                               SEQUENCE LISTING

<110> LIFEEDIT, INC
 
<120> RNA-GUIDED NUCLEASES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF 
      AND METHODS OF USE

<130> L103438 1160WO (0029.8)

<140>
<141>

<150> 62/805,045
<151> 2019-02-13

<150> 62/805,041
<151> 2019-02-13

<150> 62/686,901
<151> 2018-06-19

<150> 62/680,863
<151> 2018-06-05

<150> 62/680,862
<151> 2018-06-05

<150> 62/680,859
<151> 2018-06-05

<150> 62/680,853
<151> 2018-06-05

<150> 62/680,846
<151> 2018-06-05

<150> 62/680,845
<151> 2018-06-05

<160> 651   

<170> PatentIn version 3.5

<210> 1
<211> 1070
<212> PRT
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG05083.1"

<400> 1
Met Arg Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Gly Ile Ile Glu Leu Ser Trp Asn Lys Asp Arg Glu Gln 
            20                  25                  30          


Tyr Glu Lys Ala Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys 
        35                  40                  45              


Ala Glu Ile Pro Lys Thr Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile 
    50                  55                  60                  


Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  


Asp Ile Arg Asn Leu Leu Val Gln His Glu Ile Ile Ser Gln Lys Glu 
                85                  90                  95      


Leu Ala Ser Leu Tyr Pro Leu Thr Lys Ser Ser Met Asp Ile Trp Asp 
            100                 105                 110         


Ile Arg Leu Asp Gly Leu Asp Arg Leu Leu Asp Arg Phe Glu Trp Thr 
        115                 120                 125             


Arg Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 


Lys Ser Glu Leu Lys Asp Val Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 


Gln Ala Asn Glu Lys Arg Leu Ser Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     


Trp Met Lys Asn Glu Asp Phe Ser Lys Tyr Asp Lys Arg Arg Asn Ser 
            180                 185                 190         


Ser Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu 
        195                 200                 205             


Ile Val Thr Leu Phe Glu Ala Gln Arg Lys Phe Gln Ser Ser Tyr Ala 
    210                 215                 220                 


Ser Ala Asp Leu Gln Lys Thr Tyr Leu Gln Ile Trp Ala His Gln Leu 
225                 230                 235                 240 


Pro Phe Ala Ser Gly Asn Ala Ile Val Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     


Leu Leu Lys Gly Lys Glu Lys Arg Val Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         


Gln Tyr Phe Ser Thr Leu Asp Gln Ile Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             


Asn Phe Gln Pro Phe Thr Lys Glu Gln Arg Asp Val Ile Leu Asp Glu 
    290                 295                 300                 


Met Phe Asn Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 


Thr Tyr Tyr Asp Ile Arg Lys Trp Leu Ala Leu Asp Glu Thr Ile Gln 
                325                 330                 335     


Phe Lys Gly Leu Thr Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         


Leu Lys Ser Phe Ile Asn Leu Lys Pro Phe Tyr Glu Ile Lys Lys Val 
        355                 360                 365             


Val Thr Asn Tyr Ala Lys Lys Thr Asn Glu Ala Phe Ser Thr Leu Asp 
    370                 375                 380                 


Tyr Asp Thr Phe Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 


Ile Arg Ser Tyr Leu Lys Lys Ser Asn Asn Leu Ser Lys Cys Cys Tyr 
                405                 410                 415     


Asp Asp Gln Leu Ile Glu Glu Leu Leu Thr Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         


Gly His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln 
        435                 440                 445             


Glu Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Ala 
    450                 455                 460                 


Thr Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Phe Pro 
465                 470                 475                 480 


Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Leu Thr Gln Ala Arg 
                485                 490                 495     


Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val 
            500                 505                 510         


His Ile Glu Leu Ala Arg Glu Leu Ser Lys Ser His Asp Glu Arg Thr 
        515                 520                 525             


Lys Ile Met Lys Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 


Ile Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 


Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr 
                565                 570                 575     


Ser Leu Lys Gln Ile Pro Ala Asn Thr Phe Phe Asn Glu Met Lys Lys 
            580                 585                 590         


Glu Arg Ser Gly Ser Pro Val Leu Glu Ile Asp His Ile Leu Pro Tyr 
        595                 600                 605             


Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Gly 
    610                 615                 620                 


Asp Glu Asn Gln Lys Lys Gly Asn Arg Ile Pro Tyr Thr Tyr Phe Leu 
625                 630                 635                 640 


Glu Gly Asn Lys Asp Trp Glu Ser Phe Glu Ser Tyr Val Arg Leu Asn 
                645                 650                 655     


Ser Phe Phe Ser Lys Lys Lys Arg Gly Tyr Leu Leu Lys Lys Ala Tyr 
            660                 665                 670         


Leu Pro Arg Glu Ser Asn Met Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             


Arg Tyr Ala Ser Ser Tyr Leu Lys Asn Phe Ile Glu Lys Asn Leu Lys 
    690                 695                 700                 


Phe Lys Glu Val Glu Gly Ser Thr Arg Lys Lys His Val Gln Thr Val 
705                 710                 715                 720 


Asn Gly Ile Ile Thr Ala His Leu Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     


Asp Arg Gln Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         


Ala Cys Thr Asp His His Met Val Thr Lys Val Thr Glu Tyr Tyr Gln 
        755                 760                 765             


Ile Lys Glu Ser Asn Lys Ser Ile Arg Lys Pro Tyr Phe Pro Leu Pro 
    770                 775                 780                 


Trp Val Gly Phe Arg Glu Glu Ile Leu Ser His Leu Ala Arg Gln Pro 
785                 790                 795                 800 


Ile Ala Arg Lys Ile Ser Glu Glu Leu Lys Ile Gly Tyr Gln Ser Phe 
                805                 810                 815     


Asp Tyr Ile Leu Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala 
            820                 825                 830         


Ala His Glu Gln Thr Ile Met Lys Lys Gly Gly Ile Asp Lys Lys Gly 
        835                 840                 845             


Lys Thr Ile Ile Ile Lys Arg Val Tyr Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 


Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Leu Ala Thr 
865                 870                 875                 880 


Tyr Glu Ala Ile Lys Gln Arg Tyr Ile Glu Tyr Gly Lys Glu Ser Lys 
                885                 890                 895     


Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Lys Gly 
            900                 905                 910         


Asn Leu Ile Lys Lys Ile Lys Val Glu Val Gln Thr Lys Ser Phe Val 
        915                 920                 925             


Arg Glu Val Asn Gly Gly Val Ala Gln Asn Gly Asp Leu Val Arg Val 
    930                 935                 940                 


Asp Leu Phe Glu Lys Asp Asn Arg Tyr Tyr Met Ile Pro Ile Tyr Val 
945                 950                 955                 960 


Met Asp Thr Val His Ser Glu Leu Pro Asn Lys Ala Val Thr Ser Ser 
                965                 970                 975     


Lys Gly Tyr Glu Gln Trp Leu Thr Ile Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         


Phe Ser Leu Tyr Pro Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asn Glu 
        995                 1000                 1005             


Asp Arg  Phe Leu Tyr Phe Ser  Thr Leu Asp Ile Asn  Ser Asp Arg 
    1010                 1015                 1020             


Leu Asn  Phe Lys Asp Val Asn  Lys Pro Ser Lys Gln  Ala Glu Asn 
    1025                 1030                 1035             


Arg Tyr  Ser Leu Lys Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val 
    1040                 1045                 1050             


Gly Val  Leu Gly Asp Leu Arg  Phe Val Arg Gln Glu  Ile Arg Lys 
    1055                 1060                 1065             


Asn Phe  
    1070 


<210> 2
<211> 19
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="crRNA"

<400> 2
gucauaguuc cauuauugc                                                    19


<210> 3
<211> 84
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 3
gcuuugaugu uucuaugaua agggcuuagg cccguggcgu uggggaucgc cugcccauuu       60

uaaugggcuu cuccccaucu auuu                                              84


<210> 4
<211> 137
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 4
gagcggacag cagcuuccua uaucucguac gucauaguuc cauuauugca aaggcuuuga       60

uguuucuaug auaagggcuu aggcccgugg cguuggggau cgccugccca uuuuaauggg      120

cuucucccca ucuauuu                                                     137


<210> 5
<211> 137
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 5
ccaugauaua gacguugugg cuguuguagu gucauaguuc cauuauugca aaggcuuuga       60

uguuucuaug auaagggcuu aggcccgugg cguuggggau cgccugccca uuuuaauggg      120

cuucucccca ucuauuu                                                     137


<210> 6
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PAM"


<220>
<221> modified_base
<222> (1)..(4)
<223> a, c, t, g, unknown or other

<400> 6
nnnncc                                                                   6


<210> 7
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PAM examplary"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 7
nnrncc                                                                   6


<210> 8
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 8
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 9
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 9
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 10
<211> 132
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 10
nnnnnnnnnn nnnnnnnnnn nnnnngucau aguuccauua uugcaaaggc uuugauguuu       60

cuaugauaag ggcuuaggcc cguggcguug gggaucgccu gcccauuuua augggcuucu      120

ccccaucuau uu                                                          132


<210> 11
<211> 1071
<212> PRT
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG07433.1"

<400> 11
Met Arg Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Gly Val Ile Glu Leu Ser Trp Asn Lys Asp Arg Glu Arg 
            20                  25                  30          


Tyr Glu Lys Val Arg Ile Val Asp Gln Gly Val Arg Met Phe Asp Arg 
        35                  40                  45              


Ala Glu Met Pro Lys Thr Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile 
    50                  55                  60                  


Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  


Asn Ile Arg Asn Leu Leu Val Gln His Gly Val Ile Thr Gln Glu Glu 
                85                  90                  95      


Leu Asp Ser Leu Tyr Pro Leu Ser Lys Lys Ser Met Asp Ile Trp Gly 
            100                 105                 110         


Ile Arg Leu Asp Gly Leu Asp Arg Leu Leu Asn His Phe Glu Trp Ala 
        115                 120                 125             


Arg Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 


Lys Ser Glu Leu Lys Asp Thr Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 


Gln Leu Asn Glu Lys Arg Leu Ser Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     


Trp Met Lys Asp Pro Asp Phe Ser Lys Tyr Asp Arg Lys Arg Asn Ser 
            180                 185                 190         


Pro Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Glu Leu Glu Lys Glu 
        195                 200                 205             


Ile Val Thr Leu Phe Ala Ala Gln Arg Arg Phe Gln Ser Pro Tyr Ala 
    210                 215                 220                 


Ser Lys Asp Leu Gln Glu Thr Tyr Leu Gln Ile Trp Thr His Gln Leu 
225                 230                 235                 240 


Pro Phe Ala Ser Gly Asn Ala Ile Leu Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     


Leu Leu Lys Gly Lys Glu Arg Arg Ile Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         


Gln Tyr Phe Ser Ala Leu Asp Gln Val Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             


Asp Phe Gln Pro Phe Thr Lys Glu Gln Arg Glu Ile Ile Leu Asn Asn 
    290                 295                 300                 


Met Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 


Thr Tyr Tyr Asp Ile Arg Lys Trp Leu Glu Leu Asp Glu Thr Ile Gln 
                325                 330                 335     


Phe Lys Gly Leu Asn Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         


Lys Lys Pro Phe Ile Asn Leu Lys Ala Phe Tyr Glu Ile Asn Lys Val 
        355                 360                 365             


Val Ala Asn Tyr Ser Glu Arg Thr Asn Glu Thr Phe Ser Thr Leu Asp 
    370                 375                 380                 


Tyr Asp Gly Ile Gly Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 


Ile Arg Ser Tyr Leu Lys Ser Ser His Asn Leu Pro Lys Arg Cys Tyr 
                405                 410                 415     


Asp Asp Gln Leu Ile Glu Glu Leu Leu Ser Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         


Gly His Leu Ser Leu Lys Ala Ile Asn His Val Leu Ser Ile Met Gln 
        435                 440                 445             


Lys Gly Asn Thr Tyr Lys Glu Ala Val Asp Gln Leu Gly Tyr Asp Thr 
    450                 455                 460                 


Ser Gly Leu Lys Lys Glu Lys Arg Ser Lys Phe Leu Pro Pro Ile Ser 
465                 470                 475                 480 


Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Leu Thr Gln Ala Arg 
                485                 490                 495     


Lys Val Val Asn Ala Ile Ile Arg Arg His Gly Ser Pro His Ser Val 
            500                 505                 510         


His Ile Glu Leu Ala Arg Glu Leu Ser Lys Asn His Asp Glu Arg Thr 
        515                 520                 525             


Lys Ile Val Ser Ala Gln Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 


Ile Ser Ile Leu Ser Glu His Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 


Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr 
                565                 570                 575     


Ser Leu Lys Glu Ile Pro Ala Asp Thr Phe Phe Asn Glu Leu Lys Lys 
            580                 585                 590         


Glu Arg Asn Gly Ala Pro Ile Leu Glu Val Asp His Ile Leu Pro Tyr 
        595                 600                 605             


Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Ser 
    610                 615                 620                 


Asp Glu Asn Arg Lys Lys Gly Asn Arg Ile Pro Tyr Thr Tyr Phe Leu 
625                 630                 635                 640 


Glu Thr Asn Lys Asp Trp Glu Ala Phe Glu Arg Tyr Val Arg Ser Asn 
                645                 650                 655     


Lys Phe Phe Ser Lys Lys Lys Arg Glu Tyr Leu Leu Lys Arg Ala Tyr 
            660                 665                 670         


Leu Pro Arg Glu Ser Glu Leu Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             


Arg Tyr Ala Ser Thr Phe Leu Lys Asn Phe Ile Glu Gln Asn Leu Gln 
    690                 695                 700                 


Phe Lys Glu Ala Glu Asp Asn Pro Arg Lys Arg Arg Val Gln Thr Val 
705                 710                 715                 720 


Asn Gly Val Ile Thr Ala His Phe Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     


Asp Arg Gln Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         


Ala Cys Thr Asp His His Met Val Thr Arg Val Thr Glu Tyr Tyr Gln 
        755                 760                 765             


Ile Lys Glu Ser Asn Lys Ser Val Lys Lys Pro Tyr Phe Pro Met Pro 
    770                 775                 780                 


Trp Glu Gly Phe Arg Asp Glu Leu Leu Ser His Leu Ala Ser Gln Pro 
785                 790                 795                 800 


Ile Ala Lys Lys Ile Ser Glu Glu Leu Lys Ala Gly Tyr Gln Ser Leu 
                805                 810                 815     


Asp Tyr Ile Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Ala 
            820                 825                 830         


Ala His Lys Gln Thr Ile Met Arg Lys Gly Gly Ile Asp Lys Lys Gly 
        835                 840                 845             


Lys Thr Ile Ile Ile Glu Arg Leu His Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 


Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Met Ala Thr 
865                 870                 875                 880 


Tyr Glu Ala Ile Lys Gln Arg Tyr Leu Glu His Gly Lys Asn Ser Lys 
                885                 890                 895     


Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Thr Gly 
            900                 905                 910         


Asn Leu Ile Lys Arg Val Lys Val Glu Gly Gln Ala Lys Ser Phe Val 
        915                 920                 925             


Arg Glu Val Asn Gly Gly Val Ala Gln Asn Gly Asp Leu Val Arg Val 
    930                 935                 940                 


Asp Leu Phe Glu Lys Asp Asp Lys Tyr Tyr Met Val Pro Ile Tyr Val 
945                 950                 955                 960 


Pro Asp Thr Val Cys Ser Glu Leu Pro Lys Lys Val Val Ala Ser Ser 
                965                 970                 975     


Lys Gly Tyr Glu Gln Trp Leu Thr Leu Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         


Phe Ser Leu Tyr Pro Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asp Glu 
        995                 1000                 1005             


Asp Arg  Phe Leu Tyr Phe Gly  Thr Leu Asp Ile Asp  Ser Asp Arg 
    1010                 1015                 1020             


Leu Asn  Phe Lys Asp Val Asn  Lys Pro Ser Lys Lys  Asn Glu Tyr 
    1025                 1030                 1035             


Arg Tyr  Ser Leu Lys Thr Ile  Glu Asp Leu Glu Lys  Tyr Glu Val 
    1040                 1045                 1050             


Gly Val  Leu Gly Asp Leu Arg  Leu Val Arg Lys Glu  Thr Arg Arg 
    1055                 1060                 1065             


Asn Phe  His 
    1070     


<210> 12
<211> 21
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="crRNA"

<400> 12
gucauaguuc cauuaaagcc a                                                 21


<210> 13
<211> 85
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 13
uggcuuugau guuucuauga uaaggguuuc gacccguggc gucggggauc gccugcccau       60

ugaaaugggc uucuccccau uuauu                                             85


<210> 14
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 14
gagcggacag cagcuuccua uaucucguac gucauaguuc cauuaaagcc agaaauggcu       60

uugauguuuc uaugauaagg guuucgaccc guggcgucgg ggaucgccug cccauugaaa      120

ugggcuucuc cccauuuauu                                                  140


<210> 15
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 15
ccaugauaua gacguugugg cuguuguagu gucauaguuc cauuaaagcc agaaauggcu       60

uugauguuuc uaugauaagg guuucgaccc guggcgucgg ggaucgccug cccauugaaa      120

ugggcuucuc cccauuuauu                                                  140


<210> 16
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 16
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 17
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 17
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 18
<211> 135
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 18
nnnnnnnnnn nnnnnnnnnn nnnnngucau aguuccauua aagccaaaag uggcuuugau       60

guuucuauga uaaggguuuc gacccguggc gucggggauc gccugcccau ugaaaugggc      120

uucuccccau uuauu                                                       135


<210> 19
<211> 1071
<212> PRT
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG07513.1"

<400> 19
Met Arg Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Gly Val Ile Glu Leu Ser Trp Asn Lys Asp Arg Glu Gln 
            20                  25                  30          


Tyr Glu Lys Thr Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys 
        35                  40                  45              


Ala Glu Ile Pro Lys Thr Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile 
    50                  55                  60                  


Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  


Asp Ile Arg Asn Leu Leu Val Gln His Glu Ile Ile Ser Gln Lys Glu 
                85                  90                  95      


Leu Thr Ser Leu Tyr Pro Leu Ser Lys Ser Ser Met Asp Ile Trp Asp 
            100                 105                 110         


Ile Arg Leu Asp Gly Leu Asp Arg Leu Leu Asp Arg Phe Glu Trp Ala 
        115                 120                 125             


Arg Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 


Lys Ser Glu Leu Lys Asp Val Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 


Gln Val Asn Glu Lys Arg Leu Ser Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     


Trp Met Lys Asn Ala Asp Cys Ser Lys Tyr Gly Lys Arg Arg Asn Ser 
            180                 185                 190         


Pro Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu 
        195                 200                 205             


Ile Val Thr Leu Phe Glu Ala Gln Arg Lys Phe His Ser Ser Tyr Ala 
    210                 215                 220                 


Ser Val Asp Leu Gln Lys Thr Tyr Ile Gln Ile Trp Ala His Gln Leu 
225                 230                 235                 240 


Pro Phe Ala Ser Gly Asn Ala Ile Val Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     


Leu Leu Lys Gly Lys Glu Lys Arg Val Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         


Gln Tyr Phe Asn Thr Leu Asp Gln Ile Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             


Asn Phe Gln Pro Phe Thr Lys Glu Gln Arg Asp Ile Ile Leu Asp Lys 
    290                 295                 300                 


Met Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 


Thr Tyr Tyr Asp Ile Arg Lys Trp Leu Ala Leu Asp Glu Thr Ile Gln 
                325                 330                 335     


Phe Lys Gly Leu Thr Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         


Met Lys Pro Phe Ile Asn Leu Lys Pro Phe Tyr Glu Ile Lys Lys Val 
        355                 360                 365             


Val Thr Asn Tyr Ala Lys Lys Thr Asn Glu Val Phe Ser Ala Leu Asp 
    370                 375                 380                 


Tyr Asp Thr Val Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 


Ile Arg Ser Tyr Leu Lys Arg Ser Asn Asn Leu Ser Lys Arg Cys Tyr 
                405                 410                 415     


Asp Asp Gln Leu Ile Glu Glu Leu Leu Thr Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         


Gly His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln 
        435                 440                 445             


Glu Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Thr 
    450                 455                 460                 


Thr Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Ile Ile Pro 
465                 470                 475                 480 


Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Leu Thr Gln Ala Arg 
                485                 490                 495     


Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val 
            500                 505                 510         


His Ile Glu Leu Ala Arg Glu Leu Ser Lys Ser His Asp Glu Arg Lys 
        515                 520                 525             


Lys Ile Met Thr Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 


Val Ser Ile Leu Ile Asp Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 


Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr 
                565                 570                 575     


Ser Leu Lys Lys Ile Pro Ala Asn Thr Phe Phe Asn Glu Leu Lys Lys 
            580                 585                 590         


Glu Arg Ser Gly Pro Pro Val Leu Glu Val Asp His Ile Leu Pro Tyr 
        595                 600                 605             


Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Gly 
    610                 615                 620                 


Asp Glu Asn Gln Lys Lys Gly Asn Arg Ile Pro Tyr Thr Phe Phe Ser 
625                 630                 635                 640 


Glu Glu Asp Lys Glu Trp Glu Ser Phe Glu Ser Tyr Val Arg Ser Asn 
                645                 650                 655     


Ser Phe Phe Ser Lys Lys Lys Arg Gly Tyr Leu Leu Lys Lys Ala Tyr 
            660                 665                 670         


Leu Pro Arg Glu Ser Asn Leu Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             


Arg Tyr Ala Ser Ser Tyr Leu Lys Asn Phe Ile Glu Lys Asn Leu Lys 
    690                 695                 700                 


Phe Lys Glu Ala Val Gly Ile Thr Arg Lys Lys Tyr Val Gln Thr Val 
705                 710                 715                 720 


Asn Gly Val Ile Thr Ala His Leu Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     


Asp Arg Gln Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         


Ala Cys Thr Asp His His Met Val Thr Lys Val Thr Glu Tyr Tyr Gln 
        755                 760                 765             


Ile Lys Glu Gly Asn Lys Ser Ile Lys Lys Pro Tyr Phe Pro Leu Pro 
    770                 775                 780                 


Trp Met Gly Phe Arg Glu Glu Ile Leu Ser His Leu Glu Ser Gln Pro 
785                 790                 795                 800 


Ile Ala Arg Lys Ile Ser Glu Glu Leu Lys Ile Gly Tyr Gln Ser Pro 
                805                 810                 815     


Asp Tyr Ile Leu Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ser 
            820                 825                 830         


Ala His Asp Gln Thr Val Met Lys Lys Gly Asp Ile Asp Lys Lys Gly 
        835                 840                 845             


Lys Thr Ile Ile Ile Lys Arg Val His Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 


Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Leu Ala Thr 
865                 870                 875                 880 


Tyr Glu Ala Ile Lys Gln Arg Tyr Leu Glu Tyr Arg Lys Glu Ser Lys 
                885                 890                 895     


Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Lys Gly 
            900                 905                 910         


Asn Leu Ile Lys Lys Ile Lys Val Glu Val Gln Thr Lys Ser Phe Val 
        915                 920                 925             


Arg Glu Ile Asn Gly Gly Val Ala Gln Asn Gly Asp Leu Val Arg Val 
    930                 935                 940                 


Asp Leu Phe Glu Lys Asp Asn Arg Tyr Tyr Met Val Pro Ile Tyr Val 
945                 950                 955                 960 


Val Asp Thr Val Arg Ser Glu Leu Pro Asn Lys Ala Val Thr Ser Ser 
                965                 970                 975     


Lys Gly Tyr Glu Gln Trp Leu Ser Ile Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         


Phe Ser Leu Tyr Pro Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asp Glu 
        995                 1000                 1005             


Asp Arg  Phe Leu Tyr Phe Ser  Thr Leu Asp Ile Asn  Ser Asp Arg 
    1010                 1015                 1020             


Leu Asn  Phe Lys Asp Val Asn  Lys Pro Ser Lys Gln  Ala Glu Tyr 
    1025                 1030                 1035             


Arg Tyr  Ser Leu Lys Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Ile 
    1040                 1045                 1050             


Gly Val  Leu Gly Asp Leu Arg  Leu Val Arg Gln Glu  Thr Arg Lys 
    1055                 1060                 1065             


Ile Phe  Lys 
    1070     


<210> 20
<211> 27
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="crRNA"

<400> 20
gucauaguuc cauuaaagcc auugcug                                           27


<210> 21
<211> 93
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 21
acagcaaugg cuuugauguu ucuaugauaa gggcuucggc ccguggcguu ggggaucgcc       60

ugcccauuuu aaugggcuuc uccccaucua uuu                                    93


<210> 22
<211> 154
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 22
gagcggacag cagcuuccua uaucucguac gucauaguuc cauuaaagcc auugcugaaa       60

gacagcaaug gcuuugaugu uucuaugaua agggcuucgg cccguggcgu uggggaucgc      120

cugcccauuu uaaugggcuu cuccccaucu auuu                                  154


<210> 23
<211> 154
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 23
ccaugauaua gacguugugg cuguuguagu gucauaguuc cauuaaagcc auugcugaaa       60

gacagcaaug gcuuugaugu uucuaugaua agggcuucgg cccguggcgu uggggaucgc      120

cugcccauuu uaaugggcuu cuccccaucu auuu                                  154


<210> 24
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 24
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 25
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 25
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 26
<211> 149
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 26
nnnnnnnnnn nnnnnnnnnn nnnnngucau aguuccauua aagccauugc ugaaagacag       60

caauggcuuu gauguuucua ugauaagggc uucggcccgu ggcguugggg aucgccugcc      120

cauuuuaaug ggcuucuccc caucuauuu                                        149


<210> 27
<211> 1072
<212> PRT
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG08290.1"

<400> 27
Met Ser Glu Leu Asp Tyr Arg Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Gly Val Ile Glu Leu Phe Trp Asn Lys Asp Arg Glu Arg 
            20                  25                  30          


Tyr Glu Lys Val Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys 
        35                  40                  45              


Ala Glu Ile Pro Asn Lys Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile 
    50                  55                  60                  


Ala Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys 
65                  70                  75                  80  


Glu Ile Arg Asn Leu Leu Val Gln His Gly Met Ile Thr Gln Glu Glu 
                85                  90                  95      


Leu Asp Leu Leu Tyr Pro Leu Ser Lys Lys Ser Ile Asp Ile Trp Asp 
            100                 105                 110         


Ile Arg Leu Asp Gly Leu Asp Arg Leu Leu Asn His Leu Glu Trp Ala 
        115                 120                 125             


Arg Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 


Lys Ser Glu Leu Lys Asp Ala Glu Thr Gly Lys Val Leu Ser Ser Ile 
145                 150                 155                 160 


Gln Val Asn Glu Lys Arg Leu Phe Leu Tyr Arg Thr Val Gly Glu Met 
                165                 170                 175     


Trp Ile Lys Asp Ala Glu Phe Ser Lys Tyr Asp Arg Arg Arg Asn Ser 
            180                 185                 190         


Pro Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu 
        195                 200                 205             


Ile Val Thr Leu Phe Glu Ala Gln Arg Lys Phe Gln Ser Ser Tyr Ala 
    210                 215                 220                 


Ser Lys Asn Leu Gln Glu Thr Tyr Leu Gln Ile Trp Ala His Gln Leu 
225                 230                 235                 240 


Pro Phe Ala Ser Gly Asn Ala Ile Leu Asn Lys Val Gly Tyr Cys Ser 
                245                 250                 255     


Leu Leu Lys Gly Lys Glu Arg Arg Ile Pro Lys Ala Thr Tyr Thr Phe 
            260                 265                 270         


Gln Tyr Phe Ser Ala Leu Asp Gln Val Asn Arg Thr Arg Leu Gly Pro 
        275                 280                 285             


Asp Phe Gln Pro Phe Thr Gln Glu Gln Lys Glu Ile Ile Leu Asp Lys 
    290                 295                 300                 


Met Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val 
305                 310                 315                 320 


Ser Tyr Tyr Asp Ile Arg Lys Trp Leu Glu Leu Asp Glu Thr Ile Gln 
                325                 330                 335     


Phe Lys Gly Leu Asn Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu 
            340                 345                 350         


Lys Lys Pro Phe Ile Asn Leu Lys Ala Phe Tyr Glu Ile Lys Lys Val 
        355                 360                 365             


Val Ala Asn Tyr Ala Glu Arg Thr Asn Glu Ala Phe Ser Thr Leu Asp 
    370                 375                 380                 


Tyr Asp Ala Ile Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp 
385                 390                 395                 400 


Ile Arg Ser Tyr Leu Lys Lys Ser Asn Asn Leu Ser Lys Arg Cys Tyr 
                405                 410                 415     


Asp Asp Gln Leu Ile Glu Glu Leu Phe Thr Leu Ser Tyr Thr Lys Phe 
            420                 425                 430         


Gly His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln 
        435                 440                 445             


Glu Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Thr 
    450                 455                 460                 


Thr Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Ile Pro 
465                 470                 475                 480 


Asp Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Ile Thr Gln Ala Arg 
                485                 490                 495     


Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val 
            500                 505                 510         


His Ile Glu Leu Ala Arg Glu Leu Ser Lys Ser His Asp Glu Arg Lys 
        515                 520                 525             


Lys Ile Met Thr Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala 
    530                 535                 540                 


Ile Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp 
545                 550                 555                 560 


Ile Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr 
                565                 570                 575     


Ser Leu Lys Glu Ile Pro Pro Asp Thr Phe Phe Asn Glu Leu Lys Lys 
            580                 585                 590         


Glu Arg Asn Gly Ser Pro Ile Leu Glu Val Asp His Ile Leu Pro Tyr 
        595                 600                 605             


Ser Gln Ser Phe Ile Asp Ser Tyr His Asn Lys Val Leu Val Tyr Ser 
    610                 615                 620                 


Asp Glu Asn Arg Asn Lys Gly Asn Arg Ile Pro Tyr Thr Tyr Phe Leu 
625                 630                 635                 640 


Glu Thr Asn Lys Asp Trp Glu Ala Phe Glu Arg Tyr Val Arg Ser Asn 
                645                 650                 655     


Lys Leu Phe Ser Lys Lys Lys Arg Glu Tyr Leu Leu Lys Lys Thr Tyr 
            660                 665                 670         


Leu Pro Arg Glu Ser Glu Leu Ile Lys Glu Arg His Leu Asn Asp Thr 
        675                 680                 685             


Arg Tyr Ala Ser Thr Phe Leu Lys Asn Phe Ile Glu Gln Asn Leu Gln 
    690                 695                 700                 


Phe Lys Glu Val Glu Val Asn Leu Arg Lys Lys Arg Val Gln Thr Val 
705                 710                 715                 720 


Asn Gly Val Ile Thr Ala His Leu Arg Lys Arg Trp Gly Leu Glu Lys 
                725                 730                 735     


Asn Arg Gln Glu Thr Tyr Leu His His Ala Met Asp Ala Ile Ile Val 
            740                 745                 750         


Ala Cys Thr Asp His His Met Val Thr Arg Ile Thr Glu Tyr Tyr Gln 
        755                 760                 765             


Ile Lys Glu Ser Asn Lys Ser Val Lys Lys Pro Tyr Phe Pro Met Pro 
    770                 775                 780                 


Trp Glu Gly Phe Arg Asp Glu Leu Leu Ser His Leu Ala Ser Gln Pro 
785                 790                 795                 800 


Ile Ala Lys Lys Ile Ser Glu Glu Leu Lys Ala Gly Tyr Gln Ser Ser 
                805                 810                 815     


Asp Tyr Ile Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala 
            820                 825                 830         


Ala His Asp Gln Thr Ile Arg Arg Lys Gly Gly Ile Asp Lys Lys Gly 
        835                 840                 845             


Lys Thr Ile Ile Ile Lys Arg Val Arg Leu Lys Asp Ile Lys Phe Asp 
    850                 855                 860                 


Glu Asn Gly Asp Phe Lys Met Val Gly Lys Glu Gln Asp Leu Ala Thr 
865                 870                 875                 880 


Tyr Glu Ala Ile Lys Gln Arg Tyr Leu Glu His Arg Lys Asn Ser Lys 
                885                 890                 895     


Lys Ala Phe Glu Thr Pro Leu Tyr Lys Pro Ser Lys Lys Gly Thr Gly 
            900                 905                 910         


Asn Leu Ile Lys Arg Val Lys Ile Glu Gly Gln Thr Lys Ala Phe Val 
        915                 920                 925             


Arg Glu Val Asn Gly Gly Val Ala Gln Asn Ser Asp Leu Val Arg Val 
    930                 935                 940                 


Asp Leu Phe Glu Lys Asp Asp Lys Tyr Tyr Met Val Pro Ile Tyr Val 
945                 950                 955                 960 


Pro Asp Thr Val Cys Ser Glu Leu Pro Lys Lys Val Val Lys Ser Gly 
                965                 970                 975     


Lys Gly Tyr Glu Gln Trp Leu Thr Leu Asp Asn Ser Phe Thr Phe Lys 
            980                 985                 990         


Ser Ser Leu Tyr Pro Tyr Asp Leu  Val Arg Leu Val Lys  Gly Asn Glu 
        995                 1000                 1005             


Asp Arg  Phe Leu Tyr Phe Gly  Thr Leu Asp Ile Asp  Ser Asp Arg 
    1010                 1015                 1020             


Leu Asn  Phe Lys Asp Val Asn  Lys Pro Ser Lys Gln  Asn Glu Tyr 
    1025                 1030                 1035             


Arg Tyr  Ser Leu Lys Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val 
    1040                 1045                 1050             


Gly Val  Leu Gly Asp Leu Arg  Leu Val Lys Gln Glu  Thr Arg Arg 
    1055                 1060                 1065             


Ile Phe  Asn Arg 
    1070         


<210> 28
<211> 21
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="crRNA"

<400> 28
gucauaguuc caugaaagcc a                                                 21


<210> 29
<211> 85
<212> RNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 29
uggcuuugau guuucuauga uaaggguuuc ggcccguggc gucggggauc gccugcccau       60

uccgaugggc uucuccccau uuauu                                             85


<210> 30
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 30
gagcggacag cagcuuccua uaucucguac gucauaguuc caugaaagcc aaaaguggcu       60

uugauguuuc uaugauaagg guuucggccc guggcgucgg ggaucgccug cccauuccga      120

ugggcuucuc cccauuuauu                                                  140


<210> 31
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 31
ccaugauaua gacguugugg cuguuguagu gucauaguuc caugaaagcc aaaaguggcu       60

uugauguuuc uaugauaagg guuucggccc guggcgucgg ggaucgccug cccauuccga      120

ugggcuucuc cccauuuauu                                                  140


<210> 32
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PAM"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 32
nnrncc                                                                   6


<210> 33
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 33
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 34
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 34
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 35
<211> 135
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 35
nnnnnnnnnn nnnnnnnnnn nnnnngucau aguuccauga aagccaaaag uggcuuugau       60

guuucuauga uaaggguuuc ggcccguggc gucggggauc gccugcccau uccgaugggc      120

uucuccccau uuauu                                                       135


<210> 36
<211> 1337
<212> PRT
<213> Enterococcus sp.

<220>
<221> source
<223> /note="APG05459.1"

<400> 36
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Thr Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Met Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Met Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Asn Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 37
<211> 16
<212> RNA
<213> Enterococcus sp.

<220>
<221> source
<223> /note="crRNA"

<400> 37
guuuuagagu cauguu                                                       16


<210> 38
<211> 74
<212> RNA
<213> Enterococcus sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 38
aacauagcaa guuaaaauaa gguuuuaacc guaaucaacu guaaaguggc gcuguuucgg       60

cgcuuuuuuu guuu                                                         74


<210> 39
<211> 124
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 39
gagcggacag cagcuuccua uaucucguac guuuuagagu cauguuaaag aacauagcaa       60

guuaaaauaa gguuuuaacc guaaucaacu guaaaguggc gcuguuucgg cgcuuuuuuu      120

guuu                                                                   124


<210> 40
<211> 124
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 40
ccaugauaua gacguugugg cuguuguagu guuuuagagu cauguuaaag aacauagcaa       60

guuaaaauaa gguuuuaacc guaaucaacu guaaaguggc gcuguuucgg cgcuuuuuuu      120

guuu                                                                   124


<210> 41
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PAM"


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 41
ngg                                                                      3


<210> 42
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 42
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 43
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 43
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 44
<211> 119
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 44
nnnnnnnnnn nnnnnnnnnn nnnnnguuuu agagucaugu uaaagaacau agcaaguuaa       60

aauaagguuu uaaccguaau caacuguaaa guggcgcugu uucggcgcuu uuuuuguuu       119


<210> 45
<211> 1436
<212> PRT
<213> Enterococcus sp.

<220>
<221> source
<223> /note="APG04583.1"

<400> 45
Met Ala Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Trp Ala Leu Val Gln Gln Asp Phe Glu Asn Lys Glu Gly Asn Ile Leu 
            20                  25                  30          


Gly Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Glu 
        35                  40                  45              


Phe Gly Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Gly Tyr 
    50                  55                  60                  


Arg Gly Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Val Leu His Leu Leu Gly Phe Leu Pro Lys His Tyr Asp 
                85                  90                  95      


Glu Lys Ile Asp Phe Thr Gln Arg Phe Gly Lys Phe Ile Asn Gln Ala 
            100                 105                 110         


Glu Pro Lys Leu Ala Phe Asp Ser Glu Phe Leu Phe Lys Asp Ser Phe 
        115                 120                 125             


His Glu Met Leu Ala Asp Phe Lys Gln Asn Gln Pro Glu Phe Leu Lys 
    130                 135                 140                 


Asp Lys Asn Gly Glu Asp Cys Leu Val Pro Tyr Asp Trp Thr Ile Tyr 
145                 150                 155                 160 


Tyr Leu Arg Lys Lys Ala Leu Thr Gln Lys Ile Glu Lys Tyr Glu Leu 
                165                 170                 175     


Ala Trp Leu Ile Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu 
            180                 185                 190         


Arg Gly Glu Glu Glu Lys Glu Asn Pro Asn Lys Leu Val Gly Phe His 
        195                 200                 205             


Ser Leu Lys Ile Val Asp Val Ile Pro Asp Ala Glu Thr Asn Lys Lys 
    210                 215                 220                 


Gly Glu Thr Trp Tyr Ser Leu His Leu Glu Asn Gly Trp Val Tyr Arg 
225                 230                 235                 240 


Arg Ser Ser Lys Ile Ser Leu Ala Asp Trp Lys Asp Lys Val Arg Asp 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Ser Glu Lys Leu Asp 
            260                 265                 270         


Lys Asp Gly Ile Val Lys Arg Ser Phe Arg Ala Pro Ser Ala Asp Asp 
        275                 280                 285             


Trp Thr Leu Leu Lys Lys Lys Thr Glu Lys Asp Ile Asp Asn Ser Asn 
    290                 295                 300                 


Lys Thr Val Gly Thr Tyr Ile Tyr Asp Asn Leu Leu Leu Asn Pro Lys 
305                 310                 315                 320 


Gln Lys Ile Lys Gly Lys Met Val Arg Thr Ile Glu Arg Lys Phe Tyr 
                325                 330                 335     


Lys Gln Glu Leu Glu Gln Ile Leu Lys Thr Gln Lys Glu Phe His Ser 
            340                 345                 350         


Glu Leu Gln Ser Glu Asn Leu Leu Gln Asp Cys Val Arg Glu Leu Tyr 
        355                 360                 365             


Arg Asn Asn Glu Gln His Gln Gln Met Leu Glu Ala Lys Asp Phe Val 
    370                 375                 380                 


His Leu Phe Leu Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser 
385                 390                 395                 400 


Gln Lys Ser Ser Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Ser Lys 
                405                 410                 415     


Asn Glu Asn Gly Glu Glu Val Ile His Arg Leu Lys Val Ile Ala Lys 
            420                 425                 430         


Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Leu Leu Gln Trp Val Gln Asn 
        435                 440                 445             


Leu Ala Ile Tyr Thr Lys Asp Asp Asp Lys Asn Val Thr Asn Glu Phe 
    450                 455                 460                 


Leu Lys Ser Thr Gln Asp Trp Glu Asp Leu Leu Arg Trp Leu His Ser 
465                 470                 475                 480 


Lys Lys Glu Ile Lys Gln Asp Ala Leu Ile Lys Phe Leu Ile Glu Lys 
                485                 490                 495     


Lys Gly Leu Lys Gly Lys Ala Leu Thr Ile Glu Val Ala Lys Tyr Arg 
            500                 505                 510         


Trp Asn Tyr Val Gln Asp Lys Asp Tyr Pro Gly Asn Glu Thr Arg Tyr 
        515                 520                 525             


Leu Ile Gln Ser Arg Leu Asp Lys Val Glu Tyr Ala Pro Lys Asp Phe 
    530                 535                 540                 


Leu Thr Tyr Glu Asn Glu Met Ala Leu Trp His Ile Ile Tyr Ser Ile 
545                 550                 555                 560 


Asn Asp Lys Ile Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Asn Lys 
                565                 570                 575     


Lys Gly Leu Asp Glu Val Thr Phe Val Glu Ala Phe Lys Lys Phe Pro 
            580                 585                 590         


Pro Phe Lys Ser Asp Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys 
        595                 600                 605             


Leu Leu Pro Leu Met Arg Phe Gly Thr Gln Trp Asn Trp Asp Asn Ile 
    610                 615                 620                 


Asp Gln Asn Ser Lys Glu Arg Ile Gly Lys Ile Leu Thr Gly Glu Tyr 
625                 630                 635                 640 


Asp Glu Asn Ile Lys Gly Arg Val Arg Glu Lys Ala Arg His Leu Asn 
                645                 650                 655     


Ser Glu Thr Asp Phe Gln Ala Leu Pro Leu Trp Leu Ala Gln Tyr Val 
            660                 665                 670         


Val Tyr Gly Arg His Ser Glu Ala Asp Ile Ala Gly Lys Trp Asn Ser 
        675                 680                 685             


Val Asp Asp Leu Lys Gln Phe Leu Asp Asp Phe Lys Gln His Ser Leu 
    690                 695                 700                 


Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Ala Val 
705                 710                 715                 720 


Lys Asp Ile Trp Asn Phe Tyr Gly Lys Gly Ala Lys Asp Phe Phe Ser 
                725                 730                 735     


Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Asp Glu 
            740                 745                 750         


Arg Lys Arg Ile Thr Thr Met Val Thr Asp Asn Glu Asn Thr Asn Leu 
        755                 760                 765             


Arg Ile Lys Ala Leu Leu Ala Glu Met Ala Leu Asp Gln Asn Val Asp 
    770                 775                 780                 


Asn Val Arg Pro Tyr Ser Pro Met Gln Gln Glu Ile Leu Lys Ile Tyr 
785                 790                 795                 800 


Glu Glu Gly Val Leu Asn Ala Glu Glu Asn Ile Asp Asp Asp Ile Leu 
                805                 810                 815     


Lys Ile Ser Lys Thr Ala Gln Pro Ser Ala Thr Asp Leu Lys Arg Tyr 
            820                 825                 830         


Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Gln Met 
        835                 840                 845             


Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His Ile 
    850                 855                 860                 


Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Met Ser Asn Lys Val Ile 
865                 870                 875                 880 


Cys Glu Ala Ala Val Asn Lys Leu Lys Asp Asn Gln Ile Gly Leu Val 
                885                 890                 895     


Phe Ile Lys Asn His His Gly Glu Val Val Asp Phe Gly Met Gly Lys 
            900                 905                 910         


Gln Val Lys Ile Leu Glu Val Ser Asp Tyr Glu Asp Phe Val Lys Gln 
        915                 920                 925             


Asn Tyr Asn Lys Asn Arg Gly Lys Arg Asn Lys Leu Leu Leu Glu Asp 
    930                 935                 940                 


Ile Pro Glu Lys Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile 
945                 950                 955                 960 


Ser Lys Tyr Ile Thr Gln Val Leu Ser Asn Ile Val Arg Asp Asp Lys 
                965                 970                 975     


Glu Gly Ser Lys Asp Asp Gly Val Asn Ser Lys Asn Ile Val Pro Gly 
            980                 985                 990         


Asn Gly Lys Ile Thr Thr Arg Leu  Lys Gln Asp Trp Gly  Leu Asn Asp 
        995                 1000                 1005             


Val Trp  Asn Asp Leu Val Leu  Pro Arg Phe Glu Arg  Met Asn Thr 
    1010                 1015                 1020             


Leu Thr  Asn Ser Asn Asp Phe  Thr Ser Lys Asn Thr  His Gly Lys 
    1025                 1030                 1035             


Thr Ile  Pro Thr Val Pro Ile  Glu Leu Ser Lys Gly  Phe Ser Lys 
    1040                 1045                 1050             


Lys Arg  Ile Asp His Arg His  His Ala Met Asp Ala  Leu Val Ile 
    1055                 1060                 1065             


Ala Cys  Ala Thr Arg Asp His  Val Asn Leu Leu Asn  Asn Glu Ser 
    1070                 1075                 1080             


Ser Lys  Ser Asp Thr Lys Arg  Tyr Asp Leu Asn Arg  Lys Leu Arg 
    1085                 1090                 1095             


Lys Tyr  Glu Lys Val Ala Tyr  Asn Asp Pro Lys Thr  Gly Glu Arg 
    1100                 1105                 1110             


Ile Glu  Lys Glu Val Pro Lys  Asp Phe Ile Lys Pro  Trp Glu Thr 
    1115                 1120                 1125             


Phe Thr  Glu Asp Thr Arg Thr  Leu Leu Glu Asn Ile  Val Ile Ser 
    1130                 1135                 1140             


Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys Ala Thr  Asn Tyr Tyr 
    1145                 1150                 1155             


Glu Lys  Ile Glu Asn Gly Lys  Lys Val Lys Val Glu  Gln Lys Gly 
    1160                 1165                 1170             


Ile Asn  Trp Ala Val Arg Lys  Ala Leu His Lys Glu  Thr Val Ser 
    1175                 1180                 1185             


Gly Gln  Val His Leu Asp Arg  Ile Lys Val Ala Lys  Gly Lys Ile 
    1190                 1195                 1200             


Leu Thr  Ala Thr Arg Lys Thr  Leu Asp Ala Ser Phe  Asn Glu Lys 
    1205                 1210                 1215             


Thr Ile  Glu Ser Ile Thr Asp  Thr Gly Ile Gln Lys  Ile Leu Leu 
    1220                 1225                 1230             


Asn Tyr  Leu Lys Ser Lys Asp  Asn Asn Pro Glu Val  Ala Phe Ser 
    1235                 1240                 1245             


Pro Glu  Gly Ile Glu Glu Leu  Asn Lys Asn Ile Arg  Leu Tyr Asn 
    1250                 1255                 1260             


Asp Gly  Lys Ala His Gln Pro  Ile Leu Lys Val Arg  Val Phe Glu 
    1265                 1270                 1275             


Gln Gly  Ser Lys Phe Thr Leu  Gly Glu Thr Gly Asn  Lys Thr Thr 
    1280                 1285                 1290             


Lys Phe  Val Glu Ala Ala Lys  Gly Thr Asn Leu Phe  Phe Gly Ile 
    1295                 1300                 1305             


Tyr Glu  Asp Lys Ser Gly Lys  Arg Ser Tyr Glu Thr  Ile Pro Leu 
    1310                 1315                 1320             


Asn Ile  Val Ile Glu Arg Gln  Lys Gln Gly Leu Gln  Ala Val Pro 
    1325                 1330                 1335             


Glu Thr  Asn Glu Lys Gly Lys  Gln Leu Leu Phe Thr  Leu Ser Pro 
    1340                 1345                 1350             


Asn Asp  Leu Val Tyr Val Pro  Glu Glu Gly Val Phe  Asp Glu Asn 
    1355                 1360                 1365             


Asn Ile  Lys Val Asp Arg Ile  Tyr Lys Val Val Ser  Phe Ser Thr 
    1370                 1375                 1380             


Tyr Gln  Cys Phe Phe Val Arg  Asn Asp Val Ser Thr  Ser Val Val 
    1385                 1390                 1395             


Asn Lys  Val Glu Tyr Ser Ala  Leu Asn Lys Met Glu  Lys Ser Ile 
    1400                 1405                 1410             


Asp Asn  Ile Met Ile Lys Glu  Asn Cys Val Lys Leu  Asn Val Asp 
    1415                 1420                 1425             


Arg Leu  Gly Lys Ile Ser Lys  Ala 
    1430                 1435     


<210> 46
<211> 16
<212> RNA
<213> Enterococcus sp.

