                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> IMPROVED VIRUS-LIKE NANOPARTICLES FOR ORAL DELIVERY

<130> 081906-1131456-230110PC

<140> PCT/US2019/035823
<141> 2019-06-06

<150> 62/681,637
<151> 2018-06-06

<160> 15    

<170> PatentIn version 3.5

<210> 1
<211> 660
<212> PRT
<213> Hepatitis E virus

<400> 1
Met Arg Pro Arg Pro Ile Leu Leu Leu Leu Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Ala Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Ala 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu His Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Leu Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Thr Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Met Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210> 2
<211> 660
<212> PRT
<213> Hepatitis E virus

<400> 2
Met Arg Pro Arg Ala Val Leu Leu Leu Phe Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Val Ser Gln Ser Gly Ala Gly Ala Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Ala 
                85                  90                  95      


Ala Pro Arg Arg Arg Ser Ala Pro Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Ile Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Thr Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210> 3
<211> 660
<212> PRT
<213> Hepatitis E virus

<400> 3
Met Arg Pro Arg Ala Val Leu Leu Leu Phe Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Thr Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser 
    50                  55                  60                  


Asp Ile Pro Thr Ala Thr Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala 
                85                  90                  95      


Pro Ala Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Thr Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Ile Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Ser Ala Arg His Lys Leu Cys Arg Gly Pro Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Leu Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Phe Val Asn Val Ala Thr Gly Thr Gln Gly Val Ser Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Pro Gly 
                565                 570                 575     


His Arg Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Ala Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Gln Glu Tyr 
            660 


<210> 4
<211> 659
<212> PRT
<213> Hepatitis E virus

<400> 4
Met Arg Pro Arg Pro Leu Leu Leu Leu Phe Leu Leu Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Thr Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Thr Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Ala Ala Ala Ser Gly Ser Gly Pro Arg Leu Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Thr Trp Arg Asp Gln Ala Gln Arg Pro Ser Ala 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Ala Thr Ala Gly Ala Ala Ala Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Ser Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Pro Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Thr Cys Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Ser Ala Arg Gly Ala Asp Gly 
                325                 330                 335     


Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu 
            340                 345                 350         


His Phe Thr Gly Leu Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala 
        355                 360                 365             


Leu Thr Leu Leu Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr 
    370                 375                 380                 


Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val 
385                 390                 395                 400 


Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu 
                405                 410                 415     


Asn Ala Gln Gln Asp Lys Gly Val Ala Ile Pro His Asp Ile Asp Leu 
            420                 425                 430         


Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln 
        435                 440                 445             


Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu 
    450                 455                 460                 


Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp 
465                 470                 475                 480 


Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Ile Ser Asp Ser 
                485                 490                 495     


Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser 
            500                 505                 510         


Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Pro Thr Val 
        515                 520                 525             


Glu Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu 
    530                 535                 540                 


Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr 
545                 550                 555                 560 


Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His 
                565                 570                 575     


Arg Val Ala Ile Ser Thr Tyr Thr Thr Arg Leu Gly Ala Gly Pro Val 
            580                 585                 590         


Ala Ile Ser Ala Ala Ala Val Leu Ala Pro Arg Ser Ala Leu Ala Leu 
        595                 600                 605             


Leu Glu Asp Thr Phe Asp Tyr Pro Gly Arg Ala His Thr Phe Asp Asp 
    610                 615                 620                 


Phe Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln 
625                 630                 635                 640 


Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Val Lys Val Gly Lys Thr 
                645                 650                 655     


Arg Glu Leu 
            


<210> 5
<211> 674
<212> PRT
<213> Hepatitis E virus


<220>
<221> MOD_RES
<222> (368)..(368)
<223> Any amino acid

<400> 5
Met Asn Asn Met Phe Leu Cys Phe Ala Cys Gly Tyr Ala Thr Met Arg 
1               5                   10                  15      


Pro Arg Ala Ile Leu Leu Leu Leu Val Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Ser Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Ser Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Thr 
65                  70                  75                  80  


Ile Ala Ala Thr Gly Thr Gly Ala Arg Ser Arg Gln Ser Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Thr Gln Arg Pro Pro Ala Ala Ser 
            100                 105                 110         


Arg Arg Arg Ser Thr Pro Thr Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Arg Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Val Val Gln Pro Gly Leu Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Thr Ala Arg His Arg Leu His Arg Gly Ala Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu Xaa 
        355                 360                 365             


Phe Thr Gly Ser Asn Gly Ile Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Val Asn Asp Val Leu Trp Leu Thr Met Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Thr Ser Thr Asp Pro Val Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ala Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln 
    530                 535                 540                 


