                         SEQUENCE LISTING

<110>  Manus Bio, Inc.
       PHILIPPE, Ryan
       Parayil KUMARON, Ajikumar
       Nicole SANTOS, Christine
 
<120>  ENZYMES, METHODS, AND HOST CELLS FOR PRODUCING CARMINIC ACID

<130>  MAN-017PC/107590-5017

<150>  62/684,440
<151>  2018-06-13

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1548
<212>  DNA
<213>  Dactylopius coccus

<400>  1
atggaatttc gtttactaat cctggctctt ttttctgtac ttatgagtac ttcaaacgga       60

gcagaaattt tagctctttt ccctattcac ggtatcagta attataatgt tgctgaagca      120

ctgctgaaga ccttagctaa ccggggtcat aatgttacag ttgtcacatc ttttcctcaa      180

aaaaaacctg tacctaattt gtacgaaatt gacgtatctg gagctaaagg cttggctact      240

aattcaatac attttgaaag attacaaacg attattcaag atgtaaaatc gaactttaag      300

aacatggtac gacttagcag aacatactgt gagattatgt tttctgatcc gagggttttg      360

aacattcgag acaagaaatt cgatctcgta ataaacgccg tatttggcag tgactgcgat      420

gccggattcg catggaaaag tcaagctcca ttgatttcaa ttctcaatgc tagacatact      480

ccttgggccc tacacagaat gggaaatcca tcaaatccag cgtatatgcc tgtcattcat      540

tctagatttc ctgtaaaaat gaatttcttc caaagaatga taaatacggg ttggcatttg      600

tattttctgt acatgtactt ttattatggt aatggagaag atgccaacaa aatggcgaga      660

aaattttttg gcaacgacat gcccgacata aatgaaatgg tttttaatac atctttatta      720

ttcgtaaata ctcacttttc ggttgatatg ccatatcctt tggttccaaa ctgcattgaa      780

ataggaggaa tacatgtaaa agagccacaa ccactgcctt tggaaataca aaaattcatg      840

gacgaagcag aacatggggt cattttcttc acgctaggat caatggtgcg tacttccacg      900

tttccaaatc aaactattca agcatttaag gaagcttttg ccgaattacc tcaaagagtc      960

ttatggaagt ttgagaatga aaatgaggat atgccatcaa atgtactcat aaggaaatgg     1020

tttccacaaa atgatatatt cggtcataag aatatcaaag cattcattag tcacggtgga     1080

aattctggag ctctggaggc tgttcatttc ggagtaccga taattggaat tcctttattc     1140

tacgatcagt acaggaatat tttgagtttc gttaaagaag gtgttgccgt tcttttggat     1200

gtgaatgatc tgacgaaaga taatatttta tcttctgtca ggactgttgt taatgataag     1260

agttactcag aacgtatgaa agcattgtca caactattcc gagatcgacc aatgagtcct     1320

cttgacacag ctgtttactg gacagaatat gtcatccgcc atagaggagc ccatcacctc     1380

aagaccgctg gcgcattttt gcattggtat cagtatttac ttttggacgt tattaccttc     1440

ttattagtca cattctgcgc tttttgtttt attgtgaaat atatatgtaa agctctcatt     1500

catcattatt ggagcagttc gaaatctgaa aagttgaaaa aaaattaa                  1548


<210>  2
<211>  515
<212>  PRT
<213>  Dactylopius coccus

<400>  2

Met Glu Phe Arg Leu Leu Ile Leu Ala Leu Phe Ser Val Leu Met Ser 
1               5                   10                  15      


Thr Ser Asn Gly Ala Glu Ile Leu Ala Leu Phe Pro Ile His Gly Ile 
            20                  25                  30          


Ser Asn Tyr Asn Val Ala Glu Ala Leu Leu Lys Thr Leu Ala Asn Arg 
        35                  40                  45              


Gly His Asn Val Thr Val Val Thr Ser Phe Pro Gln Lys Lys Pro Val 
    50                  55                  60                  


Pro Asn Leu Tyr Glu Ile Asp Val Ser Gly Ala Lys Gly Leu Ala Thr 
65                  70                  75                  80  


Asn Ser Ile His Phe Glu Arg Leu Gln Thr Ile Ile Gln Asp Val Lys 
                85                  90                  95      


Ser Asn Phe Lys Asn Met Val Arg Leu Ser Arg Thr Tyr Cys Glu Ile 
            100                 105                 110         


Met Phe Ser Asp Pro Arg Val Leu Asn Ile Arg Asp Lys Lys Phe Asp 
        115                 120                 125             


Leu Val Ile Asn Ala Val Phe Gly Ser Asp Cys Asp Ala Gly Phe Ala 
    130                 135                 140                 


Trp Lys Ser Gln Ala Pro Leu Ile Ser Ile Leu Asn Ala Arg His Thr 
145                 150                 155                 160 


Pro Trp Ala Leu His Arg Met Gly Asn Pro Ser Asn Pro Ala Tyr Met 
                165                 170                 175     


Pro Val Ile His Ser Arg Phe Pro Val Lys Met Asn Phe Phe Gln Arg 
            180                 185                 190         


Met Ile Asn Thr Gly Trp His Leu Tyr Phe Leu Tyr Met Tyr Phe Tyr 
        195                 200                 205             


Tyr Gly Asn Gly Glu Asp Ala Asn Lys Met Ala Arg Lys Phe Phe Gly 
    210                 215                 220                 


Asn Asp Met Pro Asp Ile Asn Glu Met Val Phe Asn Thr Ser Leu Leu 
225                 230                 235                 240 


Phe Val Asn Thr His Phe Ser Val Asp Met Pro Tyr Pro Leu Val Pro 
                245                 250                 255     


Asn Cys Ile Glu Ile Gly Gly Ile His Val Lys Glu Pro Gln Pro Leu 
            260                 265                 270         


Pro Leu Glu Ile Gln Lys Phe Met Asp Glu Ala Glu His Gly Val Ile 
        275                 280                 285             


Phe Phe Thr Leu Gly Ser Met Val Arg Thr Ser Thr Phe Pro Asn Gln 
    290                 295                 300                 


Thr Ile Gln Ala Phe Lys Glu Ala Phe Ala Glu Leu Pro Gln Arg Val 
305                 310                 315                 320 


Leu Trp Lys Phe Glu Asn Glu Asn Glu Asp Met Pro Ser Asn Val Leu 
                325                 330                 335     


Ile Arg Lys Trp Phe Pro Gln Asn Asp Ile Phe Gly His Lys Asn Ile 
            340                 345                 350         


Lys Ala Phe Ile Ser His Gly Gly Asn Ser Gly Ala Leu Glu Ala Val 
        355                 360                 365             


His Phe Gly Val Pro Ile Ile Gly Ile Pro Leu Phe Tyr Asp Gln Tyr 
    370                 375                 380                 


Arg Asn Ile Leu Ser Phe Val Lys Glu Gly Val Ala Val Leu Leu Asp 
385                 390                 395                 400 


Val Asn Asp Leu Thr Lys Asp Asn Ile Leu Ser Ser Val Arg Thr Val 
                405                 410                 415     


Val Asn Asp Lys Ser Tyr Ser Glu Arg Met Lys Ala Leu Ser Gln Leu 
            420                 425                 430         


Phe Arg Asp Arg Pro Met Ser Pro Leu Asp Thr Ala Val Tyr Trp Thr 
        435                 440                 445             


Glu Tyr Val Ile Arg His Arg Gly Ala His His Leu Lys Thr Ala Gly 
    450                 455                 460                 


Ala Phe Leu His Trp Tyr Gln Tyr Leu Leu Leu Asp Val Ile Thr Phe 
465                 470                 475                 480 


Leu Leu Val Thr Phe Cys Ala Phe Cys Phe Ile Val Lys Tyr Ile Cys 
                485                 490                 495     


Lys Ala Leu Ile His His Tyr Trp Ser Ser Ser Lys Ser Glu Lys Leu 
            500                 505                 510         


Lys Lys Asn 
        515 


<210>  3
<211>  467
<212>  PRT
<213>  Streptomyces coelicolor

<400>  3

Met Pro Leu Asp Ala Ala Pro Val Asp Pro Ala Ser Arg Gly Pro Val 
1               5                   10                  15      


Ser Ala Phe Glu Pro Pro Ser Ser His Gly Ala Asp Asp Asp Asp Asp 
            20                  25                  30          


His Arg Thr Asn Ala Ser Lys Glu Leu Phe Gly Leu Lys Arg Arg Val 
        35                  40                  45              


Val Ile Thr Gly Val Gly Val Arg Ala Pro Gly Gly Asn Gly Thr Arg 
    50                  55                  60                  


Gln Phe Trp Glu Leu Leu Thr Ser Gly Arg Thr Ala Thr Arg Arg Ile 
65                  70                  75                  80  


Ser Phe Phe Asp Pro Ser Pro Tyr Arg Ser Gln Val Ala Ala Glu Ala 
                85                  90                  95      


Asp Phe Asp Pro Val Ala Glu Gly Phe Gly Pro Arg Glu Leu Asp Arg 
            100                 105                 110         


Met Asp Arg Ala Ser Gln Phe Ala Val Ala Cys Ala Arg Glu Ala Phe 
        115                 120                 125             


Ala Ala Ser Gly Leu Asp Pro Asp Thr Leu Asp Pro Ala Arg Val Gly 
    130                 135                 140                 


Val Ser Leu Gly Ser Ala Val Ala Ala Ala Thr Ser Leu Glu Arg Glu 
145                 150                 155                 160 


Tyr Leu Leu Leu Ser Asp Ser Gly Arg Asp Trp Glu Val Asp Ala Ala 
                165                 170                 175     


Trp Leu Ser Arg His Met Phe Asp Tyr Leu Val Pro Ser Val Met Pro 
            180                 185                 190         


Ala Glu Val Ala Trp Ala Val Gly Ala Glu Gly Pro Val Thr Met Val 
        195                 200                 205             


Ser Thr Gly Cys Thr Ser Gly Leu Asp Ser Val Gly Asn Ala Val Arg 
    210                 215                 220                 


Ala Ile Glu Glu Gly Ser Ala Asp Val Met Phe Ala Gly Ala Ala Asp 
225                 230                 235                 240 


Thr Pro Ile Thr Pro Ile Val Val Ala Cys Phe Asp Ala Ile Arg Ala 
                245                 250                 255     


Thr Thr Ala Arg Asn Asp Asp Pro Glu His Ala Ser Arg Pro Phe Asp 
            260                 265                 270         


Gly Thr Arg Asp Gly Phe Val Leu Ala Glu Gly Ala Ala Met Phe Val 
        275                 280                 285             


Leu Glu Asp Tyr Asp Ser Ala Leu Ala Arg Gly Ala Arg Ile His Ala 
    290                 295                 300                 


Glu Ile Ser Gly Tyr Ala Thr Arg Cys Asn Ala Tyr His Met Thr Gly 
305                 310                 315                 320 


