     6840

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     6900

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     6960

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     7020

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     7080

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     7140

tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc agttcggtgt     7200

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     7260

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     7320

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     7380

tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc     7440

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     7500

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     7560

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     7620

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     7680

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     7740

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     7800

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     7860

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     7920

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     7980

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     8040

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     8100

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     8160

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     8220

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     8280

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     8340

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     8400

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     8460

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     8520

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     8580

gttgaatact catactcttc ctttttcatt attattgaag catttatcag ggttattgtc     8640

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     8700

catttccccg aaaagtgcca cctgacgtc                                       8729


<210>  1809
<211>  8750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-nCas3-17aa-FokI

<400>  1809
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggct gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggc tgacccaact aacagagcta agggcctgga     3660

ggccgtatct gtggcatcac agctggtgaa gtccgagctg gaggagaaga agagcgagct     3720

gcgccacaag ctgaagtacg tgccccacga gtatatcgag ctgatcgaga tcgccaggaa     3780

tcctacccag gatcgcatcc tggagatgaa agtgatggag ttctttatga aggtgtacgg     3840

ctatagggga gagcacctgg gaggcagccg caagcctgac ggcgccatct acacagtggg     3900

ctccccaatc gactatggcg tgatcgtgga taccaaggcc tacagcggcg gctataacct     3960

gccaatcgga caggcagacg agatgcagcg gtacgtggag gagaaccaga caagaaataa     4020

gcacatcaac ccaaatgagt ggtggaaggt gtatccctcc tctgtgaccg agttcaagtt     4080

tctgttcgtg tccggccact ttaagggcaa ctacaaggcc cagctgacac ggctgaatca     4140

catcaccaac tgtaatggcg ccgtgctgtc tgtggaggag ctgctgatcg gcggcgagat     4200

gatcaaggcc ggcaccctga cactggagga ggtgagaagg aagtttaaca atggcgagat     4260

caatttctaa cattggaagt ggataatcta gagggcccta ttctatagtg tcacctaaat     4320

gctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc     4380

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4440

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4500

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4560

ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg     4620

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4680

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4740

gccggctttc cccgtcaagc tctaaatcgg ggcatccctt tagggttccg atttagtgct     4800

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     4860

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     4920

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     4980

attttgggga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5040

aattaattct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccaggca     5100

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca     5160

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc     5220

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     5280

catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta     5340

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga     5400

gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt tcgcatgatt     5460

gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat     5520

gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag     5580

gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac     5640

gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac     5700

gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc     5760

ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg     5820

ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag     5880

cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat     5940

caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag     6000

gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc     6060

ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg     6120

ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg     6180

ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag     6240

ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat     6300

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc     6360

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc     6420

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     6480

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     6540

cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc     6600

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca     6660

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct     6720

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac     6780

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     6840

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     6900

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     6960

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     7020

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     7080

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     7140

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct     7200

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     7260

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     7320

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     7380

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     7440

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     7500

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     7560

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     7620

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     7680

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     7740

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     7800

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     7860

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     7920

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     7980

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     8040

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     8100

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     8160

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     8220

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     8280

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     8340

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     8400

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     8460

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     8520

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     8580

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcat tattattgaa     8640

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     8700

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc                8750


<210>  1810
<211>  8789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-nCas3-30aa-FokI

<400>  1810
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggct gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaagag cggctccgaa acgccgggta catccgagtc     3660

cgcgactcct gagtcaggag gcagcggctc ctctggtgga agcggctcaa gtggagggca     3720

gctggtgaag tccgagctgg aggagaagaa gagcgagctg cgccacaagc tgaagtacgt     3780

gccccacgag tatatcgagc tgatcgagat cgccaggaat cctacccagg atcgcatcct     3840

ggagatgaaa gtgatggagt tctttatgaa ggtgtacggc tataggggag agcacctggg     3900

aggcagccgc aagcctgacg gcgccatcta cacagtgggc tccccaatcg actatggcgt     3960

gatcgtggat accaaggcct acagcggcgg ctataacctg ccaatcggac aggcagacga     4020

gatgcagcgg tacgtggagg agaaccagac aagaaataag cacatcaacc caaatgagtg     4080

gtggaaggtg tatccctcct ctgtgaccga gttcaagttt ctgttcgtgt ccggccactt     4140

taagggcaac tacaaggccc agctgacacg gctgaatcac atcaccaact gtaatggcgc     4200

cgtgctgtct gtggaggagc tgctgatcgg cggcgagatg atcaaggccg gcaccctgac     4260

actggaggag gtgagaagga agtttaacaa tggcgagatc aatttctaac attggaagtg     4320

gataatctag agggccctat tctatagtgt cacctaaatg ctagagctcg ctgatcagcc     4380

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     4440

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4500

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4560

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     4620

gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc     4680

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4740

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4800

ctaaatcggg gcatcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4860

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4920

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     4980

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttggggat ttcggcctat     5040

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt     5100

gtcagttagg gtgtggaaag tccccaggct ccccaggcag gcagaagtat gcaaagcatg     5160

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     5220

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     5280

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     5340

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     5400

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     5460

tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     5520

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     5580

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     5640

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     5700

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     5760

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     5820

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     5880

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     5940

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     6000

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     6060

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     6120

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     6180

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     6240

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg     6300

ggttcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg     6360

ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc     6420

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     6480

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     6540

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt     6600

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     6660

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     6720

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     6780

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     6840

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     6900

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     6960

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     7020

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     7080

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     7140

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     7200

tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc agttcggtgt     7260

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     7320

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     7380

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     7440

tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc     7500

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     7560

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     7620

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     7680

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     7740

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     7800

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     7860

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     7920

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     7980

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     8040

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     8100

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     8160

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     8220

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     8280

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     8340

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     8400

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     8460

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     8520

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     8580

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     8640

gttgaatact catactcttc ctttttcatt attattgaag catttatcag ggttattgtc     8700

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     8760

catttccccg aaaagtgcca cctgacgtc                                       8789


<210>  1811
<211>  8819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-nCas3-40aa-FokI

<400>  1811
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggct gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaagag cggctccgaa acgccgggta catccgagtc     3660

cgcgactcct gagtcaggag gcagcggctc ctctggtgga agcggctcaa gtggagggag     3720

cggctcaagt ggtggaagcg gctcaagtca gctggtgaag tccgagctgg aggagaagaa     3780

gagcgagctg cgccacaagc tgaagtacgt gccccacgag tatatcgagc tgatcgagat     3840

cgccaggaat cctacccagg atcgcatcct ggagatgaaa gtgatggagt tctttatgaa     3900

ggtgtacggc tataggggag agcacctggg aggcagccgc aagcctgacg gcgccatcta     3960

cacagtgggc tccccaatcg actatggcgt gatcgtggat accaaggcct acagcggcgg     4020

ctataacctg ccaatcggac aggcagacga gatgcagcgg tacgtggagg agaaccagac     4080

aagaaataag cacatcaacc caaatgagtg gtggaaggtg tatccctcct ctgtgaccga     4140

gttcaagttt ctgttcgtgt ccggccactt taagggcaac tacaaggccc agctgacacg     4200

gctgaatcac atcaccaact gtaatggcgc cgtgctgtct gtggaggagc tgctgatcgg     4260

cggcgagatg atcaaggccg gcaccctgac actggaggag gtgagaagga agtttaacaa     4320

tggcgagatc aatttctaac attggaagtg gataatctag agggccctat tctatagtgt     4380

cacctaaatg ctagagctcg ctgatcagcc tcgactgtgc cttctagttg ccagccatct     4440

gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt     4500

tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg     4560

ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg     4620

gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc tagggggtat     4680

ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg     4740

accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc     4800

gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg gcatcccttt agggttccga     4860

tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt     4920

gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat     4980

agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat     5040

ttataaggga ttttggggat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa     5100

tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct     5160

ccccaggcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga     5220

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     5280

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     5340

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctctgcc     5400

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     5460

ctcccgggag cttgtatatc cattttcgga tctgatcaag agacaggatg aggatcgttt     5520

cgcatgattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta     5580

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg     5640

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa     5700

ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct     5760

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg     5820

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca     5880

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat     5940

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac     6000

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc     6060

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa     6120

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag     6180

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc     6240

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt     6300

cttgacgagt tcttctgagc gggactctgg ggttcgaaat gaccgaccaa gcgacgccca     6360

acctgccatc acgagatttc gattccaccg ccgccttcta tgaaaggttg ggcttcggaa     6420

tcgttttccg ggacgccggc tggatgatcc tccagcgcgg ggatctcatg ctggagttct     6480

tcgcccaccc caacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     6540

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     6600

tcaatgtatc ttatcatgtc tgtataccgt cgacctctag ctagagcttg gcgtaatcat     6660

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     6720

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     6780

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     6840

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     6900

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     6960

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     7020

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     7080

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     7140

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     7200

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat     7260

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     7320

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     7380

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     7440

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     7500

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     7560

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     7620

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     7680

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     7740

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     7800

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     7860

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     7920

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     7980

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     8040

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     8100

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     8160

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     8220

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     8280

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     8340

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     8400

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     8460

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     8520

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     8580

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     8640

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcatt     8700

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     8760

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtc      8819


<210>  1812
<211>  8729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-dCas3-10aa-FokI

<400>  1812
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgcca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggg gggcagcgga agtagtggcg ggagtgggca     3660

gctggtgaag tccgagctgg aggagaagaa gagcgagctg cgccacaagc tgaagtacgt     3720

gccccacgag tatatcgagc tgatcgagat cgccaggaat cctacccagg atcgcatcct     3780

ggagatgaaa gtgatggagt tctttatgaa ggtgtacggc tataggggag agcacctggg     3840

aggcagccgc aagcctgacg gcgccatcta cacagtgggc tccccaatcg actatggcgt     3900

gatcgtggat accaaggcct acagcggcgg ctataacctg ccaatcggac aggcagacga     3960

gatgcagcgg tacgtggagg agaaccagac aagaaataag cacatcaacc caaatgagtg     4020

gtggaaggtg tatccctcct ctgtgaccga gttcaagttt ctgttcgtgt ccggccactt     4080

taagggcaac tacaaggccc agctgacacg gctgaatcac atcaccaact gtaatggcgc     4140

cgtgctgtct gtggaggagc tgctgatcgg cggcgagatg atcaaggccg gcaccctgac     4200

actggaggag gtgagaagga agtttaacaa tggcgagatc aatttctaac attggaagtg     4260

gataatctag agggccctat tctatagtgt cacctaaatg ctagagctcg ctgatcagcc     4320

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     4380

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4440

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4500

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     4560

gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc     4620

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4680

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4740

ctaaatcggg gcatcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4800

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4860

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     4920

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttggggat ttcggcctat     4980

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt     5040

gtcagttagg gtgtggaaag tccccaggct ccccaggcag gcagaagtat gcaaagcatg     5100

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     5160

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     5220

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     5280

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     5340

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     5400

tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca     5460

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     5520

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     5580

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     5640

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     5700

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     5760

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     5820

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     5880

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     5940

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     6000

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     6060

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     6120

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     6180

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg     6240

ggttcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg     6300

ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc     6360

tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt     6420

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     6480

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt     6540

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     6600

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     6660

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     6720

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     6780

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     6840

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     6900

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     6960

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     7020

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     7080

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     7140

tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc agttcggtgt     7200

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     7260

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     7320

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     7380

tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc     7440

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     7500

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     7560

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     7620

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     7680

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     7740

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     7800

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     7860

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     7920

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     7980

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     8040

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     8100

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     8160

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     8220

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     8280

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     8340

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     8400

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     8460

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     8520

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     8580

gttgaatact catactcttc ctttttcatt attattgaag catttatcag ggttattgtc     8640

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     8700

catttccccg aaaagtgcca cctgacgtc                                       8729


<210>  1813
<211>  8750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-dCas3-17aa-FokI

<400>  1813
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgcca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggc tgacccaact aacagagcta agggcctgga     3660

ggccgtatct gtggcatcac agctggtgaa gtccgagctg gaggagaaga agagcgagct     3720

gcgccacaag ctgaagtacg tgccccacga gtatatcgag ctgatcgaga tcgccaggaa     3780

tcctacccag gatcgcatcc tggagatgaa agtgatggag ttctttatga aggtgtacgg     3840

ctatagggga gagcacctgg gaggcagccg caagcctgac ggcgccatct acacagtggg     3900

ctccccaatc gactatggcg tgatcgtgga taccaaggcc tacagcggcg gctataacct     3960

gccaatcgga caggcagacg agatgcagcg gtacgtggag gagaaccaga caagaaataa     4020

gcacatcaac ccaaatgagt ggtggaaggt gtatccctcc tctgtgaccg agttcaagtt     4080

tctgttcgtg tccggccact ttaagggcaa ctacaaggcc cagctgacac ggctgaatca     4140

catcaccaac tgtaatggcg ccgtgctgtc tgtggaggag ctgctgatcg gcggcgagat     4200

gatcaaggcc ggcaccctga cactggagga ggtgagaagg aagtttaaca atggcgagat     4260

caatttctaa cattggaagt ggataatcta gagggcccta ttctatagtg tcacctaaat     4320

gctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc     4380

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4440

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4500

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4560

ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg     4620

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4680

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4740

gccggctttc cccgtcaagc tctaaatcgg ggcatccctt tagggttccg atttagtgct     4800

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     4860

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     4920

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     4980

attttgggga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5040

aattaattct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccaggca     5100

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca     5160

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc     5220

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     5280

catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta     5340

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga     5400

gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt tcgcatgatt     5460

gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat     5520

gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag     5580

gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac     5640

gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac     5700

gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc     5760

ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg     5820

ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag     5880

cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat     5940

caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag     6000

gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc     6060

ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg     6120

ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg     6180

ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag     6240

ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat     6300

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc     6360

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc     6420

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     6480

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     6540

cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc     6600

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca     6660

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct     6720

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac     6780

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     6840

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     6900

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     6960

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     7020

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     7080

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     7140

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct     7200

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     7260

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     7320

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     7380

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     7440

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     7500

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     7560

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     7620

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     7680

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     7740

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     7800

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     7860

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     7920

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     7980

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     8040

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     8100

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     8160

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     8220

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     8280

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     8340

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     8400

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     8460

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     8520

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     8580

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcat tattattgaa     8640

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     8700

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc                8750


<210>  1814
<211>  8750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-dCas3-30aa-FokI

<400>  1814
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgcca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaaggc tgacccaact aacagagcta agggcctgga     3660

ggccgtatct gtggcatcac agctggtgaa gtccgagctg gaggagaaga agagcgagct     3720

gcgccacaag ctgaagtacg tgccccacga gtatatcgag ctgatcgaga tcgccaggaa     3780

tcctacccag gatcgcatcc tggagatgaa agtgatggag ttctttatga aggtgtacgg     3840

ctatagggga gagcacctgg gaggcagccg caagcctgac ggcgccatct acacagtggg     3900

ctccccaatc gactatggcg tgatcgtgga taccaaggcc tacagcggcg gctataacct     3960

gccaatcgga caggcagacg agatgcagcg gtacgtggag gagaaccaga caagaaataa     4020

gcacatcaac ccaaatgagt ggtggaaggt gtatccctcc tctgtgaccg agttcaagtt     4080

tctgttcgtg tccggccact ttaagggcaa ctacaaggcc cagctgacac ggctgaatca     4140

catcaccaac tgtaatggcg ccgtgctgtc tgtggaggag ctgctgatcg gcggcgagat     4200

gatcaaggcc ggcaccctga cactggagga ggtgagaagg aagtttaaca atggcgagat     4260

caatttctaa cattggaagt ggataatcta gagggcccta ttctatagtg tcacctaaat     4320

gctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc     4380

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4440

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4500

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4560

ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg     4620

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4680

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4740

gccggctttc cccgtcaagc tctaaatcgg ggcatccctt tagggttccg atttagtgct     4800

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     4860

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     4920

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     4980

attttgggga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5040

aattaattct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccaggca     5100

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca     5160

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc     5220

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     5280

catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta     5340

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga     5400

gcttgtatat ccattttcgg atctgatcaa gagacaggat gaggatcgtt tcgcatgatt     5460

gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat     5520

gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag     5580

gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac     5640

gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac     5700

gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc     5760

ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg     5820

ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag     5880

cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat     5940

caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag     6000

gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc     6060

ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg     6120

ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg     6180

ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag     6240

ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat     6300

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc     6360

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc     6420

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     6480

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     6540

cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc     6600

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca     6660

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct     6720

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac     6780

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     6840

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     6900

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     6960

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     7020

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     7080

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     7140

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct     7200

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     7260

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     7320

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     7380

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     7440

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     7500

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     7560

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     7620

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     7680

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     7740

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     7800

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     7860

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     7920

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     7980

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     8040

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     8100

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     8160

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     8220

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     8280

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     8340

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     8400

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     8460

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     8520

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     8580

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcat tattattgaa     8640

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     8700

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc                8750


<210>  1815
<211>  8819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: NLS-dCas3-40aa-FokI

<400>  1815
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatgc cacccccaag aaaaagagaa aagtaggatc      960

gggcatggag cccttcaagt acatctgcca ctattggggc aagagctcca agagcctgac     1020

aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag cagtggcaga     1080

ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg agatgctgag     1140

caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgcca tcggcaagtt     1200

cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc cagccacacc     1260

cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg cagcaggact     1320

gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct tttctttctt     1380

tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag tgacaggaca     1440

ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga tgccagccag     1500

cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct ccgtgctgga     1560

ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg actgctctag     1620

cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca caaccaatac     1680

attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct acttccagga     1740

taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta ataagcggtg     1800

ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc tgcaggtgct     1860

ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta ccggctccgg     1920

caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga tcgccgactc     1980

tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca ggatggaggc     2040

ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca acagccggtt     2100

caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac aggaggaggc     2160

ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc tgggccagat     2220

cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc acaggtttat     2280

caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg cctacgacac     2340

atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg gcggctctgt     2400

gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg atacatacgg     2460

cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt ggaggggagt     2520

gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac cacggttttc     2580

catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca tgctggagag     2640

aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc tggtggatgt     2700

ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg acatcgatct     2760

gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg tgatcagcaa     2820

cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac aggtggtgga     2880

gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg ccgatctgct     2940

gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg caggattcga     3000

gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc acgagcacat     3060

ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc tgaacggcgc     3120

cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg acgatgccga     3180

gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg ccgagtgtga     3240

gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc tgcaggataa     3300

cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac tgctgcctta     3360

tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg acctgagcca     3420

cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca cctggaagcg     3480

gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca agcagaatct     3540

ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg acgagggcat     3600

gaccagagtg atcccagcca accccaagag cggctccgaa acgccgggta catccgagtc     3660

cgcgactcct gagtcaggag gcagcggctc ctctggtgga agcggctcaa gtggagggag     3720

cggctcaagt ggtggaagcg gctcaagtca gctggtgaag tccgagctgg aggagaagaa     3780

gagcgagctg cgccacaagc tgaagtacgt gccccacgag tatatcgagc tgatcgagat     3840

cgccaggaat cctacccagg atcgcatcct ggagatgaaa gtgatggagt tctttatgaa     3900

ggtgtacggc tataggggag agcacctggg aggcagccgc aagcctgacg gcgccatcta     3960

cacagtgggc tccccaatcg actatggcgt gatcgtggat accaaggcct acagcggcgg     4020

ctataacctg ccaatcggac aggcagacga gatgcagcgg tacgtggagg agaaccagac     4080

aagaaataag cacatcaacc caaatgagtg gtggaaggtg tatccctcct ctgtgaccga     4140

gttcaagttt ctgttcgtgt ccggccactt taagggcaac tacaaggccc agctgacacg     4200

gctgaatcac atcaccaact gtaatggcgc cgtgctgtct gtggaggagc tgctgatcgg     4260

cggcgagatg atcaaggccg gcaccctgac actggaggag gtgagaagga agtttaacaa     4320

tggcgagatc aatttctaac attggaagtg gataatctag agggccctat tctatagtgt     4380

cacctaaatg ctagagctcg ctgatcagcc tcgactgtgc cttctagttg ccagccatct     4440

gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt     4500

tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg     4560

ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg     4620

gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc tagggggtat     4680

ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg     4740

accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc     4800

gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg gcatcccttt agggttccga     4860

tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt     4920

gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat     4980

agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat     5040

ttataaggga ttttggggat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa     5100

tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct     5160

ccccaggcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga     5220

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     5280

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     5340

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctctgcc     5400

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     5460

ctcccgggag cttgtatatc cattttcgga tctgatcaag agacaggatg aggatcgttt     5520

cgcatgattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta     5580

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg     5640

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa     5700

ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct     5760

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg     5820

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca     5880

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat     5940

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac     6000

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc     6060

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa     6120

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag     6180

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc     6240

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt     6300

cttgacgagt tcttctgagc gggactctgg ggttcgaaat gaccgaccaa gcgacgccca     6360

acctgccatc acgagatttc gattccaccg ccgccttcta tgaaaggttg ggcttcggaa     6420

tcgttttccg ggacgccggc tggatgatcc tccagcgcgg ggatctcatg ctggagttct     6480

tcgcccaccc caacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     6540

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     6600

tcaatgtatc ttatcatgtc tgtataccgt cgacctctag ctagagcttg gcgtaatcat     6660

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     6720

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     6780

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     6840

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     6900

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     6960

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     7020

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     7080

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     7140

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     7200

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat     7260

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     7320

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     7380

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     7440

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     7500

gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     7560

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     7620

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     7680

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     7740

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     7800

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     7860

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     7920

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     7980

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     8040

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     8100

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     8160

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     8220

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     8280

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     8340

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     8400

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     8460

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     8520

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     8580

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     8640

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcatt     8700

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     8760

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtc      8819


<210>  1816
<211>  5169
<212>  DNA
<213>  Fusobacterium nucleatum

<400>  1816
atgggcccca agaagaagag aaaggtaggc agcggcatgg agaagagagt gtacggcatc       60

ctgggcatca gctccatcat gtccaattgg aacgccgatt tctctggcga gcctaagtct      120

atcagcaatg gcagaatctt tggctccgac aaggccttca agtacccaat gaagaagatg      180

tgggagaacc agggcgagaa ggtgctgtat atcaagtctc tgaaggtgga taagggcgcc      240

ctgatcccca agaccctgaa ggagaggtac gagcagctgt ttcctgagaa gaagctggat      300

aagaacaccg agacaatcga agtgatcaag aatctgttca aggccatcga cgtgaagaac      360

tttggcgcca ccttcgccga ggagggcaac aatatcagca tcacaggcgc cgtgcagatc      420

ggccagggct tcaactttta cgacgagagc aataccgagg tgcaggatat cctgtccccc      480

ttcagagacc ctaagggcaa gatcaacaag gagacaaagg agaacgagga tgccaagaat      540

agcaccctgg gcacaaagat cgtgtccgac gaggcccact acttttatcc attcaatatc      600

aaccccctgg cctacaagga gtttatcgag ctggagatca ccgatggcta cacagaggag      660

gactatctga agttcaagga ggccgccctg tctagcgcca ccttctttgc cacaaactcc      720

aaagtgggct gcgataatga gtttggcctg ttcatcgaga ccgaggagga cttttacctg      780

ccaatcctga cacagtatat caagttcgag aagggcgagg agaagaacaa gatcaccctg      840

aatctgtcta caatcctgaa gggcgtggag aaccacatca agaatatcga gatctactat      900

aatcccgtga ccacagagat cgtgaccgat atcagcaact acaagctgat caatatcctg      960

acaaagaagg aagtgggctc tggcgaggga aggggcagcc tgctgacctg tggcgacgtg     1020

gaggagaacc ctggacctcc taaaaagaaa cgaaaggtag gctctggcat ggaggtgtac     1080

gagatgaagc tgaaggtgaa gctgaagaag gatatctttc tgaaggacgt gagcacctat     1140

atcacaagat tcatggatat gaacctgtcc gccaatccaa ccatgtacaa ctatcacaca     1200

tctaagatct acaagggcta tacctttgac ggcctgttcc ccatcgagga ggataagatc     1260

tacaagaagg acaagaccta tagctttcgg gtgagaacaa tcaaccagaa gatcgccaat     1320

tacttcctgg ataccctgat gttctttgag aataaggaca tccagggcct gacactgaac     1380

atcagagtga tcgagaagaa gctgatcgag aagctgtaca ccatcacacc tatcctgatg     1440

aagaccgatg agggctactg gcggtattct atgacatttg aggagttcga gaagagactg     1500

aagatcaact gcctgaagaa gtacctgtat ttcaccgaga acaatgacga tatcaccatc     1560

gacacagagc tgctgaagaa gctgggcgag gataagagcg acgatatcga cctgtttaca     1620

aacatcaagt tcatcaatag gatgcccgtg cctatcatct acaagggccg caagctggtg     1680

ggcgataagg tggagctgca ggtggccaac aatgagaagg cccaggacat cgcctatatg     1740

ctgctgggaa ccggactgct ggagaattgc gcacggggct gtggctttct gaacttcaag     1800

aattacgagg gctccggcga gggaagaggc tctctgctga cctgtggcga tgtggaggag     1860

aaccctggac ctccaaagaa gaaaagaaaa gtcggctccg gcatggaggc cctgaagttt     1920

acactgagcg gcaattccgc cttctttaag gacaacgtga tcaataccgt gtacctgaca     1980

tatggcaaca tccacagggt ggccctgctg ggcatgtttg gcgccatcct gggctacggc     2040

ggctattcta agcagaacga catgctgaag aagaagaaca agaagatgcc agattacccc     2100

gagttctatg agaagctgaa ggacatcaag atctctatcg tgagcaacgg caagaatggc     2160

tactttaata agaagctgca gaccttcaac aatagcgtgg gctatgcctc caaggaggag     2220

ggcggcaatc tgatcgtgaa gcagttctgg ctggagaacc cctcctggga tatctacatc     2280

ctgctggact gcgatgaggc caagaagatc gccgactata tccagaaccg caaggccatc     2340

tacctgcctt atctgggctc caacgatcac ctggccaata tcatggatgt ggagatcatc     2400

gacatcgagg agaagatgtc ctctgaggac gagaccatcg agatcctgtc tatggtgaag     2460

gactccgata tctctgagaa gaagaagaac gtgttcagca tcgacaaaaa tagcatccgg     2520

gacgatatct acaagtattc tgagtacctg cctgtgacac tgagcaagga gctgaatcag     2580

tatgagaagg agaagatgac catcacaaac atgagcgtga tcctgaagaa gtcctactat     2640

aaggtggagg ataagaatat cgtgttctac ggctctggcg aaggcagagg cagcctgctg     2700

acttgcggcg acgtggaaga gaaccctgga cctcccaaga aaaagaggaa agtgggcggc     2760

tcccagctgg tgaagtctga gctggaggag aagaagagcg agctgaggca caagctgaag     2820

tacgtgccac acgagtatat cgagctgatc gagatcgcca ggaaccccac ccaggatcgc     2880

atcctggaga tgaaagtgat ggagttcttt atgaaggtgt acggatatag gggagagcac     2940

ctgggaggca gcagaaagcc tgacggagcc atctacaccg tgggctcccc aatcgattat     3000

ggcgtgatcg tggacacaaa ggcctactcc ggcggctata acctgccaat cggccaggcc     3060

gacgagatgc agaggtacgt ggaggagaac cagacccgca ataagcacat caatcctaac     3120

gagtggtgga aggtgtatcc aagctccgtg acagagttca agtttctgtt cgtgagcggc     3180

cacttcaagg gcaattacaa ggcccagctg acccgcctga accacatcac aaattgcaac     3240

ggagccgtgc tgtccgtgga ggagctgctg atcggcggcg agatgatcaa ggcaggcacc     3300

ctgacactgg aggaggtgcg gagaaagttt aacaatggcg agatcaactt ctctgctagc     3360

gagacacctg gcacctccga gtctgccacc ccagagtccg gcggctctgg ctctagcggc     3420

ggctctggct cctccggagg aatgatcgat gaggccctgg aggtgtttaa gaagatctac     3480

gacaaggagg gcgagaagct ggtggtgaat aagcacatcc ccaaggacgg cacatatatc     3540

ctggtgaata tcaagtctgg caagatcatc gagaagctga acatcttcta cgataagaag     3600

agcaagaaga tcgacggcga gctgaaccag tactatggct attttcgcgc cttcgattac     3660

tatagcaacc tggtggatat gaataagcct atggacccaa agaagaccat ccacagcaat     3720

cagatctatt ccttctttat caagaaggac tctatccggg agaacaagct gacaaagagc     3780

atcatcgagg gctacaagaa gaacctgctg aatcctgagg agaagtacaa ttccaaggag     3840

ggcaaggagc tgtataagaa catcgccgag aagctgccaa agatcgagaa ggatatcgtg     3900

gaggacatct tcctgtggat cgaggacaat gtgaacgaga atctgctgga gaacgataat     3960

aagaaggact atctgaagat cttctttgtg gaggaggacc tggataagag cctggagctg     4020

tttaagaacg agcacaagag gtacatcatc cctaacatct tcaactccaa cgattacaat     4080

aagaagatcg gcgagaccat ctatggcctg tctaacaata acatgggcct gaacgccaag     4140

aaggcctttc tggagaataa gaccaggcgc gtgagcacac cctacctggt gaatacagac     4200

gagatcctgc tgcagtatgc cttctacaac tatctgctgc ctgaggtgaa gcagggcaac     4260

tactttatct atttctccga gaatgagatc atcccaagaa cctacaagga gggctgcccc     4320

aacggcgcca agtacctgct gaatgcctct tatagcaagg acgtggatat caagaacttt     4380

aatgtgatct ccaagaatag ctccgaggag atcaacatca atttcaagga gatcctgcac     4440

cagaagaaga aggacacaga tgagatcgag tacggcaacc tgaataggga gaagatgatg     4500

aacaacatca acaagatcct gttttataac tccctgctgg gcaatttcct gctgtctgac     4560

ggcgatctgg acatcaagga tatcgagatc aagaagctgc tgatgaagta ccgcaatgcc     4620

ttttacaagt ggttctatct gaacgatgag gccgaggtga agaagaatat cagaaagatc     4680

tacctggacg ccgtgatggt ggccatcggc aacggctatt tctttaaggc cagccagcag     4740

ctggactttg gcttctgtct ggagaagtac ttctatggca agtccgagct gatggaggag     4800

atcatgaacg tgaaagaggt gtttctgaat cacaccctga gcgaggagga ttgggagttc     4860

ctgaacgacg aggagtactt ctttgccgtg ggccagatcc tggcctacat caactatatg     4920

cgcaattcca aggccaagag cctgaacttc atcaagcagc tgacattcgt gaagaacatc     4980

gacgtgctga aggagaagat caagaagatc gtgatctcct attctcacat ctttgagacc     5040

aagaacaaga agatcaatag gacagtgtct aacatcagcc tgtaccagcc aaaggagatc     5100

cgcatcgata tcctgctggc cggcttcacc gccgacatca tcttctttaa gaagcgggag     5160

gagaagtga                                                             5169


<210>  1817
<211>  4791
<212>  DNA
<213>  Klebsiella oxytoca

<400>  1817
atgggcccca agaagaagag aaaggtaggc agcggcatgg caaaggcacc cgtgtctgtg       60

aagaccgcca gcgtgctggc ctttgagagg aagctggcca catccgacgc catgatgtac      120

gccggcaact ggctgggcga ttcttggcag cctatcgaga tcaaggagaa ggccgtgagg      180

ggcaccatca gcaatcgcct gaagaacgcc atcgcctccg acgccacaaa gctggatgcc      240

gagatccaga aggcaaatct gcagcgggtg gacaccgccg ccctgccagc cgacgccgat      300

accctgaagg tggtgttcac actgagagtg ctgggaaacc tggcaacccc aagcgtgtgc      360

aatgatatgg cctaccagaa cgccatccag cagacaatcg agggctatat cagcgagcac      420

ggatttgcag agctggcccg gagatacgcc gccaatctgg ccaacggcag attcctgtgg      480

cggaatagaa tcggcgccga gcagatccag gtgtctgtga gcgcccaggg acaggcctgg      540

gtgtttaacg gccacgacta ttccctgagg gagttctctc aggacgatga ggagatcgcc      600

tctctggccg ccctgatcga gcagggactg agcggccagg cctgggtcat gctgaccgtg      660

gaggcacagg tgcggctggg agcaggccag gaggtgtttc catctcagga gctggtgctg      720

gatagcaata gctccaagtc ccgcgtgctg taccaggtgg caggaatcgc aggcatccac      780

agccagaaga tcggcaacgc cctgcggaca atcgacacct ggcaccccaa ggtggatgag      840

ctgggagcaa tcgcagtgga gccttacggc agcgtgacct cccgcggaat ggcatgcagg      900

cagcccaagg acaagatgga cttctacacc ctgctggact cctgggtgac aaagggcatc      960

aagcctgatg tggagcagca gcactacgtg atggccgtgc tgatcagggg aggcgtgttc     1020

ggcgagaagt ctgagggcag cggcgaggga aggggcagcc tgctgacatg tggcgacgtg     1080

gaggagaacc ctggacctcc taaaaagaaa cgaaaggtag gcagcggcat ggactacttc     1140

ctggatatca gagtgctgcc agaccccgag ttttccgagg agatgctgat ggccgccctg     1200

ttcgccaagc tgcacagagc cctgggagca aggggcaagg gcgatatcgg cgtgtctttt     1260

ccagagttca gcgtgaagcc tggaccactg ctgaggctgc acggcgacga gtccgccctg     1320

tgcgccctgg aggagaccct gtggagaaag ggcctgaatg attattgtca gtctggccag     1380

atcatgcctg tggaggagat caagggatgg agatgcgtga gccgggtgca ggtgaagtct     1440

agcccagaga ggctgatgag gcgcagcgtg cgcaagggat ggctgaccca ggacgaggca     1500

aacgagcgcc tgctgtccat gaggggagag tctacagccc tgccttggct gaatatgaag     1560

tccctgtcta acggccagaa gtttccactg ttcatctgcc acggagagct gctggcccag     1620

cgcgtggcag gcacctttaa ttcttacggc ctgagccaca tcgccacaat cccttggttc     1680

ggctctggcg aaggcagggg cagcctgctg acctgtggcg atgtggagga gaaccctgga     1740

cctccaaaga agaaaagaaa agtcggctcc ggcatgtctt acctgctgct gctgccccac     1800

atccgcatcg agaatgcaaa cgcagtggca ggactgacct ggggatttcc tgccatcaca     1860

cacttcctgg gctatgtgca cgccctgtcc cggagagtgt ctgagtttgg cgtgtccttc     1920

accggctgcg ccgtgatcaa tcacgagcac cacatccagg cctactcctc tggccgggac     1980

tatcagtttg ccctgacaag aaatcctctg accaaggagg gcaagacagc cgccttcaac     2040

gaggagggca gaatgcacct gaccgtgagc ctgctggtgg agtgtcaggg cgagatcatc     2100

aatggagagt acggcaaggc cgccctgtgc agctccctgc tgaccctgtg ccagagccac     2160

aagctggccg gaggctccat cgtgatgatg agggagccac agatctttaa cgcccccgac     2220

gatgagagga ccctgcgcaa gatcctgtgg aggctgatgc caggattcgc actgtgcgat     2280

aggtccgagt ggctgatgga gcactacagg cagctgcagc agaggcgccc tgagtctagc     2340

ctgctggacg cctggctgga tttcgccgcc atcaagtatc agcctgtgca gcaggagcca     2400

gaggacagca tgtcctggga gtaccagccc aagcctaagc caggctatct ggtgcccctg     2460

atgtgcggct accagcggat cagcagactg tatcagccag gcgaggtggc caacgtgagg     2520

gataccacaa cccccttcgc ctttaccgag gccgtgtacg gagtgggaga gtggagagga     2580

ctgcacagga tcgccgacct ggagccactg atctggaggt atcgcacatc tgataccggc     2640

tactattgca gcgccatgcc cgtggccgac gatgacttca tctttaatga ggatgacgat     2700

ctggagggct ccggcgaggg aaggggctct ctgctgacct gcggcgacgt ggaagagaac     2760

cctggacctc ccaagaaaaa gaggaaagtg ggcggcagcc agctggtgaa gtccgagctg     2820

gaggagaaga agtccgagct gaggcacaag ctgaagtacg tgcctcacga gtatatcgag     2880

ctgatcgaga tcgcccggaa tccaacacag gacagaatcc tggagatgaa agtgatggag     2940

ttctttatga aggtgtacgg atatagggga gagcacctgg gaggctctcg caagccagat     3000

ggagccatct acaccgtggg cagccccatc gactatggcg tgatcgtgga tacaaaggcc     3060

tacagcggcg gctataacct gccaatcgga caggcagacg agatgcagcg gtatgtggag     3120

gagaatcaga ccagaaacaa gcacatcaat cctaacgagt ggtggaaggt gtacccatcc     3180

tctgtgacag agttcaagtt tctgttcgtg tccggccact tcaagggcaa ttataaggcc     3240

cagctgaccc gcctgaacca catcacaaat tgcaacggcg ccgtgctgtc tgtggaggag     3300

ctgctgatcg gcggcgagat gatcaaggca ggcacactga ccctggagga ggtgcggaga     3360

aagtttaaca atggcgagat caatttctct gctagcgaga cacctggcac ctccgagtct     3420

gccaccccag agtccggcgg ctctggctct agcggcggct ctggctcctc cggaggaatg     3480

acaaccgagg ccctgacaca ctttatcatc gactacatcg cctcccggaa gcagccaaag     3540

ctggatgcct tcgagaagga ggccgccaag agactggccc agggagagga cgcaggagca     3600

atcgcccagg agaggcagga gctggaggtg aagtatcagc caaggaactg gctgaccgat     3660

gcagcaagga gggcaggaca gatcagcctg gtgacccacg ccgccaagtt cacacacggc     3720

gactccaagt cctctagcat ctacagagag accgtgggcg atgagggcta tctgtccaca     3780

gccgtgctgg ccaatgtggc agcagacgca gtgggaaacg cagccgccct ggatgtggca     3840

aagctgctgc agacagaagt gggaggcgac agcctgctgg cctgtctgaa gaggggcgat     3900

cgctccccac tgatgggctt tgccgagaat gacgcacagc tggccctgtg gatggagggc     3960

ttctcccagg ccctgacccc agcccagcct acatctcaca agctggccaa gcagatctac     4020

tttcctgtgg atggcggcta tcacctgctg agcccactgt tcgcctcctc tctggcccag     4080

gccatgcacg agaagatggt ggcagcaagg tttggagagc aggcaaaggc agcaagagag     4140

gcaaggagag ccggcaagtg gcacgcacag ccagacgtgc gctaccctaa cgtggccgag     4200

atgcacttcg gcggcaccaa gccccagaat atctccgccc tgaacagctc ccggggaggc     4260

agagtgtggc tgctgccctc tcagccccct aagtggacca tgctggacaa ggcccctcag     4320

aatctgacaa gcctgtttgc cctgagaggc gacttcaaca gggccgccac agataccgtg     4380

agccggatgg tgtccctgct gaaggagaag acagataaca ataacaggca catccgcaat     4440

gcaagggcag gatacgtgga cgagctgatc gatctgctgt ttctgcacgc cgccacctat     4500

cagcaggagg cctggcaggg ctggacactg aactccccag acctgccact gcaccagcag     4560

ctgtggctgg acccctggag gtccaagaca gatgagacct ttagatctga gagggagaag     4620

ggcgactggc agcgcagcgt ggcagacgat ttcgcaaggt ggctgaatta ccggctgaac     4680

aaggccagac tggatgtggg aatcgcagag aggagggagt ggcagaccca gcggctgttc     4740

agccagcgga tgagagagat ggaggccatc gtgcaggagg ccctgaagtg a              4791


<210>  1818
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hsa414 single target guide template primer

<400>  1818
cccagctggt tctttccgaa aaaaacggtt tatccccgct ggcgcgggga actcgccgta       60

gctgaaattg gctgcaccat gtcggccggt ttatccccgc tggcgcgggg aactcgccgt      120

agctgaaatt ggctgcacca tgtcggccgg tttatccccg ctggcgcggg gaactcggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1819
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type Cas3

<400>  1819
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1820
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 1 plasmid

<400>  1820
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccgcct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1821
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 2 plasmid

<400>  1821
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggcg     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1822
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 3 plasmid

<400>  1822
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccgccaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1823
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 4 plasmid

<400>  1823
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaacac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1824
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 5 plasmid

<400>  1824
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagaa cgagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1825
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 6 plasmid

<400>  1825
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctggagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1826
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 7 plasmid

<400>  1826
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggaagaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1827
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 8 plasmid

<400>  1827
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggataacgtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1828
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 9 plasmid

<400>  1828
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca ggcgctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1829
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 10 plasmid

<400>  1829
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc cagctgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1830
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 11 plasmid

<400>  1830
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccagcacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1831
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 12 plasmid

<400>  1831
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacaaacg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1832
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 13 plasmid

<400>  1832
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac gccaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1833
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 14 plasmid

<400>  1833
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa tgggaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1834
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 15 plasmid

<400>  1834
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcgccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1835
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 16 plasmid

<400>  1835
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc catcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1836
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 17 plasmid

<400>  1836
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatacggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1837
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 18 plasmid

<400>  1837
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcgc cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1838
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 19 plasmid

<400>  1838
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgtcaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1839
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 20 plasmid

<400>  1839
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgcccagttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1840
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 21 plasmid

<400>  1840
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg acagcagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1841
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 22 plasmid

<400>  1841
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc gcacaggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1842
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 23 plasmid

<400>  1842
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acagcggtgg     2880

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1843
<211>  8114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 24 plasmid

<400>  1843
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat ccctacttcc aatccaatcg ccaccatgcc caagaaaaag agaaaagtag      960

gatcgggcat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     1020

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     1080

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     1140

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     1200

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     1260

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     1320

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     1380

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     1440

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     1500

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     1560

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     1620

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     1680

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     1740

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     1800

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     1860

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     1920

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     1980

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     2040

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     2100

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     2160

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     2220

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     2280

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     2340

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     2400

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     2460

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     2520

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     2580

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     2640

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     2700

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     2760

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     2820

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     2880

tggagcactc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     2940

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     3000

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     3060

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     3120

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     3180

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     3240

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     3300

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     3360

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     3420

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     3480

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     3540

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     3600

gcatgaccag agtgatccca gccaacccca agtaaattgg aagtggataa tctagagggc     3660

cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac tgtgccttct     3720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcggggcatc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

gtctattctt ttgatttata agggattttg gggatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg     4440

gaaagtcccc aggctcccca ggcaggcaga agtatgcaaa gcatgcatct caattagtca     4500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     4560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     4620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     4680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     4740

ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga tcaagagaca     4800

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     4860

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     4920

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     4980

ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc cacgacgggc     5040

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     5100

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     5160

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     5220

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     5280

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     5340

aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     5400

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     5460

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     5520

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     5580

gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc gaaatgaccg     5640

accaagcgac gcccaacctg ccatcacgag atttcgattc caccgccgcc ttctatgaaa     5700

ggttgggctt cggaatcgtt ttccgggacg ccggctggat gatcctccag cgcggggatc     5760

tcatgctgga gttcttcgcc caccccaact tgtttattgc agcttataat ggttacaaat     5820

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     5880

gtttgtccaa actcatcaat gtatcttatc atgtctgtat accgtcgacc tctagctaga     5940

gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc     6000

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct     6060

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc     6120

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt     6180

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     6240

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     6300

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     6360

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     6420

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     6480

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     6540

tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     6600

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     6660

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     6720

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     6780

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     6840

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     6900

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     6960

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     7020

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     7080

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     7140

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     7200

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     7260

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     7320

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     7380

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     7440

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     7500

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     7560

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     7620

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     7680

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     7740

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     7800

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     7860

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     7920

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     7980

tcttcctttt tcattattat tgaagcattt atcagggtta ttgtctcatg agcggataca     8040

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     8100

tgccacctga cgtc                                                       8114


<210>  1844
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type Cas3

<400>  1844

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1845
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 1 plasmid

<400>  1845

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1846
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 2 plasmid

<400>  1846

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ala Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1847
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 3 plasmid

<400>  1847

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Ala Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1848
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 4 plasmid

<400>  1848

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Asn 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1849
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 5 plasmid

<400>  1849

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Asn Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1850
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 6 plasmid

<400>  1850

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Glu Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1851
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 7 plasmid

<400>  1851

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Glu Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1852
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 8 plasmid

<400>  1852

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Asn Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1853
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 9 plasmid

<400>  1853

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Ala Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1854
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 10 plasmid

<400>  1854

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Gln Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1855
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 11 plasmid

<400>  1855

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Ala Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1856
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 12 plasmid

<400>  1856

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Asn Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1857
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 13 plasmid

<400>  1857

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Ala Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1858
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 14 plasmid

<400>  1858

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Gly Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1859
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 15 plasmid

<400>  1859

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Ala Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1860
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 16 plasmid

<400>  1860

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile His Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1861
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 17 plasmid

<400>  1861

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Thr Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1862
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 18 plasmid

<400>  1862

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe Ala Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1863
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 19 plasmid

<400>  1863

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Val Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1864
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 20 plasmid

<400>  1864

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Gln Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1865
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 21 plasmid

<400>  1865

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Ser Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1866
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 22 plasmid

<400>  1866

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Ala Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1867
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 23 plasmid

<400>  1867

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Ala Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1868
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas3 mutation variant 24 plasmid

<400>  1868

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Asp Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu His 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1869
<211>  944
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thermobifida fusca-Cas3

<400>  1869

Met Pro Glu His Asp Ser Thr Asp Asp Lys His Gly Ile Pro Pro Leu 
1               5                   10                  15      


Asp Leu Arg Phe Trp Ala Lys Glu Arg Gly Leu Arg Gly Lys Thr Tyr 
            20                  25                  30          


Pro Leu Val Cys His Ser Leu Asp Ala Ala Ala Ala Ala Leu Val Leu 
        35                  40                  45              


Trp Asn Glu Tyr Leu Ser Pro Gly Leu Arg Asp Thr Ile Ala Ser Ser 
    50                  55                  60                  


Met Glu Thr Asp Glu Glu His Ala Gly His Cys Ile Ala Phe Trp Ala 
65                  70                  75                  80  


Gly Leu His Asp Ile Gly Lys Leu Thr Arg Glu Phe Gln Gln Gln Ile 
                85                  90                  95      


Ala Ile Asp Leu Ser Ala Tyr Pro Gly Glu Glu Leu Ser Gly Glu Gln 
            100                 105                 110         


Arg Ser His Ala Ala Ala Thr Gly Lys Trp Leu Pro Phe Ala Leu Pro 
        115                 120                 125             


Ser Leu Gly Tyr Pro Asn Gly Gly Leu Val Thr Gly Leu Val Ala Gln 
    130                 135                 140                 


Met Leu Gly Gly His His Gly Thr Phe His Pro His Pro Ser Phe Gln 
145                 150                 155                 160 


Ser Arg Asn Pro Leu Ala Glu Phe Gly Phe Ser Ser Pro His Trp Glu 
                165                 170                 175     


Lys Gln Arg His Ala Leu Leu His Ala Val Phe Asp Ala Thr Gly Arg 
            180                 185                 190         


Pro Thr Pro Pro Asp Met Leu Asp Gly Pro Thr Ala Ser Val Val Cys 
        195                 200                 205             


Gly Leu Val Ile Leu Ala Asp Trp Leu Val Ser Gln Glu Asp Phe Leu 
    210                 215                 220                 


Leu Glu Arg Leu Thr Ser Leu Pro Ala Asp Gly Ser Ala Ser Ala Leu 
225                 230                 235                 240 


Arg Ala His Phe Glu Thr Ser Leu Arg Arg Ile Pro Ser Leu Leu Asp 
                245                 250                 255     


Ala Ala Gly Leu Arg Pro Ile Thr Val Pro Pro Ala Thr Phe Thr Glu 
            260                 265                 270         


Ser Phe Pro His Leu Ser Lys Pro Asn Gly Leu Gln Ala Ser Leu Ala 
        275                 280                 285             


Lys His Leu Pro Cys Leu Cys Thr Gly Pro Gly Leu Val Leu Ile Thr 
    290                 295                 300                 


Ala Pro Met Gly Glu Gly Lys Thr Glu Ala Ala Tyr His Val Ala Asp 
305                 310                 315                 320 


Leu Leu Gly Lys Ala Thr Gly Arg Pro Gly Arg Phe Leu Ala Leu Pro 
                325                 330                 335     


Thr Met Ala Thr Ala Asp Gln Met His Thr Arg Leu Lys Glu Tyr Ala 
            340                 345                 350         


Arg Tyr Arg Val Glu Asn Thr Asp Leu Pro Arg Ser Ser Thr Leu Ala 
        355                 360                 365             


Leu Leu His Ser Met Ala Trp Leu Asn Pro Asp Tyr Ala Pro Ala Asp 
    370                 375                 380                 


Leu Pro Gly Val Ser Lys Val Leu Ser Asn Leu Gly His Arg Asp Pro 
385                 390                 395                 400 


Phe Ala Ala Thr Asp Trp Leu Met Gly Arg Lys Arg Gly Leu Leu Ala 
                405                 410                 415     


Pro Trp Ala Val Gly Thr Ile Asp Gln Ala Leu Met Ala Val Leu Arg 
            420                 425                 430         


Ala Lys His Asn Ala Leu Arg Leu Phe Gly Leu Ala Gly Lys Val Val 
        435                 440                 445             


Val Val Asp Glu Ala His Ala Val Asp Pro Tyr Met Gln Val Leu Leu 
    450                 455                 460                 


Glu Gln Leu Leu Arg Trp Leu Gly Thr Leu Asp Val Pro Val Val Leu 
465                 470                 475                 480 


Leu Ser Ala Thr Leu His His Ser Ile Ala Asn Ser Leu Val Lys Ala 
                485                 490                 495     


Tyr Leu Glu Gly Ala Arg Gly Arg Arg Trp Asn Arg Ser Glu Pro Gln 
            500                 505                 510         


Pro Val Ser Glu Val Ser Tyr Pro Gly Trp Leu His Val Asp Ala Arg 
        515                 520                 525             


Ile Gly Lys Val Thr Arg Ser Ser Asp Val Asp Pro Leu Pro Ile Ala 
    530                 535                 540                 


Thr Thr Pro Arg Lys Pro Leu Glu Val Arg Leu Val Asp Val Pro Val 
545                 550                 555                 560 


Lys Glu Gly Ala Leu Asn Arg Ser Thr Val Leu Ala Lys Glu Leu Thr 
                565                 570                 575     


Pro Leu Val Lys Gln Gly Gly Cys Ala Ala Ile Ile Cys Thr Thr Val 
            580                 585                 590         


Ala Glu Ala Gln Gly Val Tyr Asp Leu Leu Ser Gln Trp Phe Ala Thr 
        595                 600                 605             


Leu Gly Glu Asp Ala Pro Asp Leu Tyr Leu Leu His Ser Arg Phe Pro 
    610                 615                 620                 


Asn Arg Gln Arg Thr Glu Ile Thr Ala Thr Ile Val Asp Leu Phe Gly 
625                 630                 635                 640 


Lys Glu Gly Ala Gln Ser Gly Arg Arg Pro Thr Arg Gly Ala Val Leu 
                645                 650                 655     


Val Ala Thr Gln Val Val Glu Gln Ser Leu Asp Leu Asp Val Asp Leu 
            660                 665                 670         


Met Ile Ser Asp Leu Ala Pro Val Ser Leu Leu Leu Gln Arg Ala Gly 
        675                 680                 685             


Arg Cys Trp Arg His Glu His Leu Gly Ile Ile Asn Arg Pro Gln Trp 
    690                 695                 700                 


Ala Lys Gln Pro Glu Leu Val Val Leu Thr Pro Glu Gln Asn Gly Asp 
705                 710                 715                 720 


Ala Asp Arg Ala Pro Trp Phe Pro Arg Ser Trp Thr Ser Val Tyr Pro 
                725                 730                 735     


Leu Ala Leu Leu Gln Arg Thr Tyr Thr Leu Leu Arg Arg Arg Asn Gly 
            740                 745                 750         


Ala Pro Val Gln Ile Pro Glu Asp Val Gln Gln Leu Val Asp Asp Val 
        755                 760                 765             


Tyr Asp Asp Asp Ser Leu Ala Glu Asp Leu Glu Ala Asp Met Glu Arg 
    770                 775                 780                 


Met Gly Glu Glu Leu Ala Gln Arg Gly Leu Ala Arg Asn Ala Val Ile 
785                 790                 795                 800 


Pro Asp Pro Asp Asp Ala Glu Asp Asn Leu Asn Gly Leu Thr Glu Phe 
                805                 810                 815     


Ser Phe Asp Val Asp Glu His Val Leu Ala Thr Arg Phe Gly Ala Gly 
            820                 825                 830         


Ser Val Arg Val Leu Cys Tyr Tyr Val Asp Thr Ala Gly Asn Arg Trp 
        835                 840                 845             


Leu Asp Pro Glu Cys Thr Val Glu Phe Pro Glu Gln Gly Thr Gly Arg 
    850                 855                 860                 


Glu Gly Arg Phe Thr Met Ala Asp Cys Arg Asp Leu Val Ala Arg Thr 
865                 870                 875                 880 


Ile Pro Val Arg Met Gly Pro Trp Ala Ser Gln Leu Thr Glu Asp Asn 
                885                 890                 895     


His Pro Pro Glu Ala Trp Arg Glu Ser Phe Tyr Leu Arg Asp Leu Val 
            900                 905                 910         


Leu Ile Pro Gln Arg Val Thr Asp Glu Gly Ala Val Leu Pro Thr Glu 
        915                 920                 925             


Thr Gly Gly Arg Glu Trp Leu Leu Asp Pro Cys Lys Gly Leu Ile Phe 
    930                 935                 940                 


<210>  1870
<211>  919
<212>  PRT
<213>  Saccharomonospora viridis

<400>  1870

Met Leu Leu Val Asp Leu Arg Phe Trp Gly Lys Glu Arg Gly Leu Glu 
1               5                   10                  15      


Gly Ala Arg Tyr Pro Leu Val Cys His Gly Leu Asp Ala Ala Ala Ala 
            20                  25                  30          


Val Arg Trp Leu Trp Lys Arg Tyr Leu Ser Ala Arg Val Arg Ala Gly 
        35                  40                  45              


Leu Ala Glu Ala Val Gly Leu Thr Glu Glu Gln Thr Cys Arg Val Leu 
    50                  55                  60                  


Glu Phe Trp Ala Ala Ala His Asp Val Gly Lys Leu Thr Pro Gly Phe 
65                  70                  75                  80  


Gln Glu Gln Val Gly Val Pro Glu Gly Tyr Leu Pro Asp Ser Thr Gly 
                85                  90                  95      


Arg Arg Cys Arg His Glu Glu Ala Ser His Ile Trp Leu Pro Ser Ala 
            100                 105                 110         


Leu Thr Ala Val Glu His Thr Thr Asn Ser Arg Asn Ala Arg Leu Ile 
        115                 120                 125             


Ala Gln Met Leu Gly Gly His His Gly Val Phe Arg Arg Arg Asp Ser 
    130                 135                 140                 


Ala Asp Phe Arg Pro Gly Met Phe Val His Leu Gly Leu Gly Asp Ser 
145                 150                 155                 160 


Ser Trp Asp Leu Gln Arg His Ala His Leu Gln Ala Trp Arg Ala Leu 
                165                 170                 175     


Leu Glu Pro Pro Thr Leu Pro Arg Arg Leu Ser Arg His Ala Ala Ala 
            180                 185                 190         


Val Ala Thr Gly Val Val Ile Leu Ala Asp Trp Leu Val Ser Gln Ile 
        195                 200                 205             


Asp Tyr Val Arg Ser Arg Leu Pro Ser Leu Pro Glu Gln Gly Asp Leu 
    210                 215                 220                 


Pro Ser Leu Ser Glu Phe Leu Ser Gly Ser Arg Glu Ala Thr Glu Ser 
225                 230                 235                 240 


Val Val Arg Gln Ala Gly Leu Ser Arg Leu Arg Leu Arg Gly Gly Thr 
                245                 250                 255     


Phe Glu Glu Glu Phe Gly Phe Asp Glu Pro Asn Glu Leu Gln Ser Ser 
            260                 265                 270         


Ile Ala Ala Glu Leu Pro Gly Leu Leu Gly Asn Pro Gly Leu Leu Met 
        275                 280                 285             


Ile Ala Ala Pro Thr Gly Phe Gly Lys Thr Glu Ala Ala Leu His Ala 
    290                 295                 300                 


Ala Arg Leu Leu Ser Asp Ala Ala Gly Thr Ser Gly Met Phe Phe Ala 
305                 310                 315                 320 


Leu Pro Thr Met Ala Thr Ser Asp Glu Met Phe Asn Arg Ile Ala Arg 
                325                 330                 335     


Tyr Val Val Arg Arg Ala Glu Thr Gly Val Ala Gln Ser Leu Leu His 
            340                 345                 350         


Gly Met Ala Trp Leu Lys Pro Leu Arg Glu Thr Leu Glu Gln Ile His 
        355                 360                 365             


Ala Glu Glu Gly Leu Ser Ser Asp Asp Glu Thr Gln Val His Gly Leu 
    370                 375                 380                 


Glu Trp Leu Gln Gly Leu Lys Arg Ala Met Leu Ala Pro Val Gly Val 
385                 390                 395                 400 


Gly Thr Ile Asp Gln Ala Leu Leu Ala Val Leu Pro Val Arg His Asn 
                405                 410                 415     


Ala Leu Arg Leu Phe Ser Leu Leu Gly Lys Thr Val Val Ile Asp Glu 
            420                 425                 430         


Val His Ala Phe Ser Pro Tyr Met Arg Arg Leu Leu Cys Thr Leu Leu 
        435                 440                 445             


Gly Trp Leu Gly Glu Trp Asn Val Pro Val Val Leu Leu Ser Ala Thr 
    450                 455                 460                 


Leu Pro Arg Asn Ile Ala Ala Glu Leu Ala Ala Ala Tyr Arg Gly Gln 
465                 470                 475                 480 


Asn Thr Gly Thr Pro Pro Asp Val Pro Val Pro Tyr Pro Gly Trp Thr 
                485                 490                 495     


Tyr Ile Glu Arg Glu Ser Gly Ile Lys Thr Arg Ser Val Asp Phe Pro 
            500                 505                 510         


Arg Ser His Arg Arg Thr Leu Ser Val Gln Leu Arg Pro Val Ala Val 
        515                 520                 525             


Ala Arg Glu Ser Gly Pro Asp Arg Leu Pro Val Leu Arg Glu Val Leu 
    530                 535                 540                 


Ala Pro Ile Val Val Asp Glu Gly Gly Gly Cys Ala Leu Val Leu Cys 
545                 550                 555                 560 


Thr Thr Val Ala Glu Ala Gln Gln Thr Tyr Arg Ala Leu Arg Asp Trp 
                565                 570                 575     


Leu Gly Glu Thr Asp Val Asp Leu Arg Leu Leu His Ala Arg Tyr Pro 
            580                 585                 590         


Met His Arg Arg Glu Thr Leu Thr Ala Glu Leu Met Arg Ala Phe Gly 
        595                 600                 605             


Lys Pro Gln His Gly Asp Gly Gly Ala Ser His Val Gly Asn Arg Pro 
    610                 615                 620                 


Ala Lys Ala Val Val Val Ala Thr Gln Val Val Glu Gln Ser Leu Asp 
625                 630                 635                 640 


Leu Asp Phe Asp Leu Val Val Ser Asp Leu Ala Pro Ile Glu Leu Leu 
                645                 650                 655     


Leu Gln Arg Ala Gly Arg Leu Gln Arg His Ser Gly Trp Asp Pro His 
            660                 665                 670         


Arg Pro Ala Trp Ala Asp Val Ser Arg Gly Gly Gln Arg Arg Phe Ile 
        675                 680                 685             


Val Leu Thr Ala Pro Asp Gly Asp Leu His Arg Leu Pro Arg Ser Trp 
    690                 695                 700                 


Lys Phe Ile Tyr Pro Pro Ile Ser Leu Ile Arg Ala His Arg Leu Leu 
705                 710                 715                 720 


Ala Glu Arg Ala Ala Arg Gly Val Arg Ile Pro Asp Asp Val Gln Glu 
                725                 730                 735     


Leu Val Asp Arg Gly Asn Pro Gly Gln Phe Pro Asp Leu Asp Asp Pro 
            740                 745                 750         


Ser Val Ser Gly Phe Thr Glu Glu Glu Ile Arg Arg Ser Ala Glu Ser 
        755                 760                 765             


Leu Val Glu Thr Gly Thr Ala Asp Ser Ala Ser Ile Pro Val Pro Lys 
    770                 775                 780                 


Ala Leu Thr Asn Leu Thr Asp Leu Ser Lys Gly Pro Leu Glu Glu Glu 
785                 790                 795                 800 


Gln Val Thr Thr Arg Phe Asn Ala Asp Ser His Arg Ala Leu Pro Val 
                805                 810                 815     


Phe Arg Thr His Asp Gly Ala Leu Arg Leu Gly Gly Ala His Gly Glu 
            820                 825                 830         


Pro Leu Pro Val Pro Arg Glu Gly Lys Leu Ser Lys Asp Glu Leu Lys 
        835                 840                 845             


Ser Ile Met Lys His Thr Val Pro Val Pro Gly Ser Val Val Arg Gly 
    850                 855                 860                 


Lys Asp Glu Arg His Gln Leu Pro Glu Pro Trp Arg Glu Ile Thr Val 
865                 870                 875                 880 


Leu Arg Asp Leu Val Val Leu Pro His His Ile Asp Glu Asp Gly Thr 
                885                 890                 895     


Val His Pro Ala Ser Val Gly Gly Arg Lys Leu Leu Leu Asp Asp Val 
            900                 905                 910         


Leu Gly Leu Leu Ala Val Glu 
        915                 


<210>  1871
<211>  10300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade polycistronic plasmid

<400>  1871
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cccaagaaaa agagaaaagt aggatcgggc gaacagaaac      960

ttatatctga ggaggacctc ggatcgggca tgtcaaattt tattaatatt catgttctga     1020

tcagtcatag cccgagttgc ctgaatagag acgacatgaa tatgcagaaa gacgcaattt     1080

tcggtggcaa gaggcgagtc cgaataagca gccaaagtct taagcgagcc atgaggaaga     1140

gcggctatta tgcccagaat atcggcgagt cctcattgcg gaccatccac ctcgcccagt     1200

tgagagacgt cttgaggcag aaactggggg aaagattcga ccagaaaatc attgacaaga     1260

cccttgccct ccttagtggg aagagcgtgg acgaggctga aaaaatctct gccgacgccg     1320

taacgccctg ggttgtgggt gagattgctt ggttttgtga acaggtggcg aaggcggagg     1380

ccgataacct ggatgacaag aagctgctga aggtccttaa ggaggacata gctgccattc     1440

gggtcaattt gcagcaggga gtggatatcg cattgtccgg aagaatggct acatcaggca     1500

tgatgaccga gctgggcaag gtagacggag ccatgagtat cgcacacgcc atcaccaccc     1560

accaagtcga ctcagacatc gactggttca cagcagtaga tgacctccag gagcaggggt     1620

ctgcccacct tgggacacag gagttctctt ccggggtgtt ttatcgctat gctaatatca     1680

atctggcgca gctgcaagaa aacctggggg gagcctctcg agagcaggcc ctggagattg     1740

caactcacgt cgtgcatatg cttgcgacag aggtacctgg cgccaagcag aggacatacg     1800

ctgcttttaa tccagcagat atggtcatgg taaatttctc tgatatgcct ctctccatgg     1860

ccaacgcatt cgagaaggca gtgaaggcaa aggacgggtt cctgcagcca tcaattcaag     1920

cgtttaatca gtattgggac agagtggcga acggctatgg actgaacgga gccgcagctc     1980

agtttagcct cagcgatgtc gatcccataa ctgcacaggt gaaacagatg cctacgttgg     2040

aacagctgaa gtcatgggta agaaataacg gcgaagccgg cagcggcgag ggcagaggca     2100

gcctgctgac ctgcggcgac gtggaggaga accccggccc ccccaagaaa aagagaaaag     2160

taggatcggg cgattacaaa gatcacgatg gggactacaa ggatcacgat attgactata     2220

aggacgacga tgacaaggga tcgggcatgg ccgacgagat tgacgcaatg gcactttacc     2280

gggcctggca gcagttggat aatggttcat gtgcccagat tcgcagagtt agtgaacctg     2340

acgaactgag agatatcccc gcgttttaca gacttgtcca accgttcgga tgggagaacc     2400

cacggcacca acaagcactc cttcgaatgg tcttctgttt gtccgcagga aaaaatgtaa     2460

tcagacacca agacaaaaag agcgagcaaa ccacaggtat cagcctgggc agggcacttg     2520

ccaactctgg gcggatcaac gaaaggagaa tttttcagct gatacgcgct gatcggactg     2580

cggacatggt gcagctgcgc agactcctta ctcatgccga acctgtcctg gattggcccc     2640

tgatggcacg catgctgact tggtggggaa agagagaaag acagcaactg cttgaagact     2700

tcgtgctcac tacaaataag aatgccggat ccggagaagg aaggggatcc ctcctcacat     2760

gtggagatgt cgaagaaaat cctggacctc ccaagaaaaa gagaaaagta ggatcgggca     2820

tgcggagcta tctcatcctg agactggccg gaccaatgca ggcctgggga cagcctacct     2880

tcgaaggtac acgccccaca ggccgctttc ctaccaggag cggcctgctg ggcctgcttg     2940

gcgcttgtct tgggatccag cgcgatgata ctagctccct gcaagcactg tcagagagcg     3000

tgcagtttgc cgtaagatgc gacgaactga tccttgatga taggcgggtc agtgtcactg     3060

gtctccggga ctaccacacg gtgctggggg cccgggagga ttataggggc ctgaaaagtc     3120

acgagacgat tcaaacctgg cgcgaatatc tgtgcgatgc cagcttcacc gtggccctgt     3180

ggctgactcc acatgccact atggtcatca gtgaactgga aaaggctgtt cttaagcctc     3240

gatatactcc gtatctgggc cgccggagtt gtccacttac acacccactt ttcctcggca     3300

cctgccaggc cagcgaccct caaaaggccc ttctgaatta cgagccagtt ggcggtgaca     3360

tatacagcga agagtccgtg acgggacacc atcttaagtt caccgctcgg gacgagccca     3420

tgattaccct cccacggcag ttcgcatcaa gggagtggta cgtcataaag gggggcatgg     3480

atgtgagtca ggggtctggg gaggggcggg ggtctttgtt gacttgcggg gatgttgagg     3540

agaacccagg gccacccaag aaaaagagaa aagtaggctc aggcggtaaa cccatcccaa     3600

accccttgct tggtctcgac tcaaccggat cgggcatgta tctgtcaaag gttatcattg     3660

cacgcgcgtg gagtagggat ctgtatcagc tgcaccaggg tctgtggcat cttttcccga     3720

accgccccga cgcggcacga gactttctgt ttcacgttga aaaaagaaac acccccgagg     3780

gctgtcatgt gctcctgcag tctgcccaga tgccggtgag cacagctgtg gcgactgtga     3840

tcaagaccaa gcaggtcgag tttcagctcc aggtaggggt tccactgtat tttcgcctga     3900

gagctaatcc gatcaaaacc atactggata atcagaagag gctcgacagc aaaggaaata     3960

ttaaaaggtg ccgggtcccg ctcatcaaag aggctgagca aatcgcttgg cttcaacgga     4020

aactggggaa cgcagcccgc gtggaagacg tccacccgat tagtgaacgg ccccaatatt     4080

tttccggaga cggaaagagc ggcaagattc agacagtctg tttcgagggg gtgctcacca     4140

tcaatgatgc ccccgccctg atagacctgg tgcagcaggg cataggcccc gctaaaagca     4200

tgggatgcgg actgcttagt ctggcaccgc tgggatccgg agagggcaga ggaagtctgc     4260

taacatgcgg tgacgtcgag gagaatcctg gacctcccaa gaaaaagaga aaagtaggat     4320

cgggcatgaa tttgctcatt gataattgga ttccggtgcg cccccggaac ggtgggaaag     4380

tgcagatcat caatttgcaa agtctctact gttccaggga ccagtggaga ctcagcctgc     4440

cacgggatga tatggagctg gcggcgttgg ctctgctcgt atgcatcggc cagattattg     4500

cgccagcaaa ggatgacgtt gaattccggc atcggataat gaaccccctt actgaagatg     4560

agttccagca gcttatcgcc ccatggatcg acatgttcta cctcaaccac gccgagcatc     4620

cttttatgca gaccaaggga gtcaaggcga atgatgtgac tcccatggag aagctgctgg     4680

ccggtgtatc tggggcgacc aactgcgcat tcgtgaatca gcctggacag ggggaggccc     4740

tctgtggagg ctgcactgct atagcacttt ttaaccaagc taatcaagcc cccggctttg     4800

gtggagggtt taagagtgga ttgagggggg gcactcccgt aaccactttt gtgaggggaa     4860

ttgatctgag gtctactgtg ttgctgaacg tcctcacact cccaaggctc cagaagcagt     4920

tcccaaacga aagtcatacc gaaaaccagc ccacatggat caagcccatc aaatctaatg     4980

agagcatacc ggctagcagt attggatttg tacggggtct gttctggcag ccagctcaca     5040

tcgagctgtg tgatcctatt gggatcggca agtgctcttg ttgtgggcag gagtccaacc     5100

ttaggtatac tggatttctg aaagagaagt ttacctttac agtaaatggg ctctggcccc     5160

acccccactc accttgcctt gtgacagtga aaaaggggga agtcgaggag aagtttctgg     5220

cctttacaac ttctgcccct tcctggactc agatttccag agtggtggta gataagataa     5280

ttcaaaacga gaatggcaat agagtggccg ccgtggtgaa ccagtttcgc aacatcgccc     5340

ctcagtcccc cctggagctg attatgggcg gttatcggaa taaccaggcc agtatactcg     5400

agcgacggca cgatgtcctc atgttcaatc aaggttggca gcaatatggc aatgtgatta     5460

acgagatcgt aaccgtgggc ctgggatata agaccgccct gcggaaggcg ttgtatactt     5520

ttgcagaagg ctttaagaat aaggatttta agggtgccgg cgtgagtgtc catgaaacag     5580

ctgaacggca cttttatcgg cagtccgagc tgttgatacc agacgtgctg gctaatgtga     5640

acttctcaca ggccgacgaa gtgatcgctg atctgcggga taaactgcac caactgtgcg     5700

agatgctgtt taatcaaagc gtcgctcctt atgcccacca cccaaagctg atctccacgc     5760

tggccctggc gcgcgccaca ctttataaac atctccgcga actgaaaccc caggggggcc     5820

ccagcaatgg ctaataatct agagggccct attctatagt gtcacctaaa tgctagagct     5880

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     5940

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     6000

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     6060

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     6120

gcttctgagg cggaaagaac cagctggggc tctagggggt atccccacgc gccctgtagc     6180

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     6240

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     6300

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     6360

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag     6420

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     6480

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg     6540

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattaattc     6600

tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta     6660

tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag     6720

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa     6780

ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc catggctgac     6840

taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta ttccagaagt     6900

agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga gcttgtatat     6960

ccattttcgg atctgatcaa gagacaggat gaggatcgtt tcgcatgatt gaacaagatg     7020

gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac     7080

aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg     7140

ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac gaggcagcgc     7200

ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg     7260

aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc     7320

accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc     7380

ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta     7440

ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg     7500

cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag gatctcgtcg     7560

tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat     7620

tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc     7680

gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta     7740

tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgag     7800

cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat cacgagattt     7860

cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc gggacgccgg     7920

ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc ccaacttgtt     7980

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     8040

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     8100

ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc tgtttcctgt     8160

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     8220

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     8280

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     8340

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     8400

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     8460

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     8520

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     8580

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     8640

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     8700

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     8760

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     8820

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     8880

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     8940

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     9000

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     9060

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     9120

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     9180

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     9240

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     9300

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     9360

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     9420

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     9480

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     9540

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     9600

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     9660

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     9720

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     9780

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     9840

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     9900

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     9960

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag    10020

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac    10080

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc    10140

gacacggaaa tgttgaatac tcatactctt cctttttcat tattattgaa gcatttatca    10200

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg    10260

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc                          10300


<210>  1872
<211>  1638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade polycistronic plasmid

<400>  1872

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Glu Gln Lys Leu Ile 
1               5                   10                  15      


Ser Glu Glu Asp Leu Gly Ser Gly Met Ser Asn Phe Ile Asn Ile His 
            20                  25                  30          


Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp Asp Met Asn 
        35                  40                  45              


Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val Arg Ile Ser 
    50                  55                  60                  


Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr Tyr Ala Gln 
65                  70                  75                  80  


Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala Gln Leu Arg 
                85                  90                  95      


Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln Lys Ile Ile 
            100                 105                 110         


Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp Glu Ala Glu 
        115                 120                 125             


Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly Glu Ile Ala 
    130                 135                 140                 


Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn Leu Asp Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala Ile Arg Val 
                165                 170                 175     


Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg Met Ala Thr 
            180                 185                 190         


Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala Met Ser Ile 
        195                 200                 205             


Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile Asp Trp Phe 
    210                 215                 220                 


Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His Leu Gly Thr 
225                 230                 235                 240 


Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn Ile Asn Leu 
                245                 250                 255     


Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu Gln Ala Leu 
            260                 265                 270         


Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu Val Pro Gly 
        275                 280                 285             


Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp Met Val Met 
    290                 295                 300                 


Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala Phe Glu Lys 
305                 310                 315                 320 


Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile Gln Ala Phe 
                325                 330                 335     


Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu Asn Gly Ala 
            340                 345                 350         


Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr Ala Gln Val 
        355                 360                 365             


Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val Arg Asn Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
385                 390                 395                 400 


Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val Gly 
                405                 410                 415     


Ser Gly Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
            420                 425                 430         


Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gly Met Ala Asp Glu Ile 
        435                 440                 445             


Asp Ala Met Ala Leu Tyr Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser 
    450                 455                 460                 


Cys Ala Gln Ile Arg Arg Val Ser Glu Pro Asp Glu Leu Arg Asp Ile 
465                 470                 475                 480 


Pro Ala Phe Tyr Arg Leu Val Gln Pro Phe Gly Trp Glu Asn Pro Arg 
                485                 490                 495     


His Gln Gln Ala Leu Leu Arg Met Val Phe Cys Leu Ser Ala Gly Lys 
            500                 505                 510         


Asn Val Ile Arg His Gln Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile 
        515                 520                 525             


Ser Leu Gly Arg Ala Leu Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg 
    530                 535                 540                 


Ile Phe Gln Leu Ile Arg Ala Asp Arg Thr Ala Asp Met Val Gln Leu 
545                 550                 555                 560 


Arg Arg Leu Leu Thr His Ala Glu Pro Val Leu Asp Trp Pro Leu Met 
                565                 570                 575     


Ala Arg Met Leu Thr Trp Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu 
            580                 585                 590         


Glu Asp Phe Val Leu Thr Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly 
        595                 600                 605             


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
    610                 615                 620                 


Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Arg Ser Tyr Leu Ile 
625                 630                 635                 640 


Leu Arg Leu Ala Gly Pro Met Gln Ala Trp Gly Gln Pro Thr Phe Glu 
                645                 650                 655     


Gly Thr Arg Pro Thr Gly Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly 
            660                 665                 670         


Leu Leu Gly Ala Cys Leu Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu 
        675                 680                 685             


Gln Ala Leu Ser Glu Ser Val Gln Phe Ala Val Arg Cys Asp Glu Leu 
    690                 695                 700                 


Ile Leu Asp Asp Arg Arg Val Ser Val Thr Gly Leu Arg Asp Tyr His 
705                 710                 715                 720 


Thr Val Leu Gly Ala Arg Glu Asp Tyr Arg Gly Leu Lys Ser His Glu 
                725                 730                 735     


Thr Ile Gln Thr Trp Arg Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val 
            740                 745                 750         


Ala Leu Trp Leu Thr Pro His Ala Thr Met Val Ile Ser Glu Leu Glu 
        755                 760                 765             


Lys Ala Val Leu Lys Pro Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser 
    770                 775                 780                 


Cys Pro Leu Thr His Pro Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp 
785                 790                 795                 800 


Pro Gln Lys Ala Leu Leu Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr 
                805                 810                 815     


Ser Glu Glu Ser Val Thr Gly His His Leu Lys Phe Thr Ala Arg Asp 
            820                 825                 830         


Glu Pro Met Ile Thr Leu Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr 
        835                 840                 845             


Val Ile Lys Gly Gly Met Asp Val Ser Gln Gly Ser Gly Glu Gly Arg 
    850                 855                 860                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro 
865                 870                 875                 880 


Lys Lys Lys Arg Lys Val Gly Ser Gly Gly Lys Pro Ile Pro Asn Pro 
                885                 890                 895     


Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly Met Tyr Leu Ser Lys Val 
            900                 905                 910         


Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu Tyr Gln Leu His Gln Gly 
        915                 920                 925             


Leu Trp His Leu Phe Pro Asn Arg Pro Asp Ala Ala Arg Asp Phe Leu 
    930                 935                 940                 


Phe His Val Glu Lys Arg Asn Thr Pro Glu Gly Cys His Val Leu Leu 
945                 950                 955                 960 


Gln Ser Ala Gln Met Pro Val Ser Thr Ala Val Ala Thr Val Ile Lys 
                965                 970                 975     


Thr Lys Gln Val Glu Phe Gln Leu Gln Val Gly Val Pro Leu Tyr Phe 
            980                 985                 990         


Arg Leu Arg Ala Asn Pro Ile Lys  Thr Ile Leu Asp Asn  Gln Lys Arg 
        995                 1000                 1005             


Leu Asp  Ser Lys Gly Asn Ile  Lys Arg Cys Arg Val  Pro Leu Ile 
    1010                 1015                 1020             


Lys Glu  Ala Glu Gln Ile Ala  Trp Leu Gln Arg Lys  Leu Gly Asn 
    1025                 1030                 1035             


Ala Ala  Arg Val Glu Asp Val  His Pro Ile Ser Glu  Arg Pro Gln 
    1040                 1045                 1050             


Tyr Phe  Ser Gly Asp Gly Lys  Ser Gly Lys Ile Gln  Thr Val Cys 
    1055                 1060                 1065             


Phe Glu  Gly Val Leu Thr Ile  Asn Asp Ala Pro Ala  Leu Ile Asp 
    1070                 1075                 1080             


Leu Val  Gln Gln Gly Ile Gly  Pro Ala Lys Ser Met  Gly Cys Gly 
    1085                 1090                 1095             


Leu Leu  Ser Leu Ala Pro Leu  Gly Ser Gly Glu Gly  Arg Gly Ser 
    1100                 1105                 1110             


Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn Pro Gly  Pro Pro Lys 
    1115                 1120                 1125             


Lys Lys  Arg Lys Val Gly Ser  Gly Met Asn Leu Leu  Ile Asp Asn 
    1130                 1135                 1140             


Trp Ile  Pro Val Arg Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile 
    1145                 1150                 1155             


Asn Leu  Gln Ser Leu Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser 
    1160                 1165                 1170             


Leu Pro  Arg Asp Asp Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val 
    1175                 1180                 1185             


Cys Ile  Gly Gln Ile Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe 
    1190                 1195                 1200             


Arg His  Arg Ile Met Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln 
    1205                 1210                 1215             


Leu Ile  Ala Pro Trp Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu 
    1220                 1225                 1230             


His Pro  Phe Met Gln Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr 
    1235                 1240                 1245             


Pro Met  Glu Lys Leu Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys 
    1250                 1255                 1260             


Ala Phe  Val Asn Gln Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly 
    1265                 1270                 1275             


Cys Thr  Ala Ile Ala Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly 
    1280                 1285                 1290             


Phe Gly  Gly Gly Phe Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val 
    1295                 1300                 1305             


Thr Thr  Phe Val Arg Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu 
    1310                 1315                 1320             


Asn Val  Leu Thr Leu Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu 
    1325                 1330                 1335             


Ser His  Thr Glu Asn Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser 
    1340                 1345                 1350             


Asn Glu  Ser Ile Pro Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu 
    1355                 1360                 1365             


Phe Trp  Gln Pro Ala His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile 
    1370                 1375                 1380             


Gly Lys  Cys Ser Cys Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr 
    1385                 1390                 1395             


Gly Phe  Leu Lys Glu Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp 
    1400                 1405                 1410             


Pro His  Pro His Ser Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu 
    1415                 1420                 1425             


Val Glu  Glu Lys Phe Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp 
    1430                 1435                 1440             


Thr Gln  Ile Ser Arg Val Val  Val Asp Lys Ile Ile  Gln Asn Glu 
    1445                 1450                 1455             


Asn Gly  Asn Arg Val Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile 
    1460                 1465                 1470             


Ala Pro  Gln Ser Pro Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn 
    1475                 1480                 1485             


Asn Gln  Ala Ser Ile Leu Glu  Arg Arg His Asp Val  Leu Met Phe 
    1490                 1495                 1500             


Asn Gln  Gly Trp Gln Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val 
    1505                 1510                 1515             


Thr Val  Gly Leu Gly Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr 
    1520                 1525                 1530             


Thr Phe  Ala Glu Gly Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly 
    1535                 1540                 1545             


Val Ser  Val His Glu Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser 
    1550                 1555                 1560             


Glu Leu  Leu Ile Pro Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln 
    1565                 1570                 1575             


Ala Asp  Glu Val Ile Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu 
    1580                 1585                 1590             


Cys Glu  Met Leu Phe Asn Gln  Ser Val Ala Pro Tyr  Ala His His 
    1595                 1600                 1605             


Pro Lys  Leu Ile Ser Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr 
    1610                 1615                 1620             


Lys His  Leu Arg Glu Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    1625                 1630                 1635             


<210>  1873
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target specific primer

<400>  1873
cactctttcc ctacacgacg ctcttccgat ctctcttcca accacactgc ag               52


<210>  1874
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Target specific primer

<400>  1874
ggagttcaga cgtgtgctct tccgatctgg tttccaggtt gccgtttt                    48


<210>  1875
<211>  12850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas3-17aa-Cas8 fusion

<400>  1875
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcagggg tctggggagg ggcgggggtc tttgttgact tgcggggatg     3420

ttgaggagaa tcctggacct cccaaaaaaa aacggaaggt gggctcaggc atgtatctgt     3480

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     3540

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     3600

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     3660

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     3720

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     3780

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     3840

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     3900

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     3960

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     4020

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctggga tccggagagg     4080

gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggacct cccaagaaaa     4140

agagaaaagt aggatcgggc atggagccct tcaagtacat ctgccactat tggggcaaga     4200

gctccaagag cctgacaaag ggcaacgaca tccacctgct gatctaccac tgcctggacg     4260

tggcagcagt ggcagattgt tggtgggacc agtctgtggt gctgcagaat accttttgtc     4320

ggaacgagat gctgagcaag cagagagtga aggcctggct gctgttcttt atcgccctgc     4380

acgacatcgg caagttcgac atcaggtttc agtataagtc cgccgagtct tggctgaagc     4440

tgaatccagc cacacccagc ctgaacggcc cttccaccca gatgtgcagg aagttcaatc     4500

acggcgcagc aggactgtac tggtttaacc aggactctct gagcgagcag tccctgggcg     4560

atttcttttc tttctttgac gcagcacctc acccctacga gagctggttc ccttgggtgg     4620

aggcagtgac aggacaccac ggctttatcc tgcacagcca ggaccaggat aagtccaggt     4680

gggagatgcc agccagcctg gcctcctacg ccgcacagga taagcaggcc cgcgaggagt     4740

ggatctccgt gctggaggcc ctgttcctga ccccagcagg actgtctatc aatgacatcc     4800

cccctgactg ctctagcctg ctggccggct tttgttctct ggccgactgg ctgggcagct     4860

ggaccacaac caatacattc ctgtttaacg aggatgcacc atccgacatc aacgcactgc     4920

gcacctactt ccaggatagg cagcaggacg ccagccgggt gctggagctg tccggcctgg     4980

tgtctaataa gcggtgctac gagggagtgc acgcactgct ggataacggc tatcagccca     5040

gacagctgca ggtgctggtg gacgcactgc ctgtggcacc aggactgaca gtgatcgagg     5100

cacctaccgg ctccggcaag acagagaccg ccctggccta tgcctggaag ctgatcgatc     5160

agcagatcgc cgactctgtg atcttcgccc tgccaacaca ggccaccgcc aatgccatgc     5220

tgaccaggat ggaggcctcc gcctctcacc tgttttcctc tcccaacctg atcctggccc     5280

acggcaacag ccggttcaat cacctgtttc agtctatcaa gagcagagcc atcacagagc     5340

agggacagga ggaggcctgg gtgcagtgct gtcagtggct gagccagtcc aataagaagg     5400

tgttcctggg ccagatcggc gtgtgcacca tcgatcaggt gctgatcagc gtgctgcctg     5460

tgaagcacag gtttatcagg ggactgggaa tcggccgctc cgtgctgatc gtggatgagg     5520

tgcacgccta cgacacatat atgaacggcc tgctggaggc cgtgctgaag gcacaggcag     5580

acgtgggcgg ctctgtgatc ctgctgagcg ccaccctgcc aatgaagcag aagcagaagc     5640

tgctggatac atacggcctg cacaccgacc ccgtggagaa caattctgcc tatcctctga     5700

tcaattggag gggagtgaac ggagcacagc ggttcgacct gctggcccac cctgagcagc     5760

tgccaccacg gttttccatc cagcccgagc ctatctgcct ggccgatatg ctgccagacc     5820

tgaccatgct ggagagaatg atcgctgccg ccaatgcagg agcacaggtg tgcctgatct     5880

gtaacctggt ggatgtggcc caggtgtgct accagcggct gaaggagctg aacaatacac     5940

aggtggacat cgatctgttc cacgccaggt ttaccctgaa tgaccggaga gagaaggaga     6000

accgcgtgat cagcaacttc ggcaagaatg gcaagagaaa cgtgggcaga atcctggtgg     6060

ccacacaggt ggtggagcag tccctggacg tggatttcga ctggctgatc acccagcact     6120

gccccgccga tctgctgttt cagcggctgg gcagactgca caggcaccac cgcaagtata     6180

ggcctgcagg attcgagatc ccagtggcaa caatcctgct gcctgacgga gagggatacg     6240

gccggcacga gcacatctat agcaatgtgc gcgtgatgtg gcggacccag cagcacatcg     6300

aggagctgaa cggcgccagc ctgttctttc cagatgccta cagacagtgg ctggactcca     6360

tctatgacga tgccgagatg gatgagcccg agtgggtggg caatggcatg gacaagttcg     6420

agtccgccga gtgtgagaag cggttcaagg ccaggaaggt gctgcagtgg gccgaggagt     6480

actctctgca ggataacgac gagacaatcc tggccgtgac ccgggacgga gagatgagcc     6540

tgccactgct gccttatgtg cagacaagct ccggcaagca gctgctggat ggccaggtgt     6600

acgaggacct gagccacgag cagcagtatg aggccctggc cctgaacagg gtgaatgtgc     6660

ccttcacctg gaagcggagc ttcagcgaag tggtggatga ggacggcctg ctgtggctgg     6720

agggcaagca gaatctggat ggctgggtgt ggcagggcaa ctccatcgtg atcacataca     6780

ccggcgacga gggcatgacc agagtgatcc cagccaaccc caaggctgac ccaactaaca     6840

gagctaaggg cctggaggcc gtatctgtgg catcaatgaa tttgctcatt gataattgga     6900

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     6960

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     7020

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     7080

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     7140

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     7200

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     7260

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     7320

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     7380

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     7440

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     7500

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     7560

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     7620

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     7680

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     7740

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     7800

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     7860

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     7920

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     7980

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     8040

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     8100

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     8160

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     8220

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     8280

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     8340

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     8400

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     8460

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     8520

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     8580

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     8640

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     8700

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     8760

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     8820

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     8880

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     8940

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     9000

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     9060

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     9120

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     9180

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     9240

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     9300

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     9360

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     9420

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     9480

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     9540

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     9600

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     9660

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     9720

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     9780

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     9840

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     9900

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     9960

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg    10020

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg    10080

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata    10140

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg    10200

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat    10260

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct    10320

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca    10380

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt    10440

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat    10500

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag    10560

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt    10620

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt    10680

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca    10740

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact    10800

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct    10860

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc    10920

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca    10980

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg    11040

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca    11100

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa    11160

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc    11220

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc    11280

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct    11340

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg    11400

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag    11460

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta    11520

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg    11580

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt    11640

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt    11700

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag    11760

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat    11820

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc    11880

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat    11940

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc    12000

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag    12060

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag    12120

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt    12180

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg    12240

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt    12300

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc    12360

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc    12420

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa    12480

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg    12540

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc    12600

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag    12660

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt    12720

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt    12780

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc    12840

acctgacgtc                                                           12850


<210>  1876
<211>  12847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas8-17aa-Cas3 fusion

