                         SEQUENCE LISTING

<110>  Max-Planck-Gesellschaft zur Frderung der Wissenschaften 
       e.V.
 
<120>  Selection System For Evolving Proteases and Protease-Cleavage 
       Sites

<130>  30A-146 928

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  DegronNER

<400>  1

Phe Leu Phe Val Gln 
1               5   


<210>  2
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  ssrA

<400>  2

Ala Ala Asp Glu Asn Tyr Ala Leu Ala Ala 
1               5                   10  


<210>  3
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Wt bdSUMO

<400>  3

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Thr Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Asp Gly Arg Arg Leu Arg Ala Glu Gln Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  4
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  scSUMO/Smt3p

<400>  4

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly 
        


<210>  5
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  hsSUMO2

<400>  5

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly 
                85                  90              


<210>  6
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  bdSENP1

<400>  6

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Asn Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Arg Trp Thr Thr Lys Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  7
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  scUlp1

<400>  7

Leu Val Pro Glu Leu Asn Glu Lys Asp Asp Asp Gln Val Gln Lys Ala 
1               5                   10                  15      


Leu Ala Ser Arg Glu Asn Thr Gln Leu Met Asn Arg Asp Asn Ile Glu 
            20                  25                  30          


Ile Thr Val Arg Asp Phe Lys Thr Leu Ala Pro Arg Arg Trp Leu Asn 
        35                  40                  45              


Asp Thr Ile Ile Glu Phe Phe Met Lys Tyr Ile Glu Lys Ser Thr Pro 
    50                  55                  60                  


Asn Thr Val Ala Phe Asn Ser Phe Phe Tyr Thr Asn Leu Ser Glu Arg 
65                  70                  75                  80  


Gly Tyr Gln Gly Val Arg Arg Trp Met Lys Arg Lys Lys Thr Gln Ile 
                85                  90                  95      


Asp Lys Leu Asp Lys Ile Phe Thr Pro Ile Asn Leu Asn Gln Ser His 
            100                 105                 110         


Trp Ala Leu Gly Ile Ile Asp Leu Lys Lys Lys Thr Ile Gly Tyr Val 
        115                 120                 125             


Asp Ser Leu Ser Asn Gly Pro Asn Ala Met Ser Phe Ala Ile Leu Thr 
    130                 135                 140                 


Asp Leu Gln Lys Tyr Val Met Glu Glu Ser Lys His Thr Ile Gly Glu 
145                 150                 155                 160 


Asp Phe Asp Leu Ile His Leu Asp Cys Pro Gln Gln Pro Asn Gly Tyr 
                165                 170                 175     


Asp Cys Gly Ile Tyr Val Cys Met Asn Thr Leu Tyr Gly Ser Ala Asp 
            180                 185                 190         


Ala Pro Leu Asp Phe Asp Tyr Lys Asp Ala Ile Arg Met Arg Arg Phe 
        195                 200                 205             


Ile Ala His Leu Ile Leu Thr Asp Ala Leu Lys 
    210                 215                 


<210>  8
<211>  226
<212>  PRT
<213>  Artificial

<220>
<223>  hsSENP2

<400>  8

Glu Phe Pro Glu Ile Thr Glu Glu Met Glu Lys Glu Ile Lys Asn Val 
1               5                   10                  15      


Phe Arg Asn Gly Asn Gln Asp Glu Val Leu Ser Glu Ala Phe Arg Leu 
            20                  25                  30          


Thr Ile Thr Arg Lys Asp Ile Gln Thr Leu Asn His Leu Asn Trp Leu 
        35                  40                  45              


Asn Asp Glu Ile Ile Asn Phe Tyr Met Asn Met Leu Met Glu Arg Ser 
    50                  55                  60                  


Lys Glu Lys Gly Leu Pro Ser Val His Ala Phe Asn Thr Phe Phe Phe 
65                  70                  75                  80  


Thr Lys Leu Lys Thr Ala Gly Tyr Gln Ala Val Lys Arg Trp Thr Lys 
                85                  90                  95      