Leu Lys Ala Asp Gly Arg Glu Met Ala Glu Thr Ile Arg Val Ala Leu 
                325                 330                 335     


Asp Glu Ser Arg Thr Asp Ala Thr Asp Ile Asp Tyr Ile Asn Ala His 
            340                 345                 350         


Gly Ser Gly Thr Arg Gln Asn Asp Arg His Glu Thr Ala Ala Tyr Lys 
        355                 360                 365             


Arg Ala Leu Gly Glu His Ala Arg Arg Thr Pro Val Ser Ser Ile Lys 
    370                 375                 380                 


Ser Met Val Gly His Ser Leu Gly Ala Ile Gly Ser Leu Glu Ile Ala 
385                 390                 395                 400 


Ala Cys Val Leu Ala Leu Glu His Gly Val Val Pro Pro Thr Ala Asn 
                405                 410                 415     


Leu Arg Thr Ser Asp Pro Glu Cys Asp Leu Asp Tyr Val Pro Leu Glu 
            420                 425                 430         


Ala Arg Glu Arg Lys Leu Arg Ser Val Leu Thr Val Gly Ser Gly Phe 
        435                 440                 445             


Gly Gly Phe Gln Ser Ala Met Val Leu Arg Asp Ala Glu Thr Ala Gly 
    450                 455                 460                 


Ala Ala Ala 
465         


<210>  4
<211>  407
<212>  PRT
<213>  Streptomyces coelicolor

<400>  4

Met Ser Val Leu Ile Thr Gly Val Gly Val Val Ala Pro Asn Gly Leu 
1               5                   10                  15      


Gly Leu Ala Pro Tyr Trp Ser Ala Val Leu Asp Gly Arg His Gly Leu 
            20                  25                  30          


Gly Pro Val Thr Arg Phe Asp Val Ser Arg Tyr Pro Ala Thr Leu Ala 
        35                  40                  45              


Gly Gln Ile Asp Asp Phe His Ala Pro Asp His Ile Pro Gly Arg Leu 
    50                  55                  60                  


Leu Pro Gln Thr Asp Pro Ser Thr Arg Leu Ala Leu Thr Ala Ala Asp 
65                  70                  75                  80  


Trp Ala Leu Gln Asp Ala Lys Ala Asp Pro Glu Ser Leu Thr Asp Tyr 
                85                  90                  95      


Asp Met Gly Val Val Thr Ala Asn Ala Cys Gly Gly Phe Asp Phe Thr 
            100                 105                 110         


His Arg Glu Phe Arg Lys Leu Trp Ser Glu Gly Pro Lys Ser Val Ser 
        115                 120                 125             


Val Tyr Glu Ser Phe Ala Trp Phe Tyr Ala Val Asn Thr Gly Gln Ile 
    130                 135                 140                 


Ser Ile Arg His Gly Met Arg Gly Pro Ser Ser Ala Leu Val Ala Glu 
145                 150                 155                 160 


Gln Ala Gly Gly Leu Asp Ala Leu Gly His Ala Arg Arg Thr Ile Arg 
                165                 170                 175     


Arg Gly Thr Pro Leu Val Val Ser Gly Gly Val Asp Ser Ala Leu Asp 
            180                 185                 190         


Pro Trp Gly Trp Val Ser Gln Ile Ala Ser Gly Arg Ile Ser Thr Ala 
        195                 200                 205             


Thr Asp Pro Asp Arg Ala Tyr Leu Pro Phe Asp Glu Arg Ala Ala Gly 
    210                 215                 220                 


Tyr Val Pro Gly Glu Gly Gly Ala Ile Leu Val Leu Glu Asp Ser Ala 
225                 230                 235                 240 


Ala Ala Glu Ala Arg Gly Arg His Asp Ala Tyr Gly Glu Leu Ala Gly 
                245                 250                 255     


Cys Ala Ser Thr Phe Asp Pro Ala Pro Gly Ser Gly Arg Pro Ala Gly 
            260                 265                 270         


Leu Glu Arg Ala Ile Arg Leu Ala Leu Asn Asp Ala Gly Thr Gly Pro 
        275                 280                 285             


Glu Asp Val Asp Val Val Phe Ala Asp Gly Ala Gly Val Pro Glu Leu 
    290                 295                 300                 


Asp Ala Ala Glu Ala Arg Ala Ile Gly Arg Val Phe Gly Arg Glu Gly 
305                 310                 315                 320 


Val Pro Val Thr Val Pro Lys Thr Thr Thr Gly Arg Leu Tyr Ser Gly 
                325                 330                 335     


Gly Gly Pro Leu Asp Val Val Thr Ala Leu Met Ser Leu Arg Glu Gly 
            340                 345                 350         


Val Ile Ala Pro Thr Ala Gly Val Thr Ser Val Pro Arg Glu Tyr Gly 
        355                 360                 365             


Ile Asp Leu Val Leu Gly Glu Pro Arg Ser Thr Ala Pro Arg Thr Ala 
    370                 375                 380                 


Leu Val Leu Ala Arg Gly Arg Trp Gly Phe Asn Ser Ala Ala Val Leu 
385                 390                 395                 400 


Arg Arg Phe Ala Pro Thr Pro 
                405         


<210>  5
<211>  82
<212>  PRT
<213>  Streptomyces

<400>  5

Met Thr Ile Asp Asp Leu Arg Arg Ile Leu Thr Glu Cys Ala Gly Glu 
1               5                   10                  15      


Asp Glu Ser Val Asp Leu Gly Gly Asp Ile Leu Asp Thr Pro Phe Thr 
            20                  25                  30          


Glu Leu Gly Tyr Asp Ser Leu Ala Leu Met Glu Thr Ala Ala Arg Ile 
        35                  40                  45              


Glu Gln Glu Phe Gly Val Ala Ile Pro Asp Asp Glu Phe Ala Glu Leu 
    50                  55                  60                  


Ala Thr Pro Arg Ala Val Leu Ala Ala Val Ser Thr Ala Val Ser Ala 
65                  70                  75                  80  


Ala Ala 
        


<210>  6
<211>  2051
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Asp Ala Tyr Ser Thr Arg Pro Leu Thr Leu Ser His Gly Ser Leu 
1               5                   10                  15      


Glu His Val Leu Leu Val Pro Thr Ala Ser Phe Phe Ile Ala Ser Gln 
            20                  25                  30          


Leu Gln Glu Gln Phe Asn Lys Ile Leu Pro Glu Pro Thr Glu Gly Phe 
        35                  40                  45              


Ala Ala Asp Asp Glu Pro Thr Thr Pro Ala Glu Leu Val Gly Lys Phe 
    50                  55                  60                  


Leu Gly Tyr Val Ser Ser Leu Val Glu Pro Ser Lys Val Gly Gln Phe 
65                  70                  75                  80  


Asp Gln Val Leu Asn Leu Cys Leu Thr Glu Phe Glu Asn Cys Tyr Leu 
                85                  90                  95      


Glu Gly Asn Asp Ile His Ala Leu Ala Ala Lys Leu Leu Gln Glu Asn 
            100                 105                 110         


Asp Thr Thr Leu Val Lys Thr Lys Glu Leu Ile Lys Asn Tyr Ile Thr 
        115                 120                 125             


Ala Arg Ile Met Ala Lys Arg Pro Phe Asp Lys Lys Ser Asn Ser Ala 
    130                 135                 140                 


Leu Phe Arg Ala Val Gly Glu Gly Asn Ala Gln Leu Val Ala Ile Phe 
145                 150                 155                 160 


Gly Gly Gln Gly Asn Thr Asp Asp Tyr Phe Glu Glu Leu Arg Asp Leu 
                165                 170                 175     


Tyr Gln Thr Tyr His Val Leu Val Gly Asp Leu Ile Lys Phe Ser Ala 
            180                 185                 190         


Glu Thr Leu Ser Glu Leu Ile Arg Thr Thr Leu Asp Ala Glu Lys Val 
        195                 200                 205             


Phe Thr Gln Gly Leu Asn Ile Leu Glu Trp Leu Glu Asn Pro Ser Asn 
    210                 215                 220                 


Thr Pro Asp Lys Asp Tyr Leu Leu Ser Ile Pro Ile Ser Cys Pro Leu 
225                 230                 235                 240 


Ile Gly Val Ile Gln Leu Ala His Tyr Val Val Thr Ala Lys Leu Leu 
                245                 250                 255     


Gly Phe Thr Pro Gly Glu Leu Arg Ser Tyr Leu Lys Gly Ala Thr Gly 
            260                 265                 270         


His Ser Gln Gly Leu Val Thr Ala Val Ala Ile Ala Glu Thr Asp Ser 
        275                 280                 285             


Trp Glu Ser Phe Phe Val Ser Val Arg Lys Ala Ile Thr Val Leu Phe 
    290                 295                 300                 


Phe Ile Gly Val Arg Cys Tyr Glu Ala Tyr Pro Asn Thr Ser Leu Pro 
305                 310                 315                 320 


Pro Ser Ile Leu Glu Asp Ser Leu Glu Asn Asn Glu Gly Val Pro Ser 
                325                 330                 335     


Pro Met Leu Ser Ile Ser Asn Leu Thr Gln Glu Gln Val Gln Asp Tyr 
            340                 345                 350         


Val Asn Lys Thr Asn Ser His Leu Pro Ala Gly Lys Gln Val Glu Ile 
        355                 360                 365             


Ser Leu Val Asn Gly Ala Lys Asn Leu Val Val Ser Gly Pro Pro Gln 
    370                 375                 380                 


Ser Leu Tyr Gly Leu Asn Leu Thr Leu Arg Lys Ala Lys Ala Pro Ser 
385                 390                 395                 400 


Gly Leu Asp Gln Ser Arg Ile Pro Phe Ser Glu Arg Lys Leu Lys Phe 
                405                 410                 415     


Ser Asn Arg Phe Leu Pro Val Ala Ser Pro Phe His Ser His Leu Leu 
            420                 425                 430         


Val Pro Ala Ser Asp Leu Ile Asn Lys Asp Leu Val Lys Asn Asn Val 
        435                 440                 445             


Ser Phe Asn Ala Lys Asp Ile Gln Ile Pro Val Tyr Asp Thr Phe Asp 
    450                 455                 460                 


Gly Ser Asp Leu Arg Val Leu Ser Gly Ser Ile Ser Glu Arg Ile Val 
465                 470                 475                 480 


Asp Cys Ile Ile Arg Leu Pro Val Lys Trp Glu Thr Thr Thr Gln Phe 
                485                 490                 495     


Lys Ala Thr His Ile Leu Asp Phe Gly Pro Gly Gly Ala Ser Gly Leu 
            500                 505                 510         


Gly Val Leu Thr His Arg Asn Lys Asp Gly Thr Gly Val Arg Val Ile 
        515                 520                 525             


