                         SEQUENCE LISTING

<110>  Berlin-Chemie AG
 
<120>  Pharmaceutical combinations

<130>  489.138735/02

<160>  203   

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Human

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ile Phe Gly Val Val Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  108
<212>  PRT
<213>  Human

<400>  2

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  3
<211>  357
<212>  DNA
<213>  Human

<400>  3
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc cgggggggtc ccttagactc       60

tcctgtgcag cctctggctt cacttacagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca      180

gactacgctg cacccgtgca aggcagattc accatctcaa gagatgattc aaaaaacacg      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtacgatt      300

tttggagtgg ttagctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  4
<211>  324
<212>  DNA
<213>  Human

<400>  4
gacgtccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc gactatttaa gttggtatca gcagagacca      120

gggaaagccc ctaacctcct gatctatgct gcatccaatt taaagactgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcac tctgcaacct      240

gaagattttg caacgtacta ctgtcaacag agttacaggt ccccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acga                                             324


<210>  5
<211>  5
<212>  PRT
<213>  Human

<400>  5

Asn Ala Trp Met Ser 
1               5   


<210>  6
<211>  19
<212>  PRT
<213>  Human

<400>  6

Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Gln Gly 
            


<210>  7
<211>  8
<212>  PRT
<213>  Human

<400>  7

Phe Gly Val Val Ser Phe Asp Tyr 
1               5               


<210>  8
<211>  11
<212>  PRT
<213>  Human

<400>  8

Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu Ser 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Human

<400>  9

Ala Ala Ser Asn Leu Lys Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Human

<400>  10

Gln Gln Ser Tyr Arg Ser Pro Trp Thr 
1               5                   


<210>  11
<211>  104
<212>  PRT
<213>  Human

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Thr Thr Val Thr 
            100                 


<210>  12
<211>  15
<212>  PRT
<213>  Human

<400>  12

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  13
<211>  93
<212>  PRT
<213>  Human

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
                85                  90              


<210>  14
<211>  13
<212>  PRT
<213>  Human

<400>  14

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10              


<210>  15
<211>  1722
<212>  PRT
<213>  Human

<400>  15

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  16
<211>  30
<212>  PRT
<213>  Human

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser 
            20                  25                  30  


<210>  17
<211>  14
<212>  PRT
<213>  Human

<400>  17

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  18
<211>  32
<212>  PRT
<213>  Human

<400>  18

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
            20                  25                  30          


<210>  19
<211>  11
<212>  PRT
<213>  Human

<400>  19

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  20
<211>  23
<212>  PRT
<213>  Human

<400>  20

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  21
<211>  15
<212>  PRT
<213>  Human

<400>  21

Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  22
<211>  32
<212>  PRT
<213>  Human

<400>  22

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Thr Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  23
<211>  11
<212>  PRT
<213>  Human

<400>  23

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  24
<211>  10
<212>  PRT
<213>  Human

<400>  24

Trp Glu Val Lys Asp Cys Arg Ser Phe Lys 
1               5                   10  


<210>  25
<211>  12
<212>  PRT
<213>  Human

<400>  25

Pro Ala Ser Leu Ser Cys Tyr Lys Val Phe His Ala 
1               5                   10          


<210>  26
<211>  20
<212>  PRT
<213>  Human

<400>  26

Pro Trp Arg Arg Gly Trp His Phe Tyr Asp Asp Arg Glu Phe Ile Tyr 
1               5                   10                  15      


Leu Arg Pro Phe 
            20  


<210>  27
<211>  19
<212>  PRT
<213>  Human

<400>  27

Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe Pro Val 
1               5                   10                  15      


Thr Phe Gly 
            


<210>  28
<211>  12
<212>  PRT
<213>  Human

<400>  28

Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu 
1               5                   10          


<210>  29
<211>  17
<212>  PRT
<213>  Human

<400>  29

Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln Lys Tyr 
1               5                   10                  15      


Ser 
    


<210>  30
<211>  12
<212>  PRT
<213>  Human

<400>  30

Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile 
1               5                   10          


<210>  31
<211>  11
<212>  PRT
<213>  Human

<400>  31

Glu Ala Val Tyr Phe His Gln His Ser Ile Leu 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Human

<400>  32

Lys Lys Leu Ser Arg Leu Thr Tyr Ser Ser Cys 
1               5                   10      


<210>  33
<211>  20
<212>  PRT
<213>  Human

<400>  33

Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp 
1               5                   10                  15      


Gln Ala Leu His 
            20  


<210>  34
<211>  25
<212>  PRT
<213>  Human

<400>  34

Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro 
1               5                   10                  15      