<220>
<221> source
<223> /note="crRNA"

<400> 46
guugugaguu ccuuuc                                                       16


<210> 47
<211> 78
<212> RNA
<213> Enterococcus sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 47
gaaaggaacu cacaauaagg auuauuccgu ugugaaaaca uuuagcgccu cgacuaucuu       60

cggggcuuuu uuauuuuu                                                     78


<210> 48
<211> 128
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 48
gagcggacag cagcuuccua uaucucguac guugugaguu ccuuucacuu gaaaggaacu       60

cacaauaagg auuauuccgu ugugaaaaca uuuagcgccu cgacuaucuu cggggcuuuu      120

uuauuuuu                                                               128


<210> 49
<211> 128
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 49
ccaugauaua gacguugugg cuguuguagu guugugaguu ccuuucacuu gaaaggaacu       60

cacaauaagg auuauuccgu ugugaaaaca uuuagcgccu cgacuaucuu cggggcuuuu      120

uuauuuuu                                                               128


<210> 50
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PAM"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<400> 50
nnraaty                                                                  7


<210> 51
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 51
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 52
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 52
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 53
<211> 123
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 53
nnnnnnnnnn nnnnnnnnnn nnnnnguugu gaguuccuuu caaaggaaag gaacucacaa       60

uaaggauuau uccguuguga aaacauuuag cgccucgacu aucuucgggg cuuuuuuauu      120

uuu                                                                    123


<210> 54
<211> 1456
<212> PRT
<213> Empedobacter sp.

<220>
<221> source
<223> /note="APG01688.1"

<400> 54
Met Met Ile Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile 
1               5                   10                  15      


Gly Trp Ala Leu Ile Lys Gln Asp Phe Glu Asn Lys His Gly Glu Ile 
            20                  25                  30          


Leu Gly Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly 
        35                  40                  45              


Asp Phe Gly Lys Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Lys 
    50                  55                  60                  


Tyr Arg Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Arg Val Leu His Leu Leu Asn Phe Leu Pro Gln His Tyr 
                85                  90                  95      


Ala Ser Gln Ile Asp Phe Glu Lys Lys Phe Gly Lys Phe Lys Ser Glu 
            100                 105                 110         


Thr Glu Pro Lys Leu Ala Trp Glu Asn Trp Gly Gly Lys Phe Ser Phe 
        115                 120                 125             


Leu Phe Gln Asn Ser Phe Asn Glu Met Leu Glu Asp Phe Lys Ala Ala 
    130                 135                 140                 


Gly Gln Gly Leu Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg 
145                 150                 155                 160 


Lys Lys Ala Leu Ser Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp Ile 
                165                 170                 175     


Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu 
            180                 185                 190         


Glu Glu Glu Glu Asn Pro Asn Lys Leu Val Glu Phe Tyr Ser Leu Lys 
        195                 200                 205             


Ile Val Asp Val Val Ala Asp Glu Pro Gln Lys Gly Lys Ser Asp Ile 
    210                 215                 220                 


Trp Tyr Ser Leu Ile Leu Glu Asn Gly Trp Val Tyr Arg Arg Ala Ser 
225                 230                 235                 240 


Lys Ile Pro Leu Phe Asp Trp Lys Asp Lys Thr Arg Asp Phe Ile Val 
                245                 250                 255     


Thr Thr Asp Leu Asn Asp Asp Arg Ser Val Lys Thr Asp Lys Glu Gly 
            260                 265                 270         


Asn Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Asn Asp Trp Thr Leu 
        275                 280                 285             


Val Lys Lys Lys Thr Glu Gln Glu Ile Asp Gln Ser His Lys Thr Val 
    290                 295                 300                 


Gly Thr Tyr Ile Tyr Glu Thr Leu Leu Leu Asn Pro Lys Gln Lys Ile 
305                 310                 315                 320 


Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Asp Glu 
                325                 330                 335     


Leu Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Gln Glu Leu Lys 
            340                 345                 350         


Asn Asp Asp Leu Tyr Asn Asp Cys Ile Arg Glu Leu Tyr Arg Asn Asn 
        355                 360                 365             


Glu Ala His Gln Leu Thr Leu Ser Lys Lys Asp Phe Val His Leu Leu 
    370                 375                 380                 


Met Asp Asp Leu Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser 
385                 390                 395                 400 


Ser Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn 
                405                 410                 415     


Gly Ile Glu His Thr Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro 
            420                 425                 430         


Tyr Tyr Gln Glu Phe Arg Leu Trp Gln Trp Met Tyr Asn Leu Asn Ile 
        435                 440                 445             


Tyr Arg Lys Asp Asp Glu Ala Asn Val Thr Lys Glu Phe Leu Asn Thr 
    450                 455                 460                 


Asn Lys Asp Phe Glu Ser Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu 
465                 470                 475                 480 


Ile Glu Gln Lys Pro Leu Ile Lys Phe Leu Leu Glu Gln Lys Asp Ile 
                485                 490                 495     


Asn Lys Lys Leu Leu Asn Ala Glu Ala Glu Lys Tyr Arg Trp Asn Tyr 
            500                 505                 510         


Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys Thr Met Ile Ser 
        515                 520                 525             


Ser Arg Leu Asp Lys Val Glu Asn Ile Ser Asp Asp Phe Leu Thr Arg 
    530                 535                 540                 


Asp Ile Glu Gln Lys Ile Trp His Ile Ile Tyr Ser Val Asn Asp Lys 
545                 550                 555                 560 


Ile Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Thr Arg Asn Asp Leu 
                565                 570                 575     


Asp Glu Asn Ser Phe Ile Glu Ala Phe Lys Lys Phe Ser Pro Phe Lys 
            580                 585                 590         


Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 
        595                 600                 605             


Leu Met Arg Leu Gly Lys Tyr Trp Tyr Glu Asp Glu Ile Val Lys His 
    610                 615                 620                 


Ser Asp Ile Tyr Phe Lys Asn Ile Glu Asn Leu Leu Gly Asp Phe Ser 
625                 630                 635                 640 


Asn Arg Asp Lys Lys Ile Ser Glu Glu Asp Lys Glu Lys Trp Asn Lys 
                645                 650                 655     


Ser Ile Asn Leu Lys Leu Gln Glu Glu Leu Lys Asp Phe Gln Thr Ala 
            660                 665                 670         


Glu Ile Asp Leu Phe Gln Gly Leu Arg Leu His Ile Ala Gln Tyr Leu 
        675                 680                 685             


Val Tyr Gly Arg His Ser Glu Ala Ser Met Ile Gly Lys Trp Asn Ser 
    690                 695                 700                 


Ala Glu Asp Leu Glu Glu Phe Leu Lys Asp Phe Lys Gln His Ser Leu 
705                 710                 715                 720 


Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val 
                725                 730                 735     


Lys Asp Ile Trp Leu Lys Tyr Gly Asn Gly Ala Lys Asp Phe Phe Asn 
            740                 745                 750         


Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Asp Asp 
        755                 760                 765             


Arg Lys Lys Leu Thr Asn Gln Ile Ser Glu Asn Glu Asn Thr Asn Phe 
    770                 775                 780                 


Arg Ile Lys Ala Leu Leu Ala Glu Met Met Asn Asp Ser Ser Val Glu 
785                 790                 795                 800 


Asn Val Arg Pro Phe Ser Pro Met Gln Gln Glu Ile Leu Lys Ile Tyr 
                805                 810                 815     


Glu Asp Asp Val Leu Lys Ser Asp Ile Glu Ile Glu Asp Asp Ile Leu 
            820                 825                 830         


Lys Ile Ser Lys Thr Ala Gln Pro Ser Pro Ser Asp Leu Lys Arg Tyr 
        835                 840                 845             


Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln Ile 
    850                 855                 860                 


Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His Ile 
865                 870                 875                 880 


Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile 
                885                 890                 895     


Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu Glu 
            900                 905                 910         


Phe Ile Lys Gln Phe Gly Gly Thr Ile Ile Glu Leu Gly Phe Gly Lys 
        915                 920                 925             


Ser Ile Lys Val Phe Glu Thr Lys Glu Tyr Glu Asp Phe Val Lys Lys 
    930                 935                 940                 


His Tyr Ala Asn Asn Gln Gly Lys Arg Asn Lys Leu Leu Met Glu Asp 
945                 950                 955                 960 


Ile Pro Glu Lys Met Ile Glu Arg Gln Met Asn Asp Thr Arg Tyr Ile 
                965                 970                 975     


Ser Lys Tyr Ile Ser Gly Val Leu Ser Asn Ile Val Arg Val Glu Asp 
            980                 985                 990         


Gly Ser Asp Glu Gly Val Asn Ser  Lys Asn Ile Val Pro  Gly Asn Gly 
        995                 1000                 1005             


Lys Ile  Thr Thr Gln Leu Lys  Gln Asp Trp Gly Leu  Asn Asp Val 
    1010                 1015                 1020             


Trp Asn  Asp Leu Ile Leu Pro  Arg Phe Glu Arg Met  Asn Gln Leu 
    1025                 1030                 1035             


Thr Asn  Ser Lys Val Phe Thr  Ala Trp Asn Glu Asn  Tyr Gln Lys 
    1040                 1045                 1050             


Phe Leu  Pro Thr Val Pro Ile  Glu Tyr Ser Lys Gly  Phe Ser Lys 
    1055                 1060                 1065             


Lys Arg  Ile Asp His Arg His  His Ala Leu Asp Ala  Leu Val Ile 
    1070                 1075                 1080             


Ala Cys  Ala Thr Lys Asp His  Val Asn Leu Leu Asn  Asn Gln Ser 
    1085                 1090                 1095             


Ala Lys  Ser Asp Thr Lys Arg  Tyr Asp Leu Lys Lys  Lys Ser Met 
    1100                 1105                 1110             


Lys Phe  Glu Lys Val Val Tyr  Asn Asp Ala Lys Thr  Gly Glu Lys 
    1115                 1120                 1125             


Ile Glu  Arg Glu Val Pro Lys  Gln Phe Leu Lys Pro  Trp Glu Asn 
    1130                 1135                 1140             


Phe Thr  Leu Asp Val Lys His  Asn Leu Glu Thr Ile  Ile Val Ser 
    1145                 1150                 1155             


Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys Ala Thr  Asn Tyr Tyr 
    1160                 1165                 1170             


Glu Lys  Tyr Val Glu Lys Asp  Gly Thr Lys Asn Lys  Glu Arg Val 
    1175                 1180                 1185             


Glu Gln  Thr Gly Thr Asn Trp  Ala Ile Arg Lys Pro  Met His Lys 
    1190                 1195                 1200             


Asp Thr  Val Ser Gly Lys Val  Asp Leu Pro Trp Val  Lys Val Pro 
    1205                 1210                 1215             


Lys Gly  Lys Ile Leu Thr Ala  Thr Arg Lys Ser Leu  Asp Ser Ser 
    1220                 1225                 1230             


Phe Asp  Leu Lys Ser Ile Gly  Ser Ile Thr Asp Thr  Gly Ile Gln 
    1235                 1240                 1245             


Lys Ile  Leu Lys Asn Tyr Leu  Ala Phe Lys Asp Gly  Asn Pro Glu 
    1250                 1255                 1260             


Leu Ala  Phe Ser Pro Glu Gly  Ile Asp Asp Leu Asn  Lys Asn Ile 
    1265                 1270                 1275             


Glu Lys  Tyr Asn Asp Gly Lys  Pro His Gln Pro Ile  Asn Lys Val 
    1280                 1285                 1290             


Arg Val  Phe Glu Leu Gly Ser  Lys Phe Gln Val Gly  Gln Ser Gly 
    1295                 1300                 1305             


Asn Lys  Lys Asp Lys Tyr Val  Glu Ala Ala Lys Gly  Thr Asn Leu 
    1310                 1315                 1320             


Phe Phe  Ala Val Tyr Glu Asp  Glu Lys Gly Lys Arg  Asn Tyr Glu 
    1325                 1330                 1335             


Thr Ile  Pro Leu Asn Glu Val  Ile Glu Arg Gln Lys  Gln Gly Leu 
    1340                 1345                 1350             


Ser Val  Val Asp Leu Lys Gly  Thr Asn Asp Phe Tyr  Leu Cys Pro 
    1355                 1360                 1365             


Asn Asp  Phe Val Tyr Ile Pro  Ser Gly Asp Glu Leu  Glu Asn Ile 
    1370                 1375                 1380             


Asn Asn  Val Asp Phe Lys Asp  Ile Lys Lys Glu Ile  Asn Glu Arg 
    1385                 1390                 1395             


Ile Tyr  Lys Val Val Ser Phe  Thr Gly Asn Arg Leu  Ser Cys Ile 
    1400                 1405                 1410             


Pro Tyr  Met Val Ala Thr Thr  Ile Val Asn Lys Leu  Glu Phe Thr 
    1415                 1420                 1425             


Gln Leu  Asn Lys Ile Glu Phe  Thr Lys Glu Lys Glu  Ile Cys Ile 
    1430                 1435                 1440             


Lys Leu  Asn Val Asp Arg Leu  Gly Asn Ile Ser Lys  Ala 
    1445                 1450                 1455     


<210> 55
<211> 18
<212> RNA
<213> Empedobacter sp.

<220>
<221> source
<223> /note="crRNA"

<400> 55
guugugaauu gcuuucaa                                                     18


<210> 56
<211> 75
<212> RNA
<213> Empedobacter sp.

<220>
<221> source
<223> /note="tracrRNA"

<400> 56
uugaaaagca auucacaaua aggauuauuc cguugugaaa acauucaagg cggggcaacu       60

cgucuuuuuu cuuuu                                                        75


<210> 57
<211> 127
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L1"

<400> 57
gagcggacag cagcuuccua uaucucguac guugugaauu gcuuucaaaa aguugaaaag       60

caauucacaa uaaggauuau uccguuguga aaacauucaa ggcggggcaa cucgucuuuu      120

uucuuuu                                                                127


<210> 58
<211> 127
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA L2"

<400> 58
ccaugauaua gacguugugg cuguuguagu guugugaauu gcuuucaaaa aguugaaaag       60

caauucacaa uaaggauuau uccguuguga aaacauucaa ggcggggcaa cucgucuuuu      120

uucuuuu                                                                127


<210> 59
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PAM"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<400> 59
nnrnnc                                                                   6


<210> 60
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 1"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 60
gagcggacag cagcttccta tatctcgtac nnnnnnnn                               38


<210> 61
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Target seq and PAM region of plasmid library 2"


<220>
<221> modified_base
<222> (31)..(38)
<223> a, c, t, g, unknown or other

<400> 61
ccatgatata gacgttgtgg ctgttgtagt nnnnnnnn                               38


<210> 62
<211> 122
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA with N's"


<220>
<221> modified_base
<222> (1)..(25)
<223> a, c, u, g, unknown or other

<400> 62
nnnnnnnnnn nnnnnnnnnn nnnnnguugu gaauugcuuu caaaaaguug aaaagcaauu       60

cacaauaagg auuauuccgu ugugaaaaca uucaaggcgg ggcaacucgu cuuuuuucuu      120

uu                                                                     122


<210> 63
<211> 4
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="4bp linker"

<400> 63
aaag                                                                     4


<210> 64
<211> 4
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="4bp linker"

<400> 64
gaaa                                                                     4


<210> 65
<211> 4
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="4bp linker"

<400> 65
acuu                                                                     4


<210> 66
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="6bp linker"

<400> 66
caaagg                                                                   6


<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NLS"

<400> 67
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 68
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="conserved sequence in base of hairpin stem of tracrRNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, u, g, unknown or other

<400> 68
unanng                                                                   6


<210> 69
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="APG05083.1/exemplary PAM"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 69
nnrncc                                                                   6


<210> 70
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="APG07433.1/exemplary PAM"


<220>
<221> modified_base
<222> (1)..(4)
<223> a, c, t, g, unknown or other

<400> 70
nnnnccr                                                                  7


<210> 71
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="APG07513.1/exemplary PAM"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 71
nnrncc                                                                   6


<210> 72
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="APG01688.1/exemplary PAM"


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(5)
<223> a, c, t, g, unknown or other

<400> 72
nnranc                                                                   6


<210> 73
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 73
gagcggacag cagcttccta tatctcgtac                                        30


<210> 74
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 74
gagcggacag cagcttccta tatctcgtag                                        30


<210> 75
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 75
gagcggacag cagcttccta tatctcgttc                                        30


<210> 76
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 76
gagcggacag cagcttccta tatctcgaac                                        30


<210> 77
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 77
gagcggacag cagcttccta tatctcctac                                        30


<210> 78
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 78
gagcggacag cagcttccta tatctggtac                                        30


<210> 79
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 79
gagcggacag cagcttccta tatcacgtac                                        30


<210> 80
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 80
gagcggacag cagcttccta tatgtcgtac                                        30


<210> 81
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 81
gagcggacag cagcttccta taactcgtac                                        30


<210> 82
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 82
gagcggacag cagcttccta tttctcgtac                                        30


<210> 83
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 83
gagcggacag cagcttccta aatctcgtac                                        30


<210> 84
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 84
gagcggacag cagcttcctt tatctcgtac                                        30


<210> 85
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 85
gagcggacag cagcttccaa tatctcgtac                                        30


<210> 86
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 86
gagcggacag cagcttcgta tatctcgtac                                        30


<210> 87
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 87
gagcggacag cagcttgcta tatctcgtac                                        30


<210> 88
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 88
gagcggacag cagctaccta tatctcgtac                                        30


<210> 89
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 89
gagcggacag cagcatccta tatctcgtac                                        30


<210> 90
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 90
gagcggacag caggttccta tatctcgtac                                        30


<210> 91
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 91
gagcggacag caccttccta tatctcgtac                                        30


<210> 92
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 92
gagcggacag ctgcttccta tatctcgtac                                        30


<210> 93
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 93
gagcggacag gagcttccta tatctcgtac                                        30


<210> 94
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 94
gagcggacac cagcttccta tatctcgtac                                        30


<210> 95
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 95
gagcggactg cagcttccta tatctcgtac                                        30


<210> 96
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 96
gagcggagag cagcttccta tatctcgtac                                        30


<210> 97
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 97
gagcggtcag cagcttccta tatctcgtac                                        30


<210> 98
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 98
gagcgcacag cagcttccta tatctcgtac                                        30


<210> 99
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 99
gagccgacag cagcttccta tatctcgtac                                        30


<210> 100
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 100
gaggggacag cagcttccta tatctcgtac                                        30


<210> 101
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 101
gaccggacag cagcttccta tatctcgtac                                        30


<210> 102
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 102
gtgcggacag cagcttccta tatctcgtac                                        30


<210> 103
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 4"

<400> 103
cagcggacag cagcttccta tatctcgtac                                        30


<210> 104
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 104
gagcggacag cagcttccta tatctcgtat                                        30


<210> 105
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 105
gagcggacag cagcttccta tatctcgtgc                                        30


<210> 106
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 106
gagcggacag cagcttccta tatctcgcac                                        30


<210> 107
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 107
gagcggacag cagcttccta tatctcatac                                        30


<210> 108
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 108
gagcggacag cagcttccta tatcttgtac                                        30


<210> 109
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 109
gagcggacag cagcttccta tatcccgtac                                        30


<210> 110
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 110
gagcggacag cagcttccta tatttcgtac                                        30


<210> 111
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 111
gagcggacag cagcttccta tacctcgtac                                        30


<210> 112
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 112
gagcggacag cagcttccta tgtctcgtac                                        30


<210> 113
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 113
gagcggacag cagcttccta catctcgtac                                        30


<210> 114
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 114
gagcggacag cagcttcctg tatctcgtac                                        30


<210> 115
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 115
gagcggacag cagcttccca tatctcgtac                                        30


<210> 116
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 116
gagcggacag cagcttctta tatctcgtac                                        30


<210> 117
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 117
gagcggacag cagctttcta tatctcgtac                                        30


<210> 118
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 118
gagcggacag cagctcccta tatctcgtac                                        30


<210> 119
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 119
gagcggacag cagcctccta tatctcgtac                                        30


<210> 120
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 120
gagcggacag cagtttccta tatctcgtac                                        30


<210> 121
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 121
gagcggacag caacttccta tatctcgtac                                        30


<210> 122
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 122
gagcggacag cggcttccta tatctcgtac                                        30


<210> 123
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 123
gagcggacag tagcttccta tatctcgtac                                        30


<210> 124
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 124
gagcggacaa cagcttccta tatctcgtac                                        30


<210> 125
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 125
gagcggacgg cagcttccta tatctcgtac                                        30


<210> 126
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="mismatch repair Table 6"

<400> 126
gagcggatag cagcttccta tatctcgtac                                        30


<210> 127
<211> 3210
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05083.1 mammalian codon optimized sequence"

<400> 127
atgagagagc tggattaccg gatcggcctg gatatcggga ccaactccat tggatggggc       60

atcatcgagc tgtcttggaa caaagacaga gaacagtacg agaaggcaag aatcgtggac      120

aagggcgtga gaatgttcga caaggccgaa atacccaaga ccggagccag cctggccgag      180

cctagaagaa ttgccagatc aagcagaaga cggctcaaca gaaagtctca gagaaaaaaa      240

gatattcgga acctgctggt ccagcacgag atcatcagcc aaaaggaact cgctagcctg      300

tatcctctga ccaagagcag catggacatt tgggacatca gactggacgg cctggacaga      360

ctgctggata gattcgagtg gaccagattg ctgatccacc tggctcagcg gagaggcttc      420

aaaagcaacc ggaagagcga gctgaaggac gtggaaaccg gcaaggtgct ctccagcatc      480

caggctaatg agaagcggct gtccctgtac agaactgtgg gcgagatgtg gatgaagaat      540

gaagatttta gcaagtacga caaaagaaga aatagtagca acgaatacgt gttctctgtg      600

tcccgggccg acctggaaaa ggaaatcgtg acactgtttg aagctcagcg gaagttccag      660

agcagctatg ccagcgccga tcttcaaaaa acctacctcc agatctgggc ccatcaactg      720

cctttcgcct ctggcaacgc catcgttaac aaggtgggct actgcagcct actgaaaggc      780

aaggagaaga gagttcctaa ggccacctac accttccaat acttcagcac cctggatcag      840

atcaacagaa ccagactggg cccaaacttc cagcccttca ccaaggaaca gagagatgtg      900

atcctggacg agatgtttaa ccggaccgat tattacaaga agaagaccat ccctgaggtg      960

acgtactacg atatcagaaa atggctggcc ctggacgaga caatccagtt caagggcctg     1020

acctacgacc ctaatgaaga actgaagaaa attgagctaa agtcttttat caatctgaag     1080

cctttctacg agataaagaa ggtggtgaca aactacgcca agaagacaaa tgaggccttt     1140

agcacactgg actatgacac ctttgcctac gccctgacag tgtacaagac cgacaaggac     1200

atccgctcct acctgaaaaa gagtaacaac ctgtccaaat gctgctacga cgaccaactg     1260

atcgaggaat tgctgacact gagctacacc aaattcggcc acctgagctt caaggctatc     1320

aaccacgttc tgcctatcat gcaggagggc agaacctacc aggaggccat tcaccagctc     1380

ggctacgatg ccacaaacct caaaaaagag aaccggtcta tgttcctgcc tctgttccct     1440

gacgagatca ccaaccccat cgtgaagagg gccctgaccc aggccaggaa ggtggtcaac     1500

gccatcatca gacgatacgg gtctccaaac agcgtgcaca tcgagctggc cagagagctg     1560

agcaagagcc acgacgagag aacaaagatc atgaaagctc atgatgaaaa ctacaaaaag     1620

aacaagggcg ctatcagcat cctgatcgag aacggtattc tgaatcctac aggttatgac     1680

atcgtccggt acaagctgtg gaaggaacag ggcgagagat gcgcctattc tctgaaacag     1740

atccccgcca acaccttctt caacgaaatg aagaaggagc ggtccggcag ccctgtgctg     1800

gaaatcgatc acatcctgcc ctacagccag agcttcatcg acagctacca caacaaagtg     1860

ctggtgtacg gggatgagaa ccagaaaaag ggcaatagaa tcccgtacac ctacttcctg     1920

gaaggcaaca aggactggga gtctttcgag agctatgtgc gcctgaactc ctttttcagc     1980

aagaaaaagc gaggatatct gctgaagaag gcttacctgc caagagagag taacatgatc     2040

aaggaacggc acctcaacga cacccggtac gccagctcct acctgaagaa cttcatcgag     2100

aagaatctga agttcaagga ggtggaaggc tctacccgga agaagcacgt gcaaaccgtg     2160

aacggcataa tcacagccca cctgagaaag agatggggcc tggaaaagga ccgccaggag     2220

acatatcttc atcacgctat ggacgccatc atcgtggcat gcaccgacca ccacatggtg     2280

acaaaggtga ccgagtacta ccagatcaaa gaaagcaata aatctattag aaagccttac     2340

ttccccctgc cttgggtggg ctttagagag gaaattctgt cccacctggc tcggcagcct     2400

atcgccagaa agatctctga agagctgaag atcggatacc agagcttcga ttacatcctc     2460

gtgtctagaa tgcctaaaag atcagtgacc ggcgccgccc acgagcagac cattatgaaa     2520

aagggaggca tcgacaaaaa aggaaaaacc atcatcatta agcgggtcta cctgaaggat     2580

atcaagttcg acgagaatgg cgatttcaag atggttggaa aggaacagga cctggctacc     2640

tacgaggcca tcaagcagag atacatcgag tacggcaagg aatccaagaa ggccttcgag     2700

acccctctgt ataagcccag caagaaaggc aaaggcaacc tgatcaagaa gatcaaagtg     2760

gaagtgcaaa ccaagagctt tgtgagagaa gtcaacggcg gagtggccca gaacggcgat     2820

ctggtgcggg ttgacctgtt cgagaaggat aatagatact acatgatccc catctacgtg     2880

atggataccg tgcacagcga acttcctaac aaggccgtga ccagcagcaa aggctatgag     2940

caatggctga ccatcgacaa cagcttcacc ttcaagttca gcctataccc ctacgacctg     3000

gtgcggctgg tcaagggtaa cgaggacaga ttcctgtact tttccaccct ggatattaac     3060

agtgatagac tcaacttcaa agacgtcaac aagcccagca agcaggccga gaacagatat     3120

agcctgaaga caatcgaaaa cctggaaaaa tacgaggtgg gcgtcctggg cgacctcaga     3180

tttgtgagac aggagatcag aaagaacttc                                      3210


<210> 128
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07433.1 mammalian codon optimized sequence"

<400> 128
atgagagagc tggactacag aattggcctg gacatcggca ccaacagcat cggatggggc       60

gtgatcgagc tgtcctggaa caaagaccgg gagagatacg agaaggtcag aatcgtggat      120

caaggcgtga gaatgttcga cagagccgag atgcccaaga caggcgccag cttagctgaa      180

cccagaagaa tcgccagatc cagcagacgg agactgaatc gcaagtccca gagaaagaaa      240

aacatccgga acctgctggt gcaacacggc gtgatcacac aggaggaact ggatagcctg      300

taccccctga gcaaaaagag catggacatc tggggcattc ggctcgacgg cctggacaga      360

ctcctcaatc atttcgagtg ggccagactg ctgatccacc tggctcagag acggggcttt      420

aagtccaaca gaaagagtga actgaaagat acagagacag gcaaggtgct gagcagcatc      480

caactgaacg agaaacggct gagcttgtat agaaccgtgg gcgagatgtg gatgaaggac      540

cccgacttct ctaaatacga taggaagaga aatagcccca acgaatacgt gttcagcgtg      600

tctagagccg agctggaaaa ggaaatcgtg accctgttcg ccgcccagcg gagattccag      660

agcccttacg ccagcaaaga tctgcaggag acatatctgc agatctggac ccaccaactg      720

cctttcgcca gcggcaatgc catcctgaac aaggtcggat actgctccct gttgaaaggc      780

aaagaaagaa ggattcccaa ggctacatac accttccaat acttctctgc tctggaccag      840

gtgaatcgga ccagactggg acctgatttc cagcccttca ccaaggagca acgggaaatt      900

atcttgaaca acatgttcca gaggacagat tactacaaga agaaaaccat ccccgaggtg      960

acctactatg acatacggaa gtggctggaa ttggacgaga caattcagtt caagggcctg     1020

aactacgacc ctaacgagga actgaagaag atcgagaaga agccttttat caatctgaag     1080

gccttctacg agatcaacaa ggtggtggcc aactacagcg aaagaaccaa cgagaccttc     1140

tccaccctgg actacgacgg catcggctac gccctgaccg tgtacaaaac cgacaaggat     1200

atccgcagct acctgaagag cagtcacaac ctacctaaga gatgctacga cgaccaactg     1260

atcgaggaac tgctgagcct gagctacaca aagttcggcc acctgtccct gaaagccatc     1320

aaccacgtgc tgtctatcat gcagaagggc aatacctaca aggaagccgt ggaccaactg     1380

ggctacgaca ccagcggcct taagaaggag aagaggtcca agttcctgcc acctatttct     1440

gatgaaatca cgaatccaat cgtgaaaagg gccctgaccc aggccagaaa agtggtgaac     1500

gccataatta gaagacacgg atctcctcac tccgtgcaca tcgagctggc cagagagctg     1560

agcaagaacc acgacgagcg gacaaagatc gtcagcgccc aggatgaaaa ctacaagaaa     1620

aacaagggcg ctatcagcat cctgtctgag cacggcatcc tgaaccctac aggctacgac     1680

atcgtgagat acaaactgtg gaaggagcag ggcgaacggt gcgcctacag cctgaaggaa     1740

atccctgccg atacattttt caacgagctg aagaaggaac gcaacggcgc ccctatcctt     1800

gaagtggacc acatcctgcc ctacagccag tccttcatcg actcctacca caacaaggtc     1860

ctggtgtaca gcgacgaaaa ccggaaaaag ggcaacagaa tcccttatac ctacttcctg     1920

gaaaccaaca aggattggga ggcctttgag cggtacgtgc ggagcaacaa attcttctcc     1980

aagaaaaagc gagagtacct tctgaagcgg gcttatctgc ctagagaatc tgagctgatc     2040

aaagaacgcc acctgaacga caccagatac gcctctacct tcctgaagaa cttcatcgag     2100

cagaacctgc agttcaagga agccgaggac aaccccagaa aaagacgggt gcaaaccgtg     2160

aacggcgtta tcaccgccca cttcagaaag cggtggggcc tggagaagga ccggcaggag     2220

acatacctcc atcacgctat ggacgccatc atcgtggctt gtacagacca ccacatggtc     2280

accagagtga ccgagtacta tcagatcaag gaaagcaaca agagcgtgaa gaagccctat     2340

tttcctatgc cttgggaagg cttccgggac gagctgctga gccacttggc ttctcagcct     2400

atcgccaaga aaatcagcga ggaactgaag gccggctacc agagcctgga ctacatcttc     2460

gtgtccagaa tgcctaagag aagcattaca ggcgctgctc ataagcagac catcatgcgg     2520

aagggaggaa ttgacaagaa gggcaaaaca atcatcatcg aacggctgca cctgaaggat     2580

atcaagttcg acgagaacgg agatttcaag atggtgggca aggaacagga catggccaca     2640

tacgaagcta ttaaacagag atacctggag cacggcaaga atagcaagaa ggccttcgag     2700

acccctctgt acaagcccag caaaaagggc acaggtaacc tgatcaagcg ggtgaaggtg     2760

gaaggacagg ccaagagctt tgtgagggaa gtgaacggcg gagtggccca aaatggcgat     2820

ctggttagag ttgatttgtt tgagaaggat gataagtact acatggtccc catctacgtg     2880

ccagacaccg tgtgtagcga gctgcccaaa aaggtggtcg ccagctctaa gggctatgag     2940

cagtggctga cactggataa cagcttcacc tttaagttca gcctgtaccc ttatgatctg     3000

gtgcggctgg tcaagggaga tgaggatcgg ttcctgtact ttggcaccct ggacatcgac     3060

agcgacagac ttaacttcaa ggacgtgaac aagccaagca agaagaacga gtaccggtac     3120

agcttgaaaa ccatcgagga cttggagaag tacgaggtgg gcgtgctggg cgatctaaga     3180

ctggtccgga aggaaactcg aagaaacttc cac                                  3213


<210> 129
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07513.1 mammalian codon optimized sequence"

<400> 129
atgcgggaac tggattacag aattggactg gacatcggga ccaactcaat tggctgggga       60

gtgatcgagc tgagctggaa caaggacaga gagcagtacg agaagaccag aatcgtggac      120

aagggcgtta ggatgttcga caaggccgag atccccaaga ccggagccag cctggccgag      180

cctagacgta tcgccagatc ctccagacgt agactgaaca gaaagtccca gaggaagaag      240

gacattcgga acctgctggt gcaacacgag atcattagcc aaaaagaact gaccagcctg      300

taccctctgt ctaaatccag catggacatc tgggacatcc ggctggacgg cctggacaga      360

ctgcttgata gattcgagtg ggcccggctc ctgatccacc tggctcagcg gcggggcttt      420

aaaagcaacc ggaagtctga gcttaaagac gtggaaacag gaaaagttct gtccagcatc      480

caggtgaatg aaaagcggct gagcctgtac agaaccgtgg gcgagatgtg gatgaagaac      540

gccgattgca gcaagtacgg caaacgtaga aatagcccca acgagtacgt gttcagcgtg      600

tctagagccg acttggagaa agaaattgtg acacttttcg aggcccagcg aaaattccac      660

agcagctacg ccagtgtgga cctgcagaag acatacatcc aaatctgggc tcatcaactg      720

ccatttgcct ctggcaatgc cattgtgaac aaggtgggat actgctctct gctgaagggc      780

aaagaaaaga gagtgcctaa ggccacatac acctttcagt attttaacac cctggaccag      840

atcaaccgga caagactggg ccctaacttc caacctttca ccaaggagca gagagatatc      900

atcctagaca aaatgttcca gagaaccgac tactacaaga aaaaaacaat ccctgaggtg      960

acatactacg atatcagaaa gtggctggcc ctggacgaaa ccatccagtt caagggcctg     1020

acctacgatc ctaatgaaga actgaagaag atcgagatga agccattcat caacctgaaa     1080

cctttctacg agatcaagaa ggtggtgacc aactacgcca agaagacaaa cgaggtgttc     1140

tctgccctgg actatgacac cgtggcttat gccctcaccg tgtacaaaac agacaaggat     1200

atcagaagct accttaagcg gtccaacaac ctgagcaaga gatgttacga cgaccaactg     1260

atcgaggaac tgctgacact gagctacacc aagttcggcc acctgtcctt caaggccatc     1320

aatcacgtgc tgcccatcat gcaggagggc agaacctacc aagaggctat tcaccaactg     1380

ggctatgaca cgaccaacct gaagaaggaa aatagaagca tgttcctgcc catcatccct     1440

gacgagatca ccaaccctat cgtgaagcgg gccctgacgc aggcccggaa agtggtgaat     1500

gccatcatcc gcagatacgg ctctcctaat tctgtccaca tcgagctggc cagagagctg     1560

agcaaaagcc acgacgagcg gaagaagatc atgaccgccc acgacgagaa ctacaagaaa     1620

aacaagggcg ccgtgtccat cctgatcgat aacggcatcc tgaatcctac aggatacgat     1680

atcgtgcggt acaagctgtg gaaggaacag ggcgaaagat gcgcctatag cctgaaaaaa     1740

atccccgcca acaccttctt caacgagcta aaaaaggaac ggagcggccc acctgtgctg     1800

gaagtggacc acatcctgcc ctacagccag agcttcatcg acagctacca caacaaggtg     1860

ctggtgtacg gcgacgagaa ccagaagaag ggcaatagaa tcccttacac atttttcagc     1920

gaagaagata aggaatggga gagcttcgag agctacgttc ggagcaacag cttcttcagc     1980

aagaaaaagc gcggctacct gctgaagaag gcctacctgc ccagagaaag caacctgatc     2040

aaggaacggc acctcaacga cacacggtac gccagcagtt acctgaagaa tttcatcgag     2100

aagaacctga agttcaagga agccgtgggg atcacccgga agaagtacgt gcaaaccgtg     2160

aacggcgtga tcaccgccca cctgcggaag cggtggggcc ttgagaagga ccggcaggag     2220

acctacctgc accacgctat ggacgccatc atcgtggcct gcaccgatca ccacatggtg     2280

acgaaggtga ccgagtacta ccagatcaaa gaaggcaata agagcatcaa gaagccttat     2340

tttcctctgc cctggatggg cttcagagaa gaaatcctgt ctcacctgga gtctcaacct     2400

atcgccagaa aaatttctga agagctgaaa attggatacc agtcccccga ttacatcctg     2460

gtcagccgga tgcctaagag aagcgtgacc ggcagcgccc acgatcagac cgtgatgaag     2520

aagggcgata tcgataagaa gggcaagaca atcatcatca agcgggtgca cctgaaggat     2580

atcaagttcg acgaaaatgg cgacttcaaa atggtgggca aggagcagga cctggctaca     2640

tacgaagcta tcaaacagag atacctggag taccggaagg aaagcaagaa ggccttcgag     2700

acccctctgt acaagccatc taaaaaagga aaaggtaacc tgatcaaaaa gatcaaggtg     2760

gaagtgcaaa ccaaatcttt cgtgagagag attaacggcg gagtggccca gaacggcgac     2820

ctggttagag tggatctgtt cgagaaggac aacagatatt acatggtccc catctacgtg     2880

gtggacaccg tgcggtctga actccccaac aaagcagtga caagctccaa aggctatgaa     2940

cagtggctga gcatcgacaa tagtttcacc ttcaagttta gtctgtaccc ctacgacctc     3000

gtgcggctgg tcaagggcga cgaggatcgc ttcctgtact tctccaccct ggatatcaac     3060

agcgacagac tgaacttcaa ggacgtgaac aagcctagca agcaggctga ataccggtac     3120

agcctgaaga cgatcgagaa cctggaaaaa tacgagatcg gtgttctggg agatctgaga     3180

ctcgttagac aggagacaag aaaaattttc aag                                  3213


<210> 130
<211> 3216
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG08290.1 mammalian codon optimized sequence"

<400> 130
atgagcgagc tggattatag aatcggcctg gatatcggca ccaattctat cggatgggga       60

gtgatcgagc tgttctggaa caaggatcgg gaacggtacg agaaggtccg catcgtggac      120

aaaggggtca gaatgtttga caaggccgag atccccaaca agggcgccag cctggccgag      180

cctcggagaa tcgcccggag cagcagaaga cgcctgaaca ggaagtccca aaggaagaag      240

gagatccgga acctgctggt gcaacacggc atgatcaccc aagaggaact ggacctcctg      300

taccctctga gcaaaaagtc catcgatatc tgggacatca gactagacgg cctggacaga      360

ctgctgaacc acttagagtg ggctagactg ctgattcacc tggcccagcg gcggggcttc      420

aagagcaacc gcaaaagcga gctgaaggac gctgaaacag gcaaggtgtt gtctagcatc      480

caggtgaacg agaagcggct gttcctgtac agaaccgtgg gggaaatgtg gatcaaggac      540

gcagagttca gcaagtacga caggcgtaga aactccccaa acgaatacgt gttcagcgtg      600

tcaagagccg acctggaaaa ggaaatcgtg acactgtttg aggctcagag aaagttccag      660

agcagctatg cctctaaaaa tctgcaggag acctacctgc agatctgggc ccaccaactg      720

cctttcgcca gcggcaatgc catcctgaac aaagtgggct actgcagcct gctgaaaggg      780

aaggaaaggc ggattcccaa ggccacatac accttccagt acttctccgc cctggatcag      840

gttaaccgga cccggctcgg ccctgacttc caacctttca cccaggaaca aaaggagatc      900

atcctggata agatgttcca gagaacagac tactacaaga agaagaccat ccccgaggtt      960

tcttattatg atatcagaaa gtggctggaa ctcgacgaga caatccagtt taagggactg     1020

aattacgacc ccaacgaaga gctgaagaag atcgaaaaaa aacctttcat caacctgaag     1080

gccttctacg agatcaagaa ggtggttgct aactacgccg aaagaacaaa tgaagccttt     1140

tctaccctgg actacgacgc tatcgcctat gccctgacag tctacaagac cgacaaggac     1200

atccggtcct acctgaagaa atccaacaac ctgtccaagc ggtgctacga tgatcaactg     1260

atcgaggaac tgtttaccct gagctacacc aaattcggcc acctgtcttt caaggccatt     1320

aaccacgtgc tgcctatcat gcaggagggc agaacctacc aggaggccat acaccaactg     1380

ggctacgaca ccaccaacct gaagaaagag aatagaagca tgttcctgcc tctgatccct     1440

gacgagatca caaaccccat tgtgaagcgg gccatcaccc aggccagaaa ggtggtgaac     1500

gccatcatca gaagatacgg ctctcctaac agtgtgcaca tcgaactggc cagagagctg     1560

agcaagagcc acgatgagcg gaaaaagatc atgaccgccc acgacgagaa ctacaagaaa     1620

aataagggcg ctatttctat cctgatcgag aacggcattc tgaaccctac cggctacgac     1680

atcgtgagat acaagctgtg gaaggaacaa ggcgagagat gcgcctacag cctgaaagaa     1740

attccacctg atactttttt caacgagctg aagaaagaaa gaaacggcag ccccattctg     1800

gaagtggacc acatcctgcc ttacagccag tccttcatcg acagctacca caacaaagtg     1860

ctggtgtact ctgacgagaa cagaaacaag ggcaacagaa tcccttacac ctacttcctg     1920

gaaacaaaca aggactggga ggcctttgaa agatacgtgc ggagtaacaa actgttttct     1980

aagaaaaaga gagaatatct gctgaagaag acttacctgc ctagagagtc tgaactaatc     2040

aaggaacggc acctgaacga cactcggtat gcttctacat tcctgaagaa tttcatcgag     2100

cagaatctgc agttcaaaga ggtcgaggtc aatctgagaa aaaagagagt gcaaaccgtg     2160

aatggcgtga tcaccgccca cctcagaaag cgttggggcc tggagaagaa ccggcaggag     2220

acgtacctgc accacgctat ggacgccatc atcgtggctt gtacagacca ccacatggtg     2280

acccggataa cagagtacta ccagatcaag gaatccaaca agagcgtgaa gaaaccttac     2340

ttccccatgc cttgggaggg ctttagagat gagctgttgt ctcacctcgc tagccagcct     2400

atcgcaaaga agatcagcga ggaactgaag gccggctacc agagcagcga ctacatcttc     2460

gtgtccagaa tgcccaagag aagcgtgacc ggcgccgccc atgatcagac catcagaaga     2520

aagggcggca tcgacaagaa gggcaagaca atcatcatta agcgggtgcg gctgaaagat     2580

atcaagttcg acgaaaacgg cgatttcaag atggtgggca aagagcagga cctggcaacc     2640

tacgaggcca tcaagcagag atacctggag cacagaaaga acagtaagaa ggccttcgag     2700

acccctctgt acaaacctag caagaaggga acaggaaacc tgattaagcg ggtgaaaatc     2760

gagggacaga ctaaggcctt cgtgcgggaa gtgaacggag gcgtggccca aaatagcgac     2820

ctggtcagag tggacctgtt cgagaaggac gacaagtact atatggtgcc tatctacgtg     2880

ccagacaccg tgtgtagcga gctgcctaag aaggtggtta agagcggaaa aggctatgag     2940

cagtggctga ccctggacaa cagcttcacc ttcaagtcta gcctgtaccc ctacgatctg     3000

gtgcggctcg tgaagggcaa cgaggacaga ttcctgtact tcggcacact ggacattgac     3060

tccgatagac tgaatttcaa ggatgtgaac aagcccagca agcagaacga gtaccggtac     3120

agcctgaaaa caatcgagaa cctggaaaaa tacgaggttg gagtgctggg agatctgcgg     3180

ctggtgaaac aggagaccag gaggatcttt aacaga                               3216


<210> 131
<211> 4011
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05459.1 mammalian codon optimized sequence"