Val Ala Gly Thr Leu Asp Ile Asn Pro Asp Asp Asp Tyr Gly Phe Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Val Thr Ser Asn Gly Leu Lys Lys Asn Pro Asn 
545                 550                 555                 560 


Trp Leu Glu Glu Tyr His Pro Lys Leu Ile Lys Asn Lys Ser Gly Lys 
                565                 570                 575     


Ile Phe Val Glu Thr Lys Phe Ser Lys Leu Ile Gly Arg Pro Pro Leu 
            580                 585                 590         


Leu Val Pro Gly Met Thr Pro Cys Thr Val Ser Pro Asp Phe Val Ala 
        595                 600                 605             


Ala Thr Thr Asn Ala Gly Tyr Thr Ile Glu Leu Ala Gly Gly Gly Tyr 
    610                 615                 620                 


Phe Ser Ala Ala Gly Met Thr Ala Ala Ile Asp Ser Val Val Ser Gln 
625                 630                 635                 640 


Ile Glu Lys Gly Ser Thr Phe Gly Ile Asn Leu Ile Tyr Val Asn Pro 
                645                 650                 655     


Phe Met Leu Gln Trp Gly Ile Pro Leu Ile Lys Glu Leu Arg Ser Lys 
            660                 665                 670         


Gly Tyr Pro Ile Gln Phe Leu Thr Ile Gly Ala Gly Val Pro Ser Leu 
        675                 680                 685             


Glu Val Ala Ser Glu Tyr Ile Glu Thr Leu Gly Leu Lys Tyr Leu Gly 
    690                 695                 700                 


Leu Lys Pro Gly Ser Ile Asp Ala Ile Ser Gln Val Ile Asn Ile Ala 
705                 710                 715                 720 


Lys Ala His Pro Asn Phe Pro Ile Ala Leu Gln Trp Thr Gly Gly Arg 
                725                 730                 735     


Gly Gly Gly His His Ser Phe Glu Asp Ala His Thr Pro Met Leu Gln 
            740                 745                 750         


Met Tyr Ser Lys Ile Arg Arg His Pro Asn Ile Met Leu Ile Phe Gly 
        755                 760                 765             


Ser Gly Phe Gly Ser Ala Asp Asp Thr Tyr Pro Tyr Leu Thr Gly Glu 
    770                 775                 780                 


Trp Ser Thr Lys Phe Asp Tyr Pro Pro Met Pro Phe Asp Gly Phe Leu 
785                 790                 795                 800 


Phe Gly Ser Arg Val Met Ile Ala Lys Glu Val Lys Thr Ser Pro Asp 
                805                 810                 815     


Ala Lys Lys Cys Ile Ala Ala Cys Thr Gly Val Pro Asp Asp Lys Trp 
            820                 825                 830         


Glu Gln Thr Tyr Lys Lys Pro Thr Gly Gly Ile Val Thr Val Arg Ser 
        835                 840                 845             


Glu Met Gly Glu Pro Ile His Lys Ile Ala Thr Arg Gly Val Met Leu 
    850                 855                 860                 


Trp Lys Glu Phe Asp Glu Thr Ile Phe Asn Leu Pro Lys Asn Lys Leu 
865                 870                 875                 880 


Val Pro Thr Leu Glu Ala Lys Arg Asp Tyr Ile Ile Ser Arg Leu Asn 
                885                 890                 895     


Ala Asp Phe Gln Lys Pro Trp Phe Ala Thr Val Asn Gly Gln Ala Arg 
            900                 905                 910         


Asp Leu Ala Thr Met Thr Tyr Glu Glu Val Ala Lys Arg Leu Val Glu 
        915                 920                 925             


Leu Met Phe Ile Arg Ser Thr Asn Ser Trp Phe Asp Val Thr Trp Arg 
    930                 935                 940                 


Thr Phe Thr Gly Asp Phe Leu Arg Arg Val Glu Glu Arg Phe Thr Lys 
945                 950                 955                 960 


Ser Lys Thr Leu Ser Leu Ile Gln Ser Tyr Ser Leu Leu Asp Lys Pro 
                965                 970                 975     


Asp Glu Ala Ile Glu Lys Val Phe Asn Ala Tyr Pro Ala Ala Arg Glu 
            980                 985                 990         


Gln Phe Leu Asn Ala Gln Asp Ile  Asp His Phe Leu Ser  Met Cys Gln 
        995                 1000                 1005             


Asn Pro  Met Gln Lys Pro Val  Pro Phe Val Pro Val  Leu Asp Arg 
    1010                 1015                 1020             


Arg Phe  Glu Ile Phe Phe Lys  Lys Asp Ser Leu Trp  Gln Ser Glu 
    1025                 1030                 1035             


His Leu  Glu Ala Val Val Asp  Gln Asp Val Gln Arg  Thr Cys Ile 
    1040                 1045                 1050             


Leu His  Gly Pro Val Ala Ala  Gln Phe Thr Lys Val  Ile Asp Glu 
    1055                 1060                 1065             


Pro Ile  Lys Ser Ile Met Asp  Gly Ile His Asp Gly  His Ile Lys 
    1070                 1075                 1080             


Lys Leu  Leu His Gln Tyr Tyr  Gly Asp Asp Glu Ser  Lys Ile Pro 
    1085                 1090                 1095             


Ala Val  Glu Tyr Phe Gly Gly  Glu Ser Pro Val Asp  Val Gln Ser 
    1100                 1105                 1110             


Gln Val  Asp Ser Ser Ser Val  Ser Glu Asp Ser Ala  Val Phe Lys 
    1115                 1120                 1125             


Ala Thr  Ser Ser Thr Asp Glu  Glu Ser Trp Phe Lys  Ala Leu Ala 
    1130                 1135                 1140             


Gly Ser  Glu Ile Asn Trp Arg  His Ala Ser Phe Leu  Cys Ser Phe 
    1145                 1150                 1155             


Ile Thr  Gln Asp Lys Met Phe  Val Ser Asn Pro Ile  Arg Lys Val 
    1160                 1165                 1170             


Phe Lys  Pro Ser Gln Gly Met  Val Val Glu Ile Ser  Asn Gly Asn 
    1175                 1180                 1185             


Thr Ser  Ser Lys Thr Val Val  Thr Leu Ser Glu Pro  Val Gln Gly 
    1190                 1195                 1200             


Glu Leu  Lys Pro Thr Val Ile  Leu Lys Leu Leu Lys  Glu Asn Ile 
    1205                 1210                 1215             


Ile Gln  Met Glu Met Ile Glu  Asn Arg Thr Met Asp  Gly Lys Pro 
    1220                 1225                 1230             


Val Ser  Leu Pro Leu Leu Tyr  Asn Phe Asn Pro Asp  Asn Gly Phe 
    1235                 1240                 1245             


Ala Pro  Ile Ser Glu Val Met  Glu Asp Arg Asn Gln  Arg Ile Lys 
    1250                 1255                 1260             


Glu Met  Tyr Trp Lys Leu Trp  Ile Asp Glu Pro Phe  Asn Leu Asp 
    1265                 1270                 1275             


Phe Asp  Pro Arg Asp Val Ile  Lys Gly Lys Asp Phe  Glu Ile Thr 
    1280                 1285                 1290             


Ala Lys  Glu Val Tyr Asp Phe  Thr His Ala Val Gly  Asn Asn Cys 
    1295                 1300                 1305             


Glu Asp  Phe Val Ser Arg Pro  Asp Arg Thr Met Leu  Ala Pro Met 
    1310                 1315                 1320             


Asp Phe  Ala Ile Val Val Gly  Trp Arg Ala Ile Ile  Lys Ala Ile 
    1325                 1330                 1335             


Phe Pro  Asn Thr Val Asp Gly  Asp Leu Leu Lys Leu  Val His Leu 
    1340                 1345                 1350             


Ser Asn  Gly Tyr Lys Met Ile  Pro Gly Ala Lys Pro  Leu Gln Val 
    1355                 1360                 1365             


Gly Asp  Val Val Ser Thr Thr  Ala Val Ile Glu Ser  Val Val Asn 
    1370                 1375                 1380             


Gln Pro  Thr Gly Lys Ile Val  Asp Val Val Gly Thr  Leu Ser Arg 
    1385                 1390                 1395             


Asn Gly  Lys Pro Val Met Glu  Val Thr Ser Ser Phe  Phe Tyr Arg 
    1400                 1405                 1410             


Gly Asn  Tyr Thr Asp Phe Glu  Asn Thr Phe Gln Lys  Thr Val Glu 
    1415                 1420                 1425             


Pro Val  Tyr Gln Met His Ile  Lys Thr Ser Lys Asp  Ile Ala Val 
    1430                 1435                 1440             


Leu Arg  Ser Lys Glu Trp Phe  Gln Leu Asp Asp Glu  Asp Phe Asp 
    1445                 1450                 1455             


Leu Leu  Asn Lys Thr Leu Thr  Phe Glu Thr Glu Thr  Glu Val Thr 
    1460                 1465                 1470             


Phe Lys  Asn Ala Asn Ile Phe  Ser Ser Val Lys Cys  Phe Gly Pro 
    1475                 1480                 1485             


Ile Lys  Val Glu Leu Pro Thr  Lys Glu Thr Val Glu  Ile Gly Ile 
    1490                 1495                 1500             


Val Asp  Tyr Glu Ala Gly Ala  Ser His Gly Asn Pro  Val Val Asp 
    1505                 1510                 1515             


Phe Leu  Lys Arg Asn Gly Ser  Thr Leu Glu Gln Lys  Val Asn Leu 
    1520                 1525                 1530             


Glu Asn  Pro Ile Pro Ile Ala  Val Leu Asp Ser Tyr  Thr Pro Ser 
    1535                 1540                 1545             


Thr Asn  Glu Pro Tyr Ala Arg  Val Ser Gly Asp Leu  Asn Pro Ile 
    1550                 1555                 1560             


His Val  Ser Arg His Phe Ala  Ser Tyr Ala Asn Leu  Pro Gly Thr 
    1565                 1570                 1575             


Ile Thr  His Gly Met Phe Ser  Ser Ala Ser Val Arg  Ala Leu Ile 
    1580                 1585                 1590             


Glu Asn  Trp Ala Ala Asp Ser  Val Ser Ser Arg Val  Arg Gly Tyr 
    1595                 1600                 1605             


Thr Cys  Gln Phe Val Asp Met  Val Leu Pro Asn Thr  Ala Leu Lys 
    1610                 1615                 1620             


Thr Ser  Ile Gln His Val Gly  Met Ile Asn Gly Arg  Lys Leu Ile 
    1625                 1630                 1635             


Lys Phe  Glu Thr Arg Asn Glu  Asp Asp Val Val Val  Leu Thr Gly 
    1640                 1645                 1650             


Glu Ala  Glu Ile Glu Gln Pro  Val Thr Thr Phe Val  Phe Thr Gly 
    1655                 1660                 1665             


Gln Gly  Ser Gln Glu Gln Gly  Met Gly Met Asp Leu  Tyr Lys Thr 
    1670                 1675                 1680             