Lys Val Asp Val Phe Ser Val Asp Ile Leu Leu Val Pro Ile His Leu 
            100                 105                 110         


Gly Val His Trp Cys Leu Ala Val Val Asp Phe Arg Lys Lys Asn Ile 
        115                 120                 125             


Thr Tyr Tyr Asp Ser Met Gly Gly Ile Asn Asn Glu Ala Cys Arg Ile 
    130                 135                 140                 


Leu Leu Gln Tyr Leu Lys Gln Glu Ser Ile Asp Lys Lys Arg Lys Glu 
145                 150                 155                 160 


Phe Asp Thr Asn Gly Trp Gln Leu Phe Ser Lys Lys Ser Gln Glu Ile 
                165                 170                 175     


Pro Gln Gln Met Asn Gly Ser Asp Cys Gly Met Phe Ala Cys Lys Tyr 
            180                 185                 190         


Ala Asp Cys Ile Thr Lys Asp Arg Pro Ile Asn Phe Thr Gln Gln His 
        195                 200                 205             


Met Pro Tyr Phe Arg Lys Arg Met Val Trp Glu Ile Leu His Arg Lys 
    210                 215                 220                 


Leu Leu 
225     


<210>  9
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Wt bdSUMO; amino acids 56-79

<400>  9

Ser Val Asp Met Thr Ala Ile Ala Phe Leu Phe Asp Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Gln Thr Pro Asp Glu 
            20                  


<210>  10
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut1 bdSUMO

<400>  10

Ser Val Asp Met Lys Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Arg Thr Pro Asp Glu 
            20                  


<210>  11
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut2 bdSUMO

<400>  11

Ser Val Asp Met Thr Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Cys Thr Pro Asp Glu 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut3 bdSUMO

<400>  12

Ser Val Asp Met His Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Lys Thr Pro Asp Glu 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut4 bdSUMO

<400>  13

Ser Val Asp Met Arg Ala Ile Ala Phe Leu Phe Arg Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Val Thr Pro Asp Glu 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut5 bdSUMO

<400>  14

Ser Val Asp Met Thr Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Phe Thr Pro Asp Glu 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut6 bdSUMO

<400>  15

Ser Val Asp Met His Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Gln Thr Pro Asp Glu 
            20                  


<210>  16
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut7 bdSUMO

<400>  16

Ser Val Asp Met Asp Ala Ile Ala Phe Leu Phe Arg Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Cys Thr Pro Asp Glu 
            20                  


<210>  17
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut8 bdSUMO

<400>  17

Ser Val Asp Met Pro Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Trp Thr Pro Asp Glu 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut9 bdSUMO

<400>  18

Ser Val Asp Met Ala Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Tyr Thr Pro Asp Glu 
            20                  


<210>  19
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut10 bdSUMO

<400>  19

Ser Val Asp Met Thr Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Arg Thr Pro Asp Glu 
            20                  


<210>  20
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut11 bdSUMO

<400>  20

Ser Val Asp Met Ser Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Trp Thr Pro Asp Glu 
            20                  


<210>  21
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut12 bdSUMO

<400>  21

Ser Val Asp Met Ser Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu His Thr Pro Asp Glu 
            20                  


<210>  22
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut13 bdSUMO

<400>  22

Ser Val Asp Met Ser Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Ala Thr Pro Asp Glu 
            20                  


<210>  23
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut14 bdSUMO

<400>  23

Ser Val Asp Met Asn Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Trp Thr Pro Asp Glu 
            20                  


<210>  24
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Mut15 bdSUMO

<400>  24

Ser Val Asp Met Asn Ala Ile Ala Phe Leu Phe Lys Gly Arg Arg Leu 
1               5                   10                  15      


Arg Ala Glu Ala Thr Pro Asp Glu 
            20                  


<210>  25
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  Wt bdSENP1

<400>  25

Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser Asn 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Arg Trp Thr Thr Lys Arg Lys Leu Gly 
                85                  90  