Arg His Ser Lys Asn Tyr Phe Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Val Ser Gly Val Gly Val Leu Ala Pro His Ala Ala Leu Ala Val Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Arg Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Phe 
        


<210> 6
<211> 660
<212> PRT
<213> Hepatitis E virus

<400> 6
Met Arg Pro Arg Ala Val Leu Leu Leu Phe Leu Met Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser 
    50                  55                  60                  


Asp Val Ser Thr Ser Ala Gly Ala Gly Ala Arg Ala Arg Gln Ala Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Ala 
                85                  90                  95      


Ser Ala Arg Arg Arg Pro Thr Pro Ala Gly Ala Ser Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala Pro Asp Thr Thr Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Thr Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Gly Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ile Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Leu 
225                 230                 235                 240 


Ala Ser Glu Leu Ile Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Pro Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Gly Ser Asn Gly Leu Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Glu Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Thr Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Val Asn Asp Val Leu Trp Leu Thr Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Thr Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ala Arg 
            500                 505                 510         


Ala Leu Asp Trp Ser Lys Val Thr Phe Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Val Gln Gln Tyr Gly Lys Ser Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Val Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Val Glu Asn Ala Pro Gly 
                565                 570                 575     


His Arg Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ala Ala Thr Ala 
        595                 600                 605             


Ala Leu Glu Asp Thr Ala Asp Ser Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Ile Leu Gly Leu Gln Gly Cys Ala Tyr 
625                 630                 635                 640 


Gln Ser Thr Ala Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Ser Arg Glu Phe 
            660 


<210> 7
<211> 497
<212> PRT
<213> Hepatitis E virus

<400> 7
Ala Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser 
1               5                   10                  15      


Arg Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu 
            20                  25                  30          


Thr Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro 
        35                  40                  45              


Leu Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met 
    50                  55                  60                  


Ala Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr 
65                  70                  75                  80  


Ile Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile 
                85                  90                  95      


Ser Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp 
            100                 105                 110         


Met Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly 
        115                 120                 125             


Ile Ala Ser Glu His Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn 
    130                 135                 140                 


Gln Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Leu Val Asn Ser 
                165                 170                 175     


Tyr Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala 
            180                 185                 190         


Leu Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg 
        195                 200                 205             


Val Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala 
    210                 215                 220                 


Asp Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys 
225                 230                 235                 240 


Asp Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly 
                245                 250                 255     


Ile Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu 
            260                 265                 270         


Pro Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg 
        275                 280                 285             


Pro Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser 
    290                 295                 300                 


Val Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile 
305                 310                 315                 320 


Asp Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His 
                325                 330                 335     


Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser 
            340                 345                 350         


Val Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu 
        355                 360                 365             


Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser 
    370                 375                 380                 


Asp Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala 
385                 390                 395                 400 


Arg Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser 
                405                 410                 415     


Thr Thr Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly 
            420                 425                 430         


Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr 
        435                 440                 445             


Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala 
    450                 455                 460                 


Gly His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly 
465                 470                 475                 480 


Pro Val Ser Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Ala Leu 
                485                 490                 495     


Ala 
    


<210> 8
<211> 497
<212> PRT
<213> Hepatitis E virus

<400> 8
Ala Ile Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser 
1               5                   10                  15      


Arg Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu 
            20                  25                  30          


Thr Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro 
        35                  40                  45              


Leu Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met 
    50                  55                  60                  


Ala Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr 
65                  70                  75                  80  


Ile Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile 
                85                  90                  95      


Ser Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp 
            100                 105                 110         


Met Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly 
        115                 120                 125             


Ile Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn 
    130                 135                 140                 


Gln Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser 
                165                 170                 175     


Tyr Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala 
            180                 185                 190         


Leu Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg 
        195                 200                 205             


Val Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala 
    210                 215                 220                 


Asp Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys 
225                 230                 235                 240 


Asp Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly 
                245                 250                 255     


Ile Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu 
            260                 265                 270         


Pro Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg 
        275                 280                 285             


Pro Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser 
    290                 295                 300                 


Val Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile 
305                 310                 315                 320 


Asp Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His 
                325                 330                 335     


Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser 
            340                 345                 350         


Val Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu 
        355                 360                 365             


Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser 
    370                 375                 380                 


Asp Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala 
385                 390                 395                 400 


Arg Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr 
                405                 410                 415     


Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly 
            420                 425                 430         


Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr 
        435                 440                 445             


Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala 
    450                 455                 460                 


Gly His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly 
465                 470                 475                 480 


Pro Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu 
                485                 490                 495     