<400>  1876
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcagggg tctggggagg ggcgggggtc tttgttgact tgcggggatg     3420

ttgaggagaa tcctggacct cccaaaaaaa aacggaaggt gggctcaggc atgtatctgt     3480

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     3540

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     3600

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     3660

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     3720

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     3780

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     3840

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     3900

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     3960

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     4020

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctggga tccggagagg     4080

gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggacct cccaagaaaa     4140

agagaaaagt aggatcgggc aatttgctca ttgataattg gattccggtg cgcccccgga     4200

acggtgggaa agtgcagatc atcaatttgc aaagtctcta ctgttccagg gaccagtgga     4260

gactcagcct gccacgggat gatatggagc tggcggcgtt ggctctgctc gtatgcatcg     4320

gccagattat tgcgccagca aaggatgacg ttgaattccg gcatcggata atgaaccccc     4380

ttactgaaga tgagttccag cagcttatcg ccccatggat cgacatgttc tacctcaacc     4440

acgccgagca tccttttatg cagaccaagg gagtcaaggc gaatgatgtg actcccatgg     4500

agaagctgct ggccggtgta tctggggcga ccaactgcgc attcgtgaat cagcctggac     4560

agggggaggc cctctgtgga ggctgcactg ctatagcact ttttaaccaa gctaatcaag     4620

cccccggctt tggtggaggg tttaagagtg gattgagggg gggcactccc gtaaccactt     4680

ttgtgagggg aattgatctg aggtctactg tgttgctgaa cgtcctcaca ctcccaaggc     4740

tccagaagca gttcccaaac gaaagtcata ccgaaaacca gcccacatgg atcaagccca     4800

tcaaatctaa tgagagcata ccggctagca gtattggatt tgtacggggt ctgttctggc     4860

agccagctca catcgagctg tgtgatccta ttgggatcgg caagtgctct tgttgtgggc     4920

aggagtccaa ccttaggtat actggatttc tgaaagagaa gtttaccttt acagtaaatg     4980

ggctctggcc ccacccccac tcaccttgcc ttgtgacagt gaaaaagggg gaagtcgagg     5040

agaagtttct ggcctttaca acttctgccc cttcctggac tcagatttcc agagtggtgg     5100

tagataagat aattcaaaac gagaatggca atagagtggc cgccgtggtg aaccagtttc     5160

gcaacatcgc ccctcagtcc cccctggagc tgattatggg cggttatcgg aataaccagg     5220

ccagtatact cgagcgacgg cacgatgtcc tcatgttcaa tcaaggttgg cagcaatatg     5280

gcaatgtgat taacgagatc gtaaccgtgg gcctgggata taagaccgcc ctgcggaagg     5340

cgttgtatac ttttgcagaa ggctttaaga ataaggattt taagggtgcc ggcgtgagtg     5400

tccatgaaac agctgaacgg cacttttatc ggcagtccga gctgttgata ccagacgtgc     5460

tggctaatgt gaacttctca caggccgacg aagtgatcgc tgatctgcgg gataaactgc     5520

accaactgtg cgagatgctg tttaatcaaa gcgtcgctcc ttatgcccac cacccaaagc     5580

tgatctccac gctggccctg gcgcgcgcca cactttataa acatctccgc gaactgaaac     5640

cccagggggg ccccagcaat ggcgctgacc caactaacag agctaagggc ctggaggccg     5700

tatctgtggc atcaatggag cccttcaagt acatctgcca ctattggggc aagagctcca     5760

agagcctgac aaagggcaac gacatccacc tgctgatcta ccactgcctg gacgtggcag     5820

cagtggcaga ttgttggtgg gaccagtctg tggtgctgca gaataccttt tgtcggaacg     5880

agatgctgag caagcagaga gtgaaggcct ggctgctgtt ctttatcgcc ctgcacgaca     5940

tcggcaagtt cgacatcagg tttcagtata agtccgccga gtcttggctg aagctgaatc     6000

cagccacacc cagcctgaac ggcccttcca cccagatgtg caggaagttc aatcacggcg     6060

cagcaggact gtactggttt aaccaggact ctctgagcga gcagtccctg ggcgatttct     6120

tttctttctt tgacgcagca cctcacccct acgagagctg gttcccttgg gtggaggcag     6180

tgacaggaca ccacggcttt atcctgcaca gccaggacca ggataagtcc aggtgggaga     6240

tgccagccag cctggcctcc tacgccgcac aggataagca ggcccgcgag gagtggatct     6300

ccgtgctgga ggccctgttc ctgaccccag caggactgtc tatcaatgac atcccccctg     6360

actgctctag cctgctggcc ggcttttgtt ctctggccga ctggctgggc agctggacca     6420

caaccaatac attcctgttt aacgaggatg caccatccga catcaacgca ctgcgcacct     6480

acttccagga taggcagcag gacgccagcc gggtgctgga gctgtccggc ctggtgtcta     6540

ataagcggtg ctacgaggga gtgcacgcac tgctggataa cggctatcag cccagacagc     6600

tgcaggtgct ggtggacgca ctgcctgtgg caccaggact gacagtgatc gaggcaccta     6660

ccggctccgg caagacagag accgccctgg cctatgcctg gaagctgatc gatcagcaga     6720

tcgccgactc tgtgatcttc gccctgccaa cacaggccac cgccaatgcc atgctgacca     6780

ggatggaggc ctccgcctct cacctgtttt cctctcccaa cctgatcctg gcccacggca     6840

acagccggtt caatcacctg tttcagtcta tcaagagcag agccatcaca gagcagggac     6900

aggaggaggc ctgggtgcag tgctgtcagt ggctgagcca gtccaataag aaggtgttcc     6960

tgggccagat cggcgtgtgc accatcgatc aggtgctgat cagcgtgctg cctgtgaagc     7020

acaggtttat caggggactg ggaatcggcc gctccgtgct gatcgtggat gaggtgcacg     7080

cctacgacac atatatgaac ggcctgctgg aggccgtgct gaaggcacag gcagacgtgg     7140

gcggctctgt gatcctgctg agcgccaccc tgccaatgaa gcagaagcag aagctgctgg     7200

atacatacgg cctgcacacc gaccccgtgg agaacaattc tgcctatcct ctgatcaatt     7260

ggaggggagt gaacggagca cagcggttcg acctgctggc ccaccctgag cagctgccac     7320

cacggttttc catccagccc gagcctatct gcctggccga tatgctgcca gacctgacca     7380

tgctggagag aatgatcgct gccgccaatg caggagcaca ggtgtgcctg atctgtaacc     7440

tggtggatgt ggcccaggtg tgctaccagc ggctgaagga gctgaacaat acacaggtgg     7500

acatcgatct gttccacgcc aggtttaccc tgaatgaccg gagagagaag gagaaccgcg     7560

tgatcagcaa cttcggcaag aatggcaaga gaaacgtggg cagaatcctg gtggccacac     7620

aggtggtgga gcagtccctg gacgtggatt tcgactggct gatcacccag cactgccccg     7680

ccgatctgct gtttcagcgg ctgggcagac tgcacaggca ccaccgcaag tataggcctg     7740

caggattcga gatcccagtg gcaacaatcc tgctgcctga cggagaggga tacggccggc     7800

acgagcacat ctatagcaat gtgcgcgtga tgtggcggac ccagcagcac atcgaggagc     7860

tgaacggcgc cagcctgttc tttccagatg cctacagaca gtggctggac tccatctatg     7920

acgatgccga gatggatgag cccgagtggg tgggcaatgg catggacaag ttcgagtccg     7980

ccgagtgtga gaagcggttc aaggccagga aggtgctgca gtgggccgag gagtactctc     8040

tgcaggataa cgacgagaca atcctggccg tgacccggga cggagagatg agcctgccac     8100

tgctgcctta tgtgcagaca agctccggca agcagctgct ggatggccag gtgtacgagg     8160

acctgagcca cgagcagcag tatgaggccc tggccctgaa cagggtgaat gtgcccttca     8220

cctggaagcg gagcttcagc gaagtggtgg atgaggacgg cctgctgtgg ctggagggca     8280

agcagaatct ggatggctgg gtgtggcagg gcaactccat cgtgatcaca tacaccggcg     8340

acgagggcat gaccagagtg atcccagcca accccaagta ataatctaga gggccctatt     8400

ctatagtgtc acctaaatgc tagagctcgc tgatcagcct cgactgtgcc ttctagttgc     8460

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     8520

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     8580

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     8640

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct     8700

agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     8760

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     8820

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     8880

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     8940

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     9000

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     9060

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     9120

taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg tgtggaaagt     9180

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     9240

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     9300

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     9360

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     9420

cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     9480

gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag acaggatgag     9540

gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg     9600

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt     9660

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc     9720

tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt     9780

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag     9840

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg     9900

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag     9960

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg    10020

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc    10080

gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca    10140

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc    10200

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg    10260

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct    10320

atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga ccgaccaagc    10380

gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg aaaggttggg    10440

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct    10500

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa    10560

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc    10620

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc    10680

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa    10740

catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac    10800

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca    10860

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc    10920

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc    10980

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc    11040

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag    11100

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc    11160

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt    11220

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct    11280

ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg    11340

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct    11400

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat    11460

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg    11520

ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa    11580

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt    11640

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc    11700

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt    11760

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta    11820

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat    11880

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac    11940

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg    12000

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag    12060

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt    12120

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt    12180

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt    12240

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt    12300

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct    12360

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt    12420

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac    12480

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa    12540

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa    12600

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca    12660

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct    12720

ttttcattat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga    12780

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc    12840

tgacgtc                                                              12847


<210>  1877
<211>  12850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas3-17aa-Cas5 fusion

<400>  1877
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgga gcccttcaag tacatctgcc actattgggg caagagctcc aagagcctga     2760

caaagggcaa cgacatccac ctgctgatct accactgcct ggacgtggca gcagtggcag     2820

attgttggtg ggaccagtct gtggtgctgc agaatacctt ttgtcggaac gagatgctga     2880

gcaagcagag agtgaaggcc tggctgctgt tctttatcgc cctgcacgac atcggcaagt     2940

tcgacatcag gtttcagtat aagtccgccg agtcttggct gaagctgaat ccagccacac     3000

ccagcctgaa cggcccttcc acccagatgt gcaggaagtt caatcacggc gcagcaggac     3060

tgtactggtt taaccaggac tctctgagcg agcagtccct gggcgatttc ttttctttct     3120

ttgacgcagc acctcacccc tacgagagct ggttcccttg ggtggaggca gtgacaggac     3180

accacggctt tatcctgcac agccaggacc aggataagtc caggtgggag atgccagcca     3240

gcctggcctc ctacgccgca caggataagc aggcccgcga ggagtggatc tccgtgctgg     3300

aggccctgtt cctgacccca gcaggactgt ctatcaatga catcccccct gactgctcta     3360

gcctgctggc cggcttttgt tctctggccg actggctggg cagctggacc acaaccaata     3420

cattcctgtt taacgaggat gcaccatccg acatcaacgc actgcgcacc tacttccagg     3480

ataggcagca ggacgccagc cgggtgctgg agctgtccgg cctggtgtct aataagcggt     3540

gctacgaggg agtgcacgca ctgctggata acggctatca gcccagacag ctgcaggtgc     3600

tggtggacgc actgcctgtg gcaccaggac tgacagtgat cgaggcacct accggctccg     3660

gcaagacaga gaccgccctg gcctatgcct ggaagctgat cgatcagcag atcgccgact     3720

ctgtgatctt cgccctgcca acacaggcca ccgccaatgc catgctgacc aggatggagg     3780

cctccgcctc tcacctgttt tcctctccca acctgatcct ggcccacggc aacagccggt     3840

tcaatcacct gtttcagtct atcaagagca gagccatcac agagcaggga caggaggagg     3900

cctgggtgca gtgctgtcag tggctgagcc agtccaataa gaaggtgttc ctgggccaga     3960

tcggcgtgtg caccatcgat caggtgctga tcagcgtgct gcctgtgaag cacaggttta     4020

tcaggggact gggaatcggc cgctccgtgc tgatcgtgga tgaggtgcac gcctacgaca     4080

catatatgaa cggcctgctg gaggccgtgc tgaaggcaca ggcagacgtg ggcggctctg     4140

tgatcctgct gagcgccacc ctgccaatga agcagaagca gaagctgctg gatacatacg     4200

gcctgcacac cgaccccgtg gagaacaatt ctgcctatcc tctgatcaat tggaggggag     4260

tgaacggagc acagcggttc gacctgctgg cccaccctga gcagctgcca ccacggtttt     4320

ccatccagcc cgagcctatc tgcctggccg atatgctgcc agacctgacc atgctggaga     4380

gaatgatcgc tgccgccaat gcaggagcac aggtgtgcct gatctgtaac ctggtggatg     4440

tggcccaggt gtgctaccag cggctgaagg agctgaacaa tacacaggtg gacatcgatc     4500

tgttccacgc caggtttacc ctgaatgacc ggagagagaa ggagaaccgc gtgatcagca     4560

acttcggcaa gaatggcaag agaaacgtgg gcagaatcct ggtggccaca caggtggtgg     4620

agcagtccct ggacgtggat ttcgactggc tgatcaccca gcactgcccc gccgatctgc     4680

tgtttcagcg gctgggcaga ctgcacaggc accaccgcaa gtataggcct gcaggattcg     4740

agatcccagt ggcaacaatc ctgctgcctg acggagaggg atacggccgg cacgagcaca     4800

tctatagcaa tgtgcgcgtg atgtggcgga cccagcagca catcgaggag ctgaacggcg     4860

ccagcctgtt ctttccagat gcctacagac agtggctgga ctccatctat gacgatgccg     4920

agatggatga gcccgagtgg gtgggcaatg gcatggacaa gttcgagtcc gccgagtgtg     4980

agaagcggtt caaggccagg aaggtgctgc agtgggccga ggagtactct ctgcaggata     5040

acgacgagac aatcctggcc gtgacccggg acggagagat gagcctgcca ctgctgcctt     5100

atgtgcagac aagctccggc aagcagctgc tggatggcca ggtgtacgag gacctgagcc     5160

acgagcagca gtatgaggcc ctggccctga acagggtgaa tgtgcccttc acctggaagc     5220

ggagcttcag cgaagtggtg gatgaggacg gcctgctgtg gctggagggc aagcagaatc     5280

tggatggctg ggtgtggcag ggcaactcca tcgtgatcac atacaccggc gacgagggca     5340

tgaccagagt gatcccagcc aaccccaagg ctgacccaac taacagagct aagggcctgg     5400

aggccgtatc tgtggcatca atgcggagct atctcatcct gagactggcc ggaccaatgc     5460

aggcctgggg acagcctacc ttcgaaggta cacgccccac aggccgcttt cctaccagga     5520

gcggcctgct gggcctgctt ggcgcttgtc ttgggatcca gcgcgatgat actagctccc     5580

tgcaagcact gtcagagagc gtgcagtttg ccgtaagatg cgacgaactg atccttgatg     5640

ataggcgggt cagtgtcact ggtctccggg actaccacac ggtgctgggg gcccgggagg     5700

attatagggg cctgaaaagt cacgagacga ttcaaacctg gcgcgaatat ctgtgcgatg     5760

ccagcttcac cgtggccctg tggctgactc cacatgccac tatggtcatc agtgaactgg     5820

aaaaggctgt tcttaagcct cgatatactc cgtatctggg ccgccggagt tgtccactta     5880

cacacccact tttcctcggc acctgccagg ccagcgaccc tcaaaaggcc cttctgaatt     5940

acgagccagt tggcggtgac atatacagcg aagagtccgt gacgggacac catcttaagt     6000

tcaccgctcg ggacgagccc atgattaccc tcccacggca gttcgcatca agggagtggt     6060

acgtcataaa ggggggcatg gatgtgagtc aggggtctgg ggaggggcgg gggtctttgt     6120

tgacttgcgg ggatgttgag gagaatcctg gacctcccaa aaaaaaacgg aaggtgggct     6180

caggcatgta tctgtcaaag gttatcattg cacgcgcgtg gagtagggat ctgtatcagc     6240

tgcaccaggg tctgtggcat cttttcccga accgccccga cgcggcacga gactttctgt     6300

ttcacgttga aaaaagaaac acccccgagg gctgtcatgt gctcctgcag tctgcccaga     6360

tgccggtgag cacagctgtg gcgactgtga tcaagaccaa gcaggtcgag tttcagctcc     6420

aggtaggggt tccactgtat tttcgcctga gagctaatcc gatcaaaacc atactggata     6480

atcagaagag gctcgacagc aaaggaaata ttaaaaggtg ccgggtcccg ctcatcaaag     6540

aggctgagca aatcgcttgg cttcaacgga aactggggaa cgcagcccgc gtggaagacg     6600

tccacccgat tagtgaacgg ccccaatatt tttccggaga cggaaagagc ggcaagattc     6660

agacagtctg tttcgagggg gtgctcacca tcaatgatgc ccccgccctg atagacctgg     6720

tgcagcaggg cataggcccc gctaaaagca tgggatgcgg actgcttagt ctggcaccgc     6780

tgggatccgg agagggcaga ggaagtctgc taacatgcgg tgacgtcgag gagaatcctg     6840

gacctcccaa gaaaaagaga aaagtaggat cgggcatgaa tttgctcatt gataattgga     6900

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     6960

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     7020

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     7080

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     7140

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     7200

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     7260

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     7320

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     7380

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     7440

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     7500

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     7560

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     7620

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     7680

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     7740

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     7800

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     7860

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     7920

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     7980

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     8040

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     8100

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     8160

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     8220

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     8280

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     8340

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     8400

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     8460

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     8520

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     8580

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     8640

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     8700

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     8760

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     8820

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     8880

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     8940

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     9000

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     9060

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     9120

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     9180

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     9240

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     9300

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     9360

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     9420

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     9480

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     9540

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     9600

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     9660

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     9720

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     9780

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     9840

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     9900

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     9960

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg    10020

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg    10080

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata    10140

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg    10200

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat    10260

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct    10320

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca    10380

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt    10440

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat    10500

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag    10560

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt    10620

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt    10680

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca    10740

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact    10800

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct    10860

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc    10920

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca    10980

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg    11040

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca    11100

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa    11160

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc    11220

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc    11280

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct    11340

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg    11400

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag    11460

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta    11520

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg    11580

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt    11640

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt    11700

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag    11760

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat    11820

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc    11880

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat    11940

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc    12000

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag    12060

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag    12120

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt    12180

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg    12240

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt    12300

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc    12360

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc    12420

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa    12480

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg    12540

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc    12600

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag    12660

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt    12720

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt    12780

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc    12840

acctgacgtc                                                           12850


<210>  1878
<211>  12850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas5-17aa-Cas3 fusion

<400>  1878
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcaggct gacccaacta acagagctaa gggcctggag gccgtatctg     3420

tggcatcaat ggagcccttc aagtacatct gccactattg gggcaagagc tccaagagcc     3480

tgacaaaggg caacgacatc cacctgctga tctaccactg cctggacgtg gcagcagtgg     3540

cagattgttg gtgggaccag tctgtggtgc tgcagaatac cttttgtcgg aacgagatgc     3600

tgagcaagca gagagtgaag gcctggctgc tgttctttat cgccctgcac gacatcggca     3660

agttcgacat caggtttcag tataagtccg ccgagtcttg gctgaagctg aatccagcca     3720

cacccagcct gaacggccct tccacccaga tgtgcaggaa gttcaatcac ggcgcagcag     3780

gactgtactg gtttaaccag gactctctga gcgagcagtc cctgggcgat ttcttttctt     3840

tctttgacgc agcacctcac ccctacgaga gctggttccc ttgggtggag gcagtgacag     3900

gacaccacgg ctttatcctg cacagccagg accaggataa gtccaggtgg gagatgccag     3960

ccagcctggc ctcctacgcc gcacaggata agcaggcccg cgaggagtgg atctccgtgc     4020

tggaggccct gttcctgacc ccagcaggac tgtctatcaa tgacatcccc cctgactgct     4080

ctagcctgct ggccggcttt tgttctctgg ccgactggct gggcagctgg accacaacca     4140

atacattcct gtttaacgag gatgcaccat ccgacatcaa cgcactgcgc acctacttcc     4200

aggataggca gcaggacgcc agccgggtgc tggagctgtc cggcctggtg tctaataagc     4260

ggtgctacga gggagtgcac gcactgctgg ataacggcta tcagcccaga cagctgcagg     4320

tgctggtgga cgcactgcct gtggcaccag gactgacagt gatcgaggca cctaccggct     4380

ccggcaagac agagaccgcc ctggcctatg cctggaagct gatcgatcag cagatcgccg     4440

actctgtgat cttcgccctg ccaacacagg ccaccgccaa tgccatgctg accaggatgg     4500

aggcctccgc ctctcacctg ttttcctctc ccaacctgat cctggcccac ggcaacagcc     4560

ggttcaatca cctgtttcag tctatcaaga gcagagccat cacagagcag ggacaggagg     4620

aggcctgggt gcagtgctgt cagtggctga gccagtccaa taagaaggtg ttcctgggcc     4680

agatcggcgt gtgcaccatc gatcaggtgc tgatcagcgt gctgcctgtg aagcacaggt     4740

ttatcagggg actgggaatc ggccgctccg tgctgatcgt ggatgaggtg cacgcctacg     4800

acacatatat gaacggcctg ctggaggccg tgctgaaggc acaggcagac gtgggcggct     4860

ctgtgatcct gctgagcgcc accctgccaa tgaagcagaa gcagaagctg ctggatacat     4920

acggcctgca caccgacccc gtggagaaca attctgccta tcctctgatc aattggaggg     4980

gagtgaacgg agcacagcgg ttcgacctgc tggcccaccc tgagcagctg ccaccacggt     5040

tttccatcca gcccgagcct atctgcctgg ccgatatgct gccagacctg accatgctgg     5100

agagaatgat cgctgccgcc aatgcaggag cacaggtgtg cctgatctgt aacctggtgg     5160

atgtggccca ggtgtgctac cagcggctga aggagctgaa caatacacag gtggacatcg     5220

atctgttcca cgccaggttt accctgaatg accggagaga gaaggagaac cgcgtgatca     5280

gcaacttcgg caagaatggc aagagaaacg tgggcagaat cctggtggcc acacaggtgg     5340

tggagcagtc cctggacgtg gatttcgact ggctgatcac ccagcactgc cccgccgatc     5400

tgctgtttca gcggctgggc agactgcaca ggcaccaccg caagtatagg cctgcaggat     5460

tcgagatccc agtggcaaca atcctgctgc ctgacggaga gggatacggc cggcacgagc     5520

acatctatag caatgtgcgc gtgatgtggc ggacccagca gcacatcgag gagctgaacg     5580

gcgccagcct gttctttcca gatgcctaca gacagtggct ggactccatc tatgacgatg     5640

ccgagatgga tgagcccgag tgggtgggca atggcatgga caagttcgag tccgccgagt     5700

gtgagaagcg gttcaaggcc aggaaggtgc tgcagtgggc cgaggagtac tctctgcagg     5760

ataacgacga gacaatcctg gccgtgaccc gggacggaga gatgagcctg ccactgctgc     5820

cttatgtgca gacaagctcc ggcaagcagc tgctggatgg ccaggtgtac gaggacctga     5880

gccacgagca gcagtatgag gccctggccc tgaacagggt gaatgtgccc ttcacctgga     5940

agcggagctt cagcgaagtg gtggatgagg acggcctgct gtggctggag ggcaagcaga     6000

atctggatgg ctgggtgtgg cagggcaact ccatcgtgat cacatacacc ggcgacgagg     6060

gcatgaccag agtgatccca gccaacccca aggggtctgg ggaggggcgg gggtctttgt     6120

tgacttgcgg ggatgttgag gagaatcctg gacctcccaa aaaaaaacgg aaggtgggct     6180

caggcatgta tctgtcaaag gttatcattg cacgcgcgtg gagtagggat ctgtatcagc     6240

tgcaccaggg tctgtggcat cttttcccga accgccccga cgcggcacga gactttctgt     6300

ttcacgttga aaaaagaaac acccccgagg gctgtcatgt gctcctgcag tctgcccaga     6360

tgccggtgag cacagctgtg gcgactgtga tcaagaccaa gcaggtcgag tttcagctcc     6420

aggtaggggt tccactgtat tttcgcctga gagctaatcc gatcaaaacc atactggata     6480

atcagaagag gctcgacagc aaaggaaata ttaaaaggtg ccgggtcccg ctcatcaaag     6540

aggctgagca aatcgcttgg cttcaacgga aactggggaa cgcagcccgc gtggaagacg     6600

tccacccgat tagtgaacgg ccccaatatt tttccggaga cggaaagagc ggcaagattc     6660

agacagtctg tttcgagggg gtgctcacca tcaatgatgc ccccgccctg atagacctgg     6720

tgcagcaggg cataggcccc gctaaaagca tgggatgcgg actgcttagt ctggcaccgc     6780

tgggatccgg agagggcaga ggaagtctgc taacatgcgg tgacgtcgag gagaatcctg     6840

gacctcccaa gaaaaagaga aaagtaggat cgggcatgaa tttgctcatt gataattgga     6900

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     6960

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     7020

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     7080

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     7140

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     7200

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     7260

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     7320

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     7380

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     7440

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     7500

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     7560

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     7620

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     7680

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     7740

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     7800

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     7860

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     7920

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     7980

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     8040

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     8100

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     8160

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     8220

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     8280

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     8340

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     8400

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     8460

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     8520

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     8580

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     8640

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     8700

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     8760

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     8820

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     8880

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     8940

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     9000

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     9060

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     9120

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     9180

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     9240

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     9300

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     9360

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     9420

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     9480

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     9540

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     9600

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     9660

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     9720

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     9780

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     9840

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     9900

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     9960

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg    10020

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg    10080

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata    10140

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg    10200

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat    10260

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct    10320

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca    10380

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt    10440

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat    10500

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag    10560

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt    10620

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt    10680

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca    10740

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact    10800

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct    10860

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc    10920

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca    10980

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg    11040

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca    11100

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa    11160

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc    11220

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc    11280

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct    11340

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg    11400

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag    11460

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta    11520

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg    11580

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt    11640

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt    11700

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag    11760

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat    11820

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc    11880

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat    11940

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc    12000

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag    12060

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag    12120

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt    12180

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg    12240

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt    12300

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc    12360

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc    12420

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa    12480

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg    12540

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc    12600

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag    12660

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt    12720

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt    12780

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc    12840

acctgacgtc                                                           12850


<210>  1879
<211>  12850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas3-17aa-Cas6 fusion

<400>  1879
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcaggga tccggagaag gaaggggatc cctcctcaca tgtggagatg     3420

tcgaagaaaa tcctggacct cccaagaaaa agagaaaagt aggatcgggc atggagccct     3480

tcaagtacat ctgccactat tggggcaaga gctccaagag cctgacaaag ggcaacgaca     3540

tccacctgct gatctaccac tgcctggacg tggcagcagt ggcagattgt tggtgggacc     3600

agtctgtggt gctgcagaat accttttgtc ggaacgagat gctgagcaag cagagagtga     3660

aggcctggct gctgttcttt atcgccctgc acgacatcgg caagttcgac atcaggtttc     3720

agtataagtc cgccgagtct tggctgaagc tgaatccagc cacacccagc ctgaacggcc     3780

cttccaccca gatgtgcagg aagttcaatc acggcgcagc aggactgtac tggtttaacc     3840

aggactctct gagcgagcag tccctgggcg atttcttttc tttctttgac gcagcacctc     3900

acccctacga gagctggttc ccttgggtgg aggcagtgac aggacaccac ggctttatcc     3960

tgcacagcca ggaccaggat aagtccaggt gggagatgcc agccagcctg gcctcctacg     4020

ccgcacagga taagcaggcc cgcgaggagt ggatctccgt gctggaggcc ctgttcctga     4080

ccccagcagg actgtctatc aatgacatcc cccctgactg ctctagcctg ctggccggct     4140

tttgttctct ggccgactgg ctgggcagct ggaccacaac caatacattc ctgtttaacg     4200

aggatgcacc atccgacatc aacgcactgc gcacctactt ccaggatagg cagcaggacg     4260

ccagccgggt gctggagctg tccggcctgg tgtctaataa gcggtgctac gagggagtgc     4320

acgcactgct ggataacggc tatcagccca gacagctgca ggtgctggtg gacgcactgc     4380

ctgtggcacc aggactgaca gtgatcgagg cacctaccgg ctccggcaag acagagaccg     4440

ccctggccta tgcctggaag ctgatcgatc agcagatcgc cgactctgtg atcttcgccc     4500

tgccaacaca ggccaccgcc aatgccatgc tgaccaggat ggaggcctcc gcctctcacc     4560

tgttttcctc tcccaacctg atcctggccc acggcaacag ccggttcaat cacctgtttc     4620

agtctatcaa gagcagagcc atcacagagc agggacagga ggaggcctgg gtgcagtgct     4680

gtcagtggct gagccagtcc aataagaagg tgttcctggg ccagatcggc gtgtgcacca     4740

tcgatcaggt gctgatcagc gtgctgcctg tgaagcacag gtttatcagg ggactgggaa     4800

tcggccgctc cgtgctgatc gtggatgagg tgcacgccta cgacacatat atgaacggcc     4860

tgctggaggc cgtgctgaag gcacaggcag acgtgggcgg ctctgtgatc ctgctgagcg     4920

ccaccctgcc aatgaagcag aagcagaagc tgctggatac atacggcctg cacaccgacc     4980

ccgtggagaa caattctgcc tatcctctga tcaattggag gggagtgaac ggagcacagc     5040

ggttcgacct gctggcccac cctgagcagc tgccaccacg gttttccatc cagcccgagc     5100

ctatctgcct ggccgatatg ctgccagacc tgaccatgct ggagagaatg atcgctgccg     5160

ccaatgcagg agcacaggtg tgcctgatct gtaacctggt ggatgtggcc caggtgtgct     5220

accagcggct gaaggagctg aacaatacac aggtggacat cgatctgttc cacgccaggt     5280

ttaccctgaa tgaccggaga gagaaggaga accgcgtgat cagcaacttc ggcaagaatg     5340

gcaagagaaa cgtgggcaga atcctggtgg ccacacaggt ggtggagcag tccctggacg     5400

tggatttcga ctggctgatc acccagcact gccccgccga tctgctgttt cagcggctgg     5460

gcagactgca caggcaccac cgcaagtata ggcctgcagg attcgagatc ccagtggcaa     5520

caatcctgct gcctgacgga gagggatacg gccggcacga gcacatctat agcaatgtgc     5580

gcgtgatgtg gcggacccag cagcacatcg aggagctgaa cggcgccagc ctgttctttc     5640

cagatgccta cagacagtgg ctggactcca tctatgacga tgccgagatg gatgagcccg     5700

agtgggtggg caatggcatg gacaagttcg agtccgccga gtgtgagaag cggttcaagg     5760

ccaggaaggt gctgcagtgg gccgaggagt actctctgca ggataacgac gagacaatcc     5820

tggccgtgac ccgggacgga gagatgagcc tgccactgct gccttatgtg cagacaagct     5880

ccggcaagca gctgctggat ggccaggtgt acgaggacct gagccacgag cagcagtatg     5940

aggccctggc cctgaacagg gtgaatgtgc ccttcacctg gaagcggagc ttcagcgaag     6000

tggtggatga ggacggcctg ctgtggctgg agggcaagca gaatctggat ggctgggtgt     6060

ggcagggcaa ctccatcgtg atcacataca ccggcgacga gggcatgacc agagtgatcc     6120

cagccaaccc caaggctgac ccaactaaca gagctaaggg cctggaggcc gtatctgtgg     6180

catcaatgta tctgtcaaag gttatcattg cacgcgcgtg gagtagggat ctgtatcagc     6240

tgcaccaggg tctgtggcat cttttcccga accgccccga cgcggcacga gactttctgt     6300

ttcacgttga aaaaagaaac acccccgagg gctgtcatgt gctcctgcag tctgcccaga     6360

tgccggtgag cacagctgtg gcgactgtga tcaagaccaa gcaggtcgag tttcagctcc     6420

aggtaggggt tccactgtat tttcgcctga gagctaatcc gatcaaaacc atactggata     6480

atcagaagag gctcgacagc aaaggaaata ttaaaaggtg ccgggtcccg ctcatcaaag     6540

aggctgagca aatcgcttgg cttcaacgga aactggggaa cgcagcccgc gtggaagacg     6600

tccacccgat tagtgaacgg ccccaatatt tttccggaga cggaaagagc ggcaagattc     6660

agacagtctg tttcgagggg gtgctcacca tcaatgatgc ccccgccctg atagacctgg     6720

tgcagcaggg cataggcccc gctaaaagca tgggatgcgg actgcttagt ctggcaccgc     6780

tgggatccgg agagggcaga ggaagtctgc taacatgcgg tgacgtcgag gagaatcctg     6840

gacctcccaa gaaaaagaga aaagtaggat cgggcatgaa tttgctcatt gataattgga     6900

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     6960

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     7020

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     7080

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     7140

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     7200

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     7260

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     7320

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     7380

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     7440

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     7500

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     7560

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     7620

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     7680

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     7740

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     7800

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     7860

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     7920

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     7980

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     8040

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     8100

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     8160

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     8220

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     8280

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     8340

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     8400

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     8460

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     8520

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     8580

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     8640

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     8700

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     8760

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     8820

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     8880

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     8940

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     9000

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     9060

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     9120

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     9180

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     9240

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     9300

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     9360

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     9420

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     9480

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     9540

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     9600

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     9660

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     9720

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     9780

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     9840

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     9900

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     9960

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg    10020

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg    10080

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata    10140

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg    10200

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat    10260

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct    10320

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca    10380

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt    10440

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat    10500

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag    10560

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt    10620

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt    10680

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca    10740

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact    10800

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct    10860

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc    10920

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca    10980

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg    11040

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca    11100

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa    11160

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc    11220

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc    11280

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct    11340

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg    11400

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag    11460

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta    11520

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg    11580

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt    11640

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt    11700

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag    11760

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat    11820

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc    11880

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat    11940

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc    12000

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag    12060

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag    12120

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt    12180

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg    12240

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt    12300

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc    12360

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc    12420

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa    12480

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg    12540

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc    12600

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag    12660

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt    12720

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt    12780

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc    12840

acctgacgtc                                                           12850


<210>  1880
<211>  12850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas6-17aa-Cas3 fusion

<400>  1880
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcaggga tccggagaag gaaggggatc cctcctcaca tgtggagatg     3420

tcgaagaaaa tcctggacct cccaagaaaa agagaaaagt aggatcgggc atgtatctgt     3480

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     3540

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     3600

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     3660

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     3720

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     3780

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     3840

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     3900

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     3960

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     4020

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctggct gacccaacta     4080

acagagctaa gggcctggag gccgtatctg tggcatcaat ggagcccttc aagtacatct     4140

gccactattg gggcaagagc tccaagagcc tgacaaaggg caacgacatc cacctgctga     4200

tctaccactg cctggacgtg gcagcagtgg cagattgttg gtgggaccag tctgtggtgc     4260

tgcagaatac cttttgtcgg aacgagatgc tgagcaagca gagagtgaag gcctggctgc     4320

tgttctttat cgccctgcac gacatcggca agttcgacat caggtttcag tataagtccg     4380

ccgagtcttg gctgaagctg aatccagcca cacccagcct gaacggccct tccacccaga     4440

tgtgcaggaa gttcaatcac ggcgcagcag gactgtactg gtttaaccag gactctctga     4500

gcgagcagtc cctgggcgat ttcttttctt tctttgacgc agcacctcac ccctacgaga     4560

gctggttccc ttgggtggag gcagtgacag gacaccacgg ctttatcctg cacagccagg     4620

accaggataa gtccaggtgg gagatgccag ccagcctggc ctcctacgcc gcacaggata     4680

agcaggcccg cgaggagtgg atctccgtgc tggaggccct gttcctgacc ccagcaggac     4740

tgtctatcaa tgacatcccc cctgactgct ctagcctgct ggccggcttt tgttctctgg     4800

ccgactggct gggcagctgg accacaacca atacattcct gtttaacgag gatgcaccat     4860

ccgacatcaa cgcactgcgc acctacttcc aggataggca gcaggacgcc agccgggtgc     4920

tggagctgtc cggcctggtg tctaataagc ggtgctacga gggagtgcac gcactgctgg     4980

ataacggcta tcagcccaga cagctgcagg tgctggtgga cgcactgcct gtggcaccag     5040

gactgacagt gatcgaggca cctaccggct ccggcaagac agagaccgcc ctggcctatg     5100

cctggaagct gatcgatcag cagatcgccg actctgtgat cttcgccctg ccaacacagg     5160

ccaccgccaa tgccatgctg accaggatgg aggcctccgc ctctcacctg ttttcctctc     5220

ccaacctgat cctggcccac ggcaacagcc ggttcaatca cctgtttcag tctatcaaga     5280

gcagagccat cacagagcag ggacaggagg aggcctgggt gcagtgctgt cagtggctga     5340

gccagtccaa taagaaggtg ttcctgggcc agatcggcgt gtgcaccatc gatcaggtgc     5400

tgatcagcgt gctgcctgtg aagcacaggt ttatcagggg actgggaatc ggccgctccg     5460

tgctgatcgt ggatgaggtg cacgcctacg acacatatat gaacggcctg ctggaggccg     5520

tgctgaaggc acaggcagac gtgggcggct ctgtgatcct gctgagcgcc accctgccaa     5580

tgaagcagaa gcagaagctg ctggatacat acggcctgca caccgacccc gtggagaaca     5640

attctgccta tcctctgatc aattggaggg gagtgaacgg agcacagcgg ttcgacctgc     5700

tggcccaccc tgagcagctg ccaccacggt tttccatcca gcccgagcct atctgcctgg     5760

ccgatatgct gccagacctg accatgctgg agagaatgat cgctgccgcc aatgcaggag     5820

cacaggtgtg cctgatctgt aacctggtgg atgtggccca ggtgtgctac cagcggctga     5880

aggagctgaa caatacacag gtggacatcg atctgttcca cgccaggttt accctgaatg     5940

accggagaga gaaggagaac cgcgtgatca gcaacttcgg caagaatggc aagagaaacg     6000

tgggcagaat cctggtggcc acacaggtgg tggagcagtc cctggacgtg gatttcgact     6060

ggctgatcac ccagcactgc cccgccgatc tgctgtttca gcggctgggc agactgcaca     6120

ggcaccaccg caagtatagg cctgcaggat tcgagatccc agtggcaaca atcctgctgc     6180

ctgacggaga gggatacggc cggcacgagc acatctatag caatgtgcgc gtgatgtggc     6240

ggacccagca gcacatcgag gagctgaacg gcgccagcct gttctttcca gatgcctaca     6300

gacagtggct ggactccatc tatgacgatg ccgagatgga tgagcccgag tgggtgggca     6360

atggcatgga caagttcgag tccgccgagt gtgagaagcg gttcaaggcc aggaaggtgc     6420

tgcagtgggc cgaggagtac tctctgcagg ataacgacga gacaatcctg gccgtgaccc     6480

gggacggaga gatgagcctg ccactgctgc cttatgtgca gacaagctcc ggcaagcagc     6540

tgctggatgg ccaggtgtac gaggacctga gccacgagca gcagtatgag gccctggccc     6600

tgaacagggt gaatgtgccc ttcacctgga agcggagctt cagcgaagtg gtggatgagg     6660

acggcctgct gtggctggag ggcaagcaga atctggatgg ctgggtgtgg cagggcaact     6720

ccatcgtgat cacatacacc ggcgacgagg gcatgaccag agtgatccca gccaacccca     6780

agggatccgg agagggcaga ggaagtctgc taacatgcgg tgacgtcgag gagaatcctg     6840

gacctcccaa gaaaaagaga aaagtaggat cgggcatgaa tttgctcatt gataattgga     6900

ttccggtgcg cccccggaac ggtgggaaag tgcagatcat caatttgcaa agtctctact     6960

gttccaggga ccagtggaga ctcagcctgc cacgggatga tatggagctg gcggcgttgg     7020

ctctgctcgt atgcatcggc cagattattg cgccagcaaa ggatgacgtt gaattccggc     7080

atcggataat gaaccccctt actgaagatg agttccagca gcttatcgcc ccatggatcg     7140

acatgttcta cctcaaccac gccgagcatc cttttatgca gaccaaggga gtcaaggcga     7200

atgatgtgac tcccatggag aagctgctgg ccggtgtatc tggggcgacc aactgcgcat     7260

tcgtgaatca gcctggacag ggggaggccc tctgtggagg ctgcactgct atagcacttt     7320

ttaaccaagc taatcaagcc cccggctttg gtggagggtt taagagtgga ttgagggggg     7380

gcactcccgt aaccactttt gtgaggggaa ttgatctgag gtctactgtg ttgctgaacg     7440

tcctcacact cccaaggctc cagaagcagt tcccaaacga aagtcatacc gaaaaccagc     7500

ccacatggat caagcccatc aaatctaatg agagcatacc ggctagcagt attggatttg     7560

tacggggtct gttctggcag ccagctcaca tcgagctgtg tgatcctatt gggatcggca     7620

agtgctcttg ttgtgggcag gagtccaacc ttaggtatac tggatttctg aaagagaagt     7680

ttacctttac agtaaatggg ctctggcccc acccccactc accttgcctt gtgacagtga     7740

aaaaggggga agtcgaggag aagtttctgg cctttacaac ttctgcccct tcctggactc     7800

agatttccag agtggtggta gataagataa ttcaaaacga gaatggcaat agagtggccg     7860

ccgtggtgaa ccagtttcgc aacatcgccc ctcagtcccc cctggagctg attatgggcg     7920

gttatcggaa taaccaggcc agtatactcg agcgacggca cgatgtcctc atgttcaatc     7980

aaggttggca gcaatatggc aatgtgatta acgagatcgt aaccgtgggc ctgggatata     8040

agaccgccct gcggaaggcg ttgtatactt ttgcagaagg ctttaagaat aaggatttta     8100

agggtgccgg cgtgagtgtc catgaaacag ctgaacggca cttttatcgg cagtccgagc     8160

tgttgatacc agacgtgctg gctaatgtga acttctcaca ggccgacgaa gtgatcgctg     8220

atctgcggga taaactgcac caactgtgcg agatgctgtt taatcaaagc gtcgctcctt     8280

atgcccacca cccaaagctg atctccacgc tggccctggc gcgcgccaca ctttataaac     8340

atctccgcga actgaaaccc caggggggcc ccagcaatgg ctaataatct agagggccct     8400

attctatagt gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt     8460

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     8520

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     8580

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     8640

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     8700

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     8760

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     8820

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     8880

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     8940

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     9000

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     9060

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     9120

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     9180

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     9240

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     9300

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     9360

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     9420

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     9480

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     9540

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     9600

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     9660

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     9720

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     9780

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     9840

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     9900

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     9960

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg    10020

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg    10080

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata    10140

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg    10200

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat    10260

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct    10320

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgaaa tgaccgacca    10380

agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct atgaaaggtt    10440

gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat    10500

gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag    10560

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt    10620

gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt    10680

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca    10740

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact    10800

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct    10860

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc    10920

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca    10980

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg    11040

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca    11100

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa    11160

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc    11220

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc    11280

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct    11340

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg    11400

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag    11460

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta    11520

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg    11580

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt    11640

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt    11700

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag    11760

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat    11820

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc    11880

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat    11940

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc    12000

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag    12060

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag    12120

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt    12180

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg    12240

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt    12300

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc    12360

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc    12420

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa    12480

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg    12540

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc    12600

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag    12660

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt    12720

cctttttcat tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt    12780

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc    12840

acctgacgtc                                                           12850


<210>  1881
<211>  2488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas3-17aa-Cas8 fusion