Ser Lys  Ala Ala Gln Asp Val  Trp Asn Arg Ala Asp  Asn His Phe 
    1685                 1690                 1695             


Lys Asp  Thr Tyr Gly Phe Ser  Ile Leu Asp Ile Val  Ile Asn Asn 
    1700                 1705                 1710             


Pro Val  Asn Leu Thr Ile His  Phe Gly Gly Glu Lys  Gly Lys Arg 
    1715                 1720                 1725             


Ile Arg  Glu Asn Tyr Ser Ala  Met Ile Phe Glu Thr  Ile Val Asp 
    1730                 1735                 1740             


Gly Lys  Leu Lys Thr Glu Lys  Ile Phe Lys Glu Ile  Asn Glu His 
    1745                 1750                 1755             


Ser Thr  Ser Tyr Thr Phe Arg  Ser Glu Lys Gly Leu  Leu Ser Ala 
    1760                 1765                 1770             


Thr Gln  Phe Thr Gln Pro Ala  Leu Thr Leu Met Glu  Lys Ala Ala 
    1775                 1780                 1785             


Phe Glu  Asp Leu Lys Ser Lys  Gly Leu Ile Pro Ala  Asp Ala Thr 
    1790                 1795                 1800             


Phe Ala  Gly His Ser Leu Gly  Glu Tyr Ala Ala Leu  Ala Ser Leu 
    1805                 1810                 1815             


Ala Asp  Val Met Ser Ile Glu  Ser Leu Val Glu Val  Val Phe Tyr 
    1820                 1825                 1830             


Arg Gly  Met Thr Met Gln Val  Ala Val Pro Arg Asp  Glu Leu Gly 
    1835                 1840                 1845             


Arg Ser  Asn Tyr Gly Met Ile  Ala Ile Asn Pro Gly  Arg Val Ala 
    1850                 1855                 1860             


Ala Ser  Phe Ser Gln Glu Ala  Leu Gln Tyr Val Val  Glu Arg Val 
    1865                 1870                 1875             


Gly Lys  Arg Thr Gly Trp Leu  Val Glu Ile Val Asn  Tyr Asn Val 
    1880                 1885                 1890             


Glu Asn  Gln Gln Tyr Val Ala  Ala Gly Asp Leu Arg  Ala Leu Asp 
    1895                 1900                 1905             


Thr Val  Thr Asn Val Leu Asn  Phe Ile Lys Leu Gln  Lys Ile Asp 
    1910                 1915                 1920             


Ile Ile  Glu Leu Gln Lys Ser  Leu Ser Leu Glu Glu  Val Glu Gly 
    1925                 1930                 1935             


His Leu  Phe Glu Ile Ile Asp  Glu Ala Ser Lys Lys  Ser Ala Val 
    1940                 1945                 1950             


Lys Pro  Arg Pro Leu Lys Leu  Glu Arg Gly Phe Ala  Cys Ile Pro 
    1955                 1960                 1965             


Leu Val  Gly Ile Ser Val Pro  Phe His Ser Thr Tyr  Leu Met Asn 
    1970                 1975                 1980             


Gly Val  Lys Pro Phe Lys Ser  Phe Leu Lys Lys Asn  Ile Ile Lys 
    1985                 1990                 1995             


Glu Asn  Val Lys Val Ala Arg  Leu Ala Gly Lys Tyr  Ile Pro Asn 
    2000                 2005                 2010             


Leu Thr  Ala Lys Pro Phe Gln  Val Thr Lys Glu Tyr  Phe Gln Asp 
    2015                 2020                 2025             


Val Tyr  Asp Leu Thr Gly Ser  Glu Pro Ile Lys Glu  Ile Ile Asp 
    2030                 2035                 2040             


Asn Trp  Glu Lys Tyr Glu Gln  Ser 
    2045                 2050     


<210>  7
<211>  2073
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  7

Met Val Glu Ala Glu Gln Val His Gln Ser Leu Arg Ser Leu Val Leu 
1               5                   10                  15      


Ser Tyr Ala His Phe Ser Pro Ser Ile Leu Ile Pro Ala Ser Gln Tyr 
            20                  25                  30          


Leu Leu Ala Ala Gln Leu Arg Asp Glu Phe Leu Ser Leu His Pro Ala 
        35                  40                  45              


Pro Ser Ala Glu Ser Val Glu Lys Glu Gly Ala Glu Leu Glu Phe Glu 
    50                  55                  60                  


His Glu Leu His Leu Leu Ala Gly Phe Leu Gly Leu Ile Ala Ala Lys 
65                  70                  75                  80  


Glu Glu Glu Thr Pro Gly Gln Tyr Thr Gln Leu Leu Arg Ile Ile Thr 
                85                  90                  95      


Leu Glu Phe Glu Arg Thr Phe Leu Ala Gly Asn Glu Val His Ala Val 
            100                 105                 110         


Val His Ser Leu Gly Leu Asn Ile Pro Ala Gln Lys Asp Val Val Arg 
        115                 120                 125             


Phe Tyr Tyr His Ser Cys Ala Leu Ile Gly Gln Thr Thr Lys Phe His 
    130                 135                 140                 


Gly Ser Ala Leu Leu Asp Glu Ser Ser Val Lys Leu Ala Ala Ile Phe 
145                 150                 155                 160 


Gly Gly Gln Gly Tyr Glu Asp Tyr Phe Asp Glu Leu Ile Glu Leu Tyr 
                165                 170                 175     


Glu Val Tyr Ala Pro Phe Ala Ala Glu Leu Ile Gln Val Leu Ser Lys 
            180                 185                 190         


His Leu Phe Thr Leu Ser Gln Asn Glu Gln Ala Ser Lys Val Tyr Ser 
        195                 200                 205             


Lys Gly Leu Asn Val Leu Asp Trp Leu Ala Gly Glu Arg Pro Glu Arg 
    210                 215                 220                 


Asp Tyr Leu Val Ser Ala Pro Val Ser Leu Pro Leu Val Gly Leu Thr 
225                 230                 235                 240 


Gln Leu Val His Phe Ser Val Thr Ala Gln Ile Leu Gly Leu Asn Pro 
                245                 250                 255     


Gly Glu Leu Ala Ser Arg Phe Ser Ala Ala Ser Gly His Ser Gln Gly 
            260                 265                 270         


Ile Val Val Ala Ala Ala Val Ser Ala Ser Thr Asp Ser Ala Ser Phe 
        275                 280                 285             


Met Glu Asn Ala Lys Val Ala Leu Thr Thr Leu Phe Trp Ile Gly Val 
    290                 295                 300                 


Arg Ser Gln Gln Thr Phe Pro Thr Thr Thr Leu Pro Pro Ser Val Val 
305                 310                 315                 320 


Ala Asp Ser Leu Ala Ser Ser Glu Gly Asn Pro Thr Pro Met Leu Ala 
                325                 330                 335     


Val Arg Asp Leu Pro Ile Glu Thr Leu Asn Lys His Ile Glu Thr Thr 
            340                 345                 350         


Asn Thr His Leu Pro Glu Asp Arg Lys Val Ser Leu Ser Leu Val Asn 
        355                 360                 365             


Gly Pro Arg Ser Phe Val Val Ser Gly Pro Ala Arg Ser Leu Tyr Gly 
    370                 375                 380                 


Leu Asn Leu Ser Leu Arg Lys Glu Lys Ala Asp Gly Gln Asn Gln Ser 
385                 390                 395                 400 


Arg Ile Pro His Ser Lys Arg Lys Leu Arg Phe Ile Asn Arg Phe Leu 
                405                 410                 415     


Ser Ile Ser Val Pro Phe His Ser Pro Tyr Leu Ala Pro Val Arg Ser 
            420                 425                 430         


Leu Leu Glu Lys Asp Leu Gln Gly Leu Gln Phe Ser Ala Leu Lys Val 
        435                 440                 445             


Pro Val Tyr Ser Thr Asp Asp Ala Gly Asp Leu Arg Phe Glu Gln Pro 
    450                 455                 460                 


Ser Lys Leu Leu Leu Ala Leu Ala Val Met Ile Thr Glu Lys Val Val 
465                 470                 475                 480 


His Trp Glu Glu Ala Cys Gly Phe Pro Asp Val Thr His Ile Ile Asp 
                485                 490                 495     


Phe Gly Pro Gly Gly Ile Ser Gly Val Gly Ser Leu Thr Arg Ala Asn 
            500                 505                 510         


Lys Asp Gly Gln Gly Val Arg Val Ile Val Ala Asp Ser Phe Glu Ser 
        515                 520                 525             


Leu Asp Met Gly Ala Lys Phe Glu Ile Phe Asp Arg Asp Ala Lys Ser 
    530                 535                 540                 


Ile Glu Phe Ala Pro Asn Trp Val Lys Leu Tyr Ser Pro Lys Leu Val 
545                 550                 555                 560 


Lys Asn Lys Leu Gly Arg Val Tyr Val Asp Thr Arg Leu Ser Arg Met 
                565                 570                 575     


Leu Gly Leu Pro Pro Leu Trp Val Ala Gly Met Thr Pro Thr Ser Val 
            580                 585                 590         


Pro Trp Gln Phe Cys Ser Ala Ile Ala Lys Ala Gly Phe Thr Tyr Glu 
        595                 600                 605             


Leu Ala Gly Gly Gly Tyr Phe Asp Pro Lys Met Met Arg Glu Ala Ile 
    610                 615                 620                 


His Lys Leu Ser Leu Asn Ile Pro Pro Gly Ala Gly Ile Cys Val Asn 
625                 630                 635                 640 


Val Ile Tyr Ile Asn Pro Arg Thr Tyr Ala Trp Gln Ile Pro Leu Ile 
                645                 650                 655     


Arg Asp Met Val Ala Glu Gly Tyr Pro Ile Arg Gly Val Thr Ile Ala 
            660                 665                 670         


Ala Gly Ile Pro Ser Leu Glu Val Ala Asn Glu Leu Ile Ser Thr Leu 
        675                 680                 685             


Gly Val Gln Tyr Leu Cys Leu Lys Pro Gly Ser Val Glu Ala Val Asn 
    690                 695                 700                 


Ala Val Ile Ser Ile Ala Lys Ala Asn Pro Thr Phe Pro Ile Val Leu 
705                 710                 715                 720 


Gln Trp Thr Gly Gly Arg Ala Gly Gly His His Ser Phe Glu Asp Phe 
                725                 730                 735     


His Ser Pro Ile Leu Leu Thr Tyr Ser Ala Ile Arg Arg Cys Asp Asn 
            740                 745                 750         


Ile Val Leu Ile Ala Gly Ser Gly Phe Gly Gly Ala Asp Asp Thr Glu 
        755                 760                 765             


Pro Tyr Leu Thr Gly Glu Trp Ser Ala Ala Phe Lys Leu Pro Pro Met 
    770                 775                 780                 


