                               SEQUENCE LISTING

<110> CAMBRIDGE EPIGENETIX LIMITED
 
<120> DETERMINATION OF EPIGENETIC MODIFICATIONS BY NANOPORE SEQUENCING

<130> 47224-729.602

<140> PCT/IB2019/000855
<141> 2019-06-14

<150> 62/685,217
<151> 2018-06-14

<160> 37    

<170> PatentIn version 3.5

<210> 1
<211> 2152
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
ttggatcact ataaatatgg gtgttatatt taataataat tgtgtattat gtataataag       60

aaaaatgtgt ttttgtattt aaagttatta tacaaatatg tctatatata tatatatata      120

tatatagata tatatatata tatagatata gataaaaata aatataaatg aaagaaccat      180

aagattaatt taatttttca ttgaatttta acatagttta ttttaatgat atagcaacaa      240

aaatatatat attaatgaag atataaatgc aaatataact tttgtataat tagaataaaa      300

aacgtataag aaaaaaaata taaagagaat tatttatatt aacaaataat tttaggaaaa      360

aaatatatat gtaattttgt aaaaactaaa aaagaaatat taaaacaaat aaacccaagc      420

aaaccaaatc aaacaaacaa acaagttata aaaaaatgaa taaaaaaatt ttaataataa      480

tataaaaaat atacaacatt tataatacaa cttttgtgta ataaaacata aacatatatt      540

attaaatata agaatttata attttataat ataaaattga atcatataaa gctatatata      600

tatatatata tatatattat ttaatatgat aattataatt ccttaaccat aatgtattat      660

atttacaaga atttatatta atgtattcat tagattatta tttggtagaa attacacaaa      720

cctatattac aaatttgttt aaacatatga ataagaatta ttagataaaa tataaaataa      780

tgattcaaat gatatatgtt attttgtttt tcataatata aagtttttta tgcaaagaaa      840

tatatatttc tataataata aaatgataca aattaaaata ttaagataca cttcattaca      900

aatcacacta atatgaattg tcttacatta atagaatgtg tattatataa aatattttaa      960

attattataa tgtatatatg tatatatata taatagaaga atgttattta tattttttgt     1020

atatagcctt ttttaaatta catattatat atatcaaaca tgtatttaaa tcacgactgg     1080

atacatttat cttatacata ttttataact ataatctttt ttttcctttt tttttctctt     1140

acatatatat tacaaactaa atatagaaat tacaaatata ttatattatt catccaaaaa     1200

catctaaaat aataaatttt tttttttttt ataatattta aattcaaata gaactattag     1260

tatattgaat agattatata ttttttttta acactttatt ttgaaaattt aaatcacgta     1320

cattattata tagaataata ttaggttttt catgtcaata tgatatatat atatatatat     1380

atataaatat tttatgaatt gatttataat gggtaataaa atataacttg tactatatgt     1440

ataaagttgt acagtttttc aaagttaaaa aaaatattaa tataaaaaaa aataataata     1500

aataaataaa taaataacat ttacaagtat acacctatta atatatatat atatatataa     1560

ttaaattata attataattt tttgcttatc acatttcata aatgaaaaaa aaaaaaaaaa     1620

tctattaaat actgttatat atttatctca tcacatttat gtgatttcta cttaatacac     1680

atattctata ttatttaaca taaaaaatat taaattaata tgttttattc cttataatat     1740

catattaaaa taaacatatt aatatgaatc ataattttaa atttctttta tttttttttt     1800

tttttagagg atataatttg ttcttcgtat tcattgtata tttcattata gttttgttca     1860

taatccttta aacaagaaaa attaaaattt cttatatcat cagttgaata tttattattt     1920

tttaattcat gaaattcttt ggtaaatttc atgtcattga ttcatgatac tcttccaaat     1980

tcattagcac aacacaaaca tattgatgta tagctcacat ccttgtcaac tttacaaatc     2040

ataaatttaa aatcaattga atcttgtgga aaacctttca taaattcatt taataaagca     2100

cttattcttt ctttattaac accacgtgta tgttcccaca aattaaaaag at             2152


<210> 2
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 2
agaaattaca caaacctata ttacaaattt gtttaaacat                             40