<210>  26
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutA bdSENP1

<400>  26

Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser Gly 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Glu Trp Thr Thr Pro Arg Lys Leu Gly 
                85                  90  


<210>  27
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutB bdSENP1

<400>  27

Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser Ser 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Glu Trp Thr Thr Lys Arg Lys Leu Gly 
                85                  90  


<210>  28
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutC bdSENP1

<400>  28

Gly Gly Arg Lys Ser Ser Glu Thr Leu Ser Val His Glu Ala Ser Ala 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Gly Trp Thr Thr Val Arg Lys Leu Gly 
                85                  90  


<210>  29
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutD bdSENP1

<400>  29

Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser Glu 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Glu Trp Thr Thr Gln Arg Lys Leu Gly 
                85                  90  


<210>  30
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutE bdSENP1

<400>  30

Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser Gly 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Tyr Trp Thr Thr Ala Arg Lys Leu Gly 
                85                  90  


<210>  31
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutF bdSENP1

<400>  31

Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser Cys 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Leu Trp Thr Thr Arg Arg Lys Leu Gly 
                85                  90  


<210>  32
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  MutG bdSENP1

<400>  32

Gly Gly Arg Lys Ser Ser Glu Thr Leu Ser Val His Glu Ala Ser His 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Arg Trp Thr Thr Val Lys Leu Gly 
                85                  


<210>  33
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  MutH bdSENP1

<400>  33

Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser Ala 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Tyr Asp Tyr Lys Ser Val Arg 
65                  70                  75                  80  


Glu Trp Thr Thr Met Arg Lys Leu Gly 
                85                  


<210>  34
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  Muti bdSENP1

<400>  34

Gly Gly Arg Lys Lys Ser Glu Thr Leu Ser Val His Glu Ala Ser His 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Glu Trp Thr Thr Arg Arg Lys Leu Gly 
                85                  90  


<210>  35
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutJ bdSENP1

<400>  35

Gly Gly Arg Lys Glu Ser Glu Thr Leu Ser Val His Glu Ala Ser Ser 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Ser Trp Thr Thr Thr Arg Lys Leu Gly 
                85                  90  


<210>  36
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutK bdSENP1

<400>  36

Gly Gly Arg Lys Val Ser Glu Thr Leu Ser Val His Glu Ala Ser Gln 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Val Trp Thr Thr Gly Arg Lys Leu Gly 
                85                  90  


<210>  37
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutL bdSENP1

<400>  37

Gly Gly Arg Lys Leu Ser Glu Thr Leu Ser Val His Glu Ala Ser Val 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Pro Trp Thr Thr Ala Arg Lys Leu Gly 
                85                  90  


<210>  38
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutM bdSENP1

<400>  38

Gly Gly Arg Lys Ala Ser Glu Thr Leu Ser Val His Glu Ala Ser Trp 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Arg Trp Thr Thr Glu Arg Lys Leu Gly 
                85                  90  


<210>  39
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutN bdSENP1

<400>  39

Gly Gly Arg Lys Ser Ser Glu Thr Leu Ser Val His Glu Ala Ser Pro 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Arg Trp Thr Thr Arg Arg Lys Leu Gly 
                85                  90  


<210>  40
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  MutO bdSENP1

<400>  40

Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser Arg 
1               5                   10                  15      


Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu Trp 
            20                  25                  30          


Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu Arg 
        35                  40                  45              


Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn Thr 
    50                  55                  60                  


Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser Val 
65                  70                  75                  80  


Arg Gly Trp Thr Thr Leu Arg Lys Leu Gly 
                85                  90  


<210>  41
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut1 bdSUMO residues 1-97

<400>  41

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Lys Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Arg Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  42
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut2 bdSUMO residues 1-97

<400>  42

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Thr Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Cys Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  43
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut3 bdSUMO residues 1-97

<400>  43

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met His Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Lys Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  44
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut4 bdSUMO residues 1-97