Pro Phe Asp Gly Ile Leu Phe Gly Ser Arg Leu Met Val Ala Lys Glu 
785                 790                 795                 800 


Ala His Thr Ser Leu Ala Ala Lys Glu Ala Ile Val Ala Ala Lys Gly 
                805                 810                 815     


Val Asp Asp Ser Glu Trp Glu Lys Thr Tyr Asp Gly Pro Thr Gly Gly 
            820                 825                 830         


Ile Val Thr Val Leu Ser Glu Leu Gly Glu Pro Ile His Lys Leu Ala 
        835                 840                 845             


Thr Arg Gly Ile Met Phe Trp Lys Glu Leu Asp Asp Thr Ile Phe Ser 
    850                 855                 860                 


Leu Pro Arg Pro Lys Arg Leu Pro Ala Leu Leu Ala Lys Lys Gln Tyr 
865                 870                 875                 880 


Ile Ile Lys Arg Leu Asn Asp Asp Phe Gln Lys Val Tyr Phe Pro Ala 
                885                 890                 895     


His Ile Val Glu Gln Val Ser Pro Glu Lys Phe Lys Phe Glu Ala Val 
            900                 905                 910         


Asp Ser Val Glu Asp Met Thr Tyr Ala Glu Leu Leu Tyr Arg Ala Ile 
        915                 920                 925             


Asp Leu Met Tyr Val Thr Lys Glu Lys Arg Trp Ile Asp Val Thr Leu 
    930                 935                 940                 


Arg Thr Phe Thr Gly Lys Leu Met Arg Arg Ile Glu Glu Arg Phe Thr 
945                 950                 955                 960 


Gln Asp Val Gly Lys Thr Thr Leu Ile Glu Asn Phe Glu Asp Leu Asn 
                965                 970                 975     


Asp Pro Tyr Pro Val Ala Ala Arg Phe Leu Asp Ala Tyr Pro Glu Ala 
            980                 985                 990         


Ser Thr Gln Asp Leu Asn Thr Gln  Asp Ala Gln Phe Phe  Tyr Ser Leu 
        995                 1000                 1005             


Cys Ser  Asn Pro Phe Gln Lys  Pro Val Pro Phe Ile  Pro Ala Ile 
    1010                 1015                 1020             


Asp Asp  Thr Phe Glu Phe Tyr  Phe Lys Lys Asp Ser  Leu Trp Gln 
    1025                 1030                 1035             


Ser Glu  Asp Leu Ala Ala Val  Val Gly Glu Asp Val  Gly Arg Val 
    1040                 1045                 1050             


Ala Ile  Leu Gln Gly Pro Met  Ala Ala Lys His Ser  Thr Lys Val 
    1055                 1060                 1065             


Asn Glu  Pro Ala Lys Glu Leu  Leu Asp Gly Ile Asn  Glu Thr His 
    1070                 1075                 1080             


Ile Gln  His Phe Ile Lys Lys  Phe Tyr Ala Gly Asp  Glu Lys Lys 
    1085                 1090                 1095             


Ile Pro  Ile Val Glu Tyr Phe  Gly Gly Val Pro Pro  Val Asn Val 
    1100                 1105                 1110             


Ser His  Lys Ser Leu Glu Ser  Val Ser Val Thr Glu  Glu Ala Gly 
    1115                 1120                 1125             


Ser Lys  Val Tyr Lys Leu Pro  Glu Ile Gly Ser Asn  Ser Ala Leu 
    1130                 1135                 1140             


Pro Ser  Lys Lys Leu Trp Phe  Glu Leu Leu Ala Gly  Pro Glu Tyr 
    1145                 1150                 1155             


Thr Trp  Phe Arg Ala Ile Phe  Thr Thr Gln Arg Val  Ala Lys Gly 
    1160                 1165                 1170             


Trp Lys  Leu Glu His Asn Pro  Val Arg Arg Ile Phe  Ala Pro Arg 
    1175                 1180                 1185             


Tyr Gly  Gln Arg Ala Val Val  Lys Gly Lys Asp Asn  Asp Thr Val 
    1190                 1195                 1200             


Val Glu  Leu Tyr Glu Thr Gln  Ser Gly Asn Tyr Val  Leu Ala Ala 
    1205                 1210                 1215             


Arg Leu  Ser Tyr Asp Gly Glu  Thr Ile Val Val Ser  Met Phe Glu 
    1220                 1225                 1230             


Asn Arg  Asn Ala Leu Lys Lys  Glu Val His Leu Asp  Phe Leu Phe 
    1235                 1240                 1245             


Lys Tyr  Glu Pro Ser Ala Gly  Tyr Ser Pro Val Ser  Glu Ile Leu 
    1250                 1255                 1260             


Asp Gly  Arg Asn Asp Arg Ile  Lys His Phe Tyr Trp  Ala Leu Trp 
    1265                 1270                 1275             


Phe Gly  Glu Glu Pro Tyr Pro  Glu Asn Ala Ser Ile  Thr Asp Thr 
    1280                 1285                 1290             


Phe Thr  Gly Pro Glu Val Thr  Val Thr Gly Asn Met  Ile Glu Asp 
    1295                 1300                 1305             


Phe Cys  Arg Thr Val Gly Asn  His Asn Glu Ala Tyr  Thr Lys Arg 
    1310                 1315                 1320             


Ala Ile  Arg Lys Arg Met Ala  Pro Met Asp Phe Ala  Ile Val Val 
    1325                 1330                 1335             


Gly Trp  Gln Ala Ile Thr Lys  Ala Ile Phe Pro Lys  Ala Ile Asp 
    1340                 1345                 1350             


Gly Asp  Leu Leu Arg Leu Val  His Leu Ser Asn Ser  Phe Arg Met 
    1355                 1360                 1365             


Val Gly  Ser His Ser Leu Met  Glu Gly Asp Lys Val  Thr Thr Ser 
    1370                 1375                 1380             


Ala Ser  Ile Ile Ala Ile Leu  Asn Asn Asp Ser Gly  Lys Thr Val 
    1385                 1390                 1395             


Thr Val  Lys Gly Thr Val Tyr  Arg Asp Gly Lys Glu  Val Ile Glu 
    1400                 1405                 1410             


Val Ile  Ser Arg Phe Leu Tyr  Arg Gly Thr Phe Thr  Asp Phe Glu 
    1415                 1420                 1425             


Asn Thr  Phe Glu His Thr Gln  Glu Thr Pro Met Gln  Leu Thr Leu 
    1430                 1435                 1440             


Ala Thr  Pro Lys Asp Val Ala  Val Leu Gln Ser Lys  Ser Trp Phe 
    1445                 1450                 1455             


Gln Leu  Leu Asp Pro Ser Gln  Asp Leu Ser Gly Ser  Ile Leu Thr 
    1460                 1465                 1470             


Phe Arg  Leu Asn Ser Tyr Val  Arg Phe Lys Asp Gln  Lys Val Lys 
    1475                 1480                 1485             


Ser Ser  Val Glu Thr Lys Gly  Ile Val Leu Ser Glu  Leu Pro Ser 
    1490                 1495                 1500             


Lys Ala  Ile Ile Gln Val Ala  Ser Val Asp Phe Gln  Ser Val Asp 
    1505                 1510                 1515             


Cys His  Gly Asn Pro Val Ile  Glu Phe Leu Lys Arg  Asn Gly Lys 
    1520                 1525                 1530             


Pro Ile  Glu Gln Pro Val Glu  Phe Glu Asn Gly Gly  Tyr Ser Val 
    1535                 1540                 1545             


Ile Gln  Val Met Asp Glu Gly  Tyr Ser Pro Val Phe  Val Thr Pro 
    1550                 1555                 1560             


Pro Thr  Asn Ser Pro Tyr Ala  Glu Val Ser Gly Asp  Tyr Asn Pro 
    1565                 1570                 1575             


Ile His  Val Ser Pro Thr Phe  Ala Ala Phe Val Glu  Leu Pro Gly 
    1580                 1585                 1590             


Thr His  Gly Ile Thr His Gly  Met Tyr Thr Ser Ala  Ala Ala Arg 
    1595                 1600                 1605             


Arg Phe  Val Glu Thr Tyr Ala  Ala Gln Asn Val Pro  Glu Arg Val 
    1610                 1615                 1620             


Lys His  Tyr Glu Val Thr Phe  Val Asn Met Val Leu  Pro Asn Thr 
    1625                 1630                 1635             


Glu Leu  Ile Thr Lys Leu Ser  His Thr Gly Met Ile  Asn Gly Arg 
    1640                 1645                 1650             


Lys Ile  Ile Lys Val Glu Val  Leu Asn Gln Glu Thr  Ser Glu Pro 
    1655                 1660                 1665             


Val Leu  Val Gly Thr Ala Glu  Val Glu Gln Pro Val  Ser Ala Tyr 
    1670                 1675                 1680             


Val Phe  Thr Gly Gln Gly Ser  Gln Glu Gln Gly Met  Gly Met Asp 
    1685                 1690                 1695             


Leu Tyr  Ala Ser Ser Pro Val  Ala Arg Lys Ile Trp  Asp Ser Ala 
    1700                 1705                 1710             


Asp Lys  His Phe Leu Thr Asn  Tyr Gly Phe Ser Ile  Ile Asp Ile 
    1715                 1720                 1725             


Val Lys  His Asn Pro His Ser  Ile Thr Ile His Phe  Gly Gly Ser 
    1730                 1735                 1740             


Lys Gly  Lys Lys Ile Arg Asp  Asn Tyr Met Ala Met  Ala Tyr Glu 
    1745                 1750                 1755             


Lys Leu  Met Glu Asp Gly Thr  Ser Lys Val Val Pro  Val Phe Glu 
    1760                 1765                 1770             


Thr Ile  Thr Lys Asp Ser Thr  Ser Phe Ser Phe Thr  His Pro Ser 
    1775                 1780                 1785             


Gly Leu  Leu Ser Ala Thr Gln  Phe Thr Gln Pro Ala  Leu Thr Leu 
    1790                 1795                 1800             


Met Glu  Lys Ser Ala Phe Glu  Asp Met Arg Ser Lys  Gly Leu Val 
    1805                 1810                 1815             


Gln Asn  Asp Cys Ala Phe Ala  Gly His Ser Leu Gly  Glu Tyr Ser 
    1820                 1825                 1830             


Ala Leu  Ser Ala Met Gly Asp  Val Leu Ser Ile Glu  Ala Leu Val 
    1835                 1840                 1845             


Asp Leu  Val Phe Leu Arg Gly  Leu Thr Met Gln Asn  Ala Val His 
    1850                 1855                 1860             


Arg Asp  Glu Leu Gly Arg Ser  Asp Tyr Gly Met Val  Ala Ala Asn 
    1865                 1870                 1875             


Pro Ser  Arg Val Ser Ala Ser  Phe Thr Asp Ala Ala  Leu Arg Phe 
    1880                 1885                 1890             