<210> 3
<211> 1533
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
atatgataat tattatatgc cattctttct ttttatattg agcattttta atactattat       60

attattatta tttatatata tatatatatt tattatatat atataatata attatataaa      120

aatatataac tttttaaaaa agaaaatctt ttaaatatac attttcttct ttataaattt      180

taatacatgt acttcttttt ttttttattt acataaaata atatatttat ttttatatat      240

cacatttatt acatgttttc ttttattttt tgaattatga aaatattata tatagaaaag      300

aaaaatatat ataatatgtt ataatgaata atatattata taaggatgta aggtcttctt      360

tctttttata tataatatcc aaaaacgatt tgtataataa aaagtgtata aaataattat      420

acgaaatatt ttataaatac aaaaaggtat attatatata tatatatata taatattata      480

gtattgtata cgtttatatt tttcttttcc ttcccataat aattatagca aaaaaaaaaa      540

aaaaaaaaga aagaaaaagg tatgctttat atatatgtat acattttaat acatatagcc      600

atttttaata tatcacaaaa taaataaatt aattaaaaca ttatttctat aaatatgttt      660

cattttggcg tcttttataa acgatataat tattatttaa taataaaagg aaaaaataat      720

aattaataaa ttttagtaat atataataat gtcatagtgg taatataata tattattata      780

tattattata tatttttaaa aaaagaaaaa ttataaaagg catcatttct tatatatcca      840

taattttata actaaaaaat gtgtatatat aaagtatatg ttaatatata tatatatata      900

tatatatata tatatacata taattattta tttattcatt catttatcta tctatcatca      960

tatttacaat ttaactacag tgtttcataa gtttgtccat gtgagcacat aataacattt     1020

gcaatatatt tcgttttcca cattttggct tttattttaa attaatattt attctttttg     1080

ttaactggta tatatacaat atatatatat atatatcttt tatggtatca tattaaacca     1140

ataaaaaaaa agagaaaaaa taaataaata aatatatata tatatatata tataataagt     1200

aatatccaaa ataaaaatta tatatcatat tcctataaaa ttcatcacac tcttttcaca     1260

ttttgtatta ttttatgtat atttagataa tacaatagga atttttcacg tatataacaa     1320

aaacaatata taatgataaa atgaaaatga tcagattaaa aaaaaaacat atatattata     1380

tatcataaca tttatatttt tctggcataa gtattactta agtacaattt taaattaaga     1440

atttctactt gtgaaatata ctattcgtta ttcttttcat tcttttactt tttttttgat     1500

tttttaaaag gtagccgtaa tttcatattt ata                                  1533


<210> 4
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
atacattttc ttctttataa attttaatac atgtacttct                             40


<210> 5
<211> 1533
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
atatgataat tattatatgc cattctttct ttttatattg agcattttta atactattat       60

attattatta tttatatata tatatatatt tattatatat atataatata attatataaa      120

aatatataac tttttaaaaa agaaaatctt ttaaatatac attttcttct ttataaattt      180

taatacatgt acttcttttt ttttttattt acataaaata atatatttat ttttatatat      240

cacatttatt acatgttttc ttttattttt tgaattatga aaatattata tatagaaaag      300

aaaaatatat ataatatgtt ataatgaata atatattata taaggatgta aggtcttctt      360

tctttttata tataatatcc aaaaacgatt tgtataataa aaagtgtata aaataattat      420

acgaaatatt ttataaatac aaaaaggtat attatatata tatatatata taatattata      480

gtattgtata cgtttatatt tttcttttcc ttcccataat aattatagca aaaaaaaaaa      540

aaaaaaaaga aagaaaaagg tatgctttat atatatgtat acattttaat acatatagcc      600

atttttaata tatcacaaaa taaataaatt aattaaaaca ttatttctat aaatatgttt      660

cattttggcg tcttttataa acgatataat tattatttaa taataaaagg aaaaaataat      720

aattaataaa ttttagtaat atataataat gtcatagtgg taatataata tattattata      780

tattattata tatttttaaa aaaagaaaaa ttataaaagg catcatttct tatatatcca      840

taattttata actaaaaaat gtgtatatat aaagtatatg ttaatatata tatatatata      900

tatatatata tatatacata taattattta tttattcatt catttatcta tctatcatca      960

tatttacaat ttaactacag tgtttcataa gtttgtccat gtgagcacat aataacattt     1020

gcaatatatt tcgttttcca cattttggct tttattttaa attaatattt attctttttg     1080

ttaactggta tatatacaat atatatatat atatatcttt tatggtatca tattaaacca     1140

ataaaaaaaa agagaaaaaa taaataaata aatatatata tatatatata tataataagt     1200

aatatccaaa ataaaaatta tatatcatat tcctataaaa ttcatcacac tcttttcaca     1260

ttttgtatta ttttatgtat atttagataa tacaatagga atttttcacg tatataacaa     1320

aaacaatata taatgataaa atgaaaatga tcagattaaa aaaaaaacat atatattata     1380

tatcataaca tttatatttt tctggcataa gtattactta agtacaattt taaattaaga     1440

atttctactt gtgaaatata ctattcgtta ttcttttcat tcttttactt tttttttgat     1500

tttttaaaag gtagccgtaa tttcatattt ata                                  1533


<210> 6
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 6
atatatcaca tttattacat gttttctttt a                                      31


