                         SEQUENCE LISTING

<110>  Emory University
       Children's Healthcare of Atlanta, Inc.
       Mainou, Bernardo
       Rodriguez, Roxana
       Berger, Angela
       Berry, Jameson
 
<120>  Modified Reoviruses, Particles, and Uses in Treating 
       Proliferative Disorders

<130>  16161 PCT

<150>  US 62/681,857
<151>  2018-06-07

<150>  US 62/682,216
<151>  2018-06-08

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  1

Met Lys Arg Ile Pro Arg Lys Thr Lys Gly Lys Ser Ser Gly Lys Gly 
1               5                   10                  15      


Asn Asp Ser Thr Glu Arg Ala Asp Asp Gly Ser Ser Gln Leu Arg Asp 
            20                  25                  30          


Lys Gln Asn Asn Lys Ala Gly Pro Ala Thr Thr Glu Pro Gly Thr Ser 
        35                  40                  45              


Asn Arg Glu Gln Tyr Lys Ala Arg Pro Gly Ile Ala Ser Val Gln Arg 
    50                  55                  60                  


Ala Thr Glu Ser Ala Glu Met Pro Met Lys Asn Asn Asp Glu Gly Thr 
65                  70                  75                  80  


Pro Asp Lys Lys Gly Asn Thr Lys Gly Asp Leu Val Asn Glu His Ser 
                85                  90                  95      


Glu Ala Lys Asp Glu Ala Asp Glu Ala Thr Lys Lys Gln Ala Lys Asp 
            100                 105                 110         


Thr Asp Lys Ser Lys Ala Gln Val Thr Tyr Ser Asp Thr Gly Ile Asn 
        115                 120                 125             


Asn Ala Asn Glu Leu Ser Arg Ser Gly Asn Val Asp Asn Glu Gly Gly 
    130                 135                 140                 


Ser Asn Gln Lys Pro Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala 
145                 150                 155                 160 


Ile Val Ser Lys His Pro Ala Arg 
                165             


<210>  2
<211>  418
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  2

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu 
1               5                   10                  15      


Gln Asn Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala 
            20                  25                  30          


Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu 
        35                  40                  45              


Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg 
    50                  55                  60                  


Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe 
65                  70                  75                  80  


Arg Pro Asn His Arg Trp Gly Asp Ile Arg Phe Leu Arg Leu Val Trp 
                85                  90                  95      


Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu 
            100                 105                 110         


Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp 
        115                 120                 125             


Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr 
    130                 135                 140                 


Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro 
145                 150                 155                 160 


Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn 
                165                 170                 175     


Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr 
            180                 185                 190         


Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu Tyr Asp Gly Thr 
        195                 200                 205             


Tyr Ala Arg Met Thr Gln Ile Val Leu Ser Leu Phe Trp Leu Ser Tyr 
    210                 215                 220                 


Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln 
225                 230                 235                 240 


Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser 
                245                 250                 255     


Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val 
            260                 265                 270         


Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser 
        275                 280                 285             


Ser Thr Leu Thr Gly Cys Leu Cys Ser Gly Ser Gln Leu Pro Leu Ile 
    290                 295                 300                 


Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr 
305                 310                 315                 320 


Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val 
                325                 330                 335     


Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala 
            340                 345                 350         


Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys 
        355                 360                 365             


Arg Asp Lys Leu Glu Thr Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln 
    370                 375                 380                 


Ala His Pro Asn Ser Thr Met Phe Arg Thr Lys Pro Phe Thr Asn Ala 
385                 390                 395                 400 


Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala 
                405                 410                 415     


Leu Ile 
        


<210>  3
<211>  270
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  3

Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp 
1               5                   10                  15      


Val Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val 
            20                  25                  30          


Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly 
        35                  40                  45              


Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys 
    50                  55                  60                  


Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg 
65                  70                  75                  80  


Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro 
                85                  90                  95      