Ile Val  Asp His Ile Gly Gln  Gln Thr Asn Leu Leu  Leu Glu Ile 
    1895                 1900                 1905             


Val Asn  Tyr Asn Val Glu Asn  Gln Gln Tyr Val Val  Ser Gly Asn 
    1910                 1915                 1920             


Leu Leu  Ser Leu Ser Thr Leu  Gly His Val Leu Asn  Phe Leu Lys 
    1925                 1930                 1935             


Val Gln  Lys Ile Asp Phe Glu  Lys Leu Lys Glu Thr  Leu Thr Ile 
    1940                 1945                 1950             


Glu Gln  Leu Lys Glu Gln Leu  Thr Asp Ile Val Glu  Ala Cys His 
    1955                 1960                 1965             


Ala Lys  Thr Leu Glu Gln Gln  Lys Lys Thr Gly Arg  Ile Glu Leu 
    1970                 1975                 1980             


Glu Arg  Gly Tyr Ala Thr Ile  Pro Leu Lys Ile Asp  Val Pro Phe 
    1985                 1990                 1995             


His Ser  Ser Phe Leu Arg Gly  Gly Val Arg Met Phe  Arg Glu Tyr 
    2000                 2005                 2010             


Leu Val  Lys Lys Ile Phe Pro  His Gln Ile Asn Val  Ala Lys Leu 
    2015                 2020                 2025             


Arg Gly  Lys Tyr Ile Pro Asn  Leu Thr Ala Lys Pro  Phe Glu Ile 
    2030                 2035                 2040             


Ser Lys  Glu Tyr Phe Gln Asn  Val Tyr Asp Leu Thr  Gly Ser Gln 
    2045                 2050                 2055             


Arg Ile  Lys Lys Ile Leu Gln  Asn Trp Asp Glu Tyr  Glu Ser Ser 
    2060                 2065                 2070             


<210>  8
<211>  2086
<212>  PRT
<213>  Yarrowia lipolytica

<400>  8

Met Tyr Pro Thr Thr Gly Val Asn Thr Pro Gln Ser Ala Ala Ser Leu 
1               5                   10                  15      


Arg Pro Leu Val Leu Ser His Gly Gln Thr Glu His Ser Leu Leu Val 
            20                  25                  30          


Pro Thr Ser Leu Tyr Ile Asn Cys Thr Thr Leu Arg Asp Gln Phe Tyr 
        35                  40                  45              


Ala Ser Leu Pro Pro Ala Thr Glu Asp Lys Ala Asp Asp Asp Glu Pro 
    50                  55                  60                  


Ser Ser Ser Thr Glu Leu Leu Ala Ala Phe Leu Gly Phe Thr Ala Lys 
65                  70                  75                  80  


Thr Val Glu Glu Glu Pro Gly Pro Tyr Asp Asp Val Leu Ser Leu Val 
                85                  90                  95      


Leu Asn Glu Phe Glu Thr Arg Tyr Leu Arg Gly Asn Asp Ile His Ala 
            100                 105                 110         


Val Ala Ser Ser Leu Leu Gln Asp Glu Asp Val Pro Thr Thr Val Gly 
        115                 120                 125             


Lys Ile Lys Arg Val Ile Arg Ala Tyr Tyr Ala Ala Arg Ile Ala Cys 
    130                 135                 140                 


Asn Arg Pro Ile Lys Ala His Ser Ser Ala Leu Phe Arg Ala Ala Ser 
145                 150                 155                 160 


Glu Asp Ser Asp Asn Val Ser Leu Tyr Ala Ile Phe Gly Gly Gln Gly 
                165                 170                 175     


Asn Thr Glu Asp Tyr Phe Glu Glu Leu Arg Glu Ile Tyr Asp Ile Tyr 
            180                 185                 190         


Gln Gly Leu Val Gly Asp Phe Ile Arg Glu Cys Gly Ala Gln Leu Leu 
        195                 200                 205             


Ala Leu Ser Arg Asp His Ile Ala Ala Glu Lys Ile Tyr Thr Lys Gly 
    210                 215                 220                 


Phe Asp Ile Val Lys Trp Leu Glu His Pro Glu Thr Ile Pro Asp Phe 
225                 230                 235                 240 


Glu Tyr Leu Ile Ser Ala Pro Ile Ser Val Pro Ile Ile Gly Val Ile 
                245                 250                 255     


Gln Leu Ala His Tyr Ala Val Thr Cys Arg Val Leu Gly Leu Asn Pro 
            260                 265                 270         


Gly Gln Val Arg Asp Asn Leu Lys Gly Ala Thr Gly His Ser Gln Gly 
        275                 280                 285             


Leu Ile Thr Ala Ile Ala Ile Ser Ala Ser Asp Ser Trp Asp Glu Phe 
    290                 295                 300                 


Tyr Asn Ser Ala Ser Arg Ile Leu Lys Ile Phe Phe Phe Ile Gly Val 
305                 310                 315                 320 


Arg Val Gln Gln Ala Tyr Pro Ser Thr Phe Leu Pro Pro Ser Thr Leu 
                325                 330                 335     


Glu Asp Ser Val Lys Gln Gly Glu Gly Lys Pro Thr Pro Met Leu Ser 
            340                 345                 350         


Ile Arg Asp Leu Ser Leu Asn Gln Val Gln Glu Phe Val Asp Ala Thr 
        355                 360                 365             


Asn Leu His Leu Pro Glu Asp Lys Gln Ile Val Val Ser Leu Ile Asn 
    370                 375                 380                 


Gly Pro Arg Asn Val Val Val Thr Gly Pro Pro Gln Ser Leu Tyr Gly 
385                 390                 395                 400 


Leu Cys Leu Val Leu Arg Lys Gln Lys Ala Glu Thr Gly Leu Asp Gln 
                405                 410                 415     


Ser Arg Val Pro His Ser Gln Arg Lys Leu Lys Phe Thr His Arg Phe 
            420                 425                 430         


Leu Pro Ile Thr Ser Pro Phe His Ser Tyr Leu Leu Glu Lys Ser Thr 
        435                 440                 445             


Asp Leu Ile Ile Asn Asp Leu Glu Ser Ser Gly Val Glu Phe Val Ser 
    450                 455                 460                 


Ser Glu Leu Lys Val Pro Val Tyr Asp Thr Phe Asp Gly Ser Val Leu 
465                 470                 475                 480 


Ser Gln Leu Pro Lys Gly Ile Val Ser Arg Leu Val Asn Leu Ile Thr 
                485                 490                 495     


His Leu Pro Val Lys Trp Glu Lys Ala Thr Gln Phe Gln Ala Ser His 
            500                 505                 510         


Ile Val Asp Phe Gly Pro Gly Gly Ala Ser Gly Leu Gly Leu Leu Thr 
        515                 520                 525             


His Lys Asn Lys Asp Gly Thr Gly Val Arg Thr Ile Leu Ala Gly Val 
    530                 535                 540                 


Ile Asp Gln Pro Leu Glu Phe Gly Phe Lys Gln Glu Leu Phe Asp Arg 
545                 550                 555                 560 


Gln Glu Ser Ser Ile Val Phe Ala Gln Asn Trp Ala Lys Glu Phe Ser 
                565                 570                 575     


Pro Lys Leu Val Lys Ile Ser Ser Thr Asn Glu Val Tyr Val Asp Thr 
            580                 585                 590         


Lys Phe Ser Arg Leu Thr Gly Arg Ala Pro Ile Met Val Ala Gly Met 
        595                 600                 605             


Thr Pro Thr Thr Val Asn Pro Lys Phe Val Ala Ala Thr Met Asn Ser 
    610                 615                 620                 


Gly Tyr His Ile Glu Leu Gly Gly Gly Gly Tyr Phe Ala Pro Gly Met 
625                 630                 635                 640 


Met Thr Lys Ala Leu Glu His Ile Glu Lys Asn Thr Pro Pro Gly Ser 
                645                 650                 655     


Gly Ile Thr Ile Asn Leu Ile Tyr Val Asn Pro Arg Leu Ile Gln Trp 
            660                 665                 670         


Gly Ile Pro Leu Ile Gln Glu Leu Arg Gln Lys Gly Phe Pro Ile Glu 
        675                 680                 685             


Gly Leu Thr Ile Gly Ala Gly Val Pro Ser Leu Glu Val Ala Asn Glu 
    690                 695                 700                 


Trp Ile Gln Asp Leu Gly Val Lys His Ile Ala Phe Lys Pro Gly Ser 
705                 710                 715                 720 


Ile Glu Ala Ile Ser Ser Val Ile Arg Ile Ala Lys Ala Asn Pro Asp 
                725                 730                 735     


Phe Pro Ile Ile Leu Gln Trp Thr Gly Gly Arg Gly Gly Gly His His 
            740                 745                 750         


Ser Phe Glu Asp Phe His Ala Pro Ile Leu Gln Met Tyr Ser Lys Ile 
        755                 760                 765             


Arg Arg Cys Ser Asn Ile Val Leu Ile Ala Gly Ser Gly Phe Gly Ala 
    770                 775                 780                 


Ser Thr Asp Ser Tyr Pro Tyr Leu Thr Gly Ser Trp Ser Arg Asp Phe 
785                 790                 795                 800 


Asp Tyr Pro Pro Met Pro Phe Asp Gly Ile Leu Val Gly Ser Arg Val 
                805                 810                 815     


Met Val Ala Lys Glu Ala Phe Thr Ser Leu Gly Ala Lys Gln Leu Ile 
            820                 825                 830         


Val Asp Ser Pro Gly Val Glu Asp Ser Glu Trp Glu Lys Thr Tyr Asp 
        835                 840                 845             


Lys Pro Thr Gly Gly Val Ile Thr Val Leu Ser Glu Met Gly Glu Pro 
    850                 855                 860                 


Ile His Lys Leu Ala Thr Arg Gly Val Leu Phe Trp His Glu Met Asp 
865                 870                 875                 880 


Lys Thr Val Phe Ser Leu Pro Lys Lys Lys Arg Leu Glu Val Leu Lys 
                885                 890                 895     


Ser Lys Arg Ala Tyr Ile Ile Lys Arg Leu Asn Asp Asp Phe Gln Lys 
            900                 905                 910         


Thr Trp Phe Ala Lys Asn Ala Gln Gly Gln Val Cys Asp Leu Glu Asp 
        915                 920                 925             


Leu Thr Tyr Ala Glu Val Ile Gln Arg Leu Val Asp Leu Met Tyr Val 
    930                 935                 940                 


Lys Lys Glu Ser Arg Trp Ile Asp Val Thr Leu Arg Asn Leu Ala Gly 
945                 950                 955                 960 


Thr Phe Ile Arg Arg Val Glu Glu Arg Phe Ser Thr Glu Thr Gly Ala 
                965                 970                 975     


Ser Ser Val Leu Gln Ser Phe Ser Glu Leu Asp Ser Glu Pro Glu Lys 
            980                 985                 990         