<400>  1881

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            820                 825                 830         


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
        835                 840                 845             


Gly Ser Gly Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser 
    850                 855                 860                 


Arg Asp Leu Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn 
865                 870                 875                 880 


Arg Pro Asp Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn 
                885                 890                 895     


Thr Pro Glu Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val 
            900                 905                 910         


Ser Thr Ala Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln 
        915                 920                 925             


Leu Gln Val Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile 
    930                 935                 940                 


Lys Thr Ile Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile 
945                 950                 955                 960 


Lys Arg Cys Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp 
                965                 970                 975     


Leu Gln Arg Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro 
            980                 985                 990         


Ile Ser Glu Arg Pro Gln Tyr Phe  Ser Gly Asp Gly Lys  Ser Gly Lys 
        995                 1000                 1005             


Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu Thr Ile  Asn Asp Ala 
    1010                 1015                 1020             


Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly Ile Gly  Pro Ala Lys 
    1025                 1030                 1035             


Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala Pro Leu  Gly Ser Gly 
    1040                 1045                 1050             


Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn 
    1055                 1060                 1065             


Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Met Glu 
    1070                 1075                 1080             


Pro Phe  Lys Tyr Ile Cys His  Tyr Trp Gly Lys Ser  Ser Lys Ser 
    1085                 1090                 1095             


Leu Thr  Lys Gly Asn Asp Ile  His Leu Leu Ile Tyr  His Cys Leu 
    1100                 1105                 1110             


Asp Val  Ala Ala Val Ala Asp  Cys Trp Trp Asp Gln  Ser Val Val 
    1115                 1120                 1125             


Leu Gln  Asn Thr Phe Cys Arg  Asn Glu Met Leu Ser  Lys Gln Arg 
    1130                 1135                 1140             


Val Lys  Ala Trp Leu Leu Phe  Phe Ile Ala Leu His  Asp Ile Gly 
    1145                 1150                 1155             


Lys Phe  Asp Ile Arg Phe Gln  Tyr Lys Ser Ala Glu  Ser Trp Leu 
    1160                 1165                 1170             


Lys Leu  Asn Pro Ala Thr Pro  Ser Leu Asn Gly Pro  Ser Thr Gln 
    1175                 1180                 1185             


Met Cys  Arg Lys Phe Asn His  Gly Ala Ala Gly Leu  Tyr Trp Phe 
    1190                 1195                 1200             


Asn Gln  Asp Ser Leu Ser Glu  Gln Ser Leu Gly Asp  Phe Phe Ser 
    1205                 1210                 1215             


Phe Phe  Asp Ala Ala Pro His  Pro Tyr Glu Ser Trp  Phe Pro Trp 
    1220                 1225                 1230             


Val Glu  Ala Val Thr Gly His  His Gly Phe Ile Leu  His Ser Gln 
    1235                 1240                 1245             


Asp Gln  Asp Lys Ser Arg Trp  Glu Met Pro Ala Ser  Leu Ala Ser 
    1250                 1255                 1260             


Tyr Ala  Ala Gln Asp Lys Gln  Ala Arg Glu Glu Trp  Ile Ser Val 
    1265                 1270                 1275             


Leu Glu  Ala Leu Phe Leu Thr  Pro Ala Gly Leu Ser  Ile Asn Asp 
    1280                 1285                 1290             


Ile Pro  Pro Asp Cys Ser Ser  Leu Leu Ala Gly Phe  Cys Ser Leu 
    1295                 1300                 1305             


Ala Asp  Trp Leu Gly Ser Trp  Thr Thr Thr Asn Thr  Phe Leu Phe 
    1310                 1315                 1320             


Asn Glu  Asp Ala Pro Ser Asp  Ile Asn Ala Leu Arg  Thr Tyr Phe 
    1325                 1330                 1335             


Gln Asp  Arg Gln Gln Asp Ala  Ser Arg Val Leu Glu  Leu Ser Gly 
    1340                 1345                 1350             


Leu Val  Ser Asn Lys Arg Cys  Tyr Glu Gly Val His  Ala Leu Leu 
    1355                 1360                 1365             


Asp Asn  Gly Tyr Gln Pro Arg  Gln Leu Gln Val Leu  Val Asp Ala 
    1370                 1375                 1380             


Leu Pro  Val Ala Pro Gly Leu  Thr Val Ile Glu Ala  Pro Thr Gly 
    1385                 1390                 1395             


Ser Gly  Lys Thr Glu Thr Ala  Leu Ala Tyr Ala Trp  Lys Leu Ile 
    1400                 1405                 1410             


Asp Gln  Gln Ile Ala Asp Ser  Val Ile Phe Ala Leu  Pro Thr Gln 
    1415                 1420                 1425             


Ala Thr  Ala Asn Ala Met Leu  Thr Arg Met Glu Ala  Ser Ala Ser 
    1430                 1435                 1440             


His Leu  Phe Ser Ser Pro Asn  Leu Ile Leu Ala His  Gly Asn Ser 
    1445                 1450                 1455             


Arg Phe  Asn His Leu Phe Gln  Ser Ile Lys Ser Arg  Ala Ile Thr 
    1460                 1465                 1470             


Glu Gln  Gly Gln Glu Glu Ala  Trp Val Gln Cys Cys  Gln Trp Leu 
    1475                 1480                 1485             


Ser Gln  Ser Asn Lys Lys Val  Phe Leu Gly Gln Ile  Gly Val Cys 
    1490                 1495                 1500             


Thr Ile  Asp Gln Val Leu Ile  Ser Val Leu Pro Val  Lys His Arg 
    1505                 1510                 1515             


Phe Ile  Arg Gly Leu Gly Ile  Gly Arg Ser Val Leu  Ile Val Asp 
    1520                 1525                 1530             


Glu Val  His Ala Tyr Asp Thr  Tyr Met Asn Gly Leu  Leu Glu Ala 
    1535                 1540                 1545             


Val Leu  Lys Ala Gln Ala Asp  Val Gly Gly Ser Val  Ile Leu Leu 
    1550                 1555                 1560             


Ser Ala  Thr Leu Pro Met Lys  Gln Lys Gln Lys Leu  Leu Asp Thr 
    1565                 1570                 1575             


Tyr Gly  Leu His Thr Asp Pro  Val Glu Asn Asn Ser  Ala Tyr Pro 
    1580                 1585                 1590             


Leu Ile  Asn Trp Arg Gly Val  Asn Gly Ala Gln Arg  Phe Asp Leu 
    1595                 1600                 1605             


Leu Ala  His Pro Glu Gln Leu  Pro Pro Arg Phe Ser  Ile Gln Pro 
    1610                 1615                 1620             


Glu Pro  Ile Cys Leu Ala Asp  Met Leu Pro Asp Leu  Thr Met Leu 
    1625                 1630                 1635             


Glu Arg  Met Ile Ala Ala Ala  Asn Ala Gly Ala Gln  Val Cys Leu 
    1640                 1645                 1650             


Ile Cys  Asn Leu Val Asp Val  Ala Gln Val Cys Tyr  Gln Arg Leu 
    1655                 1660                 1665             


Lys Glu  Leu Asn Asn Thr Gln  Val Asp Ile Asp Leu  Phe His Ala 
    1670                 1675                 1680             


Arg Phe  Thr Leu Asn Asp Arg  Arg Glu Lys Glu Asn  Arg Val Ile 
    1685                 1690                 1695             


Ser Asn  Phe Gly Lys Asn Gly  Lys Arg Asn Val Gly  Arg Ile Leu 
    1700                 1705                 1710             


Val Ala  Thr Gln Val Val Glu  Gln Ser Leu Asp Val  Asp Phe Asp 
    1715                 1720                 1725             


Trp Leu  Ile Thr Gln His Cys  Pro Ala Asp Leu Leu  Phe Gln Arg 
    1730                 1735                 1740             


Leu Gly  Arg Leu His Arg His  His Arg Lys Tyr Arg  Pro Ala Gly 
    1745                 1750                 1755             


Phe Glu  Ile Pro Val Ala Thr  Ile Leu Leu Pro Asp  Gly Glu Gly 
    1760                 1765                 1770             


Tyr Gly  Arg His Glu His Ile  Tyr Ser Asn Val Arg  Val Met Trp 
    1775                 1780                 1785             


Arg Thr  Gln Gln His Ile Glu  Glu Leu Asn Gly Ala  Ser Leu Phe 
    1790                 1795                 1800             


Phe Pro  Asp Ala Tyr Arg Gln  Trp Leu Asp Ser Ile  Tyr Asp Asp 
    1805                 1810                 1815             


Ala Glu  Met Asp Glu Pro Glu  Trp Val Gly Asn Gly  Met Asp Lys 
    1820                 1825                 1830             


Phe Glu  Ser Ala Glu Cys Glu  Lys Arg Phe Lys Ala  Arg Lys Val 
    1835                 1840                 1845             


Leu Gln  Trp Ala Glu Glu Tyr  Ser Leu Gln Asp Asn  Asp Glu Thr 
    1850                 1855                 1860             


Ile Leu  Ala Val Thr Arg Asp  Gly Glu Met Ser Leu  Pro Leu Leu 
    1865                 1870                 1875             


Pro Tyr  Val Gln Thr Ser Ser  Gly Lys Gln Leu Leu  Asp Gly Gln 
    1880                 1885                 1890             


Val Tyr  Glu Asp Leu Ser His  Glu Gln Gln Tyr Glu  Ala Leu Ala 
    1895                 1900                 1905             


Leu Asn  Arg Val Asn Val Pro  Phe Thr Trp Lys Arg  Ser Phe Ser 
    1910                 1915                 1920             


Glu Val  Val Asp Glu Asp Gly  Leu Leu Trp Leu Glu  Gly Lys Gln 
    1925                 1930                 1935             


Asn Leu  Asp Gly Trp Val Trp  Gln Gly Asn Ser Ile  Val Ile Thr 
    1940                 1945                 1950             


Tyr Thr  Gly Asp Glu Gly Met  Thr Arg Val Ile Pro  Ala Asn Pro 
    1955                 1960                 1965             


Lys Ala  Asp Pro Thr Asn Arg  Ala Lys Gly Leu Glu  Ala Val Ser 
    1970                 1975                 1980             


Val Ala  Ser Met Asn Leu Leu  Ile Asp Asn Trp Ile  Pro Val Arg 
    1985                 1990                 1995             


Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile Asn Leu  Gln Ser Leu 
    2000                 2005                 2010             


Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser Leu Pro  Arg Asp Asp 
    2015                 2020                 2025             


Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val Cys Ile  Gly Gln Ile 
    2030                 2035                 2040             


Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe Arg His  Arg Ile Met 
    2045                 2050                 2055             


Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln Leu Ile  Ala Pro Trp 
    2060                 2065                 2070             


Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu His Pro  Phe Met Gln 
    2075                 2080                 2085             


Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr Pro Met  Glu Lys Leu 
    2090                 2095                 2100             


Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys Ala Phe  Val Asn Gln 
    2105                 2110                 2115             


Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly Cys Thr  Ala Ile Ala 
    2120                 2125                 2130             


Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly Phe Gly  Gly Gly Phe 
    2135                 2140                 2145             


Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val Thr Thr  Phe Val Arg 
    2150                 2155                 2160             


Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu Asn Val  Leu Thr Leu 
    2165                 2170                 2175             


Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu Ser His  Thr Glu Asn 
    2180                 2185                 2190             


Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser Asn Glu  Ser Ile Pro 
    2195                 2200                 2205             


Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu Phe Trp  Gln Pro Ala 
    2210                 2215                 2220             


His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile Gly Lys  Cys Ser Cys 
    2225                 2230                 2235             


Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr Gly Phe  Leu Lys Glu 
    2240                 2245                 2250             


Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp Pro His  Pro His Ser 
    2255                 2260                 2265             


Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu Val Glu  Glu Lys Phe 
    2270                 2275                 2280             


Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp Thr Gln  Ile Ser Arg 
    2285                 2290                 2295             


Val Val  Val Asp Lys Ile Ile  Gln Asn Glu Asn Gly  Asn Arg Val 
    2300                 2305                 2310             


Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile Ala Pro  Gln Ser Pro 
    2315                 2320                 2325             


Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn Asn Gln  Ala Ser Ile 
    2330                 2335                 2340             


Leu Glu  Arg Arg His Asp Val  Leu Met Phe Asn Gln  Gly Trp Gln 
    2345                 2350                 2355             


Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val Thr Val  Gly Leu Gly 
    2360                 2365                 2370             


Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr Thr Phe  Ala Glu Gly 
    2375                 2380                 2385             


Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly Val Ser  Val His Glu 
    2390                 2395                 2400             


Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser Glu Leu  Leu Ile Pro 
    2405                 2410                 2415             


Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln Ala Asp  Glu Val Ile 
    2420                 2425                 2430             


Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu Cys Glu  Met Leu Phe 
    2435                 2440                 2445             


Asn Gln  Ser Val Ala Pro Tyr  Ala His His Pro Lys  Leu Ile Ser 
    2450                 2455                 2460             


Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr Lys His  Leu Arg Glu 
    2465                 2470                 2475             


Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    2480                 2485             


<210>  1882
<211>  2487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas8-17aa-Cas3 fusion

<400>  1882

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            820                 825                 830         


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
        835                 840                 845             


Gly Ser Gly Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser 
    850                 855                 860                 


Arg Asp Leu Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn 
865                 870                 875                 880 


Arg Pro Asp Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn 
                885                 890                 895     


Thr Pro Glu Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val 
            900                 905                 910         


Ser Thr Ala Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln 
        915                 920                 925             


Leu Gln Val Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile 
    930                 935                 940                 


Lys Thr Ile Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile 
945                 950                 955                 960 


Lys Arg Cys Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp 
                965                 970                 975     


Leu Gln Arg Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro 
            980                 985                 990         


Ile Ser Glu Arg Pro Gln Tyr Phe  Ser Gly Asp Gly Lys  Ser Gly Lys 
        995                 1000                 1005             


Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu Thr Ile  Asn Asp Ala 
    1010                 1015                 1020             


Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly Ile Gly  Pro Ala Lys 
    1025                 1030                 1035             


Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala Pro Leu  Gly Ser Gly 
    1040                 1045                 1050             


Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn 
    1055                 1060                 1065             


Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Asn Leu 
    1070                 1075                 1080             


Leu Ile  Asp Asn Trp Ile Pro  Val Arg Pro Arg Asn  Gly Gly Lys 
    1085                 1090                 1095             


Val Gln  Ile Ile Asn Leu Gln  Ser Leu Tyr Cys Ser  Arg Asp Gln 
    1100                 1105                 1110             


Trp Arg  Leu Ser Leu Pro Arg  Asp Asp Met Glu Leu  Ala Ala Leu 
    1115                 1120                 1125             


Ala Leu  Leu Val Cys Ile Gly  Gln Ile Ile Ala Pro  Ala Lys Asp 
    1130                 1135                 1140             


Asp Val  Glu Phe Arg His Arg  Ile Met Asn Pro Leu  Thr Glu Asp 
    1145                 1150                 1155             


Glu Phe  Gln Gln Leu Ile Ala  Pro Trp Ile Asp Met  Phe Tyr Leu 
    1160                 1165                 1170             


Asn His  Ala Glu His Pro Phe  Met Gln Thr Lys Gly  Val Lys Ala 
    1175                 1180                 1185             


Asn Asp  Val Thr Pro Met Glu  Lys Leu Leu Ala Gly  Val Ser Gly 
    1190                 1195                 1200             


Ala Thr  Asn Cys Ala Phe Val  Asn Gln Pro Gly Gln  Gly Glu Ala 
    1205                 1210                 1215             


Leu Cys  Gly Gly Cys Thr Ala  Ile Ala Leu Phe Asn  Gln Ala Asn 
    1220                 1225                 1230             


Gln Ala  Pro Gly Phe Gly Gly  Gly Phe Lys Ser Gly  Leu Arg Gly 
    1235                 1240                 1245             


Gly Thr  Pro Val Thr Thr Phe  Val Arg Gly Ile Asp  Leu Arg Ser 
    1250                 1255                 1260             


Thr Val  Leu Leu Asn Val Leu  Thr Leu Pro Arg Leu  Gln Lys Gln 
    1265                 1270                 1275             


Phe Pro  Asn Glu Ser His Thr  Glu Asn Gln Pro Thr  Trp Ile Lys 
    1280                 1285                 1290             


Pro Ile  Lys Ser Asn Glu Ser  Ile Pro Ala Ser Ser  Ile Gly Phe 
    1295                 1300                 1305             


Val Arg  Gly Leu Phe Trp Gln  Pro Ala His Ile Glu  Leu Cys Asp 
    1310                 1315                 1320             


Pro Ile  Gly Ile Gly Lys Cys  Ser Cys Cys Gly Gln  Glu Ser Asn 
    1325                 1330                 1335             


Leu Arg  Tyr Thr Gly Phe Leu  Lys Glu Lys Phe Thr  Phe Thr Val 
    1340                 1345                 1350             


Asn Gly  Leu Trp Pro His Pro  His Ser Pro Cys Leu  Val Thr Val 
    1355                 1360                 1365             


Lys Lys  Gly Glu Val Glu Glu  Lys Phe Leu Ala Phe  Thr Thr Ser 
    1370                 1375                 1380             


Ala Pro  Ser Trp Thr Gln Ile  Ser Arg Val Val Val  Asp Lys Ile 
    1385                 1390                 1395             


Ile Gln  Asn Glu Asn Gly Asn  Arg Val Ala Ala Val  Val Asn Gln 
    1400                 1405                 1410             


Phe Arg  Asn Ile Ala Pro Gln  Ser Pro Leu Glu Leu  Ile Met Gly 
    1415                 1420                 1425             


Gly Tyr  Arg Asn Asn Gln Ala  Ser Ile Leu Glu Arg  Arg His Asp 
    1430                 1435                 1440             


Val Leu  Met Phe Asn Gln Gly  Trp Gln Gln Tyr Gly  Asn Val Ile 
    1445                 1450                 1455             


Asn Glu  Ile Val Thr Val Gly  Leu Gly Tyr Lys Thr  Ala Leu Arg 
    1460                 1465                 1470             


Lys Ala  Leu Tyr Thr Phe Ala  Glu Gly Phe Lys Asn  Lys Asp Phe 
    1475                 1480                 1485             


Lys Gly  Ala Gly Val Ser Val  His Glu Thr Ala Glu  Arg His Phe 
    1490                 1495                 1500             


Tyr Arg  Gln Ser Glu Leu Leu  Ile Pro Asp Val Leu  Ala Asn Val 
    1505                 1510                 1515             


Asn Phe  Ser Gln Ala Asp Glu  Val Ile Ala Asp Leu  Arg Asp Lys 
    1520                 1525                 1530             


Leu His  Gln Leu Cys Glu Met  Leu Phe Asn Gln Ser  Val Ala Pro 
    1535                 1540                 1545             


Tyr Ala  His His Pro Lys Leu  Ile Ser Thr Leu Ala  Leu Ala Arg 
    1550                 1555                 1560             


Ala Thr  Leu Tyr Lys His Leu  Arg Glu Leu Lys Pro  Gln Gly Gly 
    1565                 1570                 1575             


Pro Ser  Asn Gly Ala Asp Pro  Thr Asn Arg Ala Lys  Gly Leu Glu 
    1580                 1585                 1590             


Ala Val  Ser Val Ala Ser Met  Glu Pro Phe Lys Tyr  Ile Cys His 
    1595                 1600                 1605             


Tyr Trp  Gly Lys Ser Ser Lys  Ser Leu Thr Lys Gly  Asn Asp Ile 
    1610                 1615                 1620             


His Leu  Leu Ile Tyr His Cys  Leu Asp Val Ala Ala  Val Ala Asp 
    1625                 1630                 1635             


Cys Trp  Trp Asp Gln Ser Val  Val Leu Gln Asn Thr  Phe Cys Arg 
    1640                 1645                 1650             


Asn Glu  Met Leu Ser Lys Gln  Arg Val Lys Ala Trp  Leu Leu Phe 
    1655                 1660                 1665             


Phe Ile  Ala Leu His Asp Ile  Gly Lys Phe Asp Ile  Arg Phe Gln 
    1670                 1675                 1680             


Tyr Lys  Ser Ala Glu Ser Trp  Leu Lys Leu Asn Pro  Ala Thr Pro 
    1685                 1690                 1695             


Ser Leu  Asn Gly Pro Ser Thr  Gln Met Cys Arg Lys  Phe Asn His 
    1700                 1705                 1710             


Gly Ala  Ala Gly Leu Tyr Trp  Phe Asn Gln Asp Ser  Leu Ser Glu 
    1715                 1720                 1725             


Gln Ser  Leu Gly Asp Phe Phe  Ser Phe Phe Asp Ala  Ala Pro His 
    1730                 1735                 1740             


Pro Tyr  Glu Ser Trp Phe Pro  Trp Val Glu Ala Val  Thr Gly His 
    1745                 1750                 1755             


His Gly  Phe Ile Leu His Ser  Gln Asp Gln Asp Lys  Ser Arg Trp 
    1760                 1765                 1770             


Glu Met  Pro Ala Ser Leu Ala  Ser Tyr Ala Ala Gln  Asp Lys Gln 
    1775                 1780                 1785             


Ala Arg  Glu Glu Trp Ile Ser  Val Leu Glu Ala Leu  Phe Leu Thr 
    1790                 1795                 1800             


Pro Ala  Gly Leu Ser Ile Asn  Asp Ile Pro Pro Asp  Cys Ser Ser 
    1805                 1810                 1815             


Leu Leu  Ala Gly Phe Cys Ser  Leu Ala Asp Trp Leu  Gly Ser Trp 
    1820                 1825                 1830             


Thr Thr  Thr Asn Thr Phe Leu  Phe Asn Glu Asp Ala  Pro Ser Asp 
    1835                 1840                 1845             


Ile Asn  Ala Leu Arg Thr Tyr  Phe Gln Asp Arg Gln  Gln Asp Ala 
    1850                 1855                 1860             


Ser Arg  Val Leu Glu Leu Ser  Gly Leu Val Ser Asn  Lys Arg Cys 
    1865                 1870                 1875             


Tyr Glu  Gly Val His Ala Leu  Leu Asp Asn Gly Tyr  Gln Pro Arg 
    1880                 1885                 1890             


Gln Leu  Gln Val Leu Val Asp  Ala Leu Pro Val Ala  Pro Gly Leu 
    1895                 1900                 1905             


Thr Val  Ile Glu Ala Pro Thr  Gly Ser Gly Lys Thr  Glu Thr Ala 
    1910                 1915                 1920             


Leu Ala  Tyr Ala Trp Lys Leu  Ile Asp Gln Gln Ile  Ala Asp Ser 
    1925                 1930                 1935             


Val Ile  Phe Ala Leu Pro Thr  Gln Ala Thr Ala Asn  Ala Met Leu 
    1940                 1945                 1950             


Thr Arg  Met Glu Ala Ser Ala  Ser His Leu Phe Ser  Ser Pro Asn 
    1955                 1960                 1965             


Leu Ile  Leu Ala His Gly Asn  Ser Arg Phe Asn His  Leu Phe Gln 
    1970                 1975                 1980             


Ser Ile  Lys Ser Arg Ala Ile  Thr Glu Gln Gly Gln  Glu Glu Ala 
    1985                 1990                 1995             


Trp Val  Gln Cys Cys Gln Trp  Leu Ser Gln Ser Asn  Lys Lys Val 
    2000                 2005                 2010             


Phe Leu  Gly Gln Ile Gly Val  Cys Thr Ile Asp Gln  Val Leu Ile 
    2015                 2020                 2025             


Ser Val  Leu Pro Val Lys His  Arg Phe Ile Arg Gly  Leu Gly Ile 
    2030                 2035                 2040             


Gly Arg  Ser Val Leu Ile Val  Asp Glu Val His Ala  Tyr Asp Thr 
    2045                 2050                 2055             


Tyr Met  Asn Gly Leu Leu Glu  Ala Val Leu Lys Ala  Gln Ala Asp 
    2060                 2065                 2070             


Val Gly  Gly Ser Val Ile Leu  Leu Ser Ala Thr Leu  Pro Met Lys 
    2075                 2080                 2085             


Gln Lys  Gln Lys Leu Leu Asp  Thr Tyr Gly Leu His  Thr Asp Pro 
    2090                 2095                 2100             


Val Glu  Asn Asn Ser Ala Tyr  Pro Leu Ile Asn Trp  Arg Gly Val 
    2105                 2110                 2115             


Asn Gly  Ala Gln Arg Phe Asp  Leu Leu Ala His Pro  Glu Gln Leu 
    2120                 2125                 2130             


Pro Pro  Arg Phe Ser Ile Gln  Pro Glu Pro Ile Cys  Leu Ala Asp 
    2135                 2140                 2145             


Met Leu  Pro Asp Leu Thr Met  Leu Glu Arg Met Ile  Ala Ala Ala 
    2150                 2155                 2160             


Asn Ala  Gly Ala Gln Val Cys  Leu Ile Cys Asn Leu  Val Asp Val 
    2165                 2170                 2175             


Ala Gln  Val Cys Tyr Gln Arg  Leu Lys Glu Leu Asn  Asn Thr Gln 
    2180                 2185                 2190             


Val Asp  Ile Asp Leu Phe His  Ala Arg Phe Thr Leu  Asn Asp Arg 
    2195                 2200                 2205             


Arg Glu  Lys Glu Asn Arg Val  Ile Ser Asn Phe Gly  Lys Asn Gly 
    2210                 2215                 2220             


Lys Arg  Asn Val Gly Arg Ile  Leu Val Ala Thr Gln  Val Val Glu 
    2225                 2230                 2235             


Gln Ser  Leu Asp Val Asp Phe  Asp Trp Leu Ile Thr  Gln His Cys 
    2240                 2245                 2250             


Pro Ala  Asp Leu Leu Phe Gln  Arg Leu Gly Arg Leu  His Arg His 
    2255                 2260                 2265             


His Arg  Lys Tyr Arg Pro Ala  Gly Phe Glu Ile Pro  Val Ala Thr 
    2270                 2275                 2280             


Ile Leu  Leu Pro Asp Gly Glu  Gly Tyr Gly Arg His  Glu His Ile 
    2285                 2290                 2295             


Tyr Ser  Asn Val Arg Val Met  Trp Arg Thr Gln Gln  His Ile Glu 
    2300                 2305                 2310             


Glu Leu  Asn Gly Ala Ser Leu  Phe Phe Pro Asp Ala  Tyr Arg Gln 
    2315                 2320                 2325             


Trp Leu  Asp Ser Ile Tyr Asp  Asp Ala Glu Met Asp  Glu Pro Glu 
    2330                 2335                 2340             


Trp Val  Gly Asn Gly Met Asp  Lys Phe Glu Ser Ala  Glu Cys Glu 
    2345                 2350                 2355             


Lys Arg  Phe Lys Ala Arg Lys  Val Leu Gln Trp Ala  Glu Glu Tyr 
    2360                 2365                 2370             


Ser Leu  Gln Asp Asn Asp Glu  Thr Ile Leu Ala Val  Thr Arg Asp 
    2375                 2380                 2385             


Gly Glu  Met Ser Leu Pro Leu  Leu Pro Tyr Val Gln  Thr Ser Ser 
    2390                 2395                 2400             


Gly Lys  Gln Leu Leu Asp Gly  Gln Val Tyr Glu Asp  Leu Ser His 
    2405                 2410                 2415             


Glu Gln  Gln Tyr Glu Ala Leu  Ala Leu Asn Arg Val  Asn Val Pro 
    2420                 2425                 2430             


Phe Thr  Trp Lys Arg Ser Phe  Ser Glu Val Val Asp  Glu Asp Gly 
    2435                 2440                 2445             


Leu Leu  Trp Leu Glu Gly Lys  Gln Asn Leu Asp Gly  Trp Val Trp 
    2450                 2455                 2460             


Gln Gly  Asn Ser Ile Val Ile  Thr Tyr Thr Gly Asp  Glu Gly Met 
    2465                 2470                 2475             


Thr Arg  Val Ile Pro Ala Asn  Pro Lys 
    2480                 2485         


<210>  1883
<211>  2488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas3-17aa-Cas5 fusion

<400>  1883

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly 
        595                 600                 605             


Lys Ser Ser Lys Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile 
    610                 615                 620                 


Tyr His Cys Leu Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln 
625                 630                 635                 640 


Ser Val Val Leu Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys 
                645                 650                 655     


Gln Arg Val Lys Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile 
            660                 665                 670         


Gly Lys Phe Asp Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu 
        675                 680                 685             


Lys Leu Asn Pro Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met 
    690                 695                 700                 


Cys Arg Lys Phe Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln 
705                 710                 715                 720 


Asp Ser Leu Ser Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp 
                725                 730                 735     


Ala Ala Pro His Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val 
            740                 745                 750         


Thr Gly His His Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser 
        755                 760                 765             


Arg Trp Glu Met Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys 
    770                 775                 780                 


Gln Ala Arg Glu Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr 
785                 790                 795                 800 


Pro Ala Gly Leu Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu 
                805                 810                 815     


Leu Ala Gly Phe Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr 
            820                 825                 830         


Thr Asn Thr Phe Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala 
        835                 840                 845             


Leu Arg Thr Tyr Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu 
    850                 855                 860                 


Glu Leu Ser Gly Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His 
865                 870                 875                 880 


Ala Leu Leu Asp Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val 
                885                 890                 895     


Asp Ala Leu Pro Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr 
            900                 905                 910         


Gly Ser Gly Lys Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile 
        915                 920                 925             


Asp Gln Gln Ile Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala 
    930                 935                 940                 


Thr Ala Asn Ala Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu 
945                 950                 955                 960 


Phe Ser Ser Pro Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn 
                965                 970                 975     


His Leu Phe Gln Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln 
            980                 985                 990         


Glu Glu Ala Trp Val Gln Cys Cys  Gln Trp Leu Ser Gln  Ser Asn Lys 
        995                 1000                 1005             


Lys Val  Phe Leu Gly Gln Ile  Gly Val Cys Thr Ile  Asp Gln Val 
    1010                 1015                 1020             


Leu Ile  Ser Val Leu Pro Val  Lys His Arg Phe Ile  Arg Gly Leu 
    1025                 1030                 1035             


Gly Ile  Gly Arg Ser Val Leu  Ile Val Asp Glu Val  His Ala Tyr 
    1040                 1045                 1050             


Asp Thr  Tyr Met Asn Gly Leu  Leu Glu Ala Val Leu  Lys Ala Gln 
    1055                 1060                 1065             


Ala Asp  Val Gly Gly Ser Val  Ile Leu Leu Ser Ala  Thr Leu Pro 
    1070                 1075                 1080             


Met Lys  Gln Lys Gln Lys Leu  Leu Asp Thr Tyr Gly  Leu His Thr 
    1085                 1090                 1095             


Asp Pro  Val Glu Asn Asn Ser  Ala Tyr Pro Leu Ile  Asn Trp Arg 
    1100                 1105                 1110             


Gly Val  Asn Gly Ala Gln Arg  Phe Asp Leu Leu Ala  His Pro Glu 
    1115                 1120                 1125             


Gln Leu  Pro Pro Arg Phe Ser  Ile Gln Pro Glu Pro  Ile Cys Leu 
    1130                 1135                 1140             


Ala Asp  Met Leu Pro Asp Leu  Thr Met Leu Glu Arg  Met Ile Ala 
    1145                 1150                 1155             


Ala Ala  Asn Ala Gly Ala Gln  Val Cys Leu Ile Cys  Asn Leu Val 
    1160                 1165                 1170             


Asp Val  Ala Gln Val Cys Tyr  Gln Arg Leu Lys Glu  Leu Asn Asn 
    1175                 1180                 1185             


Thr Gln  Val Asp Ile Asp Leu  Phe His Ala Arg Phe  Thr Leu Asn 
    1190                 1195                 1200             


Asp Arg  Arg Glu Lys Glu Asn  Arg Val Ile Ser Asn  Phe Gly Lys 
    1205                 1210                 1215             


Asn Gly  Lys Arg Asn Val Gly  Arg Ile Leu Val Ala  Thr Gln Val 
    1220                 1225                 1230             


Val Glu  Gln Ser Leu Asp Val  Asp Phe Asp Trp Leu  Ile Thr Gln 
    1235                 1240                 1245             


His Cys  Pro Ala Asp Leu Leu  Phe Gln Arg Leu Gly  Arg Leu His 
    1250                 1255                 1260             


Arg His  His Arg Lys Tyr Arg  Pro Ala Gly Phe Glu  Ile Pro Val 
    1265                 1270                 1275             


Ala Thr  Ile Leu Leu Pro Asp  Gly Glu Gly Tyr Gly  Arg His Glu 
    1280                 1285                 1290             


His Ile  Tyr Ser Asn Val Arg  Val Met Trp Arg Thr  Gln Gln His 
    1295                 1300                 1305             


Ile Glu  Glu Leu Asn Gly Ala  Ser Leu Phe Phe Pro  Asp Ala Tyr 
    1310                 1315                 1320             


Arg Gln  Trp Leu Asp Ser Ile  Tyr Asp Asp Ala Glu  Met Asp Glu 
    1325                 1330                 1335             


Pro Glu  Trp Val Gly Asn Gly  Met Asp Lys Phe Glu  Ser Ala Glu 
    1340                 1345                 1350             


Cys Glu  Lys Arg Phe Lys Ala  Arg Lys Val Leu Gln  Trp Ala Glu 
    1355                 1360                 1365             


Glu Tyr  Ser Leu Gln Asp Asn  Asp Glu Thr Ile Leu  Ala Val Thr 
    1370                 1375                 1380             


Arg Asp  Gly Glu Met Ser Leu  Pro Leu Leu Pro Tyr  Val Gln Thr 
    1385                 1390                 1395             


Ser Ser  Gly Lys Gln Leu Leu  Asp Gly Gln Val Tyr  Glu Asp Leu 
    1400                 1405                 1410             


Ser His  Glu Gln Gln Tyr Glu  Ala Leu Ala Leu Asn  Arg Val Asn 
    1415                 1420                 1425             


Val Pro  Phe Thr Trp Lys Arg  Ser Phe Ser Glu Val  Val Asp Glu 
    1430                 1435                 1440             


Asp Gly  Leu Leu Trp Leu Glu  Gly Lys Gln Asn Leu  Asp Gly Trp 
    1445                 1450                 1455             


Val Trp  Gln Gly Asn Ser Ile  Val Ile Thr Tyr Thr  Gly Asp Glu 
    1460                 1465                 1470             


Gly Met  Thr Arg Val Ile Pro  Ala Asn Pro Lys Ala  Asp Pro Thr 
    1475                 1480                 1485             


Asn Arg  Ala Lys Gly Leu Glu  Ala Val Ser Val Ala  Ser Met Arg 
    1490                 1495                 1500             


Ser Tyr  Leu Ile Leu Arg Leu  Ala Gly Pro Met Gln  Ala Trp Gly 
    1505                 1510                 1515             


Gln Pro  Thr Phe Glu Gly Thr  Arg Pro Thr Gly Arg  Phe Pro Thr 
    1520                 1525                 1530             


Arg Ser  Gly Leu Leu Gly Leu  Leu Gly Ala Cys Leu  Gly Ile Gln 
    1535                 1540                 1545             


Arg Asp  Asp Thr Ser Ser Leu  Gln Ala Leu Ser Glu  Ser Val Gln 
    1550                 1555                 1560             


Phe Ala  Val Arg Cys Asp Glu  Leu Ile Leu Asp Asp  Arg Arg Val 
    1565                 1570                 1575             


Ser Val  Thr Gly Leu Arg Asp  Tyr His Thr Val Leu  Gly Ala Arg 
    1580                 1585                 1590             


Glu Asp  Tyr Arg Gly Leu Lys  Ser His Glu Thr Ile  Gln Thr Trp 
    1595                 1600                 1605             


Arg Glu  Tyr Leu Cys Asp Ala  Ser Phe Thr Val Ala  Leu Trp Leu 
    1610                 1615                 1620             


Thr Pro  His Ala Thr Met Val  Ile Ser Glu Leu Glu  Lys Ala Val 
    1625                 1630                 1635             


Leu Lys  Pro Arg Tyr Thr Pro  Tyr Leu Gly Arg Arg  Ser Cys Pro 
    1640                 1645                 1650             


Leu Thr  His Pro Leu Phe Leu  Gly Thr Cys Gln Ala  Ser Asp Pro 
    1655                 1660                 1665             


Gln Lys  Ala Leu Leu Asn Tyr  Glu Pro Val Gly Gly  Asp Ile Tyr 
    1670                 1675                 1680             


Ser Glu  Glu Ser Val Thr Gly  His His Leu Lys Phe  Thr Ala Arg 
    1685                 1690                 1695             


Asp Glu  Pro Met Ile Thr Leu  Pro Arg Gln Phe Ala  Ser Arg Glu 
    1700                 1705                 1710             


Trp Tyr  Val Ile Lys Gly Gly  Met Asp Val Ser Gln  Gly Ser Gly 
    1715                 1720                 1725             


Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn 
    1730                 1735                 1740             


Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Met Tyr 
    1745                 1750                 1755             


Leu Ser  Lys Val Ile Ile Ala  Arg Ala Trp Ser Arg  Asp Leu Tyr 
    1760                 1765                 1770             


Gln Leu  His Gln Gly Leu Trp  His Leu Phe Pro Asn  Arg Pro Asp 
    1775                 1780                 1785             


Ala Ala  Arg Asp Phe Leu Phe  His Val Glu Lys Arg  Asn Thr Pro 
    1790                 1795                 1800             


Glu Gly  Cys His Val Leu Leu  Gln Ser Ala Gln Met  Pro Val Ser 
    1805                 1810                 1815             


Thr Ala  Val Ala Thr Val Ile  Lys Thr Lys Gln Val  Glu Phe Gln 
    1820                 1825                 1830             


Leu Gln  Val Gly Val Pro Leu  Tyr Phe Arg Leu Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ile Lys  Thr Ile Leu Asp Asn  Gln Lys Arg Leu Asp  Ser Lys Gly 
    1850                 1855                 1860             


Asn Ile  Lys Arg Cys Arg Val  Pro Leu Ile Lys Glu  Ala Glu Gln 
    1865                 1870                 1875             


Ile Ala  Trp Leu Gln Arg Lys  Leu Gly Asn Ala Ala  Arg Val Glu 
    1880                 1885                 1890             


Asp Val  His Pro Ile Ser Glu  Arg Pro Gln Tyr Phe  Ser Gly Asp 
    1895                 1900                 1905             


Gly Lys  Ser Gly Lys Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu 
    1910                 1915                 1920             


Thr Ile  Asn Asp Ala Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly 
    1925                 1930                 1935             


Ile Gly  Pro Ala Lys Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala 
    1940                 1945                 1950             


Pro Leu  Gly Ser Gly Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly 
    1955                 1960                 1965             


Asp Val  Glu Glu Asn Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val 
    1970                 1975                 1980             


Gly Ser  Gly Met Asn Leu Leu  Ile Asp Asn Trp Ile  Pro Val Arg 
    1985                 1990                 1995             


Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile Asn Leu  Gln Ser Leu 
    2000                 2005                 2010             


Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser Leu Pro  Arg Asp Asp 
    2015                 2020                 2025             


Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val Cys Ile  Gly Gln Ile 
    2030                 2035                 2040             


Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe Arg His  Arg Ile Met 
    2045                 2050                 2055             


Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln Leu Ile  Ala Pro Trp 
    2060                 2065                 2070             


Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu His Pro  Phe Met Gln 
    2075                 2080                 2085             


Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr Pro Met  Glu Lys Leu 
    2090                 2095                 2100             


Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys Ala Phe  Val Asn Gln 
    2105                 2110                 2115             


Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly Cys Thr  Ala Ile Ala 
    2120                 2125                 2130             


Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly Phe Gly  Gly Gly Phe 
    2135                 2140                 2145             


Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val Thr Thr  Phe Val Arg 
    2150                 2155                 2160             


Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu Asn Val  Leu Thr Leu 
    2165                 2170                 2175             


Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu Ser His  Thr Glu Asn 
    2180                 2185                 2190             


Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser Asn Glu  Ser Ile Pro 
    2195                 2200                 2205             


Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu Phe Trp  Gln Pro Ala 
    2210                 2215                 2220             


His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile Gly Lys  Cys Ser Cys 
    2225                 2230                 2235             


Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr Gly Phe  Leu Lys Glu 
    2240                 2245                 2250             


Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp Pro His  Pro His Ser 
    2255                 2260                 2265             


Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu Val Glu  Glu Lys Phe 
    2270                 2275                 2280             


Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp Thr Gln  Ile Ser Arg 
    2285                 2290                 2295             


Val Val  Val Asp Lys Ile Ile  Gln Asn Glu Asn Gly  Asn Arg Val 
    2300                 2305                 2310             


Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile Ala Pro  Gln Ser Pro 
    2315                 2320                 2325             


Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn Asn Gln  Ala Ser Ile 
    2330                 2335                 2340             


Leu Glu  Arg Arg His Asp Val  Leu Met Phe Asn Gln  Gly Trp Gln 
    2345                 2350                 2355             


Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val Thr Val  Gly Leu Gly 
    2360                 2365                 2370             


Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr Thr Phe  Ala Glu Gly 
    2375                 2380                 2385             


Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly Val Ser  Val His Glu 
    2390                 2395                 2400             


Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser Glu Leu  Leu Ile Pro 
    2405                 2410                 2415             


Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln Ala Asp  Glu Val Ile 
    2420                 2425                 2430             


Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu Cys Glu  Met Leu Phe 
    2435                 2440                 2445             


Asn Gln  Ser Val Ala Pro Tyr  Ala His His Pro Lys  Leu Ile Ser 
    2450                 2455                 2460             


Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr Lys His  Leu Arg Glu 
    2465                 2470                 2475             


Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    2480                 2485             


<210>  1884
<211>  2488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas5-17aa-Cas3 fusion

<400>  1884

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Ala Asp Pro Thr Asn Arg Ala Lys Gly Leu Glu Ala 
            820                 825                 830         


Val Ser Val Ala Ser Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp 
        835                 840                 845             


Gly Lys Ser Ser Lys Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu 
    850                 855                 860                 


Ile Tyr His Cys Leu Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp 
865                 870                 875                 880 


Gln Ser Val Val Leu Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser 
                885                 890                 895     


Lys Gln Arg Val Lys Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp 
            900                 905                 910         


Ile Gly Lys Phe Asp Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp 
        915                 920                 925             


Leu Lys Leu Asn Pro Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln 
    930                 935                 940                 


Met Cys Arg Lys Phe Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn 
945                 950                 955                 960 


Gln Asp Ser Leu Ser Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe 
                965                 970                 975     


Asp Ala Ala Pro His Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala 
            980                 985                 990         


Val Thr Gly His His Gly Phe Ile  Leu His Ser Gln Asp  Gln Asp Lys 
        995                 1000                 1005             


Ser Arg  Trp Glu Met Pro Ala  Ser Leu Ala Ser Tyr  Ala Ala Gln 
    1010                 1015                 1020             


Asp Lys  Gln Ala Arg Glu Glu  Trp Ile Ser Val Leu  Glu Ala Leu 
    1025                 1030                 1035             


Phe Leu  Thr Pro Ala Gly Leu  Ser Ile Asn Asp Ile  Pro Pro Asp 
    1040                 1045                 1050             


Cys Ser  Ser Leu Leu Ala Gly  Phe Cys Ser Leu Ala  Asp Trp Leu 
    1055                 1060                 1065             


Gly Ser  Trp Thr Thr Thr Asn  Thr Phe Leu Phe Asn  Glu Asp Ala 
    1070                 1075                 1080             


Pro Ser  Asp Ile Asn Ala Leu  Arg Thr Tyr Phe Gln  Asp Arg Gln 
    1085                 1090                 1095             


Gln Asp  Ala Ser Arg Val Leu  Glu Leu Ser Gly Leu  Val Ser Asn 
    1100                 1105                 1110             


Lys Arg  Cys Tyr Glu Gly Val  His Ala Leu Leu Asp  Asn Gly Tyr 
    1115                 1120                 1125             


Gln Pro  Arg Gln Leu Gln Val  Leu Val Asp Ala Leu  Pro Val Ala 
    1130                 1135                 1140             


Pro Gly  Leu Thr Val Ile Glu  Ala Pro Thr Gly Ser  Gly Lys Thr 
    1145                 1150                 1155             


Glu Thr  Ala Leu Ala Tyr Ala  Trp Lys Leu Ile Asp  Gln Gln Ile 
    1160                 1165                 1170             


Ala Asp  Ser Val Ile Phe Ala  Leu Pro Thr Gln Ala  Thr Ala Asn 
    1175                 1180                 1185             


Ala Met  Leu Thr Arg Met Glu  Ala Ser Ala Ser His  Leu Phe Ser 
    1190                 1195                 1200             


Ser Pro  Asn Leu Ile Leu Ala  His Gly Asn Ser Arg  Phe Asn His 
    1205                 1210                 1215             


Leu Phe  Gln Ser Ile Lys Ser  Arg Ala Ile Thr Glu  Gln Gly Gln 
    1220                 1225                 1230             


Glu Glu  Ala Trp Val Gln Cys  Cys Gln Trp Leu Ser  Gln Ser Asn 
    1235                 1240                 1245             


Lys Lys  Val Phe Leu Gly Gln  Ile Gly Val Cys Thr  Ile Asp Gln 
    1250                 1255                 1260             


Val Leu  Ile Ser Val Leu Pro  Val Lys His Arg Phe  Ile Arg Gly 
    1265                 1270                 1275             


Leu Gly  Ile Gly Arg Ser Val  Leu Ile Val Asp Glu  Val His Ala 
    1280                 1285                 1290             


Tyr Asp  Thr Tyr Met Asn Gly  Leu Leu Glu Ala Val  Leu Lys Ala 
    1295                 1300                 1305             


Gln Ala  Asp Val Gly Gly Ser  Val Ile Leu Leu Ser  Ala Thr Leu 
    1310                 1315                 1320             


Pro Met  Lys Gln Lys Gln Lys  Leu Leu Asp Thr Tyr  Gly Leu His 
    1325                 1330                 1335             


Thr Asp  Pro Val Glu Asn Asn  Ser Ala Tyr Pro Leu  Ile Asn Trp 
    1340                 1345                 1350             


Arg Gly  Val Asn Gly Ala Gln  Arg Phe Asp Leu Leu  Ala His Pro 
    1355                 1360                 1365             


Glu Gln  Leu Pro Pro Arg Phe  Ser Ile Gln Pro Glu  Pro Ile Cys 
    1370                 1375                 1380             


Leu Ala  Asp Met Leu Pro Asp  Leu Thr Met Leu Glu  Arg Met Ile 
    1385                 1390                 1395             


Ala Ala  Ala Asn Ala Gly Ala  Gln Val Cys Leu Ile  Cys Asn Leu 
    1400                 1405                 1410             


Val Asp  Val Ala Gln Val Cys  Tyr Gln Arg Leu Lys  Glu Leu Asn 
    1415                 1420                 1425             


Asn Thr  Gln Val Asp Ile Asp  Leu Phe His Ala Arg  Phe Thr Leu 
    1430                 1435                 1440             


Asn Asp  Arg Arg Glu Lys Glu  Asn Arg Val Ile Ser  Asn Phe Gly 
    1445                 1450                 1455             


Lys Asn  Gly Lys Arg Asn Val  Gly Arg Ile Leu Val  Ala Thr Gln 
    1460                 1465                 1470             


Val Val  Glu Gln Ser Leu Asp  Val Asp Phe Asp Trp  Leu Ile Thr 
    1475                 1480                 1485             


Gln His  Cys Pro Ala Asp Leu  Leu Phe Gln Arg Leu  Gly Arg Leu 
    1490                 1495                 1500             


His Arg  His His Arg Lys Tyr  Arg Pro Ala Gly Phe  Glu Ile Pro 
    1505                 1510                 1515             


Val Ala  Thr Ile Leu Leu Pro  Asp Gly Glu Gly Tyr  Gly Arg His 
    1520                 1525                 1530             


Glu His  Ile Tyr Ser Asn Val  Arg Val Met Trp Arg  Thr Gln Gln 
    1535                 1540                 1545             


His Ile  Glu Glu Leu Asn Gly  Ala Ser Leu Phe Phe  Pro Asp Ala 
    1550                 1555                 1560             


Tyr Arg  Gln Trp Leu Asp Ser  Ile Tyr Asp Asp Ala  Glu Met Asp 
    1565                 1570                 1575             


Glu Pro  Glu Trp Val Gly Asn  Gly Met Asp Lys Phe  Glu Ser Ala 
    1580                 1585                 1590             


Glu Cys  Glu Lys Arg Phe Lys  Ala Arg Lys Val Leu  Gln Trp Ala 
    1595                 1600                 1605             


Glu Glu  Tyr Ser Leu Gln Asp  Asn Asp Glu Thr Ile  Leu Ala Val 
    1610                 1615                 1620             


Thr Arg  Asp Gly Glu Met Ser  Leu Pro Leu Leu Pro  Tyr Val Gln 
    1625                 1630                 1635             


Thr Ser  Ser Gly Lys Gln Leu  Leu Asp Gly Gln Val  Tyr Glu Asp 
    1640                 1645                 1650             


Leu Ser  His Glu Gln Gln Tyr  Glu Ala Leu Ala Leu  Asn Arg Val 
    1655                 1660                 1665             


Asn Val  Pro Phe Thr Trp Lys  Arg Ser Phe Ser Glu  Val Val Asp 
    1670                 1675                 1680             


Glu Asp  Gly Leu Leu Trp Leu  Glu Gly Lys Gln Asn  Leu Asp Gly 
    1685                 1690                 1695             


Trp Val  Trp Gln Gly Asn Ser  Ile Val Ile Thr Tyr  Thr Gly Asp 
    1700                 1705                 1710             


Glu Gly  Met Thr Arg Val Ile  Pro Ala Asn Pro Lys  Gly Ser Gly 
    1715                 1720                 1725             


Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn 
    1730                 1735                 1740             


Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Met Tyr 
    1745                 1750                 1755             


Leu Ser  Lys Val Ile Ile Ala  Arg Ala Trp Ser Arg  Asp Leu Tyr 
    1760                 1765                 1770             


Gln Leu  His Gln Gly Leu Trp  His Leu Phe Pro Asn  Arg Pro Asp 
    1775                 1780                 1785             


Ala Ala  Arg Asp Phe Leu Phe  His Val Glu Lys Arg  Asn Thr Pro 
    1790                 1795                 1800             


Glu Gly  Cys His Val Leu Leu  Gln Ser Ala Gln Met  Pro Val Ser 
    1805                 1810                 1815             


Thr Ala  Val Ala Thr Val Ile  Lys Thr Lys Gln Val  Glu Phe Gln 
    1820                 1825                 1830             


Leu Gln  Val Gly Val Pro Leu  Tyr Phe Arg Leu Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ile Lys  Thr Ile Leu Asp Asn  Gln Lys Arg Leu Asp  Ser Lys Gly 
    1850                 1855                 1860             


Asn Ile  Lys Arg Cys Arg Val  Pro Leu Ile Lys Glu  Ala Glu Gln 
    1865                 1870                 1875             


Ile Ala  Trp Leu Gln Arg Lys  Leu Gly Asn Ala Ala  Arg Val Glu 
    1880                 1885                 1890             


Asp Val  His Pro Ile Ser Glu  Arg Pro Gln Tyr Phe  Ser Gly Asp 
    1895                 1900                 1905             


Gly Lys  Ser Gly Lys Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu 
    1910                 1915                 1920             


Thr Ile  Asn Asp Ala Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly 
    1925                 1930                 1935             


Ile Gly  Pro Ala Lys Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala 
    1940                 1945                 1950             


Pro Leu  Gly Ser Gly Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly 
    1955                 1960                 1965             


Asp Val  Glu Glu Asn Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val 
    1970                 1975                 1980             


Gly Ser  Gly Met Asn Leu Leu  Ile Asp Asn Trp Ile  Pro Val Arg 
    1985                 1990                 1995             


Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile Asn Leu  Gln Ser Leu 
    2000                 2005                 2010             


Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser Leu Pro  Arg Asp Asp 
    2015                 2020                 2025             


Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val Cys Ile  Gly Gln Ile 
    2030                 2035                 2040             


Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe Arg His  Arg Ile Met 
    2045                 2050                 2055             


Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln Leu Ile  Ala Pro Trp 
    2060                 2065                 2070             


Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu His Pro  Phe Met Gln 
    2075                 2080                 2085             


Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr Pro Met  Glu Lys Leu 
    2090                 2095                 2100             


Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys Ala Phe  Val Asn Gln 
    2105                 2110                 2115             


Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly Cys Thr  Ala Ile Ala 
    2120                 2125                 2130             


Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly Phe Gly  Gly Gly Phe 
    2135                 2140                 2145             


Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val Thr Thr  Phe Val Arg 
    2150                 2155                 2160             


Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu Asn Val  Leu Thr Leu 
    2165                 2170                 2175             


Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu Ser His  Thr Glu Asn 
    2180                 2185                 2190             


Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser Asn Glu  Ser Ile Pro 
    2195                 2200                 2205             


Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu Phe Trp  Gln Pro Ala 
    2210                 2215                 2220             


His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile Gly Lys  Cys Ser Cys 
    2225                 2230                 2235             


Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr Gly Phe  Leu Lys Glu 
    2240                 2245                 2250             


Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp Pro His  Pro His Ser 
    2255                 2260                 2265             


Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu Val Glu  Glu Lys Phe 
    2270                 2275                 2280             


Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp Thr Gln  Ile Ser Arg 
    2285                 2290                 2295             


Val Val  Val Asp Lys Ile Ile  Gln Asn Glu Asn Gly  Asn Arg Val 
    2300                 2305                 2310             


Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile Ala Pro  Gln Ser Pro 
    2315                 2320                 2325             


Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn Asn Gln  Ala Ser Ile 
    2330                 2335                 2340             


Leu Glu  Arg Arg His Asp Val  Leu Met Phe Asn Gln  Gly Trp Gln 
    2345                 2350                 2355             


Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val Thr Val  Gly Leu Gly 
    2360                 2365                 2370             


Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr Thr Phe  Ala Glu Gly 
    2375                 2380                 2385             


Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly Val Ser  Val His Glu 
    2390                 2395                 2400             


Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser Glu Leu  Leu Ile Pro 
    2405                 2410                 2415             


Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln Ala Asp  Glu Val Ile 
    2420                 2425                 2430             


Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu Cys Glu  Met Leu Phe 
    2435                 2440                 2445             


Asn Gln  Ser Val Ala Pro Tyr  Ala His His Pro Lys  Leu Ile Ser 
    2450                 2455                 2460             


Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr Lys His  Leu Arg Glu 
    2465                 2470                 2475             


Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    2480                 2485             


<210>  1885
<211>  2488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas3-17aa-Cas6 fusion

<400>  1885

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            820                 825                 830         


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
        835                 840                 845             


Gly Ser Gly Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys 
    850                 855                 860                 


Ser Ser Lys Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr 
865                 870                 875                 880 


His Cys Leu Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser 
                885                 890                 895     


Val Val Leu Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln 
            900                 905                 910         


Arg Val Lys Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly 
        915                 920                 925             


Lys Phe Asp Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys 
    930                 935                 940                 


Leu Asn Pro Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys 
945                 950                 955                 960 


Arg Lys Phe Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp 
                965                 970                 975     


Ser Leu Ser Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala 
            980                 985                 990         


Ala Pro His Pro Tyr Glu Ser Trp  Phe Pro Trp Val Glu  Ala Val Thr 
        995                 1000                 1005             


Gly His  His Gly Phe Ile Leu  His Ser Gln Asp Gln  Asp Lys Ser 
    1010                 1015                 1020             


Arg Trp  Glu Met Pro Ala Ser  Leu Ala Ser Tyr Ala  Ala Gln Asp 
    1025                 1030                 1035             


Lys Gln  Ala Arg Glu Glu Trp  Ile Ser Val Leu Glu  Ala Leu Phe 
    1040                 1045                 1050             


Leu Thr  Pro Ala Gly Leu Ser  Ile Asn Asp Ile Pro  Pro Asp Cys 
    1055                 1060                 1065             


Ser Ser  Leu Leu Ala Gly Phe  Cys Ser Leu Ala Asp  Trp Leu Gly 
    1070                 1075                 1080             


Ser Trp  Thr Thr Thr Asn Thr  Phe Leu Phe Asn Glu  Asp Ala Pro 
    1085                 1090                 1095             


Ser Asp  Ile Asn Ala Leu Arg  Thr Tyr Phe Gln Asp  Arg Gln Gln 
    1100                 1105                 1110             


Asp Ala  Ser Arg Val Leu Glu  Leu Ser Gly Leu Val  Ser Asn Lys 
    1115                 1120                 1125             


Arg Cys  Tyr Glu Gly Val His  Ala Leu Leu Asp Asn  Gly Tyr Gln 
    1130                 1135                 1140             


Pro Arg  Gln Leu Gln Val Leu  Val Asp Ala Leu Pro  Val Ala Pro 
    1145                 1150                 1155             


Gly Leu  Thr Val Ile Glu Ala  Pro Thr Gly Ser Gly  Lys Thr Glu 
    1160                 1165                 1170             


Thr Ala  Leu Ala Tyr Ala Trp  Lys Leu Ile Asp Gln  Gln Ile Ala 
    1175                 1180                 1185             


Asp Ser  Val Ile Phe Ala Leu  Pro Thr Gln Ala Thr  Ala Asn Ala 
    1190                 1195                 1200             


Met Leu  Thr Arg Met Glu Ala  Ser Ala Ser His Leu  Phe Ser Ser 
    1205                 1210                 1215             


Pro Asn  Leu Ile Leu Ala His  Gly Asn Ser Arg Phe  Asn His Leu 
    1220                 1225                 1230             


Phe Gln  Ser Ile Lys Ser Arg  Ala Ile Thr Glu Gln  Gly Gln Glu 
    1235                 1240                 1245             


Glu Ala  Trp Val Gln Cys Cys  Gln Trp Leu Ser Gln  Ser Asn Lys 
    1250                 1255                 1260             


Lys Val  Phe Leu Gly Gln Ile  Gly Val Cys Thr Ile  Asp Gln Val 
    1265                 1270                 1275             


Leu Ile  Ser Val Leu Pro Val  Lys His Arg Phe Ile  Arg Gly Leu 
    1280                 1285                 1290             


Gly Ile  Gly Arg Ser Val Leu  Ile Val Asp Glu Val  His Ala Tyr 
    1295                 1300                 1305             


Asp Thr  Tyr Met Asn Gly Leu  Leu Glu Ala Val Leu  Lys Ala Gln 
    1310                 1315                 1320             


Ala Asp  Val Gly Gly Ser Val  Ile Leu Leu Ser Ala  Thr Leu Pro 
    1325                 1330                 1335             


Met Lys  Gln Lys Gln Lys Leu  Leu Asp Thr Tyr Gly  Leu His Thr 
    1340                 1345                 1350             


Asp Pro  Val Glu Asn Asn Ser  Ala Tyr Pro Leu Ile  Asn Trp Arg 
    1355                 1360                 1365             


Gly Val  Asn Gly Ala Gln Arg  Phe Asp Leu Leu Ala  His Pro Glu 
    1370                 1375                 1380             


Gln Leu  Pro Pro Arg Phe Ser  Ile Gln Pro Glu Pro  Ile Cys Leu 
    1385                 1390                 1395             


Ala Asp  Met Leu Pro Asp Leu  Thr Met Leu Glu Arg  Met Ile Ala 
    1400                 1405                 1410             


Ala Ala  Asn Ala Gly Ala Gln  Val Cys Leu Ile Cys  Asn Leu Val 
    1415                 1420                 1425             


Asp Val  Ala Gln Val Cys Tyr  Gln Arg Leu Lys Glu  Leu Asn Asn 
    1430                 1435                 1440             


Thr Gln  Val Asp Ile Asp Leu  Phe His Ala Arg Phe  Thr Leu Asn 
    1445                 1450                 1455             


Asp Arg  Arg Glu Lys Glu Asn  Arg Val Ile Ser Asn  Phe Gly Lys 
    1460                 1465                 1470             


Asn Gly  Lys Arg Asn Val Gly  Arg Ile Leu Val Ala  Thr Gln Val 
    1475                 1480                 1485             


Val Glu  Gln Ser Leu Asp Val  Asp Phe Asp Trp Leu  Ile Thr Gln 
    1490                 1495                 1500             


His Cys  Pro Ala Asp Leu Leu  Phe Gln Arg Leu Gly  Arg Leu His 
    1505                 1510                 1515             


Arg His  His Arg Lys Tyr Arg  Pro Ala Gly Phe Glu  Ile Pro Val 
    1520                 1525                 1530             


Ala Thr  Ile Leu Leu Pro Asp  Gly Glu Gly Tyr Gly  Arg His Glu 
    1535                 1540                 1545             


His Ile  Tyr Ser Asn Val Arg  Val Met Trp Arg Thr  Gln Gln His 
    1550                 1555                 1560             


Ile Glu  Glu Leu Asn Gly Ala  Ser Leu Phe Phe Pro  Asp Ala Tyr 
    1565                 1570                 1575             


Arg Gln  Trp Leu Asp Ser Ile  Tyr Asp Asp Ala Glu  Met Asp Glu 
    1580                 1585                 1590             


Pro Glu  Trp Val Gly Asn Gly  Met Asp Lys Phe Glu  Ser Ala Glu 
    1595                 1600                 1605             


Cys Glu  Lys Arg Phe Lys Ala  Arg Lys Val Leu Gln  Trp Ala Glu 
    1610                 1615                 1620             


Glu Tyr  Ser Leu Gln Asp Asn  Asp Glu Thr Ile Leu  Ala Val Thr 
    1625                 1630                 1635             


Arg Asp  Gly Glu Met Ser Leu  Pro Leu Leu Pro Tyr  Val Gln Thr 
    1640                 1645                 1650             


Ser Ser  Gly Lys Gln Leu Leu  Asp Gly Gln Val Tyr  Glu Asp Leu 
    1655                 1660                 1665             


Ser His  Glu Gln Gln Tyr Glu  Ala Leu Ala Leu Asn  Arg Val Asn 
    1670                 1675                 1680             


Val Pro  Phe Thr Trp Lys Arg  Ser Phe Ser Glu Val  Val Asp Glu 
    1685                 1690                 1695             


Asp Gly  Leu Leu Trp Leu Glu  Gly Lys Gln Asn Leu  Asp Gly Trp 
    1700                 1705                 1710             


Val Trp  Gln Gly Asn Ser Ile  Val Ile Thr Tyr Thr  Gly Asp Glu 
    1715                 1720                 1725             


Gly Met  Thr Arg Val Ile Pro  Ala Asn Pro Lys Ala  Asp Pro Thr 
    1730                 1735                 1740             


Asn Arg  Ala Lys Gly Leu Glu  Ala Val Ser Val Ala  Ser Met Tyr 
    1745                 1750                 1755             


Leu Ser  Lys Val Ile Ile Ala  Arg Ala Trp Ser Arg  Asp Leu Tyr 
    1760                 1765                 1770             


Gln Leu  His Gln Gly Leu Trp  His Leu Phe Pro Asn  Arg Pro Asp 
    1775                 1780                 1785             


Ala Ala  Arg Asp Phe Leu Phe  His Val Glu Lys Arg  Asn Thr Pro 
    1790                 1795                 1800             


Glu Gly  Cys His Val Leu Leu  Gln Ser Ala Gln Met  Pro Val Ser 
    1805                 1810                 1815             


Thr Ala  Val Ala Thr Val Ile  Lys Thr Lys Gln Val  Glu Phe Gln 
    1820                 1825                 1830             


Leu Gln  Val Gly Val Pro Leu  Tyr Phe Arg Leu Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ile Lys  Thr Ile Leu Asp Asn  Gln Lys Arg Leu Asp  Ser Lys Gly 
    1850                 1855                 1860             


Asn Ile  Lys Arg Cys Arg Val  Pro Leu Ile Lys Glu  Ala Glu Gln 
    1865                 1870                 1875             


Ile Ala  Trp Leu Gln Arg Lys  Leu Gly Asn Ala Ala  Arg Val Glu 
    1880                 1885                 1890             


Asp Val  His Pro Ile Ser Glu  Arg Pro Gln Tyr Phe  Ser Gly Asp 
    1895                 1900                 1905             


Gly Lys  Ser Gly Lys Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu 
    1910                 1915                 1920             


Thr Ile  Asn Asp Ala Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly 
    1925                 1930                 1935             


Ile Gly  Pro Ala Lys Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala 
    1940                 1945                 1950             


Pro Leu  Gly Ser Gly Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly 
    1955                 1960                 1965             


Asp Val  Glu Glu Asn Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val 
    1970                 1975                 1980             


Gly Ser  Gly Met Asn Leu Leu  Ile Asp Asn Trp Ile  Pro Val Arg 
    1985                 1990                 1995             


Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile Asn Leu  Gln Ser Leu 
    2000                 2005                 2010             


Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser Leu Pro  Arg Asp Asp 
    2015                 2020                 2025             


Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val Cys Ile  Gly Gln Ile 
    2030                 2035                 2040             


Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe Arg His  Arg Ile Met 
    2045                 2050                 2055             


Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln Leu Ile  Ala Pro Trp 
    2060                 2065                 2070             


Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu His Pro  Phe Met Gln 
    2075                 2080                 2085             


Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr Pro Met  Glu Lys Leu 
    2090                 2095                 2100             


Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys Ala Phe  Val Asn Gln 
    2105                 2110                 2115             


Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly Cys Thr  Ala Ile Ala 
    2120                 2125                 2130             


Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly Phe Gly  Gly Gly Phe 
    2135                 2140                 2145             


Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val Thr Thr  Phe Val Arg 
    2150                 2155                 2160             


Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu Asn Val  Leu Thr Leu 
    2165                 2170                 2175             


Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu Ser His  Thr Glu Asn 
    2180                 2185                 2190             


Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser Asn Glu  Ser Ile Pro 
    2195                 2200                 2205             


Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu Phe Trp  Gln Pro Ala 
    2210                 2215                 2220             


His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile Gly Lys  Cys Ser Cys 
    2225                 2230                 2235             


Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr Gly Phe  Leu Lys Glu 
    2240                 2245                 2250             


Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp Pro His  Pro His Ser 
    2255                 2260                 2265             


Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu Val Glu  Glu Lys Phe 
    2270                 2275                 2280             


Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp Thr Gln  Ile Ser Arg 
    2285                 2290                 2295             


Val Val  Val Asp Lys Ile Ile  Gln Asn Glu Asn Gly  Asn Arg Val 
    2300                 2305                 2310             


Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile Ala Pro  Gln Ser Pro 
    2315                 2320                 2325             


Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn Asn Gln  Ala Ser Ile 
    2330                 2335                 2340             


Leu Glu  Arg Arg His Asp Val  Leu Met Phe Asn Gln  Gly Trp Gln 
    2345                 2350                 2355             


Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val Thr Val  Gly Leu Gly 
    2360                 2365                 2370             


Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr Thr Phe  Ala Glu Gly 
    2375                 2380                 2385             


Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly Val Ser  Val His Glu 
    2390                 2395                 2400             


Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser Glu Leu  Leu Ile Pro 
    2405                 2410                 2415             


Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln Ala Asp  Glu Val Ile 
    2420                 2425                 2430             


Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu Cys Glu  Met Leu Phe 
    2435                 2440                 2445             


Asn Gln  Ser Val Ala Pro Tyr  Ala His His Pro Lys  Leu Ile Ser 
    2450                 2455                 2460             


Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr Lys His  Leu Arg Glu 
    2465                 2470                 2475             


Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    2480                 2485             


<210>  1886
<211>  2488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EcoCascade with Cas6-17aa-Cas3 fusion

<400>  1886

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            820                 825                 830         


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
        835                 840                 845             


Gly Ser Gly Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser 
    850                 855                 860                 


Arg Asp Leu Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn 
865                 870                 875                 880 


Arg Pro Asp Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn 
                885                 890                 895     


Thr Pro Glu Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val 
            900                 905                 910         


Ser Thr Ala Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln 
        915                 920                 925             


Leu Gln Val Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile 
    930                 935                 940                 


Lys Thr Ile Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile 
945                 950                 955                 960 


Lys Arg Cys Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp 
                965                 970                 975     


Leu Gln Arg Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro 
            980                 985                 990         


Ile Ser Glu Arg Pro Gln Tyr Phe  Ser Gly Asp Gly Lys  Ser Gly Lys 
        995                 1000                 1005             


Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu Thr Ile  Asn Asp Ala 
    1010                 1015                 1020             


Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly Ile Gly  Pro Ala Lys 
    1025                 1030                 1035             


Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala Pro Leu  Ala Asp Pro 
    1040                 1045                 1050             


Thr Asn  Arg Ala Lys Gly Leu  Glu Ala Val Ser Val  Ala Ser Met 
    1055                 1060                 1065             


Glu Pro  Phe Lys Tyr Ile Cys  His Tyr Trp Gly Lys  Ser Ser Lys 
    1070                 1075                 1080             


Ser Leu  Thr Lys Gly Asn Asp  Ile His Leu Leu Ile  Tyr His Cys 
    1085                 1090                 1095             


Leu Asp  Val Ala Ala Val Ala  Asp Cys Trp Trp Asp  Gln Ser Val 
    1100                 1105                 1110             


Val Leu  Gln Asn Thr Phe Cys  Arg Asn Glu Met Leu  Ser Lys Gln 
    1115                 1120                 1125             


Arg Val  Lys Ala Trp Leu Leu  Phe Phe Ile Ala Leu  His Asp Ile 
    1130                 1135                 1140             


Gly Lys  Phe Asp Ile Arg Phe  Gln Tyr Lys Ser Ala  Glu Ser Trp 
    1145                 1150                 1155             


Leu Lys  Leu Asn Pro Ala Thr  Pro Ser Leu Asn Gly  Pro Ser Thr 
    1160                 1165                 1170             


Gln Met  Cys Arg Lys Phe Asn  His Gly Ala Ala Gly  Leu Tyr Trp 
    1175                 1180                 1185             


Phe Asn  Gln Asp Ser Leu Ser  Glu Gln Ser Leu Gly  Asp Phe Phe 
    1190                 1195                 1200             


Ser Phe  Phe Asp Ala Ala Pro  His Pro Tyr Glu Ser  Trp Phe Pro 
    1205                 1210                 1215             


Trp Val  Glu Ala Val Thr Gly  His His Gly Phe Ile  Leu His Ser 
    1220                 1225                 1230             


Gln Asp  Gln Asp Lys Ser Arg  Trp Glu Met Pro Ala  Ser Leu Ala 
    1235                 1240                 1245             


Ser Tyr  Ala Ala Gln Asp Lys  Gln Ala Arg Glu Glu  Trp Ile Ser 
    1250                 1255                 1260             


Val Leu  Glu Ala Leu Phe Leu  Thr Pro Ala Gly Leu  Ser Ile Asn 
    1265                 1270                 1275             


Asp Ile  Pro Pro Asp Cys Ser  Ser Leu Leu Ala Gly  Phe Cys Ser 
    1280                 1285                 1290             


Leu Ala  Asp Trp Leu Gly Ser  Trp Thr Thr Thr Asn  Thr Phe Leu 
    1295                 1300                 1305             


Phe Asn  Glu Asp Ala Pro Ser  Asp Ile Asn Ala Leu  Arg Thr Tyr 
    1310                 1315                 1320             


Phe Gln  Asp Arg Gln Gln Asp  Ala Ser Arg Val Leu  Glu Leu Ser 
    1325                 1330                 1335             


Gly Leu  Val Ser Asn Lys Arg  Cys Tyr Glu Gly Val  His Ala Leu 
    1340                 1345                 1350             


Leu Asp  Asn Gly Tyr Gln Pro  Arg Gln Leu Gln Val  Leu Val Asp 
    1355                 1360                 1365             


Ala Leu  Pro Val Ala Pro Gly  Leu Thr Val Ile Glu  Ala Pro Thr 
    1370                 1375                 1380             


Gly Ser  Gly Lys Thr Glu Thr  Ala Leu Ala Tyr Ala  Trp Lys Leu 
    1385                 1390                 1395             


Ile Asp  Gln Gln Ile Ala Asp  Ser Val Ile Phe Ala  Leu Pro Thr 
    1400                 1405                 1410             


Gln Ala  Thr Ala Asn Ala Met  Leu Thr Arg Met Glu  Ala Ser Ala 
    1415                 1420                 1425             


Ser His  Leu Phe Ser Ser Pro  Asn Leu Ile Leu Ala  His Gly Asn 
    1430                 1435                 1440             


Ser Arg  Phe Asn His Leu Phe  Gln Ser Ile Lys Ser  Arg Ala Ile 
    1445                 1450                 1455             


Thr Glu  Gln Gly Gln Glu Glu  Ala Trp Val Gln Cys  Cys Gln Trp 
    1460                 1465                 1470             


Leu Ser  Gln Ser Asn Lys Lys  Val Phe Leu Gly Gln  Ile Gly Val 
    1475                 1480                 1485             


Cys Thr  Ile Asp Gln Val Leu  Ile Ser Val Leu Pro  Val Lys His 
    1490                 1495                 1500             


Arg Phe  Ile Arg Gly Leu Gly  Ile Gly Arg Ser Val  Leu Ile Val 
    1505                 1510                 1515             


Asp Glu  Val His Ala Tyr Asp  Thr Tyr Met Asn Gly  Leu Leu Glu 
    1520                 1525                 1530             


Ala Val  Leu Lys Ala Gln Ala  Asp Val Gly Gly Ser  Val Ile Leu 
    1535                 1540                 1545             


Leu Ser  Ala Thr Leu Pro Met  Lys Gln Lys Gln Lys  Leu Leu Asp 
    1550                 1555                 1560             


Thr Tyr  Gly Leu His Thr Asp  Pro Val Glu Asn Asn  Ser Ala Tyr 
    1565                 1570                 1575             


Pro Leu  Ile Asn Trp Arg Gly  Val Asn Gly Ala Gln  Arg Phe Asp 
    1580                 1585                 1590             


Leu Leu  Ala His Pro Glu Gln  Leu Pro Pro Arg Phe  Ser Ile Gln 
    1595                 1600                 1605             


Pro Glu  Pro Ile Cys Leu Ala  Asp Met Leu Pro Asp  Leu Thr Met 
    1610                 1615                 1620             


Leu Glu  Arg Met Ile Ala Ala  Ala Asn Ala Gly Ala  Gln Val Cys 
    1625                 1630                 1635             


Leu Ile  Cys Asn Leu Val Asp  Val Ala Gln Val Cys  Tyr Gln Arg 
    1640                 1645                 1650             


Leu Lys  Glu Leu Asn Asn Thr  Gln Val Asp Ile Asp  Leu Phe His 
    1655                 1660                 1665             


Ala Arg  Phe Thr Leu Asn Asp  Arg Arg Glu Lys Glu  Asn Arg Val 
    1670                 1675                 1680             


Ile Ser  Asn Phe Gly Lys Asn  Gly Lys Arg Asn Val  Gly Arg Ile 
    1685                 1690                 1695             


Leu Val  Ala Thr Gln Val Val  Glu Gln Ser Leu Asp  Val Asp Phe 
    1700                 1705                 1710             


Asp Trp  Leu Ile Thr Gln His  Cys Pro Ala Asp Leu  Leu Phe Gln 
    1715                 1720                 1725             


Arg Leu  Gly Arg Leu His Arg  His His Arg Lys Tyr  Arg Pro Ala 
    1730                 1735                 1740             


Gly Phe  Glu Ile Pro Val Ala  Thr Ile Leu Leu Pro  Asp Gly Glu 
    1745                 1750                 1755             


Gly Tyr  Gly Arg His Glu His  Ile Tyr Ser Asn Val  Arg Val Met 
    1760                 1765                 1770             


Trp Arg  Thr Gln Gln His Ile  Glu Glu Leu Asn Gly  Ala Ser Leu 
    1775                 1780                 1785             


Phe Phe  Pro Asp Ala Tyr Arg  Gln Trp Leu Asp Ser  Ile Tyr Asp 
    1790                 1795                 1800             


Asp Ala  Glu Met Asp Glu Pro  Glu Trp Val Gly Asn  Gly Met Asp 
    1805                 1810                 1815             


Lys Phe  Glu Ser Ala Glu Cys  Glu Lys Arg Phe Lys  Ala Arg Lys 
    1820                 1825                 1830             


Val Leu  Gln Trp Ala Glu Glu  Tyr Ser Leu Gln Asp  Asn Asp Glu 
    1835                 1840                 1845             


Thr Ile  Leu Ala Val Thr Arg  Asp Gly Glu Met Ser  Leu Pro Leu 
    1850                 1855                 1860             


Leu Pro  Tyr Val Gln Thr Ser  Ser Gly Lys Gln Leu  Leu Asp Gly 
    1865                 1870                 1875             


Gln Val  Tyr Glu Asp Leu Ser  His Glu Gln Gln Tyr  Glu Ala Leu 
    1880                 1885                 1890             


Ala Leu  Asn Arg Val Asn Val  Pro Phe Thr Trp Lys  Arg Ser Phe 
    1895                 1900                 1905             


Ser Glu  Val Val Asp Glu Asp  Gly Leu Leu Trp Leu  Glu Gly Lys 
    1910                 1915                 1920             


Gln Asn  Leu Asp Gly Trp Val  Trp Gln Gly Asn Ser  Ile Val Ile 
    1925                 1930                 1935             


Thr Tyr  Thr Gly Asp Glu Gly  Met Thr Arg Val Ile  Pro Ala Asn 
    1940                 1945                 1950             


Pro Lys  Gly Ser Gly Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly 
    1955                 1960                 1965             


Asp Val  Glu Glu Asn Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val 
    1970                 1975                 1980             


Gly Ser  Gly Met Asn Leu Leu  Ile Asp Asn Trp Ile  Pro Val Arg 
    1985                 1990                 1995             


Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile Asn Leu  Gln Ser Leu 
    2000                 2005                 2010             


Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser Leu Pro  Arg Asp Asp 
    2015                 2020                 2025             


Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val Cys Ile  Gly Gln Ile 
    2030                 2035                 2040             


Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe Arg His  Arg Ile Met 
    2045                 2050                 2055             


Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln Leu Ile  Ala Pro Trp 
    2060                 2065                 2070             


Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu His Pro  Phe Met Gln 
    2075                 2080                 2085             


Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr Pro Met  Glu Lys Leu 
    2090                 2095                 2100             


Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys Ala Phe  Val Asn Gln 
    2105                 2110                 2115             


Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly Cys Thr  Ala Ile Ala 
    2120                 2125                 2130             


Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly Phe Gly  Gly Gly Phe 
    2135                 2140                 2145             


Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val Thr Thr  Phe Val Arg 
    2150                 2155                 2160             


Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu Asn Val  Leu Thr Leu 
    2165                 2170                 2175             


Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu Ser His  Thr Glu Asn 
    2180                 2185                 2190             


Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser Asn Glu  Ser Ile Pro 
    2195                 2200                 2205             


Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu Phe Trp  Gln Pro Ala 
    2210                 2215                 2220             


His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile Gly Lys  Cys Ser Cys 
    2225                 2230                 2235             


Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr Gly Phe  Leu Lys Glu 
    2240                 2245                 2250             


Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp Pro His  Pro His Ser 
    2255                 2260                 2265             


Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu Val Glu  Glu Lys Phe 
    2270                 2275                 2280             


Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp Thr Gln  Ile Ser Arg 
    2285                 2290                 2295             


Val Val  Val Asp Lys Ile Ile  Gln Asn Glu Asn Gly  Asn Arg Val 
    2300                 2305                 2310             


Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile Ala Pro  Gln Ser Pro 
    2315                 2320                 2325             


Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn Asn Gln  Ala Ser Ile 
    2330                 2335                 2340             


Leu Glu  Arg Arg His Asp Val  Leu Met Phe Asn Gln  Gly Trp Gln 
    2345                 2350                 2355             


Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val Thr Val  Gly Leu Gly 
    2360                 2365                 2370             


Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr Thr Phe  Ala Glu Gly 
    2375                 2380                 2385             


Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly Val Ser  Val His Glu 
    2390                 2395                 2400             


Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser Glu Leu  Leu Ile Pro 
    2405                 2410                 2415             


Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln Ala Asp  Glu Val Ile 
    2420                 2425                 2430             


Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu Cys Glu  Met Leu Phe 
    2435                 2440                 2445             


Asn Gln  Ser Val Ala Pro Tyr  Ala His His Pro Lys  Leu Ile Ser 
    2450                 2455                 2460             


Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr Lys His  Leu Arg Glu 
    2465                 2470                 2475             


Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    2480                 2485             


<210>  1887
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: sgRNA templating forward

<400>  1887
agtaataata cgactcacta tag                                               23


<210>  1888
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: sgRNA templating oligo reverse

<400>  1888
aaaaaagcac cgactcggtg ccactttttc aagttgataa cggactagcc ttattttaac       60

ttgctatttc tagctctaaa ac                                                82


<210>  1889
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock F1

<400>  1889
taatacgact cactatagtg gatatgggcg atgatctggt tttagagcta gaaatagc         58


<210>  1890
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock F2

<400>  1890
taatacgact cactataggt tgaagccctt ctggatatgt tttagagcta gaaatagc         58


<210>  1891
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock F3

<400>  1891
taatacgact cactatagag ttgaagccct tctggatagt tttagagcta gaaatagc         58


<210>  1892
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock F4

<400>  1892
taatacgact cactatagcc gtgtagttga agcccttcgt tttagagcta gaaatagc         58


<210>  1893
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock F5

<400>  1893
taatacgact cactataggt cacaaatttg gcgctgcagt tttagagcta gaaatagc         58


<210>  1894
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock F6

<400>  1894
taatacgact cactataggt cacaaatttg gcgctgcagt tttagagcta gaaatagc         58


<210>  1895
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock R1

<400>  1895
taatacgact cactatagga tcatcgccca tatccagagt tttagagcta gaaatagc         58


<210>  1896
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock R2

<400>  1896
taatacgact cactatagat catcgcccat atccagaagt tttagagcta gaaatagc         58


<210>  1897
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock R3

<400>  1897
taatacgact cactatagcc agaagggctt caactacagt tttagagcta gaaatagc         58


<210>  1898
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock R4

<400>  1898
taatacgact cactatagac acggtgtttg actgtaaggt tttagagcta gaaatagc         58


<210>  1899
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Roadblock R5

<400>  1899
taatacgact cactatagca gcgccaaatt tgtgaccagt tttagagcta gaaatagc         58