Ala 
    


<210> 9
<211> 497
<212> PRT
<213> Hepatitis E virus

<400> 9
Ala Val Ala Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser 
1               5                   10                  15      


Arg Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu 
            20                  25                  30          


Thr Ser Thr Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro 
        35                  40                  45              


Leu Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Ile 
    50                  55                  60                  


Ala Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr 
65                  70                  75                  80  


Ile Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile 
                85                  90                  95      


Ser Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp 
            100                 105                 110         


Met Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly 
        115                 120                 125             


Ile Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn 
    130                 135                 140                 


Gln Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser 
                165                 170                 175     


Tyr Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala 
            180                 185                 190         


Leu Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg 
        195                 200                 205             


Val Ser Arg Tyr Ser Ser Ser Ala Arg His Lys Leu Cys Arg Gly Pro 
    210                 215                 220                 


Asp Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys 
225                 230                 235                 240 


Asp Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly 
                245                 250                 255     


Ile Ala Leu Thr Leu Leu Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu 
            260                 265                 270         


Pro Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg 
        275                 280                 285             


Pro Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser 
    290                 295                 300                 


Val Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile 
305                 310                 315                 320 


Asp Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His 
                325                 330                 335     


Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser 
            340                 345                 350         


Val Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu 
        355                 360                 365             


Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser 
    370                 375                 380                 


Asp Thr Val Thr Phe Val Asn Val Ala Thr Gly Thr Gln Gly Val Ser 
385                 390                 395                 400 


Arg Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr 
                405                 410                 415     


Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly 
            420                 425                 430         


Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr 
        435                 440                 445             


Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Pro 
    450                 455                 460                 


Gly His Arg Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Pro Val Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu 
                485                 490                 495     


Ala 
    


<210> 10
<211> 497
<212> PRT
<213> Hepatitis E virus

<400> 10
Ala Val Ala Pro Ala His Asp Thr Ser Pro Val Pro Asp Val Asp Ser 
1               5                   10                  15      


Arg Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu 
            20                  25                  30          


Thr Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro 
        35                  40                  45              


Leu Asn Pro Pro Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met 
    50                  55                  60                  


Ala Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr 
65                  70                  75                  80  


Ile Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile 
                85                  90                  95      


Ser Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp 
            100                 105                 110         


Met Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly 
        115                 120                 125             


Ile Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn 
    130                 135                 140                 


Gln Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser 
                165                 170                 175     


Tyr Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala 
            180                 185                 190         


Leu Glu Leu Glu Phe Arg Asn Leu Thr Thr Cys Asn Thr Asn Thr Arg 
        195                 200                 205             


Val Ser Arg Tyr Ser Ser Thr Ala Arg His Ser Ala Arg Gly Ala Asp 
    210                 215                 220                 


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
225                 230                 235                 240 


Leu His Phe Thr Gly Leu Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
                245                 250                 255     


Ala Leu Thr Leu Leu Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
            260                 265                 270         


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
        275                 280                 285             


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
    290                 295                 300                 


Glu Asn Ala Gln Gln Asp Lys Gly Val Ala Ile Pro His Asp Ile Asp 
305                 310                 315                 320 


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
                325                 330                 335     


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
            340                 345                 350         


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
        355                 360                 365             


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Ile Ser Asp 
    370                 375                 380                 


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
385                 390                 395                 400 


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Pro Thr 
                405                 410                 415     


Val Glu Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
            420                 425                 430         


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
        435                 440                 445             


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
    450                 455                 460                 


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Arg Leu Gly Ala Gly Pro 
465                 470                 475                 480 


Val Ala Ile Ser Ala Ala Ala Val Leu Ala Pro Arg Ser Ala Leu Ala 
                485                 490                 495     


Leu 
    


<210> 11
<211> 497
<212> PRT
<213> Hepatitis E virus


<220>
<221> MOD_RES
<222> (257)..(257)
<223> Any amino acid

<400> 11
Ser Arg Arg Arg Ser Thr Pro Thr Gly Ala Ser Pro Leu Thr Ala Val 
1               5                   10                  15      


Ala Pro Ala Pro Asp Thr Arg Pro Val Pro Asp Val Asp Ser Arg Gly 
            20                  25                  30          


Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser 
        35                  40                  45              


Thr Ile Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser 
    50                  55                  60                  


Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr 
65                  70                  75                  80  


Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg 
                85                  90                  95      


Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile 
            100                 105                 110         


Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn 
        115                 120                 125             


Ser Ile Thr Ser Thr Asp Val Arg Ile Val Val Gln Pro Gly Leu Ala 
    130                 135                 140                 


Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly 
145                 150                 155                 160 


Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser 
                165                 170                 175     


Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr 
            180                 185                 190         


Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu 
        195                 200                 205             


Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser 
    210                 215                 220                 


Arg Tyr Ser Ser Thr Ala Arg His Arg Leu His Arg Gly Ala Asp Gly 
225                 230                 235                 240 


Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu 
                245                 250                 255     


Xaa Phe Thr Gly Ser Asn Gly Ile Gly Glu Val Gly Arg Gly Ile Ala 
            260                 265                 270         


Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr 
        275                 280                 285             


Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val 
    290                 295                 300                 


Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu 
305                 310                 315                 320 


Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu 
                325                 330                 335     


Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln 
            340                 345                 350         


Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu 
        355                 360                 365             


Arg Val Asn Asp Val Leu Trp Leu Thr Met Thr Ala Ala Glu Tyr Asp 
    370                 375                 380                 


Gln Thr Thr Tyr Gly Thr Ser Thr Asp Pro Val Tyr Val Ser Asp Thr 
385                 390                 395                 400 


Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ala Arg Ser 
                405                 410                 415     


Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile 
            420                 425                 430         


Gln Arg His Ser Lys Asn Tyr Phe Val Leu Pro Leu Arg Gly Lys Leu 
        435                 440                 445             


Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr 
    450                 455                 460                 


Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His 
465                 470                 475                 480 


Arg Val Cys Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ser Gly Pro Val 
                485                 490                 495     


Ser 
    


<210> 12
<211> 497
<212> PRT
<213> Hepatitis E virus

<400> 12
Ala Val Ala Pro Ala Pro Asp Thr Thr Pro Val Pro Asp Val Asp Ser 
1               5                   10                  15      


Arg Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu 
            20                  25                  30          


Thr Ser Thr Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro 
        35                  40                  45              


Leu Gly Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met 
    50                  55                  60                  


Ala Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ile Arg Ala Thr 
65                  70                  75                  80  


Ile Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile 
                85                  90                  95      


Ser Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp 
            100                 105                 110         


Met Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly 
        115                 120                 125             


Leu Ala Ser Glu Leu Ile Ile Pro Ser Glu Arg Leu His Tyr Arg Asn 
    130                 135                 140                 


Gln Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser 
                165                 170                 175     


Tyr Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala 
            180                 185                 190         


Leu Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg 
        195                 200                 205             


Val Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Pro 
    210                 215                 220                 


Asp Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys 
225                 230                 235                 240 


Asp Leu Tyr Phe Thr Gly Ser Asn Gly Leu Gly Glu Val Gly Arg Gly 
                245                 250                 255     


Ile Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu 
            260                 265                 270         


Pro Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg 
        275                 280                 285             


Pro Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser 
    290                 295                 300                 


Val Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Glu Ile 
305                 310                 315                 320 


Asp Leu Gly Asp Ser Arg Val Thr Ile Gln Asp Tyr Asp Asn Gln His 
                325                 330                 335     


Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser 
            340                 345                 350         


Val Leu Arg Val Asn Asp Val Leu Trp Leu Thr Leu Thr Ala Ala Glu 
        355                 360                 365             


Tyr Asp Gln Thr Thr Tyr Gly Ser Thr Thr Asn Pro Met Tyr Val Ser 
    370                 375                 380                 


Asp Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ala 
385                 390                 395                 400 


Arg Ala Leu Asp Trp Ser Lys Val Thr Phe Asp Gly Arg Pro Leu Thr 
                405                 410                 415     


Thr Val Gln Gln Tyr Gly Lys Ser Phe Phe Val Leu Pro Leu Arg Gly 
            420                 425                 430         


Lys Leu Ser Phe Trp Glu Ala Gly Thr Val Lys Ala Gly Tyr Pro Tyr 
        435                 440                 445             


Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Val Glu Asn Ala Pro 
    450                 455                 460                 


Gly His Arg Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Pro Val Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ala Ala Thr 
                485                 490                 495     


Ala 
    


<210> 13
<211> 6
<212> PRT
<213> Hepatitis E virus

<400> 13
Leu Asp Gly Arg Pro Leu 
1               5       


<210> 14
<211> 7
<212> PRT
<213> Hepatitis E virus

<400> 14
Val Ser Ala Asn Gly Glu Pro 
1               5           


<210> 15
<211> 7
<212> PRT
<213> Hepatitis E virus

<400> 15
Thr Leu Asp Gly Arg Pro Leu 
1               5           