Trp His Arg Phe Pro Val Thr Phe Gly 
            20                  25  


<210>  35
<211>  20
<212>  PRT
<213>  Human

<400>  35

Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu 
1               5                   10                  15      


Tyr Lys Ile Ile 
            20  


<210>  36
<211>  10
<212>  PRT
<213>  Human

<400>  36

Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro 
1               5                   10  


<210>  37
<211>  15
<212>  PRT
<213>  Human

<400>  37

Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln Lys 
1               5                   10                  15  


<210>  38
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain A1

<400>  38

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr 
        35                  40                  45              


Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp 
65                  70                  75                  80  


Tyr Ala Ala Pro Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Ile Phe Gly Val Val Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  39
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain A1

<400>  39

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asp Tyr Leu Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro 
    50                  55                  60                  


Asn Leu Leu Ile Tyr Ala Ala Ser Asn Leu Lys Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Thr Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Arg Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Trp His Phe Tyr Asp Asp Arg 
1               5               


<210>  41
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  41

Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg 
1               5                   10                  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Phe Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu Val Ser Gly Arg 
1               5                   10                  15  


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

His Phe Val Ser Leu Cys Gln Lys 
1               5               


<210>  45
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys 
1               5                   10      


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Gly Phe Leu Gly 
1               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  47

Trp Glu Val Lys Asp Cys Arg Ser 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  48

Glu Val Lys Asp Cys Arg Ser Phe 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  49

Val Lys Asp Cys Arg Ser Phe Lys 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  50

Lys Asp Cys Arg Ser Phe Lys Ala 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  51

Asp Cys Arg Ser Phe Lys Ala Leu 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  52

Cys Arg Ser Phe Lys Ala Leu Ser 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  53

Arg Ser Phe Lys Ala Leu Ser Ile 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  54

Pro Ala Ser Leu Ser Cys Tyr Lys 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  55

Ala Ser Leu Ser Cys Tyr Lys Val 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  56

Ser Leu Ser Cys Tyr Lys Val Phe 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  57

Leu Ser Cys Tyr Lys Val Phe His 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  58

Ser Cys Tyr Lys Val Phe His Ala 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  59

Cys Tyr Lys Val Phe His Ala Glu 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  60

Tyr Lys Val Phe His Ala Glu Arg 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  61

Lys Val Phe His Ala Glu Arg Ile 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  62

Val Phe His Ala Glu Arg Ile Val 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  63

Phe His Ala Glu Arg Ile Val Arg 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  64

Asp Cys Ala Ala Val Lys Val Phe 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  65

Ala Ala Val Lys Val Phe His Arg 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  66

Val Lys Val Phe His Arg Pro Trp 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  67

Val Phe His Arg Pro Trp Arg Arg 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  68

His Arg Pro Trp Arg Arg Gly Trp 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  69

Pro Trp Arg Arg Gly Trp His Phe 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  70

Arg Arg Gly Trp His Phe Tyr Asp 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  71

Gly Trp His Phe Tyr Asp Asp Arg 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  72

His Phe Tyr Asp Asp Arg Glu Phe 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  73

Tyr Asp Asp Arg Glu Phe Ile Tyr 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  74

Asp Arg Glu Phe Ile Tyr Leu Arg 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  75

Glu Phe Ile Tyr Leu Arg Pro Phe 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  76

Pro Ile Asp Asp His Phe Thr Tyr 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  77

Ile Asp Asp His Phe Thr Tyr Ser 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  78

Asp Asp His Phe Thr Tyr Ser Arg 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  79

Asp His Phe Thr Tyr Ser Arg Tyr 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  80

His Phe Thr Tyr Ser Arg Tyr Pro 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  81

Phe Thr Tyr Ser Arg Tyr Pro Trp 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  82

Thr Tyr Ser Arg Tyr Pro Trp His 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  83

Tyr Ser Arg Tyr Pro Trp His Arg 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  84

Ser Arg Tyr Pro Trp His Arg Phe 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  85

Arg Tyr Pro Trp His Arg Phe Pro 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  86

Tyr Pro Trp His Arg Phe Pro Val 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  87

Pro Trp His Arg Phe Pro Val Thr 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  88

Trp His Arg Phe Pro Val Thr Phe 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  89

His Arg Phe Pro Val Thr Phe Gly 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  90

Arg Glu Leu Thr Tyr Ser Asn Phe 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  91

Glu Leu Thr Tyr Ser Asn Phe His 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  92

Leu Thr Tyr Ser Asn Phe His Pro 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  93