<210>  1900
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Eco-mCas3 (D452A)

<400>  1900

Met Glu Pro Phe Lys Tyr Ile Cys His Tyr Trp Gly Lys Ser Ser Lys 
1               5                   10                  15      


Ser Leu Thr Lys Gly Asn Asp Ile His Leu Leu Ile Tyr His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Val Ala Asp Cys Trp Trp Asp Gln Ser Val Val Leu 
        35                  40                  45              


Gln Asn Thr Phe Cys Arg Asn Glu Met Leu Ser Lys Gln Arg Val Lys 
    50                  55                  60                  


Ala Trp Leu Leu Phe Phe Ile Ala Leu His Asp Ile Gly Lys Phe Asp 
65                  70                  75                  80  


Ile Arg Phe Gln Tyr Lys Ser Ala Glu Ser Trp Leu Lys Leu Asn Pro 
                85                  90                  95      


Ala Thr Pro Ser Leu Asn Gly Pro Ser Thr Gln Met Cys Arg Lys Phe 
            100                 105                 110         


Asn His Gly Ala Ala Gly Leu Tyr Trp Phe Asn Gln Asp Ser Leu Ser 
        115                 120                 125             


Glu Gln Ser Leu Gly Asp Phe Phe Ser Phe Phe Asp Ala Ala Pro His 
    130                 135                 140                 


Pro Tyr Glu Ser Trp Phe Pro Trp Val Glu Ala Val Thr Gly His His 
145                 150                 155                 160 


Gly Phe Ile Leu His Ser Gln Asp Gln Asp Lys Ser Arg Trp Glu Met 
                165                 170                 175     


Pro Ala Ser Leu Ala Ser Tyr Ala Ala Gln Asp Lys Gln Ala Arg Glu 
            180                 185                 190         


Glu Trp Ile Ser Val Leu Glu Ala Leu Phe Leu Thr Pro Ala Gly Leu 
        195                 200                 205             


Ser Ile Asn Asp Ile Pro Pro Asp Cys Ser Ser Leu Leu Ala Gly Phe 
    210                 215                 220                 


Cys Ser Leu Ala Asp Trp Leu Gly Ser Trp Thr Thr Thr Asn Thr Phe 
225                 230                 235                 240 


Leu Phe Asn Glu Asp Ala Pro Ser Asp Ile Asn Ala Leu Arg Thr Tyr 
                245                 250                 255     


Phe Gln Asp Arg Gln Gln Asp Ala Ser Arg Val Leu Glu Leu Ser Gly 
            260                 265                 270         


Leu Val Ser Asn Lys Arg Cys Tyr Glu Gly Val His Ala Leu Leu Asp 
        275                 280                 285             


Asn Gly Tyr Gln Pro Arg Gln Leu Gln Val Leu Val Asp Ala Leu Pro 
    290                 295                 300                 


Val Ala Pro Gly Leu Thr Val Ile Glu Ala Pro Thr Gly Ser Gly Lys 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Ala Tyr Ala Trp Lys Leu Ile Asp Gln Gln Ile 
                325                 330                 335     


Ala Asp Ser Val Ile Phe Ala Leu Pro Thr Gln Ala Thr Ala Asn Ala 
            340                 345                 350         


Met Leu Thr Arg Met Glu Ala Ser Ala Ser His Leu Phe Ser Ser Pro 
        355                 360                 365             


Asn Leu Ile Leu Ala His Gly Asn Ser Arg Phe Asn His Leu Phe Gln 
    370                 375                 380                 


Ser Ile Lys Ser Arg Ala Ile Thr Glu Gln Gly Gln Glu Glu Ala Trp 
385                 390                 395                 400 


Val Gln Cys Cys Gln Trp Leu Ser Gln Ser Asn Lys Lys Val Phe Leu 
                405                 410                 415     


Gly Gln Ile Gly Val Cys Thr Ile Asp Gln Val Leu Ile Ser Val Leu 
            420                 425                 430         


Pro Val Lys His Arg Phe Ile Arg Gly Leu Gly Ile Gly Arg Ser Val 
        435                 440                 445             


Leu Ile Val Ala Glu Val His Ala Tyr Asp Thr Tyr Met Asn Gly Leu 
    450                 455                 460                 


Leu Glu Ala Val Leu Lys Ala Gln Ala Asp Val Gly Gly Ser Val Ile 
465                 470                 475                 480 


Leu Leu Ser Ala Thr Leu Pro Met Lys Gln Lys Gln Lys Leu Leu Asp 
                485                 490                 495     


Thr Tyr Gly Leu His Thr Asp Pro Val Glu Asn Asn Ser Ala Tyr Pro 
            500                 505                 510         


Leu Ile Asn Trp Arg Gly Val Asn Gly Ala Gln Arg Phe Asp Leu Leu 
        515                 520                 525             


Ala His Pro Glu Gln Leu Pro Pro Arg Phe Ser Ile Gln Pro Glu Pro 
    530                 535                 540                 


Ile Cys Leu Ala Asp Met Leu Pro Asp Leu Thr Met Leu Glu Arg Met 
545                 550                 555                 560 


Ile Ala Ala Ala Asn Ala Gly Ala Gln Val Cys Leu Ile Cys Asn Leu 
                565                 570                 575     


Val Asp Val Ala Gln Val Cys Tyr Gln Arg Leu Lys Glu Leu Asn Asn 
            580                 585                 590         


Thr Gln Val Asp Ile Asp Leu Phe His Ala Arg Phe Thr Leu Asn Asp 
        595                 600                 605             


Arg Arg Glu Lys Glu Asn Arg Val Ile Ser Asn Phe Gly Lys Asn Gly 
    610                 615                 620                 


Lys Arg Asn Val Gly Arg Ile Leu Val Ala Thr Gln Val Val Glu Gln 
625                 630                 635                 640 


Ser Leu Asp Val Asp Phe Asp Trp Leu Ile Thr Gln His Cys Pro Ala 
                645                 650                 655     


Asp Leu Leu Phe Gln Arg Leu Gly Arg Leu His Arg His His Arg Lys 
            660                 665                 670         


Tyr Arg Pro Ala Gly Phe Glu Ile Pro Val Ala Thr Ile Leu Leu Pro 
        675                 680                 685             


Asp Gly Glu Gly Tyr Gly Arg His Glu His Ile Tyr Ser Asn Val Arg 
    690                 695                 700                 


Val Met Trp Arg Thr Gln Gln His Ile Glu Glu Leu Asn Gly Ala Ser 
705                 710                 715                 720 


Leu Phe Phe Pro Asp Ala Tyr Arg Gln Trp Leu Asp Ser Ile Tyr Asp 
                725                 730                 735     


Asp Ala Glu Met Asp Glu Pro Glu Trp Val Gly Asn Gly Met Asp Lys 
            740                 745                 750         


Phe Glu Ser Ala Glu Cys Glu Lys Arg Phe Lys Ala Arg Lys Val Leu 
        755                 760                 765             


Gln Trp Ala Glu Glu Tyr Ser Leu Gln Asp Asn Asp Glu Thr Ile Leu 
    770                 775                 780                 


Ala Val Thr Arg Asp Gly Glu Met Ser Leu Pro Leu Leu Pro Tyr Val 
785                 790                 795                 800 


Gln Thr Ser Ser Gly Lys Gln Leu Leu Asp Gly Gln Val Tyr Glu Asp 
                805                 810                 815     


Leu Ser His Glu Gln Gln Tyr Glu Ala Leu Ala Leu Asn Arg Val Asn 
            820                 825                 830         


Val Pro Phe Thr Trp Lys Arg Ser Phe Ser Glu Val Val Asp Glu Asp 
        835                 840                 845             


Gly Leu Leu Trp Leu Glu Gly Lys Gln Asn Leu Asp Gly Trp Val Trp 
    850                 855                 860                 


Gln Gly Asn Ser Ile Val Ile Thr Tyr Thr Gly Asp Glu Gly Met Thr 
865                 870                 875                 880 


Arg Val Ile Pro Ala Asn Pro Lys 
                885             


<210>  1901
<211>  2488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: nCas3-17aa-EcoCascade

<400>  1901

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            820                 825                 830         


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
        835                 840                 845             


Gly Ser Gly Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser 
    850                 855                 860                 


Arg Asp Leu Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn 
865                 870                 875                 880 


Arg Pro Asp Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn 
                885                 890                 895     


Thr Pro Glu Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val 
            900                 905                 910         


Ser Thr Ala Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln 
        915                 920                 925             


Leu Gln Val Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile 
    930                 935                 940                 


Lys Thr Ile Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile 
945                 950                 955                 960 


Lys Arg Cys Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp 
                965                 970                 975     


Leu Gln Arg Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro 
            980                 985                 990         


Ile Ser Glu Arg Pro Gln Tyr Phe  Ser Gly Asp Gly Lys  Ser Gly Lys 
        995                 1000                 1005             


Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu Thr Ile  Asn Asp Ala 
    1010                 1015                 1020             


Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly Ile Gly  Pro Ala Lys 
    1025                 1030                 1035             


Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala Pro Leu  Gly Ser Gly 
    1040                 1045                 1050             


Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn 
    1055                 1060                 1065             


Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val Gly Ser  Gly Met Glu 
    1070                 1075                 1080             


Pro Phe  Lys Tyr Ile Cys His  Tyr Trp Gly Lys Ser  Ser Lys Ser 
    1085                 1090                 1095             


Leu Thr  Lys Gly Asn Asp Ile  His Leu Leu Ile Tyr  His Cys Leu 
    1100                 1105                 1110             


Asp Val  Ala Ala Val Ala Asp  Cys Trp Trp Asp Gln  Ser Val Val 
    1115                 1120                 1125             


Leu Gln  Asn Thr Phe Cys Arg  Asn Glu Met Leu Ser  Lys Gln Arg 
    1130                 1135                 1140             


Val Lys  Ala Trp Leu Leu Phe  Phe Ile Ala Leu His  Asp Ile Gly 
    1145                 1150                 1155             


Lys Phe  Asp Ile Arg Phe Gln  Tyr Lys Ser Ala Glu  Ser Trp Leu 
    1160                 1165                 1170             


Lys Leu  Asn Pro Ala Thr Pro  Ser Leu Asn Gly Pro  Ser Thr Gln 
    1175                 1180                 1185             


Met Cys  Arg Lys Phe Asn His  Gly Ala Ala Gly Leu  Tyr Trp Phe 
    1190                 1195                 1200             


Asn Gln  Asp Ser Leu Ser Glu  Gln Ser Leu Gly Asp  Phe Phe Ser 
    1205                 1210                 1215             


Phe Phe  Asp Ala Ala Pro His  Pro Tyr Glu Ser Trp  Phe Pro Trp 
    1220                 1225                 1230             


Val Glu  Ala Val Thr Gly His  His Gly Phe Ile Leu  His Ser Gln 
    1235                 1240                 1245             


Asp Gln  Asp Lys Ser Arg Trp  Glu Met Pro Ala Ser  Leu Ala Ser 
    1250                 1255                 1260             


Tyr Ala  Ala Gln Asp Lys Gln  Ala Arg Glu Glu Trp  Ile Ser Val 
    1265                 1270                 1275             


Leu Glu  Ala Leu Phe Leu Thr  Pro Ala Gly Leu Ser  Ile Asn Asp 
    1280                 1285                 1290             


Ile Pro  Pro Asp Cys Ser Ser  Leu Leu Ala Gly Phe  Cys Ser Leu 
    1295                 1300                 1305             


Ala Asp  Trp Leu Gly Ser Trp  Thr Thr Thr Asn Thr  Phe Leu Phe 
    1310                 1315                 1320             


Asn Glu  Asp Ala Pro Ser Asp  Ile Asn Ala Leu Arg  Thr Tyr Phe 
    1325                 1330                 1335             


Gln Asp  Arg Gln Gln Asp Ala  Ser Arg Val Leu Glu  Leu Ser Gly 
    1340                 1345                 1350             


Leu Val  Ser Asn Lys Arg Cys  Tyr Glu Gly Val His  Ala Leu Leu 
    1355                 1360                 1365             


Asp Asn  Gly Tyr Gln Pro Arg  Gln Leu Gln Val Leu  Val Asp Ala 
    1370                 1375                 1380             


Leu Pro  Val Ala Pro Gly Leu  Thr Val Ile Glu Ala  Pro Thr Gly 
    1385                 1390                 1395             


Ser Gly  Lys Thr Glu Thr Ala  Leu Ala Tyr Ala Trp  Lys Leu Ile 
    1400                 1405                 1410             


Asp Gln  Gln Ile Ala Asp Ser  Val Ile Phe Ala Leu  Pro Thr Gln 
    1415                 1420                 1425             


Ala Thr  Ala Asn Ala Met Leu  Thr Arg Met Glu Ala  Ser Ala Ser 
    1430                 1435                 1440             


His Leu  Phe Ser Ser Pro Asn  Leu Ile Leu Ala His  Gly Asn Ser 
    1445                 1450                 1455             


Arg Phe  Asn His Leu Phe Gln  Ser Ile Lys Ser Arg  Ala Ile Thr 
    1460                 1465                 1470             


Glu Gln  Gly Gln Glu Glu Ala  Trp Val Gln Cys Cys  Gln Trp Leu 
    1475                 1480                 1485             


Ser Gln  Ser Asn Lys Lys Val  Phe Leu Gly Gln Ile  Gly Val Cys 
    1490                 1495                 1500             


Thr Ile  Asp Gln Val Leu Ile  Ser Val Leu Pro Val  Lys His Arg 
    1505                 1510                 1515             


Phe Ile  Arg Gly Leu Gly Ile  Gly Arg Ser Val Leu  Ile Val Ala 
    1520                 1525                 1530             


Glu Val  His Ala Tyr Asp Thr  Tyr Met Asn Gly Leu  Leu Glu Ala 
    1535                 1540                 1545             


Val Leu  Lys Ala Gln Ala Asp  Val Gly Gly Ser Val  Ile Leu Leu 
    1550                 1555                 1560             


Ser Ala  Thr Leu Pro Met Lys  Gln Lys Gln Lys Leu  Leu Asp Thr 
    1565                 1570                 1575             


Tyr Gly  Leu His Thr Asp Pro  Val Glu Asn Asn Ser  Ala Tyr Pro 
    1580                 1585                 1590             


Leu Ile  Asn Trp Arg Gly Val  Asn Gly Ala Gln Arg  Phe Asp Leu 
    1595                 1600                 1605             


Leu Ala  His Pro Glu Gln Leu  Pro Pro Arg Phe Ser  Ile Gln Pro 
    1610                 1615                 1620             


Glu Pro  Ile Cys Leu Ala Asp  Met Leu Pro Asp Leu  Thr Met Leu 
    1625                 1630                 1635             


Glu Arg  Met Ile Ala Ala Ala  Asn Ala Gly Ala Gln  Val Cys Leu 
    1640                 1645                 1650             


Ile Cys  Asn Leu Val Asp Val  Ala Gln Val Cys Tyr  Gln Arg Leu 
    1655                 1660                 1665             


Lys Glu  Leu Asn Asn Thr Gln  Val Asp Ile Asp Leu  Phe His Ala 
    1670                 1675                 1680             


Arg Phe  Thr Leu Asn Asp Arg  Arg Glu Lys Glu Asn  Arg Val Ile 
    1685                 1690                 1695             


Ser Asn  Phe Gly Lys Asn Gly  Lys Arg Asn Val Gly  Arg Ile Leu 
    1700                 1705                 1710             


Val Ala  Thr Gln Val Val Glu  Gln Ser Leu Asp Val  Asp Phe Asp 
    1715                 1720                 1725             


Trp Leu  Ile Thr Gln His Cys  Pro Ala Asp Leu Leu  Phe Gln Arg 
    1730                 1735                 1740             


Leu Gly  Arg Leu His Arg His  His Arg Lys Tyr Arg  Pro Ala Gly 
    1745                 1750                 1755             


Phe Glu  Ile Pro Val Ala Thr  Ile Leu Leu Pro Asp  Gly Glu Gly 
    1760                 1765                 1770             


Tyr Gly  Arg His Glu His Ile  Tyr Ser Asn Val Arg  Val Met Trp 
    1775                 1780                 1785             


Arg Thr  Gln Gln His Ile Glu  Glu Leu Asn Gly Ala  Ser Leu Phe 
    1790                 1795                 1800             


Phe Pro  Asp Ala Tyr Arg Gln  Trp Leu Asp Ser Ile  Tyr Asp Asp 
    1805                 1810                 1815             


Ala Glu  Met Asp Glu Pro Glu  Trp Val Gly Asn Gly  Met Asp Lys 
    1820                 1825                 1830             


Phe Glu  Ser Ala Glu Cys Glu  Lys Arg Phe Lys Ala  Arg Lys Val 
    1835                 1840                 1845             


Leu Gln  Trp Ala Glu Glu Tyr  Ser Leu Gln Asp Asn  Asp Glu Thr 
    1850                 1855                 1860             


Ile Leu  Ala Val Thr Arg Asp  Gly Glu Met Ser Leu  Pro Leu Leu 
    1865                 1870                 1875             


Pro Tyr  Val Gln Thr Ser Ser  Gly Lys Gln Leu Leu  Asp Gly Gln 
    1880                 1885                 1890             


Val Tyr  Glu Asp Leu Ser His  Glu Gln Gln Tyr Glu  Ala Leu Ala 
    1895                 1900                 1905             


Leu Asn  Arg Val Asn Val Pro  Phe Thr Trp Lys Arg  Ser Phe Ser 
    1910                 1915                 1920             


Glu Val  Val Asp Glu Asp Gly  Leu Leu Trp Leu Glu  Gly Lys Gln 
    1925                 1930                 1935             


Asn Leu  Asp Gly Trp Val Trp  Gln Gly Asn Ser Ile  Val Ile Thr 
    1940                 1945                 1950             


Tyr Thr  Gly Asp Glu Gly Met  Thr Arg Val Ile Pro  Ala Asn Pro 
    1955                 1960                 1965             


Lys Ala  Asp Pro Thr Asn Arg  Ala Lys Gly Leu Glu  Ala Val Ser 
    1970                 1975                 1980             


Val Ala  Ser Met Asn Leu Leu  Ile Asp Asn Trp Ile  Pro Val Arg 
    1985                 1990                 1995             


Pro Arg  Asn Gly Gly Lys Val  Gln Ile Ile Asn Leu  Gln Ser Leu 
    2000                 2005                 2010             


Tyr Cys  Ser Arg Asp Gln Trp  Arg Leu Ser Leu Pro  Arg Asp Asp 
    2015                 2020                 2025             


Met Glu  Leu Ala Ala Leu Ala  Leu Leu Val Cys Ile  Gly Gln Ile 
    2030                 2035                 2040             


Ile Ala  Pro Ala Lys Asp Asp  Val Glu Phe Arg His  Arg Ile Met 
    2045                 2050                 2055             


Asn Pro  Leu Thr Glu Asp Glu  Phe Gln Gln Leu Ile  Ala Pro Trp 
    2060                 2065                 2070             


Ile Asp  Met Phe Tyr Leu Asn  His Ala Glu His Pro  Phe Met Gln 
    2075                 2080                 2085             


Thr Lys  Gly Val Lys Ala Asn  Asp Val Thr Pro Met  Glu Lys Leu 
    2090                 2095                 2100             


Leu Ala  Gly Val Ser Gly Ala  Thr Asn Cys Ala Phe  Val Asn Gln 
    2105                 2110                 2115             


Pro Gly  Gln Gly Glu Ala Leu  Cys Gly Gly Cys Thr  Ala Ile Ala 
    2120                 2125                 2130             


Leu Phe  Asn Gln Ala Asn Gln  Ala Pro Gly Phe Gly  Gly Gly Phe 
    2135                 2140                 2145             


Lys Ser  Gly Leu Arg Gly Gly  Thr Pro Val Thr Thr  Phe Val Arg 
    2150                 2155                 2160             


Gly Ile  Asp Leu Arg Ser Thr  Val Leu Leu Asn Val  Leu Thr Leu 
    2165                 2170                 2175             


Pro Arg  Leu Gln Lys Gln Phe  Pro Asn Glu Ser His  Thr Glu Asn 
    2180                 2185                 2190             


Gln Pro  Thr Trp Ile Lys Pro  Ile Lys Ser Asn Glu  Ser Ile Pro 
    2195                 2200                 2205             


Ala Ser  Ser Ile Gly Phe Val  Arg Gly Leu Phe Trp  Gln Pro Ala 
    2210                 2215                 2220             


His Ile  Glu Leu Cys Asp Pro  Ile Gly Ile Gly Lys  Cys Ser Cys 
    2225                 2230                 2235             


Cys Gly  Gln Glu Ser Asn Leu  Arg Tyr Thr Gly Phe  Leu Lys Glu 
    2240                 2245                 2250             


Lys Phe  Thr Phe Thr Val Asn  Gly Leu Trp Pro His  Pro His Ser 
    2255                 2260                 2265             


Pro Cys  Leu Val Thr Val Lys  Lys Gly Glu Val Glu  Glu Lys Phe 
    2270                 2275                 2280             


Leu Ala  Phe Thr Thr Ser Ala  Pro Ser Trp Thr Gln  Ile Ser Arg 
    2285                 2290                 2295             


Val Val  Val Asp Lys Ile Ile  Gln Asn Glu Asn Gly  Asn Arg Val 
    2300                 2305                 2310             


Ala Ala  Val Val Asn Gln Phe  Arg Asn Ile Ala Pro  Gln Ser Pro 
    2315                 2320                 2325             


Leu Glu  Leu Ile Met Gly Gly  Tyr Arg Asn Asn Gln  Ala Ser Ile 
    2330                 2335                 2340             


Leu Glu  Arg Arg His Asp Val  Leu Met Phe Asn Gln  Gly Trp Gln 
    2345                 2350                 2355             


Gln Tyr  Gly Asn Val Ile Asn  Glu Ile Val Thr Val  Gly Leu Gly 
    2360                 2365                 2370             


Tyr Lys  Thr Ala Leu Arg Lys  Ala Leu Tyr Thr Phe  Ala Glu Gly 
    2375                 2380                 2385             


Phe Lys  Asn Lys Asp Phe Lys  Gly Ala Gly Val Ser  Val His Glu 
    2390                 2395                 2400             


Thr Ala  Glu Arg His Phe Tyr  Arg Gln Ser Glu Leu  Leu Ile Pro 
    2405                 2410                 2415             


Asp Val  Leu Ala Asn Val Asn  Phe Ser Gln Ala Asp  Glu Val Ile 
    2420                 2425                 2430             


Ala Asp  Leu Arg Asp Lys Leu  His Gln Leu Cys Glu  Met Leu Phe 
    2435                 2440                 2445             


Asn Gln  Ser Val Ala Pro Tyr  Ala His His Pro Lys  Leu Ile Ser 
    2450                 2455                 2460             


Thr Leu  Ala Leu Ala Arg Ala  Thr Leu Tyr Lys His  Leu Arg Glu 
    2465                 2470                 2475             


Leu Lys  Pro Gln Gly Gly Pro  Ser Asn Gly 
    2480                 2485             


<210>  1902
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 1 spacer

<400>  1902
tctgtctgcc tattcaccga ttttgattct ca                                     32


<210>  1903
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 2 spacer

<400>  1903
taaggattct gatgtgtata tcacagacaa aa                                     32


<210>  1904
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 3 spacer

<400>  1904
gattctgatg tgtatatcac agacaaaact gt                                     32


<210>  1905
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 4 spacer

<400>  1905
tccatagacc tcatgtctag cacagttttg tc                                     32


<210>  1906
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 5 spacer

<400>  1906
agcaacagtg ctgtggcctg gagcaacaaa tc                                     32


<210>  1907
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 6 spacer

<400>  1907
tcagatttgt tgctccaggc cacagcactg tt                                     32


<210>  1908
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 7 spacer

<400>  1908
gcgtttgcac atgcaaagtc agatttgttg ct                                     32


<210>  1909
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 8 spacer

<400>  1909
gtgtcttctg gaataatgct gttgttgaag gc                                     32


<210>  1910
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 1 primer

<400>  1910
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acactgagaa       60

tcaaaatcgg tgaataggca gacagacggt tcatccccgc aggtgcgggg aacactgaga      120

atcaaaatcg gtgaataggc agacagacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1911
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 2 primer

<400>  1911
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacttttgt       60

ctgtgatata cacatcagaa tccttacggt tcatccccgc aggtgcgggg aacacttttg      120

tctgtgatat acacatcaga atccttacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1912
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 3 primer

<400>  1912
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacacagtt       60

ttgtctgtga tatacacatc agaatccggt tcatccccgc aggtgcgggg aacacacagt      120

tttgtctgtg atatacacat cagaatccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1913
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 4 primer

<400>  1913
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgacaaa       60

actgtgctag acatgaggtc tatggacggt tcatccccgc aggtgcgggg aacacgacaa      120

aactgtgcta gacatgaggt ctatggacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1914
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 5 primer

<400>  1914
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgatttg       60

ttgctccagg ccacagcact gttgctcggt tcatccccgc aggtgcgggg aacacgattt      120

gttgctccag gccacagcac tgttgctcgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1915
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 6 primer

<400>  1915
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacaacagt       60

gctgtggcct ggagcaacaa atctgacggt tcatccccgc aggtgcgggg aacacaacag      120

tgctgtggcc tggagcaaca aatctgacgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1916
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 7 primer

<400>  1916
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacagcaac       60

aaatctgact ttgcatgtgc aaacgccggt tcatccccgc aggtgcgggg aacacagcaa      120

caaatctgac tttgcatgtg caaacgccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1917
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRAC 8 primer

<400>  1917
cccagctggt tctttccgaa aaaaacggtt catccccgca ggtgcgggga acacgccttc       60

aacaacagca ttattccaga agacaccggt tcatccccgc aggtgcgggg aacacgcctt      120

caacaacagc attattccag aagacaccgg ttcatccccg caggtgcggg gaacacggtg      180

tttcgtcctt tccacaagat                                                  200


<210>  1918
<211>  1685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PseCascade polycistronic plasmid

<400>  1918

Met Gly Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Thr Arg Phe 
1               5                   10                  15      


Val Gln Leu His Leu Leu Thr Ser Tyr Pro Pro Ala Asn Leu Asn Arg 
            20                  25                  30          


Asp Asp Leu Gly Asn Pro Lys Thr Ala Arg Leu Gly Gly Val Glu Arg 
        35                  40                  45              


Leu Arg Val Ser Ser Gln Ser Leu Lys Arg Ala Trp Arg Thr Ser Glu 
    50                  55                  60                  


Leu Phe Gln Gln Gln Leu Ala Gly Thr Ile Gly Thr Arg Thr Lys Arg 
65                  70                  75                  80  


Leu Gly Ile Glu Val Phe Glu Ala Leu Leu Gly Ala Gly Val Thr Glu 
                85                  90                  95      


Lys Gln Ala Arg Glu Trp Ala Gly Gln Ile Ala Lys Val Tyr Gly Ala 
            100                 105                 110         


Ala Lys Lys Asp Asn Pro Leu Glu Ile Glu Gln Leu Val His Ile Ala 
        115                 120                 125             


Pro Glu Glu Arg Ala Ser Leu Asp Gln Leu Val Ala Thr Leu Ala Ala 
    130                 135                 140                 


Glu Lys Arg Gly Pro Thr Asp Glu Glu Leu Asp Ala Leu Leu His His 
145                 150                 155                 160 


Gln Thr Ala Val Asp Ile Ala Met Phe Gly Arg Met Leu Ala Ser Lys 
                165                 170                 175     


Thr Gln Phe Asn Gly Glu Ala Ala Val Gln Val Ala His Ala Ile Gly 
            180                 185                 190         


Val His Ala Ser Ala Ile Glu Asp Asp Tyr Phe Thr Ala Val Asp Asp 
        195                 200                 205             


Leu Asn Arg Asn Asp Pro Gly Ala Ala His Ile Gly Glu Ser Gly Phe 
    210                 215                 220                 


Ala Ala Ala Val Phe Tyr Gln Tyr Ile Cys Ile Asp Arg Asp Leu Leu 
225                 230                 235                 240 


Lys Arg Asn Leu Gly Gly Asp Glu Val Leu Thr Gln Lys Ala Leu Arg 
                245                 250                 255     


Ala Leu Thr Glu Ala Ala Leu Lys Val Gly Pro Ser Gly Lys Gln Asn 
            260                 265                 270         


Ser Phe Ala Ser Arg Ala Phe Ala His Phe Ala Leu Ala Glu Lys Gly 
        275                 280                 285             


Thr Asp Gln Pro Arg Ser Leu Ser Leu Ala Phe Val Lys Pro Val Ala 
    290                 295                 300                 


Gly Thr Asp Tyr Ala Gly Asp Ala Val Ala Ala Leu Gln Gln Val Arg 
305                 310                 315                 320 


Asp Asn Met Asp Lys Val Tyr Gly Val Cys Ala Glu Ser Arg Cys Gln 
                325                 330                 335     


Phe Asn Val Leu Thr Gly Glu Gly Ser Val Ala Asp Leu Leu Asp Phe 
            340                 345                 350         


Val Ala Ala Glu Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
        355                 360                 365             


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
    370                 375                 380                 


Gly Ser Gly Met Lys Pro Arg Lys Pro Arg Leu Asn Glu Ala Gln Gln 
385                 390                 395                 400 


Arg Trp Val Arg Asp Trp Trp Arg Ala Leu Gln Pro Arg Ala Glu Gly 
                405                 410                 415     


Asp Glu Pro Ile Pro Gly Glu Leu Ser Val Met Gly Arg Gly Glu Arg 
            420                 425                 430         


Ala Gln Leu Arg Arg Cys Thr Asp Ala Asp Glu Leu Leu Thr Gln Ser 
        435                 440                 445             


Ala Thr Leu Leu Leu Ala His Arg Leu Val Ala Leu Asn Gly Glu Arg 
    450                 455                 460                 


Gly Pro Leu Pro Asp Asn Ser Leu Ser Tyr Glu Arg Met Ala Trp Val 
465                 470                 475                 480 


Ala Gly Val Leu Ala Asn Val Lys Asp Asp Leu Arg Asp Gly Lys Ser 
                485                 490                 495     


Leu Ala Thr His Leu Gly Gln Ala Ala Asp Ala Glu Arg Pro Pro Met 
            500                 505                 510         


Ser Glu Leu Arg Phe Arg Ala Met Gln Arg Gly Thr Ala Met Gln Glu 
        515                 520                 525             


Leu Phe Leu His Trp Arg Arg Ala Leu Gln Leu Ala Gly Gly Lys Thr 
    530                 535                 540                 


Asp Val Ala His Leu Ala Asp Asp Leu Leu Ser Trp Gln Ile Glu Gln 
545                 550                 555                 560 


Gly Gln Ser Ala Ala Gln Ala Ser Asn Gly Val Lys Phe His Trp Ala 
                565                 570                 575     


Tyr Asp Tyr Tyr Leu Ser Ala Arg Asp Arg Ala Ala Ala Lys Glu Pro 
            580                 585                 590         


Glu Phe Asn Lys Glu Ile Ser Lys Gly Ser Gly Glu Gly Arg Gly Ser 
        595                 600                 605             


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys 
    610                 615                 620                 


Lys Arg Lys Val Gly Ser Gly Met Thr Asp Tyr Leu Leu Leu Arg Leu 
625                 630                 635                 640 


Tyr Gly Pro Leu Ala Ser Trp Gly Glu Ile Ala Val Gly Glu Ser Arg 
                645                 650                 655     


His Ser Ala Val Gln Pro Ser Arg Ser Ala Leu Leu Gly Leu Leu Gly 
            660                 665                 670         


Ala Ala Leu Gly Ile Glu Arg His Asp Asp Ala Ala Gln Gln Ala Leu 
        675                 680                 685             


Val Asp Gly Tyr Arg Phe Ala Ile Lys Leu Glu Cys Ile Gly Ser Pro 
    690                 695                 700                 


Leu Arg Asp Tyr His Thr Val Gln Val Gly Val Pro Pro Arg Lys Phe 
705                 710                 715                 720 


Gln Phe Arg Ser Arg Arg Gln Glu Leu Ala Ala Asp Lys Val Asp Thr 
                725                 730                 735     


Ile Leu Ser Thr Arg Glu Tyr Arg Cys Asp Ser Leu Ala Leu Val Ala 
            740                 745                 750         


Val Glu Ala Leu Pro Gly Ala Pro Val Asp Leu Ala Ser Leu Ala Glu 
        755                 760                 765             


Ala Leu Arg Lys Pro Arg Phe Ala Leu Tyr Leu Gly Arg Lys Ser Cys 
    770                 775                 780                 


Pro Leu Ala Leu Pro Leu Ser Pro Lys Ile Leu Ala Ala Ser Ser Val 
785                 790                 795                 800 


Arg Glu Val Phe Asp Asn Leu Glu Leu Pro Ser Leu Leu Gly Leu Leu 
                805                 810                 815     


Asp Arg Tyr Gln Pro Glu Gln Ala Trp Pro Ser Arg Gln Asp Gln Gln 
            820                 825                 830         


Ala Leu Arg Pro Gly Val Ala Arg Tyr Tyr Trp Glu Asp Gly Met Thr 
        835                 840                 845             


Ala Gly Met Ala Pro Ser Phe Glu Ala Gln Arg His Asp Gln Pro Leu 
    850                 855                 860                 


Ser Arg Arg Arg Trp Gln Phe Ala Pro Arg Arg Glu Trp Val Ala Leu 
865                 870                 875                 880 


Asn Asp Gly Gly Gln Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
                885                 890                 895     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
            900                 905                 910         


Lys Val Gly Ser Gly Met Ser His Tyr Phe Ser Leu Val Arg Leu Ile 
        915                 920                 925             


Gly Ser Pro Arg His Asp Ala Trp Leu Arg Asp Leu Ser Arg His Gly 
    930                 935                 940                 


Glu Ala Tyr Arg Asp His Ala Leu Ile Trp Arg Leu Phe Pro Gly Asp 
945                 950                 955                 960 


Gly Ala Ala Arg Asp Phe Val Phe Arg Arg Leu Glu Asp Glu Lys Ser 
                965                 970                 975     


Phe Tyr Val Val Ser Ala Arg Pro Pro Gln Ala Asp Ala Gly Leu Phe 
            980                 985                 990         


His Ile Gln Ser Lys Ala Tyr Ser  Pro Glu Leu Ala Glu  Gly Asp Trp 
        995                 1000                 1005             


Val Arg  Phe Asp Leu Arg Ala  Asn Pro Thr Val Ser  Val Arg Arg 
    1010                 1015                 1020             


Glu Asn  Gly Arg Ser Gln Arg  His Asp Val Leu Met  His Ala Lys 
    1025                 1030                 1035             


Gln Leu  Ala Ser Thr Glu Lys  Ser Ala Leu Pro Glu  Arg Leu Glu 
    1040                 1045                 1050             


Ala Ala  Gly Arg Glu Trp Leu  Lys Asp Arg Ala Glu  Arg Trp Gly 
    1055                 1060                 1065             


Leu Asp  Leu Arg Thr Asp Ser  Leu Met Gln Asn Gly  Tyr Arg Gln 
    1070                 1075                 1080             


Gln Arg  Leu Lys Arg Lys Gly  Lys His Ile Ala Phe  Ser Thr Leu 
    1085                 1090                 1095             


Asp Tyr  Gln Gly Ile Ala Gln  Val Thr Asp Pro Glu  Gln Leu Arg 
    1100                 1105                 1110             


Arg Ala  Leu Leu Asp Gly Val  Gly His Ser Lys Gly  Phe Gly Cys 
    1115                 1120                 1125             


Gly Leu  Leu Leu Val Lys Arg  Val Asp Gly Ser Gly  Glu Gly Arg 
    1130                 1135                 1140             


Gly Ser  Leu Leu Thr Cys Gly  Asp Val Glu Glu Asn  Pro Gly Pro 
    1145                 1150                 1155             


Pro Lys  Lys Lys Arg Lys Val  Gly Gly Ser Met Asp  Leu Leu Ser 
    1160                 1165                 1170             


Asp Thr  Trp Leu Gln Cys Arg  His Arg Asp Gly Thr  Leu Lys Pro 
    1175                 1180                 1185             


Ile Ala  Ile Gly Gln Ile Gly  Leu Glu Asp Cys Leu  Glu Leu Val 
    1190                 1195                 1200             


Ala Pro  Arg Pro Asp Phe Arg  Gly Ala Leu Tyr Gln  Phe Leu Ile 
    1205                 1210                 1215             


Gly Leu  Leu Gln Thr Ala Tyr  Ala Pro Glu Asp Leu  Gln Glu Trp 
    1220                 1225                 1230             


Arg Asp  Arg Tyr Ala Asn Pro  Pro Thr Ala Asp Asp  Leu Ala Glu 
    1235                 1240                 1245             


Val Phe  Ala Pro Tyr Arg Asp  Ala Phe Gln Leu Glu  Asn Ser Gly 
    1250                 1255                 1260             


Pro Thr  Phe Met Gln Asp Leu  Thr Leu Pro Asp Asp  Val Asn Gln 
    1265                 1270                 1275             


Leu Pro  Val Leu Glu Leu Leu  Ile Asp Ala Gly Ser  Ser Ser Asn 
    1280                 1285                 1290             


Gln Tyr  Phe Asn Lys Pro Ala  Val Glu His Gly Met  Cys Glu Gly 
    1295                 1300                 1305             


Cys Phe  Thr Gln Ala Leu Leu  Thr Met Gln Leu Asn  Ala Pro Ser 
    1310                 1315                 1320             


Gly Gly  Arg Gly Ile Arg Thr  Ser Leu Arg Gly Gly  Gly Pro Leu 
    1325                 1330                 1335             


Thr Thr  Leu Leu Val Pro Ala  Glu Gln Asn Ala Thr  Leu Trp Gln 
    1340                 1345                 1350             


Lys Leu  Trp Leu Asn Val Leu  Pro Leu Asp Ala Leu  Asp His Pro 
    1355                 1360                 1365             


Pro Ile  Lys Met Leu Ser Asp  Val Leu Pro Trp Leu  Ala Pro Thr 
    1370                 1375                 1380             


Arg Thr  Ser Asp Asp Lys Gln  Gly Gln Asp Thr Pro  Pro Glu Ser 
    1385                 1390                 1395             


Val His  Pro Leu Gln Ala Tyr  Trp Ser Met Pro Arg  Arg Ile Arg 
    1400                 1405                 1410             


Leu Asp  Ala Ala Thr Leu Asp  Gln Gly Asp Cys Ala  Val Cys Gly 
    1415                 1420                 1425             


Ala Gln  Asn Val Lys Arg Ile  Arg His Tyr Arg Thr  Arg His Gly 
    1430                 1435                 1440             


Gly Thr  Asn Tyr Thr Gly Thr  Trp Thr His Pro Leu  Thr Pro Tyr 
    1445                 1450                 1455             


Ser Leu  Asp Ser Lys Gly Glu  Lys Pro Pro Leu Ser  Ile Lys Gly 
    1460                 1465                 1470             


Arg Gln  Ala Gly Arg Gly Tyr  Arg Asp Trp Leu Gly  Leu Val Leu 
    1475                 1480                 1485             


Gly Asn  Glu Asp His Gln Pro  Asp Ala Ala Gln Val  Val Arg His 
    1490                 1495                 1500             


Phe Thr  Ala Lys Leu Gly Lys  Pro Ser Val Arg Leu  Trp Cys Phe 
    1505                 1510                 1515             


Gly Phe  Asp Met Ser Asn Met  Lys Ala Leu Cys Trp  Tyr Asp Ser 
    1520                 1525                 1530             


Leu Leu  Pro Val His Gly Val  Ala Pro Asp Val Gln  Arg Lys Phe 
    1535                 1540                 1545             


Thr Arg  Ser Val Lys Gln Val  Leu Asp Ser Ala Asn  Asp Met Ala 
    1550                 1555                 1560             


Ser Val  Leu His Lys Gln Val  Lys Ala Ala Trp Phe  Arg Arg Pro 
    1565                 1570                 1575             


Gly Asp  Ala Gly Gln Glu Pro  Ala Val Thr Gln Ser  Phe Trp Gln 
    1580                 1585                 1590             


Gly Ser  Glu Thr Ala Phe Tyr  Gln Val Leu Glu Gln  Leu Ser Lys 
    1595                 1600                 1605             


Leu Asp  Phe Asp Ser Ala Ala  Glu Leu Ala Ala Ile  Tyr Arg Ala 
    1610                 1615                 1620             


Trp Leu  Gln Ala Thr Arg Arg  Leu Val Leu Ser Leu  Phe Asp His 
    1625                 1630                 1635             


Trp Val  Leu Ser Gly Pro Leu  Glu Asp Met Asp Met  Gln Arg Val 
    1640                 1645                 1650             


Val Lys  Ala Arg Ala Asp Leu  Ala Lys Glu Leu Asn  Thr Gly Lys 
    1655                 1660                 1665             


Ala Gln  Lys Pro Leu Trp Thr  Ile Val Asn Gln His  Leu Lys Glu 
    1670                 1675                 1680             


Gln Ala  
    1685 


<210>  1919
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D448A Cas3 variant (mCas3)

<400>  1919

Met Pro Asn Gln Ala Ser Tyr Phe Ser Tyr Trp Gly Lys Ala Ser Pro 
1               5                   10                  15      


Leu Ser Gln Ala Gly Glu Arg Phe His Leu Leu Pro Phe His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Cys Gly Gln Ala Leu Ile Ser Leu Pro Ser Phe Ser 
        35                  40                  45              


Leu Lys Pro Leu Ala Glu Glu Leu Gly Trp Thr Gln Pro Gln Val Glu 
    50                  55                  60                  


Ser Leu Phe Thr Phe Phe Leu Thr Leu His Asp Leu Gly Lys Phe Ala 
65                  70                  75                  80  


Arg Ala Phe Gln Gly Leu Val Pro Asp Leu Ser Pro Asp Leu Val Pro 
                85                  90                  95      


Ala Glu Pro Gly Lys Cys Tyr Asp Arg Arg His Asp Thr Leu Gly Trp 
            100                 105                 110         


Leu Leu Trp Ser Gln Asp Leu Ala Ala Asp Asp Pro Ile Asp Asn Leu 
        115                 120                 125             


Pro Gln Pro Glu His Glu Phe Trp Ala Val Trp Val Arg Ser Val Val 
    130                 135                 140                 


Gly His His Gly Lys Pro Pro Glu Glu Val Ala Asp Ala Gly Leu Thr 
145                 150                 155                 160 


Ala Leu Glu Leu Thr Asp Phe Phe Leu Arg Ala Asp Arg Arg Ala Ala 
                165                 170                 175     


Arg Glu Phe Val Gln Ala Leu Ala Gly Trp Met Leu Pro Ala Asp Leu 
            180                 185                 190         


Pro Val Pro Asp Arg Glu Gln Leu Lys Ile Leu Arg Arg His Ala Trp 
        195                 200                 205             


Arg Leu Ala Gly Leu Ala Val Leu Ala Asp Trp Leu Gly Ser Asn Gln 
    210                 215                 220                 