<400> 131
atgaaaaaag attacgtgat cggcctggac attggcacca acagcgtcgg ctgggccgtg       60

atgacagagg actaccaact ggtgaagaag aagatgccaa tctatggcaa tactgagaag      120

aaaaagataa aaaagaattt ctggggcgtg cggctgtttg aggagggcca caccgccgag      180

gatcggcggc tgaaacggac cgctagaaga cggatctctc gccgcagaaa tagactgaga      240

tatctgcagg ccttcttcga ggaagccatg accgccctgg acgagaactt cttcgccaga      300

ctgcaggaga gcttcctggt gcctgaggac aagaaatggc accggcaccc tatcttcgcc      360

aagctggagg atgaggtggc ctatcacgaa acctacccta caatctacca cctgagaaag      420

aaactggctg attcctctga acaggctgac ctgagactga tctatctggc cctggcccat      480

atcgtgaagt acagaggcca cttcctgatc gaaggaaagc tgagtaccga gaacatcagc      540

gtcaaggagc agttccagca gttcatgatt atctataacc agacatttgt gaacggcgaa      600

agccggctgg tgtctgcccc tctgcctgag agcgtgctga tcgaagaaga gctgaccgaa      660

aaggccagcc ggacaaagaa atctgagaag gtgctgcaac agtttcctca ggagaaagcc      720

aatggactgt tcggccagtt cctgaaactt atggtaggca acaaagccga tttcaagaaa      780

gtctttggcc tggaagaaga ggccaaaata acatacgcca gcgagtccta cgaggaggat      840

ctggaaggca ttctggccaa ggtgggcgac gagtacagcg atgttttcct ggccgctaag      900

aacgtctacg acgccgtgga actgtctacc atcctggccg actccgacaa gaagagccac      960

gccaagttgt ctagtagcat gatcgttaga ttcaccgagc accaggagga cctgaagaag     1020

ttcaagcggt ttatcagaga gaattgcccc gacgagtacg ataacctgtt caagaacgag     1080

caaaaagacg gctacgccgg ctacatcgcc cacgccggca aggtgtccca actgaagttc     1140

taccagtacg tgaagaagat aatccaggac atcgccggcg ccgaatactt cctggagaaa     1200

atcgcccagg agaacttcct gcgaaaacag aggaccttcg acaacggcgt gatcccccac     1260

cagatccacc tggccgagct gcaggccatc atccacagac aggctgctta ctaccctttc     1320

ctgaaggaaa atcaggaaaa gattgagcaa ctggtgacat tcagaatccc ctactacgtc     1380

ggccctctga gcaaaggaga tgccagcacc ttcgcctggc tgaaaagaca aagcgaggaa     1440

cctatccggc cttggaacct gcaagagaca gtggacctgg accagtctgc taccgcattc     1500

atcgagagaa tgaccaactt cgatacctac ctgccttctg agaaggtgct gcccaagcac     1560

agcctgctct acgaaaaatt tatggtgttc aacgagctga ccaagatttc ttacactgat     1620

gacagaggca tcaaggccaa cttcagcggc aaggagaagg agaagatatt cgactacctg     1680

tttaagaccc gccggaaggt gaagaaaaag gatatcatcc agttctaccg gaacgagtac     1740

aacaccgaga tcgtcaccct gtctggcctg gaagaggacc agttcaatgc cagcttcagc     1800

acctaccaag atctgctgaa gtgcggccta actagagccg aactggacca ccctgataat     1860

gccgagaaac tggaggacat cattaagatc ctaaccatct tcgaggatag acagcggatc     1920

agaacacagc tcagcacctt caagggacag ttcagcgccg aggtgctgaa gaagctggaa     1980

cggaagcact acaccggctg gggcagactg tccaagaaac tcatcaacgg catctacgac     2040

aaggaatccg gaaagacaat cctggactac ctgatcaaag atgacggcgt ttctaagcac     2100

tacaacagaa acttcatgca gctaatcaac gacagccaac tgagcttcaa gaacgccatc     2160

cagaaggccc agagcagcga gcatgaggaa accctgtctg agaccgtgaa cgagctggcc     2220

ggcagccctg ccatcaagaa aggcatctac cagagcttaa aaatcgttga tgagctggtt     2280

gccatcatgg gctacgcccc taagagaatc gtggtggaga tggctagaga gaaccagaca     2340

acaagcaccg gaaagagaag aagcatccag aggctgaaga tcgtggaaaa agctatggcc     2400

gagattggaa gcaacctgct caaggaacag cctaccacaa acgagcaact gagagataca     2460

agactcttcc tgtattatat gcagaacggt aaggacatgt acaccggcga cgagctgagc     2520

ctgcacagac tgtctcacta cgacatcgac cacatcattc ctcagtcctt catgaaggac     2580

gattccctgg ataacctggt gctggtgggc agcaccgaga accggggcaa gtctgacgac     2640

gtgcccagca aggaagtggt gaaggacatg aaagcctact gggagaagct ctacgctgct     2700

ggcttgatca gccagcggaa attccagaga ctgacgaagg gcgagcaggg cggcctgacc     2760

ctggaggaca aagctcattt catccagaga caactggtgg agacaagaca gatcaccaag     2820

aacgtggctg gaattctgga tcagagatac aacgccaaca gcaaagaaaa aaaggtgcaa     2880

atcataacac tgaaagcctc tctgaccagc cagttccgga gcatcttcgg cctgtataag     2940

gtcagagaag tgaacgacta tcaccacggc caggatgcgt acctgaactg cgtggtggcc     3000

actacactcc tgaaagtgta ccccaacctg gctcctgagt tcgtgtacgg cgagtacccc     3060

aagtttcagg cctttaagga aaacaaggct acagccaaga ccatcatcta caccaatctg     3120

atgcggtttt tcaccgagga tgaacccaga ttcatgaagg acggcgagat cctgtggagc     3180

aacagctacc tgaagaacat taagaaagaa ctcaactacc atcagatgaa catagtgaaa     3240

aaggtggaag tgcaaaaggg tggcttctcc aaggaaagca tcaagcctaa gggccccagc     3300

aacaagctga tccctgtgaa gaacgggttg gacccccaga aatacggcgg atttgactct     3360

ccagtggtcg cttacacagt gctgtttacc cacgagaagg gcaaaaaacc actgatcaag     3420

caggagatcc tgggaatcac catcatggaa aagaccagat tcgagcagaa tcctatcctg     3480

ttcctggaag aaaaaggctt cctgaggcct agagtgctga tgaagctgcc taaatacacc     3540

ctgtacgagt tccctgaggg aagacggcgg ctgctggcca gcgccaaaga agcccagaaa     3600

gggaatcaga tggtgctccc cgaacacctg ctgaccctgc tgtaccacgc caaacagtgt     3660

ctgctgccta accagagcga atctctcgct tacgtggaac aacaccaacc ggagttccaa     3720

gagatcctgg agagagtggt ggacttcgct gaggtgcaca cactggccaa gagcaaggtg     3780

caacagatcg tgaaactgtt tgaggcaaac cagaccgcag atgtgaagga aatcgccgcc     3840

tccttcatcc aactgatgca gttcaacgca atgggagccc catctacctt taaattcttc     3900

cagaaggaca tcgagcgggc ccggtacact agcatcaagg aaatcttcga cgccaccatc     3960

atctaccaga gcacaaccgg cctctacgag acacggagaa aggtggtgga c              4011


<210> 132
<211> 4308
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG04583.1 mammalian codon optimized sequence"

<400> 132
atggccaaga atatcctggg cctggatctg ggtacaaaca gcatcggctg ggctctggtc       60

cagcaggact tcgagaacaa ggagggaaac atcctgggca tgggatctag aatcatccct      120

atgagccagg acatcctggg cgaattcggt aagggcaaca gcatcagcca gaccgccgag      180

agaacaggat accggggcgt gcgtagactg agagagagac acctcctgag aagagagaga      240

ctgcatagag tgctgcacct gctcggcttt ctgcctaagc actacgatga aaaaatcgac      300

tttacacaaa gattcggcaa gttcatcaac caggctgagc ctaagctggc ttttgatagc      360

gagttcctgt tcaaggacag cttccacgag atgctggccg acttcaagca gaatcaacct      420

gaattcctga aagacaagaa cggagaggac tgcctggttc cttacgactg gaccatctac      480

tacctgagaa agaaggctct gacccagaag atcgagaaat acgaactagc ttggctgatc      540

ctgaacttca accaaaagcg gggctactac cagcttagag gcgaagaaga gaaggaaaac      600

cctaacaaac tggtgggctt ccactctctg aagattgttg atgtgatccc tgatgccgag      660

accaacaaaa agggcgagac atggtacagc ctgcacctgg aaaacggctg ggtgtacagg      720

cggagcagca agatcagcct ggccgactgg aaggacaagg ttcgggactt catcgtcact      780

acagatctga acgacgatgg cagcgagaag ctggacaagg acggcatcgt gaagaggtcc      840

ttcagagccc cttctgccga cgattggaca ctcctgaaaa aaaagactga gaaggacatc      900

gacaactcca acaagactgt gggcacctac atctacgaca acttgctgct gaaccctaaa      960

cagaagatca aggggaaaat ggtcagaacc atcgaacgaa agttctacaa gcaggagctg     1020

gagcaaatcc tgaaaaccca gaaagaattt cactccgagc tgcagtctga aaacctgctg     1080

caggactgcg tgagggagct gtaccggaac aacgagcagc accagcagat gctggaagcc     1140

aaggattttg tgcacctgtt cctgaacgat atcatcttct accagagacc cctgcgcagc     1200

cagaaaagct ctattagcaa ctgcaccctg gaattccgga agagcaagaa cgagaatgga     1260

gaagaagtga tccaccggct gaaggtgatc gccaagtcca acccctacta tcaagagttt     1320

cggctgctgc agtgggtgca aaacctggct atctacacta aggacgacga caaaaacgtc     1380

acaaacgaat tcctgaagag cacccaggac tgggaggatc tgctgagatg gctgcacagc     1440

aagaaagaaa tcaagcagga tgccctgatc aaattcctga tcgaaaagaa aggcctgaag     1500

ggtaaggccc tgaccattga agtggctaag tacagatgga attacgtgca agacaaggat     1560

tatcctggca acgagacaag atacctgatt cagagccggc tggacaaggt ggaatacgcc     1620

cctaaggact tcctcacgta cgaaaatgag atggccctgt ggcacatcat ctactctatc     1680

aacgataaga tcgaatacga aaaggcccta aagagcttcg ccaacaagaa aggtctcgac     1740

gaggtgacct tcgtggaagc ctttaagaaa ttcccacctt tcaagagcga ttacggcagc     1800

ttcagcgaga aggccatcaa gaagctgctg cctctcatgc ggttcggcac acaatggaac     1860

tgggacaaca tcgaccagaa ctcgaaggaa aggattggaa aaatcctgac cggcgagtac     1920

gacgagaata tcaagggtag agtgcgggaa aaagctagac acctgaacag cgagacggac     1980

tttcaggcgc tccctctgtg gctggcccag tacgtggtgt acggcagaca tagcgaagct     2040

gacatcgccg gcaagtggaa tagtgtggac gacctgaagc agttcttgga cgacttcaag     2100

caacacagcc tgagaaatcc cattgtagaa caggtgatta ctgagacact gcgggccgtg     2160

aaggatatct ggaacttcta cggcaagggc gccaaggact ttttctctga gatccacatc     2220

gagctgggaa gagagatgaa aaacaccgcc gacgagagaa aaaggattac cacaatggtg     2280

acagataatg agaataccaa tctgagaatc aaagctctgc tggctgagat ggccctggat     2340

cagaacgtgg acaatgtgcg gccttacagc cccatgcagc aagaaatcct gaaaatctat     2400

gaggaaggcg tgctgaacgc cgaagagaac atcgacgatg acatcctgaa gatctctaaa     2460

actgctcagc ctagcgctac cgatctgaag agatacaagc tgtggctgga acagaagtac     2520

agaagcccct ataccggaca gatgatccct ctgaacaagc tgttcacccc tgagtatgaa     2580

atcgagcaca ttatccccca gagcagatac ttcgacgatt ctatgagcaa caaggtgatc     2640

tgcgaggccg ccgtgaacaa gctgaaggat aaccagatcg gcctggtgtt catcaagaac     2700

caccacggcg aagtggtgga ctttggcatg ggcaagcagg tgaaaatcct ggaggtgtct     2760

gattacgaag atttcgtgaa gcagaactac aacaaaaaca gaggcaaacg gaacaagctg     2820

ctcctcgaag atatccccga gaaaatgatt gaacggcaac tgaacgatac cagatatatc     2880

agcaagtaca tcactcaggt gctgtctaat atcgtcagag acgacaagga aggctctaag     2940

gatgacggag tgaacagcaa gaacattgtg cccggcaacg gcaagattac aaccagactc     3000

aagcaggatt ggggcctgaa cgatgtgtgg aacgacctgg tgctgcctag attcgagaga     3060

atgaacaccc tcacaaactc caatgatttt acaagcaaga acacacacgg caagaccatt     3120

cctaccgtgc ctatcgagct gagcaagggg ttcagcaaaa agcggatcga tcacagacac     3180

cacgctatgg acgccctggt gatcgcctgc gccacccggg accacgtgaa cctgctgaat     3240

aacgaatcca gcaagtctga cacaaagcgg tacgacctga atagaaaact gagaaaatac     3300

gagaaggtgg cctacaacga ccccaaaacc ggcgagagga ttgaaaaaga agtgccaaaa     3360

gacttcatca agccttggga aacttttacc gaagatacca gaacactgct ggagaatatc     3420

gtgatctcat tcaaacagaa cctgagagtg atcaacaagg ccaccaacta ctacgagaag     3480

atcgagaacg gcaaaaaggt gaaggtggaa caaaagggaa tcaactgggc cgtgagaaag     3540

gctctccata aggagaccgt gtccggccag gtccaccttg acagaatcaa ggtggccaag     3600

ggcaagatcc tgaccgccac aagaaagacc ctggacgctt cttttaacga gaaaaccata     3660

gagagcatca ccgataccgg catccagaag atcctgctga actacctgaa gtcaaaggac     3720

aacaaccctg aggtggcctt ctccccagaa ggaattgagg aactaaacaa gaatatcaga     3780

ctgtacaatg acggcaaggc ccaccagcca atcctaaaag tgcgggtgtt cgagcagggc     3840

agcaagttca cactgggcga gacaggcaac aagacaacca agttcgtgga agctgccaag     3900

ggcaccaatc ttttcttcgg aatctacgag gacaagagcg gaaaacgtag ctacgagacc     3960

atccccctga atatcgttat tgaaagacag aaacagggcc tccaggccgt gcccgagacc     4020

aacgagaagg gcaagcaact gctgttcacc ctgagcccca acgacctggt ctacgtgcca     4080

gaggaaggcg tattcgacga gaacaacatc aaggtggata gaatctacaa ggtcgtgtct     4140

ttcagcacat accaatgttt tttcgtgcgg aacgacgtat ctaccagcgt ggtcaacaag     4200

gtggagtaca gcgccctgaa caagatggaa aaatccatcg acaatatcat gatcaaggaa     4260

aactgtgtga agctgaatgt ggaccggctg ggtaagatca gcaaggcc                  4308


<210> 133
<211> 4368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG01688.1 mammalian codon optimized sequence"

<400> 133
atgatgatca agaacattct gggactggat ttgggcacaa acagcattgg atgggctctg       60

atcaagcagg acttcgagaa caaacacggc gagatcctgg gcatgggcag cagaatcatc      120

cctatgagcc aggatatcct gggcgatttc ggcaaaggga actcgataag ccagactgct      180

gacagaacca agtacagaag cgtgcggaga ctgagagaaa gattcttgct gcggcgggaa      240

cgcctgcacc gggtgctcca cctgctgaac ttcctccctc aacactacgc ctctcagatc      300

gacttcgaga agaagttcgg caagtttaag tctgagaccg aacctaagct ggcctgggaa      360

aactggggag gtaaattctc tttcctcttc cagaacagct tcaacgagat gctggaagac      420

ttcaaggccg ccggccaggg actcaagatt ccctatgact ggaccatcta ctacctacgg      480

aagaaagctc tgtcccagaa gatcgagaaa gaggagcttg cctggattct gctgaacttc      540

aaccagaagc gaggctacta ccagctcaga ggcgaggaag aagaagagaa cccgaacaag      600

ctggtggagt tctactccct gaagatcgtg gatgtggtcg ccgacgagcc tcagaagggg      660

aagagcgaca tctggtattc tctgatcctg gaaaacggct gggtctaccg cagagccagt      720

aagatcccac tgtttgattg gaaggataag accagagatt tcatcgtcac cacagacctt      780

aatgacgaca gaagcgtgaa gaccgacaaa gagggcaacg agaagcggtc ctttcgggcc      840

cctagcgaaa atgattggac cctggtcaag aagaagacag agcaggagat tgaccagagc      900

cacaagaccg tgggcaccta catctacgag acactgctgc tcaatccaaa gcagaaaatc      960

aagggcaagc tggtgcgaac aatcgagaga aaattttata aggacgagct gaagcaaatc     1020

ctggaaaagc agaaggaatt tcaccaggag ctgaaaaacg acgatctgta caacgactgc     1080

atcagagagc tgtaccggaa caacgaggcc caccaactga ccctgagcaa gaaagatttc     1140

gtgcacctgc tgatggacga tctgatcttc taccaaagac ccctgcgaag ccagaagtcc     1200

agcatctcta actgcaccct ggaattcaga aaatacaagg acgaaaacgg catcgaacac     1260

acccagtacc tgaaggccat cccaaagagt aatccgtact accaagagtt tagactgtgg     1320

cagtggatgt acaacctgaa catctacaga aaggacgacg aggctaatgt gaccaaggaa     1380

ttcctgaaca ccaataagga cttcgagagc ctgtttgagt tcctgaataa tagaaaggaa     1440

atcgaacaga agcctctgat caagttcctc ctggaacaga aagatattaa caagaagctg     1500

ctgaacgccg aggccgaaaa gtatcggtgg aattacgtgg aagataagaa gtatccttgc     1560

aacgaaacga agaccatgat ctccagcaga ctggacaaag tggagaatat ctctgacgac     1620

ttcctgacca gagacattga gcagaagatc tggcacatca tctacagcgt caacgacaag     1680

atagaatacg agaaggccct gaagtccttc gccaccagaa acgatctcga cgagaacagc     1740

tttatcgaag cctttaagaa gttcagccca ttcaagagcg agtacggatc tttttctgag     1800

aaagccatca agaaactgct gcccctgatg agactgggaa agtactggta cgaggacgag     1860

attgtgaagc actctgatat ttactttaag aacatcgaaa atcttctggg cgacttctcc     1920

aacagagata aaaaaatatc tgaggaagac aaagagaaat ggaacaagtc tatcaacctg     1980

aaactgcagg aggaactgaa ggactttcag accgccgaga tcgacctgtt ccagggcctt     2040

agactccata tcgcccagta cctggtgtac ggccggcaca gcgaagccag catgatcgga     2100

aagtggaaca gcgccgagga tctggaagaa ttcctgaagg acttcaagca gcacagcctg     2160

agaaacccca tcgtcgagca agtgatcacc gagaccctga gggtggttaa ggatatatgg     2220

ctgaaatacg gcaacggcgc caaggacttc ttcaacgaga ttcacatcga gctgggcaga     2280

gaaatgaagc tgcctgccga cgaccggaaa aagctgacca accagatcag cgagaacgaa     2340

aacacaaatt tcagaatcaa ggccctgctg gctgaaatga tgaacgacag cagtgtggaa     2400

aatgtgcggc ctttcagccc tatgcagcag gagatcctga agatctatga agatgacgtc     2460

ctgaagtctg acattgaaat cgaggatgac atccttaaga tctctaaaac cgcccagcct     2520

tctcctagcg atctcaagcg atacaagctc tggctggagc agaagtacaa gtctccatac     2580

accggccaga tcatacctct gaacaagctg tttacccctg aatacgagat cgagcacatt     2640

atccctcagt ctagatattt cgacgacagc ttcagcaaca aagtgatctg cgagagcgcc     2700

gtgaacaagc tgaaagacaa ctacattggc ctggaattca tcaagcaatt tggaggcacc     2760

atcatcgaac tgggctttgg caagtccatc aaagtgttcg agaccaaaga gtacgaggac     2820

ttcgtgaaga aacactacgc caacaatcag ggcaagagaa acaagctgct catggaagac     2880

atccccgaga aaatgatcga gagacagatg aacgacacca gatacatctc taagtacatc     2940

agcggagtgc tgagcaacat cgtcagagtg gaagatggat ctgatgaggg cgtgaacagc     3000

aagaacatcg tgcccggcaa cggcaagatt acaacacaac tgaagcagga ctggggcctg     3060

aatgacgtgt ggaacgacct tatcctgccg cggttcgaga gaatgaatca actgaccaac     3120

agcaaggtgt tcacagcctg gaacgaaaac taccagaagt tcctgcctac agtgccaatc     3180

gaatacagca aaggcttcag caagaagcgt atcgatcaca gacaccacgc cctggatgct     3240

ctggttatcg cctgcgccac caaggaccac gtgaacctgc tgaacaacca gtctgccaag     3300

agcgacacca agagatacga cttaaagaaa aaaagtatga aattcgagaa agtggtgtac     3360

aatgatgcca agaccggcga aaagatcgag cgggaagtgc ccaagcagtt cctgaagcct     3420

tgggagaact tcaccctgga tgtgaagcac aacctggaaa cgatcatcgt ctcttttaaa     3480

caaaatctgc gggtgatcaa taaagccacg aactactacg agaagtacgt cgagaaggac     3540

ggcaccaaaa acaaagagcg cgtggagcag acagggacaa actgggccat tagaaagccc     3600

atgcacaagg atacagtgtc cggcaaagtg gaccttcctt gggtgaaggt gcctaaggga     3660

aagatcctga ccgccacacg gaagagcttg gatagcagct tcgacctcaa gagcatcggc     3720

tctataacag atacaggcat tcagaagatc ctaaagaatt acctggcatt caaggacggc     3780

aaccctgagc tggctttcag ccctgagggc atcgacgatc tgaacaagaa catagagaag     3840

tacaacgatg gcaaacctca ccagcctatc aacaaggtgc gagtgtttga gctgggcagc     3900

aagttccagg tgggacaatc tggtaacaag aaggacaagt atgtggaagc tgctaagggc     3960

accaatctct tcttcgccgt gtacgaggat gaaaaaggaa agcggaacta cgagaccatc     4020

cctctcaacg aggtgatcga gagacagaag cagggcctga gcgtggtgga cctgaagggt     4080

acaaacgact tctacctgtg ccctaacgac tttgtgtaca tcccaagcgg cgacgagctg     4140

gaaaacatca acaacgtgga cttcaaggac atcaagaagg agattaacga gcgcatctac     4200

aaagtggtgt cttttacagg caatagactt tcttgtatcc cttacatggt ggccacaacg     4260

atcgtcaaca aactcgaatt cactcaactg aacaaaatcg agtttaccaa ggaaaaagaa     4320

atttgtatca agctcaacgt ggacagactg ggcaatatct ccaaggcc                  4368


<210> 134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SV40 large T-antigen nuclear localization sequence"

<400> 134
cctaagaaga aaagaaaggt g                                                 21


<210> 135
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Triple FLAG epitope tag"

<400> 135
gactacaagg accacgacgg cgactacaaa gatcacgata tcgactacaa ggacgacgat       60

gataag                                                                  66


<210> 136
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Nucleoplasmin nuclear localization sequence"

<400> 136
aaaagacctg ccgctacaaa gaaggccggc caggccaaga aaaagaag                    48


<210> 137
<211> 203
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Cytomegalovirus mammalian transcription promoter"

<400> 137
tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc       60

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact      120

ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt      180

gggaggtcta tataagcaga gct                                              203


<210> 138
<211> 304
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Cytomegalovirus transcription enhancer"

<400> 138
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210> 139
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Human U6 RNA promoter"

<400> 139
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacacc                                                    318


<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 189"

<400> 140
cctgaatgct gtgcggctct                                                   20


<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 185"

<400> 141
ggacagtgcg catctccctg                                                   20


<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 168"

<400> 142
cacatctcga gcaagacgtt                                                   20


<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 135"

<400> 143
gggccattaa aacctctcca                                                   20


<210> 144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 139"

<400> 144
aggttttaat ggcccagcct                                                   20


<210> 145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 143"

<400> 145
catggcagta cattagagca                                                   20


<210> 146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 190"

<400> 146
cctgaatgct gtgcggctct                                                   20


<210> 147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 194"

<400> 147
gccgcacagc attcaggtcg                                                   20


<210> 148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 165"

<400> 148
atggggaatg tagcaagacc                                                   20


<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 169"

<400> 149
cacatctcga gcaagacgtt                                                   20


<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 173"

<400> 150
cttctatagc ctccttcccc                                                   20


<210> 151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 144"

<400> 151
catggcagta cattagagca                                                   20


<210> 152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 136"

<400> 152
gggccattaa aacctctcca                                                   20


<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 145"

<400> 153
catggcagta cattagagca                                                   20


<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 188"

<400> 154
ggacagtgcg catctccctg                                                   20


<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 192"

<400> 155
cctgaatgct gtgcggctct                                                   20


<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 196"

<400> 156
gccgcacagc attcaggtcg                                                   20


<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 167"

<400> 157
atggggaatg tagcaagacc                                                   20


<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 171"

<400> 158
cacatctcga gcaagacgtt                                                   20


<210> 159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 175"

<400> 159
cttctatagc ctccttcccc                                                   20


<210> 160
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 197"

<400> 160
cctcaccccc acgagcttgt aggaa                                             25


<210> 161
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 199"

<400> 161
acagtgcgca tctccctggt cacca                                             25


<210> 162
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 146"

<400> 162
ggctgggcca ttaaaacctc tccag                                             25


<210> 163
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 148"

<400> 163
gaggctgggc cattaaaacc tctcc                                             25


<210> 164
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 176"

<400> 164
gaggctgaga caggagagtt gcttg                                             25


<210> 165
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 177"

<400> 165
cccacaaacc gatgtagctc aagag                                             25


<210> 166
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 209"

<400> 166
tagggtctta ctctgttgtc cacgc                                             25


<210> 167
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 151"

<400> 167
ttctcccgag ccaagtacac gtttc                                             25


<210> 168
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="target for Guide 152"

<400> 168
gaaaatctgc tcttagggct caagg                                             25


<210> 169
<211> 3210
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05083.1 Soy optimized"

<400> 169
atgagagagc tagattacag gatcggactc gatatcggaa ctaattcaat cgggtgggga       60

ataattgagc tgtcctggaa taaagatcgc gagcaatatg aaaaggctag gattgtggat      120

aagggagtga ggatgttcga taaggctgaa attcctaaga ctggagcttc tcttgctgaa      180

ccaagaagaa ttgctagatc tagcaggagg agattaaaca ggaagtctca gcgcaagaag      240

gatataagga accttctcgt tcagcatgaa atcatttctc agaaggagct tgcttctctc      300

taccctctaa ccaaatcaag catggacatc tgggatataa ggcttgatgg actcgatagg      360

cttcttgata gatttgagtg gaccaggctt ctaatacacc ttgctcaaag aaggggcttc      420

aaatcaaacc gcaagtccga attaaaggat gttgagactg gaaaggtgct ttcaagcatc      480

caagctaatg aaaagaggct ttctttgtac aggactgttg gggagatgtg gatgaaaaac      540

gaggacttct caaaatacga taaaaggagg aactcctcca acgagtacgt gttctctgtt      600

tctagggctg atcttgagaa ggagattgtg actctttttg aggctcaacg caagttccaa      660

tcaagctacg cttctgctga tcttcaaaag acctaccttc aaatttgggc tcatcagctt      720

ccttttgctt ctggaaacgc cattgtgaat aaagtgggat actgctccct attaaaggga      780

aaggagaaga gagtgcctaa ggctacctat acattccagt acttctctac cctcgatcaa      840

atcaatagaa ctaggcttgg acctaacttc cagcctttta ctaaggagca gagggatgtg      900

atcctcgatg aaatgttcaa caggaccgac tactataaaa agaagaccat tcccgaggtg      960

acctactacg atataagaaa gtggcttgct ctcgatgaaa ccattcagtt caagggacta     1020

acttatgacc ccaacgagga gctgaagaaa atagaactca agtccttcat aaacctcaag     1080

cccttctacg aaatcaagaa ggtggtaacc aactacgcca agaagaccaa cgaagcattc     1140

tctaccctcg attacgatac attcgcttac gctcttaccg tgtataaaac cgacaaggat     1200

ataaggtcct acctcaagaa atcaaacaac ctctccaagt gctgctacga cgatcaatta     1260

attgaggagc ttctcaccct ctcctatact aagttcggac acctctcttt caaggcaatc     1320

aaccatgtgc ttccaataat gcaagaggga agaacttacc aagaggcaat acaccaactt     1380

ggatacgatg ctaccaacct taagaaggag aacaggtcta tgttccttcc tctcttccct     1440

gatgagatta ctaaccctat tgtgaagaga gctttgactc aagctaggaa ggtggtgaat     1500

gctattatta ggaggtacgg atcacctaac tctgtgcata ttgagcttgc tagggagctt     1560

tctaagtctc atgatgagag gaccaagatt atgaaggctc acgatgagaa ctacaagaag     1620

aacaaggggg ctatttccat tctcattgag aacggaattc ttaaccctac cggatacgat     1680

attgtgaggt acaagttgtg gaaggagcaa ggagagagat gcgcttactc tcttaagcaa     1740

attcctgcta acaccttctt caacgagatg aagaaggaaa gatcaggatc tcctgtgctt     1800

gagattgatc acattctccc ttactcccag tccttcattg attcttacca caacaaggtg     1860

cttgtttacg gagatgagaa ccaaaagaag gggaacagga ttccttacac ttacttcctt     1920

gagggaaaca aggattggga gtctttcgag tcttacgtga ggcttaactc cttcttctct     1980

aagaagaaga ggggatacct tcttaagaag gcttatcttc ctagggagtc caatatgatt     2040

aaggagaggc acctaaacga taccaggtac gcttcttctt acctcaagaa cttcatcgag     2100

aagaacctta agttcaagga ggttgaggga tctactagga agaagcatgt tcagaccgtg     2160

aacggaatta ttactgctca tcttagaaag aggtggggac ttgagaagga taggcaagag     2220

acttaccttc atcacgctat ggatgctatt attgtggctt gcactgatca ccatatggtg     2280

actaaggtta ccgagtacta ccagattaag gagtcaaaca agtccatcag gaagccttat     2340

tttcctcttc cttgggttgg attcagggag gagattcttt ctcatcttgc tagacaacct     2400

atcgctagaa agatttccga ggagcttaag attggatacc agtccttcga ttacattctt     2460

gtgtctagga tgcctaagag gtctgttact ggagctgctc atgagcagac tattatgaag     2520

aagggaggaa ttgataagaa ggggaagacc atcatcatta agagggtgta cctaaaggac     2580

atcaagttcg atgagaacgg ggatttcaag atggttggaa aggagcagga tcttgctact     2640

tacgaggcta ttaagcagag gtacattgag tatggaaagg agtctaagaa ggctttcgag     2700

actcctcttt acaagccttc taagaaggga aaggggaacc tcatcaagaa gattaaggtt     2760

gaggttcaga ctaagtcttt cgttagggag gttaatggag gagttgctca gaatggagat     2820

cttgtgaggg ttgatctatt cgagaaggac aacaggtact acatgatccc tatctacgtg     2880

atggatactg ttcattccga gcttcctaac aaggctgtta cttcttctaa gggatacgag     2940

cagtggctta ccattgataa ctctttcacc ttcaagttct ctctctaccc ttacgatctt     3000

gttaggcttg ttaagggaaa cgaggatagg ttcctctact tctccaccct cgatattaac     3060

tctgataggc tcaacttcaa ggatgtgaac aagccttcaa agcaagctga gaacaggtac     3120

tctcttaaga ccattgagaa ccttgagaag tacgaagtgg gagttcttgg agatcttagg     3180

ttcgttaggc aagagattag gaagaacttc                                      3210


<210> 170
<211> 3210
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05083.1 Corn optimized"

<400> 170
atgcgcgagc tagattacag gatcggcctg gatatcggca ctaactcaat aggctggggc       60

atcatcgagc tgagctggaa taaagaccgc gagcagtatg aaaaggccag gatcgtggac      120

aagggcgtga ggatgttcga taaggccgag atcccaaaga caggcgcctc tctggccgaa      180

ccaaggagga tcgccaggtc ttctaggagg agattaaaca ggaagtctca gcgcaagaag      240

gatataagga acctgctggt ccagcatgaa atcatctctc agaaggagct ggccagcctg      300

tacccgctga ccaagtcaag catggacatc tgggatataa ggctggatgg cctggatagg      360

ctgctggata ggttcgagtg gacaaggctg ctgatacatc tggcccagag gaggggcttc      420

aaatcaaata ggaagagcga attaaaggac gtggagacag gcaaggtgct gtcaagcatt      480

caggccaatg aaaagcgcct gagcctgtac aggacagtgg gcgagatgtg gatgaaaaac      540

gaggacttct caaaatacga caagcgccgc aacagcagca acgagtacgt gttcagcgtg      600

agcagggccg acctggagaa ggagatcgtg acactgttcg aggcccagag gaagttccaa      660

tcaagctacg cctctgccga tctgcagaag acatacctgc agatctgggc ccaccagctg      720

ccattcgcta gcggcaatgc catcgtgaat aaagtgggct actgctctct attaaagggc      780

aaggagaaga gggtgccaaa ggccacctat acattccagt acttcagcac cctggaccaa      840

atcaatagga cacgcctggg cccaaacttc cagccattca caaaggagca gcgcgacgtg      900

atcctggatg aaatgttcaa ccgcaccgac tactataaaa agaagaccat cccggaggtg      960

acatactacg atataaggaa gtggctggcc ctggatgaaa ccatccagtt caagggccta     1020

acctacgacc cgaacgagga gctgaagaaa atagaactga agagcttcat aaacctgaag     1080

ccgttctacg aaatcaagaa ggtggtaacc aactacgcca agaaaaccaa cgaagcattc     1140

agcaccctgg actacgatac attcgcctac gccctgaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaagaa atcaaacaac ctgagcaagt gctgctacga cgaccaatta     1260

atcgaggagc tgctgaccct gagctatact aagttcggcc acctgagctt caaggcaatc     1320

aaccacgtgc tgccaataat gcaggagggc cgcacctacc aggaggcaat acaccagctg     1380

ggctacgacg caaccaacct gaagaaggag aaccgaagca tgttcctgcc gctgttcccg     1440

gacgagatca ccaacccgat cgtgaagcgc gccctgaccc aggcccgcaa ggtggtgaac     1500

gccatcatcc gccgctacgg ctcaccgaac agcgtgcaca ttgagctggc ccgcgagctg     1560

agcaagagcc acgacgagcg cacaaagatc atgaaggccc acgacgagaa ctacaagaag     1620

aacaagggcg ccatcagcat cctgatcgag aacggcatcc tgaacccaac aggctacgac     1680

atcgtgaggt acaagctgtg gaaggagcag ggcgagaggt gcgcctactc tctgaagcag     1740

atcccagcca atacattctt caacgagatg aagaaggaga ggtcaggctc tccagtgctg     1800

gagattgatc acatcctgcc atacagccag agcttcatcg acagctacca caacaaggtg     1860

ctggtgtacg gcgatgagaa ccagaagaag ggcaatcgca tcccatacac atacttcctg     1920

gagggcaaca aggattggga gagcttcgag agctacgtga ggctgaacag cttcttcagc     1980

aagaagaaga ggggctacct gctgaagaag gcctacctgc caagggagag caacatgatc     2040

aaggagaggc acctaaacga tacaaggtac gccagcagct acctgaagaa cttcatcgag     2100

aagaacctga agttcaagga ggtggagggc agcacccgta agaagcacgt ccagaccgtg     2160

aacggcatca tcacagccca cctgaggaag aggtggggcc tggagaagga taggcaggag     2220

acatacctgc atcacgccat ggatgccatc atcgtggctt gcacagatca ccacatggtg     2280

acaaaggtga cagagtacta ccagatcaag gagagcaaca agtcaatccg caagccatac     2340

ttcccactgc catgggtggg cttcagggag gagatcctgt ctcacctggc caggcagcca     2400

atcgccagga agatctctga ggagctgaag atcggctacc agtctttcga ttacatcctg     2460

gtgtctagga tgccaaagag gtctgtgaca ggcgccgccc acgagcagac aatcatgaag     2520

aagggcggca tcgataagaa gggcaagaca atcatcatca agagggtgta cctgaaggat     2580

atcaagttcg atgagaacgg cgatttcaag atggtgggca aggagcagga tctagccaca     2640

tacgaggcca tcaagcagag gtacatcgag tacggcaagg agtctaagaa ggccttcgag     2700

acaccactgt acaagccatc taagaagggc aagggcaacc tgatcaagaa gatcaaggtg     2760

gaggttcaga ccaagagctt cgtgagggag gtgaatggcg gcgtggccca gaatggcgat     2820

ctggtgaggg tggatctgtt cgagaaggat aacaggtact acatgatccc gatctacgtg     2880

atggatacag tgcacagcga gctgccaaac aaggccgtga catcttctaa gggctacgag     2940

cagtggctaa ccatcgacaa cagcttcacc ttcaagttca gcctgtaccc atacgacctg     3000

gtgaggctgg tgaagggcaa tgaggacagg ttcctgtact tcagcaccct ggacatcaac     3060

agcgacaggc tgaacttcaa ggacgtgaac aagccatcta agcaggccga gaacaggtac     3120

agcctgaaga ccatcgagaa cctggagaag tacgaggtgg gcgtgctggg cgatctgagg     3180

ttcgtgaggc aggagatcag gaagaatttc                                      3210


<210> 171
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07433.1 Soy optimized"

<400> 171
atgagagagc tagattacag gatcggactc gatatcggaa ctaattcaat tggatggggc       60

gtgattgagc tttcctggaa taaagatagg gagcgttatg aaaaggttag gattgtggat      120

cagggagtta ggatgtttga tagagctgag atgcctaaga ctggagcttc attagctgaa      180

ccaagaagga ttgctagatc tagcaggagg agattaaaca ggaagtctca gcgcaagaag      240

aatataagga accttcttgt tcagcacgga gttattactc aggaggagct tgattctctc      300

taccctctct ccaagaaatc aatggatatc tggggaatta ggcttgatgg actcgatcgc      360

ctattaaacc attttgagtg ggctaggctt ctaatacacc ttgctcaaag aaggggcttc      420

aaatcaaacc gcaagtccga attaaaggat actgagactg gaaaggtgct ttcaagcatc      480

cagctcaatg aaaagaggct ttctttgtat aggactgttg gggagatgtg gatgaaagat      540

cccgacttct caaaatacga taggaagagg aactctccta acgagtacgt gttttctgtt      600

tctagagctg agcttgagaa ggagattgtg actttgtttg ctgctcaaag gaggttccaa      660

tctccttacg cttctaagga tcttcaagag acctaccttc agatttggac tcatcagctt      720

ccttttgctt ccgggaacgc tattctcaat aaagtgggat actgctcctt attaaaggga      780

aaggagagaa ggattcctaa ggccacctat acattccagt acttctctgc tcttgatcaa      840

gtgaatagaa ctaggcttgg acctgatttc cagcctttta ctaaggagca gcgcgagatc      900

atcctcaata atatgttcca gaggaccgac tactataaaa agaagaccat tcccgaggtg      960

acctactacg atataagaaa gtggcttgag cttgatgaaa ccattcagtt caagggatta     1020

aactacgacc ccaacgagga gctgaagaaa atagagaaga agcccttcat aaacctcaag     1080

gccttctacg aaatcaacaa ggtggtggct aactactctg agcgaaccaa tgaaaccttc     1140

tctaccctcg attacgatgg aattggatac gctcttaccg tgtataaaac cgacaaggat     1200

ataaggtcct acctcaaatc aagccataat ctccctaaga ggtgctacga cgatcaatta     1260

attgaggagc ttctctccct ctcctatact aagttcgggc acctctctct taaggcaatc     1320

aaccatgttc taagcattat gcagaagggg aacacatata aggaggctgt tgatcagctt     1380

ggatacgata cttctggact taagaaggag aagaggtcta agttcctccc tcctatttct     1440

gatgagatta ccaaccctat tgtgaagaga gctttgactc aagctaggaa ggtggtgaat     1500

gctattatta ggaggcatgg atctcctcat tctgtgcata ttgagcttgc tagggagctt     1560

tcaaagaatc acgatgagag gactaagatt gtttctgctc aggacgagaa ctacaagaag     1620

aacaaggggg ctatttctat tctctctgag cacggaattc ttaaccctac cggatacgat     1680

attgtgaggt ataagttgtg gaaggagcaa ggagagagat gcgcttactc tcttaaggaa     1740

attcctgctg ataccttctt caacgagctt aagaaggaaa ggaacggtgc tcctattcta     1800

gaggtggatc acattcttcc ttactcccag tccttcattg attcttacca taacaaggtg     1860

cttgtgtatt ccgatgagaa caggaagaag ggaaacagga ttccttacac ctacttcctt     1920

gagactaata aggattggga ggcttttgag aggtacgtga ggtctaacaa gttcttctct     1980

aagaagaaga gggagtacct tcttaagagg gcttatcttc ctagggagtc agagcttatt     2040

aaggagaggc atcttaacga taccaggtac gcttctacct tcctcaagaa cttcattgag     2100

cagaaccttc aattcaagga agctgaggat aatcctagaa agaggagggt tcagactgtg     2160

aacggagtta ttactgctca ttttagaaag aggtggggac ttgagaagga taggcaagag     2220

acttaccttc atcacgctat ggatgctatt attgtggctt gcactgatca tcatatggtg     2280

actagggtta ccgagtacta ccagatcaag gagtcaaaca agtctgtgaa gaagccttat     2340

tttcctatgc cttgggaagg attcagggat gagcttcttt ctcatcttgc ttctcagcct     2400

atcgctaaga agatttctga agagcttaag gctggatacc agtcccttga ttacattttc     2460

gtgtctagaa tgcctaagag gtctattact ggagctgctc acaagcagac tattatgagg     2520

aagggaggaa ttgataagaa ggggaagacc atcattattg agaggctcca cctcaaggat     2580

atcaagttcg atgagaacgg agatttcaag atggttggaa aggagcagga tatggctact     2640

tacgaggcta ttaagcagag atatctagag cacggaaaga actctaagaa ggctttcgag     2700

actcctcttt acaagccttc taagaaggga accggaaacc ttattaagag agttaaggtt     2760

gagggacagg ctaagtcttt cgttagagag gttaatggag gagttgctca gaatggagat     2820

cttgtgaggg ttgatctttt cgagaaggac gataagtact acatggtgcc tatctacgtt     2880

cctgatactg tttgttccga gcttcctaag aaggttgttg cttcttctaa gggatacgag     2940

caatggctta cccttgataa ctctttcacc ttcaagttct ctctctaccc ttacgatctt     3000

gttaggctag ttaagggaga tgaggatagg ttcctttact tcgggaccct cgatattgat     3060

tctgataggc tcaacttcaa ggatgtgaac aagccttcta agaagaacga gtacaggtac     3120

tctctcaaga ccattgagga tcttgagaag tacgaagtgg gagttcttgg agatcttaga     3180

cttgttagaa aggagactag gaggaacttc cac                                  3213


<210> 172
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07433.1 Corn optimized"

<400> 172
atgcgcgagc tagattacag gatcggcctg gatatcggca ctaactcaat cggctggggc       60

gtgatcgagc tgagctggaa taaagatcgc gagcgctatg aaaaggtgcg catcgtggat      120

cagggcgtta ggatgttcga tagggccgag atgccaaaga caggcgcctc actggccgaa      180

ccaaggagga tagccaggtc ttctaggagg agattaaaca ggaagtctca gcgcaagaaa      240

aatatcagga acctgctggt tcagcacggc gtgatcacac aggaggagct ggattctctg      300

tacccactga gcaagaaaag catggacatc tggggcatta ggctagatgg cctggaccgc      360

ctattaaacc acttcgagtg ggcccgccta ttaattcacc tggcccagag gaggggcttc      420

aaatcaaata ggaagagcga attaaaggac accgagacag gcaaggtgct gtcaagcatc      480

cagctgaatg aaaagcgcct gagcctgtac aggacagtgg gcgagatgtg gatgaaagac      540

ccggacttct caaaatacga ccgcaagcgc aacagcccga acgagtacgt gttctctgtg      600

tctagggccg agctggagaa ggagatcgtg acactgttcg ccgctcagag gaggttccag      660

tctccatacg cctctaagga tctgcaagag acatacctgc agatctggac acaccagctg      720

ccattcgcct ctggcaatgc catcctgaat aaagtgggct actgctctct attaaagggc      780

aaggagagga ggattccaaa ggccacctat acattccagt acttcagcgc cctggaccag      840

gtgaatagga caaggctggg cccagatttc cagccattca caaaggagca gcgcgagatc      900

atcctgaata atatgttcca gcgcaccgac tactataaaa agaagaccat cccggaggtg      960

acatactacg atataaggaa gtggctggag ctggatgaaa ccatccagtt caagggatta     1020

aactacgacc cgaacgagga gctgaagaaa atagagaaga agccgttcat aaacctgaag     1080

gccttctacg aaatcaacaa ggtggtggcc aactacagcg agcgaaccaa cgagaccttc     1140

agcaccctgg actacgacgg catcggctac gccctgaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaaatc aagccacaac ctgccgaagc gctgctacga cgaccaatta     1260

atcgaggagc tgctgagcct gagctatact aagttcggcc acctgagcct gaaggcaatc     1320

aaccacgtgc taagcatcat gcagaagggc aatacataca aggaggccgt ggaccagctg     1380

ggctacgaca ccagcggcct gaagaaggag aagcgcagca agttcctgcc gccgatcagc     1440

gacgagatca ccaacccgat cgtgaagcgc gccctgaccc aggccaggaa ggtggtgaac     1500

gccatcatca ggaggcacgg ctctccacat agcgtgcaca tcgagctggc cagggagctg     1560

tctaagaatc acgatgagag gacaaagatc gtgtcagccc aggacgagaa ctacaagaag     1620

aataagggcg ccatctctat cctgtctgag cacggcatcc tgaacccaac aggctacgac     1680

atcgtgaggt acaagctgtg gaaggagcag ggcgagaggt gcgcctactc tctgaaggag     1740

atcccagccg atacattctt caatgagctg aagaaggaga ggaatggcgc cccaatcctg     1800

gaggtggatc acatcctgcc atactctcag agcttcatcg attcatacca caacaaggtg     1860

ctggtgtaca gcgacgagaa caggaagaag ggcaatcgca tcccatacac atacttcctg     1920

gagaccaaca aggattggga ggccttcgag aggtacgtgc gcagcaacaa gttcttcagc     1980

aagaagaagc gcgagtacct gctgaagagg gcctacctgc ctagggagtc tgagctgatc     2040

aaggagaggc acctgaatga tacaaggtac gccagcacct tcctgaagaa cttcatcgag     2100

cagaacctac agttcaagga ggccgaggat aacccaagga agaggagggt tcagacagtg     2160

aatggcgtga tcacagccca cttcaggaag aggtggggcc tggagaagga taggcaggag     2220

acatacctgc atcacgccat ggatgccatc atcgtggctt gcacagatca ccacatggtg     2280

acaagggtga cagagtacta ccagatcaag gagagcaaca agagcgtgaa gaagccatac     2340

ttcccaatgc catgggaggg cttcagggat gagctactgt ctcacctggc ctctcagcca     2400

atcgccaaga agatctctga ggagctgaag gccggctacc agtctctgga ttacatcttc     2460

gtgtctagga tgccaaagag gtctatcaca ggcgccgccc acaagcagac aatcatgagg     2520

aagggcggca tcgataagaa gggcaagaca atcatcatcg agaggctgca tctgaaggac     2580

atcaagttcg atgagaacgg cgatttcaag atggtgggca aggagcagga tatggccaca     2640

tacgaggcca tcaagcagcg ctacctagag cacggcaaga actctaagaa ggccttcgag     2700

acaccactgt acaagccatc taagaagggc accggcaatc tgatcaagag ggtgaaggtg     2760

gagggccagg ccaagtcttt cgtgagggag gtgaatggcg gcgtggccca gaatggcgat     2820

ctggtgaggg tggatctgtt cgagaaggat gataagtact acatggtgcc aatctacgtg     2880

ccagatacag tgtgctctga gctgccaaag aaggtggtgg cctcttctaa gggctacgag     2940

cagtggctaa cactggataa cagcttcaca ttcaagttca gcctgtaccc atacgatctg     3000

gtgaggctgg tgaagggcga tgaggatagg ttcctgtact tcggcacact ggatatcgat     3060

agcgacaggc tgaacttcaa ggacgtgaac aagccgagca agaagaacga gtaccgctac     3120

agcctgaaga caatcgagga cctggagaag tacgaggtgg gcgtgctggg cgatctgagg     3180

ctggtgagga aggagacaag gaggaatttc cac                                  3213


<210> 173
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07513.1 Soy optimized"