Thr Tyr Ser Asn Phe His Pro Leu 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  94

Tyr Ser Asn Phe His Pro Leu Leu 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  95

Ser Asn Phe His Pro Leu Leu Val 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  96

Asn Phe His Pro Leu Leu Val Ser 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  97

Phe His Pro Leu Leu Val Ser Gly 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  98

His Pro Leu Leu Val Ser Gly Arg 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  99

Pro Leu Leu Val Ser Gly Arg Leu 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  100

Leu Leu Val Ser Gly Arg Leu Arg 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  101

Leu Val Ser Gly Arg Leu Arg Ile 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  102

Val Ser Gly Arg Leu Arg Ile Pro 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  103

Phe Thr Ser Cys Ser Glu Arg His 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  104

Thr Ser Cys Ser Glu Arg His Phe 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  105

Ser Cys Ser Glu Arg His Phe Val 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  106

Cys Ser Glu Arg His Phe Val Ser 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  107

Ser Glu Arg His Phe Val Ser Leu 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  108

Glu Arg His Phe Val Ser Leu Cys 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  109

Arg His Phe Val Ser Leu Cys Gln 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  110

His Phe Val Ser Leu Cys Gln Lys 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  111

Phe Val Ser Leu Cys Gln Lys Tyr 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  112

Val Ser Leu Cys Gln Lys Tyr Ser 
1               5               


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  113

Ser Leu Cys Gln Lys Tyr Ser Glu 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  114

Leu Cys Gln Lys Tyr Ser Glu Val 
1               5               


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  115

Cys Gln Lys Tyr Ser Glu Val Lys 
1               5               


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  116

Gln Lys Tyr Ser Glu Val Lys Ser 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  117

Thr Val Lys Tyr Leu Asn Asn Leu 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  118

Val Lys Tyr Leu Asn Asn Leu Tyr 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  119

Lys Tyr Leu Asn Asn Leu Tyr Lys 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  120

Tyr Leu Asn Asn Leu Tyr Lys Ile 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  121

Leu Asn Asn Leu Tyr Lys Ile Ile 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  122

Asn Asn Leu Tyr Lys Ile Ile Pro 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  123

Asn Leu Tyr Lys Ile Ile Pro Lys 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  124

Leu Tyr Lys Ile Ile Pro Lys Thr 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  125

Tyr Lys Ile Ile Pro Lys Thr Leu 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  126

Lys Ile Ile Pro Lys Thr Leu Thr 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  127

Ile Ile Pro Lys Thr Leu Thr Trp 
1               5               


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  128

Ile Pro Lys Thr Leu Thr Trp His 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  129

Pro Lys Thr Leu Thr Trp His Ser 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  130

Lys Thr Leu Thr Trp His Ser Ala 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  131

Thr Leu Thr Trp His Ser Ala Lys 
1               5               


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  132

Glu Ala Val Tyr Phe His Gln His 
1               5               


<210>  133
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  133

Ala Val Tyr Phe His Gln His Ser 
1               5               


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  134

Val Tyr Phe His Gln His Ser Ile 
1               5               


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  135

Tyr Phe His Gln His Ser Ile Leu 
1               5               


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  136

Phe His Gln His Ser Ile Leu Ala 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  137

Lys Lys Leu Ser Arg Leu Thr Tyr 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  138

Lys Leu Ser Arg Leu Thr Tyr Ser 
1               5               


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  139

Leu Ser Arg Leu Thr Tyr Ser Ser 
1               5               


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  140

Ser Arg Leu Thr Tyr Ser Ser Arg 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  141

Arg Leu Thr Tyr Ser Ser Arg Cys 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  142

Asn Gly Ser Arg Trp Ile Gln Tyr 
1               5               


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  143

Gly Ser Arg Trp Ile Gln Tyr Lys 
1               5               


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  144

Ser Arg Trp Ile Gln Tyr Lys Gly 
1               5               


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  145

Arg Trp Ile Gln Tyr Lys Gly His 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  146

Trp Ile Gln Tyr Lys Gly His Cys 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  147

Ile Gln Tyr Lys Gly His Cys Tyr 
1               5               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  148

Gln Tyr Lys Gly His Cys Tyr Lys 
1               5               


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  149

Tyr Lys Gly His Cys Tyr Lys Ser 
1               5               


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  150

Lys Gly His Cys Tyr Lys Ser Asp 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  151

Gly His Cys Tyr Lys Ser Asp Gln 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  152

His Cys Tyr Lys Ser Asp Gln Ala 
1               5               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  153