Val Val Glu Arg Val Phe Glu Leu  Phe Pro Ala Ser Thr  Thr Gln Ile 
        995                 1000                 1005             


Ile Asn  Ala Gln Asp Lys Asp  His Phe Leu Met Leu  Cys Leu Asn 
    1010                 1015                 1020             


Pro Met  Gln Lys Pro Val Pro  Phe Ile Pro Val Leu  Asp Asp Asn 
    1025                 1030                 1035             


Phe Glu  Phe Phe Phe Lys Lys  Asp Ser Leu Trp Gln  Cys Glu Asp 
    1040                 1045                 1050             


Leu Ala  Ala Val Val Asp Glu  Asp Val Gly Arg Ile  Cys Ile Leu 
    1055                 1060                 1065             


Gln Gly  Pro Val Ala Val Lys  His Ser Lys Ile Val  Asn Glu Pro 
    1070                 1075                 1080             


Val Lys  Glu Ile Leu Asp Ser  Met His Glu Gly His  Ile Lys Gln 
    1085                 1090                 1095             


Leu Leu  Glu Asp Gly Glu Tyr  Ala Gly Asn Met Ala  Asn Ile Pro 
    1100                 1105                 1110             


Gln Val  Glu Cys Phe Gly Gly  Lys Pro Ala Gln Asn  Phe Gly Asp 
    1115                 1120                 1125             


Val Ala  Leu Asp Ser Val Met  Val Leu Asp Asp Leu  Asn Lys Thr 
    1130                 1135                 1140             


Val Phe  Lys Ile Glu Thr Gly  Thr Ser Ala Leu Pro  Ser Ala Ala 
    1145                 1150                 1155             


Asp Trp  Phe Ser Leu Leu Ala  Gly Asp Lys Asn Ser  Trp Arg Gln 
    1160                 1165                 1170             


Val Phe  Leu Ser Thr Asp Thr  Ile Val Gln Thr Thr  Lys Met Ile 
    1175                 1180                 1185             


Ser Asn  Pro Leu His Arg Leu  Leu Glu Pro Ile Ala  Gly Leu Gln 
    1190                 1195                 1200             


Val Glu  Ile Glu His Pro Asp  Glu Pro Glu Asn Thr  Val Ile Ser 
    1205                 1210                 1215             


Ala Phe  Glu Pro Ile Asn Gly  Lys Val Thr Lys Val  Leu Glu Leu 
    1220                 1225                 1230             


Arg Lys  Gly Ala Gly Asp Val  Ile Ser Leu Gln Leu  Ile Glu Ala 
    1235                 1240                 1245             


Arg Gly  Val Asp Arg Val Pro  Val Ala Leu Pro Leu  Glu Phe Lys 
    1250                 1255                 1260             


Tyr Gln  Pro Gln Ile Gly Tyr  Ala Pro Ile Val Glu  Val Met Thr 
    1265                 1270                 1275             


Asp Arg  Asn Thr Arg Ile Lys  Glu Phe Tyr Trp Lys  Leu Trp Phe 
    1280                 1285                 1290             


Gly Gln  Asp Ser Lys Phe Glu  Ile Asp Thr Asp Ile  Thr Glu Glu 
    1295                 1300                 1305             


Ile Ile  Gly Asp Asp Val Thr  Ile Ser Gly Lys Ala  Ile Ala Asp 
    1310                 1315                 1320             


Phe Val  His Ala Val Gly Asn  Lys Gly Glu Ala Phe  Val Gly Arg 
    1325                 1330                 1335             


Ser Thr  Ser Ala Gly Thr Val  Phe Ala Pro Met Asp  Phe Ala Ile 
    1340                 1345                 1350             


Val Leu  Gly Trp Lys Ala Ile  Ile Lys Ala Ile Phe  Pro Arg Ala 
    1355                 1360                 1365             


Ile Asp  Ala Asp Ile Leu Arg  Leu Val His Leu Ser  Asn Gly Phe 
    1370                 1375                 1380             


Lys Met  Met Pro Gly Ala Asp  Pro Leu Gln Met Gly  Asp Val Val 
    1385                 1390                 1395             


Ser Ala  Thr Ala Lys Ile Asp  Thr Val Lys Asn Ser  Ala Thr Gly 
    1400                 1405                 1410             


Lys Thr  Val Ala Val Arg Gly  Leu Leu Thr Arg Asp  Gly Lys Pro 
    1415                 1420                 1425             


Val Met  Glu Val Val Ser Glu  Phe Phe Tyr Arg Gly  Glu Phe Ser 
    1430                 1435                 1440             


Asp Phe  Gln Asn Thr Phe Glu  Arg Arg Glu Glu Val  Pro Met Gln 
    1445                 1450                 1455             


Leu Thr  Leu Lys Asp Ala Lys  Ala Val Ala Ile Leu  Cys Ser Lys 
    1460                 1465                 1470             


Glu Trp  Phe Glu Tyr Asn Gly  Asp Asp Thr Lys Asp  Leu Glu Gly 
    1475                 1480                 1485             


Lys Thr  Ile Val Phe Arg Asn  Ser Ser Phe Ile Lys  Tyr Lys Asn 
    1490                 1495                 1500             


Glu Thr  Val Phe Ser Ser Val  His Thr Thr Gly Lys  Val Leu Met 
    1505                 1510                 1515             


Glu Leu  Pro Ser Lys Glu Val  Ile Glu Ile Ala Thr  Val Asn Tyr 
    1520                 1525                 1530             


Gln Ala  Gly Glu Ser His Gly  Asn Pro Val Ile Asp  Tyr Leu Glu 
    1535                 1540                 1545             


Arg Asn  Gly Thr Thr Ile Glu  Gln Pro Val Glu Phe  Glu Lys Pro 
    1550                 1555                 1560             


Ile Pro  Leu Ser Lys Ala Asp  Asp Leu Leu Ser Phe  Lys Ala Pro 
    1565                 1570                 1575             


Ser Ser  Asn Glu Pro Tyr Ala  Gly Val Ser Gly Asp  Tyr Asn Pro 
    1580                 1585                 1590             


Ile His  Val Ser Arg Ala Phe  Ala Ser Tyr Ala Ser  Leu Pro Gly 
    1595                 1600                 1605             


Thr Ile  Thr His Gly Met Tyr  Ser Ser Ala Ala Val  Arg Ser Leu 
    1610                 1615                 1620             


Ile Glu  Val Trp Ala Ala Glu  Asn Asn Val Ser Arg  Val Arg Ala 
    1625                 1630                 1635             


Phe Ser  Cys Gln Phe Gln Gly  Met Val Leu Pro Asn  Asp Glu Ile 
    1640                 1645                 1650             


Val Thr  Arg Leu Glu His Val  Gly Met Ile Asn Gly  Arg Lys Ile 
    1655                 1660                 1665             


Ile Lys  Val Thr Ser Thr Asn  Arg Glu Thr Glu Ala  Val Val Leu 
    1670                 1675                 1680             


Ser Gly  Glu Ala Glu Val Glu  Gln Pro Ile Ser Thr  Phe Val Phe 
    1685                 1690                 1695             


Thr Gly  Gln Gly Ser Gln Glu  Gln Gly Met Gly Met  Asp Leu Tyr 
    1700                 1705                 1710             


Ala Ser  Ser Glu Val Ala Lys  Lys Val Trp Asp Lys  Ala Asp Glu 
    1715                 1720                 1725             


His Phe  Leu Gln Asn Tyr Gly  Phe Ser Ile Ile Lys  Ile Val Val 
    1730                 1735                 1740             


Glu Asn  Pro Lys Glu Leu Asp  Ile His Phe Gly Gly  Pro Lys Gly 
    1745                 1750                 1755             


Lys Lys  Ile Arg Asp Asn Tyr  Ile Ser Met Met Phe  Glu Thr Ile 
    1760                 1765                 1770             


Asp Glu  Lys Thr Gly Asn Leu  Ile Ser Glu Lys Ile  Phe Lys Glu 
    1775                 1780                 1785             


Ile Asp  Glu Thr Thr Asp Ser  Phe Thr Phe Lys Ser  Pro Thr Gly 
    1790                 1795                 1800             


Leu Leu  Ser Ala Thr Gln Phe  Thr Gln Pro Ala Leu  Thr Leu Met 
    1805                 1810                 1815             


Glu Lys  Ala Ser Phe Glu Asp  Met Lys Ala Lys Gly  Leu Val Pro 
    1820                 1825                 1830             


Val Asp  Ala Thr Phe Ala Gly  His Ser Leu Gly Glu  Tyr Ser Ala 
    1835                 1840                 1845             


Leu Ala  Ser Leu Gly Asp Val  Met Pro Ile Glu Ser  Leu Val Asp 
    1850                 1855                 1860             


Val Val  Phe Tyr Arg Gly Met  Thr Met Gln Val Ala  Val Pro Arg 
    1865                 1870                 1875             


Asp Ala  Gln Gly Arg Ser Asn  Tyr Gly Met Cys Ala  Val Asn Pro 
    1880                 1885                 1890             


Ser Arg  Ile Ser Thr Thr Phe  Asn Asp Ala Ala Leu  Arg Phe Val 
    1895                 1900                 1905             


Val Asp  His Ile Ser Glu Gln  Thr Lys Trp Leu Leu  Glu Ile Val 
    1910                 1915                 1920             


Asn Tyr  Asn Val Glu Asn Ser  Gln Tyr Val Thr Ala  Gly Asp Leu 
    1925                 1930                 1935             


Arg Ala  Leu Asp Thr Leu Thr  Asn Val Leu Asn Val  Leu Lys Leu 
    1940                 1945                 1950             


Glu Lys  Ile Asn Ile Asp Lys  Leu Leu Glu Ser Leu  Pro Leu Glu 
    1955                 1960                 1965             


Lys Val  Lys Glu His Leu Ser  Glu Ile Val Thr Glu  Val Ala Lys 
    1970                 1975                 1980             


Lys Ser  Val Ala Lys Pro Gln  Pro Ile Glu Leu Glu  Arg Gly Phe 
    1985                 1990                 1995             


Ala Val  Ile Pro Leu Lys Gly  Ile Ser Val Pro Phe  His Ser Ser 
    2000                 2005                 2010             


Tyr Leu  Arg Asn Gly Val Lys  Pro Phe Gln Asn Phe  Leu Val Lys 
    2015                 2020                 2025             


Lys Val  Pro Lys Asn Ala Val  Lys Pro Ala Asn Leu  Ile Gly Lys 
    2030                 2035                 2040             


Tyr Ile  Pro Asn Leu Thr Ala  Lys Pro Phe Glu Ile  Thr Lys Glu 
    2045                 2050                 2055             


Tyr Phe  Glu Glu Val Tyr Lys  Leu Thr Gly Ser Glu  Lys Val Lys 
    2060                 2065                 2070             