<400> 173
atgagagagc tagattacag gatcggactc gatatcggaa ctaattcaat tggatggggc       60

gtgattgagc tttcctggaa taaagatcgc gagcaatatg aaaagaccag gattgtggat      120

aagggagtga ggatgttcga taaggctgaa attcctaaga ctggagcttc tcttgctgaa      180

ccaagaagaa ttgctagatc tagcaggagg agattaaaca ggaagtctca gcgcaagaag      240

gatataagga accttctcgt tcagcatgaa atcatttccc agaaggaatt aacctctctc      300

taccctctct ccaaatcaag catggacatc tgggatataa ggcttgatgg actcgatagg      360

cttcttgata gatttgagtg ggctaggctt ctaatacacc ttgctcaaag aaggggcttc      420

aaatcaaacc gcaagtccga attaaaggat gttgagactg gaaaggtgct ttcaagcatc      480

caggtgaatg aaaagaggct ttctttgtat aggactgttg gggagatgtg gatgaaaaac      540

gccgattgct caaaatatgg aaagaggagg aactctccta acgagtacgt gttttctgtt      600

tctagggctg atcttgagaa ggagattgtg actctttttg aggctcagag gaagttccac      660

tcttcttacg cttctgtgga tctccaaaag acatacattc agatttgggc tcatcagctt      720

ccttttgctt ctggaaacgc cattgtgaat aaagtgggat actgctccct attaaaggga      780

aaggagaaga gagtgcctaa ggctacctat acattccagt acttcaatac cctcgatcaa      840

atcaacagaa ctaggcttgg acctaacttc cagcctttta ctaaggagca gagggatata      900

atcctcgata aaatgttcca gcgcaccgac tactataaaa agaagaccat ccccgaggtg      960

acctactacg atataagaaa gtggcttgct ctcgatgaaa ccattcagtt caagggacta     1020

acttatgacc ccaacgagga gctgaagaaa atagagatga aacccttcat aaacctcaag     1080

cccttctacg aaatcaagaa ggtggtaacc aactacgcca agaaaaccaa cgaggtgttc     1140

tctgctcttg attacgatac tgtggcttac gctcttaccg tgtataaaac cgacaaggat     1200

ataaggtctt acctcaagcg ctccaataat ctctctaaga ggtgctacga cgatcaatta     1260

attgaggagc ttctcaccct ctcctatact aagttcggac acctctcttt caaggcaatc     1320

aaccatgtgc ttccaataat gcaagaggga agaacttacc aagaggcaat acaccagctt     1380

ggatacgata caaccaacct caagaaggag aatagaagca tgttcctccc aatcatccct     1440

gatgaaataa ccaaccctat tgtgaagaga gctttgactc aagctaggaa ggtggtgaat     1500

gcaataatta ggaggtacgg atcacctaac tctgtgcata ttgagcttgc cagggaatta     1560

agcaagtctc atgatgagag gaagaagatt atgactgctc acgacgagaa ctacaagaag     1620

aacaagggag ctgtgtccat tctcattgat aacggaattc ttaaccctac cggatacgat     1680

attgtgaggt acaagttgtg gaaggagcaa ggagagagat gcgcttactc tcttaagaag     1740

attcctgcta acaccttctt caacgagctt aagaaggaaa gatctggacc tcctgttctt     1800

gaggtggatc acattctacc ttactcccag tccttcattg attcttacca taacaaggtg     1860

cttgtttacg gagatgagaa ccaaaagaag gggaacagga ttccttacac tttcttctct     1920

gaagaagata aggagtggga gtctttcgag tcttacgtga ggtccaactc cttcttctct     1980

aagaagaaga ggggatacct tcttaagaag gcttatcttc ctagggagtc taaccttatt     2040

aaggagaggc accttaacga taccaggtac gcttcatctt acctcaagaa cttcatcgag     2100

aagaacctta agttcaagga ggctgtggga attactagga agaagtacgt tcagactgtg     2160

aacggagtga ttactgctca tcttagaaag agatggggac ttgagaagga taggcaagag     2220

acttaccttc atcacgctat ggatgctatt attgtggctt gcactgatca ccatatggtg     2280

actaaggtta ccgagtacta ccaaattaag gaggggaaca agtccatcaa gaagccttat     2340

tttcctctac cttggatggg attcagggag gagattcttt ctcatcttga gtctcaacct     2400

atcgctagaa agatttccga ggagcttaag attggatacc agtcccctga ttacattctt     2460

gtgtctagaa tgcctaagag gtctgttact ggatctgctc atgatcagac tgtgatgaag     2520

aagggggata ttgataagaa ggggaagacc atcattatta agagggtgca cctcaaggac     2580

atcaagttcg atgagaacgg agatttcaag atggttggaa aggagcagga tctagctact     2640

tacgaggcta ttaagcagag gtatcttgag tataggaagg agtctaagaa ggctttcgag     2700

actcctcttt acaagccttc taagaaggga aaggggaacc tcatcaagaa gattaaggtt     2760

gaggttcaga ctaagtcttt cgtgagggag attaatggag gagttgctca gaatggagat     2820

cttgtgaggg ttgatctttt cgagaaggac aacaggtact acatggtgcc tatctacgtt     2880

gttgatactg ttaggtctga gctacctaac aaggctgtta cttcttctaa gggatacgag     2940

cagtggctct ctattgataa ctctttcacc ttcaagttct ctctctaccc ttacgatctt     3000

gttaggcttg ttaagggaga tgaggatagg ttcctctact tctccaccct cgatattaac     3060

tctgataggc tcaacttcaa ggatgtgaac aagccttcta agcaagctga gtacaggtac     3120

tctcttaaga ccattgagaa ccttgagaag tacgagattg gagttcttgg agatctaagg     3180

cttgttaggc aggagaccag gaagattttc aag                                  3213


<210> 174
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07513.1 Corn optimized"

<400> 174
atgcgcgagc tagattacag gatcggcctg gatatcggca ctaactcaat cggctggggc       60

gtgatcgagc tgagctggaa taaagatcgc gagcagtatg aaaagaccag gatcgtggac      120

aagggcgtga ggatgttcga taaggccgag atcccaaaga caggcgcctc tctggccgaa      180

ccaaggagga tcgccaggtc ttctaggagg agattaaaca ggaagtctca gcgcaagaag      240

gatataagga acctgctggt ccagcatgaa atcatcagcc agaaggagct gacaagcctg      300

tacccgctga gcaagtcaag catggacatc tgggatataa ggctggatgg cctggatagg      360

ctgctggata ggttcgagtg ggccaggctg ctgatacatc tggcccagag gaggggcttc      420

aaatcaaatc gcaagagcga attaaaggac gtggagacag gcaaggtgct gtcaagcatt      480

caggtgaatg aaaagaggct gagcctgtac aggacagtgg gcgagatgtg gatgaaaaac      540

gccgactgct caaaatacgg caagcgccgc aacagcccaa acgagtacgt gttctctgtg      600

tctagggccg atctggagaa ggagatcgtg acactgttcg aggcccagag gaagttccac      660

tcttcttacg cctctgtgga cctgcagaag acatacatcc agatctgggc ccaccagctg      720

ccattcgcct ctggcaatgc catcgtgaat aaagtgggct actgctctct attaaagggc      780

aaggagaaga gggtgccaaa ggccacctat acattccagt acttcaatac cctggaccaa      840

atcaacagga cccgcctggg cccaaacttc cagccattca caaaggagca gcgcgatata      900

atcctggata aaatgttcca gcgcaccgac tactataaaa agaagaccat cccggaggtg      960

acatactacg atataaggaa gtggctggcc ctggatgaaa ccatccagtt caagggccta     1020

acctacgacc cgaacgagga gctgaagaag atcgagatga aaccgttcat aaacctgaag     1080

ccgttctacg aaatcaagaa ggtggtaacc aactacgcca agaaaaccaa cgaggtgttc     1140

agcgccctgg actacgacac cgtggcctac gccctgaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaagcg cagcaataat ctgagcaagc gctgctacga cgaccaatta     1260

atcgaggagc tgctgaccct gagctatact aagttcggcc acctgagctt caaggcaatc     1320

aaccacgtgc tgccaataat gcaggagggc cgcacctacc aggaggcaat acaccagctg     1380

ggctacgaca caaccaacct gaagaaggag aaccgaagca tgttcctgcc aataatcccg     1440

gacgagataa ccaacccgat cgtgaagcgc gccctgaccc aggcccgcaa ggtggtgaac     1500

gcaataatcc gccgctacgg ctcaccgaac agcgtgcaca ttgagctggc ccgcgaatta     1560

agcaagagcc acgacgagcg caagaagatc atgaccgccc acgatgaaaa ctacaagaaa     1620

aataagggcg ccgtgagcat cctgatcgac aacggcatcc tgaacccgac cggctacgac     1680

atcgtgcgct acaagctgtg gaaggagcag ggcgagaggt gcgcctactc tctgaagaag     1740

atcccagcca acaccttctt caacgagctg aagaaggaga ggtctggccc accagtgctg     1800

gaggtggatc acatcctgcc atactcacag agcttcatcg atagctacca caacaaggtg     1860

ctggtgtacg gcgatgagaa ccagaagaag ggcaatcgca tcccatacac attcttcagc     1920

gaggaggata aggagtggga gagcttcgag agctacgtga ggagcaacag cttcttcagc     1980

aagaagaaga ggggctacct gctgaagaag gcctacctgc caagggagtc taacctgatc     2040

aaggagaggc acctgaacga tacaaggtac gccagcagct acctaaagaa cttcatcgag     2100

aagaacctga agttcaagga ggccgtgggc atcacccgca agaagtacgt ccagacagtg     2160

aacggcgtga tcacagccca cctgaggaag aggtggggcc tggagaagga taggcaggag     2220

acatacctgc atcacgccat ggatgccatc atcgtggctt gcacagatca ccacatggtg     2280

acaaaggtga cagagtacta ccagatcaag gagggcaaca agagcatcaa gaagccatac     2340

ttcccactac catggatggg cttcagggag gagatcctgt ctcacctgga gtctcagcca     2400

atcgccagga agatctctga ggagctgaag atcggctacc agtctccaga ttacatcctg     2460

gtgtctagga tgccaaagag gtctgtgaca ggctctgccc acgatcagac agtgatgaag     2520

aagggcgata tcgacaagaa gggcaagacc atcatcatca agagggtgca cctgaaggac     2580

atcaagttcg acgagaacgg cgacttcaag atggtgggca aggagcagga tctagccaca     2640

tacgaggcca tcaagcagcg ctacctggag tacaggaagg agtctaagaa ggccttcgag     2700

acaccactgt acaagccatc taagaagggc aagggcaacc tgatcaagaa gatcaaggtg     2760

gaggtccaga ccaagagctt cgtgagggag atcaatggcg gcgtggccca gaatggcgat     2820

ctggtgaggg tggatctgtt cgagaaggat aacaggtact acatggtgcc aatctacgtg     2880

gtggatacag tgaggagcga gctaccaaac aaggccgtga catcttctaa gggctacgag     2940

cagtggctga gcatcgacaa cagcttcacc ttcaagttca gcctgtaccc atacgatctg     3000

gtgaggctgg tgaagggcga tgaggacagg ttcctgtact tcagcacact ggacatcaac     3060

agcgacaggc tgaacttcaa ggacgtgaac aagccatcta agcaggccga gtacaggtac     3120

agcctgaaga ccatcgagaa cctggagaag tacgagatcg gcgtgctggg cgatctaagg     3180

ctggtgaggc aggagacaag gaagatcttc aag                                  3213


<210> 175
<211> 3216
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG08290.1 Soy optimized"

<400> 175
atgtctgagc tagattacag gatcggactc gatatcggaa ctaattcaat tggatgggga       60

gtgattgagc ttttctggaa taaagatcgc gagcgctatg aaaaggttag gattgtggat      120

aagggagtga ggatgttcga taaggccgag attcctaata aaggagcttc acttgctgaa      180

ccaagaagga ttgctagatc tagcaggagg agattaaaca ggaagtctca gaggaagaag      240

gagattagga accttcttgt tcagcacgga atgattactc aggaggagct tgatcttctc      300

taccctctct ccaagaaatc aatcgatatc tgggatataa ggcttgatgg actcgatagg      360

ctattaaacc atcttgagtg ggctaggctt ctaatacacc ttgctcaaag aaggggcttc      420

aaatcaaacc gcaagtccga attaaaggat gctgagactg gaaaggttct ttcaagcatc      480

caggtgaatg aaaagaggct tttcttgtat aggactgtgg gcgagatgtg gataaaagat      540

gccgagttct caaaatatga taggaggagg aactctccta acgagtacgt gttttctgtt      600

tctagggctg atcttgagaa ggagattgtg actttgtttg aggctcaacg caagttccaa      660

tcaagctacg cttctaagaa ccttcaagag acctaccttc aaatttgggc tcatcagctt      720

ccttttgctt ccgggaacgc tattctcaat aaagtgggat actgctcctt attaaaggga      780

aaggagagaa ggattcctaa ggccacctat acattccagt acttctctgc tcttgatcaa      840

gtgaatagaa ctaggcttgg acctgatttc caacctttca ctcaggagca gaaggaaata      900

atcctcgata aaatgttcca gcgcaccgac tactataaaa agaagaccat ccccgaggtg      960

tcctactacg atataagaaa gtggcttgag cttgatgaaa ccattcagtt caagggatta     1020

aactacgacc ccaacgagga gctgaagaaa atagagaaga agcccttcat aaacctcaag     1080

gccttctacg aaatcaagaa ggtggttgct aactacgctg aacgaaccaa cgaagcattc     1140

tctaccctcg attacgatgc tattgcttac gctcttaccg tgtataaaac cgacaaggat     1200

ataaggtcct acctcaagaa atcaaacaac ctctccaaga ggtgctacga cgatcaatta     1260

atcgaggagc ttttcaccct ctcctatact aagttcggac acctctcttt caaggcaatc     1320

aaccatgtgc ttcctattat gcaagaggga agaacttacc aagaggctat tcatcagctt     1380

ggatacgata ccaccaacct taagaaggag aacaggtcta tgttcctccc tctcattcct     1440

gatgagatta ctaaccctat tgtgaagagg gctattactc aagctaggaa ggtggtgaat     1500

gctattatta ggaggtacgg atcacctaac tctgtgcata ttgagcttgc tagggagctt     1560

tctaagtctc atgatgagag gaagaagatt atgactgctc acgacgagaa ctacaagaag     1620

aacaaggggg ctatttccat tctcattgag aacggaattc ttaaccctac cggatacgat     1680

attgtgaggt acaagttgtg gaaggagcaa ggagagagat gcgcttactc tcttaaggaa     1740

attcctcctg ataccttctt caacgagctt aagaaggaga ggaacggatc acctattctt     1800

gaggtggatc acattcttcc ttactcccag tccttcattg attcttacca taacaaggtg     1860

cttgtgtatt ccgatgagaa caggaacaag ggaaacagga ttccttacac ctacttcctt     1920

gagactaata aggattggga ggcttttgag aggtatgtga ggtctaacaa gctcttctct     1980

aagaagaaga gggagtacct ccttaagaag acttaccttc ctagggagtc tgagcttatt     2040

aaggagaggc atctaaacga taccaggtac gcttctacct tcctcaagaa cttcattgag     2100

cagaaccttc aattcaagga ggttgaggtt aaccttagga agaagagggt tcagactgtg     2160

aacggagtta ttactgctca tcttagaaag agatggggac ttgagaagaa caggcaagag     2220

acttaccttc atcacgctat ggatgctatt attgtggctt gcactgatca tcacatggtg     2280

actaggatta ccgagtacta ccagattaag gagtcaaaca agtctgtgaa gaagccttat     2340

tttcctatgc cttgggaggg attcagggat gagcttcttt ctcatcttgc ttctcagcct     2400

atcgctaaga agatttctga agagcttaag gctggatacc agtcctctga ttacattttc     2460

gtgtctagaa tgcctaagag gtctgttact ggagctgctc atgatcaaac tattaggagg     2520

aagggaggaa ttgataagaa ggggaagacc atcattatta agagggtgag gctaaaggac     2580

atcaagttcg atgagaacgg ggatttcaag atggttggaa aggagcagga tcttgctact     2640

tacgaggcta ttaagcagag atatcttgag cacaggaaga actctaagaa ggctttcgag     2700

actcctcttt acaagccttc taagaaggga accggaaacc ttatcaagag agttaagatt     2760

gagggacaga ctaaggcttt cgttagagag gttaatggag gagttgctca gaactctgat     2820

cttgtgaggg ttgatctatt cgagaaggac gataagtact acatggtgcc tatctacgtt     2880

cctgatactg tttgttccga gcttcctaag aaggttgtta agtctggaaa gggatacgag     2940

caatggctta cccttgataa ctctttcacc ttcaagtctt ctctctaccc ttacgatctt     3000

gttaggcttg ttaagggaaa cgaggatagg ttcctttact tcgggaccct cgatattgat     3060

tctgataggc tcaacttcaa ggatgtgaac aagccttcaa agcaaaacga gtacaggtac     3120

tctctcaaga ccattgagaa ccttgagaag tacgaagtgg gagttcttgg agatcttagg     3180

cttgttaagc aagagaccag gaggattttc aatagg                               3216


<210> 176
<211> 3216
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG08290.1 Corn optimized"

<400> 176
atgtcagagc tggactacag gatcggcctg gacataggca ctaattcaat cggctggggc       60

gtgatcgagc tgttctggaa taaagaccgc gagcgctatg aaaaggtgcg catcgtggac      120

aagggcgtta ggatgttcga taaggccgag atcccgaata aaggcgcctc actagccgaa      180

ccaaggagga tcgccaggtc ttctaggagg agattaaaca ggaagtctca gaggaagaag      240

gagatcagga acctgctggt ccagcacggc atgatcacac aggaggagct ggatctgctg      300

tacccactga gcaagaaaag cattgacatc tgggacatca ggctagatgg cctggacagg      360

ctgctgaatc acctggagtg ggccaggctg ctgatacatc tggcccagag gaggggcttc      420

aaatcaaatc gcaagtctga attaaaggat gccgagacag gcaaggtgct gtcaagcatc      480

caggtgaatg aaaagaggct gttcctctac cgcacagtgg gcgagatgtg gataaaagac      540

gccgagttca gcaagtacga caggaggagg aacagcccaa acgagtacgt gttctctgtg      600

tcaagggccg atctggagaa ggagatcgtg acactgtttg aggctcagcg caagttccaa      660

tcaagctacg ccagcaagaa cctgcaagag acctacctgc agatctgggc ccaccagctg      720

ccattcgcta gcggcaatgc catcctgaat aaagtgggct actgctctct attaaagggc      780

aaggagagga ggattccaaa ggccacctat acattccagt acttcagcgc cctggaccag      840

gtgaatagga caaggctggg cccagatttc cagccattca cacaggagca gaaggaaata      900

atcctggata aaatgttcca gcgcaccgac tactataaaa agaagaccat cccggaggtg      960

tcatactacg atataaggaa gtggctggag ctggatgaaa ccatccagtt caagggatta     1020

aactacgacc cgaacgagga gctgaagaaa atagagaaga agccgttcat aaacctgaag     1080

gccttctacg aaatcaagaa ggtggtggcc aactacgccg agcgaaccaa cgaagcattc     1140

agcaccctgg actacgacgc catcgcctac gccctgaccg tgtataaaac cgacaaggat     1200

ataaggtcat acctgaagaa atcaaacaac ctgagcaagc gctgctacga cgaccaatta     1260

atcgaggagc tgttcaccct gagctatact aagttcggcc acctgagctt caaggcaatc     1320

aaccacgtgc tgccaataat gcaggagggc cgcacctacc aggaggcaat acaccagctg     1380

ggctacgaca ccaccaacct gaagaaggag aaccgcagca tgttcctgcc gctaatcccg     1440

gacgagatca ccaacccgat cgtgaagcgc gccatcaccc aggctaggaa ggtggtgaac     1500

gccatcatcc gccgctacgg cagcccgaac agcgtgcaca tcgagctggc ccgcgagctg     1560

agcaagagcc acgacgagcg caagaagatc atgacagccc acgacgagaa ctacaagaag     1620

aacaagggcg ccatctcaat cctgatcgag aacggcatcc tgaacccaac cggctatgac     1680

atcgtgcgct acaagctgtg gaaggagcag ggcgagaggt gcgcctactc tctgaaggag     1740

atcccaccag atacattctt caacgagctg aagaaggaga ggaatggctc tccaatcctg     1800

gaggtggatc acatcctgcc atacagccag tcattcatcg acagctacca caacaaggtg     1860

ctggtgtaca gcgatgagaa caggaacaag ggcaaccgca tcccgtacac atacttcctg     1920

gagaccaaca aggattggga ggccttcgag aggtacgtga ggagcaacaa gctgttcagc     1980

aagaagaagc gcgagtacct gctgaagaag acctacctgc caagggagtc agagctgatc     2040

aaggagaggc acctgaacga tacaaggtac gctagcacct tcctgaagaa cttcatcgag     2100

cagaacctgc agttcaagga ggtggaggtg aacctgagga agaagcgcgt tcagacagtg     2160

aacggcgtga tcacagccca cctgaggaag aggtggggcc tggagaagaa taggcaggag     2220

acatacctac accacgccat ggatgccatc atcgtggctt gcacagatca ccacatggtg     2280

acaaggatca cagagtacta ccagatcaag gagagcaaca agagcgtgaa gaagccatac     2340

ttcccaatgc catgggaggg cttcagggat gagctgctgt ctcacctggc ctctcagcca     2400

atcgccaaga agatctcaga ggagctgaag gccggctacc agtcttctga ttacatcttc     2460

gtgtctagga tgccaaagag gtctgtgaca ggcgccgccc acgatcagac aatcaggagg     2520

aagggcggca tcgataagaa gggcaagaca atcatcatca agagggtgag gctgaaggat     2580

atcaagttcg atgagaacgg cgatttcaag atggtgggca aggagcagga tctagccaca     2640

tacgaggcca tcaagcagcg ctacctggag cacaggaaga actctaagaa ggccttcgag     2700

acaccactgt acaagccatc taagaagggc accggcaatc tgatcaagag ggtgaagatc     2760

gagggccaga caaaggcctt cgtgagggag gtgaatggcg gcgtggccca gaattctgat     2820

ctggtgaggg tggatctatt cgagaaggac gataagtact acatggtgcc aatctacgtg     2880

ccagatacag tgtgctccga gctgccaaag aaggtggtga agtctggcaa gggctacgag     2940

cagtggctca cactggataa cagcttcaca ttcaagagca gcctgtaccc atacgatctg     3000

gtgaggctgg tgaagggcaa tgaggacagg ttcctgtact tcggcacact agacatcgat     3060

agcgacaggc tgaacttcaa ggacgtgaac aagccaagca agcagaacga gtaccgctac     3120

agcctgaaga ccatcgagaa cctggagaag tacgaggtgg gcgtgctggg cgatctgagg     3180

ctggtgaagc aggagacaag gaggatcttc aatagg                               3216


<210> 177
<211> 4011
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05459.1 Soy optimized"

<400> 177
atgaagaagg actacgtgat cggactagat attggaacta actctgtggg atgggctgtt       60

atgactgagg attaccagct agttaagaag aagatgccca tctacgggaa tacagagaag      120

aagaagatca agaagaactt ctggggagtg agactatttg aagagggtca tactgctgag      180

gataggagat taaagagaac tgctaggaga aggatttcta ggaggaggaa caggcttcgt      240

taccttcaag cattctttga agaggctatg accgctctag atgaaaattt cttcgctagg      300

cttcaggagt cttttcttgt gcctgaggat aaaaagtggc acaggcatcc tatttttgct      360

aagttagagg atgaggtggc ttaccatgaa acctacccta ctatctacca ccttaggaag      420

aagttggctg attcttcaga gcaagccgac ttgagattaa tctaccttgc tcttgcccac      480

attgtaaaat ataggggaca cttccttatc gagggaaaac tctccaccga aaatatttca      540

gtgaaggagc agtttcagca gttcatgatc atctataacc aaaccttcgt gaacggagaa      600

tcaaggcttg tgtctgctcc tcttcctgag tccgtattaa ttgaggagga acttactgag      660

aaagcatcca gaaccaagaa gtctgagaag gttcttcaac agtttcctca agagaaggct      720

aacggacttt tcggacagtt cctcaaatta atggtgggga ataaagccga cttcaagaag      780

gtttttggac ttgaggagga ggccaaaata acttacgctt ctgagtctta tgaggaggat      840

cttgagggaa tactagctaa ggtgggagat gaatacagcg atgttttcct tgctgctaag      900

aacgtttacg acgctgtgga attaagcacc atactagctg actccgataa aaagtctcac      960

gccaaactct cttcaagcat gattgttagg ttcactgagc atcaggagga tcttaagaag     1020

ttcaagaggt tcattaggga gaactgccct gatgagtacg ataacctttt caagaacgag     1080

caaaaggatg ggtacgctgg atacattgct catgctggaa aggtgtcaca attaaagttc     1140

taccagtacg tgaagaaaat aatccaggat atcgctggag ccgagtactt ccttgagaaa     1200

atagctcagg agaacttcct taggaagcag aggactttcg ataacggagt gattcctcac     1260

caaatacacc ttgctgagct acaggcaata attcataggc aagctgcata ctatcctttc     1320

ctcaaggaga atcaagagaa aatagagcag ctcgtgacct tcagaattcc atactacgtg     1380

ggacctcttt ctaagggaga tgcttctact tttgcttggc ttaagagaca gtcagaggaa     1440

ccaattaggc cttggaatct tcaagagact gtggatcttg atcaatctgc tactgctttc     1500

atagagagga tgaccaactt cgatacatac cttccttctg agaaggtgct ccctaagcat     1560

tctctcctct atgaaaagtt catggtgttc aacgagctaa ccaaaatatc ctacaccgac     1620

gataggggaa tcaaggctaa tttctctgga aaggagaagg agaaaatatt cgactacctc     1680

ttcaagacca ggaggaaggt gaagaagaag gacataatac agttctaccg caacgaatac     1740

aacaccgaga ttgtgacctt gtcaggactt gaggaggatc aattcaacgc ttctttctct     1800

acctaccagg atctattaaa gtgcggactt actagggctg agcttgatca tcctgataat     1860

gctgagaagc tggaggacat aatcaagata ctaaccatct tcgaggatag gcaaaggatt     1920

aggacccagc tttctacttt caagggacaa ttctctgctg aggttcttaa gaagttggag     1980

aggaagcatt atactggatg gggaaggctc tctaagaagc tcattaacgg aatctacgat     2040

aaggagtcag ggaagaccat cctagattac ctcattaagg atgatggagt gtctaagcac     2100

tacaacagga acttcatgca gctcattaac gattcccagc tctccttcaa gaacgctatt     2160

caaaaggctc aatcttctga gcatgaagag actctttctg agactgttaa cgaattagct     2220

gggtcccctg ctattaagaa gggaatctac cagtctctca agattgtgga tgagcttgtg     2280

gctattatgg gatatgctcc taagaggatt gttgttgaga tggctaggga gaaccaaact     2340

acttctactg gaaagaggag gtctattcag aggctaaaga ttgttgaaaa ggctatggct     2400

gagattggat ctaaccttct taaggagcag cctactacta acgagcaact tagggatacc     2460

aggctcttcc tttactacat gcagaacgga aaggatatgt acactggaga tgagctttct     2520

cttcataggc tctcacacta cgacatagat cacattatcc ctcagtcctt catgaaggat     2580

gattctctcg ataaccttgt gcttgtggga tctactgaga ataggggaaa gtctgatgat     2640

gttccttcta aggaggtggt taaggatatg aaggcttact gggagaaact atacgctgct     2700

ggacttattt ctcaaaggaa gttccagaga cttactaagg gagagcaagg aggacttact     2760

cttgaggata aggctcattt cattcaaagg cagcttgttg agaccaggca gattactaag     2820

aacgtggctg gaattctaga tcaaaggtac aacgctaact ctaaggagaa gaaggttcag     2880

atcattaccc tcaaggcttc tcttacctcc cagttcaggt ctattttcgg actttacaag     2940

gttagggagg tgaacgatta ccatcatgga caagatgctt accttaactg cgtggttgct     3000

actactctac ttaaggttta tcctaacctt gctcctgagt tcgtttacgg agagtatcct     3060

aagttccagg ctttcaagga gaataaggct accgctaaga ccattatcta caccaacctt     3120

atgaggttct ttactgagga tgagcctagg tttatgaagg atggagagat tctctggtca     3180

aactcctacc tcaagaacat caagaaggag cttaactacc accagatgaa cattgtgaag     3240

aaggtggagg ttcaaaaggg aggattctcc aaggagtcta ttaagcctaa gggaccttct     3300

aacaagctca ttcctgtgaa gaacggactt gatcctcaaa agtacggagg attcgattca     3360

cctgttgttg cttacactgt tcttttcact cacgaaaagg ggaagaagcc tctcattaag     3420

caggagattc tcggaattac cattatggag aagactaggt tcgagcagaa ccctattctt     3480

tttctagagg agaagggatt tcttaggcct agggttctta tgaagctccc taagtacact     3540

ctttatgagt ttcctgaggg aagaaggaga cttcttgctt ctgctaagga ggctcaaaag     3600

ggaaaccaaa tggttcttcc tgagcacctt cttactcttc tttaccatgc taagcaatgc     3660

ctacttccta accaatctga gtctcttgct tacgtagaac aacatcaacc tgagttccaa     3720

gagattcttg agagggttgt ggatttcgct gaggttcata cccttgctaa gtctaaggtt     3780

cagcagattg ttaagttgtt cgaggctaac cagactgctg atgttaagga gatcgctgct     3840

tcattcattc agcttatgca attcaatgct atgggtgctc cttctacctt caagttcttc     3900

cagaaggata tagagagggc taggtacacc tccatcaagg agattttcga tgctaccatt     3960

atctaccagt ctactactgg actttatgag actaggagga aggtggttga t              4011


<210> 178
<211> 4011
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05459.1 Corn optimized"

<400> 178
atgaaaaagg actacgtgat cggcctggac atcggcacta attcagtggg ctgggccgtg       60

atgacagagg actaccagct ggtgaagaag aagatgccta tctacggcaa cactgagaag      120

aagaagatca agaagaactt ctggggcgtg cgcctattcg aggagggcca cacagccgag      180

gaccgcagat taaagaggac agccaggagg aggatctcta ggaggaggaa taggctgcgc      240

tacctgcaag cattcttcga ggaggccatg acagccctgg atgaaaattt cttcgccagg      300

ctgcaggagt ctttcctagt gccggaggat aaaaagtggc acaggcaccc tatcttcgcc      360

aagctggagg atgaggtggc ctaccatgaa acatacccaa caatctacca cctgaggaag      420

aagctggccg attcttctga gcaggccgac ctgagattaa tctacctggc cctggcccac      480

atcgtcaaat acaggggcca cttcctgatc gagggcaaac tgagcacaga aaatatcagc      540

gtgaaggagc agttccagca gttcatgatc atctataacc aaaccttcgt gaacggcgaa      600

tcaaggctgg tgagcgcccc actgccggag agcgtattaa tcgaggagga actgaccgag      660

aaagcatccc gaaccaagaa gagcgagaag gtgctgcagc agttcccgca agagaaggct      720

aatggcctgt tcggtcagtt cctgaaactg atggtgggca ataaagccga cttcaagaag      780

gtgttcggcc tagaggagga ggccaaaata acctacgcca gcgagagcta cgaggaggac      840

ctggagggca tactagccaa ggtgggcgat gaatacagcg atgtgttcct ggccgccaag      900

aatgtgtacg atgccgtgga gctgtctaca atactagccg acagcgataa aaagagccac      960

gccaagctct cttcaagcat gatcgtgagg ttcacagagc atcaggagga cctgaagaag     1020

ttcaagcgct tcatcaggga gaactgcccg gacgagtacg acaacctgtt caagaacgag     1080

cagaaggatg gctacgccgg atacatcgcc cacgccggta aggtgtccca attaaagttc     1140

taccagtacg tgaagaaaat aatccaggac atcgccggcg ccgagtactt cctggagaaa     1200

atagcccagg agaacttcct gcgcaagcag aggacattcg acaacggcgt catcccgcac     1260

cagatacatc tggccgagct gcaggccatc atacataggc aggccgcata ctacccattc     1320

ctaaaggaga accaagagaa aatagagcag ctggtgacct tccgcatccc atactacgtg     1380

ggcccactgt ctaagggcga tgcctctaca ttcgcctggc tgaagaggca gtctgaggaa     1440

ccaatcaggc catggaatct gcaagagaca gtggatctgg atcagtctgc cacagccttc     1500

atcgagagga tgaccaactt cgatacatac ctaccaagcg agaaggtgct gccaaagcat     1560

agcctgctgt atgaaaagtt catggtgttc aacgagctaa ccaagatcag ctacaccgac     1620

gaccgcggaa tcaaggccaa cttcagcggc aaggagaagg agaaaatatt cgactacctg     1680

ttcaagaccc gccgcaaggt gaagaagaag gacataatac agttctaccg caacgaatac     1740

aacaccgaga tcgtgaccct gagcggcctt gaggaggacc agttcaacgc cagcttctca     1800

acctaccagg acctattaaa gtgcggcctg acccgcgccg agctggacca cccggataac     1860

gccgagaagc tggaggacat aatcaagata ctaaccatct tcgaggaccg ccagcgcatc     1920

cgcacccaat taagcacctt caagggccag ttcagcgccg aggtattaaa gaagctggag     1980

cgcaagcatt acacaggctg gggcaggctg agcaagaagc taatcaacgg catctacgac     2040

aaggagagcg gcaagaccat ccttgactac ctgatcaagg acgatggcgt gagcaagcac     2100

tacaaccgca acttcatgca gctgatcaac gacagccagc tgagcttcaa gaacgccatc     2160

cagaaggccc agtcttctga gcacgaggag acactgtctg agacagtgaa tgagctggcc     2220

ggctcaccag ccatcaagaa gggcatctac cagtctctga agatcgtgga tgagctggtg     2280

gccatcatgg gctacgcccc aaagaggatc gtggtggaga tggccaggga gaatcagaca     2340

acatcaacag gcaagaggag gtctatccag aggctgaaga tcgtggagaa ggccatggcc     2400

gagatcggct ctaatctgct gaaggagcag ccaacaacaa atgagcagct gagggataca     2460

aggctgttcc tgtactacat gcagaatggc aaggatatgt acacaggcga tgagctgtct     2520

ctgcataggc tgagccacta cgacatcgat cacatcatcc cgcagtcatt catgaaggac     2580

gactctctgg ataatctggt gctggtgggc tctacagaga acaggggcaa gagcgatgat     2640

gtgccatcta aggaggtggt gaaggatatg aaggcctact gggagaagct gtacgccgcc     2700

ggcctgatct ctcagaggaa gttccagagg ctgacaaagg gcgagcaggg cggcctgaca     2760

ctggaggata aggcccactt catccagagg cagctagtgg agacaaggca gatcacaaag     2820

aatgtggccg gcatcctgga tcagaggtac aatgccaatt ctaaggagaa gaaggttcag     2880

atcatcacac tgaaggcctc tctgacatct cagttcaggt ctatcttcgg cctgtacaag     2940

gtgcgcgagg tgaatgatta ccaccacggc caggatgcct acctgaattg cgtggtggcc     3000

acaacactac tgaaggtgta cccaaatctg gccccagagt tcgtgtacgg cgagtaccca     3060

aagttccagg ccttcaagga gaataaggcc acagccaaga caatcatcta cacaaacctg     3120

atgaggttct tcacagagga cgagccaagg ttcatgaagg atggcgagat cctgtggagc     3180

aacagctacc tgaagaacat caagaaggag ctgaactacc accagatgaa catcgtgaag     3240

aaggtggagg tccagaaggg cggcttctca aaggagagca tcaagccgaa gggcccgagc     3300

aacaagctga tcccagtgaa gaatggcctg gacccacaga agtacggcgg ctttgattct     3360

ccagtggtgg cctacacagt gctgttcaca cacgagaagg gcaagaagcc actgatcaag     3420

caggagatcc tgggcatcac aatcatggag aagacaaggt tcgagcagaa cccaatcctg     3480

ttcctggagg agaagggctt cctgaggcca agggtgctga tgaagctacc aaagtacaca     3540

ctgtacgagt tcccagaggg caggaggagg ctgctggcct ctgccaagga ggcccagaag     3600

ggcaatcaga tggtgctgcc tgagcacctg ctgacactgc tgtaccacgc caagcagtgc     3660

ctgctgccaa atcagtctga gtctctggcc tacgtggagc agcaccagcc agagttccag     3720

gagatcctgg agagggtggt ggatttcgcc gaggtgcaca cactggctaa gtctaaggtt     3780

cagcagatcg tgaagctgtt cgaggccaat cagacagccg atgtgaagga gatcgccgcc     3840

tcattcatcc agctgatgca gttcaatgcc atgggcgccc catctacatt caagttcttc     3900

cagaaggata tcgagagggc caggtacaca tctatcaagg agatcttcga tgccacaatc     3960

atctaccagt ctacaacagg cctgtacgag acaaggagga aggtggtgga t              4011


<210> 179
<211> 4308
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG04583.1 Soy optimized"

<400> 179
atggccaaaa atattctagg actcgatctc ggaaccaact ctattggatg ggctcttgtt       60

cagcaggact ttgaaaataa ggaggggaac atactaggaa tggggtccag aataattcct      120

atgtctcagg atatactagg agagttcggg aagggtaact ctatttctca aactgctgag      180

agaactggat ataggggagt tagaaggtta agggagagac atcttcttag aagggagagg      240

cttcataggg tgcttcatct tcttggattc ctacctaagc attacgacga gaaaatagac      300

ttcactcaga ggttcgggaa gttcatcaat caagctgaac caaagttggc tttcgattca      360

gagttcctct tcaaggactc cttccatgaa atgctagctg acttcaagca gaatcaacct      420

gagttcctca aggataaaaa cggagaggat tgccttgttc cttacgactg gactatatac      480

tacctaagga agaaagcatt gacccagaag atcgaaaaat atgagctggc ctggctcatc      540

ctcaacttca atcaaaagag gggatactat caattaaggg gagaggagga gaaggagaac      600

cctaataaac tcgtggggtt ccactctctc aaaatagtgg atgttattcc tgacgctgaa      660

accaataaaa agggagagac ctggtactca cttcatcttg agaacggatg ggtttatagg      720

aggtcctcca aaatatctct cgctgattgg aaggacaaag tgagggattt cattgtgacc      780

accgatctta atgatgatgg atcagagaag ctcgataagg atggaattgt gaagaggtct      840

tttagggctc cttctgctga tgactggacc ctattaaaga agaagaccga gaaggatatc      900

gacaactcta ataaaaccgt ggggacctac atctacgaca acctcctatt aaaccccaag      960

cagaaaatca agggaaagat ggttaggacc attgagagga agttctacaa gcaagagctg     1020

gagcagatat taaagactca gaaggagttc cattctgagc ttcagtctga gaacttgctt     1080

caagattgcg ttagggagct gtacaggaat aatgagcaac atcaacagat gcttgaggct     1140

aaggatttcg tgcacctctt cctcaacgat ataattttct accagaggcc tcttaggtcc     1200

cagaaatcaa gcatttctaa ttgcaccctt gagttccgca agtccaagaa tgaaaacgga     1260

gaggaggtaa tacacagatt aaaggtgatc gccaaatcaa acccatacta ccaggagttc     1320

aggcttcttc aatgggttca gaacctcgct atctatacta aggacgacga taagaacgta     1380

accaacgagt tcctcaaatc aactcaggat tgggaggatc ttcttaggtg gcttcactct     1440

aagaaggaaa tcaagcagga tgctctaatc aagttcctca ttgagaagaa gggactcaag     1500

gggaaagcat tgactattga ggtggcaaaa tataggtgga actacgttca ggataaggat     1560

taccctggaa atgaaacccg ctacctcatt caatcaaggc ttgataaggt tgagtacgct     1620

cctaaggatt tcctcaccta tgaaaatgaa atggccctct ggcatatcat ctactcaatc     1680

aacgacaaga tcgagtatga aaaggcatta aagtccttcg ccaataaaaa ggggctcgat     1740

gaggtgacct tcgtggaagc attcaagaag ttccctcctt tcaagtccga ttacggatct     1800

ttctctgaga aggcaatcaa gaagctcctt ccattaatga ggttcggaac tcaatggaac     1860

tgggataaca tcgaccaaaa tagcaaggag aggattggaa aaatactaac cggggagtac     1920

gatgaaaata ttaaagggag ggttagggag aaggctaggc accttaactc tgagaccgat     1980

tttcaagcat tacctctttg gcttgctcag tacgttgttt atggaaggca ctctgaagct     2040

gatattgctg gaaagtggaa ctctgtggat gatctcaagc agttccttga tgatttcaag     2100

cagcattcct tgaggaaccc tattgtggag caggttatta ctgagactct tagggctgtt     2160

aaggatattt ggaacttcta cggaaagggg gctaaggatt tcttctcaga aatacacatt     2220

gagcttggga gggagatgaa aaataccgct gatgaaagga agaggattac caccatggtg     2280

accgacaatg aaaataccaa cctcagaatc aaagcattgc ttgctgagat ggctcttgat     2340

cagaacgttg ataacgttag gccttactct cctatgcagc aggagattct taagatctat     2400

gaggagggag ttctaaacgc tgaggagaac atcgatgatg atatcctcaa gatttctaag     2460

actgctcagc cttctgctac cgatcttaag aggtataagt tgtggcttga gcaaaagtac     2520

aggtctcctt acactggaca gatgattcct cttaacaagt tgttcacccc tgagtacgag     2580

atcgagcaca ttattcctca gtctaggtac ttcgacgatt caatgtccaa caaggttatt     2640

tgcgaggctg ctgtgaacaa gttgaaggat aaccagattg gactcgtgtt cattaagaac     2700

catcatggag aggtggttga tttcggaatg ggaaagcagg tgaagattct tgaggtttct     2760

gattacgagg atttcgtgaa gcagaactat aacaagaaca ggggaaagag gaacaagctc     2820

ctcttagagg atatccctga gaagatgatt gagaggcagc ttaacgatac caggtacatc     2880

tctaagtaca ttacccaggt gctttccaac attgttaggg atgataagga gggatctaag     2940

gatgatggag tgaactccaa gaacattgtt cctggaaacg gaaagattac caccaggctt     3000

aaacaggatt ggggacttaa cgatgtgtgg aacgatcttg ttcttcctag gttcgagagg     3060

atgaacactc ttaccaactc taacgatttc acctctaaga acactcacgg aaagactatt     3120

cctactgtgc ctattgagct ttcaaaggga ttctccaaga agaggattga tcacaggcat     3180

catgctatgg atgctcttgt tattgcttgc gctactaggg atcatgtgaa ccttctcaac     3240

aacgagtctt ctaagtctga taccaagagg tacgatctta acaggaagtt gaggaagtac     3300

gagaaggttg cttacaacga tcctaagact ggagagagaa ttgagaagga ggtgcctaag     3360

gattttatta agccttggga gacctttact gaggatacta ggacccttct tgagaacatc     3420

gtgatttctt tcaagcagaa cctcagggtg attaacaagg ctaccaacta ctacgagaag     3480

attgagaacg gaaagaaggt gaaggttgag cagaagggaa ttaattgggc tgttaggaag     3540

gctctacata aggagactgt ttctggacag gtgcaccttg ataggattaa agtggctaag     3600

ggaaagattc ttaccgctac taggaagact cttgatgctt ctttcaacga gaagaccatt     3660

gagtctatta ccgataccgg gattcagaag attctcctca actacctcaa gtccaaggat     3720

aacaatcctg aggttgcttt ctctcctgaa ggaattgagg agcttaacaa gaacatcagg     3780

ctctataacg atggaaaggc tcaccagcct attcttaagg ttagggtttt cgagcaggga     3840

tctaagttta ctcttggaga gactggaaac aagactacta agtttgttga ggctgctaag     3900

ggaaccaacc ttttcttcgg aatctacgag gataagtctg gaaagaggtc ttacgagacc     3960

atccctttga acattgttat tgagaggcaa aagcaaggac tacaagctgt tcctgagact     4020

aacgagaagg gaaagcagct tcttttcacc ctttctccta acgatcttgt ttatgttcct     4080

gaggagggag ttttcgatga gaacaacatc aaggtggata ggatctacaa ggtggtgtct     4140

ttctctactt accaatgctt cttcgtgagg aacgatgtgt ctacttctgt ggttaacaag     4200

gttgagtact ctgctctcaa caagatggag aagtccatcg acaacatcat gattaaggag     4260

aactgcgtga agttgaacgt tgataggctc ggaaagattt ccaaggct                  4308


<210> 180
<211> 4308
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG04583.1 Corn optimized"