Cys Tyr Lys Ser Asp Gln Ala Leu 
1               5               


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  154

Tyr Lys Ser Asp Gln Ala Leu His 
1               5               


<210>  155
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  155

Lys Ser Asp Gln Ala Leu His Ser 
1               5               


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  156

Ser Asp Gln Ala Leu His Ser Phe 
1               5               


<210>  157
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  157

Asp Gln Ala Leu His Ser Phe Ser 
1               5               


<210>  158
<211>  1722
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  159
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  159

Cys Ile Lys Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu 
1               5                   10                  15      


Thr Glu Asp Lys Leu Trp Lys 
            20              


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  160

Cys Glu His His Ser Leu Tyr Gly Ala Ala Arg 
1               5                   10      


<210>  161
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  161

Asp Gly His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys 
1               5                   10                  15      


Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr 
            20                  25                  30          


Thr Arg 
        


<210>  162
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  162

Lys Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile 
1               5                   10                  15      


Tyr Thr Arg 
            


<210>  163
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  163

Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr 
1               5                   10                  15      


Thr Arg 
        


<210>  164
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  164

Asp Gly His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys 
1               5                   10                  15  


<210>  165
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  165

Trp Gly Ile Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu 
1               5                   10                  15      


Lys 
    


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  166

Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg 
1               5                   10              


<210>  167
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  167

Leu His Asn Glu Asp Ile Lys Glu Glu Val Trp Ile Gly Leu Lys 
1               5                   10                  15  


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  168

Thr Pro Asn Cys Val Ser Tyr Leu Gly Glu Leu Gly Gln Trp Lys 
1               5                   10                  15  


<210>  169
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  169

Tyr Phe Trp Thr Gly Leu Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn 
1               5                   10                  15      


Trp Ala Thr Val Gly Gly Arg 
            20              


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  170

Ser Val Gly Lys Trp Glu Val Lys Asp Cys Arg 
1               5                   10      


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  171

Trp Glu Val Lys Asp Cys Arg Ser Phe Lys 
1               5                   10  


<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  172

Ala Leu Ser Ile Cys Lys Lys 
1               5           


<210>  173
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  173

Pro Ala Ser Leu Ser Cys Tyr Lys Val Phe His Ala 
1               5                   10          


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  174

Arg Asn Trp Glu Glu Ala Glu Arg 
1               5               


<210>  175
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  175

Arg Ser Pro Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro 
1               5                   10                  15      


Val Ser Thr Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile 
            20                  25                  30          


Arg 
    


<210>  176
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  176

Thr Pro Val Ser Thr Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr 
1               5                   10                  15      


Asp Ile Arg 
            


<210>  177
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  177

Pro Trp Arg Arg Gly Trp His Phe Tyr Asp Asp Arg Glu Phe Ile Tyr 
1               5                   10                  15      


Leu Arg Pro Phe 
            20  


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  178

Gly Trp His Phe Tyr Asp Asp Arg 
1               5               


<210>  179
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  179

Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg 
1               5                   10                  


<210>  180
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  180

Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe Pro Val 
1               5                   10                  15      


Thr Phe Gly 
            


<210>  181
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  181

Phe Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr 
1               5                   10                  15      


Trp Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys 
            20                  25                  30  


<210>  182
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  182

Thr Trp Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys 
1               5                   10                  15  


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  183

Tyr Asn Val Ser Ser Leu Glu Lys 
1               5               


<210>  184
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  184

Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
1               5                   10          


<210>  185
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  185

Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu 
1               5                   10          


<210>  186
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  186

Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu Val Ser Gly Arg Leu 
1               5                   10                  15      


Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser Arg Tyr His Cys Ala 
            20                  25                  30          


Leu Ile Leu Asn Leu Gln Lys 
        35                  


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  187

Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys 
1               5                   10      


<210>  188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  188

Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln Lys Tyr 
1               5                   10                  15      


Ser 
    


<210>  189
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  189

His Phe Val Ser Leu Cys Gln Lys 
1               5               


<210>  190
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  190

Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys 
1               5                   10      


<210>  191
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  191

Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile 
1               5                   10          


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  192

Thr Leu Thr Trp His Ser Ala Lys 
1               5               


<210>  193
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  193

Asn Arg His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys 
1               5                   10                  


<210>  194
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  194

Ser His Ile Leu Ser Ile Arg 
1               5           


<210>  195
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  195

Ser Leu Met Trp Phe Asp Lys Thr Pro Leu Ser Tyr Thr His Trp Arg 
1               5                   10                  15      