Gly Tyr Phe Pro Tyr Arg Ser Leu Pro Met Ser Leu Pro Glu Tyr Trp 
225                 230                 235                 240 


Glu Leu Ala Arg Gln Gln Ala Glu His Ala Val Ile Ala Ser Gly Leu 
                245                 250                 255     


Arg Trp Gln Pro Leu Arg Pro Trp Ser Asn Pro Leu Glu Leu Phe Asp 
            260                 265                 270         


Tyr Leu Arg Glu Pro Thr Pro Leu Gln Ala Tyr Ala Ala Thr Val Pro 
        275                 280                 285             


Leu Glu His Gly Pro Gln Leu Phe Leu Leu Glu Asp Val Thr Gly Ala 
    290                 295                 300                 


Gly Lys Thr Glu Ala Ala Leu Ile Leu Ala Gln Arg Leu Met Gln Ala 
305                 310                 315                 320 


Asn Leu Ala His Gly Leu Tyr Phe Ala Leu Pro Ser Met Ala Thr Ala 
                325                 330                 335     


Asn Gln Met Tyr Gln Arg Val Gly Gly Val Tyr Arg Arg Leu Tyr Glu 
            340                 345                 350         


Pro Gln Ala Lys Pro Ser Leu Ile Leu Ser His Gly Ala Arg Gln Leu 
        355                 360                 365             


Ile Glu Gly Phe Arg Gln Ser Ile Leu Gln Ser Ala Glu Gln Ala Glu 
    370                 375                 380                 


Asp Cys Arg Tyr Gln Pro Asp Glu Gly Ser Ala Ser Val Gln Cys Asn 
385                 390                 395                 400 


Ala Trp Leu Ala Asp Asn Arg Lys Lys Ala Leu Leu Ala Glu Val Gly 
                405                 410                 415     


Val Gly Thr Leu Asp Gln Ala Leu Leu Ala Val Leu Pro Ala Arg His 
            420                 425                 430         


Gln Ser Leu Arg Leu Leu Gly Leu Ala Gly Lys Val Leu Leu Val Ala 
        435                 440                 445             


Glu Val His Ala Tyr Asp Pro Tyr Met Met Thr Val Leu Lys Thr Leu 
    450                 455                 460                 


Leu Ile Ala His Ala Arg Gln Gly Gly Ser Val Ile Leu Leu Ser Ala 
465                 470                 475                 480 


Thr Leu Pro Leu Ala Ala Arg Glu Glu Leu Leu Ala Ala Tyr Arg Phe 
                485                 490                 495     


Gly Leu Gly Val Thr Ala Glu Thr Val Val Asp Asp Arg Arg Tyr Pro 
            500                 505                 510         


Leu Ala Thr Gln Ala Gly Lys Ser Leu Asn Ser His Ala Cys Glu Thr 
        515                 520                 525             


Arg Pro Gln Leu Arg Arg Ser Val Ala Val Arg Pro Leu His Asp Glu 
    530                 535                 540                 


Ala Ser Val Val Glu Leu Ile Val Ala Gln Ala Arg Val Gly Arg Cys 
545                 550                 555                 560 


Val Cys Trp Ile Arg Asn Thr Val Asp Asp Ala Arg Arg Ala Asn Gln 
                565                 570                 575     


Leu Leu Ala Glu His Leu Pro Glu Glu Gln Arg Ile Leu Phe His Ser 
            580                 585                 590         


Arg Phe Ala Met Gly His Arg Leu Asp Ile Glu Ala Gln Val Leu Ala 
        595                 600                 605             


Arg Phe Gly Lys Ala Ser Thr Gly Gln Val Arg Ala Gly Gln Val Leu 
    610                 615                 620                 


Val Gly Thr Gln Val Leu Glu Gln Ser Leu Asp Phe Asp Val Asp Leu 
625                 630                 635                 640 


Met Val Ser Asp Leu Ala Pro Val Asp Leu Leu Ile Gln Arg Ala Gly 
                645                 650                 655     


Arg Leu Gln Arg His Ala Arg Gln Ala Ser Gly Asp Leu Ala Val Asp 
            660                 665                 670         


Ala Val Glu Arg Arg Glu Pro Pro Val Leu Tyr Leu Leu Thr Pro Glu 
        675                 680                 685             


Pro Val Glu Asn Pro Pro Ala Asp Trp Tyr Ala Ser Leu Phe Pro Lys 
    690                 695                 700                 


Ala Cys Tyr Val Tyr Pro Asp Ala Gly Arg Leu Trp Leu Gly Ala Arg 
705                 710                 715                 720 


Ala Leu Leu Gln Ala Gly Cys Ile Val Thr Pro Gly Glu Gln Gly Gln 
                725                 730                 735     


Thr Gly Ala Val Arg Glu Leu Val Glu Ala Val Tyr Gly Ser Glu Val 
            740                 745                 750         


Asp Asp Val Pro Asn Ala Leu Lys Lys Ala Ser Gln Asp Gln Leu Gly 
        755                 760                 765             


Lys Asp Met Ala Met Gln Ser Gln Ala His Phe Asn Gly Leu Arg Leu 
    770                 775                 780                 


Asp Lys Gly Tyr Cys Ile Asp Ser Ser Ala Arg Trp Tyr Glu Asp His 
785                 790                 795                 800 


Ala Val Pro Thr Arg Leu Gly Asp Glu Thr Gln Ala Leu Tyr Leu Ala 
                805                 810                 815     


Leu Trp Thr Asp Gly Glu Leu Gln Pro Leu Cys Ala Asp Ala Ala Tyr 
            820                 825                 830         


Pro Trp Glu Glu Ser Ala Val Arg Ile Ala Ala His Arg Ala Arg Glu 
        835                 840                 845             


Leu Ala Pro Asp Trp Gln Gln Gln Phe Ala Ala Pro Leu Glu Gln Leu 
    850                 855                 860                 


Arg Asn Arg Tyr Arg Leu Leu Glu Glu Pro Ala Phe Ile Leu Pro Leu 
865                 870                 875                 880 


Val Thr Ser Gly Thr Ala Leu Val Gly Lys Val Leu Asp Glu Lys Gly 
                885                 890                 895     


Arg Val Leu Asp Met Arg Tyr Asp Arg Gln Gln Gly Leu Ser Trp 
            900                 905                 910     


<210>  1920
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D75A Cas3 variant (dCas3)

<400>  1920

Met Pro Asn Gln Ala Ser Tyr Phe Ser Tyr Trp Gly Lys Ala Ser Pro 
1               5                   10                  15      


Leu Ser Gln Ala Gly Glu Arg Phe His Leu Leu Pro Phe His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Cys Gly Gln Ala Leu Ile Ser Leu Pro Ser Phe Ser 
        35                  40                  45              


Leu Lys Pro Leu Ala Glu Glu Leu Gly Trp Thr Gln Pro Gln Val Glu 
    50                  55                  60                  


Ser Leu Phe Thr Phe Phe Leu Thr Leu His Ala Leu Gly Lys Phe Ala 
65                  70                  75                  80  


Arg Ala Phe Gln Gly Leu Val Pro Asp Leu Ser Pro Asp Leu Val Pro 
                85                  90                  95      


Ala Glu Pro Gly Lys Cys Tyr Asp Arg Arg His Asp Thr Leu Gly Trp 
            100                 105                 110         


Leu Leu Trp Ser Gln Asp Leu Ala Ala Asp Asp Pro Ile Asp Asn Leu 
        115                 120                 125             


Pro Gln Pro Glu His Glu Phe Trp Ala Val Trp Val Arg Ser Val Val 
    130                 135                 140                 


Gly His His Gly Lys Pro Pro Glu Glu Val Ala Asp Ala Gly Leu Thr 
145                 150                 155                 160 


Ala Leu Glu Leu Thr Asp Phe Phe Leu Arg Ala Asp Arg Arg Ala Ala 
                165                 170                 175     


Arg Glu Phe Val Gln Ala Leu Ala Gly Trp Met Leu Pro Ala Asp Leu 
            180                 185                 190         


Pro Val Pro Asp Arg Glu Gln Leu Lys Ile Leu Arg Arg His Ala Trp 
        195                 200                 205             


Arg Leu Ala Gly Leu Ala Val Leu Ala Asp Trp Leu Gly Ser Asn Gln 
    210                 215                 220                 


Gly Tyr Phe Pro Tyr Arg Ser Leu Pro Met Ser Leu Pro Glu Tyr Trp 
225                 230                 235                 240 


Glu Leu Ala Arg Gln Gln Ala Glu His Ala Val Ile Ala Ser Gly Leu 
                245                 250                 255     


Arg Trp Gln Pro Leu Arg Pro Trp Ser Asn Pro Leu Glu Leu Phe Asp 
            260                 265                 270         


Tyr Leu Arg Glu Pro Thr Pro Leu Gln Ala Tyr Ala Ala Thr Val Pro 
        275                 280                 285             


Leu Glu His Gly Pro Gln Leu Phe Leu Leu Glu Asp Val Thr Gly Ala 
    290                 295                 300                 


Gly Lys Thr Glu Ala Ala Leu Ile Leu Ala Gln Arg Leu Met Gln Ala 
305                 310                 315                 320 


Asn Leu Ala His Gly Leu Tyr Phe Ala Leu Pro Ser Met Ala Thr Ala 
                325                 330                 335     


Asn Gln Met Tyr Gln Arg Val Gly Gly Val Tyr Arg Arg Leu Tyr Glu 
            340                 345                 350         


Pro Gln Ala Lys Pro Ser Leu Ile Leu Ser His Gly Ala Arg Gln Leu 
        355                 360                 365             


Ile Glu Gly Phe Arg Gln Ser Ile Leu Gln Ser Ala Glu Gln Ala Glu 
    370                 375                 380                 


Asp Cys Arg Tyr Gln Pro Asp Glu Gly Ser Ala Ser Val Gln Cys Asn 
385                 390                 395                 400 


Ala Trp Leu Ala Asp Asn Arg Lys Lys Ala Leu Leu Ala Glu Val Gly 
                405                 410                 415     


Val Gly Thr Leu Asp Gln Ala Leu Leu Ala Val Leu Pro Ala Arg His 
            420                 425                 430         


Gln Ser Leu Arg Leu Leu Gly Leu Ala Gly Lys Val Leu Leu Val Asp 
        435                 440                 445             


Glu Val His Ala Tyr Asp Pro Tyr Met Met Thr Val Leu Lys Thr Leu 
    450                 455                 460                 


Leu Ile Ala His Ala Arg Gln Gly Gly Ser Val Ile Leu Leu Ser Ala 
465                 470                 475                 480 


Thr Leu Pro Leu Ala Ala Arg Glu Glu Leu Leu Ala Ala Tyr Arg Phe 
                485                 490                 495     


Gly Leu Gly Val Thr Ala Glu Thr Val Val Asp Asp Arg Arg Tyr Pro 
            500                 505                 510         


Leu Ala Thr Gln Ala Gly Lys Ser Leu Asn Ser His Ala Cys Glu Thr 
        515                 520                 525             


Arg Pro Gln Leu Arg Arg Ser Val Ala Val Arg Pro Leu His Asp Glu 
    530                 535                 540                 


Ala Ser Val Val Glu Leu Ile Val Ala Gln Ala Arg Val Gly Arg Cys 
545                 550                 555                 560 


Val Cys Trp Ile Arg Asn Thr Val Asp Asp Ala Arg Arg Ala Asn Gln 
                565                 570                 575     


Leu Leu Ala Glu His Leu Pro Glu Glu Gln Arg Ile Leu Phe His Ser 
            580                 585                 590         


Arg Phe Ala Met Gly His Arg Leu Asp Ile Glu Ala Gln Val Leu Ala 
        595                 600                 605             


Arg Phe Gly Lys Ala Ser Thr Gly Gln Val Arg Ala Gly Gln Val Leu 
    610                 615                 620                 


Val Gly Thr Gln Val Leu Glu Gln Ser Leu Asp Phe Asp Val Asp Leu 
625                 630                 635                 640 


Met Val Ser Asp Leu Ala Pro Val Asp Leu Leu Ile Gln Arg Ala Gly 
                645                 650                 655     


Arg Leu Gln Arg His Ala Arg Gln Ala Ser Gly Asp Leu Ala Val Asp 
            660                 665                 670         


Ala Val Glu Arg Arg Glu Pro Pro Val Leu Tyr Leu Leu Thr Pro Glu 
        675                 680                 685             


Pro Val Glu Asn Pro Pro Ala Asp Trp Tyr Ala Ser Leu Phe Pro Lys 
    690                 695                 700                 


Ala Cys Tyr Val Tyr Pro Asp Ala Gly Arg Leu Trp Leu Gly Ala Arg 
705                 710                 715                 720 


Ala Leu Leu Gln Ala Gly Cys Ile Val Thr Pro Gly Glu Gln Gly Gln 
                725                 730                 735     


Thr Gly Ala Val Arg Glu Leu Val Glu Ala Val Tyr Gly Ser Glu Val 
            740                 745                 750         


Asp Asp Val Pro Asn Ala Leu Lys Lys Ala Ser Gln Asp Gln Leu Gly 
        755                 760                 765             


Lys Asp Met Ala Met Gln Ser Gln Ala His Phe Asn Gly Leu Arg Leu 
    770                 775                 780                 


Asp Lys Gly Tyr Cys Ile Asp Ser Ser Ala Arg Trp Tyr Glu Asp His 
785                 790                 795                 800 


Ala Val Pro Thr Arg Leu Gly Asp Glu Thr Gln Ala Leu Tyr Leu Ala 
                805                 810                 815     


Leu Trp Thr Asp Gly Glu Leu Gln Pro Leu Cys Ala Asp Ala Ala Tyr 
            820                 825                 830         


Pro Trp Glu Glu Ser Ala Val Arg Ile Ala Ala His Arg Ala Arg Glu 
        835                 840                 845             


Leu Ala Pro Asp Trp Gln Gln Gln Phe Ala Ala Pro Leu Glu Gln Leu 
    850                 855                 860                 


Arg Asn Arg Tyr Arg Leu Leu Glu Glu Pro Ala Phe Ile Leu Pro Leu 
865                 870                 875                 880 


Val Thr Ser Gly Thr Ala Leu Val Gly Lys Val Leu Asp Glu Lys Gly 
                885                 890                 895     


Arg Val Leu Asp Met Arg Tyr Asp Arg Gln Gln Gly Leu Ser Trp 
            900                 905                 910     


<210>  1921
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D448A D75A Cas3 variant (dblmCas3)

<400>  1921

Met Pro Asn Gln Ala Ser Tyr Phe Ser Tyr Trp Gly Lys Ala Ser Pro 
1               5                   10                  15      


Leu Ser Gln Ala Gly Glu Arg Phe His Leu Leu Pro Phe His Cys Leu 
            20                  25                  30          


Asp Val Ala Ala Cys Gly Gln Ala Leu Ile Ser Leu Pro Ser Phe Ser 
        35                  40                  45              


Leu Lys Pro Leu Ala Glu Glu Leu Gly Trp Thr Gln Pro Gln Val Glu 
    50                  55                  60                  


Ser Leu Phe Thr Phe Phe Leu Thr Leu His Ala Leu Gly Lys Phe Ala 
65                  70                  75                  80  


Arg Ala Phe Gln Gly Leu Val Pro Asp Leu Ser Pro Asp Leu Val Pro 
                85                  90                  95      


Ala Glu Pro Gly Lys Cys Tyr Asp Arg Arg His Asp Thr Leu Gly Trp 
            100                 105                 110         


Leu Leu Trp Ser Gln Asp Leu Ala Ala Asp Asp Pro Ile Asp Asn Leu 
        115                 120                 125             


Pro Gln Pro Glu His Glu Phe Trp Ala Val Trp Val Arg Ser Val Val 
    130                 135                 140                 


Gly His His Gly Lys Pro Pro Glu Glu Val Ala Asp Ala Gly Leu Thr 
145                 150                 155                 160 


Ala Leu Glu Leu Thr Asp Phe Phe Leu Arg Ala Asp Arg Arg Ala Ala 
                165                 170                 175     


Arg Glu Phe Val Gln Ala Leu Ala Gly Trp Met Leu Pro Ala Asp Leu 
            180                 185                 190         


Pro Val Pro Asp Arg Glu Gln Leu Lys Ile Leu Arg Arg His Ala Trp 
        195                 200                 205             


Arg Leu Ala Gly Leu Ala Val Leu Ala Asp Trp Leu Gly Ser Asn Gln 
    210                 215                 220                 


Gly Tyr Phe Pro Tyr Arg Ser Leu Pro Met Ser Leu Pro Glu Tyr Trp 
225                 230                 235                 240 


Glu Leu Ala Arg Gln Gln Ala Glu His Ala Val Ile Ala Ser Gly Leu 
                245                 250                 255     


Arg Trp Gln Pro Leu Arg Pro Trp Ser Asn Pro Leu Glu Leu Phe Asp 
            260                 265                 270         


Tyr Leu Arg Glu Pro Thr Pro Leu Gln Ala Tyr Ala Ala Thr Val Pro 
        275                 280                 285             


Leu Glu His Gly Pro Gln Leu Phe Leu Leu Glu Asp Val Thr Gly Ala 
    290                 295                 300                 


Gly Lys Thr Glu Ala Ala Leu Ile Leu Ala Gln Arg Leu Met Gln Ala 
305                 310                 315                 320 


Asn Leu Ala His Gly Leu Tyr Phe Ala Leu Pro Ser Met Ala Thr Ala 
                325                 330                 335     


Asn Gln Met Tyr Gln Arg Val Gly Gly Val Tyr Arg Arg Leu Tyr Glu 
            340                 345                 350         


Pro Gln Ala Lys Pro Ser Leu Ile Leu Ser His Gly Ala Arg Gln Leu 
        355                 360                 365             


Ile Glu Gly Phe Arg Gln Ser Ile Leu Gln Ser Ala Glu Gln Ala Glu 
    370                 375                 380                 


Asp Cys Arg Tyr Gln Pro Asp Glu Gly Ser Ala Ser Val Gln Cys Asn 
385                 390                 395                 400 


Ala Trp Leu Ala Asp Asn Arg Lys Lys Ala Leu Leu Ala Glu Val Gly 
                405                 410                 415     


Val Gly Thr Leu Asp Gln Ala Leu Leu Ala Val Leu Pro Ala Arg His 
            420                 425                 430         


Gln Ser Leu Arg Leu Leu Gly Leu Ala Gly Lys Val Leu Leu Val Ala 
        435                 440                 445             


Glu Val His Ala Tyr Asp Pro Tyr Met Met Thr Val Leu Lys Thr Leu 
    450                 455                 460                 


Leu Ile Ala His Ala Arg Gln Gly Gly Ser Val Ile Leu Leu Ser Ala 
465                 470                 475                 480 


Thr Leu Pro Leu Ala Ala Arg Glu Glu Leu Leu Ala Ala Tyr Arg Phe 
                485                 490                 495     


Gly Leu Gly Val Thr Ala Glu Thr Val Val Asp Asp Arg Arg Tyr Pro 
            500                 505                 510         


Leu Ala Thr Gln Ala Gly Lys Ser Leu Asn Ser His Ala Cys Glu Thr 
        515                 520                 525             


Arg Pro Gln Leu Arg Arg Ser Val Ala Val Arg Pro Leu His Asp Glu 
    530                 535                 540                 


Ala Ser Val Val Glu Leu Ile Val Ala Gln Ala Arg Val Gly Arg Cys 
545                 550                 555                 560 


Val Cys Trp Ile Arg Asn Thr Val Asp Asp Ala Arg Arg Ala Asn Gln 
                565                 570                 575     


Leu Leu Ala Glu His Leu Pro Glu Glu Gln Arg Ile Leu Phe His Ser 
            580                 585                 590         


Arg Phe Ala Met Gly His Arg Leu Asp Ile Glu Ala Gln Val Leu Ala 
        595                 600                 605             


Arg Phe Gly Lys Ala Ser Thr Gly Gln Val Arg Ala Gly Gln Val Leu 
    610                 615                 620                 


Val Gly Thr Gln Val Leu Glu Gln Ser Leu Asp Phe Asp Val Asp Leu 
625                 630                 635                 640 


Met Val Ser Asp Leu Ala Pro Val Asp Leu Leu Ile Gln Arg Ala Gly 
                645                 650                 655     


Arg Leu Gln Arg His Ala Arg Gln Ala Ser Gly Asp Leu Ala Val Asp 
            660                 665                 670         


Ala Val Glu Arg Arg Glu Pro Pro Val Leu Tyr Leu Leu Thr Pro Glu 
        675                 680                 685             


Pro Val Glu Asn Pro Pro Ala Asp Trp Tyr Ala Ser Leu Phe Pro Lys 
    690                 695                 700                 


Ala Cys Tyr Val Tyr Pro Asp Ala Gly Arg Leu Trp Leu Gly Ala Arg 
705                 710                 715                 720 


Ala Leu Leu Gln Ala Gly Cys Ile Val Thr Pro Gly Glu Gln Gly Gln 
                725                 730                 735     


Thr Gly Ala Val Arg Glu Leu Val Glu Ala Val Tyr Gly Ser Glu Val 
            740                 745                 750         


Asp Asp Val Pro Asn Ala Leu Lys Lys Ala Ser Gln Asp Gln Leu Gly 
        755                 760                 765             


Lys Asp Met Ala Met Gln Ser Gln Ala His Phe Asn Gly Leu Arg Leu 
    770                 775                 780                 


Asp Lys Gly Tyr Cys Ile Asp Ser Ser Ala Arg Trp Tyr Glu Asp His 
785                 790                 795                 800 


Ala Val Pro Thr Arg Leu Gly Asp Glu Thr Gln Ala Leu Tyr Leu Ala 
                805                 810                 815     


Leu Trp Thr Asp Gly Glu Leu Gln Pro Leu Cys Ala Asp Ala Ala Tyr 
            820                 825                 830         


Pro Trp Glu Glu Ser Ala Val Arg Ile Ala Ala His Arg Ala Arg Glu 
        835                 840                 845             


Leu Ala Pro Asp Trp Gln Gln Gln Phe Ala Ala Pro Leu Glu Gln Leu 
    850                 855                 860                 


Arg Asn Arg Tyr Arg Leu Leu Glu Glu Pro Ala Phe Ile Leu Pro Leu 
865                 870                 875                 880 


Val Thr Ser Gly Thr Ala Leu Val Gly Lys Val Leu Asp Glu Lys Gly 
                885                 890                 895     


Arg Val Leu Asp Met Arg Tyr Asp Arg Gln Gln Gly Leu Ser Trp 
            900                 905                 910     


<210>  1922
<211>  933
<212>  PRT
<213>  Thermomonospora curvata

<400>  1922

Met Trp Gly Lys Arg Asp Gly Leu Pro Gly Pro Tyr Pro Val Val Cys 
1               5                   10                  15      


His Leu Ile Asp Thr Ala Ala Ile Ala Gly Ala Leu Trp Asp Val Trp 
            20                  25                  30          


Thr Ala Gly Leu Gly Val Leu Arg Ala Asp Val Leu Gly Glu Arg Val 
        35                  40                  45              


Ala Ala His Met Arg Ser Leu Val Cys Phe Trp Ala Gly Leu His Asp 
    50                  55                  60                  


Ile Gly Lys Val Ser Pro Ser Phe Gln Val Leu Val Gly Asp Leu Tyr 
65                  70                  75                  80  


Gln Lys Leu Val Thr Glu Ala Ser Glu Tyr Glu Gln Asp Glu Ala Ile 
                85                  90                  95      


Ser Gly Leu Arg His Asn Glu Val Thr Gln Trp Val Leu Val Glu Ile 
            100                 105                 110         


Phe Arg Ala Leu Gly Tyr Pro Ala Ala Asp Ser Ala Arg Arg Asp Val 
        115                 120                 125             


Gly His Gln Ile Ala Gln Leu Leu Gly Gly His His Gly Arg Phe Cys 
    130                 135                 140                 


Ala Ala Met Arg Arg Pro Glu Leu Arg Ala Pro Arg Ser Arg Pro Gly 
145                 150                 155                 160 


Val Gly Arg Gly Val Trp Glu Glu Gln Cys Arg Ala His Ala Ala Val 
                165                 170                 175     


Leu Arg Glu Leu Thr Gly Ala Arg Glu Val Leu Arg Glu Arg Leu Pro 
            180                 185                 190         


Val Pro Val Ala Val Val Val Leu Gly Ile Val Ile Val Ala Asp Trp 
        195                 200                 205             


Leu Ala Ser Gln Glu Ser Phe Ile Val Ala Arg Met Pro Gly Glu Gly 
    210                 215                 220                 


Trp Glu Ala Ser Pro Glu Glu Leu Arg Ala His Trp Glu Arg Ala Val 
225                 230                 235                 240 


Ala Asp Ala Pro Gln Val Val Arg Asp Ala Gly Leu Gly Arg Gly Leu 
                245                 250                 255     


Leu Glu Asp Arg Thr Phe Arg Glu Leu Phe Gly Phe Asp Glu Pro Asn 
            260                 265                 270         


Pro Leu Gln Ala Ser Val Met Lys Glu Leu Pro Glu Leu Val Asn Gly 
        275                 280                 285             


Pro Gly Leu Val Leu Cys Thr Ala Pro Pro Gly Asp Gly Lys Thr Glu 
    290                 295                 300                 


Ala Ala Leu Tyr Ala Ala Gly Val Leu Ala Arg Ala Cys Gly Ala Asn 
305                 310                 315                 320 


Gly Leu Gly Phe Cys Leu Pro Thr Met Ala Thr Thr Asp Ala Met His 
                325                 330                 335     


Lys Arg Val Ser Arg Phe Ala Arg Arg Ala Leu Arg Glu Asp Ala Ala 
            340                 345                 350         


Leu Thr Lys Val His Ser Met Ala Trp Leu Ser Ser Asp Ala Ala Gly 
        355                 360                 365             


Asp Ala Ala Ala Gly Ala Ala Gly Gly Asp Ala Val Ile Thr Asp Ala 
    370                 375                 380                 


Glu Ala Ser Thr Glu Ala Ala Gln Trp Leu His Ala Gly Arg Arg Gly 
385                 390                 395                 400 


Leu Leu Ala Pro Leu Thr Thr Phe Thr Ile Asp Gln Gly Leu Thr Gly 
                405                 410                 415     


Val Leu Pro Val Lys Tyr Asn Val Leu Arg Leu Met Ala Met Ala Gly 
            420                 425                 430         


Lys Val Val Val Ile Asp Glu Ala His Ser Tyr Asp Ala Trp Met His 
        435                 440                 445             


Ala Leu Leu Leu Arg Trp Leu Glu Trp Leu Gly Ala Leu Arg Ala Pro 
    450                 455                 460                 


Val Ile Leu Leu Ser Ala Thr Leu Thr Gly Ala Ala Ala Arg Ser Leu 
465                 470                 475                 480 


Val Glu Ala Tyr Leu Arg Gly Ala Gly His Thr Val Pro Gln Glu Leu 
                485                 490                 495     


Arg Pro Cys Tyr Pro Gly Trp Leu Phe Ala Asp Ala Val Thr Gly Thr 
            500                 505                 510         


Val His Pro Pro Arg Glu Val Thr Ser Glu Arg Glu Arg Ala Val Ala 
        515                 520                 525             


Phe Glu Met Val Pro Val Arg Arg Gly Lys Asp Pro Ser Arg Pro Gly 
    530                 535                 540                 


His Arg Leu Ala Val Ile Lys Asp Leu Leu Ala Gln Val Val Asn Gly 
545                 550                 555                 560 


Asp Arg Gly Cys Val Leu Val Cys Cys Thr Thr Val Pro Glu Ala Gln 
                565                 570                 575     


Asp Thr Tyr Arg Tyr Leu Ala Asp Trp Phe Arg Arg Val Ala Glu Glu 
            580                 585                 590         


Gly Gly Arg Pro Pro Glu Leu Arg Leu Leu His Ser Arg Tyr Arg Ala 
        595                 600                 605             


Arg Asp Arg Ala Ala Ile Thr Glu Ala Cys Glu Arg Asp Phe Gly Lys 
    610                 615                 620                 


Glu Gly Gly Arg Pro Arg Thr Val Leu Val Ala Thr Gln Ile Val Glu 
625                 630                 635                 640 


Gln Ser Leu Asp Leu Asp Phe Asp Leu Leu Ile Thr Asp Leu Ala Pro 
                645                 650                 655     


Met Ala Leu Leu Leu Gln Arg Ser Gly Arg Cys Gln Arg His Arg Asp 
            660                 665                 670         


Gly Arg Ile Asp Leu His Arg Glu Arg Arg Pro Asp Trp Ala Gly Ala 
        675                 680                 685             


Ala Pro Arg Val Ile Val Leu Asn Pro Val Asp Asp Gln Gly Glu Phe 
    690                 695                 700                 


Ala Val Pro Glu Glu Trp Gly Gly Val Tyr Asp Glu Ser Leu Leu His 
705                 710                 715                 720 


Arg Thr Ser Arg Leu Leu His Ala Arg Gly Ala Glu Pro Val Gln Ile 
                725                 730                 735     


Pro Gly Asp Val Gln Ala Leu Val Asp Ala Val Tyr Ala Glu Asp Phe 
            740                 745                 750         


Thr Ser Val Val Ala Leu Asp Glu Ala Asn Ala Arg Arg Ile Val Arg 
        755                 760                 765             


Ala Asp Gly Glu Arg Leu Gly Gly Glu Ala Ala Gln Arg Gln Thr Ala 
    770                 775                 780                 


Asp Leu Val Met Ile Cys Ser Pro Arg Asp Gly Lys Leu Arg Asp Leu 
785                 790                 795                 800 


Arg Asn Leu Ser Glu Ala Gln Ala Lys Val Ser Ser Ala Trp Leu Thr 
                805                 810                 815     


Thr Arg Leu Gly Ala Asp Ser Glu Arg Leu Val Cys Val Tyr Glu Gln 
            820                 825                 830         


Ser Pro Gly Val Trp Thr Leu Asp Glu Thr Gly Arg Ile Pro Val Pro 
        835                 840                 845             


Gly Met Glu Gly Arg Ser Arg Val Thr Arg Asp Gln Ala Arg Leu Ile 
    850                 855                 860                 


Ala Glu Tyr Met Ile Pro Val Pro Gly Arg Tyr Cys Gly Glu Glu Ala 
865                 870                 875                 880 


Glu Leu Leu Glu Pro Pro Pro Ser Trp Asp Lys Asn Ala Val Leu Arg 
                885                 890                 895     


Asp Trp Lys Leu Leu Pro Met Arg Arg Ala Ser Asp Gly Gly Trp Tyr 
            900                 905                 910         


Gly Arg Leu Arg Pro Gly Gln Val Thr Tyr Gln Ala Asn Val Gly Leu 
        915                 920                 925             


Gln Met Leu Tyr Pro 
    930             


<210>  1923
<211>  953
<212>  PRT
<213>  Streptomyces bottropensis

<400>  1923

Met Gly Val Arg Glu Asp Ala Arg Arg Asp Gly Ile Asn Leu Ser Pro 
1               5                   10                  15      


Trp Gly Lys Phe Asp Arg Gly Glu Arg Ala Val Tyr Ala Leu Leu Phe 
            20                  25                  30          


His Leu Leu Asp Val Ala Ala Leu Ala Gly Ala Val Trp Asp Gly Tyr 
        35                  40                  45              


Leu Thr Arg Gly Gln Arg Arg Leu Ile Ala Ala Gly Leu Gly Leu Thr 
    50                  55                  60                  


Leu Ala Gln Ala Arg Cys Gln Val Met Phe Ile Ala Gly Leu His Asp 
65                  70                  75                  80  


Leu Gly Lys Leu Ser Ala Phe Gln Glu Gln Glu Ala His Pro Trp Ala 
                85                  90                  95      


Arg Val Ser Asp Thr Leu Arg Ser Asp Thr Gly Asn Trp Arg Arg Met 
            100                 105                 110         


Pro His Glu Arg Ala Ser Met His Ser Val Leu His Leu Leu Ala Glu 
        115                 120                 125             


Ala Gly Tyr Pro Ala Asp Thr Ser Asp Ser Pro Gly Val Leu Ile Ala 
    130                 135                 140                 


Gln Ile Leu Gly Gly His His Gly Arg Phe Leu Gln Val Asp Ile Asp 
145                 150                 155                 160 


Gly Ala Ala Lys Ala Ser Arg Val Asn Leu Ala Leu Gly Gly Ser Ala 
                165                 170                 175     


Trp Gln Asp Val Arg Arg Arg Tyr Phe Ala Leu Leu Arg His Leu Thr 
            180                 185                 190         


Gly Ala Thr Ala Val Pro Ser Asp Val Ser Val Pro Ala Ala Val Leu 
        195                 200                 205             


Ile Thr Gly Val Gly Val Ile Ala Asp Arg Leu Ala Ser Gln Arg His 
    210                 215                 220                 


Tyr Trp Leu Pro Lys Ala Gln Ala Pro Ala Phe Gly Ala Gly Glu His 
225                 230                 235                 240 


Phe Ser Leu Ala Val Arg Asp Ala Pro Gly Val Val Glu Glu Ser Gly 
                245                 250                 255     


Leu Val Arg Ile Thr Leu Pro Gln Val Pro Phe Thr Gln Ala His Gly 
            260                 265                 270         


Gly Leu Glu Arg Pro Asn Ala Leu Gln Ala Ser Met Ile Gly Gln Leu 
        275                 280                 285             


Pro Ala Val Val Gly Glu Lys Gly Pro Gly Ile Leu Val Val Thr Asp 
    290                 295                 300                 


Ala Thr Gly Gly Gly Lys Ser Val Thr Ala Leu Glu Ala Ala Arg Ile 
305                 310                 315                 320 


Phe Asn Ala Ser Gly Asp Thr Ser Gly Ile Leu Trp Leu Leu Pro Thr 
                325                 330                 335     


Met Ala Thr Thr Asp Ala Ala Tyr Asp Leu Leu Glu Ala Tyr Val Ala 
            340                 345                 350         


Ala His His Pro Glu His Ala Pro Val Ser Leu Val His Ser His Ser 
        355                 360                 365             


Tyr Asn Asn Thr Ala Tyr Thr Asp His Arg Leu Ala Ala Arg Glu Pro 
    370                 375                 380                 


Ser Thr Ser Asp Ala Tyr Trp Pro Asp Ser Asp Asp Gly Tyr Gly Asp 
385                 390                 395                 400 


Glu Gly Arg Pro Thr Ala Gly Glu Arg Pro Glu Glu Arg Val Thr Val 
                405                 410                 415     


Pro Asp Gly Trp Leu Arg Gly Trp Asp Arg Ala Leu Leu Ala Gln Phe 
            420                 425                 430         


Thr Val Ala Thr His Asp Gln Ala Leu Met Ala Ala Leu Pro Val Arg 
        435                 440                 445             


Phe Ser Ala Leu Arg Met Leu Ala Leu Cys Gly Arg Thr Val Ile Val 
    450                 455                 460                 


Asp Glu Val His Ala Leu Pro Pro Phe Met Arg Gln Thr Leu Ser Arg 
465                 470                 475                 480 


Leu Leu His Trp Leu Gly Ala Leu Gly Cys Pro Val Val Leu Leu Ser 
                485                 490                 495     


Ala Thr Leu Pro Gly His Ile Ser Ser Gln Leu Val Arg Ser Tyr Leu 
            500                 505                 510         


Asp Gly Ala Gly His Pro His Pro Ala Thr Ala His Leu Asp Cys Arg 
        515                 520                 525             


Pro Pro Tyr Pro Gly Trp Leu Tyr Ala Ala Ala Ser Asp Ala Ser Leu 
    530                 535                 540                 


Thr Arg Ile Asp Pro Ala Ala Ala Asp Ala His Ala Asp Arg His Arg 
545                 550                 555                 560 


Arg Arg Ala Asp Leu Arg Leu His Pro Val Arg His Pro Ser Cys Thr 
                565                 570                 575     


Asp Pro Glu Asp Ala Pro Ala Arg Glu Ser Arg Leu Gly Arg Ile Thr 
            580                 585                 590         


Gln Glu Ile Ala Pro Val Ala Arg Ser Gly Gly Cys Ala Ala Val Tyr 
        595                 600                 605             


Cys Ala Thr Met Ala Asp Ala Gln Thr Thr Tyr Ala His Leu Thr Thr 
    610                 615                 620                 


Ala Leu Asn Trp Pro Asp Gly Gly Pro Asp Gly Gln Leu Leu Leu Leu 
625                 630                 635                 640 


His Ala Arg Leu Pro Gly Phe Gln Arg Glu Ala Leu Thr Arg Arg Val 
                645                 650                 655     


Arg Thr Ala Leu Ser Ala Thr Gly Glu Arg Pro Arg Arg Leu Val Val 
            660                 665                 670         


Ile Thr Thr Ser Leu Leu Asp Met Ser Leu Asp Val Asp Val Asp Val 
        675                 680                 685             


Met Val Ser Asp Leu Ala Pro Leu Gln Thr Leu Leu Gln Arg Leu Gly 
    690                 695                 700                 


Arg Leu Trp Arg Phe Asp His Ile Lys Arg Pro Asp Trp Leu Cys Gly 
705                 710                 715                 720 


Asp Val Pro Arg Leu Ile Val Leu Glu Pro Thr Asp His Arg Gly Arg 
                725                 730                 735     


Thr Leu Leu Pro Pro Ala Trp Arg Pro Leu Asp Ser Pro Phe Leu Pro 
            740                 745                 750         


Leu Ala Thr Ala Ala Tyr Leu Ala Arg Arg Pro Glu Gln Pro Leu Thr 
        755                 760                 765             


Leu Pro Asp Asp Val Gln Gln Leu Val Glu Ala Val His Gly Asp Ala 
    770                 775                 780                 


Asp Ala Leu Ala Arg Thr Asp Ala Ala Leu Arg Arg Ser His Thr Leu 
785                 790                 795                 800 


His Gln Ala Arg Thr Arg Thr Glu Glu His His Ser Ala Leu His Leu 
                805                 810                 815     


Val Pro Ala Trp His Asp Thr Leu Ser Leu Ser Asp Leu His Arg Gln 
            820                 825                 830         


Asn Leu His Pro Arg Glu Ala Ala Thr Arg Leu Gly Ala Met Pro Arg 
        835                 840                 845             


Arg Leu Leu Pro Val Tyr Arg Met Ser Gly Gly Arg Leu Thr Leu Asp 
    850                 855                 860                 


Ala Ala Gly Thr Arg Pro Leu Pro Glu His Arg Lys Pro Thr Thr Ala 
865                 870                 875                 880 


Gln Ile Arg Thr Ile Leu Gln His Thr Leu Pro Val Pro Ala Ala Trp 
                885                 890                 895     


Val Ala Gly Arg Thr Arg Asp His His Ile Pro Ala Ser Trp Arg Ser 
            900                 905                 910         


His Ala Leu Leu Ala Asp Leu Val Leu Leu Pro Gln Asp Ala Gly Asp 
        915                 920                 925             


Pro Ser Arg Pro Val Arg Phe Gly Arg His Arg Leu His Leu Asp Asp 
    930                 935                 940                 


Ala Leu Gly Leu Val His Thr Glu Asp 
945                 950             


<210>  1924
<211>  920
<212>  PRT
<213>  Thermus thermophilus

<400>  1924

Met Ser Val Glu Glu Ala Ala Leu Ala Leu Trp Ala Lys Ser Gly Asn 
1               5                   10                  15      


Pro Phe His Pro Leu Leu Ala His Met Leu Asp Thr Ala Ala Val Ala 
            20                  25                  30          


Leu Ala Val Leu Arg Met Glu Pro Pro Arg Thr Arg Ala Leu Tyr Ala 
        35                  40                  45              


Glu Asp Trp Gly Leu Pro Glu Glu Gly Ala Leu Ala Trp Ala Ala Ala 
    50                  55                  60                  


Leu Val Gly Leu His Asp Leu Gly Lys Ala Ser Pro Val Phe Gln Ala 
65                  70                  75                  80  


Gly Trp Glu Glu Gly Lys Glu Arg Val Gln Arg Ala Gly Leu Pro Phe 
                85                  90                  95      


Gly Glu Leu Leu Asp Trp Val Ala His Gly Val Phe Thr Glu Leu Phe 
            100                 105                 110         


Leu Arg Arg Leu Leu Lys Glu Lys Gly Leu Pro Glu Arg Ala Ala Asn 
        115                 120                 125             


Asp Leu Ala Ala Ala Leu Gly Ala His His Gly Phe Pro Ala Asn Ala 
    130                 135                 140                 


Glu Glu Lys Ser Arg Ala Arg Arg His Leu Arg Thr Glu Asp Pro Leu 
145                 150                 155                 160 


Trp Lys Glu Ala Arg Arg Trp Leu Leu Glu Glu Val Phe Arg Arg Leu 
                165                 170                 175     


Gly Ala Pro Leu Pro Pro Ser Gln Gly Asn Gly Glu Ala Arg Pro Glu 
            180                 185                 190         


Ala Val Leu Arg Val Met Ala Leu Ala Ser Phe Ala Asp Trp Val Ala 
        195                 200                 205             


Ser Asp Pro Ser Leu Phe Pro Tyr Gly Arg Asp Pro Arg Arg Gly Asp 
    210                 215                 220                 


Tyr Leu Lys Glu Ala Leu Arg Leu Ala Gln Glu Ala Leu Asn Arg Leu 
225                 230                 235                 240 


Gly Trp Pro Ala Phe Ala Lys Ala Gln Arg Arg Glu Phe Gly Glu Leu 
                245                 250                 255     


Phe Pro Tyr Ile Pro Lys Pro Asn Ala Leu Gln Glu Ser Val Pro Ala 
            260                 265                 270         


Leu Leu Glu Gly Ala Cys Thr Pro Val Leu Leu Leu Val Glu Ala Pro 
        275                 280                 285             


Met Gly Met Gly Lys Thr Glu Ala Ala Leu Tyr Ala His His Leu Leu 
    290                 295                 300                 


Gln Ala Gly Leu Gly His Arg Gly Leu Tyr Val Ala Leu Pro Thr Gln 
305                 310                 315                 320 


Ala Thr Ala Asn Gly Leu Phe Pro Arg Val Arg Gly Phe Leu Glu Arg 
                325                 330                 335     


Leu Gly Glu Gly Ser Arg Leu Glu Leu Gln Leu Gln His Gly Thr Ala 
            340                 345                 350         


Leu Leu Asn Pro His Tyr Ala Gly Leu Leu Glu Arg Ala Ala Pro Arg 
        355                 360                 365             


Gln Val Gly Glu Glu Glu Glu Gly Gly Ala Val Ala Ser Ala Trp Phe 
    370                 375                 380                 


Ser Ala Arg Lys Arg Ala Met Leu Ala Pro Tyr Gly Val Gly Thr Leu 
385                 390                 395                 400 


Asp Gln Ala Leu Leu Gly Val Leu Arg Val Lys His His Phe Val Arg 
                405                 410                 415     


Leu Trp Gly Leu Met Asn Arg Val Val Val Leu Asp Glu Val His Ala 
            420                 425                 430         