<400> 180
atggccaaga acatactagg cctggacctc ggaaccaatt ctatcggctg ggccctggtt       60

cagcaggact ttgagaacaa ggagggcaac atactaggca tgggcagccg aataatccct      120

atgtctcagg acatactggg cgagttcggt aagggcaaca gcatctcaca gacagccgag      180

aggacaggct accgcggcgt gaggaggctc agggagaggc acctgcttag gagggagagg      240

ctacacaggg tgctgcatct gctgggcttc ctgccaaagc attacgatga aaagatagat      300

ttcacacaga ggttcggcaa gttcatcaat caagccgaac caaagctagc cttcgattct      360

gagttcctgt tcaaggacag cttccatgaa atgctggccg acttcaagca gaatcaaccg      420

gagttcctga aggataaaaa cggcgaggac tgcctagtgc cgtacgactg gaccatatac      480

tacctgcgca agaaggccct cacccagaag atcgaaaaat acgagctggc ctggctgatc      540

cttaacttca accaaaagcg cggatactac cagctacgcg gcgaggagga gaaggagaac      600

ccgaataaac tggtgggctt ccacagcctg aaaatagtgg acgtgatccc ggacgccgag      660

actaataaaa agggcgagac ctggtactca cttcacctgg agaacggctg ggtgtaccgc      720

aggagcagca aaatatctct ggccgactgg aaggataaag tgagggactt catcgtgacc      780

acagacctga acgacgatgg ctcagagaag ctggacaagg atggcatcgt gaagaggtca      840

ttcagggccc catctgccga tgactggacc ctattaaaga agaagaccga gaaggacatc      900

gacaacagca ataaaaccgt gggcacctac atctacgaca acctgctatt aaacccgaag      960

cagaaaatca agggcaagat ggtgcgcacc atcgagcgca agttctacaa gcaggagctg     1020

gagcagatac taaagaccca gaaggagttc cacagcgagc tgcagagcga gaacctgctg     1080

caggactgcg tgcgcgagct gtaccgcaat aatgagcagc accagcagat gctggaggcc     1140

aaggacttcg tgcacctgtt cctgaacgat ataatcttct accagaggcc gctcaggagc     1200

cagaagtcaa gcatcagcaa ttgcaccctg gagttccgca agagcaagaa tgaaaacggc     1260

gaggaggtga tacatcgatt aaaggtgatc gccaagagca acccatacta ccaggagttc     1320

cgcctgctgc agtgggtcca gaacctggcc atctatacta aggacgacga caagaacgta     1380

accaacgagt tcctgaaatc aacccaggac tgggaggacc tgctgcgctg gctccacagc     1440

aagaaggaaa tcaagcagga cgccctaatc aagttcctga tcgagaagaa gggattaaag     1500

ggcaaagcat tgaccatcga ggtggcaaaa tacaggtgga actacgtcca ggacaaggac     1560

tacccgggca atgaaacccg ctacctaata cagagccgcc tggacaaggt ggagtacgcc     1620

ccgaaggact tcctgaccta cgagaatgaa atggccctgt ggcatatcat ctactcaatc     1680

aacgacaaga tcgagtatga aaaggcatta aagagcttcg ccaataaaaa gggcctggac     1740

gaggtgacct tcgtggaagc attcaagaag ttcccgccgt tcaagagcga ctacggcagc     1800

ttcagcgaga aggcaatcaa gaagctgctg ccattaatgc gcttcggcac ccagtggaac     1860

tgggacaaca tcgaccaaaa tagcaaggag cgcatcggca aaatactaac cggcgagtac     1920

gacgagaaca taaagggccg cgtgcgcgag aaggcccgcc acctgaacag cgagaccgac     1980

ttccaagcat tgccgctgtg gctggcccag tacgtggtct acggcaggca cagcgaggcc     2040

gatatcgccg gcaagtggaa cagcgtggat gatctcaagc agttcctgga cgatttcaag     2100

cagcacagcc tgaggaatcc aatcgtggag caggtgatca cagagacact aagggccgtg     2160

aaggacatct ggaatttcta cggcaagggc gccaaggact tcttcagcga gatacatatc     2220

gagctgggcc gcgagatgaa aaacaccgcc gatgaaagga agaggatcac aaccatggtg     2280

accgacaatg aaaacaccaa cctgcgaatc aaggccctgc tggccgagat ggccctggat     2340

cagaacgtgg ataacgtgag gccatactct ccaatgcagc aggagatcct gaaaatatac     2400

gaggagggcg tattaaacgc cgaggaaaat atcgacgacg acatcctgaa aataagcaag     2460

accgcccaac caagcgccac cgacctgaag cgatataagc tgtggctgga gcaaaaatac     2520

aggagcccgt acaccggcca gatgatcccg ctgaataaac tgttcacccc ggagtatgaa     2580

atcgagcata taatccctca gagccgctac ttcgacgaca gcatgagcaa caaggtgatc     2640

tgcgaggccg ccgtgaacaa gctaaaggac aaccagatcg gcctggtgtt catcaagaac     2700

caccacggcg aggtggtgga cttcggcatg ggcaagcagg tgaagatcct ggaggtgagc     2760

gactacgagg acttcgtgaa gcagaactac aacaagaacc gcggcaagag gaacaagctg     2820

ctgctggagg acatccctga gaagatgatc gagaggcagc tgaacgacac ccgctacatc     2880

agcaagtaca tcacacaggt gctgagcaac atcgtgaggg acgataagga gggctcaaag     2940

gatgatggcg tgaacagcaa gaacatcgtg ccaggcaacg gcaagatcac aacaaggctg     3000

aagcaggatt ggggcctgaa cgatgtgtgg aatgatctgg tgctgccaag gttcgagagg     3060

atgaacaccc tgaccaacag caacgacttc acctctaaga acacccacgg caagacaatc     3120

ccaacagtgc cgatcgagct gagcaagggc ttcagcaaga agaggatcga tcacaggcac     3180

cacgccatgg atgccctggt gatcgcctgc gccacaaggg atcacgtgaa tctactgaat     3240

aacgagtcta gcaagagcga tacaaagagg tacgatctga acaggaagct gcgcaagtac     3300

gagaaggtgg cctacaacga tccaaagaca ggcgagagga tcgagaagga ggtgccgaag     3360

gatttcatca agccatggga gacattcaca gaggacacaa ggaccctgct ggagaacatc     3420

gtgatcagct tcaagcagaa cctgcgcgtg atcaacaagg ccaccaacta ctacgagaag     3480

atcgagaacg gcaagaaggt gaaggtggag cagaagggca tcaattgggc cgtgaggaag     3540

gccctacata aggagacagt gtctggccag gtgcacctgg ataggatcaa ggtggccaag     3600

ggcaagatcc tgacagccac aaggaagaca ctggatgcct ctttcaacga gaagacaatc     3660

gagagcatca cagacaccgg catccagaag atcctgctga actacctgaa gagcaaggac     3720

aacaacccag aggtggcctt ctctccagag ggcatcgagg agctgaacaa gaacatcagg     3780

ctgtacaatg atggcaaggc ccaccagcca atcctgaagg tgcgcgtgtt cgagcagggc     3840

tcaaagttca cactgggcga gacaggcaat aagacaacaa agttcgtgga ggccgccaag     3900

ggcacaaatc tgttcttcgg catctacgag gataagtctg gcaagaggtc ttacgagaca     3960

atcccgctga atatcgtgat cgagaggcag aagcagggac tgcaggccgt gccagagaca     4020

aatgagaagg gcaagcagct gctgttcaca ctgtctccaa atgatctggt gtacgtgcca     4080

gaggagggcg tgttcgatga gaacaatatc aaggtggaca ggatctacaa ggtggtgagc     4140

ttctcaacct accagtgctt cttcgtgagg aacgacgtga gcacaagcgt ggtgaacaag     4200

gtggagtaca gcgccctgaa caagatggag aagagcatcg acaacatcat gatcaaggag     4260

aactgcgtga agctgaacgt ggaccgcctg ggcaagatct ctaaggcc                  4308


<210> 181
<211> 4368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG01688.1 Soy optimized"

<400> 181
atgatgatca agaacatact aggactcgat ctcggaacca actctatcgg atgggctcta       60

atcaagcagg atttcgagaa caagcatgga gaaatactag ggatgggctc cagaataatt      120

cctatgtccc aggatatact aggagatttc ggaaagggta actctatttc tcagaccgct      180

gatagaacca agtataggtc tgttagaagg cttagggaga gatttcttct taggagagag      240

aggcttcata gggtgctcca cctattaaac ttccttcctc aacactacgc ttctcagatc      300

gatttcgaga agaagttcgg aaagtttaag tctgagaccg aaccaaagtt agcttgggaa      360

aattggggag gaaagttctc tttcctcttc caaaatagct tcaatgaaat gctggaggat      420

ttcaaggctg ctggacaggg gctcaaaata ccttacgact ggaccatata ctatctcagg      480

aagaaagcat tgtcccagaa aatagagaag gaggagctag cttggatact cctcaacttc      540

aatcaaaaga ggggatacta tcaattaaga ggtgaggagg aggaggagaa ccctaataaa      600

ctcgtggagt tctactccct caaaatagtg gatgttgttg ctgatgagcc tcagaaggga      660

aagtccgata tctggtactc attaattctt gagaacggat gggtttatcg cagggcttcc      720

aaaatacctc tcttcgactg gaaggataaa accagggatt tcattgtgac caccgatctt      780

aacgatgata ggtctgtgaa gactgataag gagggaaatg aaaagaggtc ttttagggct      840

ccttcagaga acgattggac tcttgtgaag aagaagactg agcaggagat tgatcagtct      900

cataaaaccg tgggaaccta catctatgaa accctcctat taaaccccaa gcagaaaatc      960

aagggaaagt tggtgaggac cattgagagg aagttctaca aggacgagct taagcagata     1020

ctagagaagc aaaaggagtt ccaccaggaa ttaaagaacg acgacctata taacgactgc     1080

attagggagc tgtacaggaa taatgaggct caccaattaa ccctctccaa gaaggatttc     1140

gtgcacctat taatggacga tctcattttc taccagaggc ctcttaggtc ccagaaatca     1200

agcatttcta attgcaccct ggagttcaga aaatacaagg atgaaaacgg gattgagcac     1260

acccagtacc tcaaggctat cccaaaatca aacccatact accaagagtt taggctttgg     1320

cagtggatgt acaacttgaa catctacaga aaggatgatg aggctaacgt aaccaaggag     1380

ttcctcaaca ccaataaaga cttcgagtct ctcttcgagt tcctcaataa tcgcaaggag     1440

attgagcaga agcccctaat caagttcctt cttgagcaga aggacataaa caagaagcta     1500

ttaaacgccg aggctgagaa atacaggtgg aactacgtgg aggataaaaa gtacccctgc     1560

aatgaaacca agaccatgat ttcctctagg cttgacaagg tggaaaatat ctccgatgat     1620

ttcctcacca gggacatcga gcagaaaata tggcatataa tctactccgt gaacgacaag     1680

atcgagtatg aaaaggcatt aaagtccttc gctaccagga acgacctcga tgaaaatagc     1740

ttcatcgaag cattcaagaa gttctcccct ttcaagtccg agtacggatc tttctctgag     1800

aaggcaatca agaagctcct tccattaatg aggctcggaa aatactggta cgaggatgaa     1860

atcgtgaagc attccgacat ctacttcaaa aatattgaga acctcctcgg ggatttctcc     1920

aaccgcgaca agaaaatatc tgaggaagac aaggagaagt ggaacaagtc aatcaacctt     1980

aagctccagg aggaattaaa ggatttccag accgctgaga ttgatttgtt ccagggactt     2040

aggcttcaca ttgctcagta ccttgtttat ggaaggcact ccgaagcatc tatgattgga     2100

aagtggaatt ctgctgagga tcttgaggag ttccttaagg atttcaagca gcattccctt     2160

aggaacccta ttgtggagca ggttattact gagactctta gggtggttaa ggatatttgg     2220

ctaaagtacg gaaacggggc taaggatttc ttcaacgaga ttcatattga gcttggaagg     2280

gaaatgaagt tgcctgctga tgataggaag aagctcacca accaaatttc tgagaacgag     2340

aacaccaact tcaggattaa ggctctcctt gctgagatga tgaacgattc ttctgttgag     2400

aacgttaggc ctttctctcc tatgcagcag gagattctaa agatctacga ggatgatgtg     2460

ctcaagtccg atatcgagat cgaggatgat atcctcaaga tttctaagac tgctcaacct     2520

tctccttctg atcttaagag gtacaagttg tggcttgagc agaagtacaa gtctccttac     2580

accggacaga ttattcctct taacaagttg ttcacccctg agtacgagat cgagcacatt     2640

attcctcagt caaggtactt cgatgattcc ttctccaata aggtgatttg cgagtctgct     2700

gtgaacaagc tcaaggataa ctacatcggg cttgagttca ttaagcagtt cggaggaact     2760

attattgagc ttggattcgg gaagtctatt aaggtgttcg agactaagga gtacgaggat     2820

ttcgtgaaga agcattacgc taacaaccag ggaaagagga acaagctcct tatggaagat     2880

atccctgaga agatgattga gaggcagatg aacgatacca ggtacatctc aaagtacatt     2940

tctggggtgc tttctaacat tgttagggtg gaagatggat ctgatgaggg agtgaactct     3000

aagaacattg ttcctggaaa cggaaagatt accacccaac ttaagcagga ttggggactt     3060

aacgatgtgt ggaacgatct cattcttcct aggttcgaga ggatgaatca gcttactaac     3120

tctaaggttt tcactgcttg gaacgagaac taccagaagt tccttcctac tgtgcctatt     3180

gagtactcca agggattctc aaagaagagg attgatcaca ggcatcatgc tcttgatgct     3240

cttgttattg cttgcgctac taaggatcac gtgaaccttc ttaacaacca gtctgctaag     3300

tctgatacca agaggtacga tctcaagaag aagtccatga agttcgagaa ggtggtttac     3360

aacgatgcta agactggaga aaagattgag agggaggttc ctaagcaatt tcttaagcct     3420

tgggagaact tcactcttga tgtgaagcac aaccttgaga ccatcattgt gtcattcaag     3480

cagaacctca gggtgattaa caaggctacc aactactacg agaagtacgt tgagaaggat     3540

ggaactaaga ataaggagag ggttgagcaa actggaacta actgggctat taggaagcct     3600

atgcacaagg atactgtgtc tggaaaagtt gatcttcctt gggttaaggt gcctaaggga     3660

aagattctta ctgctaccag gaagtctctc gattcttctt tcgatctcaa gtccattgga     3720

tctattaccg ataccgggat tcagaagatc ctaaagaact acctcgcttt caaggatgga     3780

aatcctgagc ttgctttctc tcctgaggga attgatgacc tcaacaagaa catcgagaag     3840

tataacgatg gaaagcctca ccagcctatt aacaaggtta gggttttcga gcttggatct     3900

aagttccaag ttggacagtc tggaaacaag aaggataagt atgttgaggc tgctaaggga     3960

accaaccttt tcttcgctgt ttatgaggat gagaagggaa agaggaacta cgagactatt     4020

cctctaaacg aggttattga gaggcaaaag cagggacttt ctgtggttga tcttaagggg     4080

accaacgatt tctatctttg ccctaacgat ttcgtgtaca ttccttctgg agatgagctg     4140

gagaacatca acaacgtgga cttcaaggat atcaagaagg agattaacga gaggatctac     4200

aaggtggtgt ctttcactgg aaacaggctt tcttgcattc cttacatggt ggctaccact     4260

attgtgaaca agttggagtt cacccagcta aacaagattg agttcaccaa ggagaaggag     4320

atctgcatta agttgaacgt ggataggctc ggaaacattt ctaaggct                  4368


<210> 182
<211> 4368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG01688.1 Corn optimized"

<400> 182
atgatgatca agaacatcct aggcctggac ctcggaacca attctatcgg ctgggccctg       60

atcaagcagg acttcgagaa caagcatggc gagatactag gcatgggcag ccgaataatc      120

ccgatgagcc aggacatact aggcgatttc ggcaagggca atagcatctc tcagaccgcc      180

gacagaacca agtacaggtc tgttaggagg ctgagggaga ggttccttct taggagggag      240

aggctgcata gggtgctcca cctattaaac ttcctgccac agcactacgc cagccagatc      300

gacttcgaga agaagttcgg caagttcaag agcgagacag aaccaaagct ggcttgggaa      360

aactggggcg gcaagttcag cttcctgttc caaaatagct tcaatgaaat gctggaggac      420

ttcaaggccg ccggccaggg attaaagatc ccctacgact ggaccatata ctacctgcgc      480

aagaaagcat tgagccagaa aatagagaag gaggagctgg cctggatact gctgaacttc      540

aaccaaaagc gcggatacta ccagctgcgc ggtgaggagg aggaggagaa cccgaataaa      600

ctggtggagt tctactcact gaaaatagtg gacgtggtgg ccgacgagcc gcagaagggc      660

aagagcgaca tctggtacag cctgatacta gagaacggct gggtgtaccg ccgcgctagc      720

aaaataccgc tgttcgactg gaaggataaa acccgcgact tcatcgtgac caccgacctg      780

aacgacgaca ggagcgtgaa gacagataag gagggcaatg aaaagaggag cttcagggcc      840

ccaagcgaga acgattggac cctggtgaag aagaagacag agcaggagat cgatcagagc      900

cataaaaccg tgggcacata catctatgaa accctgctat taaacccgaa gcagaaaatc      960

aagggcaagc tggtgcgcac catcgagcgc aagttctaca aggacgagct gaagcagata     1020

ctagagaagc agaaggagtt ccaccaggaa ttaaagaacg acgacctata taacgactgc     1080

atccgcgagc tgtaccgcaa taatgaggcc caccaattaa ccctgagcaa gaaggacttc     1140

gtgcacctat taatggacga cctgatcttc taccagcgcc cgctgcgcag ccagaagtca     1200

agcatcagca attgcaccct ggagttccgc aaatacaagg atgaaaacgg catcgagcac     1260

acccagtacc tgaaggccat cccgaagagc aacccatact accaggagtt ccgcctgtgg     1320

cagtggatgt acaacctgaa catctaccgc aaggacgacg aggccaacgt aaccaaggag     1380

ttcctgaata caaataaaga cttcgagagc ctgttcgagt tcctgaataa tcgcaaggag     1440

atcgagcaga agccgctaat caagttcctg ctggagcaga aggacataaa caagaagcta     1500

ttaaacgccg aggccgagaa atacaggtgg aactacgtgg aggataaaaa gtacccgtgc     1560

aacgaaacca agaccatgat cagcagccgc ctggacaagg tggaaaatat cagcgacgac     1620

ttcctgaccc gcgacatcga gcagaaaata tggcatataa tctacagcgt gaacgacaag     1680

atcgagtatg aaaaggcatt aaagagcttc gccacccgca acgacctgga tgaaaacagc     1740

ttcatcgaag cattcaagaa gttcagcccg ttcaagagcg agtacggcag cttcagcgag     1800

aaggcaatca agaagctgct gccattaatg cgcctgggaa aatactggta cgaggacgag     1860

atcgtgaagc atagcgacat ctacttcaaa aatatcgaga acctgctggg cgacttcagc     1920

aaccgcgaca agaaaataag cgaggaggac aaggagaagt ggaacaaaag catcaacctg     1980

aagctgcagg aggaattaaa ggacttccag accgccgaga tcgacctgtt ccagggcctg     2040

cgcctccaca tcgcccagta cctggtgtac ggccgccaca gcgaggcaag catgatcggc     2100

aagtggaaca gcgccgagga cctggaggag ttcctgaagg acttcaagca gcatagcctg     2160

cgcaacccga tcgtggagca ggtgatcacc gagaccctgc gcgtggtgaa ggacatctgg     2220

ctaaaatacg gcaacggcgc caaggacttc ttcaatgaaa ttcacatcga gctgggccgc     2280

gagatgaaac tgccggccga cgaccgcaag aagctgacca accaaatcag cgagaatgaa     2340

aacaccaact tccgaatcaa ggccctgctg gccgagatga tgaacgacag cagcgtggag     2400

aacgtgcgcc cgttcagccc gatgcagcag gagatcctga aaatatacga ggacgacgtg     2460

ctgaagagcg acatcgagat cgaggacgac atcctgaaga tcagcaagac cgcccagccg     2520

agcccgagcg acctgaagcg ctacaagctg tggctggagc agaagtacaa gagcccgtac     2580

accggccaga tcatcccgct aaacaagctg ttcaccccgg agtacgagat cgagcacatc     2640

atcccgcaga gccgctactt cgacgacagc ttcagcaaca aggtgatctg cgagagcgcc     2700

gtgaacaagc tgaaggataa ctacatcggc ctggagttca tcaagcagtt cggcggcacc     2760

atcatcgagc tgggcttcgg caagagcatc aaggtgttcg agaccaagga gtacgaggac     2820

ttcgtgaaga agcactacgc caacaaccag ggcaagcgca acaagctgct gatggaggac     2880

atcccggaga agatgatcga gcgccagatg aacgacaccc gctacatcag caagtacatc     2940

agcggcgtgc tgagcaacat cgtgcgcgtg gaggatggct cagatgaggg cgtgaacagc     3000

aagaacattg tgccgggcaa cggcaagatc acaacacagc ttaagcagga ctggggcctg     3060

aacgatgtgt ggaacgatct gattctgcca aggttcgaga ggatgaacca gctgaccaac     3120

agcaaggtgt tcaccgcctg gaacgagaac taccagaagt tcctgccaac cgtgccaatc     3180

gagtacagca agggcttcag caagaagagg atcgatcaca ggcatcatgc tctggatgct     3240

ctggtgatcg cctgcgctac aaaggatcac gtgaacctgc tgaacaacca gagcgccaag     3300

agcgacacaa agaggtacga cctgaagaag aagagcatga agttcgagaa ggtggtgtac     3360

aacgacgcca agaccggcga gaagattgag agggaggtgc cgaagcagtt cctaaagcca     3420

tgggagaact tcacactgga cgtgaagcac aacctggaga ccatcatcgt gagcttcaag     3480

cagaacctga gggtgatcaa caaggccacc aactactacg agaagtacgt ggagaaggac     3540

ggcaccaaga acaaggagag ggtggagcag acaggcacaa attgggccat ccgcaagcca     3600

atgcacaagg atacagtgtc tggcaaggtg gatctgccat gggttaaggt gccaaagggc     3660

aagatcctga cagccacaag gaagagcctg gatagcagct tcgatctgaa gagcatcggc     3720

tctatcacag acaccggcat ccagaagatc ctgaagaact acctggcctt caaggatggc     3780

aatccagagc tggctttctc tccagagggc atcgacgacc tgaacaagaa catcgagaag     3840

tacaacgacg gcaagccaca ccagccaatc aataaggtgc gcgtgttcga gctaggctct     3900

aagttccagg ttggccagag cggcaacaag aaggataagt acgttgaggc cgccaagggc     3960

acaaatctgt tcttcgctgt gtacgaggat gagaagggca agcgcaacta cgagacaatc     4020

ccactgaacg aggtgatcga aaggcagaag cagggcctgt ctgttgtgga tctgaagggc     4080

accaacgatt tctacctgtg cccgaacgac ttcgtgtaca ttccatctgg cgacgagctg     4140

gagaacatca acaacgtgga cttcaaggac atcaagaagg agatcaacga gcgcatctac     4200

aaggtggtga gcttcaccgg caacaggctg agctgcatcc catacatggt ggccaccacc     4260

atcgtgaaca agctggagtt cacccagctg aacaagatcg agttcaccaa ggagaaggag     4320

atctgcatca agctgaacgt ggacaggctg ggcaacatca gcaaggcc                  4368


<210> 183
<211> 3210
<212> DNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG05083.1 Native Seq"

<400> 183
atgagagagt tggattatcg cataggatta gatattggaa cgaattctat tggctggggg       60

atcattgaat tatcttggaa caaagataga gaacaatatg agaaagcaag aattgtcgac      120

aagggtgttc gtatgtttga taaggctgaa atacctaaga ctggtgcttc tcttgctgaa      180

ccgaggcgta tagcacgctc atcacgtaga agattaaatc gcaaaagcca gagaaaaaaa      240

gatatacgta atttactcgt tcaacatgaa attattagtc aaaaggaatt ggcttcgtta      300

tatcccctga caaaaagttc aatggatatt tgggatattc gcttggatgg attagatcgc      360

ttgttagacc gttttgaatg gactcgatta ttaattcatt tagcgcaaag acgcggtttt      420

aaatcaaatc gaaagtctga actgaaagat gtggagacag gaaaagtatt atcaagtatt      480

caagcaaatg aaaaacgatt atcactgtac cgtacagtgg gagagatgtg gatgaagaat      540

gaagatttta gtaaatatga caaaaggcgt aattcttcta atgagtatgt attttcggtt      600

agccgtgcag atttagaaaa agaaattgtg acactatttg aagcgcaaag aaaatttcag      660

tcatcatatg catcggctga tttacaaaaa acatacttac aaatttgggc acaccaactt      720

ccttttgctt ctgggaatgc aattgtaaat aaagtaggat attgttcatt attaaaaggg      780

aaagaaaaga gagttccgaa agcaacatat acttttcaat atttcagtac actagatcaa      840

ataaatcgaa cacgattagg tcctaatttc caaccattta cgaaggaaca gagagacgtt      900

attttagatg aaatgtttaa tcgaacagat tattataaaa aaaagacaat acccgaagtc      960

acttactatg atattcggaa atggttagca ttagatgaaa caattcaatt taaaggactt     1020

acctatgacc caaatgaaga gctgaaaaaa atagaattga aatcctttat taatttaaag     1080

ccattctatg aaattaaaaa ggtagttact aattacgcca aaaaaacaaa tgaggcattc     1140

tcaacattag actatgatac atttgcatat gctttaacag tttataaaac ggacaaagat     1200

attagatctt atttaaagaa atctaataat ttatcaaaat gttgctacga tgatcaatta     1260

atagaagagc tattaactct ctcctataca aagtttggtc atttatcatt taaagcaatt     1320

aatcatgtac tgccaattat gcaagaggga aggacttatc aggaagcaat acaccaatta     1380

ggatatgatg ccactaatct aaaaaaagaa aacagaagta tgttcttgcc cctttttccc     1440

gatgagataa caaatccaat tgttaaaaga gcactaactc aagcacgtaa agttgtaaat     1500

gctattatta gaagatatgg ttcccccaat tctgttcata ttgaactagc tcgtgagctt     1560

tctaaaagtc atgatgagag aacgaaaata atgaaagctc atgatgaaaa ttataagaaa     1620

aataaaggag ccatatcaat tttgattgag aatggaattt taaatccgac aggatatgat     1680

attgtacgtt ataagttatg gaaagagcaa ggagaacgat gtgcttattc gctaaaacag     1740

attcctgcta atacgttttt taatgaaatg aaaaaagagc gaagtggctc cccagttcta     1800

gagatagatc acattttacc gtatagtcag agttttattg atagttatca taataaagta     1860

ctagtttatg gagatgagaa tcaaaaaaag ggaaatcgaa ttccatatac ttatttttta     1920

gaaggaaata aggactggga aagctttgaa agctacgtac gattgaatag ttttttttct     1980

aaaaagaagc gcggatattt attgaaaaaa gcttacttgc caagagagag taacatgatt     2040

aaggagcgtc atttaaatga tactcgatat gctagtagct atttgaaaaa cttcattgag     2100

aaaaatttga aatttaaaga agttgaaggt agtacacgaa aaaaacatgt acagacggtt     2160

aacggtataa ttacagccca tcttcgaaaa agatggggat tagaaaaaga taggcaggaa     2220

acatatttgc atcatgcaat ggacgctatt attgttgctt gtacagacca tcatatggtc     2280

actaaagtaa cggagtacta tcaaataaaa gaaagtaata agtcaataag gaaaccatac     2340

tttcctttgc catgggtggg ctttagagag gaaattttat cacatttagc aaggcagcca     2400

attgctagaa aaattagtga ggaacttaaa attggatatc aatcatttga ttatatactt     2460

gtatcgcgaa tgccaaaaag atctgtcact ggagcagctc atgaacagac aatcatgaaa     2520

aaaggtggta tcgacaaaaa aggaaaaact attatcataa agcgtgtgta cttaaaggat     2580

attaagtttg atgagaatgg cgattttaaa atggttggaa aagaacagga tttagcaact     2640

tatgaagcga taaagcaaag atatatagag tatggaaaag aatcgaaaaa agcatttgaa     2700

acacctttat acaagcctag taaaaaagga aaaggaaacc tcattaaaaa gatcaaagta     2760

gaagtgcaaa ccaaatcttt tgttcgagaa gttaatgggg gcgtagctca aaatggtgat     2820

ttagtaagag tagatttgtt tgaaaaggat aatagatatt atatgatacc tatttatgta     2880

atggatactg ttcattccga actaccaaat aaagctgtaa caagcagtaa aggctatgag     2940

caatggttaa caatagataa cagctttacg ttcaaattca gtttatatcc ttatgattta     3000

gtacgacttg taaaaggtaa tgaagatcgt ttcctatatt ttagtaccct tgatattaat     3060

tcggatcgtc ttaatttcaa agatgtaaac aagccatcaa agcaggctga aaatcgttat     3120

agccttaaaa caattgagaa tttagaaaaa tatgaggttg gtgttttagg tgatttaagg     3180

tttgtgagac aagaaatacg taaaaatttt                                      3210


<210> 184
<211> 3210
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05083.1 E. coli optimized"

<400> 184
atgcgcgagc tagattatcg catcggcctg gatattggca ctaactcaat aggctggggc       60

atcatcgaac tgagctggaa taaagaccgc gagcagtatg aaaaggcgcg catcgtggat      120

aaaggcgtgc gcatgttcga caaagcggaa attccgaaaa ccggtgcaag tctggcggaa      180

ccaagacgta ttgcacgtag tagtcgccgc cgattaaacc gcaaaagtca gcgcaagaag      240

gatataagga acctgctggt ccagcatgaa atcatcagcc agaaggaact ggcgagcctg      300

tacccgctga ccaaatcaag tatggacatc tgggatataa ggctggacgg cctggatcgt      360

ctgctggatc gctttgaatg gacccgccta ttaatccatc tggcacagcg ccgtggcttc      420

aaatcaaacc gcaagagcga attaaaggac gtggagaccg gtaaagtgct gtcaagcatt      480

caggcgaatg aaaagcgcct gagcctgtat cgtaccgtgg gcgagatgtg gatgaaaaac      540

gaggacttct caaaatacga taaaaggcgc aacagcagca acgagtacgt gttcagcgtg      600

agccgcgcgg acctggagaa agaaatcgtg accctgtttg aggcgcagcg caaattccaa      660

tcaagctatg cgagcgcgga tctgcagaaa acctacctgc agatttgggc acatcagctg      720

ccgtttgcaa gcggtaacgc gatcgtgaat aaagtgggct attgcagcct attaaaaggc      780

aaagaaaaac gcgtgccgaa agcgacctat acattccagt acttcagcac cctggaccaa      840

atcaaccgca cccgcctggg cccgaacttc cagccgttca ccaaagaaca gcgcgacgtg      900

atcctggatg aaatgttcaa ccgcaccgac tactataaaa agaaaaccat cccggaggtg      960

acatactacg atataaggaa atggctggcg ctggatgaaa ccatccagtt caaaggctta     1020

acctacgatc cgaacgagga attaaagaag atcgaattaa aatcgttcat taatctgaaa     1080

ccgttctatg aaattaaaaa ggtggtaacc aactacgcga agaaaaccaa cgaagcattc     1140

agcaccctgg actacgatac attcgcgtac gcgctgaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaagaa atcaaacaac ctgagcaaat gctgctacga cgaccaatta     1260

atcgaagaac tgctgaccct gagctacacc aaattcggcc acctgagctt caaagcgatc     1320

aaccacgtgc tgccgatcat gcaggaaggc cgcacctacc aggaagcgat ccaccagctg     1380

ggctacgatg cgaccaacct gaaaaaggaa aaccgcagca tgttcctgcc gctgttccct     1440

gatgaaatca ccaacccgat cgtgaaacgc gcgctgaccc aggcgcgcaa ggtggtgaac     1500

gcgatcatcc gccgctacgg ctcaccgaac agcgtgcaca tcgaactggc gcgcgaactg     1560

agcaaaagcc acgatgaacg caccaaaatc atgaaagcgc acgatgaaaa ctacaaaaag     1620

aacaaaggcg cgatcagcat cctgatcgaa aacggcatcc tgaacccgac cggctacgat     1680

atcgtgcgct acaaactgtg gaaagaacag ggcgaacgct gcgcgtacag cctgaaacag     1740

atcccggcga acaccttctt caacgaaatg aaaaaggaac gctcaggcag cccggtgctg     1800

gaaatcgatc acatcctgcc gtacagccag agcttcatcg atagctacca caacaaagtg     1860

ctggtgtacg gcgatgaaaa ccagaaaaag ggcaaccgca tcccgtacac ctacttcctg     1920

gaaggcaaca aagattggga gagcttcgaa agctacgtgc gcctgaacag cttcttcagc     1980

aaaaagaaac gcggctacct gctgaaaaag gcgtacctgc cgcgcgaaag caacatgatc     2040

aaagaacgcc acttaaacga tacccgctac gcgagcagct acctgaaaaa cttcatcgag     2100

aaaaacctga aattcaaaga agtggaaggc agcacccgta aaaagcatgt ccagaccgtg     2160

aacggcatca tcaccgcgca tctgcgcaaa cgctggggcc tggaaaaaga tcgccaggaa     2220

acctatctgc atcatgcgat ggatgcgatc atcgtggcgt gcaccgatca tcatatggtg     2280

accaaagtga ccgaatatta tcagatcaaa gaaagcaaca aatcaatccg caaaccgtat     2340

tttccgctgc cgtgggtggg ctttcgcgaa gaaatcctga gccatctggc gcgtcagccg     2400

atcgcgcgta aaatcagcga agaactgaaa atcggctatc agagctttga ttatatcctg     2460

gtgagccgca tgccgaaacg cagcgtgacc ggcgcggcgc atgaacagac catcatgaaa     2520

aagggcggca tcgataaaaa gggcaaaacc atcatcatca aacgcgtgta tctgaaagat     2580

atcaaatttg atgaaaacgg cgattttaaa atggtgggca aggaacagga cttagcgacc     2640

tacgaagcga tcaaacagcg ctacatcgag tacggcaaag agagcaaaaa ggcgtttgaa     2700

accccgctgt acaaaccgag caaaaagggc aagggcaacc tgatcaaaaa gatcaaagtg     2760

gaagtccaga ccaaatcgtt tgtgcgcgaa gtgaacggcg gcgtggcgca gaacggcgat     2820

ctggtgcgcg tggatctgtt tgaaaaagat aaccgctact atatgatccc gatctacgtg     2880

atggataccg tgcatagcga gctgccgaac aaagcggtga ccagcagcaa aggctatgaa     2940

cagtggttaa ccatcgataa cagctttacc ttcaaattca gcctgtatcc gtacgacctg     3000

gtgcgcctgg tgaaaggcaa cgaagatcgc ttcctgtatt tcagcaccct ggacatcaac     3060

agcgatcgcc tgaacttcaa ggacgtgaac aaaccgagca aacaggcgga aaaccgctat     3120

agcctgaaga ccatcgagaa cctggagaaa tatgaagtgg gcgtgctggg cgatctgcgc     3180

tttgtgcgcc aggaaattcg caaaaacttc                                      3210


<210> 185
<211> 3213
<212> DNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG07433.1 Native Seq"

<400> 185
atgagggagt tggactatcg catagggtta gatattggga cgaattctat tggatggggt       60

gttattgaat tatcctggaa caaggacaga gaacgatatg aaaaagtaag gattgtcgac      120

cagggtgttc gtatgtttga tagggctgaa atgccaaaaa caggtgcttc tcttgctgaa      180

ccgaggcgta tagcacgttc atcacgtaga aggttaaatc gtaaaagtca gaggaagaaa      240

aatatacgta atttacttgt tcaacatggg gtgattactc aagaagagct ggattcgtta      300

tatcctcttt caaaaaaatc aatggatatt tggggtattc gattggatgg attagatcgt      360

ctgctaaatc attttgaatg ggctcgatta ttaattcatt tagctcaaag acgtggtttt      420

aaatcgaatc gtaagtctga actgaaagat acggagacgg ggaaggtatt atcgagtatt      480

caattaaatg aaaaacgatt atcactgtac cgtacagtgg gagaaatgtg gatgaaagat      540

cctgatttta gtaagtatga tagaaaacgg aattctccta atgagtatgt attttcggtt      600

agtcgtgcgg aactagaaaa ggaaatagtt actttatttg cagcacaaag aaggtttcag      660

tcaccatacg catcgaagga tttacaagaa acatatttac aaatttggac acaccaactt      720

ccctttgctt ctgggaatgc aattttaaat aaagtgggat attgttcatt attgaaaggg      780

aaagaaagaa gaattccgaa agcaacatat acttttcagt attttagtgc actagatcaa      840

gtgaatcgaa cacgattagg acctgatttt cagccattta cgaaggaaca aagagaaatt      900

attttaaata acatgtttca acgtacagat tattataaaa aaaagactat acctgaagtt      960

acatactatg atatccggaa atggctagaa ctagatgaaa ctattcaatt taaaggactt     1020

aattatgatc caaacgaaga attgaaaaaa atagaaaaga aaccatttat taatttaaag     1080

gcattctatg aaattaataa ggtagtcgca aattattctg agagaacaaa tgagacattt     1140

tcaacgttag actatgatgg gattggatat gctttaacag tttataaaac ggacaaagat     1200

attaggtctt atttgaagag ctctcataat ttacctaaac gttgttacga tgatcaatta     1260

atagaggaac tattaagtct ttcttataca aagtttggtc acttatcact gaaagcaatc     1320

aatcacgtac tatcgattat gcaaaaaggc aatacttata aagaagcagt agaccagtta     1380

gggtatgata caagcggttt aaagaaagaa aaaagaagta agttcttgcc tcctatttca     1440

gatgagataa cgaatccaat tgttaaaaga gcgttaacac aagcgcgtaa agttgtgaat     1500

gctataatta gaagacatgg ttctccacat tcagttcata ttgaactggc tcgtgaactt     1560

tctaaaaatc atgacgagag aacaaaaata gtgtcagctc aagatgaaaa ttataagaag     1620

aataaagggg ctatatcaat tttaagtgag catggaattt tgaatccaac aggctatgat     1680

attgttcgtt ataagttatg gaaagaacaa ggagaacgat gtgcttattc gttaaaggag     1740

attcctgcgg atacgttttt taatgaatta aaaaaagaac gaaatggtgc tccaattcta     1800

gaggtagatc acattttacc gtacagtcaa agttttattg atagttatca taataaagta     1860

ttagtttaca gtgatgaaaa tcgaaaaaag gggaatcgaa ttccatatac ctatttttta     1920

gagacaaata aggattggga agcttttgaa agatatgtaa gatcaaataa atttttttct     1980

aaaaagaagc gtgagtattt attgaaaaga gcatatttgc caagagaaag tgaactgata     2040

aaggagcgac atttaaatga tacgcgatat gctagtacct ttttgaaaaa cttcattgag     2100

cagaatttgc aatttaaaga agctgaagat aatccgcgta aaagacgtgt acaaacagtt     2160

aacggtgtaa ttacagcaca ttttcgaaaa agatggggat tagaaaaaga tagacaagaa     2220

acatacttac atcatgcaat ggacgctatc attgttgctt gtacagacca tcatatggtt     2280

actagagtaa cagagtatta tcaaataaaa gaaagtaata aatcagtaaa gaaaccgtat     2340

tttcctatgc catgggaggg ctttagagat gaactcttat cacatttagc gagtcagcca     2400

atagctaaaa aaattagtga ggagcttaaa gctggatatc aatcattaga ttatatattt     2460

gtgtctcgaa tgccaaaaag atctatcact ggagcagcac ataaacaaac gatcatgaga     2520

aaaggcggta ttgataaaaa aggaaaaact attattatag agcgtttgca tttaaaggat     2580

attaagtttg atgagaatgg tgattttaaa atggttggca aagaacaaga tatggcaact     2640

tacgaggcga taaagcaaag atatttggag catggaaaaa actcgaaaaa agcatttgaa     2700

acacctctat acaaacctag taaaaaagga acaggaaatc ttattaaaag agttaaagtt     2760

gaaggacaag ctaaatcttt tgttcgagaa gtaaatgggg gcgtagccca aaatggtgat     2820

ttagtgagag ttgatttatt tgaaaaagat gataaatatt acatggtgcc tatttatgta     2880

ccagataccg tttgttcaga attacccaaa aaagttgtgg caagtagtaa gggttatgag     2940

caatggttaa cactagataa cagctttacg tttaaattta gtttataccc ttatgattta     3000

gtacggcttg taaaagggga cgaagatcgt ttcttatact ttggtactct cgatatcgat     3060

tcagatcgtc ttaattttaa agatgtaaat aagccatcaa aaaagaatga atatcgttat     3120

agccttaaaa caattgagga tttagaaaaa tatgaggtgg gtgttttagg agatttaagg     3180

ttagtaagaa aagaaacacg tagaaatttt cac                                  3213


<210> 186
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07433.1 E. coli optimized"

<400> 186
atgcgcgagc tagattatcg catcggcctg gatattggca ctaactcaat aggctggggc       60

gtgatcgaac tgagctggaa taaagaccgc gagcgctatg aaaaggtgcg cattgtggat      120

cagggcgtca gaatgtttga tcgtgcggaa atgccgaaaa ccggtgcatc actggcagaa      180

ccaagacgta tagcacgtag tagtcgccgc cgattaaacc gtaaaagcca gcgcaagaaa      240

aatatccgca acctgctggt tcagcatggc gtcatcaccc aggaagaact ggatagcctg      300

tacccgctga gcaagaaatc aatggacatc tggggcattc gtctggatgg tctggaccgc      360

ctattaaacc actttgaatg ggcccgccta ttaattcatc tggcgcagcg ccgcggcttc      420

aaatcaaacc gcaagagcga attaaaggac accgagaccg gtaaagtgct gtcatcgatc      480

cagctgaatg aaaaacgcct gagcctgtat cgcaccgtgg gcgagatgtg gatgaaagac      540

ccggacttct caaaatacga ccgcaaacgc aacagcccga acgaatacgt gtttagcgtt      600

agccgtgcgg aactggagaa agaaatcgtg accctgtttg cagctcagcg ccgttttcag      660

agcccgtatg cgagcaaaga tctgcaagaa acctacctgc agatctggac ccatcagctg      720

ccgtttgcaa gcggtaacgc gatattaaac aaagtgggct attgcagcct attaaaaggc      780

aaagaacgcc gcatcccgaa agcgacctat acattccagt acttcagcgc gctggaccag      840

gtgaaccgta cccgtctggg tccggatttt cagccgttca ccaaagaaca gcgcgagatc      900

atattaaaca acatgttcca gcgcaccgac tactataaaa agaaaaccat cccggaggtg      960

acatattacg atataaggaa atggctggaa ctggatgaaa ccatccagtt caaaggcctg     1020

aactacgatc cgaacgagga gctgaaaaaa atcgagaaaa aaccgttcat taatctgaaa     1080

gcgttctatg aaatcaacaa agtggtggcg aactacagcg aacgcaccaa tgaaaccttc     1140

tcaaccctgg attacgatgg catcggctac gcgctgaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaaatc aagccacaac ctgccgaaac gctgctacga cgaccaatta     1260

atcgaagaac tgctgagcct gagctatact aagttcggcc acctgtcatt aaaagcgatt     1320

aatcacgtgt taagcatcat gcagaaaggc aacacatata aagaagcggt ggatcagctg     1380

ggctacgata ccagcggatt aaaaaaagaa aaacgcagca aattcctgcc gccgatcagc     1440

gatgaaatca ccaacccgat cgtgaaacgc gcgctgaccc aggcgcgcaa agtggtgaac     1500

gcgatcatcc gccgccacgg cagcccgcac agcgtgcaca tcgaactggc gcgcgaactg     1560

agcaaaaacc acgatgaacg caccaaaatc gtgagcgcgc aggatgaaaa ctacaaaaag     1620

aacaaaggcg cgatcagcat cctgtcagaa cacggcatcc tgaacccgac cggctacgat     1680

atcgtgcgct acaaactgtg gaaagagcag ggcgaacgct gcgcgtacag cctgaaagaa     1740

atcccggcgg ataccttctt caacgagctg aaaaaagaac gcaacggcgc cccgatcctg     1800

gaagtggatc acatcctgcc gtacagccag agcttcatcg atagctacca caacaaagtg     1860

ctggtgtaca gcgatgaaaa ccgcaaaaaa ggcaaccgca tcccgtacac ctacttctta     1920

gagaccaaca aagattggga agcgttcgaa cgctacgtgc gcagcaacaa gttcttcagc     1980

aaaaagaagc gcgagtacct gctgaaacgc gcgtacctgc cgcgcgaaag cgaactgatc     2040

aaagaacgcc atctgaacga tacccgctac gcgagcacct tcctgaaaaa cttcatcgaa     2100

cagaacctgc agttcaaaga agcggaagat aacccgcgca aacgccgcgt ccagaccgtg     2160

aacggcgtga tcaccgcgca ttttcgcaaa cgctggggct tagaaaaaga tcgccaggaa     2220

acctatctgc atcatgcgat ggatgcgatc atcgtggcgt gcaccgatca tcatatggtg     2280

acccgcgtga ccgaatatta tcagatcaaa gaaagcaaca aaagcgtgaa aaaaccgtat     2340

tttccgatgc cgtgggaagg ctttcgcgat gaactgctga gccatctggc gagccagccg     2400

atcgcgaaaa aaatcagcga agaactgaaa gcgggctatc agagcctgga ttatatcttt     2460

gtgagccgca tgccgaaacg ctcaatcacc ggcgcggcgc ataaacagac catcatgcgc     2520

aaaggcggca tcgataaaaa aggcaaaacc atcatcatcg aacgcctgca tctgaaagat     2580

atcaaatttg atgaaaacgg cgattttaaa atggtgggca aagaacagga catggcgacc     2640

tacgaagcga tcaaacagcg ctatctggag catggcaaga acagcaaaaa agcgtttgag     2700

accccgctgt acaaaccgag caaaaaaggc accggcaacc tgatcaaacg cgtgaaagtg     2760

gaaggccagg cgaaatcatt tgtgcgcgaa gtgaacggcg gcgtggcgca gaacggcgat     2820

ctggtgcgcg tggatctgtt tgaaaaagat gacaaatatt atatggtgcc gatctatgtg     2880

ccggataccg tgtgtagcga actgccgaaa aaagtggtgg cgagcagcaa aggctatgaa     2940

cagtggctga ccctggataa cagctttacc ttcaaattca gcctgtatcc gtatgatctg     3000

gtgcgcctgg tgaaaggcga tgaagatcgc tttctgtatt ttggcaccct ggacatcgat     3060

tcagatcgcc tgaacttcaa ggacgtgaac aaaccgagca aaaagaacga atatcgctat     3120

agcctgaaaa ccattgaaga tctggaaaaa tatgaagtgg gcgtgctggg cgatctgcgc     3180

ctggtgcgca aagagacccg ccgcaacttt cat                                  3213


<210> 187
<211> 3213
<212> DNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG07513.1 Native Seq"