<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
ttggatcact ataaatatgg gtgt                                              24


<210> 8
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
tttttaaatt acatattata tatat                                             25


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
ttttaaatta catattatat a                                                 21


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ttttaaatta catattatat a                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
ttttaaatta catattatat a                                                 21


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
ttttaaatta catattatat a                                                 21


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
ttttaaatta catattatat a                                                 21


<210> 14
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
tttataaatt ttaatacatg tacttctt                                          28


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
aattttaata catgtacttc t                                                 21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
aattttaata catgtacttc t                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
aattttaata catgtacttc t                                                 21


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
aattttaata catgtacttc t                                                 21


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
aattttaata catgtacttc t                                                 21


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
aattttaata catgtacttc t                                                 21


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
aattttaata catgtacttc t                                                 21


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
aattttaata catgtacttc t                                                 21


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
aattttaata catgtacttc t                                                 21


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
aattttaata catgtacttc t                                                 21


<210> 25
<211> 1028
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
aaaaagaaaa taaaacaaag gaaagtaaag caaatgaaat taaatcaaac gaaactaaac       60

caagagaaga taagacaagg gaaggtaagg caagtgaagt taagtcaagc gaagctaagc      120

caatagaata taatacaatg gaatgtaatg caattgaatt taattcaatc gaatctaatc      180

caacagaaca taacacaacg gaacgtaacg caactgaact taactcaacc gaacctaacc      240

cagaggagag tagagcagat gagattagat cagacgagac tagaccagga taggacaggg      300

gagggtaggg caggtgaggt taggtcaggc gaggctaggc cagtatagta cagtggagtg      360

tagtgcagtt gagtttagtt cagtcgagtc tagtccagca tagcacagcg gagcgtagcg      420

cagctgagct tagctcagcc gagcctagcc catatgatat tatatcatac gatactatac      480

catgacatgg gatggtatgg catgtgatgt tatgtcatgc gatgctatgc cattacattg      540

gattgtattg catttgattt tatttcattc gattctattc catcacatcg gatcgtatcg      600

catctgatct tatctcatcc gatcctatcc cacacgacac tacaccacgg gacggtacgg      660

cacgtgacgt tacgtcacgc gacgctacgc cactggactg tactgcactt gactttactt      720

cactcgactc tactccaccg gaccgtaccg cacctgacct tacctcaccc gaccctaccc      780

cgggggtggg gcgggttggg tcgggctggg ccggtgtggt gcggtttggt tcggtctggt      840

ccggcgtggc gcggcttggc tcggcctggc ccgtgttgtg tcgtgctgtg ccgttgcgtt      900

ttgtttcgtt ctgttccgtc gcgtcttgtc tcgtcctgtc ccgcgctgcg ccgctttgct      960

tcgctctgct ccgccttgcc tcgccctgcc cctttttctt tccttctctt ccctctcctc     1020

ccccaaaa                                                              1028


<210> 26
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
tactatacca tgacatggga tggtatggca tgtgatgtta tgtcatgcga                  50


<210> 27
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
tactatacca tgacatggga tggtatggca tgtgatgtta tgtcatgcga                  50


<210> 28
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (10)..(10)
<223> Abasic nucleotide

<400> 28
aaaccttccn acaacgaggc ctacgatccc gacgaat                                37


<210> 29
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (10)..(10)
<223> Abasic nucleotide

<400> 29
aaaccttccn acaacgaggc ctacgatccc gacgaat                                37


<210> 30
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
tactatacca tgacatggga tggtatggca tgtgatgtta tgtcatgcga                  50


<210> 31
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
tactatacca tgacatggga tggtatggca tgtgatgtta tgtcatgcga                  50


<210> 32
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
tccaacagaa cata                                                         14


<210> 33
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
tccaacagaa cata                                                         14


<210> 34
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
ccaacagaac ataac                                                        15


<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 36
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
actaaactaa ataaatt                                                      17


<210> 37
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
ttactttact tacttc                                                       16