Tyr Asp Val Tyr Thr Ser Gly Leu Leu Gln Ala Leu Leu Arg Trp Leu 
        435                 440                 445             


Arg Ala Leu Gly Ser Ser Ala Val Val Met Thr Ala Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Arg Arg Ala Leu Leu Glu Ala Trp Ala Gly Glu Glu Val Glu 
465                 470                 475                 480 


Gly Gln Asp Leu Gly Pro Tyr Pro Arg Val Val Leu Val Gly Glu Gly 
                485                 490                 495     


Val Lys Ala Arg Ser Leu Pro Pro Ala Arg Glu Val Glu Val Ala Leu 
            500                 505                 510         


Glu Val Leu Arg Glu Val Asp Val Glu Pro Leu Ala Gln Arg Leu Lys 
        515                 520                 525             


Gly Ala Leu Pro Gly Ala Val Gly Ala Ile Val Asn Thr Val Asp Arg 
    530                 535                 540                 


Ala Gln Asp Leu Tyr Arg Ala Leu Gly Glu Gly Thr Pro Leu Thr Leu 
545                 550                 555                 560 


Glu Glu Leu Ala Arg Arg Leu Gly Gly Ile Ser Gly Gly Gln Ala Trp 
                565                 570                 575     


Glu Glu Val Arg Gln Ala Leu Pro Glu Arg Gly Gly Glu Val Val Gly 
            580                 585                 590         


Lys Val Leu Thr Asp Gly Thr Leu Val Phe Leu Leu His Ala Arg Phe 
        595                 600                 605             


Pro Ala Glu Glu Arg Ala Leu Arg Gly Ser Val Val Leu Ala Leu Phe 
    610                 615                 620                 


Gly Lys Gly Gly Pro Arg Pro Pro Arg Ala Ile Leu Val Ala Thr Gln 
625                 630                 635                 640 


Val Ala Glu Gln Ser Leu Asp Leu Asp Phe Asp Leu Leu Tyr Thr Asp 
                645                 650                 655     


Leu Ala Pro Ile Asp Leu Leu Phe Gln Arg Ser Gly Arg Leu His Arg 
            660                 665                 670         


His Glu Arg Pro Arg Pro Glu Glu His Ala Arg Pro Arg Leu Leu Leu 
        675                 680                 685             


Gly Val Pro Glu Asp Leu Asp Phe Gly Lys Pro Leu Tyr Trp Asp Lys 
    690                 695                 700                 


Val Tyr Glu Asp Tyr Val Leu Leu Ala Thr Trp Arg Ala Leu Ser Gly 
705                 710                 715                 720 


Arg Asp Arg Leu Arg Val Pro Gly Asp Leu Glu Ala Leu Leu Glu Glu 
                725                 730                 735     


Ile Tyr Glu Gly Glu Asn Pro Glu Ser Phe Pro Glu Gly Leu Arg Glu 
            740                 745                 750         


Arg Ala Lys Lys Ser Leu Lys Ala Leu Gln Glu Arg Arg Asp Arg Glu 
        755                 760                 765             


Ala Asn Thr Ala Arg Arg Leu Ser Leu Ser Glu Leu Asp Arg Leu Leu 
    770                 775                 780                 


Ala Tyr Trp Asp Glu Gly Ala Leu Val Ala Gln Glu Arg Leu Glu Asp 
785                 790                 795                 800 


Asp Glu Glu Lys Ala Glu Thr Gln Arg Leu Leu Thr Arg Leu Gly Asp 
                805                 810                 815     


Pro Ser Val Ala Val Val Pro Leu Phe Arg Val Gly Glu Gly Leu Phe 
            820                 825                 830         


Leu Asp Arg Glu Gly Arg Arg Arg Ala Pro Leu Lys Gly Glu Val Ser 
        835                 840                 845             


Arg Glu Glu Ala Glu Ala Leu Phe Arg Arg Ala Val Arg Leu Ser Arg 
    850                 855                 860                 


Phe Pro Leu Pro Gln Glu Leu Leu Lys Glu Glu Pro Pro Pro Ala Trp 
865                 870                 875                 880 


Arg Lys Ser Gly Leu Leu Arg Gly Leu Arg Pro Leu Glu Val Gly Arg 
                885                 890                 895     


Val Phe Arg Ser Gly Glu Arg Ala Phe Gln Val Glu Leu Asp Pro Glu 
            900                 905                 910         


Leu Gly Val Val Tyr Leu Pro Val 
        915                 920 


<210>  1925
<211>  981
<212>  PRT
<213>  Streptomyces avermitilis

<400>  1925

Met Gly Ser Val Leu Val Ser Val Gln Val Arg Met Arg Cys Gln Trp 
1               5                   10                  15      


Gly Leu Leu Cys Met Ala Val Met Met Lys Arg Glu Ser Val Ser Pro 
            20                  25                  30          


Gly His Val Pro Val Asp Thr Arg Phe Trp Gly Lys Glu His Gly Leu 
        35                  40                  45              


Pro Arg Pro Tyr Pro Val Leu Cys His Leu Leu Asp Thr Ala Gly Val 
    50                  55                  60                  


Phe Gly Ala Leu Trp Asp Val Leu Leu Ser Asp Gln Met Arg Glu Lys 
65                  70                  75                  80  


Val Ala Arg Ala Leu Gly Leu Thr Val Ala Glu Ala Arg Arg Val Leu 
                85                  90                  95      


Ala Phe Trp Ala Gly Leu His Asp Leu Gly Lys Ile Thr Pro Pro Phe 
            100                 105                 110         


Gln Ala Gln Val Pro Glu Ala Phe Ala Ala Val Arg Asn Asp Pro Ala 
        115                 120                 125             


Tyr Val Phe Ala Pro Gly Ala Glu Arg Glu Arg Ala Phe Arg His Glu 
    130                 135                 140                 


Met Ala Thr His Trp Ala Leu Val Gln Leu Leu Gly Glu Ala Gly Tyr 
145                 150                 155                 160 


Pro Gly Gly Gly Arg Val Met Arg Ser Ala Val Ser His Gln Val Ala 
                165                 170                 175     


Gln Leu Leu Gly Gly His His Gly Cys Phe Gly Val Val Leu Lys Ala 
            180                 185                 190         


Lys Glu Val Ala His Ala Ser Ala Tyr Gln Pro Gly Leu Gly Gly Asp 
        195                 200                 205             


Gly Trp Ala Val Gln Arg Arg Ala His Phe Gly Glu Leu Arg Arg Val 
    210                 215                 220                 


Thr Gly Gly Trp Ala Val Pro Glu Arg Gly Leu Pro Ala Glu Leu Ala 
225                 230                 235                 240 


Val Ile Val Ala Gly Leu Val Val Val Ala Asp Trp Leu Ala Ser Gln 
                245                 250                 255     


Glu Glu Ala Ile Ile Pro Leu Leu Pro Pro Lys Gly Trp Arg Ala Thr 
            260                 265                 270         


Pro Glu Glu Val Asp Met His Trp Glu Arg Thr Gln Lys Ala Ala Pro 
        275                 280                 285             


Gly Leu Val Ala Gly Ala Gln Leu Gly Arg Ala Arg Phe Asp Ala Glu 
    290                 295                 300                 


Gly Phe Glu Glu Met Phe Ser Phe Ala Pro Asn Ala Leu Gln Ala Asp 
305                 310                 315                 320 


Leu Val Ala Arg Leu Pro Arg Met Val Glu Glu Lys Gly Pro Gly Leu 
                325                 330                 335     


Leu Leu Val Thr Ala Pro Thr Gly Asp Gly Lys Thr Glu Ala Ala Leu 
            340                 345                 350         


Tyr Ala Ala Ser Val Leu Gly His Ala Ala Gly Ala Arg Gly Leu Phe 
        355                 360                 365             


Phe Ala Leu Pro Thr Met Ala Thr Ala Asp Ala Met Tyr Pro Arg Val 
    370                 375                 380                 


Ser Ala Phe Thr Glu Arg Ala Leu Ser Gly Glu Arg Ala Leu Thr Leu 
385                 390                 395                 400 


Leu His Ser Met Ala Trp Leu Ser Pro Ala Tyr Ala Gly Ala Gly Gln 
                405                 410                 415     


Ser Ala Gly Pro Pro Pro Ala Ala Gly Asp Val Ser Ala Asp Pro Ala 
            420                 425                 430         


Thr Val Thr Glu Ala Gly Val Trp Leu Arg Gly His Arg Arg Gly Leu 
        435                 440                 445             


Leu Ala Pro Leu Gly Ala Gly Thr Ile Asp Gln Ala Leu Ser Ala Val 
    450                 455                 460                 


Leu Pro Leu Thr His Asn Ala Leu Arg Leu Phe Gly Leu Ser Asp Lys 
465                 470                 475                 480 


Val Leu Val Val Asp Glu Ala His Ala Tyr Gly Pro Trp Met His Gln 
                485                 490                 495     


Leu Leu Ser Arg Leu Leu Glu Trp Leu Gly Ala Phe Gly Ala Pro Val 
            500                 505                 510         


Val Leu Leu Ser Ala Thr Leu Ser Gly Arg Thr Ala Ser Ser Leu Val 
        515                 520                 525             


Asp Ala Tyr Arg Arg Gly Ala Gly Phe Leu Glu Pro Ser Ala Val Glu 
    530                 535                 540                 


Pro Cys Tyr Pro Gly Trp Met Phe Thr Gly Ala Ala Thr Gly Glu Val 
545                 550                 555                 560 


Cys Val Pro Arg Glu Thr Asp Ser Glu Arg Arg Arg Thr Leu Asp Val 
                565                 570                 575     


Arg Met Leu Pro Val Val Trp Asp Thr Ala Pro Ala Ala Gly Ser Pro 
            580                 585                 590         


Val Cys Ala Gly Gly Arg Arg Gln Ala Leu Arg Glu Ala Leu Glu Pro 
        595                 600                 605             


Val Val Ala Gln Ser Gly Thr Ala Leu Val Cys Cys Thr Thr Val Ala 
    610                 615                 620                 


Glu Ala Gln Gln Thr Phe Arg Asp Leu Arg Ala Ala Phe Pro Glu Leu 
625                 630                 635                 640 


Ser Thr Gly Glu Gly Gly Leu Arg Leu Leu His Ser Arg Tyr Pro Ala 
                645                 650                 655     


Asn Thr Arg Gln His Ile Thr Ser Ala Cys Glu Arg Ala Tyr Gly Lys 
            660                 665                 670         


Pro Arg Ser Pro Gln Asp Val Ala Leu Pro Arg Pro Ala Ser Val Leu 
        675                 680                 685             


Val Ala Thr Gln Val Val Glu Gln Ser Leu Asp Leu Asp Phe Asp Leu 
    690                 695                 700                 


Ile Val Thr Asp Leu Ala Pro Leu Ala Gln Leu Leu Gln Arg Ala Gly 
705                 710                 715                 720 


Arg Gly Arg Arg His Ala Arg Gly Ala Ser Gly Arg Pro Pro Trp Ala 
                725                 730                 735     


Leu Pro Glu Asp Ala Pro Arg Leu Val Val Leu Glu Pro Val Gly Glu 
            740                 745                 750         


Ser Gly Ala Thr Gln Val Pro Arg Thr Trp Gly Ser Val Tyr Asp Ala 
        755                 760                 765             


Gly Leu Leu Gln Arg Thr Ala His Leu Leu Arg Glu Arg Ala Ala Ser 
    770                 775                 780                 


Gly Ile Ala Val Pro Gly Asp Val Gln Glu Leu Ile Asp Ala Val Tyr 
785                 790                 795                 800 


Ala Glu Asp Phe Val Asp Arg Leu Glu Gly Ala Val Gln Arg Glu Leu 
                805                 810                 815     


Ala Arg Met Asp Ser Ala Arg Gln Ala Asp Glu Ala Ala Glu Ala His 
            820                 825                 830         


Leu Ala Asp Met Val Ala Ile Cys Ala Pro Ala Asp Val Ala Gly Asp 
        835                 840                 845             


Leu Gln Arg Leu Ser Arg Arg Glu Ala Gly Val Thr Glu Glu Leu Leu 
    850                 855                 860                 


Thr Thr Arg Leu Gly Ala Asp Ser Gly Arg Val Leu Cys Leu Tyr Glu 
865                 870                 875                 880 


Gln Gln Asp Asn Thr Leu Thr Leu Asp Glu Gly Gly Thr Leu Pro Leu 
                885                 890                 895     


Pro Thr Gly Asn Gln Asn Gly Leu Leu His Ala Glu Leu Arg Gln Val 
            900                 905                 910         


Met Ala His Met Ala Pro Val Pro Gly Ala Trp Leu Arg Gly Ala Glu 
        915                 920                 925             


Gly His Pro Ala Pro Pro Gly Trp Gly Lys His Pro Val Leu Arg Asp 
    930                 935                 940                 


Leu Val Leu Leu Arg Met Gln Pro Ala Gly Gln Asp Gly Ala Ala Ala 
945                 950                 955                 960 


Val Trp Ser Cys Arg His Gly Thr Arg Thr Ile Arg Ile Ser Gly Val 
                965                 970                 975     


Gly Leu Glu Thr Ser 
            980     


<210>  1926
<211>  11587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: single-chain FokI fusion to EcoCascade

<400>  1926
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

gagctcggat cgccaccatg cctaagaaga aaagaaaggt tggatcgggc atgtcaaatt      960

ttattaatat tcatgttctg atcagtcata gcccgagttg cctgaataga gacgacatga     1020

atatgcagaa agacgcaatt ttcggtggca agaggcgagt ccgaataagc agccaaagtc     1080

ttaagcgagc catgaggaag agcggctatt atgcccagaa tatcggcgag tcctcattgc     1140

ggaccatcca cctcgcccag ttgagagacg tcttgaggca gaaactgggg gaaagattcg     1200

accagaaaat cattgacaag acccttgccc tccttagtgg gaagagcgtg gacgaggctg     1260

aaaaaatctc tgccgacgcc gtaacgccct gggttgtggg tgagattgct tggttttgtg     1320

aacaggtggc gaaggcggag gccgataacc tggatgacaa gaagctgctg aaggtcctta     1380

aggaggacat agctgccatt cgggtcaatt tgcagcaggg agtggatatc gcattgtccg     1440

gaagaatggc tacatcaggc atgatgaccg agctgggcaa ggtagacgga gccatgagta     1500

tcgcacacgc catcaccacc caccaagtcg actcagacat cgactggttc acagcagtag     1560

atgacctcca ggagcagggg tctgcccacc ttgggacaca ggagttctct tccggggtgt     1620

tttatcgcta tgctaatatc aatctggcgc agctgcaaga aaacctgggg ggagcctctc     1680

gagagcaggc cctggagatt gcaactcacg tcgtgcatat gcttgcgaca gaggtacctg     1740

gcgccaagca gaggacatac gctgctttta atccagcaga tatggtcatg gtaaatttct     1800

ctgatatgcc tctctccatg gccaacgcat tcgagaaggc agtgaaggca aaggacgggt     1860

tcctgcagcc atcaattcaa gcgtttaatc agtattggga cagagtggcg aacggctatg     1920

gactgaacgg agccgcagct cagtttagcc tcagcgatgt cgatcccata actgcacagg     1980

tgaaacagat gcctacgttg gaacagctga agtcatgggt aagaaataac ggcgaagccg     2040

gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag aatcctggac     2100

ctccaaaaaa gaaaagaaag gtcggatcgg gcatggccga cgagattgac gcaatggcac     2160

tttaccgggc ctggcagcag ttggataatg gttcatgtgc ccagattcgc agagttagtg     2220

aacctgacga actgagagat atccccgcgt tttacagact tgtccaaccg ttcggatggg     2280

agaacccacg gcaccaacaa gcactccttc gaatggtctt ctgtttgtcc gcaggaaaaa     2340

atgtaatcag acaccaagac aaaaagagcg agcaaaccac aggtatcagc ctgggcaggg     2400

cacttgccaa ctctgggcgg atcaacgaaa ggagaatttt tcagctgata cgcgctgatc     2460

ggactgcgga catggtgcag ctgcgcagac tccttactca tgccgaacct gtcctggatt     2520

ggcccctgat ggcacgcatg ctgacttggt ggggaaagag agaaagacag caactgcttg     2580

aagacttcgt gctcactaca aataagaatg ccggatccgg agaaggaagg ggatccctcc     2640

tcacatgtgg agatgtcgaa gaaaatcctg gacctcccaa gaaaaagaga aaagtaggat     2700

cgggcatgcg gagctatctc atcctgagac tggccggacc aatgcaggcc tggggacagc     2760

ctaccttcga aggtacacgc cccacaggcc gctttcctac caggagcggc ctgctgggcc     2820

tgcttggcgc ttgtcttggg atccagcgcg atgatactag ctccctgcaa gcactgtcag     2880

agagcgtgca gtttgccgta agatgcgacg aactgatcct tgatgatagg cgggtcagtg     2940

tcactggtct ccgggactac cacacggtgc tgggggcccg ggaggattat aggggcctga     3000

aaagtcacga gacgattcaa acctggcgcg aatatctgtg cgatgccagc ttcaccgtgg     3060

ccctgtggct gactccacat gccactatgg tcatcagtga actggaaaag gctgttctta     3120

agcctcgata tactccgtat ctgggccgcc ggagttgtcc acttacacac ccacttttcc     3180

tcggcacctg ccaggccagc gaccctcaaa aggcccttct gaattacgag ccagttggcg     3240

gtgacatata cagcgaagag tccgtgacgg gacaccatct taagttcacc gctcgggacg     3300

agcccatgat taccctccca cggcagttcg catcaaggga gtggtacgtc ataaaggggg     3360

gcatggatgt gagtcagggg tctggggagg ggcgggggtc tttgttgact tgcggggatg     3420

ttgaggagaa tcctggacct cccaaaaaaa aacggaaggt gggctcaggc atgtatctgt     3480

caaaggttat cattgcacgc gcgtggagta gggatctgta tcagctgcac cagggtctgt     3540

ggcatctttt cccgaaccgc cccgacgcgg cacgagactt tctgtttcac gttgaaaaaa     3600

gaaacacccc cgagggctgt catgtgctcc tgcagtctgc ccagatgccg gtgagcacag     3660

ctgtggcgac tgtgatcaag accaagcagg tcgagtttca gctccaggta ggggttccac     3720

tgtattttcg cctgagagct aatccgatca aaaccatact ggataatcag aagaggctcg     3780

acagcaaagg aaatattaaa aggtgccggg tcccgctcat caaagaggct gagcaaatcg     3840

cttggcttca acggaaactg gggaacgcag cccgcgtgga agacgtccac ccgattagtg     3900

aacggcccca atatttttcc ggagacggaa agagcggcaa gattcagaca gtctgtttcg     3960

agggggtgct caccatcaat gatgcccccg ccctgataga cctggtgcag cagggcatag     4020

gccccgctaa aagcatggga tgcggactgc ttagtctggc accgctggga tccggagagg     4080

gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggacct cccaagaaaa     4140

agagaaaagt aggcggctca caattggtca aaagcgaact ggaagagaaa aaatctgagc     4200

tcagacacaa gctgaagtat gtgccccatg aatacataga actcatagaa atagctcgaa     4260

accccacgca ggaccggatc cttgaaatga aagttatgga gttttttatg aaagtgtatg     4320

ggtatcgagg agagcatctt ggtggaagtc ggaaaccgga tggggcaata tacactgttg     4380

ggagccccat tgactatggt gtgatagtgg acaccaaggc atacagcggg ggatacaatc     4440

tgccgatcgg gcaggcagat gagatgcagc gctatgtgga ggagaatcaa actaggaaca     4500

aacatattaa cccaaacgaa tggtggaaag tgtatccctc atctgttacg gagttcaagt     4560

tcctttttgt atctggccac tttaaaggaa actataaagc acagctcacg cgacttaacc     4620

acatcaccaa ttgtaacggt gctgtactca gtgttgagga actcctgatc ggtggtgaaa     4680

tgataaaagc tggaaccttg acattggagg aagtaaggag aaagtttaat aatggtgaga     4740

tcaatttcgg gggtggtgga tctggaggtg gcggatcggg aggtggcgga tcgggaggtg     4800

gcggatcggg aggtggcgga tcgggaggtg gcggatcggg aggtggcgga tcgggaggtg     4860

gcggatcggg aggtggcgga tcgggaggtg gcggatcggg aggtggcgga tcgggaggtg     4920

gcggatcggg aggtggcgga tcgggaggtg gcggatcggg cggcggcggc tcacaattgg     4980

tcaaaagcga actggaagag aaaaaatctg agctcagaca caagctgaag tatgtgcccc     5040

atgaatacat agaactcata gaaatagctc gaaaccccac gcaggaccgg atccttgaaa     5100

tgaaagttat ggagtttttt atgaaagtgt atgggtatcg aggagagcat cttggtggaa     5160

gtcggaaacc ggatggggca atatacactg ttgggagccc cattgactat ggtgtgatag     5220

tggacaccaa ggcatacagc gggggataca atctgccgat cgggcaggca gatgagatgc     5280

agcgctatgt ggaggagaat caaactagga acaaacatat taacccaaac gaatggtgga     5340

aagtgtatcc ctcatctgtt acggagttca agttcctttt tgtatctggc cactttaaag     5400

gaaactataa agcacagctc acgcgactta accacatcac caattgtaac ggtgctgtac     5460

tcagtgttga ggaactcctg atcggtggtg aaatgataaa agctggaacc ttgacattgg     5520

aggaagtaag gagaaagttt aataatggtg agatcaattt cgctgaccca actaacagag     5580

ctaagggcct ggaggccgta tctgtggcat caatgaattt gctcattgat aattggattc     5640

cggtgcgccc ccggaacggt gggaaagtgc agatcatcaa tttgcaaagt ctctactgtt     5700

ccagggacca gtggagactc agcctgccac gggatgatat ggagctggcg gcgttggctc     5760

tgctcgtatg catcggccag attattgcgc cagcaaagga tgacgttgaa ttccggcatc     5820

ggataatgaa cccccttact gaagatgagt tccagcagct tatcgcccca tggatcgaca     5880

tgttctacct caaccacgcc gagcatcctt ttatgcagac caagggagtc aaggcgaatg     5940

atgtgactcc catggagaag ctgctggccg gtgtatctgg ggcgaccaac tgcgcattcg     6000

tgaatcagcc tggacagggg gaggccctct gtggaggctg cactgctata gcacttttta     6060

accaagctaa tcaagccccc ggctttggtg gagggtttaa gagtggattg agggggggca     6120

ctcccgtaac cacttttgtg aggggaattg atctgaggtc tactgtgttg ctgaacgtcc     6180

tcacactccc aaggctccag aagcagttcc caaacgaaag tcataccgaa aaccagccca     6240

catggatcaa gcccatcaaa tctaatgaga gcataccggc tagcagtatt ggatttgtac     6300

ggggtctgtt ctggcagcca gctcacatcg agctgtgtga tcctattggg atcggcaagt     6360

gctcttgttg tgggcaggag tccaacctta ggtatactgg atttctgaaa gagaagttta     6420

cctttacagt aaatgggctc tggccccacc cccactcacc ttgccttgtg acagtgaaaa     6480

agggggaagt cgaggagaag tttctggcct ttacaacttc tgccccttcc tggactcaga     6540

tttccagagt ggtggtagat aagataattc aaaacgagaa tggcaataga gtggccgccg     6600

tggtgaacca gtttcgcaac atcgcccctc agtcccccct ggagctgatt atgggcggtt     6660

atcggaataa ccaggccagt atactcgagc gacggcacga tgtcctcatg ttcaatcaag     6720

gttggcagca atatggcaat gtgattaacg agatcgtaac cgtgggcctg ggatataaga     6780

ccgccctgcg gaaggcgttg tatacttttg cagaaggctt taagaataag gattttaagg     6840

gtgccggcgt gagtgtccat gaaacagctg aacggcactt ttatcggcag tccgagctgt     6900

tgataccaga cgtgctggct aatgtgaact tctcacaggc cgacgaagtg atcgctgatc     6960

tgcgggataa actgcaccaa ctgtgcgaga tgctgtttaa tcaaagcgtc gctccttatg     7020

cccaccaccc aaagctgatc tccacgctgg ccctggcgcg cgccacactt tataaacatc     7080

tccgcgaact gaaaccccag gggggcccca gcaatggcta ataatctaga gggccctatt     7140

ctatagtgtc acctaaatgc tagagctcgc tgatcagcct cgactgtgcc ttctagttgc     7200

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     7260

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     7320

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     7380

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct     7440

agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     7500

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     7560

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     7620

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     7680

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     7740

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     7800

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     7860

taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg tgtggaaagt     7920

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     7980

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     8040

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     8100

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     8160

cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     8220

gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag acaggatgag     8280

gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg     8340

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt     8400

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc     8460

tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt     8520

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag     8580

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg     8640

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag     8700

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg     8760

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc     8820

gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca     8880

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc     8940

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg     9000

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct     9060

atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga ccgaccaagc     9120

gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg aaaggttggg     9180

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct     9240

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa     9300

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     9360

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc     9420

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa     9480

catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac     9540

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca     9600

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc     9660

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     9720

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     9780

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     9840

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     9900

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     9960

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct    10020

ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg    10080

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct    10140

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat    10200

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg    10260

ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa    10320

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt    10380

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc    10440

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt    10500

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta    10560

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat    10620

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac    10680

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg    10740

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag    10800

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt    10860

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt    10920

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt    10980

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt    11040

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct    11100

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt    11160

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac    11220

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa    11280

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa    11340

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca    11400

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct    11460

ttttcattat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga    11520

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc    11580

tgacgtc                                                              11587


<210>  1927
<211>  2067
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: single-chain FokI fusion to EcoCascade

<400>  1927

Met Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Met Ser Asn Phe Ile 
1               5                   10                  15      


Asn Ile His Val Leu Ile Ser His Ser Pro Ser Cys Leu Asn Arg Asp 
            20                  25                  30          


Asp Met Asn Met Gln Lys Asp Ala Ile Phe Gly Gly Lys Arg Arg Val 
        35                  40                  45              


Arg Ile Ser Ser Gln Ser Leu Lys Arg Ala Met Arg Lys Ser Gly Tyr 
    50                  55                  60                  


Tyr Ala Gln Asn Ile Gly Glu Ser Ser Leu Arg Thr Ile His Leu Ala 
65                  70                  75                  80  


Gln Leu Arg Asp Val Leu Arg Gln Lys Leu Gly Glu Arg Phe Asp Gln 
                85                  90                  95      


Lys Ile Ile Asp Lys Thr Leu Ala Leu Leu Ser Gly Lys Ser Val Asp 
            100                 105                 110         


Glu Ala Glu Lys Ile Ser Ala Asp Ala Val Thr Pro Trp Val Val Gly 
        115                 120                 125             


Glu Ile Ala Trp Phe Cys Glu Gln Val Ala Lys Ala Glu Ala Asp Asn 
    130                 135                 140                 


Leu Asp Asp Lys Lys Leu Leu Lys Val Leu Lys Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Ile Arg Val Asn Leu Gln Gln Gly Val Asp Ile Ala Leu Ser Gly Arg 
                165                 170                 175     


Met Ala Thr Ser Gly Met Met Thr Glu Leu Gly Lys Val Asp Gly Ala 
            180                 185                 190         


Met Ser Ile Ala His Ala Ile Thr Thr His Gln Val Asp Ser Asp Ile 
        195                 200                 205             


Asp Trp Phe Thr Ala Val Asp Asp Leu Gln Glu Gln Gly Ser Ala His 
    210                 215                 220                 


Leu Gly Thr Gln Glu Phe Ser Ser Gly Val Phe Tyr Arg Tyr Ala Asn 
225                 230                 235                 240 


Ile Asn Leu Ala Gln Leu Gln Glu Asn Leu Gly Gly Ala Ser Arg Glu 
                245                 250                 255     


Gln Ala Leu Glu Ile Ala Thr His Val Val His Met Leu Ala Thr Glu 
            260                 265                 270         


Val Pro Gly Ala Lys Gln Arg Thr Tyr Ala Ala Phe Asn Pro Ala Asp 
        275                 280                 285             


Met Val Met Val Asn Phe Ser Asp Met Pro Leu Ser Met Ala Asn Ala 
    290                 295                 300                 


Phe Glu Lys Ala Val Lys Ala Lys Asp Gly Phe Leu Gln Pro Ser Ile 
305                 310                 315                 320 


Gln Ala Phe Asn Gln Tyr Trp Asp Arg Val Ala Asn Gly Tyr Gly Leu 
                325                 330                 335     


Asn Gly Ala Ala Ala Gln Phe Ser Leu Ser Asp Val Asp Pro Ile Thr 
            340                 345                 350         


Ala Gln Val Lys Gln Met Pro Thr Leu Glu Gln Leu Lys Ser Trp Val 
        355                 360                 365             


Arg Asn Asn Gly Glu Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
    370                 375                 380                 


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val Gly Ser Gly Met Ala Asp Glu Ile Asp Ala Met Ala Leu Tyr 
                405                 410                 415     


Arg Ala Trp Gln Gln Leu Asp Asn Gly Ser Cys Ala Gln Ile Arg Arg 
            420                 425                 430         


Val Ser Glu Pro Asp Glu Leu Arg Asp Ile Pro Ala Phe Tyr Arg Leu 
        435                 440                 445             


Val Gln Pro Phe Gly Trp Glu Asn Pro Arg His Gln Gln Ala Leu Leu 
    450                 455                 460                 


Arg Met Val Phe Cys Leu Ser Ala Gly Lys Asn Val Ile Arg His Gln 
465                 470                 475                 480 


Asp Lys Lys Ser Glu Gln Thr Thr Gly Ile Ser Leu Gly Arg Ala Leu 
                485                 490                 495     


Ala Asn Ser Gly Arg Ile Asn Glu Arg Arg Ile Phe Gln Leu Ile Arg 
            500                 505                 510         


Ala Asp Arg Thr Ala Asp Met Val Gln Leu Arg Arg Leu Leu Thr His 
        515                 520                 525             


Ala Glu Pro Val Leu Asp Trp Pro Leu Met Ala Arg Met Leu Thr Trp 
    530                 535                 540                 


Trp Gly Lys Arg Glu Arg Gln Gln Leu Leu Glu Asp Phe Val Leu Thr 
545                 550                 555                 560 


Thr Asn Lys Asn Ala Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                565                 570                 575     


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys 
            580                 585                 590         


Val Gly Ser Gly Met Arg Ser Tyr Leu Ile Leu Arg Leu Ala Gly Pro 
        595                 600                 605             


Met Gln Ala Trp Gly Gln Pro Thr Phe Glu Gly Thr Arg Pro Thr Gly 
    610                 615                 620                 


Arg Phe Pro Thr Arg Ser Gly Leu Leu Gly Leu Leu Gly Ala Cys Leu 
625                 630                 635                 640 


Gly Ile Gln Arg Asp Asp Thr Ser Ser Leu Gln Ala Leu Ser Glu Ser 
                645                 650                 655     


Val Gln Phe Ala Val Arg Cys Asp Glu Leu Ile Leu Asp Asp Arg Arg 
            660                 665                 670         


Val Ser Val Thr Gly Leu Arg Asp Tyr His Thr Val Leu Gly Ala Arg 
        675                 680                 685             


Glu Asp Tyr Arg Gly Leu Lys Ser His Glu Thr Ile Gln Thr Trp Arg 
    690                 695                 700                 


Glu Tyr Leu Cys Asp Ala Ser Phe Thr Val Ala Leu Trp Leu Thr Pro 
705                 710                 715                 720 


His Ala Thr Met Val Ile Ser Glu Leu Glu Lys Ala Val Leu Lys Pro 
                725                 730                 735     


Arg Tyr Thr Pro Tyr Leu Gly Arg Arg Ser Cys Pro Leu Thr His Pro 
            740                 745                 750         


Leu Phe Leu Gly Thr Cys Gln Ala Ser Asp Pro Gln Lys Ala Leu Leu 
        755                 760                 765             


Asn Tyr Glu Pro Val Gly Gly Asp Ile Tyr Ser Glu Glu Ser Val Thr 
    770                 775                 780                 


Gly His His Leu Lys Phe Thr Ala Arg Asp Glu Pro Met Ile Thr Leu 
785                 790                 795                 800 


Pro Arg Gln Phe Ala Ser Arg Glu Trp Tyr Val Ile Lys Gly Gly Met 
                805                 810                 815     


Asp Val Ser Gln Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            820                 825                 830         


Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
        835                 840                 845             


Gly Ser Gly Met Tyr Leu Ser Lys Val Ile Ile Ala Arg Ala Trp Ser 
    850                 855                 860                 


Arg Asp Leu Tyr Gln Leu His Gln Gly Leu Trp His Leu Phe Pro Asn 
865                 870                 875                 880 


Arg Pro Asp Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn 
                885                 890                 895     


Thr Pro Glu Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val 
            900                 905                 910         


Ser Thr Ala Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln 
        915                 920                 925             


Leu Gln Val Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile 
    930                 935                 940                 


Lys Thr Ile Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile 
945                 950                 955                 960 


Lys Arg Cys Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp 
                965                 970                 975     


Leu Gln Arg Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro 
            980                 985                 990         


Ile Ser Glu Arg Pro Gln Tyr Phe  Ser Gly Asp Gly Lys  Ser Gly Lys 
        995                 1000                 1005             


Ile Gln  Thr Val Cys Phe Glu  Gly Val Leu Thr Ile  Asn Asp Ala 
    1010                 1015                 1020             


Pro Ala  Leu Ile Asp Leu Val  Gln Gln Gly Ile Gly  Pro Ala Lys 
    1025                 1030                 1035             


Ser Met  Gly Cys Gly Leu Leu  Ser Leu Ala Pro Leu  Gly Ser Gly 
    1040                 1045                 1050             


Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly Asp Val  Glu Glu Asn 
    1055                 1060                 1065             


Pro Gly  Pro Pro Lys Lys Lys  Arg Lys Val Gly Gly  Ser Gln Leu 
    1070                 1075                 1080             


Val Lys  Ser Glu Leu Glu Glu  Lys Lys Ser Glu Leu  Arg His Lys 
    1085                 1090                 1095             


Leu Lys  Tyr Val Pro His Glu  Tyr Ile Glu Leu Ile  Glu Ile Ala 
    1100                 1105                 1110             


Arg Asn  Pro Thr Gln Asp Arg  Ile Leu Glu Met Lys  Val Met Glu 
    1115                 1120                 1125             


Phe Phe  Met Lys Val Tyr Gly  Tyr Arg Gly Glu His  Leu Gly Gly 
    1130                 1135                 1140             


Ser Arg  Lys Pro Asp Gly Ala  Ile Tyr Thr Val Gly  Ser Pro Ile 
    1145                 1150                 1155             


Asp Tyr  Gly Val Ile Val Asp  Thr Lys Ala Tyr Ser  Gly Gly Tyr 
    1160                 1165                 1170             


Asn Leu  Pro Ile Gly Gln Ala  Asp Glu Met Gln Arg  Tyr Val Glu 
    1175                 1180                 1185             


Glu Asn  Gln Thr Arg Asn Lys  His Ile Asn Pro Asn  Glu Trp Trp 
    1190                 1195                 1200             


Lys Val  Tyr Pro Ser Ser Val  Thr Glu Phe Lys Phe  Leu Phe Val 
    1205                 1210                 1215             


Ser Gly  His Phe Lys Gly Asn  Tyr Lys Ala Gln Leu  Thr Arg Leu 
    1220                 1225                 1230             


Asn His  Ile Thr Asn Cys Asn  Gly Ala Val Leu Ser  Val Glu Glu 
    1235                 1240                 1245             


Leu Leu  Ile Gly Gly Glu Met  Ile Lys Ala Gly Thr  Leu Thr Leu 
    1250                 1255                 1260             


Glu Glu  Val Arg Arg Lys Phe  Asn Asn Gly Glu Ile  Asn Phe Gly 
    1265                 1270                 1275             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1280                 1285                 1290             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1295                 1300                 1305             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1310                 1315                 1320             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1325                 1330                 1335             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gln 
    1340                 1345                 1350             


Leu Val  Lys Ser Glu Leu Glu  Glu Lys Lys Ser Glu  Leu Arg His 
    1355                 1360                 1365             


Lys Leu  Lys Tyr Val Pro His  Glu Tyr Ile Glu Leu  Ile Glu Ile 
    1370                 1375                 1380             


Ala Arg  Asn Pro Thr Gln Asp  Arg Ile Leu Glu Met  Lys Val Met 
    1385                 1390                 1395             


Glu Phe  Phe Met Lys Val Tyr  Gly Tyr Arg Gly Glu  His Leu Gly 
    1400                 1405                 1410             


Gly Ser  Arg Lys Pro Asp Gly  Ala Ile Tyr Thr Val  Gly Ser Pro 
    1415                 1420                 1425             


Ile Asp  Tyr Gly Val Ile Val  Asp Thr Lys Ala Tyr  Ser Gly Gly 
    1430                 1435                 1440             


Tyr Asn  Leu Pro Ile Gly Gln  Ala Asp Glu Met Gln  Arg Tyr Val 
    1445                 1450                 1455             


Glu Glu  Asn Gln Thr Arg Asn  Lys His Ile Asn Pro  Asn Glu Trp 
    1460                 1465                 1470             


Trp Lys  Val Tyr Pro Ser Ser  Val Thr Glu Phe Lys  Phe Leu Phe 
    1475                 1480                 1485             


Val Ser  Gly His Phe Lys Gly  Asn Tyr Lys Ala Gln  Leu Thr Arg 
    1490                 1495                 1500             


Leu Asn  His Ile Thr Asn Cys  Asn Gly Ala Val Leu  Ser Val Glu 
    1505                 1510                 1515             


Glu Leu  Leu Ile Gly Gly Glu  Met Ile Lys Ala Gly  Thr Leu Thr 
    1520                 1525                 1530             


Leu Glu  Glu Val Arg Arg Lys  Phe Asn Asn Gly Glu  Ile Asn Phe 
    1535                 1540                 1545             


Ala Asp  Pro Thr Asn Arg Ala  Lys Gly Leu Glu Ala  Val Ser Val 
    1550                 1555                 1560             


Ala Ser  Met Asn Leu Leu Ile  Asp Asn Trp Ile Pro  Val Arg Pro 
    1565                 1570                 1575             


Arg Asn  Gly Gly Lys Val Gln  Ile Ile Asn Leu Gln  Ser Leu Tyr 
    1580                 1585                 1590             


Cys Ser  Arg Asp Gln Trp Arg  Leu Ser Leu Pro Arg  Asp Asp Met 
    1595                 1600                 1605             


Glu Leu  Ala Ala Leu Ala Leu  Leu Val Cys Ile Gly  Gln Ile Ile 
    1610                 1615                 1620             


Ala Pro  Ala Lys Asp Asp Val  Glu Phe Arg His Arg  Ile Met Asn 
    1625                 1630                 1635             


Pro Leu  Thr Glu Asp Glu Phe  Gln Gln Leu Ile Ala  Pro Trp Ile 
    1640                 1645                 1650             


Asp Met  Phe Tyr Leu Asn His  Ala Glu His Pro Phe  Met Gln Thr 
    1655                 1660                 1665             


Lys Gly  Val Lys Ala Asn Asp  Val Thr Pro Met Glu  Lys Leu Leu 
    1670                 1675                 1680             


Ala Gly  Val Ser Gly Ala Thr  Asn Cys Ala Phe Val  Asn Gln Pro 
    1685                 1690                 1695             


Gly Gln  Gly Glu Ala Leu Cys  Gly Gly Cys Thr Ala  Ile Ala Leu 
    1700                 1705                 1710             


Phe Asn  Gln Ala Asn Gln Ala  Pro Gly Phe Gly Gly  Gly Phe Lys 
    1715                 1720                 1725             


Ser Gly  Leu Arg Gly Gly Thr  Pro Val Thr Thr Phe  Val Arg Gly 
    1730                 1735                 1740             


Ile Asp  Leu Arg Ser Thr Val  Leu Leu Asn Val Leu  Thr Leu Pro 
    1745                 1750                 1755             


Arg Leu  Gln Lys Gln Phe Pro  Asn Glu Ser His Thr  Glu Asn Gln 
    1760                 1765                 1770             


Pro Thr  Trp Ile Lys Pro Ile  Lys Ser Asn Glu Ser  Ile Pro Ala 
    1775                 1780                 1785             


Ser Ser  Ile Gly Phe Val Arg  Gly Leu Phe Trp Gln  Pro Ala His 
    1790                 1795                 1800             


Ile Glu  Leu Cys Asp Pro Ile  Gly Ile Gly Lys Cys  Ser Cys Cys 
    1805                 1810                 1815             


Gly Gln  Glu Ser Asn Leu Arg  Tyr Thr Gly Phe Leu  Lys Glu Lys 
    1820                 1825                 1830             


Phe Thr  Phe Thr Val Asn Gly  Leu Trp Pro His Pro  His Ser Pro 
    1835                 1840                 1845             


Cys Leu  Val Thr Val Lys Lys  Gly Glu Val Glu Glu  Lys Phe Leu 
    1850                 1855                 1860             


Ala Phe  Thr Thr Ser Ala Pro  Ser Trp Thr Gln Ile  Ser Arg Val 
    1865                 1870                 1875             


Val Val  Asp Lys Ile Ile Gln  Asn Glu Asn Gly Asn  Arg Val Ala 
    1880                 1885                 1890             


Ala Val  Val Asn Gln Phe Arg  Asn Ile Ala Pro Gln  Ser Pro Leu 
    1895                 1900                 1905             


Glu Leu  Ile Met Gly Gly Tyr  Arg Asn Asn Gln Ala  Ser Ile Leu 
    1910                 1915                 1920             


Glu Arg  Arg His Asp Val Leu  Met Phe Asn Gln Gly  Trp Gln Gln 
    1925                 1930                 1935             


Tyr Gly  Asn Val Ile Asn Glu  Ile Val Thr Val Gly  Leu Gly Tyr 
    1940                 1945                 1950             


Lys Thr  Ala Leu Arg Lys Ala  Leu Tyr Thr Phe Ala  Glu Gly Phe 
    1955                 1960                 1965             


Lys Asn  Lys Asp Phe Lys Gly  Ala Gly Val Ser Val  His Glu Thr 
    1970                 1975                 1980             


Ala Glu  Arg His Phe Tyr Arg  Gln Ser Glu Leu Leu  Ile Pro Asp 
    1985                 1990                 1995             


Val Leu  Ala Asn Val Asn Phe  Ser Gln Ala Asp Glu  Val Ile Ala 
    2000                 2005                 2010             


Asp Leu  Arg Asp Lys Leu His  Gln Leu Cys Glu Met  Leu Phe Asn 
    2015                 2020                 2025             


Gln Ser  Val Ala Pro Tyr Ala  His His Pro Lys Leu  Ile Ser Thr 
    2030                 2035                 2040             


Leu Ala  Leu Ala Arg Ala Thr  Leu Tyr Lys His Leu  Arg Glu Leu 
    2045                 2050                 2055             


Lys Pro  Gln Gly Gly Pro Ser  Asn Gly 
    2060                 2065         