<400> 187
atgagagagt tggattatcg cataggatta gatattggaa cgaattctat tggctggggt       60

gttattgaat tatcttggaa caaagataga gaacaatatg agaaaacgag aattgtcgac      120

aagggtgttc gtatgtttga taaggctgaa atacctaaga ctggtgcttc tcttgctgaa      180

ccgagacgta tagcgcgctc atcacgtaga aggttaaatc gtaaaagcca gagaaaaaaa      240

gatatacgta atttacttgt tcaacatgaa attattagcc aaaaggaatt gacttcgtta      300

tatcccctgt caaaaagttc aatggatatt tgggatattc gcttagatgg attagatcgc      360

ttgttagacc gttttgaatg ggctcgatta ttaattcatt tagcacaaag acgcggtttt      420

aaatcaaatc gaaagtctga actgaaagat gtggagacag gaaaagtatt atcaagtatt      480

caagtaaatg aaaaacgatt atctctgtac cgtacagtgg gagagatgtg gatgaagaat      540

gcggattgta gtaaatatgg caaaaggcgt aattctccta atgagtatgt attttcggtt      600

agccgtgcag atttagaaaa ggaaattgtg actctatttg aggcgcaaag aaaattccat      660

tcatcatatg catcggttga tttacaaaaa acatatatac aaatttgggc acaccaactt      720

ccttttgctt ctgggaatgc aattgtaaat aaagtaggat attgttcatt attaaaaggt      780

aaagaaaaga gagttccaaa agcaacatat acttttcaat atttcaatac actagatcaa      840

ataaaccgaa cacgattagg gcccaatttc caaccattta cgaaggaaca gagagacata      900

attttagata aaatgtttca acggacagat tattataaaa aaaagacaat acccgaagtt      960

acttactatg atattcggaa atggttagca ctagatgaaa caattcaatt taaaggactt     1020

acctatgacc caaacgaaga gctgaaaaaa atagaaatga aaccctttat taatttaaag     1080

ccattctatg aaattaaaaa ggtagttact aattacgcaa aaaaaacaaa tgaggtattc     1140

tcagcattag attatgatac agttgcatac gctttaacag tttataaaac ggacaaagat     1200

attagatctt atttgaagag atctaataat ttatcaaaac gttgctacga tgatcaatta     1260

atagaagagc tattaactct ctcctataca aagtttggtc atttatcatt taaagcaatt     1320

aatcatgtac tgccaattat gcaagaggga aggacttatc aggaagcaat acaccaatta     1380

gggtatgata ccactaatct taaaaaagaa aacagaagta tgttcttgcc tattattcca     1440

gatgagataa caaatccaat tgttaaaaga gcgttaactc aagcacgtaa agttgtaaat     1500

gctattatta gaagatatgg ttctccaaat tctgttcata ttgaactagc tcgtgagctt     1560

tcgaaaagtc atgacgagag aaaaaaaata atgacagctc atgatgaaaa ttataagaaa     1620

aataaaggag ctgtatcaat tttgatcgat aatggaattt taaatccgac aggatatgat     1680

attgtacgtt ataagttatg gaaagagcaa ggagaacgat gtgcttattc gttaaaaaag     1740

attcctgcta atacgttttt taatgaattg aaaaaagagc gaagtggccc tccggttcta     1800

gaggtagatc acattttacc gtatagtcag agttttattg atagttacca taataaagta     1860

ttagtttatg gggatgaaaa tcaaaaaaag ggaaatcgaa ttccatatac ttttttttca     1920

gaagaagata aggagtggga aagctttgaa agctacgtaa gatcgaatag ttttttttct     1980

aaaaagaagc gcggatattt attgaaaaaa gcttacttgc caagagagag taacttgatt     2040

aaggagcgtc atttaaatga tacccgatat gctagtagct atttgaaaaa cttcattgag     2100

aaaaatttaa aatttaaaga agctgtaggt attacacgaa aaaaatatgt acagacggtt     2160

aacggtgtaa ttacagccca tctgcgaaaa aggtggggtt tagaaaaaga taggcaggaa     2220

acatatttgc atcatgcaat ggacgctatt attgttgctt gtacagatca tcatatggtc     2280

actaaagtaa cggagtacta tcaaataaaa gaaggtaata agtcaataaa gaaaccgtat     2340

tttcctttgc catggatggg atttagagag gaaattttat cacatttaga aagtcagcca     2400

attgctagaa aaattagtga ggaacttaaa attggatatc aatcacctga ttatatactt     2460

gtatcgcgaa tgccaaaaag atctgtcact ggatcagctc atgatcagac agtcatgaaa     2520

aaaggcgata tcgataaaaa aggaaagact attatcataa agcgtgtgca cttaaaggat     2580

attaagtttg atgagaatgg cgattttaaa atggttggca aagaacaaga tttagcaact     2640

tacgaagcga taaagcaaag atatttagag tatagaaaag aatcgaaaaa agcatttgaa     2700

acacctttat acaagcctag taaaaaagga aaaggaaacc tcattaaaaa aattaaagta     2760

gaagtgcaaa ccaaatcttt tgttcgagaa attaatgggg gcgtagctca aaatggtgat     2820

ttagtaagag tagatttgtt tgaaaaggat aataggtatt atatggtgcc tatttacgta     2880

gtagatactg ttcgttccga actaccaaat aaagctgtaa caagcagtaa aggctatgag     2940

caatggttat caatagataa cagctttacg ttcaaattca gtttatatcc ttatgattta     3000

gtacgacttg taaaaggcga tgaagatcgt tttctatact ttagtactct tgatattaat     3060

tcggaccgtc ttaattttaa agatgtaaat aagccatcaa agcaagctga atatcgttat     3120

agtcttaaaa caattgagaa tttagaaaaa tatgagattg gtgttttagg tgatttaagg     3180

ttagtgagac aagaaacacg taaaattttt aaa                                  3213


<210> 188
<211> 3213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG07513.1 E. coli optimized"

<400> 188
atgcgcgagc tagattatcg catcggcctg gatattggca ctaactcaat aggctggggc       60

gtgatcgaac tgagctggaa taaagaccgc gagcagtatg aaaagacccg catcgtggat      120

aaaggcgtgc gcatgttcga caaagcggaa attccgaaaa ccggtgcaag tctggcggaa      180

ccaagacgta ttgcacgtag tagtcgccgc cgattaaacc gcaaaagtca gcgcaagaag      240

gatatcagga acctgctggt ccagcatgaa atcatcagcc agaaggaatt aaccagcctg      300

tacccgctga gcaaatcaag tatggacatc tgggatataa ggctggacgg cctggaccgc      360

ctgctggatc gttttgaatg ggcccgccta ttaatccatc tggcacagcg ccgtggcttc      420

aaatcaaacc gcaagagcga attaaaggac gtggagaccg gtaaagtgct gtcaagcatt      480

caggtgaatg aaaagcgcct gagcctgtat cgcaccgtgg gcgagatgtg gatgaaaaac      540

gcggactgct caaaatatgg caaacgccgc aacagcccga acgaatacgt gtttagcgtt      600

agccgtgcgg acctggaaaa agaaatcgtg accctgtttg aggcgcagcg caaattccat      660

agcagctatg cgagcgtgga tctgcagaaa acatacatcc agatctgggc acatcagctg      720

ccgtttgcga gcggtaacgc gatcgtgaat aaagtgggct attgcagcct attaaaaggc      780

aaagaaaaac gcgtgccgaa agcgacctat acattccagt acttcaatac actggaccaa      840

atcaaccgca cccgcctggg cccgaacttc cagccgttca ccaaagaaca gcgcgatata      900

atcctggata aaatgttcca gcgcaccgac tactataaaa agaaaaccat cccggaggtg      960

acatactacg atataaggaa atggctggcg ctggatgaaa ccatccagtt caagggctta     1020

acctacgatc cgaacgagga gctgaaaaag atcgagatga aaccgttcat taatctgaaa     1080

ccgttctatg aaattaaaaa ggtggtaacc aactacgcga agaaaaccaa cgaagtgttc     1140

agcgcgctgg attacgatac cgtggcgtac gcgctgaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaaacg cagcaataat ctgagcaaac gctgctacga cgaccaatta     1260

atcgaagaac tgctgaccct gagctatact aagttcggcc acctgagctt caaagcgatt     1320

aatcacgtgc tgccaataat gcaggaaggc cgcacctacc aggaagcaat acaccagctg     1380

ggctacgata caaccaacct gaaaaaggaa aataggagca tgttcctgcc aataatcccg     1440

gatgaaatca ccaacccgat cgtgaaacgc gcgctgaccc aggcgcgcaa agtggtgaac     1500

gcaataatcc gccgctacgg ctcaccgaac agcgtgcaca tcgaactggc gcgcgaactg     1560

agcaaaagcc acgatgaacg caaaaagatc atgaccgcgc acgatgaaaa ctacaaaaag     1620

aacaaaggcg cggtgagcat cctgatcgat aacggcatcc tgaacccgac cggctacgat     1680

atcgtgcgct acaaactgtg gaaagaacag ggcgaacgct gcgcgtacag cctgaaaaag     1740

atcccggcga acaccttctt caacgaactg aaaaaggaac gctcaggccc gccggtgctg     1800

gaagtggatc acatcctgcc gtacagccag agcttcatcg atagctacca caacaaagtg     1860

ctggtgtacg gcgacgaaaa ccagaaaaag ggcaaccgca tcccgtacac cttcttcagc     1920

gaagaagaca aagaatggga gagcttcgaa agctacgtgc gcagcaacag cttcttcagc     1980

aaaaagaaac gcggctacct gctgaaaaag gcgtacctgc cgcgcgaaag caacttaatc     2040

aaagaacgcc atctgaacga tacccgctac gcgagcagct acctgaaaaa cttcattgag     2100

aaaaacctga aattcaagga agcggtgggc atcacccgca agaagtacgt ccagaccgtg     2160

aacggcgtga tcaccgcgca tctgcgcaaa cgctggggcc tggaaaaaga tcgccaggaa     2220

acctatctgc atcatgcgat ggatgcgatc atcgtggcgt gcaccgatca tcatatggtg     2280

accaaagtga ccgaatatta tcagatcaaa gaaggcaaca aatcaatcaa aaagccgtat     2340

tttccgctgc cgtggatggg cttccgcgaa gaaatcctta gccatctgga aagccagccg     2400

atcgcgcgca aaatcagcga agaactgaaa atcggctatc agagcccgga ttatatcctg     2460

gtgagccgca tgccgaaacg cagcgtgacc ggcagcgcgc atgatcagac cgtgatgaaa     2520

aagggcgata tcgataaaaa gggcaaaacc atcatcatca aacgcgtgca tctgaaagac     2580

atcaaattcg acgaaaacgg cgacttcaaa atggtgggca aggaacagga cttagcgacc     2640

tacgaagcga tcaaacagcg ctacctggaa taccgcaaag agagcaaaaa ggcgtttgaa     2700

accccgctgt acaaaccgag caaaaagggc aagggcaacc tgatcaaaaa gatcaaagtg     2760

gaagtccaga ccaaatcgtt tgtgcgcgag atcaacggcg gcgtggcgca gaacggcgat     2820

ctggtgcgcg tggatctgtt tgaaaaagat aaccgctatt atatggtgcc gatctacgtg     2880

gtggataccg tgcgcagcga actgccgaac aaagcggtga ccagcagcaa aggctatgaa     2940

cagtggttaa gcatcgataa cagcttcacc ttcaaattca gcctgtaccc gtatgatctg     3000

gtgcgcctgg tgaaaggcga tgaagatcgc ttcctgtatt ttagcaccct ggacatcaac     3060

agcgatcgcc tgaacttcaa agacgtgaac aaaccgagca aacaggcgga atatcgctac     3120

agcctgaaga ccatcgagaa cctggagaaa tacgaaattg gcgtgctggg cgatctgcgc     3180

ctggtgcgcc aggaaacccg caaaatcttc aaa                                  3213


<210> 189
<211> 3216
<212> DNA
<213> Bacillus sp.

<220>
<221> source
<223> /note="APG08290.1 Native Seq"

<400> 189
atgagtgagt tggattaccg catagggttg gatattggta cgaattccat tggctggggt       60

gttattgaat tattttggaa caaggacaga gaacgatatg aaaaagtaag gattgtcgac      120

aagggcgttc gtatgtttga taaggctgaa atacctaata agggtgcttc tcttgctgaa      180

ccgagacgta tagcgcgttc atcacgtaga aggttaaatc gcaaaagtca gaggaagaaa      240

gagatacgta atttacttgt tcaacacgga atgattaccc aagaggaatt ggatttgtta      300

tatcctcttt caaaaaaatc aatagatatt tgggatattc gtttggatgg attagatcgt      360

ctgttgaatc atcttgaatg ggctcgatta ttaattcatt tagcacaaag acgtggtttt      420

aagtcgaatc gaaagtctga attgaaagat gctgagacgg ggaaggtatt atcgagtatt      480

caagtaaatg aaaaacgact atttctgtac cgtacagtgg gggaaatgtg gataaaagat      540

gctgagttta gtaagtatga tagaagacgt aattctccta atgagtatgt attttcggtt      600

agtcgtgcgg acttagaaaa ggaaattgtt actctatttg aagcacaaag aaagtttcag      660

tcatcatacg catcgaagaa cttacaagaa acatatttac aaatttgggc acaccaactt      720

ccttttgctt ctgggaatgc aattttaaac aaagtaggct attgttcatt attgaaaggg      780

aaagaaagga gaattccgaa agcaacatat acttttcaat atttcagtgc actagatcag      840

gtgaatcgaa cacgattagg acctgatttt caaccattta cgcaggaaca gaaagagatt      900

attttagata aaatgtttca acgtacagat tattataaaa aaaagactat acctgaagtt      960

agctactatg atatacggaa atggctagag ttagatgaaa ctattcaatt taaaggactt     1020

aattatgatc caaacgaaga actgaaaaaa atagaaaaaa aaccatttat taatttaaag     1080

gcattctatg aaattaaaaa ggtagttgca aattatgctg agagaacaaa tgaggcattt     1140

tcaacgttag actatgatgc gattgcatat gctttaacag tttataaaac ggacaaagat     1200

attagatctt atttgaagaa atctaataat ttatcaaaac gttgctacga cgatcaatta     1260

atagaagagc tatttactct ctcctataca aagtttggtc atttatcatt taaagcaatt     1320

aatcatgtac ttccaattat gcaagaggga aggacttatc aagaagcgat acaccaatta     1380

ggatatgata ccactaatct taaaaaagaa aacagaagta tgttcttgcc tcttattcca     1440

gatgaaataa caaatccaat tgttaaaaga gcgataactc aagcacgtaa agttgtaaac     1500

gctattatta gaagatatgg ttctccaaat tctgttcata ttgaactagc tcgtgagctt     1560

tctaaaagtc atgacgagag aaagaaaata atgacggctc atgatgaaaa ttataagaaa     1620

aataaaggag ctatatccat tttgatcgag aatggaattt taaatccgac aggatatgat     1680

attgtacgtt ataagttatg gaaagagcaa ggagaacgat gtgcttattc gttaaaggag     1740

attcctccgg atacgttttt taatgaatta aaaaaagaac gaaatggttc tccaattcta     1800

gaggtagatc acattttacc gtatagccaa agttttattg atagttatca taataaagta     1860

ttagtttaca gtgatgaaaa tcgaaacaag ggaaatcgaa ttccatatac ctatttttta     1920

gagacaaata aggattggga agcttttgaa aggtatgtaa gatcaaataa gcttttttct     1980

aaaaagaagc gtgagtattt attgaaaaaa acatatttgc caagagagag tgaactaata     2040

aaggagcgac atttaaatga tacgcgatat gctagtacct ttttgaaaaa cttcattgag     2100

cagaacttgc aatttaaaga agttgaagtt aatctgcgta aaaaacgtgt gcaaacagtt     2160

aatggtgtaa ttacagcgca ccttcgaaaa agatggggat tagaaaaaaa tagacaggaa     2220

acatatctgc atcatgcaat ggacgctatc attgttgctt gtacagacca tcatatggtt     2280

actagaataa cagagtatta tcaaataaaa gaaagtaata aatcagtaaa gaaaccatat     2340

tttccgatgc catgggaggg ttttagagat gaactcttat cacatttagc gagccagcca     2400

attgctaaaa aaattagtga ggagcttaaa gctggatatc aatcatctga ttatatattt     2460

gtgtctcgaa tgccaaaaag atctgtcact ggagcagctc atgatcaaac gattaggaga     2520

aaaggtggta ttgataaaaa aggaaaaact attattataa agcgtgtgcg cttaaaggat     2580

attaagtttg atgagaatgg cgattttaaa atggttggaa aagaacaaga tttagcaact     2640

tatgaggcga taaagcaaag atatttggag catagaaaaa actcgaaaaa agcatttgaa     2700

acacctctat acaagcctag taaaaaaggg acaggaaatc tcatcaaaag agttaaaatt     2760

gaaggacaaa ctaaagcttt tgttcgagaa gtaaatgggg gagtagccca aaatagtgat     2820

ttagtaagag ttgatttatt tgaaaaagat gataaatatt acatggtgcc tatttatgta     2880

ccagataccg tttgttcaga attacccaaa aaagttgtga aaagtggtaa gggttatgag     2940

caatggctaa cactagataa cagctttacg tttaaatcta gtttataccc ttatgattta     3000

gtacgtcttg taaaaggtaa tgaagatcgt tttttatact ttggtactct cgatatcgat     3060

tctgaccgtc ttaattttaa agatgtaaat aagccatcaa aacagaatga atatcgttat     3120

agtcttaaaa caattgagaa tttagaaaaa tatgaggttg gtgttttagg tgatttaagg     3180

ttagtgaaac aagaaacacg tagaattttt aataga                               3216


<210> 190
<211> 3216
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG08290.1 E. coli optimized"

<400> 190
atgagcgagc tagattatcg catcggcctg gatatcggca ctaactcaat aggctggggc       60

gtgatcgaac tgttctggaa taaagaccgc gagcgctatg aaaaggtgcg catcgtggac      120

aaaggcgtca ggatgttcga caaagcggag atcccgaata aaggtgcatc actggcggaa      180

ccaagacgta tagcacgtag tagtcgccgc cgattaaacc gcaaaagtca gcgcaagaaa      240

gagatccgta acctgctggt tcagcatggc atgatcaccc aggaagaact ggatctgctg      300

tacccgctga gcaagaaatc aatcgacatc tgggatataa ggctggacgg cctggaccgc      360

ctattaaacc atctggaatg ggcccgccta ttaatccatc tggcgcagcg tagaggcttc      420

aaatcaaacc gcaagagcga attaaaggac gcggagaccg gtaaagtgct gtcaagcatt      480

caggtgaatg aaaagcgcct gttcctgtat cgcaccgtgg gcgagatgtg gattaaagac      540

gcggagttct caaaatacga ccgccgtcgc aacagcccga acgaatacgt gtttagcgtt      600

agccgtgcgg acctggagaa agaaatcgtg accctgtttg aagcgcagcg caaattccaa      660

tcaagctacg cgagcaagaa cctgcaagag acctacctgc agatttgggc acatcagctg      720

ccgtttgcaa gcggcaacgc gatattaaac aaagtgggct attgcagcct attaaaaggc      780

aaagaacgcc gcatcccgaa agcgacctat acattccagt acttcagcgc gctggaccag      840

gtgaaccgta cccgtctggg ccctgatttt cagccgttta cccaggaaca gaaagaaata      900

atcctggata aaatgttcca gcgcaccgac tactataaaa agaaaaccat cccggaagtg      960

tcatattacg atataaggaa atggctggag ctggatgaga ccatccagtt caagggcctg     1020

aactacgatc cgaacgagga gctgaaaaaa atcgagaaaa aaccgttcat taatctgaaa     1080

gcgttctatg aaattaaaaa agtggtggcg aactacgcgg aacgaaccaa cgaagcattc     1140

agcaccctgg attacgatgc gatcgcgtac gcgttaaccg tgtataaaac cgacaaggat     1200

ataaggagct acctgaaaaa atcaaacaac ctgagcaaac gctgctacga cgaccaatta     1260

atcgaagaac tgttcaccct gagctatact aagttcggcc acctgagctt caaagcgatt     1320

aatcacgtgc tgccaataat gcaggaaggc cgcacctacc aggaagcgat ccaccagctg     1380

ggctacgata ccaccaacct gaaaaaagaa aaccgcagca tgttcctgcc gctgatcccg     1440

gatgaaatca ccaacccgat cgtgaaacgc gcgatcaccc aggcgcgcaa agtggtgaac     1500

gcgatcatcc gccgctacgg ctcaccgaac agcgtgcaca tcgagctggc gcgcgagctg     1560

agcaaaagcc acgacgagcg caaaaaaatc atgaccgcgc acgacgagaa ctacaagaaa     1620

aacaaaggcg cgatcagcat cctgatcgag aacggcatcc tgaacccgac cggctacgat     1680

atcgtgcgct acaaactgtg gaaagaacag ggtgaacgct gcgcgtacag cctgaaagaa     1740

atcccgccgg ataccttctt caacgaactg aaaaaagaac gcaacggctc accgatcctg     1800

gaagtggatc acatcctgcc gtacagccag agcttcatcg atagctacca caacaaagtg     1860

ctggtgtaca gcgatgaaaa ccgcaacaaa ggcaaccgca tcccgtacac ctacttcctg     1920

gaaaccaaca aagattggga agcgttcgaa cgctacgtgc gcagcaacaa actgttcagc     1980

aaaaagaaac gcgaatacct gctgaaaaaa acctacctgc cgcgcgaaag cgaactgatc     2040

aaagaacgcc acttaaacga tacccgctac gcgagcacct tcctgaaaaa cttcatcgaa     2100

cagaacctgc agttcaaaga agtggaggtg aacctgcgta aaaagcgcgt ccagaccgtg     2160

aacggcgtga tcaccgcgca tctgcgcaaa cgctggggcc tggaaaaaaa ccgccaggaa     2220

acctatctgc atcatgcgat ggatgcgatc atcgtggcgt gcaccgatca tcatatggtg     2280

acccgcatca ccgaatatta tcagatcaaa gaaagcaaca aatcagtgaa aaaaccgtat     2340

tttccgatgc cgtgggaagg ctttcgcgat gaactgctga gccatctggc gagccagccg     2400

atcgcgaaaa aaatcagcga agaactgaaa gcgggctatc agagcagcga ttatatcttt     2460

gtgagccgca tgccgaaacg cagcgtgacc ggcgcggcgc atgatcagac catccgccgc     2520

aaaggcggca tcgataaaaa aggcaaaacc atcatcatca aacgcgtgcg cctgaaagat     2580

atcaaatttg atgaaaacgg cgattttaaa atggtgggca aagaacagga cttagcgacc     2640

tacgaagcga tcaaacagcg ctatctggag catcgcaaga acagcaaaaa agcgtttgag     2700

accccgctgt acaaaccgag caaaaaaggc accggcaacc tgatcaaacg cgtgaaaatc     2760

gagggccaga ccaaagcgtt tgtgcgcgaa gtgaacggcg gcgtggcgca gaacagcgat     2820

ctggtgcgcg tggatctgtt tgaaaaagat gacaaatatt atatggtgcc gatctatgtg     2880

ccggataccg tgtgtagcga actgccgaaa aaagtggtga aaagcggcaa aggctatgaa     2940

cagtggttaa ccctggataa cagcttcacc ttcaagagca gcctgtaccc gtatgatctg     3000

gtgcgcctgg tgaaaggcaa cgaagatcgc tttctgtatt ttggcaccct ggacatcgat     3060

agcgatcgcc tgaacttcaa agacgtgaac aaaccgagca agcagaacga ataccgctac     3120

agcctgaaga ccatcgagaa cctggagaaa tatgaagtgg gcgtgctggg cgatctgcgc     3180

ctggtgaaac aggaaacccg ccgcattttt aaccgc                               3216


<210> 191
<211> 4011
<212> DNA
<213> Enterococcus sp.

<220>
<221> source
<223> /note="APG05459.1 Native Seq"

<400> 191
atgaagaaag actacgttat tggtctggat atagggacta attctgtcgg ctgggcagtt       60

atgacagaag actatcagtt ggtgaagaaa aaaatgccta tttatggaaa cactgaaaaa      120

aagaaaatca agaaaaattt ttggggtgtg cgtttatttg aagaagggca tacagccgaa      180

gatcgccgat taaaaagaac agcacgacga agaattagtc gtcgacggaa tcgtttacgc      240

tacttacaag ctttttttga agaagcgatg acagctttgg atgaaaactt ttttgctcgt      300

ttacaagaga gttttttagt gcctgaagat aagaagtggc acagacatcc gatttttgct      360

aagttggaag atgaagtagc ttaccatgaa acgtatccga caatctacca tttacgcaaa      420

aaattagcag attcatctga gcaagcagat ttacgactaa tttatttggc gttggcacat      480

attgtcaaat atcgtggaca ttttttaatt gaaggaaaat taagtacaga aaatatttct      540

gttaaagaac aatttcaaca atttatgatc atttataacc aaacctttgt gaatggagag      600

agtcgcttag ttagtgcgcc attacctgaa tctgtcttga ttgaggaaga gttgactgaa      660

aaagcttctc gtactaaaaa atctgaaaaa gtcttacaac aatttcctca agaaaaagct      720

aatggcttat ttggtcagtt cttaaagcta atggtaggga ataaagctga ctttaaaaaa      780

gtttttggtt tggaagaaga agccaaaata acctacgcta gtgaaagcta tgaagaagat      840

ttagaaggca ttttagcaaa ggttggggat gaatatagtg acgtgttttt agctgctaaa      900

aatgtgtacg atgcagttga attatcaacg attttagcag attcggataa aaaaagtcac      960

gcgaaattat cttctagcat gattgtccgt tttacagaac atcaagaaga tttaaaaaaa     1020

ttcaaacgat ttattcgtga aaattgtcca gacgaatatg ataatctctt taaaaatgaa     1080

cagaaagacg gctatgcagg ctacattgca cacgcaggta aggtttcaca gcttaaattt     1140

taccagtatg ttaagaaaat cattcaagat attgctggag cagaatattt tttagaaaaa     1200

attgctcaag aaaacttttt aagaaagcaa cggacctttg ataatggggt gattcctcat     1260

caaattcatt tggctgagtt acaagcaatc attcatcgtc aagcggccta ttatccattt     1320

ttaaaagaaa atcaagaaaa aattgaacaa ctggttacat ttcgaattcc ttattatgtc     1380

ggaccattat caaaaggaga tgcaagtacc ttcgcttggc taaaacgtca aagtgaggaa     1440

ccaattcgac cttggaacct tcaagaaacc gttgatttgg accaatcagc gacagccttt     1500

attgaacgaa tgaccaattt tgatacgtat ttaccttctg aaaaagtttt accgaaacat     1560

agtttgttat atgaaaagtt tatggtattt aatgaattga ccaagatttc ttatacggat     1620

gatcgaggaa tcaaagccaa tttttcaggt aaagaaaaag aaaaaatctt tgattatctg     1680

tttaagacgc gtcgaaaagt taagaaaaag gatatcattc aattctatcg aaacgaatat     1740

aatacggaga ttgtcacgct tagtggactt gaagaagacc aatttaatgc tagttttagc     1800

acgtatcagg atttactgaa atgtggttta acaagagctg aattagacca ccctgataat     1860

gccgaaaaat tggaagatat cataaaaatt ttaactattt ttgaagatcg gcaacgaatt     1920

cggacgcaac tttccacatt caaagggcag ttctcagcag aagtactaaa aaaattagaa     1980

cgcaagcact acactggctg gggaagattg tcgaaaaaat taatcaatgg tatctacgat     2040

aaagaatcgg gtaaaacaat tttggactat ttaattaaag atgatggggt ctcaaaacac     2100

tataatcgca attttatgca actgattaat gattcacaat tatcttttaa aaatgctatt     2160

caaaaagcac agtccagtga acatgaagaa acattaagtg aaactgtcaa tgaattagct     2220

ggtagtccag caataaaaaa aggaatttat caaagtttaa aaattgtcga tgaactagtc     2280

gcgattatgg gttatgcgcc caagcggatt gttgtcgaaa tggcacgtga aaatcaaacg     2340

actagcactg gcaagagaag atccatccaa cgcttgaaaa tagttgaaaa agcaatggcc     2400

gaaatcggca gcaatttatt aaaagaacaa ccaacgacta atgaacagtt acgagatacc     2460

cgtcttttcc tttactatat gcaaaatggt aaagatatgt acacgggaga tgaattatcg     2520

cttcatcgtt tatctcacta tgatattgat catattatcc cacaaagctt tatgaaagac     2580

gattcattgg ataacctagt tttagtgggc tctactgaaa atcgagggaa atccgatgat     2640

gtacctagca aggaagttgt taaggatatg aaagcttatt gggagaaatt atatgctgct     2700

ggcttaatta gtcaacggaa attccaacgt ctgaccaagg gggagcaagg tggcttgact     2760

ctcgaagaca aagcgcattt tatccaacga caattagtag aaactcgtca aattaccaaa     2820

aatgttgcag ggatcttaga tcaacgctac aatgctaatt caaaagagaa aaaagtccaa     2880

atcatcacct tgaaagctag tttaacgagc caatttcgtt cgatttttgg cttgtataaa     2940

gttcgtgaag tgaatgatta tcaccatgga caagatgctt atttaaactg tgtggtcgca     3000

accacgttat taaaagttta tcctaattta gcaccagaat ttgtttacgg agaatatcct     3060

aaattccagg cctttaaaga aaataaagcc acggcgaaga ctataattta tacaaatttg     3120

atgcgctttt tcacggaaga tgaaccacgg ttcatgaagg atggcgaaat tctttggagt     3180

aacagttatt taaaaaatat caaaaaagaa ttaaattacc atcaaatgaa tattgtcaaa     3240

aaagtagaag tgcaaaaagg cggtttttca aaagagtcga ttaaacccaa aggaccatcg     3300

aataaattga ttcctgtcaa aaatggtttg gatccccaaa aatatggcgg ttttgatagt     3360

cctgtagttg cttatacagt gttattcacg catgaaaaag gtaaaaaacc tcttattaaa     3420

caggagatac tgggcattac gattatggaa aaaacaaggt ttgaacaaaa tcctattctt     3480

tttttagagg agaaaggctt cctacggcct cgtgtattaa tgaaattgcc taagtataca     3540

ctgtatgaat ttccagaggg gcgcaggcgc ttattagcca gcgctaaaga agcgcaaaaa     3600

gggaaccaga tggttttacc tgaacattta cttacgttac tgtaccatgc gaaacaatgt     3660

ttgttaccaa atcaatcaga aagtttggct tatgtagaac aacatcaacc agaatttcaa     3720

gagattttag agagagtggt tgactttgct gaagtgcata cattagccaa gtcaaaagtc     3780

cagcaaattg tgaaactttt tgaagcaaat caaacagcag atgtgaaaga gattgcggca     3840

tcctttatcc aacttatgca gtttaatgcg atgggcgcac caagtacgtt taaatttttc     3900

caaaaagaca ttgagcgagc acgctacacg tcaatcaaag aaatttttga tgccactatc     3960

atttaccaat cgactacggg actgtatgaa acacgcagaa aggttgtcga c              4011


<210> 192
<211> 4011
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG05459.1 E. coli optimized"

<400> 192
atgaaaaagg actacgtgat cggcctagac atcggcacta acagcgttgg ttgggcggtg       60

atgaccgaag attaccagct agtgaagaag aagatgccta tctacggtaa tacagagaag      120

aagaagatta aaaagaactt ctggggcgtg aggctattcg aggagggtca caccgcggag      180

gaccgccgcc tgaagcgcac cgctagacgc cgtatttcac gtcgtcgtaa ccgtctgcgt      240

tacctgcaag cattcttcga agaagcaatg accgcgctgg atgaaaactt cttcgctagg      300

ctgcaggagt catttctggt gccggaggat aaaaagtggc accgtcatcc gatcttcgcg      360

aaactagaag acgaggtggc gtaccatgaa acctacccga ctatctacca cctgcgcaaa      420

aagctggcgg atagcagcga acaagcagac ctgcgattaa tctatctggc gctggcgcac      480

atcgtaaaat acagaggcca cttcctcatc gagggcaaat tatcgaccga aaatattagc      540

gtgaaggagc agttccagca gttcatgatc atctacaacc aaaccttcgt gaacggcgaa      600

tcaaggctgg tgagcgcgcc gctgccggag agcgtattaa ttgaggagga attaaccgag      660

aaagcgagcc gcactaagaa aagcgagaaa gtgcttcagc agttcccgca agaaaaagcg      720

aacggcctgt tcggccagtt cctgaaatta atggtgggca ataaagcgga cttcaaaaag      780

gtgttcggcc tggaagagga ggcgaaaata acctacgcga gcgaaagcta cgaggaagac      840

ctggagggca tactagcgaa agtgggcgac gaatacagtg acgtgttcct ggcggctaaa      900

aacgtgtacg acgcggtgga attaagcacc atactagcgg acagcgataa aaagagtcac      960

gcgaaattaa gctcaagcat gatcgtgcgc ttcaccgaac accaggaaga cctgaaaaag     1020

ttcaaacgct tcatccgcga aaactgcccg gacgaatacg ataacctgtt caaaaacgaa     1080

cagaaagatg gctacgcggg atacatcgcg cacgcgggca aagtgtcaca attaaagttc     1140

taccagtacg tgaagaaaat aatccaggat atcgcgggcg cggaatactt cctggagaaa     1200

atagcgcagg agaacttcct taggaaacag cgcaccttcg acaacggcgt gatcccgcac     1260

caaatacacc tggcggaact acaggcaata attcaccgcc aggcggcata ctacccgttc     1320

ctgaaagaga accaggagaa aatagaacag ctggtgacct tccgcatccc atactacgtg     1380

ggcccgctta gcaaaggcga tgcgagcacc ttcgcgtggc tgaaacgcca gagcgaagaa     1440

ccaatccgcc cgtggaactt acaagaaacc gtggatctgg atcagagcgc gaccgcgttc     1500

atcgaacgca tgaccaactt cgatacatac ctgccgagcg aaaaagtgct gccgaagcat     1560

agcctgctgt atgaaaaatt catggtgttc aacgaactga ccaaaataag ctacaccgat     1620

gatcgcggca ttaaagcgaa cttcagcggc aaagaaaaag agaaaatatt cgattaccta     1680

ttcaaaaccc gccgcaaagt gaaaaagaaa gacataatac agttctaccg caacgaatac     1740

aacaccgaaa tcgtgaccct gagcggcctg gaagaagatc agttcaacgc gagcttcagc     1800

acctaccagg acttattaaa atgcggcctg acccgcgcgg agcttgacca cccggacaac     1860

gcggaaaaac tggaagatat cattaaaata ctgaccatct tcgaagatcg ccagcgcatc     1920

cgcacccagc tgagcacctt caagggccag ttcagcgcgg aagtgctgaa aaagctggaa     1980

cgcaaacatt acaccggctg gggccgcctg agcaaaaagc tgatcaacgg catctacgat     2040

aaagaatcag gcaaaaccat cctggactac ctgatcaaag atgacggcgt gagcaaacac     2100

tacaaccgca acttcatgca gctgatcaac gatagccagc tgagcttcaa gaacgcgatc     2160

cagaaagcgc agagcagcga acatgaagaa accctgagcg aaaccgtgaa cgaactggcg     2220

ggcagcccgg cgatcaaaaa gggcatctat cagagcctga aaatcgtgga tgaattagtg     2280

gcgatcatgg gctatgcgcc gaaacgcatc gtggtggaaa tggcgcgcga aaaccagacc     2340

accagcaccg gcaaacgccg cagcatccag cgcctgaaaa tcgtggaaaa agcgatggcg     2400

gaaatcggca gcaacctgct gaaagaacag ccgaccacca acgaacagct gcgcgatacc     2460

cgcctgtttc tgtattatat gcagaacggc aaagatatgt ataccggcga tgaactgtca     2520

ctgcatcgcc tcagccatta tgatatcgat catatcatcc cgcagagctt tatgaaagat     2580

gatagcctgg ataacctggt gctggtgggc agcaccgaaa accgcggcaa aagcgatgat     2640

gtgccgagca aagaagtggt gaaagatatg aaagcgtatt gggaaaaact gtatgcggcg     2700

ggcctgatca gccagcgcaa atttcagcgc ctgaccaaag gcgaacaggg cggcctgacc     2760

ttagaagata aagcgcattt tatccagcgc cagctggtgg aaacccgcca gatcaccaaa     2820

aacgtggcgg gcatcctgga tcagcgctat aacgcgaaca gcaaagaaaa gaaagtccag     2880

atcatcaccc tgaaagcgag cctgaccagc cagtttcgca gcatctttgg cctgtataaa     2940

gtgcgcgaag tgaacgatta tcatcatggc caggatgcgt atctgaactg cgtggtggcg     3000

accaccttac tgaaagtgta tccgaacctg gcgccggaat ttgtgtatgg cgaatatccg     3060

aaatttcagg cgtttaaaga aaacaaagcg accgcgaaaa ccatcatcta taccaacctg     3120

atgcgcttct ttaccgaaga tgaaccgcgc tttatgaaag atggcgaaat tctgtggagc     3180

aacagctatc tgaaaaacat caaaaaggaa ctgaactacc accagatgaa catcgtgaaa     3240

aaggtggagg tccagaaagg cggcttctca aaggaaagca tcaaaccgaa aggcccgagc     3300

aacaaactga tcccggtgaa aaacggcctg gacccgcaga aatatggcgg ctttgatagc     3360

ccggtggtgg cgtataccgt gctgtttacc catgaaaaag gcaaaaagcc gctgatcaaa     3420

caggaaattc tgggcatcac catcatggag aaaacccgct ttgaacagaa cccgatcctg     3480

ttcctggaag aaaaaggctt tctgcgcccg cgcgtgctga tgaaactgcc gaaatatacc     3540

ctctatgaat ttccggaagg ccgccgccgc ctgctggcga gcgcgaaaga agcgcagaaa     3600

ggcaaccaga tggtgttacc ggaacatctg ctgaccctgc tgtatcatgc gaaacagtgc     3660

ctgctgccga accagagcga aagcctggcg tatgtggaac agcatcagcc ggaatttcag     3720

gaaattctgg aacgcgtggt ggattttgcg gaagtgcata ccctggcgaa aagcaaagtt     3780

cagcagattg ttaaactgtt tgaagcgaac cagaccgcgg atgtgaaaga aattgcggcg     3840

agctttattc agctgatgca gtttaacgcg atgggcgccc cgagcacctt caaattcttt     3900

cagaaagata ttgaacgcgc gcgctatacc agcattaaag aaatttttga tgcgaccatt     3960

atctatcagt caaccaccgg cctgtatgaa acccgccgca aagtggtgga t              4011


<210> 193
<211> 4308
<212> DNA
<213> Enterococcus sp.

<220>
<221> source
<223> /note="APG04583.1 Native Seq"

<400> 193
atggctaaaa atatacttgg attagatttg ggaaccaata gtattggttg ggcgttggta       60

cagcaagact ttgaaaacaa agaaggaaat attcttggaa tgggaagtag gattattccg      120

atgtcgcaag atattttagg agaattcggt aaggggaatt ctatttctca aactgctgaa      180

cgtactggtt atcgtggtgt ccgtcggtta agagaacgac atttattacg tcgtgagcgt      240

ttgcaccgag ttttgcattt gttgggtttc ttgccaaaac attatgatga aaaaatagat      300

tttacacaac gttttgggaa attcattaac caagccgaac ctaaattggc ttttgatagt      360

gaatttcttt ttaaagattc tttccatgaa atgttagctg attttaaaca aaatcaacca      420

gagtttttga aagataaaaa tggagaagat tgtttagttc cttatgattg gacgatttat      480

tatttacgta aaaaagcatt aacgcaaaaa attgagaaat atgaattagc ttggttgatt      540

cttaatttta atcaaaaacg tggttattat caattaagag gtgaagaaga gaaagaaaat      600

ccaaataaat tggtgggatt tcattctttg aaaatcgttg atgttattcc cgatgctgaa      660

acaaataaaa aaggagagac ttggtattct ttgcatttag aaaatggttg ggtatatcgc      720

cgttcttcta aaatttcatt agcggattgg aaagataaag ttcgagattt tattgttacg      780

actgatttaa acgatgatgg ttctgaaaaa ttggataaag atggaattgt gaaacgtagc      840

tttcgtgcac caagtgcgga tgattggact ttgttgaaaa agaaaacaga aaaagatatt      900

gataactcta acaaaactgt tggaacttat atttacgaca atcttttatt gaacccaaaa      960

caaaaaataa aaggaaaaat ggttcgtacc atcgaacgta agttttacaa gcaagaatta     1020

gaacaaattt taaaaactca aaaagaattt cattcagaat tacaaagtga aaatttgcta     1080

caagattgtg ttcgagaatt gtatcgaaat aatgaacaac atcaacaaat gttagaagct     1140

aaagattttg tgcatttgtt cctaaatgat attattttct atcaacgtcc tttgagaagt     1200

caaaaatcca gtatatcgaa ttgtactttg gaatttagaa aatcgaaaaa tgaaaatggt     1260

gaagaagtta ttcatcgttt aaaagtaatt gcaaaatcga atccatatta tcaggaattt     1320

agattgttac aatgggtgca aaatttagca atttatacaa aagatgatga taaaaatgta     1380

acaaacgaat ttctaaagtc tactcaagat tgggaggatt tattgagatg gctacattct     1440

aaaaaagaaa ttaaacagga tgctttaatt aagtttttga ttgaaaagaa aggtttaaaa     1500

ggcaaagctt taactattga agtagcaaaa tatcgttgga attatgttca ggacaaagat     1560

taccctggta atgaaacccg atatttaatt caatctcgtt tggataaagt tgaatatgca     1620

cctaaggatt ttttaactta tgaaaatgaa atggctttgt ggcacatcat ttattcgata     1680

aacgataaaa ttgagtacga aaaagcctta aaatcttttg ccaacaaaaa aggtttggac     1740

gaagtaactt ttgttgaagc gtttaagaaa ttcccgcctt ttaaaagtga ttacggaagt     1800

ttttctgaaa aagcaatcaa gaaattattg cctttgatgc gttttggaac tcaatggaat     1860

tgggataata tcgatcaaaa ttctaaagaa agaattggaa aaatattgac aggcgaatat     1920

gatgaaaaca tcaaaggtcg tgttcgcgaa aaagcaagac atctcaattc tgaaaccgat     1980

tttcaagctt tacctttgtg gttggcgcaa tacgtagttt acggaagaca ttctgaagct     2040

gatattgcag gtaaatggaa ttcggtggat gatttaaagc aatttttaga tgactttaaa     2100

caacattcgc ttcgtaatcc tattgtagag caagtgatta ctgaaacgtt gcgtgcggta     2160

aaagatattt ggaattttta tggaaaaggt gctaaagatt tcttctctga aattcatatc     2220

gagctggggc gtgaaatgaa aaatacggct gatgaacgca agcgtattac tacaatggtt     2280

acggataacg aaaacaccaa tttgcgtatc aaagctttgt tggctgaaat ggctttggat     2340

caaaatgtag ataatgttcg tccatattct ccaatgcaac aagaaatttt gaaaatctat     2400

gaagaaggtg ttttgaatgc tgaagaaaat atcgatgatg atattctgaa aattagtaaa     2460

acggctcaac cttctgctac agatttaaag cgttacaaat tgtggttaga acaaaaatat     2520

cgttcgcctt atacaggtca aatgattcct ttgaataagc tgtttacacc tgaatatgag     2580

attgaacaca taattccgca aagtcgctat tttgatgata gtatgagcaa taaagtgatt     2640

tgcgaagcag cggtgaataa acttaaagac aatcaaattg gtttggtttt cattaagaat     2700

catcacggag aagttgtgga tttcggaatg ggaaaacaag tgaagatttt ggaagtttcc     2760

gattatgagg attttgtaaa acaaaattac aataaaaaca gaggaaaacg taataagttg     2820

ttattggaag atattcctga gaaaatgatt gaacgtcaac taaatgatac acgttacatc     2880

agcaaatata ttacgcaagt gttatcgaat attgttcgtg atgataaaga aggtagtaaa     2940

gatgatggtg taaattctaa aaatattgtt cctggaaacg gaaaaattac cacaagactt     3000

aaacaagatt ggggattgaa tgacgtttgg aatgatttgg ttttacctcg ttttgaacga     3060

atgaatacat tgactaattc aaatgatttt acatcaaaaa atacacatgg aaaaacaatt     3120

ccaacagttc caattgagtt atccaaaggt ttttctaaaa aacgtatcga tcatcgtcat     3180

cacgcaatgg atgcgttggt aattgcctgt gcaacgagag atcacgtgaa tttgttgaat     3240

aacgaaagtt caaaatcgga tacaaaacgt tatgatttga ataggaaatt aagaaaatac     3300

gagaaagtag cttacaatga tcccaaaaca ggcgaacgaa ttgagaaaga agttccaaaa     3360

gacttcatta aaccttggga gacctttacc gaagatacgc gaactttgtt agaaaatatt     3420

gtaattagtt tcaagcaaaa tctacgagtt atcaataaag caaccaatta ttatgaaaaa     3480

attgagaatg ggaaaaaagt aaaagttgaa caaaagggaa taaattgggc tgtaagaaaa     3540

gctttgcata aagaaaccgt ttctggacaa gtgcatttgg atagaataaa agttgcaaaa     3600

ggtaaaatat taacggctac tcgtaaaact ttggatgcct cttttaatga aaaaacaatt     3660

gagtcaatta cggatacagg gattcaaaag attttattga attatttaaa atcaaaagat     3720

aacaatccag aggttgcatt ttcaccagaa ggaatagaag aattaaataa aaatattagg     3780

ctatataatg atggaaaagc acatcaacca attttgaaag ttcgtgtttt tgagcaagga     3840

agcaaattta ctttaggtga gacgggaaat aaaaccacta agtttgtaga agcagcaaag     3900

ggtactaatc tatttttcgg aatttatgaa gacaaatcag gtaagagaag ctacgaaacc     3960

attccattaa atattgtcat cgaaagacaa aaacaaggtc tgcaagctgt tcccgaaacc     4020

aatgagaaag ggaaacaatt gttgtttacg ttatctccaa atgatttggt ttacgttcct     4080

gaagaaggag tttttgatga gaataatatc aaggtagata ggatttataa ggtagtgagt     4140

ttttctacct atcaatgttt ttttgtaaga aatgatgttt ctacttctgt agttaataag     4200

gttgaatatt ccgctttaaa taaaatggaa aaatctattg acaacataat gataaaagaa     4260

aactgcgtca aactgaatgt agaccgttta ggaaagattt caaaagct                  4308


<210> 194
<211> 4308
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG04583.1 E. coli optimized"