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  196

Ser Leu Met Trp Phe Asp Lys 
1               5           


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  197

Glu Ala Val Tyr Phe His Gln His Ser Ile Leu 
1               5                   10      


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  198

Lys Lys Leu Ser Arg Leu Thr Tyr Ser Ser 
1               5                   10  


<210>  199
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  199

Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp 
1               5                   10                  15      


Gln Ala Leu His 
            20  


<210>  200
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  200

His Asp His Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn 
1               5                   10                  15      


Lys Phe Val Ser Arg 
            20      


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  201

Val Glu Cys Glu His Gly Phe Gly Arg 
1               5                   


<210>  202
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  202
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgaa       60

gttcagctgg tcgaaagcgg aggaggtctg gtgaaacccg gtggctccct gaggctgagc      120

tgcgccgcct ccggctttac ttacagtaat gcctggatgt cctgggtcag acaggcccca      180

ggtaagggtc tggagtgggt gggtaggatt aagtctaaaa ctgatggcgg gacaacagac      240

tatgccgccc cagtgcaagg acggttcacc atttctaggg acgactctaa gaatacactg      300

tatctgcaga tgaacagcct caaaacagaa gacactgccg tttactactg taccatcttt      360

ggcgttgtct cctttgatta ttggggacag ggtacactcg tgaccgtttc ttccgcaagt      420

acaaaggggc catcagtgtt tccactggcc ccatcctcta agagcactag tggcggcaca      480

gccgccctgg gatgtctggt gaaggactat ttcccagagc ctgtgaccgt cagctggaac      540

agtggtgctc tcacctcagg tgtgcacaca ttccccgctg tgctccaatc cagtggcctc      600

tacagtctga gcagcgttgt gactgttccc agtagctcac tgggcaccca aacctacata      660

tgcaatgtga accataaacc tagcaatacc aaagtggaca agaaagtgga acctaagtcc      720

tgtgacaaga ctcatacctg tcctccttgt cctgccccag agctgctcgg aggcccttcc      780

gtctttctct tcccaccaaa gccaaaggat accctgatga tcagccggac acctgaggtt      840

acctgcgttg tggtcgacgt ttcacacgag gatcctgaag tcaaattcaa ctggtacgtt      900

gatggagtcg aggtccacaa cgccaaaacc aagcctcgcg aagaacaata caatagcaca      960

tatagggtgg tgtctgtgct cactgtcctg caccaggact ggctgaacgg caaggagtac     1020

aaatgcaagg ttagtaacaa ggccctgccc gcacccattg agaagactat cagtaaagct     1080

aagggccagc ctcgcgagcc tcaggtttac accctgcctc cctctagaga ggaaatgaca     1140

aagaaccagg tgtctctcac ctgcctggtt aaaggattct atccatccga cattgctgtg     1200

gaatgggaat ccaacggaca gcccgaaaac aactataaga caacaccacc tgttctggat     1260

tccgatggtt ccttctttct gtattccaaa ctcacagtgg acaagagtcg ctggcagcaa     1320

ggtaacgtgt tttcttgctc cgtgatgcac gaagcactcc acaatcacta cactcagaag     1380

agtctcagcc tctctccagg caaa                                            1404


<210>  203
<211>  702
<212>  DNA
<213>  homo sapiens

<400>  203
atgtctgtgc ctacccaggt gctgggactg ctgctgctgt ggctgacaga cgcccgctgt       60

gatgttcaga tgacacagtc tccaagtagt ctcagcgcaa gcgttggcga cagagtgact      120

atcacatgca gagcctctca gtctatctct gactatctgt cttggtacca gcagaggcca      180

ggcaaagctc caaacctcct gatctatgct gccagtaatc tgaagacagg cgtgcctagt      240

agattctccg ggtccggtag tgggactgat ttcaccctga caatctccac actgcaacct      300

gaggattttg ctacctacta ttgtcagcaa tcttatcgca gcccttggac cttcggacag      360

gggactaagg ttgagattaa acgcaccgtg gcagcaccca gcgtctttat ctttcctccc      420

tccgacgagc agctcaagtc cggaacagca tcagtcgttt gcctcctgaa taacttttat      480

ccaagggagg ccaaggtcca gtggaaagtc gacaatgccc tccaatctgg taactcccag      540

gagtctgtga ctgaacaaga ttctaaggac agtacctatt cactcagctc caccctgacc      600

ctcagcaaag cagactacga aaagcataaa gtttacgctt gcgaagtgac ccaccaaggc      660

ctgtcttctc ctgtcacaaa gagttttaat agaggggagt gt                         702