Asp Ala Pro Met Ser Asn His Gln Ala Ala Thr Met Arg Glu Leu Ile 
            100                 105                 110         


Cys Ser Tyr Phe Lys Val Asp His Thr Asp Gly Leu Lys Tyr Ile Pro 
        115                 120                 125             


Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met 
    130                 135                 140                 


Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val 
145                 150                 155                 160 


Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu 
                165                 170                 175     


Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro 
            180                 185                 190         


Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala 
        195                 200                 205             


Cys Met Asp Ile Ser Tyr Gly Cys Glu Val Asp Ala Ser Asn Arg Ser 
    210                 215                 220                 


Ala Gly Asp Gln Ser Met Asp Ser Ser Arg Cys Ile Asn Glu Leu Tyr 
225                 230                 235                 240 


Cys Glu Glu Thr Ala Glu Ala Ile Cys Ile Leu Lys Thr Cys Leu Val 
                245                 250                 255     


Leu Asn Cys Met Gln Phe Lys Leu Glu Met Asp Asp Leu Ala 
            260                 265                 270 


<210>  4
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  4

Met Glu Val Cys Leu Pro Asn Gly His Gln Val Val Asp Leu Ile Asn 
1               5                   10                  15      


Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Glu Gly Trp 
            20                  25                  30          


Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Gly Ala 
        35                  40                  45              


Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys 
    50                  55                  60                  


Leu Lys His Leu Pro His His Arg Cys Asn Gln Gln Ile Arg His Gln 
65                  70                  75                  80  


Asp Tyr Val Asp Val Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys 
                85                  90                  95      


Arg Gly Met Leu Ser Phe 
            100         


<210>  5
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  5

Gly Val Met Thr Gln Ala Gln Gln Asn Gln Ile Glu Ala Leu Ala Asp 
1               5                   10                  15      


Gln Thr Gln Gln Phe 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  6

Gly Val Met Thr Gln Ala Gln Gln Asn Gln Val Glu Ala Leu Ala Asp 
1               5                   10                  15      


Gln Thr Gln Gln Phe 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  7

Ala Arg Glu Asp Asp Gln Tyr Asn Gln Ala Asn Pro Asn Ser Thr Met 
1               5                   10                  15      


Phe Arg Thr Lys Pro 
            20      


<210>  8
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  8

Ala Arg Glu Asp Asp Gln Tyr Asn Gln Ala His Pro Asn Ser Thr Met 
1               5                   10                  15      


Phe Arg Thr Lys Pro 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  9

Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val Pro Ile Met His Leu Ala 
1               5                   10                  15      


Ala Asp Leu Asp Cys 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  10

Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val Thr Ile Met His Leu Ala 
1               5                   10                  15      


Ala Asp Leu Asp Cys 
            20      


<210>  11
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  11

Tyr Cys Glu Glu Thr Ala Glu Ala Ile Cys Ile Leu Lys Thr Cys Leu 
1               5                   10                  15      


Val Leu Asn Cys Met 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  12

Tyr Cys Glu Glu Thr Ala Glu Ala Ile Cys Val Leu Lys Thr Cys Leu 
1               5                   10                  15      


Val Leu Asn Cys Met 
            20      


<210>  13
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  13

Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala Ile Val Ser Lys His 
1               5                   10                  15      


Pro Ala Arg Val Gly 
            20      


<210>  14
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  14

Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Thr Ile Val Ser Lys His 
1               5                   10                  15      


Pro Ala Arg Val Gly 
            20      


<210>  15
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  15

Gln Pro Asp Met Met Val Cys Gly Gly Ala Val Val Cys Met His Cys 
1               5                   10                  15      


Leu Gly Val Val Gly 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  16

Gln Pro Asp Met Met Val Cys Gly Gly Ala Ile Val Cys Met His Cys 
1               5                   10                  15      


Leu Gly Val Val Gly 
            20      