<400> 194
atggcgaaga acatactagg cctggatctc ggaaccaaca gcattggttg ggcactggtc       60

cagcaggact tcgagaataa agagggcaac atactaggca tgggcagccg aataatccct      120

atgagtcagg acatactagg cgagttcggc aagggcaaca gcattagcca gaccgcagaa      180

cgtactggtt atcgtggtgt gcgccgttta cgtgaacgtc atctgttacg tcgtgaacgt      240

ctgcatcgtg ttctgcatct gttaggcttc ctgccgaagc attacgatga aaagatcgac      300

ttcacccagc gcttcggcaa gttcattaat caagcggaac caaagctggc gttcgacagc      360

gagttcctgt tcaaggacag cttccatgaa atgctagcgg acttcaagca gaatcaaccg      420

gagttcctga aggataaaaa cggcgaggac tgcctggtgc cgtacgactg gaccatatac      480

tacctgcgca agaaagcact gacccagaag atcgaaaaat acgagctagc gtggctcatc      540

ctgaacttca atcaaaagcg cggatactac cagcttaggg gcgaggagga gaaagagaac      600

ccgaataaac tggtgggctt ccacagcctg aaaatagtgg acgtgatccc ggacgcggaa      660

accaataaaa agggcgagac ctggtactca ctgcatctgg aaaacggctg ggtgtaccgc      720

cgcagcagca aaataagcct ggcggactgg aaagacaaag tgcgcgactt catcgtgacc      780

accgacctga acgatgacgg cagcgaaaaa ctggacaaag acggcatcgt gaaacgcagc      840

tttcgtgcac cgagcgcaga tgattggacc ctattaaaga aaaagaccga aaaagacatc      900

gacaacagca ataaaaccgt gggcacctac atctacgaca acctgttatt aaacccgaag      960

cagaaaatca aaggcaaaat ggtgcgcacc atcgaacgca aattctacaa acaggagctg     1020

gagcagatcc tgaaaaccca gaaggaattc cacagcgaac tgcagagcga aaacctgctg     1080

caggattgcg tgcgcgaact gtaccgcaat aatgaacagc accagcagat gctggaagcg     1140

aaagatttcg tgcacctgtt cctgaacgat ataatcttct accagcgccc gctgcgcagc     1200

cagaaatcaa gcatcagcaa ttgcaccctg gaattccgca aaagcaagaa tgaaaacggc     1260

gaagaagtga tccaccgcct gaaagtgatc gcgaaaagca acccatacta ccaggaattc     1320

cgcctgctgc agtgggtcca gaacctggcg atctatacta aagacgacga caagaacgta     1380

accaacgagt tcctgaaatc aacccaggac tgggaagatc tgctgcgctg gctgcatagc     1440

aagaaggaga ttaaacagga cgcgctgatc aagttcctga tcgagaaaaa gggcctgaag     1500

ggcaaagcat tgaccatcga ggtggcaaaa taccgctgga actacgtcca ggacaaagat     1560

tacccgggca atgaaacccg ctacctgatc caatcaaggc tggacaaagt ggaatacgcg     1620

ccgaaagatt tcctgaccta cgagaatgaa atggcgctgt ggcacatcat ctacagcatt     1680

aatgataaaa tcgaatatga aaaagcatta aaatcgttcg cgaataaaaa gggcctggat     1740

gaagtgacct tcgtggaagc attcaaaaag ttcccgccgt tcaaaagcga ttacggcagc     1800

ttcagcgaaa aagcgattaa aaagctgctg ccattaatgc gcttcggcac ccagtggaac     1860

tgggataaca tcgatcaaaa tagcaaagaa cgcatcggca aaatactaac cggcgaatac     1920

gatgaaaata ttaaaggccg cgtgcgcgaa aaagcgcgcc atctgaacag cgaaaccgat     1980

ttccaagcat tgccgctgtg gctggcgcag tacgtggtgt acggccgcca tagcgaagcg     2040

gatatcgcgg gcaaatggaa cagcgtggat gatctgaaac agttcctgga tgatttcaaa     2100

cagcatagcc tgcgcaaccc gatcgtggaa caggtgatca ccgaaaccct gcgcgcggtg     2160

aaagatatct ggaacttcta tggcaaaggc gcgaaagatt tcttcagcga aatacacatc     2220

gaactgggcc gcgaaatgaa aaataccgcg gatgaaagaa aacgcatcac caccatggtg     2280

accgataatg aaaataccaa cttacgcatt aaagcattgc tggcggaaat ggcgctggat     2340

cagaacgtgg ataacgtgcg cccgtatagc ccgatgcagc aggaaatcct gaaaatatat     2400

gaagaaggcg tattaaacgc ggaagaaaat atcgacgatg atatcctgaa aataagcaaa     2460

accgcgcaac caagcgcgac cgatctgaaa cgctataaac tgtggctgga acagaaatat     2520

cgcagcccgt ataccggcca gatgatcccg ctgaacaaac tgtttacccc ggaatatgaa     2580

atcgaacata tcatcccgca gagccgctat tttgatgata gcatgagcaa caaagtgatc     2640

tgcgaagcgg cggtgaacaa actgaaagat aaccagatcg gcctggtgtt tatcaaaaac     2700

catcatggcg aagtggtgga ttttggcatg ggcaaacagg tgaaaatcct ggaagtgagc     2760

gattatgaag attttgtgaa acagaactat aacaaaaacc gcggcaaacg caacaaatta     2820

ctgctggaag atatcccgga gaaaatgatc gaacgccagc tgaacgatac ccgctatatc     2880

agcaaatata tcacccaggt gctgagcaac atcgtgcgcg atgataaaga aggcagcaaa     2940

gatgatggcg tgaacagcaa aaacatcgtg ccgggcaacg gcaaaatcac cacccgcctg     3000

aaacaggatt ggggcctgaa cgatgtgtgg aacgatctgg tgctgccgcg ctttgaacgc     3060

atgaacaccc tgaccaacag caacgatttt accagcaaaa acacccatgg caaaaccatt     3120

ccgaccgtgc cgattgaact gagcaaaggc tttagcaaaa agcgcattga tcatcgccat     3180

catgcgatgg atgcgctggt gattgcgtgc gcgacccgcg atcatgtgaa cttactgaac     3240

aacgaaagca gcaaaagcga taccaaacgc tatgatctga accgcaaact gcgcaaatat     3300

gaaaaagtgg cgtataacga tccgaaaacc ggcgaacgca ttgaaaaaga agtgccgaaa     3360

gattttatta aaccgtggga aacctttacc gaagataccc gcaccctgct ggaaaacatt     3420

gtgattagct ttaaacagaa cctgcgcgtg attaacaaag cgaccaacta ttatgagaaa     3480

attgaaaacg gcaaaaaggt gaaagtggaa cagaaaggca ttaactgggc ggtgcgcaaa     3540

gcgctgcata aagaaaccgt gagcggccag gtgcatctgg atcgcattaa agtggcgaaa     3600

ggcaaaattc tgaccgcgac ccgcaaaacc ctggatgcgt cattcaacga gaaaaccatt     3660

gaaagcatta ccgataccgg cattcagaaa attctgctga actatctgaa aagcaaagat     3720

aacaacccgg aagtggcgtt tagcccggaa ggcattgaag aactgaacaa aaacattcgc     3780

ctgtataacg atggcaaagc gcatcagccg attctgaaag tgcgcgtgtt tgaacagggc     3840

agcaaattca ccctgggcga aaccggcaac aaaaccacca aatttgtgga agcggcgaaa     3900

ggcaccaacc tgttctttgg catctatgaa gataaaagcg gcaaacgcag ctatgaaacc     3960

attccgctga acattgtgat tgaacgccag aaacagggcc tgcaagcggt gccggaaacc     4020

aacgaaaaag gcaaacagct gctgtttacc ctgtcaccga acgatctggt gtatgtgccg     4080

gaagaaggcg tgtttgatga aaacaacatt aaagtggatc gcatctataa agtggtgagc     4140

tttagcacct atcagtgctt ctttgtgcgc aacgatgtga gcaccagcgt ggtgaacaaa     4200

gtggaatata gcgcgctgaa caaaatggaa aaatcgattg ataacattat gattaaagaa     4260

aactgcgtga aactgaacgt ggatcgcctg ggcaaaatta gcaaagcg                  4308


<210> 195
<211> 4368
<212> DNA
<213> Empedobacter sp.

<220>
<221> source
<223> /note="APG01688.1 Native Seq"

<400> 195
atgatgatta aaaatatact tggattagat ttggggacta actctattgg gtgggcattg       60

ataaaacaag attttgaaaa taagcatggc gaaattcttg gaatgggtag ccggattatt      120

ccgatgtcac aggatattct gggcgatttt gggaaaggaa attctatttc gcaaaccgct      180

gatcgtacca aatacagaag cgtgagaaga ttacgtgaac gatttttatt gaggagagaa      240

cgactacaca gagttttaca tcttttaaat tttcttccac agcattatgc ttcacaaatt      300

gattttgaaa aaaaattcgg gaagtttaaa tctgaaactg aacccaaatt ggcatgggaa      360

aattggggtg gaaagttttc attccttttc caaaactctt tcaatgaaat gcttgaagat      420

tttaaagcag ctggacaggg tttaaaaatt ccttacgact ggacaattta ttatctccgt      480

aaaaaagcac tttcacaaaa aattgaaaag gaggaactgg cctggattct tttaaacttt      540

aatcagaaac gaggatatta tcaattgcgt ggtgaggaag aagaagagaa tcctaataag      600

ctggttgaat tttattcttt aaaaattgta gatgttgtag cagatgaacc tcaaaaagga      660

aaatctgata tttggtattc tttgatttta gagaatggat gggtttacag acgagcaagc      720

aaaatacccc tatttgactg gaaagataaa acaagagatt ttattgtaac aactgatttg      780

aatgatgaca gaagtgttaa aacagacaaa gaaggaaatg aaaaaagaag tttcagagca      840

ccaagcgaaa acgattggac attggtaaaa aagaaaaccg aacaggaaat cgaccaatct      900

cacaaaaccg ttggaaccta tatctacgaa acacttcttc taaatccgaa acaaaaaatt      960

aaaggaaaat tggttcggac gattgaaaga aaattctata aagatgagct aaaacaaatt     1020

ttagaaaaac aaaaggaatt tcatcaggaa cttaaaaatg atgatttgta taatgattgc     1080

attcgtgagt tgtacagaaa caacgaagca catcagctga ctttgagcaa gaaagatttt     1140

gttcatcttt tgatggatga tcttattttc taccaaagac ctttgagaag ccagaaatca     1200

tctatttcca actgtacgtt agagtttaga aaatataaag atgaaaatgg aatagagcat     1260

acacaatatt taaaagccat tccaaaatcc aatccgtatt atcaggaatt tcgtctttgg     1320

caatggatgt ataatctgaa tatttacaga aaggacgatg aagcgaatgt taccaaagaa     1380

tttttaaata cgaacaaaga ttttgaaagt ctgtttgaat ttttaaataa tagaaaagaa     1440

attgagcaaa agccattgat taaatttctt ttggaacaaa aagatatcaa taaaaaattg     1500

cttaacgctg aagcagaaaa atatcgctgg aactatgtag aagacaagaa atatccttgc     1560

aatgaaacca aaacgatgat ttcttctcgt ttggataaag tcgaaaacat ttctgatgat     1620

ttcctgacaa gggacattga gcagaaaatt tggcacatca tctattccgt caatgataaa     1680

atagaatatg aaaaagcttt gaaatctttt gcaactagaa acgatttgga tgaaaactct     1740

tttatcgaag cgtttaagaa attctcgcct tttaaaagtg aatatggttc tttttcggaa     1800

aaagcaatta aaaagttact gcctttaatg cgattgggta aatattggta tgaagatgaa     1860

attgtaaagc atagtgatat ttatttcaaa aatattgaga atcttttggg tgatttttca     1920

aatagagaca aaaaaatttc tgaagaagac aaagagaaat ggaataaatc tataaatcta     1980

aagttacagg aagagttaaa agattttcaa acagctgaaa tagatttatt tcaaggatta     2040

cgattgcata ttgctcaata ccttgtttat ggaagacatt cagaagcttc aatgattgga     2100

aaatggaatt ccgccgaaga tttagaagaa tttttaaagg attttaaaca gcattcgctt     2160

cgcaacccga ttgtagaaca agtgattaca gaaactttgc gtgttgtaaa agatatttgg     2220

ttgaaatacg gaaatggagc aaaggatttc ttcaatgaaa ttcatattga gttaggaaga     2280

gaaatgaaac ttcccgcaga tgatcgaaaa aaactaacga accagatttc tgaaaacgaa     2340

aataccaatt tccgcatcaa agctctattg gctgaaatga tgaatgacag ttcggtagaa     2400

aatgtccgtc cgttttcgcc gatgcagcaa gaaattttaa aaatttatga agacgatgtt     2460

ttaaaatcag atatagaaat tgaagatgat attctgaaaa tcagcaaaac cgctcaacct     2520

tctccttccg atttgaaacg atataaactt tggttggaac agaaatacaa atcgccttac     2580

acggggcaaa ttattccttt gaataaattg tttacaccag aatacgaaat tgagcacatt     2640

attccgcaga gccgatattt tgatgacagt tttagcaata aagtaatttg tgagtctgcg     2700

gttaataaat tgaaagataa ctacatcgga cttgaattta ttaagcagtt cggaggaacg     2760

attattgaac ttggttttgg taaaagcata aaagtttttg aaacaaaaga atacgaagat     2820

ttcgtcaaaa aacattacgc caacaatcaa ggtaaaagaa acaaactttt gatggaagat     2880

attccagaga aaatgattga acgtcaaatg aacgatacac gatatatcag caaatatatt     2940

tcgggcgttt tgtctaatat tgttcgggta gaagatggtt cagatgaagg ggtaaattct     3000

aaaaatattg ttcccggaaa cggaaaaatc accacacagc tgaaacaaga ttggggattg     3060

aatgatgttt ggaatgattt gattttacca cgctttgaaa gaatgaacca actcaccaat     3120

tcaaaagttt ttactgcctg gaatgagaat tatcaaaagt ttttaccaac tgttcctatt     3180

gaatattcca aagggttttc aaagaaaaga atagaccacc gccatcacgc tttagatgct     3240

ttggtgattg cctgtgctac aaaagatcac gtgaatttat taaataatca atcggcaaaa     3300

tcggatacca aacgatacga tttgaaaaag aaatcgatga agtttgaaaa agtagtttac     3360

aatgatgcca aaacaggaga gaaaatcgaa agggaagtgc caaaacaatt tttaaaacct     3420

tgggaaaatt ttacgctaga tgttaaacat aatttggaaa ctattattgt aagttttaag     3480

caaaatcttc gtgttattaa taaagcgact aattattacg aaaagtatgt tgagaaagac     3540

ggtacaaaaa ataaggaaag agtagagcag accggaacaa actgggcgat taggaaacca     3600

atgcataaag acacggtttc cggtaaagta gatttacctt gggtaaaagt cccaaaaggg     3660

aaaattttaa cagcaacaag gaaaagcctt gatagttcgt ttgacttaaa gtcaataggc     3720

tctattacgg atacaggaat tcagaaaata ctcaaaaatt atttagcatt taaagacgga     3780

aatcctgaac tggctttttc accagaagga attgacgatt tgaataaaaa tattgaaaaa     3840

tacaatgatg gaaaaccgca tcaacccatc aataaagtaa gggtttttga attgggaagt     3900

aaatttcagg taggacaaag tggaaataaa aaagataaat atgtagaagc tgcaaaagga     3960

actaatctat tctttgctgt ttatgaagat gaaaaaggaa agagaaatta tgaaaccatt     4020

cctttgaatg aagtgattga aaggcaaaag caaggtttat ctgtggttga tttaaaaggt     4080

acaaatgatt tctacttatg tccgaatgat tttgtatata ttccatcagg cgacgaactt     4140

gaaaatataa ataatgttga ttttaaagac attaaaaaag agataaacga aagaatttac     4200

aaagtagtaa gttttacagg taatagactt tcctgtattc catatatggt tgcaacaacg     4260

attgttaata aattagagtt tacgcaactt aataaaattg aattcacaaa agaaaaagaa     4320

atttgtataa aactaaatgt cgatcgttta ggtaacattt caaaagcg                  4368


<210> 196
<211> 4368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="APG01688.1 E. coli optimized"

<400> 196
atgatgatta aaaatatcct aggcctggac ctgggaacca acagcatcgg ctgggcgctg       60

attaaacagg acttcgaaaa taagcatggc gagatactag gcatgggcag ccgaataatc      120

ccgatgagtc aggacatact aggcgacttc ggcaagggca acagcatcag ccagaccgcg      180

gaccgcacaa aatatcgcag cgtgcgtaga ctgcgcgaac gctttctgtt acgtcgtgaa      240

cgtctgcatc gtgttcttca cctattaaac ttcctgccgc agcattacgc tagccagatc      300

gacttcgaga agaagttcgg caagttcaag agcgagaccg aaccaaaact ggcgtgggaa      360

aactggggcg gcaaattcag cttcctattc caaaatagct tcaacgagat gctagaggac      420

ttcaaggcgg cgggtcaggg attaaaaata ccgtacgact ggaccatata ctacctgcgc      480

aagaaagcgc tgagccagaa gatcgagaag gaggagctgg cgtggatact actgaacttt      540

aatcaaaagc gcggatacta ccagctgcgc ggcgaggagg aggaggagaa cccgaataaa      600

ctggtggagt tctacagcct gaaaatagtg gacgtggtgg cggacgagcc gcagaaaggc      660

aaaagcgaca tctggtactc actcatacta gaaaacggct gggtgtatcg ccgcgcgagc      720

aaaataccgc tgttcgactg gaaagataaa acccgcgact tcatcgtgac caccgacctg      780

aacgacgacc gcagcgtgaa aaccgacaaa gaaggcaatg aaaaacgcag ctttcgcgcg      840

ccgagcgaaa acgattggac cctggtgaaa aagaaaaccg aacaggaaat cgatcagagc      900

cataaaaccg tgggcacata tatctatgaa accctgttat taaacccgaa gcagaagatt      960

aaaggcaaac tggtgcgcac catcgaacgc aaattctaca aagacgaatt aaaacagata     1020

ctagaaaaac agaaagaatt ccaccaggaa ttaaagaacg acgacttata taacgattgc     1080

atccgcgaac tgtaccgcaa taatgaagcg caccaattaa ccctgagcaa aaaggatttc     1140

gtgcacttat taatggatga tctgatcttc taccagcgcc cgctgcgcag ccagaaatca     1200

agcatcagca attgcaccct ggaattccgc aaatacaaag atgaaaacgg catcgaacac     1260

acccagtacc tgaaagcgat cccgaaatca aacccatact accaggaatt ccgcctgtgg     1320

cagtggatgt acaacctgaa catctaccgc aaagatgatg aagcgaacgt aaccaaagaa     1380

ttcctgaaca ccaataaaga tttcgaaagc ctgttcgaat tcctgaataa tcgcaaagaa     1440

atcgaacaga aaccattaat caaattcctg ctggaacaga aagatattaa taaaaagtta     1500

ttaaacgcgg aagcggaaaa atacagatgg aactacgtgg aagataaaaa gtacccgtgc     1560

aatgaaacca aaaccatgat cagcagccgc ctggataaag tggaaaatat cagcgatgat     1620

ttcctgaccc gcgatatcga acagaaaata tggcatataa tctacagcgt gaacgataaa     1680

atcgaatatg aaaaagcatt aaaatcgttc gcgacccgca acgatctgga tgaaaatagc     1740

ttcatcgaag cattcaaaaa gttcagcccg ttcaaaagcg aatacggcag cttcagcgaa     1800

aaagcgatta aaaagctgct gccattaatg cgcctgggaa aatactggta cgaagatgaa     1860

atcgtgaaac acagcgatat ctacttcaaa aacatcgaaa acctgctggg cgatttcagc     1920

aaccgcgata aaaagatcag cgaagaagat aaagaaaaat ggaacaaaag catcaacctg     1980

aaactgcagg aagaactgaa agatttccag accgcggaaa tcgatctgtt ccagggcctg     2040

cgcctgcata tcgcgcagta cctggtgtac ggccgccata gcgaagcgag catgatcggc     2100

aaatggaact cagcggaaga tctggaagaa ttcctgaaag atttcaaaca gcatagcctg     2160

cgcaacccga tcgtggaaca ggtgatcacc gaaaccctgc gcgtggtgaa agatatctgg     2220

ctgaaatatg gcaacggcgc gaaagatttc tttaacgaaa ttcatatcga actgggccgc     2280

gaaatgaaac tgccggcgga tgatcgcaaa aagctgacca accagatcag cgaaaacgaa     2340

aacaccaact ttcgcatcaa agcgctgctg gcggaaatga tgaacgatag cagcgtggaa     2400

aacgtgcgcc cgtttagccc gatgcagcag gaaatcctga aaatctatga agatgatgtg     2460

ctgaaaagcg atatcgaaat cgaagatgat atcttaaaaa tcagcaaaac cgcgcagccg     2520

agcccgagcg atctgaaacg ctataaactg tggctggaac agaaatataa aagcccgtat     2580

accggccaga tcatcccgct gaacaaactg tttaccccgg aatatgaaat cgaacatatc     2640

atcccgcaga gccgctattt tgatgatagc tttagcaaca aagtgatctg cgaaagcgcg     2700

gtgaacaaac tgaaagataa ctatatcggc ctggaattca tcaaacagtt tggcggcacc     2760

atcatcgaac tgggctttgg caaaagcatc aaagtgtttg aaaccaaaga atatgaagat     2820

tttgtgaaaa agcattatgc gaacaaccag ggcaaacgca acaaactgtt aatggaagat     2880

atcccggaga aaatgatcga acgccagatg aacgataccc gctatatcag caaatatatc     2940

agcggcgtgc tgagcaacat cgtgcgcgtg gaagatggca gcgatgaagg cgtgaacagc     3000

aaaaacatcg tgccgggcaa cggcaaaatc accacccagc tgaaacagga ttggggcctg     3060

aacgatgtgt ggaacgatct gatcctgccg cgctttgaac gcatgaacca gctgaccaac     3120

agcaaagtgt ttaccgcgtg gaacgaaaac tatcagaaat ttctgccgac cgtgccgatt     3180

gaatatagca aaggctttag caaaaagcgc attgatcatc gccatcatgc gctggatgcg     3240

ttagtgattg cgtgcgcgac caaagatcat gtgaacctgc tgaacaacca gagcgcgaaa     3300

agcgatacca aacgctatga tctgaaaaag aaaagcatga aatttgaaaa agtggtgtat     3360

aacgatgcga aaaccggcga gaaaattgaa cgcgaagtgc cgaaacagtt tctgaaaccg     3420

tgggaaaact ttaccctgga tgtgaaacat aacctggaaa ccattattgt gagctttaaa     3480

cagaacctgc gcgtgattaa caaagcgacc aactattatg aaaaatatgt ggaaaaagat     3540

ggcaccaaaa acaaagaacg cgtggaacag accggcacca actgggcgat tcgcaaaccg     3600

atgcataaag ataccgtgtc aggcaaagtg gatctgccgt gggtgaaagt gccgaaaggc     3660

aaaattctga ccgcgacccg caaaagcctg gatagcagct ttgatctgaa aagcattggc     3720

agcattaccg ataccggcat tcagaaaatt ctgaaaaact atctggcgtt taaagatggc     3780

aacccggaac tggcgtttag cccggaaggc attgatgatc tgaacaaaaa cattgaaaaa     3840

tataacgatg gcaaaccgca tcagccgatt aacaaagtgc gcgtgtttga actgggcagc     3900

aaatttcagg tgggccagag cggcaacaaa aaggacaaat atgtggaagc ggcgaaaggc     3960

accaacctgt tctttgcggt gtatgaagat gaaaaaggca aacgcaacta tgaaaccatc     4020

ccgttaaacg aagtgattga acgccagaaa cagggcctga gcgtggtgga tctgaaaggc     4080

accaacgatt tttatctgtg cccgaacgat tttgtgtata ttccgagcgg cgatgaactg     4140

gaaaacatta acaacgtgga ttttaaagat attaaaaagg aaattaacga acgcatctat     4200

aaagtggtga gctttaccgg caaccgcctg agctgcattc cgtatatggt ggcgaccacc     4260

attgtgaaca aactggaatt cacccagctg aacaaaattg aattcaccaa agaaaaagaa     4320

atttgcatta aactgaacgt ggatcgcctg ggcaacatta gcaaagcg                  4368


<210> 197
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Ataxia-telangiectasia syndrome"

<400> 197
gaattattcc agaaagccaa agtag                                             25


<210> 198
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Very long chain acyl-CoA 
      dehydrogenase deficiency"

<400> 198
ggcttcatga aggtacagga                                                   20


<210> 199
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Abnormality of T cell physiology"

<400> 199
ggtgtgctca ccagaatgga gtaca                                             25


<210> 200
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 200
gcagatcatt ggggtggatc ccgaa                                             25


<210> 201
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for 3-Oxo-5 alpha-steroid delta 
      4-dehydrogenase deficiency"

<400> 201
ggctgcaagc ttttcaccac cayag                                             25


<210> 202
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Acute myeloid leukemia"

<400> 202
gggcggcatg aaccggaggc ccatc                                             25


<210> 203
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Acute myeloid leukemia"

<400> 203
gcatgggcgg catgaaccgg                                                   20


<210> 204
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cutaneous malignant melanoma 3"

<400> 204
gtggccactg tggggatcac                                                   20


<210> 205
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Alpha-1-antitrypsin deficiency"

<400> 205
gtgctgacca tcgacgagaa                                                   20


<210> 206
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease, type 2"

<400> 206
ggcgagctgc atgatctgcg                                                   20


<210> 207
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 207
gcacatgacg gaggttgtga ggcgc                                             25


<210> 208
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 208
gaggttgtga ggcactgccc ccacc                                             25


<210> 209
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 209
gcagcatccg gctgcaggta                                                   20


<210> 210
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Brugada syndrome"

<400> 210
ggccaagggg atccgcacgc tgctc                                             25


<210> 211
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Brugada syndrome"

<400> 211
gcctgatgac gcaggactgc                                                   20


<210> 212
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for GRACILE syndrome"

<400> 212
ggtacgaagt ctcgacactg                                                   20


<210> 213
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Enhanced s-cone syndrome"

<400> 213
ggcattggcg gtggacccca                                                   20


<210> 214
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease, type 2"

<400> 214
gaagaacagg ttctggacgt caaag                                             25


<210> 215
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease, type 2"

<400> 215
gaacaggttc tggacgtcaa                                                   20


<210> 216
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Arylsulfatase a, allele a"

<400> 216
gacaggtcat agagcagcgg                                                   20


<210> 217
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 217
gaacgtggtc gctctggaca                                                   20


<210> 218
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 218
gaacgtggtc gctctggaca                                                   20


<210> 219
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for HEMOGLOBIN ARLINGTON PARK"

<400> 219
ggtgcatctg actcctgagg agaag                                             25


<210> 220
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypertrophic cardiomyopathy 1"

<400> 220
gaagtccgag gctcgccgca                                                   20


<210> 221
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 221
gtcaaggtca tcggtgaggc                                                   20


<210> 222
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 222
ggtcatcagt gaggccggcc ggggt                                             25


<210> 223
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Brugada syndrome"

<400> 223
gtctcagcct tacgcacctt ccgag                                             25


<210> 224
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Brugada syndrome"

<400> 224
gcaccttcca agtcctccgg gccct                                             25


<210> 225
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 225
gaagccagcc cctcagggca actgac                                            26


<210> 226
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deficiency of butyryl-CoA dehydrogenase"

<400> 226
ggcgactcat gggttctgaa                                                   20


<210> 227
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deficiency of butyryl-CoA dehydrogenase"

<400> 227
gcgactcacg ggttctgaat ggaac                                             25


<210> 228
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Benign scapuloperoneal muscular 
      dystrophy with cardiomyopathy"

<400> 228
ggaactgcgg gcccagcatg                                                   20


<210> 229
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Benign scapuloperoneal muscular 
      dystrophy with cardiomyopathy"

<400> 229
ggacgagtac caggagcttc                                                   20


<210> 230
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cone-rod dystrophy 6"

<400> 230
ggatctgatc cgggagcgca                                                   20


<210> 231
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cone-rod dystrophy 6"

<400> 231
gaatgcacta tgttctattc catcc                                             25


<210> 232
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Stargardt disease 1"

<400> 232
gagctgctca caggacgaga acatc                                             25


<210> 233
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Leber congenital amaurosis 2"

<400> 233
gtctatccag taagtatctc                                                   20


<210> 234
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cone-rod dystrophy 3"

<400> 234
ggtacgtcca tgccacaccc                                                   20


<210> 235
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Nonsyndromic Oculocutaneous Albinism"

<400> 235
ggacctttac ggcgtaatcc                                                   20


<210> 236
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Phenylketonuria"

<400> 236
gtcatccttt ggtgaattac                                                   20


<210> 237
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Phenylketonuria"

<400> 237
gtattacgtg gcagagagtt ttaat                                             25


<210> 238
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 238
ggacgctctt gtattatctg                                                   20


<210> 239
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hyperphenylalaninemia, non-pku"

<400> 239
gcccttctca gttcgctacg accca                                             25


<210> 240
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hyperphenylalaninemia, non-pku"

<400> 240
gctacgaccc atacacccaa                                                   20


<210> 241
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 241
gcgctatgtt ctattccatc                                                   20


<210> 242
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 242
ggggctggta ttcatgaaag gcaac                                             25


<210> 243
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 243
gcgctatgtt ctattccatc                                                   20


<210> 244
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 244
gtgttctcag gttatcggta agttt                                             25


<210> 245
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 245
ggaaatgctg ttagtcggta tgtcg                                             25


<210> 246
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 246
ggaaatgctg ttagtcagta tgtcg                                             25


<210> 247
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Anterior segment dysgenesis 6"

<400> 247
gtggccactg atcggaaacg                                                   20


<210> 248
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Brugada syndrome"

<400> 248
gaacctgatc ctggccgtgg tcgca                                             25


<210> 249
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Brugada syndrome"

<400> 249
gatcctggcc gtggtcgcaa                                                   20


<210> 250
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Ornithine carbamoyltransferase 
      deficiency"

<400> 250
gaagggccat gaccttctca ctcta                                             25


<210> 251
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Osteogenesis imperfecta type I"

<400> 251
ggtgctcgag gattgcccgg aacag                                             25


<210> 252
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Osteogenesis imperfecta type I"

<400> 252
gctcgaggat tgcccggaac agctg                                             25


<210> 253
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Constipation"

<400> 253
gattccagtt aaatggatgg caatt                                             25


<210> 254
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Dopamine beta hydroxylase deficiency"

<400> 254
ggacactgcc tattttgcgg tgagt                                             25


<210> 255
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cystic fibrosis"

<400> 255
gacttcatcc aggtatgtaa aaata                                             25


<210> 256
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Phenylketonuria"

<400> 256
gatgtaaacc tgacccacac tgaat                                             25


<210> 257
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deficiency of 
      UDPglucose-hexose-1-phosphate uridylyltransferase"

<400> 257
gagcccctga cacccttacc                                                   20


<210> 258
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Amyloid Cardiomyopathy, 
      Transthyretin-related"

<400> 258
gtcaccaatc ccaaggaatg                                                   20


<210> 259
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Carbohydrate-deficient 
      glycoprotein syndrome type I"

<400> 259
ggctactcca tgacagcgcc tgagg                                             25


<210> 260
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Metachromatic leukodystrophy"

<400> 260
gcatcccgta ctcccacgac cagat                                             25


<210> 261
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Smith-Lemli-Opitz syndrome"

<400> 261
gttcttcaat gggcgccccg ggatc                                             25


<210> 262
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deafness, autosomal recessive 1A"

<400> 262
gcaggtgagc ccgccggccc                                                   20


<210> 263
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital omphalocele"

<400> 263
gccagcgctc ctagtggcca tgcac                                             25


<210> 264
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital omphalocele"

<400> 264
gcgctcctag tggccatgca cgtgg                                             25


<210> 265
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital omphalocele"

<400> 265
gtccacgcca gcgctcctag                                                   20


<210> 266
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital omphalocele"

<400> 266
gctcctagtg gccatgcacg                                                   20


<210> 267
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital myotonia, autosomal 
      dominant form"

<400> 267
gagaggattc tttgcagcca cgttc                                             25


<210> 268
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 268
ggtgacccga gagtgggtgt                                                   20


<210> 269
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast and/or ovarian cancer"

<400> 269
gatgcctgga cagaggacaa                                                   20


<210> 270
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 270
ggacaatggc ttccatggta                                                   20


<210> 271
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 271
gggctagaaa tctgttgcta                                                   20


<210> 272
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 272
ggtgacccga gagtgggtgt                                                   20


<210> 273
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 273
gattctgcaa ctttcaattg                                                   20


<210> 274
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 274
ggacaatggc ttccatggta                                                   20


<210> 275
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 275
gaaagcccga cttatagcca gtaat                                             25


<210> 276
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 276
gattacatga acaaatgggc                                                   20


<210> 277
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 277
gattacatga acaaatgggc                                                   20


<210> 278
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 278
gactggaaaa ggaatacagt                                                   20


<210> 279
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast and/or ovarian cancer"

<400> 279
gttggctgat ggtggatggc tcata                                             25


<210> 280
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 280
gttggctgat ggtggatggc tcata                                             25


<210> 281
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 281
ggtcagaaga ttattcttca                                                   20


<210> 282
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 282
ggcttctagt ctcttttgtt                                                   20


<210> 283
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 283
ggcttctagt ctcttttgtt                                                   20


<210> 284
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Smith-Lemli-Opitz syndrome"

<400> 284
gttgcgattt tgcagccatt                                                   20


<210> 285
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Alport syndrome 1, X-linked recessive"

<400> 285
ggcctatggg tccccctggt ttcgg                                             25


<210> 286
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Acute neuronopathic Gaucher's disease"

<400> 286
ggcatcaggt gagtgagtca                                                   20


<210> 287
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Gonadotropin deficiency"

<400> 287
gtaactctcc agcataccat                                                   20


<210> 288
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Distal arthrogryposis type 1A"

<400> 288
gaagctggag gaggccgaga                                                   20


<210> 289
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Distal arthrogryposis type 1A"

<400> 289
gctggaggag gccgagaagg                                                   20


<210> 290
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing syndrome"

<400> 290
gctgccacct tcagggcctc                                                   20


<210> 291
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 291
gataaacttc ttgaagagga                                                   20


<210> 292
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Death in early adulthood"

<400> 292
gtgttctcca tgttcgaaca gaccc                                             25


<210> 293
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Death in early adulthood"

<400> 293
gttcgaacag acccaaatcc                                                   20


<210> 294
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Severe autosomal recessive muscular 
      dystrophy of childhood - North African type"

<400> 294
gaaatctgtg tgtgtccaga                                                   20


<210> 295
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 295
ggtcatcatt gagagcgacc                                                   20


<210> 296
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Carbohydrate-deficient glycoprotein 
      syndrome type I"

<400> 296
gaatgctgaa gatgatcgac                                                   20


<210> 297
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease, type I"

<400> 297
gaatgctgaa gatgatcgac                                                   20


<210> 298
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 298
gctcagtaca ccaccgtcgg ccgca                                             25


<210> 299
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 299
gtacaccacc gtcggccgca                                                   20


<210> 300
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial Mediterranean fever"

<400> 300
ggacacgtga tggagggaag aacac                                             25


<210> 301
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deafness, autosomal recessive 2"

<400> 301
ggacctttgt caatgggaca cggac                                             25


<210> 302
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deafness, autosomal recessive 2"

<400> 302
ggacctttgt caatgggaca cagac                                             25


<210> 303
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deafness, X-linked 2"

<400> 303
gcgctcctag tggccatgca cgtgg                                             25


<210> 304
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Enlarged vestibular aqueduct"

<400> 304
gccaccactg ctctttcccg cacgg                                             25


<210> 305
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital sensorineural 
      hearing impairment"

<400> 305
gtggtcatta acacaaactc                                                   20


<210> 306
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deficiency of 
      UDPglucose-hexose-1-phosphate uridylyltransferase"

<400> 306
gccagatatt gcccagcgtg                                                   20


<210> 307
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Very long chain acyl-CoA 
      dehydrogenase deficiency"

<400> 307
gccactaatc gtacccagtt                                                   20


<210> 308
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 308
gatattccac tggtggtcga                                                   20


<210> 309
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Pyruvate kinase deficiency of red cells"

<400> 309
ggaagactcc tgggcataag                                                   20


<210> 310
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Autosomal dominant progressive 
      external ophthalmoplegia with mitochondrial DNA 
      deletions 1"

<400> 310
gaagtcgttg atggatctgg ccaat                                             25


<210> 311
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Very long chain acyl-CoA 
      dehydrogenase deficiency"

<400> 311
gaagatcaca gcttttgtgg                                                   20


<210> 312
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cystinosis, ocular nonnephropathic"

<400> 312
gtccatctcc ttctaccctc                                                   20


<210> 313
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Pyruvate kinase deficiency of red 
      cells"

<400> 313
gctcagccca gcttctgtct                                                   20


<210> 314
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Distal myopathy, Tateyama type"

<400> 314
gattgacctg gtgaaccaag acccc                                             25


<210> 315
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Malignant hyperthermia, 
      susceptibility to, 1"

<400> 315
ggccctgcgg atccgcgcca tcctc                                             25


<210> 316
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Malignant hyperthermia, 
      susceptibility to, 1"

<400> 316
ggatccgcgc catcctccgc tccct                                             25


<210> 317
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Myopathy, Central Core"

<400> 317
ggtctgatca tcgacgcttt tggtg                                             25


<210> 318
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Myopathy, Central Core"

<400> 318
ggtctgatca tcgacgcttt                                                   20


<210> 319
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Myopathy, Central Core"

<400> 319
gatcatcgac acttttggtg agctc                                             25


<210> 320
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Malignant hyperthermia, 
      susceptibility to, 1"

<400> 320
ggcggaggca ttggggacga gatcg                                             25


<210> 321
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Ceroid lipofuscinosis neuronal 2"

<400> 321
gtgacagtgg ggccgggtgt                                                   20


<210> 322
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Ceroid lipofuscinosis neuronal 2"

<400> 322
ggggccgggt attggtctgt ctctg                                             25


<210> 323
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Niemann-Pick disease type C1"

<400> 323
ggatcgacga ttatttcgac tgggt                                             25


<210> 324
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Glutaric aciduria, type 1"

<400> 324
gagtatcacg tgatccggca cgcca                                             25


<210> 325
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for CAPN3-Related Disorders"

<400> 325
gccctgatgc agaagaaccg gcgga                                             25


<210> 326
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for CAPN3-Related Disorders"

<400> 326
gatgcagaag aaccggcgga                                                   20


<210> 327
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Glycogen storage disease, type II"

<400> 327
gtcccagaac agctcccctc                                                   20


<210> 328
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Nonsyndromic Oculocutaneous Albinism"

<400> 328
gtacagggat ctgccaacga tccta                                             25


<210> 329
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 329
gcgaagatgg ctcggatgag                                                   20


<210> 330
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 330
gagtggccgc agcgctgtag                                                   20


<210> 331
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Deafness, autosomal recessive 7"

<400> 331
ggtctcaagc tctctcttcg                                                   20


<210> 332
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Chronic infantile neurological, 
      cutaneous and articular syndrome"

<400> 332
gacggcttcg atgagctgca                                                   20


<210> 333
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Eichsfeld type congenital  
      muscular dystrophy"

<400> 333
gactctccgg gagactgtcc                                                   20


<210> 334
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 334
gctcaaaagt ggatgagcgc                                                   20


<210> 335
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hyperkalemic Periodic Paralysis  
      Type 1"

<400> 335
gcagctgcgg gtcttcaagc                                                   20


<210> 336
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inclusion body myopathy 2"

<400> 336
ggacgtggat gtggtggttt                                                   20


<210> 337
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Severe APG05083.1, APG07433.1, 
      APG07513.1, APG08290.1 immunodeficiency due to ADA  
      Deficiency"

<400> 337
gaagagcggc attcaccgta ctgtc                                             25


<210> 338
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Severe APG05083.1, APG07433.1, 
      APG07513.1, APG08290.1 immunodeficiency due to ADA  
      Deficiency"

<400> 338
gcggtacagt ccgcacctgc tggcc                                             25


<210> 339
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 339
gtgtccgagc agcgccactg                                                   20


<210> 340
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cystic fibrosis"

<400> 340
ggacacttcg tgccttcgga                                                   20


<210> 341
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cystic fibrosis"

<400> 341
ggacacttcg tgccttcgga                                                   20


<210> 342
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Adrenocortical carcinoma, pediatric"

<400> 342
gggcgtgagc acttcgagat gttcc                                             25


<210> 343
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Fumarase deficiency"

<400> 343
gattggacgt actcatactc                                                   20


<210> 344
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Adenocarcinoma of prostate"

<400> 344
gaacactgtc cattggcatg                                                   20


<210> 345
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypertrophic cardiomyopathy 1"

<400> 345
gcatcctcta cggggacttc                                                   20


<210> 346
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Adult hypophosphatasia"

<400> 346
gacaacgaga tgccccctga ggcct                                             25


<210> 347
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Adult hypophosphatasia"

<400> 347
ggtactcaga caacaagatg ccccc                                             25


<210> 348
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Adult hypophosphatasia"

<400> 348
gacaacaaga tgccccctga ggcct                                             25


<210> 349
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 349
gccttcttgg acaacgtcac cacca                                             25


<210> 350
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inborn genetic diseases"

<400> 350
ggtttgccat ccgaggggta gtgct                                             25


<210> 351
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Crouzon syndrome"

<400> 351
gcaaatgcct ccacagtggt                                                   20


<210> 352
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Propionyl-CoA carboxylase deficiency"

<400> 352
gacatcatag gcacctccat                                                   20


<210> 353
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 353
ggtggaaggg atcggctacg acttc                                             25


<210> 354
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Dysostosis multiplex"

<400> 354
ggagcagctc tgggccgaag tgtcg                                             25


<210> 355
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Multiple sulfatase deficiency"

<400> 355
ggcgactcct ttgtctttga                                                   20


<210> 356
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Bifunctional peroxisomal enzyme  
      deficiency"

<400> 356
ggtggtactg gtcaccggcg                                                   20


<210> 357
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Bifunctional peroxisomal enzyme  
      deficiency"

<400> 357
gtactggtca ccagcgcggg ggcag                                             25


<210> 358
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing  
      syndrome"

<400> 358
ggaaacttgt aagggcttcg                                                   20


<210> 359
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 359
gtgcagacat tgacgaatgc cgcat                                             25


<210> 360
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 360
gacattgacg aatgccgcat atctc                                             25


<210> 361
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Limb-girdle muscular dystrophy, 
      type 2L"

<400> 361
gcatagtagt aaactagacg                                                   20


<210> 362
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 362
gcatcgatgt caacgagggc aaccg                                             25


<210> 363
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Spastic Paraplegia, Recessive"

<400> 363
gcactgctgc tcggcccccc                                                   20


<210> 364
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Isovaleryl-CoA dehydrogenase  
      deficiency"

<400> 364
ggagcagtgg ggctcagtta                                                   20


<210> 365
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 365
gaggagctgc ctcacaggtg                                                   20


<210> 366
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Biotinidase deficiency"

<400> 366
gctccagcgc ctgagttgta                                                   20


<210> 367
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Biotinidase deficiency"

<400> 367
gcctgagttg tatggccatc                                                   20


<210> 368
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Leber congenital amaurosis"

<400> 368
gcataatttg tacagctcta agagt                                             25


<210> 369
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hyperinsulinism"

<400> 369
ggtggctgag cccagcccgg ccccc                                             25


<210> 370
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial cancer of breast"

<400> 370
ggatgcttgg cagtgggaaa aactt                                             25


<210> 371
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cohen syndrome"

<400> 371
ggaggtctac tacaggtctg                                                   20


<210> 372
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 372
gctccctctg tactgtgcag gagtc                                             25


<210> 373
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Wilson disease"

<400> 373
ggcaatgaac acaaagagca                                                   20


<210> 374
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Wilson disease"

<400> 374
gccctggatg ggctcagcgg ccatg                                             25


<210> 375
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Wilson disease"

<400> 375
gcagccctgg atgggctcag                                                   20


<210> 376
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 376
gtggcccagc gaagatgcga                                                   20


<210> 377
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 377
gaagatgcga aggtgatttc                                                   20


<210> 378
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Floating-Harbor syndrome"

<400> 378
gctgaagctg gagtgggtcg                                                   20


<210> 379
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital long QT syndrome"

<400> 379
gatgctacac gtcgaccgcc aggga                                             25


<210> 380
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Congenital long QT syndrome"

<400> 380
gatgctacac gtcgaccgcc                                                   20


<210> 381
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Andersen Tawil syndrome"

<400> 381
gaggaagaga tcaaggtcct ttcca                                             25


<210> 382
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 382
gagctgataa ccaccctgta catcg                                             25


<210> 383
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 383
ggaaaactgc ggtatgggcg                                                   20


<210> 384
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 384
gtatttgaag gtctcctccg gggtc                                             25


<210> 385
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Gastrointestinal stroma tumor"

<400> 385
gagggctaaa gtgggctcgg                                                   20


<210> 386
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Dyskeratosis congenita"

<400> 386
gctgccaagc ctgctggcaa                                                   20


<210> 387
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Dyskeratosis congenita"

<400> 387
gccctgcctg tgacttccag cactg                                             25


<210> 388
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Glycogen storage disease IIIa"

<400> 388
gatgagtaga acagaaaaat acaag                                             25


<210> 389
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Dilated cardiomyopathy 1DD"

<400> 389
gtctcgtagt ccggtgagcc ggtca                                             25


<210> 390
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Renal carnitine transport defect"

<400> 390
gtggccatgg aatagcgccg                                                   20


<210> 391
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Baraitser-Winter syndrome 1"

<400> 391
gatcctcacc gagcgcggct acagc                                             25


<210> 392
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Very long chain acyl-CoA  
      dehydrogenase deficiency"

<400> 392
gggcatgcat gaccttggcg tgggc                                             25


<210> 393
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 393
gtcagatttg tccttgcagt                                                   20


<210> 394
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Limb-girdle muscular dystrophy, 
      type 2A"

<400> 394
gtacggggtt gctctgccgg                                                   20


<210> 395
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 395
gacagtagcc cctgctcggc cttcg                                             25


<210> 396
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Aortic aneurysm, familial thoracic 6"