<400>  44

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Arg Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Arg Gly Arg Arg Leu Arg Ala Glu Val Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  45
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut5 bdSUMO residues 1-97

<400>  45

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Thr Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Phe Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  46
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut6 bdSUMO residues 1-97

<400>  46

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met His Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Gln Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  47
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut7 bdSUMO residues 1-97

<400>  47

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Asp Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Arg Gly Arg Arg Leu Arg Ala Glu Cys Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  48
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut8 bdSUMO residues 1-97

<400>  48

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Pro Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Gln Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  49
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut9 bdSUMO residues 1-97

<400>  49

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Ala Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Tyr Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  50
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut10 bdSUMO residues 1-97

<400>  50

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Thr Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Arg Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  51
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut11 bdSUMO residues 1-97

<400>  51

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Ser Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Trp Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  52
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut12 bdSUMO residues 1-97

<400>  52

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Ser Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu His Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  53
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut13 bdSUMO residues 1-97

<400>  53

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Ser Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Ala Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  54
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut14 bdSUMO residues 1-97

<400>  54

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Asn Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Trp Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  55
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Mut15 bdSUMO residues 1-97

<400>  55

Met Ser Ala Ala Gly Gly Glu Glu Asp Lys Lys Pro Ala Gly Gly Glu 
1               5                   10                  15      


Gly Gly Gly Ala His Ile Asn Leu Lys Val Lys Gly Gln Asp Gly Asn 
            20                  25                  30          


Glu Val Phe Phe Arg Ile Lys Arg Ser Thr Gln Leu Lys Lys Leu Met 
        35                  40                  45              


Asn Ala Tyr Cys Asp Arg Gln Ser Val Asp Met Asn Ala Ile Ala Phe 
    50                  55                  60                  


Leu Phe Lys Gly Arg Arg Leu Arg Ala Glu Ala Thr Pro Asp Glu Leu 
65                  70                  75                  80  


Glu Met Glu Asp Gly Asp Glu Ile Asp Ala Met Leu His Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  56
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutA bdSENP1 residues 248-481

<400>  56

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Gly Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Glu Trp Thr Thr Pro Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  57
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutB bdSENP1 residues 248-481

<400>  57

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Ser Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Glu Trp Thr Thr Lys Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  58
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutC bdSENP1 residues 248-481

<400>  58

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Ser Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Ala Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Gly Trp Thr Thr Val Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  59
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutD bdSENP1 residues 248-481

<400>  59

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Glu Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Glu Trp Thr Thr Gln Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  60
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutE bdSENP1 residues 248-481

<400>  60

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Gly Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Tyr Trp Thr Thr Ala Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  61
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutF bdSENP1 residues 248-481

<400>  61

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Cys Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Leu Trp Thr Thr Arg Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  62
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  MutG bdSENP1 residues 248-481

<400>  62

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Ser Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


His Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Arg Trp Thr Thr Val Lys Leu Gly Tyr Asn Leu Ile Asp Cys 
            100                 105                 110         


Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu Ala 
        115                 120                 125             


Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu Gly 
    130                 135                 140                 


Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val Asp 
145                 150                 155                 160 


Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp Lys 
                165                 170                 175     


Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp Cys 
            180                 185                 190         


Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met Glu 
        195                 200                 205             


Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr Ala 
    210                 215                 220                 


Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230             


<210>  63
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  MutH bdSENP1 residues 248-481

<400>  63

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Pro Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Ala Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Tyr Asp Tyr Lys Ser Val 
                85                  90                  95      


Arg Glu Trp Thr Thr Met Arg Lys Leu Gly Tyr Asn Leu Ile Asp Cys 
            100                 105                 110         


Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu Ala 
        115                 120                 125             


Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu Gly 
    130                 135                 140                 


Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val Asp 
145                 150                 155                 160 


Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp Lys 
                165                 170                 175     


Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp Cys 
            180                 185                 190         


Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met Glu 
        195                 200                 205             


Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr Ala 
    210                 215                 220                 


Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230             


<210>  64
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  Muti bdSENP1 residues 248-481

<400>  64

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Lys Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


His Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Glu Trp Thr Thr Arg Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  65
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutJ bdSENP1 residues 248-481

<400>  65

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Glu Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Ser Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Ser Trp Thr Thr Thr Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  66
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutK bdSENP1 residues 248-481

<400>  66

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Val Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Gln Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Val Trp Thr Thr Gly Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  67
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutL bdSENP1 residues 248-481

<400>  67

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Leu Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Val Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Pro Trp Thr Thr Ala Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  68
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutM bdSENP1 residues 248-481

<400>  68

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Ala Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Trp Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Arg Trp Thr Thr Glu Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  69
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutN bdSENP1 residues 248-481

<400>  69

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Ser Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Pro Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Arg Trp Thr Thr Arg Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  70
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  MutO bdSENP1 residues 248-481

<400>  70

Pro Phe Val Pro Leu Thr Asp Glu Asp Glu Asp Asn Val Arg His Ala 
1               5                   10                  15      


Leu Gly Gly Arg Lys Arg Ser Glu Thr Leu Ser Val His Glu Ala Ser 
            20                  25                  30          


Arg Ile Val Ile Thr Arg Glu Ile Leu Gln Cys Leu Asn Asp Lys Glu 
        35                  40                  45              


Trp Leu Asn Asp Glu Val Ile Asn Leu Tyr Leu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Arg Glu Leu Arg Glu Pro Asn Lys Phe Leu Lys Cys His Phe Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Tyr Lys Lys Leu Ile Asn Gly Gly Tyr Asp Tyr Lys Ser 
                85                  90                  95      


Val Arg Gly Trp Thr Thr Leu Arg Lys Leu Gly Tyr Asn Leu Ile Asp 
            100                 105                 110         


Cys Asp Lys Ile Phe Val Pro Ile His Lys Asp Val His Trp Cys Leu 
        115                 120                 125             


Ala Val Ile Asn Ile Lys Glu Lys Lys Phe Gln Tyr Leu Asp Ser Leu 
    130                 135                 140                 


Gly Tyr Met Asp Met Lys Ala Leu Arg Ile Leu Ala Lys Tyr Leu Val 
145                 150                 155                 160 


Asp Glu Val Lys Asp Lys Ser Gly Lys Gln Ile Asp Val His Ala Trp 
                165                 170                 175     


Lys Gln Glu Gly Val Gln Asn Leu Pro Leu Gln Glu Asn Gly Trp Asp 
            180                 185                 190         


Cys Gly Met Phe Met Leu Lys Tyr Ile Asp Phe Tyr Ser Arg Asp Met 
        195                 200                 205             


Glu Leu Val Phe Gly Gln Lys His Met Ser Tyr Phe Arg Arg Arg Thr 
    210                 215                 220                 


Ala Lys Glu Ile Leu Asp Leu Lys Ala Gly 
225                 230                 


<210>  71
<211>  373
<212>  PRT
<213>  Artificial

<220>
<223>  MBP fusion

<400>  71

Ala Gly Thr Gly Thr Ser Lys Thr Glu Glu Gly Lys Leu Val Ile Trp 
1               5                   10                  15      


Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys 
            20                  25                  30          


Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys 
        35                  40                  45              


Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp 
    50                  55                  60                  


Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly 
65                  70                  75                  80  


Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr 
                85                  90                  95      


Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr 
            100                 105                 110         


Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu 
        115                 120                 125             


Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu 
    130                 135                 140                 


Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro 
145                 150                 155                 160 


Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys 
                165                 170                 175     


Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala 
            180                 185                 190         


Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys 
        195                 200                 205             


His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn 
    210                 215                 220                 


Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn 
225                 230                 235                 240 


Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe 
                245                 250                 255     


Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile 
            260                 265                 270         


Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn 
        275                 280                 285             


Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro 
    290                 295                 300                 


Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met 
                325                 330                 335     


Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala 
            340                 345                 350         


Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys 
        355                 360                 365             


Asp Ala Gln Thr Asn 
    370             


<210>  72
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  RBS

<400>  72
aaaacaaguu auccaug                                                      17