Ser Ile  Ile Asn Asn Trp Glu  Ser Tyr Glu Ser Lys  Gln 
    2075                 2080                 2085     


<210>  9
<211>  317
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Tyr Thr Lys Ile Ile Gly Thr Gly Ser Tyr Leu Pro Glu Gln Val 
1               5                   10                  15      


Arg Thr Asn Ala Asp Leu Glu Lys Met Val Asp Thr Ser Asp Glu Trp 
            20                  25                  30          


Ile Val Thr Arg Thr Gly Ile Arg Glu Arg His Ile Ala Ala Pro Asn 
        35                  40                  45              


Glu Thr Val Ser Thr Met Gly Phe Glu Ala Ala Thr Arg Ala Ile Glu 
    50                  55                  60                  


Met Ala Gly Ile Glu Lys Asp Gln Ile Gly Leu Ile Val Val Ala Thr 
65                  70                  75                  80  


Thr Ser Ala Thr His Ala Phe Pro Ser Ala Ala Cys Gln Ile Gln Ser 
                85                  90                  95      


Met Leu Gly Ile Lys Gly Cys Pro Ala Phe Asp Val Ala Ala Ala Cys 
            100                 105                 110         


Ala Gly Phe Thr Tyr Ala Leu Ser Val Ala Asp Gln Tyr Val Lys Ser 
        115                 120                 125             


Gly Ala Val Lys Tyr Ala Leu Val Val Gly Ser Asp Val Leu Ala Arg 
    130                 135                 140                 


Thr Cys Asp Pro Thr Asp Arg Gly Thr Ile Ile Ile Phe Gly Asp Gly 
145                 150                 155                 160 


Ala Gly Ala Ala Val Leu Ala Ala Ser Glu Glu Pro Gly Ile Ile Ser 
                165                 170                 175     


Thr His Leu His Ala Asp Gly Ser Tyr Gly Glu Leu Leu Thr Leu Pro 
            180                 185                 190         


Asn Ala Asp Arg Val Asn Pro Glu Asn Ser Ile His Leu Thr Met Ala 
        195                 200                 205             


Gly Asn Glu Val Phe Lys Val Ala Val Thr Glu Leu Ala His Ile Val 
    210                 215                 220                 


Asp Glu Thr Leu Ala Ala Asn Asn Leu Asp Arg Ser Gln Leu Asp Trp 
225                 230                 235                 240 


Leu Val Pro His Gln Ala Asn Leu Arg Ile Ile Ser Ala Thr Ala Lys 
                245                 250                 255     


Lys Leu Gly Met Ser Met Asp Asn Val Val Val Thr Leu Asp Arg His 
            260                 265                 270         


Gly Asn Thr Ser Ala Ala Ser Val Pro Cys Ala Leu Asp Glu Ala Val 
        275                 280                 285             


Arg Asp Gly Arg Ile Lys Pro Gly Gln Leu Val Leu Leu Glu Ala Phe 
    290                 295                 300                 


Gly Gly Gly Phe Thr Trp Gly Ser Ala Leu Val Arg Phe 
305                 310                 315         


<210>  10
<211>  403
<212>  PRT
<213>  Aloe arborescens

<400>  10

Met Ser Ser Leu Ser Asn Ala Ser His Leu Met Glu Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Arg Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu 
        195                 200                 205             


Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly 
            260                 265                 270         


Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Arg Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser 
            340                 345                 350         


Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Asp 
        355                 360                 365             


Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Leu Met 
            


<210>  11
<211>  393
<212>  PRT
<213>  Hypericum perforatum

<400>  11

Met Gly Ser Leu Asp Asn Gly Ser Ala Arg Ile Asn Asn Gln Lys Ser 
1               5                   10                  15      


Asn Gly Leu Ala Ser Ile Leu Ala Ile Gly Thr Ala Leu Pro Pro Ile 
            20                  25                  30          


Cys Ile Lys Gln Asp Asp Tyr Pro Asp Tyr Tyr Phe Arg Val Thr Lys 
        35                  40                  45              


Ser Asp His Lys Thr Gln Leu Lys Glu Lys Phe Arg Arg Ile Cys Glu 
    50                  55                  60                  


Lys Ser Gly Val Thr Lys Arg Tyr Thr Val Leu Thr Glu Asp Met Ile 
65                  70                  75                  80  


Lys Glu Asn Glu Asn Ile Ile Thr Tyr Lys Ala Pro Ser Leu Asp Ala 
                85                  90                  95      


Arg Gln Ala Ile Leu His Lys Glu Thr Pro Lys Leu Ala Ile Glu Ala 
            100                 105                 110         


Ala Leu Lys Thr Ile Gln Glu Trp Gly Gln Pro Val Ser Lys Ile Thr 
        115                 120                 125             


His Leu Phe Phe Cys Ser Ser Ser Gly Gly Cys Tyr Leu Pro Ser Ser 
    130                 135                 140                 


Asp Phe Gln Ile Ala Lys Ala Leu Gly Leu Glu Pro Thr Val Gln Arg 
145                 150                 155                 160 


Ser Met Val Phe Pro His Gly Cys Tyr Ala Ala Ser Ser Gly Leu Arg 
                165                 170                 175     


Leu Ala Lys Asp Ile Ala Glu Asn Asn Lys Asp Ala Arg Val Leu Val 
            180                 185                 190         


Val Cys Cys Glu Leu Met Val Ser Ser Phe His Ala Pro Ser Glu Asp 
        195                 200                 205             


Ala Ile Gly Met Leu Ile Gly His Ala Ile Phe Gly Asp Gly Ala Ala 
    210                 215                 220                 


Cys Ala Ile Val Gly Ala Asp Pro Gly Pro Thr Glu Arg Pro Ile Phe 
225                 230                 235                 240 


Glu Leu Val Lys Gly Gly Gln Val Ile Val Pro Asp Thr Glu Asp Cys 
                245                 250                 255     


Leu Gly Gly Trp Val Met Glu Met Gly Trp Ile Tyr Asp Leu Asn Lys 
            260                 265                 270         


Arg Leu Pro Gln Ala Leu Ala Asp Asn Ile Leu Gly Ala Leu Asp Asp 
        275                 280                 285             


Thr Leu Arg Leu Thr Gly Lys Arg Asp Asp Leu Asn Gly Leu Phe Tyr 
    290                 295                 300                 


Val Leu His Pro Gly Gly Arg Ala Ile Ile Asp Leu Leu Glu Glu Lys 
305                 310                 315                 320 


Leu Glu Leu Thr Lys Asp Lys Leu Glu Ser Ser Arg Arg Val Leu Ser 
                325                 330                 335     


Asn Tyr Gly Asn Met Trp Gly Pro Ala Leu Val Phe Thr Leu Asp Glu 
            340                 345                 350         


Met Arg Arg Lys Ser Lys Glu Asp Asn Ala Thr Thr Thr Gly Gly Gly 
        355                 360                 365             


Ser Glu Leu Gly Leu Met Met Ala Phe Gly Pro Gly Leu Thr Thr Glu 
    370                 375                 380                 


Ile Met Val Leu Arg Ser Val Pro Leu 
385                 390             


<210>  12
<211>  169
<212>  PRT
<213>  Streptomyces

<400>  12

Met Arg His Val Glu His Thr Val Thr Val Ala Ala Pro Ala Asp Leu 
1               5                   10                  15      


Val Trp Glu Val Leu Ala Asp Val Leu Gly Tyr Ala Asp Ile Phe Pro 
            20                  25                  30          


Pro Thr Glu Lys Val Glu Ile Leu Glu Glu Gly Gln Gly Tyr Gln Val 
        35                  40                  45              


Val Arg Leu His Val Asp Val Ala Gly Glu Ile Asn Thr Trp Thr Ser 
    50                  55                  60                  


Arg Arg Asp Leu Asp Pro Ala Arg Arg Val Ile Ala Tyr Arg Gln Leu 
65                  70                  75                  80  


Glu Thr Ala Pro Ile Val Gly His Met Ser Gly Glu Trp Arg Ala Phe 
                85                  90                  95      


Thr Leu Asp Ala Glu Arg Thr Gln Leu Val Leu Thr His Asp Phe Val 
            100                 105                 110         


Thr Arg Ala Ala Gly Asp Asp Gly Leu Val Ala Gly Lys Leu Thr Pro 
        115                 120                 125             


Asp Glu Ala Arg Glu Met Leu Glu Ala Val Val Glu Arg Asn Ser Val 
    130                 135                 140                 


Ala Asp Leu Asn Ala Val Leu Gly Glu Ala Glu Arg Arg Val Arg Ala 
145                 150                 155                 160 


Ala Gly Gly Val Gly Thr Val Thr Ala 
                165                 


<210>  13
<211>  256
<212>  PRT
<213>  Streptomyces

<400>  13

Met Ser Gly Arg Lys Thr Phe Leu Asp Leu Ser Phe Ala Thr Arg Asp 
1               5                   10                  15      


Thr Pro Ser Glu Ala Thr Pro Val Val Val Asp Leu Leu Asp His Val 
            20                  25                  30          


Thr Gly Ala Thr Val Leu Gly Leu Ser Pro Glu Asp Phe Pro Asp Gly 
        35                  40                  45              


Met Ala Ile Ser Asn Glu Thr Val Thr Leu Thr Thr His Thr Gly Thr 
    50                  55                  60                  


His Met Asp Ala Pro Leu His Tyr Gly Pro Leu Ser Gly Gly Val Pro 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Gln Val Pro Leu Glu Trp Cys Tyr Gly Pro Gly 
                85                  90                  95      


Val Arg Leu Asp Val Arg His Val Pro Ala Gly Asp Gly Ile Thr Val 
            100                 105                 110         


Asp His Leu Asn Ala Ala Leu Asp Ala Ala Glu His Asp Leu Ala Pro 
        115                 120                 125             


Gly Asp Ile Val Met Leu Trp Thr Gly Ala Asp Ala Leu Trp Gly Thr 
    130                 135                 140                 


Arg Glu Tyr Leu Ser Thr Phe Pro Gly Leu Thr Gly Lys Gly Thr Gln 
145                 150                 155                 160 


Phe Leu Val Glu Ala Gly Val Lys Val Ile Gly Ile Asp Ala Trp Gly 
                165                 170                 175     


Leu Asp Arg Pro Met Ala Ala Met Ile Glu Glu Tyr Arg Arg Thr Gly 
            180                 185                 190         


Asp Lys Gly Ala Leu Trp Pro Ala His Val Tyr Gly Arg Thr Arg Glu 
        195                 200                 205             


Tyr Leu Gln Leu Glu Lys Leu Asn Asn Leu Gly Ala Leu Pro Gly Ala 
    210                 215                 220                 


Thr Gly Tyr Asp Ile Ser Cys Phe Pro Val Ala Val Ala Gly Thr Gly 
225                 230                 235                 240 


Ala Gly Trp Thr Arg Val Val Ala Val Phe Glu Gln Glu Glu Glu Asp 
                245                 250                 255     