<400> 396
gccccatgcc atcatgcgtc                                                   20


<210> 397
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Acromicric dysplasia"

<400> 397
gctttgtcat cgacatttat accgg                                             25


<210> 398
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease type 2C"

<400> 398
ggcggacatg cggcaccagg actcg                                             25


<210> 399
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 399
gtgtaactgt atacgtatgg cgttt                                             25


<210> 400
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 1"

<400> 400
gatgcctgga cagaggacaa                                                   20


<210> 401
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease type 2C"

<400> 401
gcctaactga tgaggagttt cgagg                                             25


<210> 402
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Charcot-Marie-Tooth disease type 2C"

<400> 402
gcctaactga tgaggagttt caagg                                             25


<210> 403
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing  
      syndrome"

<400> 403
gagcgctgct cagatagcga                                                   20


<210> 404
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Early infantile epileptic  
      encephalopathy"

<400> 404
gatgatccgc atggaccggc gggga                                             25


<210> 405
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Early infantile epileptic  
      encephalopathy"

<400> 405
ggatgatccg catggaccgg                                                   20


<210> 406
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Early infantile epileptic  
      encephalopathy"

<400> 406
gcggatgatc cgcatggacc agcgg                                             25


<210> 407
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Acromicric dysplasia"

<400> 407
gtacgtgatc catcctaggt                                                   20


<210> 408
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hypertrophic cardiomyopathy"

<400> 408
gacaccacgg tctccctcaa gtggc                                             25


<210> 409
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 409
gctgtccggg gtagccccaa gatag                                             25


<210> 410
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 410
gtccacggtg agggggccct ggtgt                                             25


<210> 411
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Cardiovascular phenotype"

<400> 411
gcctagactg caggacacag ggact                                             25


<210> 412
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypertrophic  
      cardiomyopathy 1"

<400> 412
gcatctgcag acatagagac ctgtg                                             25


<210> 413
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Benign scapuloperoneal muscular  
      dystrophy with cardiomyopathy"

<400> 413
gccctccaag agcttgcggt                                                   20


<210> 414
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Glycogen storage disease, type II"

<400> 414
ggccctcacc ctgcgctacg cactc                                             25


<210> 415
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Diffuse mesangial sclerosis"

<400> 415
gtttaggcac ttgttttacc tgtat                                             25


<210> 416
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Colobomatous microphthalmia"

<400> 416
gggtcgaggc ggacgccata                                                   20


<210> 417
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Ataxia-telangiectasia syndrome"

<400> 417
gtaaatacat atttactact                                                   20


<210> 418
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial cancer of breast"

<400> 418
ggctacagca cacagctcgt                                                   20


<210> 419
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Limb-girdle muscular dystrophy, 
      type 2A"

<400> 419
gctacgagat gcaaaatgca gtcaa                                             25


<210> 420
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing  
      syndrome"

<400> 420
gccgcttacc aaaaggagta                                                   20


<210> 421
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Asymmetric septal hypertrophy"

<400> 421
gtgctgcagg ttgttggtgc atggc                                             25


<210> 422
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing  
      syndrome"

<400> 422
gtaattctat aactccttag                                                   20


<210> 423
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypertrophic  
      cardiomyopathy 2"

<400> 423
gctaaagtca ccgggcgctg gaaat                                             25


<210> 424
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypertrophic  
      cardiomyopathy 2"

<400> 424
ggctaaagtc accgggcgct agaaa                                             25


<210> 425
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypertrophic  
      cardiomyopathy 2"

<400> 425
gctaaagtca ccgggcgcta gaaat                                             25


<210> 426
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Erythrocytosis, familial, 2"

<400> 426
gaaagagcaa tgcctccagg ttgtc                                             25


<210> 427
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Death in infancy"

<400> 427
gtattggaat ccggagcatc cacgt                                             25


<210> 428
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Muscular Diseases"

<400> 428
gcatcttccg gatctttgag                                                   20


<210> 429
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 429
gctgcgagca tggggccctg aggct                                             25


<210> 430
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial cancer of breast"

<400> 430
ggcagcgtta cccagtccga                                                   20


<210> 431
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary cancer-predisposing  
      syndrome"

<400> 431
gtgtaggcaa cttctatagc cacag                                             25


<210> 432
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 432
ggaactcccg ccaagatcaa gaaag                                             25


<210> 433
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 433
gcggctgcca gtatctgtgc ctccc                                             25


<210> 434
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 434
gaatgatctg caggtgagcg tcgcc                                             25


<210> 435
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Inclusion body myopathy 2"

<400> 435
gtgctgtagt gcaccaatgt aatct                                             25


<210> 436
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Ataxia-telangiectasia syndrome"

<400> 436
gctttgatgt taacaatcgc                                                   20


<210> 437
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Benign familial  
      neonatal-infantile seizures"

<400> 437
gtcagttctc cgatcattcc agctg                                             25


<210> 438
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Marfan Syndrome/Loeys-Dietz  
      Syndrome/Familial Thoracic Aortic Aneurysms and  
      Dissections"

<400> 438
gtatctccat tgtctcctcg                                                   20


<210> 439
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Dilated cardiomyopathy 1G"

<400> 439
gtttcagatt cccctggccc acgtg                                             25


<210> 440
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 440
gcggtgagtc tcggtgcagg                                                   20


<210> 441
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Breast-ovarian cancer, familial 2"

<400> 441
gatacagtat taattgactg                                                   20


<210> 442
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 442
gcgagtgcat ccactccagc                                                   20


<210> 443
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 443
ggctacaagt gccagtgtga ggaag                                             25


<210> 444
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 444
gggtggctac aagtgccagc gtgag                                             25


<210> 445
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial hypercholesterolemia"

<400> 445
gtacaccagc ctcaccccca acctg                                             25


<210> 446
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Familial cancer of breast"

<400> 446
gcctgcccga tagacgagcc tcccg                                             25


<210> 447
<211> 20
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="target seq for Hereditary hemorrhagic  
      telangiectasia type 2"

<400> 447
gatccgcagc gcggtgagtc                                                   20


<210> 448
<211> 3
<212> DNA
<213> Streptococcus pyogenes

<220>
<221> source
<223> /note="SpyCas9 PAM"


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 448
ngg                                                                      3


<210> 449
<211> 5
<212> DNA
<213> Staphylococcus aureus

<220>
<221> source
<223> /note="SauCas9"


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 449
ngrrt                                                                    5


<210> 450
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="ADAT"

<400> 450
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
            20                  25                  30          


Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly 
        35                  40                  45              


Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
    50                  55                  60                  


Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
65                  70                  75                  80  


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
                85                  90                  95      


Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
            100                 105                 110         


His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr 
        115                 120                 125             


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn 
    130                 135                 140                 


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
145                 150                 155                 160 


Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln 
                165                 170                 175     


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
            180                 185                 190         


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
        195                 200                 205             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu 
    210                 215                 220                 


Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu 
225                 230                 235                 240 


Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile 
                245                 250                 255     


Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His 
            260                 265                 270         


Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr 
        275                 280                 285             


Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met 
    290                 295                 300                 


Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly 
305                 310                 315                 320 


Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu 
                325                 330                 335     


His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu 
            340                 345                 350         


Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg 
        355                 360                 365             


Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly 
    370                 375                 380                 


Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
385                 390                 395                 400 


Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415 


<210> 451
<211> 1494
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Nuc-ADAT-Linker-dAPG08290.1-Linker-SV40"

<400> 451
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
            20                  25                  30          


Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly 
        35                  40                  45              


Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
    50                  55                  60                  


Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
65                  70                  75                  80  


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
                85                  90                  95      


Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
            100                 105                 110         


His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr 
        115                 120                 125             


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn 
    130                 135                 140                 


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
145                 150                 155                 160 


Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln 
                165                 170                 175     


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
            180                 185                 190         


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
        195                 200                 205             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu 
    210                 215                 220                 


Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu 
225                 230                 235                 240 


Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile 
                245                 250                 255     


Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His 
            260                 265                 270         


Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr 
        275                 280                 285             


Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met 
    290                 295                 300                 


Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly 
305                 310                 315                 320 


Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu 
                325                 330                 335     


His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu 
            340                 345                 350         


Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg 
        355                 360                 365             


Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly 
    370                 375                 380                 


Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
385                 390                 395                 400 


Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Met 
                405                 410                 415     


Ser Glu Leu Asp Tyr Arg Ile Gly Leu Ala Ile Gly Thr Asn Ser Ile 
            420                 425                 430         


Gly Trp Gly Val Ile Glu Leu Phe Trp Asn Lys Asp Arg Glu Arg Tyr 
        435                 440                 445             


Glu Lys Val Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys Ala 
    450                 455                 460                 


Glu Ile Pro Asn Lys Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile Ala 
465                 470                 475                 480 


Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys Glu 
                485                 490                 495     


Ile Arg Asn Leu Leu Val Gln His Gly Met Ile Thr Gln Glu Glu Leu 
            500                 505                 510         


Asp Leu Leu Tyr Pro Leu Ser Lys Lys Ser Ile Asp Ile Trp Asp Ile 
        515                 520                 525             


Arg Leu Asp Gly Leu Asp Arg Leu Leu Asn His Leu Glu Trp Ala Arg 
    530                 535                 540                 


Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys 
545                 550                 555                 560 


Ser Glu Leu Lys Asp Ala Glu Thr Gly Lys Val Leu Ser Ser Ile Gln 
                565                 570                 575     


Val Asn Glu Lys Arg Leu Phe Leu Tyr Arg Thr Val Gly Glu Met Trp 
            580                 585                 590         


Ile Lys Asp Ala Glu Phe Ser Lys Tyr Asp Arg Arg Arg Asn Ser Pro 
        595                 600                 605             


Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu Ile 
    610                 615                 620                 


Val Thr Leu Phe Glu Ala Gln Arg Lys Phe Gln Ser Ser Tyr Ala Ser 
625                 630                 635                 640 


Lys Asn Leu Gln Glu Thr Tyr Leu Gln Ile Trp Ala His Gln Leu Pro 
                645                 650                 655     


Phe Ala Ser Gly Asn Ala Ile Leu Asn Lys Val Gly Tyr Cys Ser Leu 
            660                 665                 670         


Leu Lys Gly Lys Glu Arg Arg Ile Pro Lys Ala Thr Tyr Thr Phe Gln 
        675                 680                 685             


Tyr Phe Ser Ala Leu Asp Gln Val Asn Arg Thr Arg Leu Gly Pro Asp 
    690                 695                 700                 


Phe Gln Pro Phe Thr Gln Glu Gln Lys Glu Ile Ile Leu Asp Lys Met 
705                 710                 715                 720 


Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val Ser 
                725                 730                 735     


Tyr Tyr Asp Ile Arg Lys Trp Leu Glu Leu Asp Glu Thr Ile Gln Phe 
            740                 745                 750         


Lys Gly Leu Asn Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu Lys 
        755                 760                 765             


Lys Pro Phe Ile Asn Leu Lys Ala Phe Tyr Glu Ile Lys Lys Val Val 
    770                 775                 780                 


Ala Asn Tyr Ala Glu Arg Thr Asn Glu Ala Phe Ser Thr Leu Asp Tyr 
785                 790                 795                 800 


Asp Ala Ile Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp Ile 
                805                 810                 815     


Arg Ser Tyr Leu Lys Lys Ser Asn Asn Leu Ser Lys Arg Cys Tyr Asp 
            820                 825                 830         


Asp Gln Leu Ile Glu Glu Leu Phe Thr Leu Ser Tyr Thr Lys Phe Gly 
        835                 840                 845             


His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln Glu 
    850                 855                 860                 


Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Thr Thr 
865                 870                 875                 880 


Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Ile Pro Asp 
                885                 890                 895     


Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Ile Thr Gln Ala Arg Lys 
            900                 905                 910         


Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val His 
        915                 920                 925             


Ile Ala Leu Ala Arg Glu Leu Ser Lys Ser His Asp Glu Arg Lys Lys 
    930                 935                 940                 


Ile Met Thr Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala Ile 
945                 950                 955                 960 


Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp Ile 
                965                 970                 975     


Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr Ser 
            980                 985                 990         


Leu Lys Glu Ile Pro Pro Asp Thr  Phe Phe Asn Glu Leu  Lys Lys Glu 
        995                 1000                 1005             


Arg Asn  Gly Ser Pro Ile Leu  Glu Val Asp His Ile  Leu Pro Tyr 
    1010                 1015                 1020             


Ser Gln  Ser Phe Ile Asp Ser  Tyr His Asn Lys Val  Leu Val Tyr 
    1025                 1030                 1035             


Ser Asp  Glu Asn Arg Asn Lys  Gly Asn Arg Ile Pro  Tyr Thr Tyr 
    1040                 1045                 1050             


Phe Leu  Glu Thr Asn Lys Asp  Trp Glu Ala Phe Glu  Arg Tyr Val 
    1055                 1060                 1065             


Arg Ser  Asn Lys Leu Phe Ser  Lys Lys Lys Arg Glu  Tyr Leu Leu 
    1070                 1075                 1080             


Lys Lys  Thr Tyr Leu Pro Arg  Glu Ser Glu Leu Ile  Lys Glu Arg 
    1085                 1090                 1095             


His Leu  Asn Asp Thr Arg Tyr  Ala Ser Thr Phe Leu  Lys Asn Phe 
    1100                 1105                 1110             


Ile Glu  Gln Asn Leu Gln Phe  Lys Glu Val Glu Val  Asn Leu Arg 
    1115                 1120                 1125             


Lys Lys  Arg Val Gln Thr Val  Asn Gly Val Ile Thr  Ala His Leu 
    1130                 1135                 1140             


Arg Lys  Arg Trp Gly Leu Glu  Lys Asn Arg Gln Glu  Thr Tyr Leu 
    1145                 1150                 1155             


His His  Ala Met Asp Ala Ile  Ile Val Ala Cys Thr  Asp His His 
    1160                 1165                 1170             


Met Val  Thr Arg Ile Thr Glu  Tyr Tyr Gln Ile Lys  Glu Ser Asn 
    1175                 1180                 1185             


Lys Ser  Val Lys Lys Pro Tyr  Phe Pro Met Pro Trp  Glu Gly Phe 
    1190                 1195                 1200             


Arg Asp  Glu Leu Leu Ser His  Leu Ala Ser Gln Pro  Ile Ala Lys 
    1205                 1210                 1215             


Lys Ile  Ser Glu Glu Leu Lys  Ala Gly Tyr Gln Ser  Ser Asp Tyr 
    1220                 1225                 1230             


Ile Phe  Val Ser Arg Met Pro  Lys Arg Ser Val Thr  Gly Ala Ala 
    1235                 1240                 1245             


His Asp  Gln Thr Ile Arg Arg  Lys Gly Gly Ile Asp  Lys Lys Gly 
    1250                 1255                 1260             


Lys Thr  Ile Ile Ile Lys Arg  Val Arg Leu Lys Asp  Ile Lys Phe 
    1265                 1270                 1275             


Asp Glu  Asn Gly Asp Phe Lys  Met Val Gly Lys Glu  Gln Asp Leu 
    1280                 1285                 1290             


Ala Thr  Tyr Glu Ala Ile Lys  Gln Arg Tyr Leu Glu  His Arg Lys 
    1295                 1300                 1305             


Asn Ser  Lys Lys Ala Phe Glu  Thr Pro Leu Tyr Lys  Pro Ser Lys 
    1310                 1315                 1320             


Lys Gly  Thr Gly Asn Leu Ile  Lys Arg Val Lys Ile  Glu Gly Gln 
    1325                 1330                 1335             


Thr Lys  Ala Phe Val Arg Glu  Val Asn Gly Gly Val  Ala Gln Asn 
    1340                 1345                 1350             


Ser Asp  Leu Val Arg Val Asp  Leu Phe Glu Lys Asp  Asp Lys Tyr 
    1355                 1360                 1365             


Tyr Met  Val Pro Ile Tyr Val  Pro Asp Thr Val Cys  Ser Glu Leu 
    1370                 1375                 1380             


Pro Lys  Lys Val Val Lys Ser  Gly Lys Gly Tyr Glu  Gln Trp Leu 
    1385                 1390                 1395             


Thr Leu  Asp Asn Ser Phe Thr  Phe Lys Ser Ser Leu  Tyr Pro Tyr 
    1400                 1405                 1410             


Asp Leu  Val Arg Leu Val Lys  Gly Asn Glu Asp Arg  Phe Leu Tyr 
    1415                 1420                 1425             


Phe Gly  Thr Leu Asp Ile Asp  Ser Asp Arg Leu Asn  Phe Lys Asp 
    1430                 1435                 1440             


Val Asn  Lys Pro Ser Lys Gln  Asn Glu Tyr Arg Tyr  Ser Leu Lys 
    1445                 1450                 1455             


Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val Gly Val  Leu Gly Asp 
    1460                 1465                 1470             


Leu Arg  Leu Val Lys Gln Glu  Thr Arg Arg Ile Phe  Asn Arg Pro 
    1475                 1480                 1485             


Lys Lys  Lys Arg Lys Val 
    1490                 


<210> 452
<211> 1494
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Nuc-ADAT-Linker-nAPG08290.1-Linker-SV40"

<400> 452
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
            20                  25                  30          


Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly 
        35                  40                  45              


Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
    50                  55                  60                  


Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
65                  70                  75                  80  


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
                85                  90                  95      


Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
            100                 105                 110         


His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr 
        115                 120                 125             


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn 
    130                 135                 140                 


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
145                 150                 155                 160 


Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln 
                165                 170                 175     


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
            180                 185                 190         


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
        195                 200                 205             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu 
    210                 215                 220                 


Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu 
225                 230                 235                 240 


Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile 
                245                 250                 255     


Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His 
            260                 265                 270         


Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr 
        275                 280                 285             


Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met 
    290                 295                 300                 


Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly 
305                 310                 315                 320 


Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu 
                325                 330                 335     


His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu 
            340                 345                 350         


Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg 
        355                 360                 365             


Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly 
    370                 375                 380                 


Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
385                 390                 395                 400 


Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Met 
                405                 410                 415     


Ser Glu Leu Asp Tyr Arg Ile Gly Leu Ala Ile Gly Thr Asn Ser Ile 
            420                 425                 430         


Gly Trp Gly Val Ile Glu Leu Phe Trp Asn Lys Asp Arg Glu Arg Tyr 
        435                 440                 445             


Glu Lys Val Arg Ile Val Asp Lys Gly Val Arg Met Phe Asp Lys Ala 
    450                 455                 460                 


Glu Ile Pro Asn Lys Gly Ala Ser Leu Ala Glu Pro Arg Arg Ile Ala 
465                 470                 475                 480 


Arg Ser Ser Arg Arg Arg Leu Asn Arg Lys Ser Gln Arg Lys Lys Glu 
                485                 490                 495     


Ile Arg Asn Leu Leu Val Gln His Gly Met Ile Thr Gln Glu Glu Leu 
            500                 505                 510         


Asp Leu Leu Tyr Pro Leu Ser Lys Lys Ser Ile Asp Ile Trp Asp Ile 
        515                 520                 525             


Arg Leu Asp Gly Leu Asp Arg Leu Leu Asn His Leu Glu Trp Ala Arg 
    530                 535                 540                 


Leu Leu Ile His Leu Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys 
545                 550                 555                 560 


Ser Glu Leu Lys Asp Ala Glu Thr Gly Lys Val Leu Ser Ser Ile Gln 
                565                 570                 575     


Val Asn Glu Lys Arg Leu Phe Leu Tyr Arg Thr Val Gly Glu Met Trp 
            580                 585                 590         


Ile Lys Asp Ala Glu Phe Ser Lys Tyr Asp Arg Arg Arg Asn Ser Pro 
        595                 600                 605             


Asn Glu Tyr Val Phe Ser Val Ser Arg Ala Asp Leu Glu Lys Glu Ile 
    610                 615                 620                 


Val Thr Leu Phe Glu Ala Gln Arg Lys Phe Gln Ser Ser Tyr Ala Ser 
625                 630                 635                 640 


Lys Asn Leu Gln Glu Thr Tyr Leu Gln Ile Trp Ala His Gln Leu Pro 
                645                 650                 655     


Phe Ala Ser Gly Asn Ala Ile Leu Asn Lys Val Gly Tyr Cys Ser Leu 
            660                 665                 670         


Leu Lys Gly Lys Glu Arg Arg Ile Pro Lys Ala Thr Tyr Thr Phe Gln 
        675                 680                 685             


Tyr Phe Ser Ala Leu Asp Gln Val Asn Arg Thr Arg Leu Gly Pro Asp 
    690                 695                 700                 


Phe Gln Pro Phe Thr Gln Glu Gln Lys Glu Ile Ile Leu Asp Lys Met 
705                 710                 715                 720 


Phe Gln Arg Thr Asp Tyr Tyr Lys Lys Lys Thr Ile Pro Glu Val Ser 
                725                 730                 735     


Tyr Tyr Asp Ile Arg Lys Trp Leu Glu Leu Asp Glu Thr Ile Gln Phe 
            740                 745                 750         


Lys Gly Leu Asn Tyr Asp Pro Asn Glu Glu Leu Lys Lys Ile Glu Lys 
        755                 760                 765             


Lys Pro Phe Ile Asn Leu Lys Ala Phe Tyr Glu Ile Lys Lys Val Val 
    770                 775                 780                 


Ala Asn Tyr Ala Glu Arg Thr Asn Glu Ala Phe Ser Thr Leu Asp Tyr 
785                 790                 795                 800 


Asp Ala Ile Ala Tyr Ala Leu Thr Val Tyr Lys Thr Asp Lys Asp Ile 
                805                 810                 815     


Arg Ser Tyr Leu Lys Lys Ser Asn Asn Leu Ser Lys Arg Cys Tyr Asp 
            820                 825                 830         


Asp Gln Leu Ile Glu Glu Leu Phe Thr Leu Ser Tyr Thr Lys Phe Gly 
        835                 840                 845             


His Leu Ser Phe Lys Ala Ile Asn His Val Leu Pro Ile Met Gln Glu 
    850                 855                 860                 


Gly Arg Thr Tyr Gln Glu Ala Ile His Gln Leu Gly Tyr Asp Thr Thr 
865                 870                 875                 880 


Asn Leu Lys Lys Glu Asn Arg Ser Met Phe Leu Pro Leu Ile Pro Asp 
                885                 890                 895     


Glu Ile Thr Asn Pro Ile Val Lys Arg Ala Ile Thr Gln Ala Arg Lys 
            900                 905                 910         


Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Asn Ser Val His 
        915                 920                 925             


Ile Glu Leu Ala Arg Glu Leu Ser Lys Ser His Asp Glu Arg Lys Lys 
    930                 935                 940                 


Ile Met Thr Ala His Asp Glu Asn Tyr Lys Lys Asn Lys Gly Ala Ile 
945                 950                 955                 960 


Ser Ile Leu Ile Glu Asn Gly Ile Leu Asn Pro Thr Gly Tyr Asp Ile 
                965                 970                 975     


Val Arg Tyr Lys Leu Trp Lys Glu Gln Gly Glu Arg Cys Ala Tyr Ser 
            980                 985                 990         


Leu Lys Glu Ile Pro Pro Asp Thr  Phe Phe Asn Glu Leu  Lys Lys Glu 
        995                 1000                 1005             


Arg Asn  Gly Ser Pro Ile Leu  Glu Val Asp His Ile  Leu Pro Tyr 
    1010                 1015                 1020             


Ser Gln  Ser Phe Ile Asp Ser  Tyr His Asn Lys Val  Leu Val Tyr 
    1025                 1030                 1035             


Ser Asp  Glu Asn Arg Asn Lys  Gly Asn Arg Ile Pro  Tyr Thr Tyr 
    1040                 1045                 1050             


Phe Leu  Glu Thr Asn Lys Asp  Trp Glu Ala Phe Glu  Arg Tyr Val 
    1055                 1060                 1065             


Arg Ser  Asn Lys Leu Phe Ser  Lys Lys Lys Arg Glu  Tyr Leu Leu 
    1070                 1075                 1080             


Lys Lys  Thr Tyr Leu Pro Arg  Glu Ser Glu Leu Ile  Lys Glu Arg 
    1085                 1090                 1095             


His Leu  Asn Asp Thr Arg Tyr  Ala Ser Thr Phe Leu  Lys Asn Phe 
    1100                 1105                 1110             


Ile Glu  Gln Asn Leu Gln Phe  Lys Glu Val Glu Val  Asn Leu Arg 
    1115                 1120                 1125             


Lys Lys  Arg Val Gln Thr Val  Asn Gly Val Ile Thr  Ala His Leu 
    1130                 1135                 1140             


Arg Lys  Arg Trp Gly Leu Glu  Lys Asn Arg Gln Glu  Thr Tyr Leu 
    1145                 1150                 1155             


His His  Ala Met Asp Ala Ile  Ile Val Ala Cys Thr  Asp His His 
    1160                 1165                 1170             


Met Val  Thr Arg Ile Thr Glu  Tyr Tyr Gln Ile Lys  Glu Ser Asn 
    1175                 1180                 1185             


Lys Ser  Val Lys Lys Pro Tyr  Phe Pro Met Pro Trp  Glu Gly Phe 
    1190                 1195                 1200             


Arg Asp  Glu Leu Leu Ser His  Leu Ala Ser Gln Pro  Ile Ala Lys 
    1205                 1210                 1215             


Lys Ile  Ser Glu Glu Leu Lys  Ala Gly Tyr Gln Ser  Ser Asp Tyr 
    1220                 1225                 1230             


Ile Phe  Val Ser Arg Met Pro  Lys Arg Ser Val Thr  Gly Ala Ala 
    1235                 1240                 1245             


His Asp  Gln Thr Ile Arg Arg  Lys Gly Gly Ile Asp  Lys Lys Gly 
    1250                 1255                 1260             


Lys Thr  Ile Ile Ile Lys Arg  Val Arg Leu Lys Asp  Ile Lys Phe 
    1265                 1270                 1275             


Asp Glu  Asn Gly Asp Phe Lys  Met Val Gly Lys Glu  Gln Asp Leu 
    1280                 1285                 1290             


Ala Thr  Tyr Glu Ala Ile Lys  Gln Arg Tyr Leu Glu  His Arg Lys 
    1295                 1300                 1305             


Asn Ser  Lys Lys Ala Phe Glu  Thr Pro Leu Tyr Lys  Pro Ser Lys 
    1310                 1315                 1320             


Lys Gly  Thr Gly Asn Leu Ile  Lys Arg Val Lys Ile  Glu Gly Gln 
    1325                 1330                 1335             


Thr Lys  Ala Phe Val Arg Glu  Val Asn Gly Gly Val  Ala Gln Asn 
    1340                 1345                 1350             


Ser Asp  Leu Val Arg Val Asp  Leu Phe Glu Lys Asp  Asp Lys Tyr 
    1355                 1360                 1365             


Tyr Met  Val Pro Ile Tyr Val  Pro Asp Thr Val Cys  Ser Glu Leu 
    1370                 1375                 1380             


Pro Lys  Lys Val Val Lys Ser  Gly Lys Gly Tyr Glu  Gln Trp Leu 
    1385                 1390                 1395             


Thr Leu  Asp Asn Ser Phe Thr  Phe Lys Ser Ser Leu  Tyr Pro Tyr 
    1400                 1405                 1410             


Asp Leu  Val Arg Leu Val Lys  Gly Asn Glu Asp Arg  Phe Leu Tyr 
    1415                 1420                 1425             


Phe Gly  Thr Leu Asp Ile Asp  Ser Asp Arg Leu Asn  Phe Lys Asp 
    1430                 1435                 1440             


Val Asn  Lys Pro Ser Lys Gln  Asn Glu Tyr Arg Tyr  Ser Leu Lys 
    1445                 1450                 1455             


Thr Ile  Glu Asn Leu Glu Lys  Tyr Glu Val Gly Val  Leu Gly Asp 
    1460                 1465                 1470             


Leu Arg  Leu Val Lys Gln Glu  Thr Arg Arg Ile Phe  Asn Arg Pro 
    1475                 1480                 1485             


Lys Lys  Lys Arg Lys Val 
    1490                 


<210> 453
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Hurler target 1"

<400> 453
ggagcagctc taggccgaag tgtcg                                             25


<210> 454
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Hurler target 2"

<400> 454
taggccgaag tgtcgcaggc cggga                                             25


<210> 455
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Hurler target 3"

<400> 455
gctctaggcc gaagtgtcgc aggcc                                             25


<210> 456
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA Hurler target 1"

<400> 456
ggagcagctc taggccgaag tgtcggtcat agttccatga aagccaaaag tggctttgat       60

gtttctatga taagggtttc ggcccgtggc gtcggggatc gcctgcccat tccgatgggc      120

ttctccccat ttatt                                                       135


<210> 457
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA Hurler target 2"

<400> 457
taggccgaag tgtcgcaggc cgggagtcat agttccatga aagccaaaag tggctttgat       60

gtttctatga taagggtttc ggcccgtggc gtcggggatc gcctgcccat tccgatgggc      120

ttctccccat ttatt                                                       135


<210> 458
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="sgRNA Hurler target 3"

<400> 458
ggcctgcgac acttcggcct agagcgtcat agttccatga aagccaaaag tggctttgat       60

gtttctatga taagggtttc ggcccgtggc gtcggggatc gcctgcccat tccgatgggc      120

ttctccccat ttatt                                                       135


<210> 459
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Hurler Forward Amplification Primer"

<400> 459
gactccttca ccaag                                                        15


<210> 460
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Hurler Reverse Amplification Primer"

<400> 460
gtagatcagc accg                                                         14


<210> 461
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Hurler Wild Type Probe"

<400> 461
ctctgggccg aagt                                                         14


<210> 462
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Hurler W402X Probe-beta"

<400> 462
ctctaggccg aagt                                                         14


<210> 463
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Hurler NGS forward"

<400> 463
acttcctcca gcc                                                          13


<210> 464
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Hurler NGS Reverse"

<400> 464
gaaccccggc tta                                                          13


<210> 465
<211> 31
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human W402X"

<400> 465
ggagcagctc taggccgaag tgtcgcaggc c                                      31


<210> 466
<211> 31
<212> DNA
<213> Mus musculus

<220>
<221> source
<223> /note="Mouse W392X"

<400> 466
agaacaactc taggcagagg tctcaaaggc t                                      31


<210> 467
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="humanized mouse"

<400> 467
ggagcagctc taggccgaag tgtcgcaggc c                                      31


<210> 468
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="FRDA target 1"

<400> 468
atcacctgag gtccggagtt caaga                                             25


<210> 469
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="FRDA target 2"

<400> 469
gtcttgaact ccggacctca ggtga                                             25


<210> 470
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="FRDA target 3"

<400> 470
tgaactccgg acctcaggtg atcca                                             25


<210> 471
<211> 25
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="FRDA target 4"

<400> 471
gaaaagttag ccgggcgtgg tgtcg                                             25


<210> 472
<211> 500
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="BCL11A enhancer region"

<400> 472
aaaaatggac aattatgagg aggggagagt gcagacaggg gaagcttcac ctcctttaca       60

attttgggag tccacacggc atggcataca aattatttca ttcccattga gaaataaaat      120

ccaattctcc atcaccaaga gagccttccg aaagaggccc ccctgggcaa acggccaccg      180

atggagaggt ctgccagtcc tcttctaccc cacccacgcc cccaccctaa tcagaggcca      240

aacccttcct ggagcctgtg ataaaagcaa ctgttagctt gcactagact agcttcaaag      300

ttgtattgac cctggtgtgt tatgtctaag agtagatgcc atatctcttt tctggcctat      360

gttattacct gtatggactt tgcactggaa tcagctatct gctcttactt atgcacacct      420

ggggcataga gccagccctg tatcgctttt cagccatctc actacagata actcccaagt      480

cctgtctagc tgccttcctt                                                  500


<210> 473
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SCD target seq 1"

<400> 473
gcactagact agcttcaaag ttgtag                                            26


<210> 474
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SCD target seq 2"

<400> 474
cctaatcaga ggccaaaccc ttcctg                                            26


<210> 475
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SCD target seq 3"

<400> 475
caagctaaca gttgctttta tcacag                                            26


<210> 476
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SCD target seq 4"

<400> 476
gcactagact agcttcaaag ttgtag                                            26


<210> 477
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SCD target seq 5"

<400> 477
cctaatcaga ggccaaaccc ttcctg                                            26


<210> 478
<211> 26
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SCD target seq 6"

<400> 478
caagctaaca gttgctttta tcacag                                            26


<210> 479
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RelA FWD"

<400> 479
cttagtttca ccgcaggttc ta                                                22


<210> 480
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RelA REV"

<400> 480
ctgtgcactc aacactgatc ta                                                22


<210> 481
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="AurkB FWD"

<400> 481
cccagcccta ggttgtttat t                                                 21


<210> 482
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="AurkB REV"

<400> 482
ctggctacat cttccttgac tac                                               23


<210> 483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="HPRT1 FWD"

<400> 483
gtggcagaag cagtgagtaa                                                   20


<210> 484
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="HPRT1 REV"

<400> 484
tcccatctag gcactaggta aa                                                22


<210> 485
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 134, Guide 135, Guide 136, Guide 137"

<400> 485
gtctcgtggg ctcggagatg tgtataagag acagacaatt ctcctgcctc agcc             54


<210> 486
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 134, Guide 135, Guide 136, Guide 137"

<400> 486
tcgtcggcag cgtcagatgt gtataagaga cagactgcca tgggaagaag gtg              53


<210> 487
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 138, Guide 139, Guide 140, Guide 141"

<400> 487
gtctcgtggg ctcggagatg tgtataagag acagacaatt ctcctgcctc agcc             54


<210> 488
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 138, Guide 139, Guide 140, Guide 141"

<400> 488
tcgtcggcag cgtcagatgt gtataagaga cagactgcca tgggaagaag gtg              53


<210> 489
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 142, Guide 143, Guide 144, Guide 145"

<400> 489
tcgtcggcag cgtcagatgt gtataagaga caggagctgc acatttgacg agc              53


<210> 490
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 142, Guide 143, Guide 144, Guide 145"

<400> 490
gtctcgtggg ctcggagatg tgtataagag acagattaca ggtgtgagcc acgg             54


<210> 491
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 164, Guide 165, Guide 166, Guide 167"

<400> 491
tcgtcggcag cgtcagatgt gtataagaga cagctgacct caggtgatac gcc              53


<210> 492
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 164, Guide 165, Guide 166, Guide 167"

<400> 492
gtctcgtggg ctcggagatg tgtataagag acagctttgg gaggctgaga cagg             54


<210> 493
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 168, Guide 169, Guide 170, Guide 171"

<400> 493
tcgtcggcag cgtcagatgt gtataagaga cagtgctcta ttgtccaggc tgg              53


<210> 494
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 168, Guide 169, Guide 170, Guide 171"

<400> 494
gtctcgtggg ctcggagatg tgtataagag acagtccagc aggtcagcaa agaa             54


<210> 495
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 172, Guide 173, Guide 174, Guide 175"

<400> 495
tcgtcggcag cgtcagatgt gtataagaga caggcagtat aactggccag cct              53


<210> 496
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 172, Guide 173, Guide 174, Guide 175"

<400> 496
gtctcgtggg ctcggagatg tgtataagag acagtcagtt gaggagttca gcttaa           56


<210> 497
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 185, Guide 186, Guide 187, Guide 188"

<400> 497
tcgtcggcag cgtcagatgt gtataagaga cagtggcccc tatgtggaga tca              53


<210> 498
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 185, Guide 186, Guide 187, Guide 188"

<400> 498
gtctcgtggg ctcggagatg tgtataagag acagggcaga gctcagcctc atag             54


<210> 499
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 189, Guide 190, Guide 191, Guide 192"

<400> 499
tcgtcggcag cgtcagatgt gtataagaga cagatatccc cacttcccct gct              53


<210> 500
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 189, Guide 190, Guide 191, Guide 192"

<400> 500
gtctcgtggg ctcggagatg tgtataagag acagcacctc aaggacagct ctgg             54


<210> 501
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 193, Guide 194, Guide 195, Guide 196"

<400> 501
tcgtcggcag cgtcagatgt gtataagaga cagatatccc cacttcccct gct              53


<210> 502
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 193, Guide 194, Guide 195, Guide 196"

<400> 502
gtctcgtggg ctcggagatg tgtataagag acagcacctc aaggacagct ctgg             54


<210> 503
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 146"

<400> 503
gtctcgtggg ctcggagatg tgtataagag acagacaatt ctcctgcctc agcc             54


<210> 504
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 146"

<400> 504
tcgtcggcag cgtcagatgt gtataagaga cagactgcca tgggaagaag gtg              53


<210> 505
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 147"

<400> 505
gtctcgtggg ctcggagatg tgtataagag acagacaatt ctcctgcctc agcc             54


<210> 506
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 147"

<400> 506
tcgtcggcag cgtcagatgt gtataagaga cagactgcca tgggaagaag gtg              53


<210> 507
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 148"

<400> 507
tcgtcggcag cgtcagatgt gtataagaga cagactgcca tgggaagaag gtg              53


<210> 508
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 148"

<400> 508
gtctcgtggg ctcggagatg tgtataagag acagacaatt ctcctgcctc agcc             54


<210> 509
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 176"

<400> 509
tcgtcggcag cgtcagatgt gtataagaga caggtagctc actgcagcct caa              53


<210> 510
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 176"

<400> 510
gtctcgtggg ctcggagatg tgtataagag acagtgggtg atgaacatac gggt             54


<210> 511
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 177"

<400> 511
tcgtcggcag cgtcagatgt gtataagaga cagtcagact gaagagctat tgtgtga          57


<210> 512
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 177"

<400> 512
gtctcgtggg ctcggagatg tgtataagag acagccccac aaaccgatgt agct             54


<210> 513
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 209"

<400> 513
tcgtcggcag cgtcagatgt gtataagaga cagtggagtg cagtggtgtg atc              53


<210> 514
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 209"

<400> 514
gtctcgtggg ctcggagatg tgtataagag acagttgagg ctgcagtgag ctac             54


<210> 515
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 197"

<400> 515
tcgtcggcag cgtcagatgt gtataagaga cagtggcccc tatgtggaga tca              53


<210> 516
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 197"

<400> 516
gtctcgtggg ctcggagatg tgtataagag acagggcaga gctcagcctc atag             54


<210> 517
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 198"

<400> 517
tcgtcggcag cgtcagatgt gtataagaga cagccaagcc gaccaaacaa gtg              53


<210> 518
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 198"

<400> 518
gtctcgtggg ctcggagatg tgtataagag acaggatgcg ctgactgata gcct             54


<210> 519
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 199"

<400> 519
tcgtcggcag cgtcagatgt gtataagaga cagtggcccc tatgtggaga tca              53


<210> 520
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 199"

<400> 520
gtctcgtggg ctcggagatg tgtataagag acagggcaga gctcagcctc atag             54


<210> 521
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 149"

<400> 521
gtctcgtggg ctcggagatg tgtataagag acagggtaag gggaaactgg aggc             54


<210> 522
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 149"

<400> 522
tcgtcggcag cgtcagatgt gtataagaga cagtccactt tctaagcagg cgg              53


<210> 523
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 150"

<400> 523
gtctcgtggg ctcggagatg tgtataagag acaggtgggc ctggatttcg atct             54


<210> 524
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 150"

<400> 524
tcgtcggcag cgtcagatgt gtataagaga cagatgaaca ggcaggaagt cgg              53


<210> 525
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 151"

<400> 525
tcgtcggcag cgtcagatgt gtataagaga cagcggttct gagttgcctt cct              53


<210> 526
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 151"

<400> 526
gtctcgtggg ctcggagatg tgtataagag acagggtaag gggaaactgg aggc             54


<210> 527
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 179"

<400> 527
tcgtcggcag cgtcagatgt gtataagaga cagtcagtgg tccacatgca agt              53


<210> 528
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 179"

<400> 528
gtctcgtggg ctcggagatg tgtataagag acagaaggca agttgatcgc tcga             54


<210> 529
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 180"

<400> 529
tcgtcggcag cgtcagatgt gtataagaga cagagtggtt ctgttgcaca cgt              53


<210> 530
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 180"

<400> 530
gtctcgtggg ctcggagatg tgtataagag acagtcgctt aagcccagga gttc             54


<210> 531
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 181"

<400> 531
tcgtcggcag cgtcagatgt gtataagaga cagtctggct gatccgtact aatcc            55


<210> 532
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 181"

<400> 532
gtctcgtggg ctcggagatg tgtataagag acagtaggct caagggatgc tcct             54


<210> 533
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 200"

<400> 533
tcgtcggcag cgtcagatgt gtataagaga cagccagagc tgtccttgag gtg              53


<210> 534
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 200"

<400> 534
gtctcgtggg ctcggagatg tgtataagag acaggtccat acccaccttg gcaa             54


<210> 535
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 201"

<400> 535
tcgtcggcag cgtcagatgt gtataagaga cagccaagcc gaccaaacaa gtg              53


<210> 536
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 201"

<400> 536
gtctcgtggg ctcggagatg tgtataagag acaggatgcg ctgactgata gcct             54


<210> 537
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 202"

<400> 537
tcgtcggcag cgtcagatgt gtataagaga cagaggctat cagtcagcgc atc              53


<210> 538
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 202"

<400> 538
gtctcgtggg ctcggagatg tgtataagag acagagcagg ggaagtgggg atat             54


<210> 539
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 152"

<400> 539
gtctcgtggg ctcggagatg tgtataagag acagattaca ggtgtgagcc acgg             54


<210> 540
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 152"

<400> 540
tcgtcggcag cgtcagatgt gtataagaga caggagctgc acatttgacg agc              53


<210> 541
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 153"

<400> 541
gtctcgtggg ctcggagatg tgtataagag acagacaatt ctcctgcctc agcc             54


<210> 542
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 153"

<400> 542
tcgtcggcag cgtcagatgt gtataagaga cagactgcca tgggaagaag gtg              53


<210> 543
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 154"

<400> 543
gtctcgtggg ctcggagatg tgtataagag acagattaca ggtgtgagcc acgg             54


<210> 544
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 154"

<400> 544
tcgtcggcag cgtcagatgt gtataagaga caggagctgc acatttgacg agc              53


<210> 545
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 182"

<400> 545
gtctcgtggg ctcggagatg tgtataagag acagtgggtg atgaacatac gggt             54


<210> 546
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 182"

<400> 546
tcgtcggcag cgtcagatgt gtataagaga caggtagctc actgcagcct caa              53


<210> 547
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 183"

<400> 547
gtctcgtggg ctcggagatg tgtataagag acagtgcctg tagtcccagc tact             54


<210> 548
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 183"

<400> 548
tcgtcggcag cgtcagatgt gtataagaga cagtcagctc agtgcaacct ctg              53


<210> 549
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 184"

<400> 549
gtctcgtggg ctcggagatg tgtataagag acagctttgg gaggctgaga cagg             54


<210> 550
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 184"

<400> 550
tcgtcggcag cgtcagatgt gtataagaga cagctgacct caggtgatac gcc              53


<210> 551
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 203"

<400> 551
gtctcgtggg ctcggagatg tgtataagag acaggatgcg ctgactgata gcct             54


<210> 552
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 203"

<400> 552
tcgtcggcag cgtcagatgt gtataagaga cagccaagcc gaccaaacaa gtg              53


<210> 553
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 204"

<400> 553
gtctcgtggg ctcggagatg tgtataagag acagcacctc aaggacagct ctgg             54


<210> 554
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 204"

<400> 554
tcgtcggcag cgtcagatgt gtataagaga cagatatccc cacttcccct gct              53


<210> 555
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FWD_Guide 205"

<400> 555
gtctcgtggg ctcggagatg tgtataagag acagggcaga gctcagcctc atag             54


<210> 556
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="REV_Guide 205"

<400> 556
tcgtcggcag cgtcagatgt gtataagaga cagtggcccc tatgtggaga tca              53


<210> 557
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="seq in base of hairpin stem of tracrRNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, u, g, unknown or other

<400> 557
unannu                                                                   6


<210> 558
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="seq in base of hairpin stem of tracrRNA"


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, u, g, unknown or other

<400> 558
unanna                                                                   6


<210> 559
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="sequence 2 for cleavage site assay"

<400> 559
ccatgatata gacgttgtgg ctgttgtagt                                        30


<210> 560
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 560
His His His His His His 
1               5       


<210> 561
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      10xHis tag"

<400> 561
His His His His His His His His His His 
1               5                   10  


<210> 562
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 562
cctgggtgtg aggctgggcc attaaaacct ctcc                                   34


<210> 563
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 563
cctgaaaacc tctcc                                                        15


<210> 564
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 564
cctgggtgtg agctgggcca ttaaaacctc tcc                                    33


<210> 565
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 565
cctgggccat taaaacctct cc                                                22


<210> 566
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 566
cctggctctc c                                                            11


<210> 567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 567
cgggccatta aaacctctcc                                                   20


<210> 568
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 568
cctgggtgtg aggccagacc tgggccatta aaacctctcc                             40


<210> 569
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 569
cctgggtgtg aggggaagct gacgtccttt ccatggctgc tcgcctgtgt tgccaccgct       60

gggccattaa aacctctcc                                                    79


<210> 570
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 570
cctgggtgtg acctgggcca ttaaaacctc tcc                                    33


<210> 571
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 571
cctgggtgtg aggactgggc cattaaaacc tctcc                                  35


<210> 572
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 572
agttggcaga tgctctaatg tactgccatg ggaa                                   34


<210> 573
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 573
agttggcaga tgcaatgtac tgccatggga a                                      31


<210> 574
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 574
agttggcaga tgcatgtact gccatgggaa                                        30


<210> 575
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 575
agttggcaga tgctatgtac tgccatggga a                                      31


<210> 576
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 576
agttggcaga tgctaatgta ctgccatggg aa                                     32


<210> 577
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 577
agttggcaga tgctatgtaa tgccatggga a                                      31


<210> 578
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 578
agttggcaga tgctctatgt actgccatgg gaa                                    33


<210> 579
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 579
cgacctgaat gctgtgcggc gctctggctt cattcaatc                              39


<210> 580
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 580
cgacctgaat gctgtgcggc tctgcttcca ggtga                                  35


<210> 581
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 581
cgacctgaat gctgtgcggc atctgcttcc aggtga                                 36


<210> 582
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 582
cgacctgaat gctgcttcca ggtga                                             25


<210> 583
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 583
cgacctgaat gcttctgctt ccaggtga                                          28


<210> 584
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 584
cgacctgaat gcttccaggt ga                                                22


<210> 585
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 585
gcgtggggac tacgacctga atgctgtgcg gctct                                  35


<210> 586
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 586
gcgacctgaa tgctgtgcgg ctct                                              24


<210> 587
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 587
gcgtggggac tacgagctgt gcggctct                                          28


<210> 588
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 588
gcgtggggac tgaatgctgt gcggctct                                          28


<210> 589
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 589
gcgtggggac tcctgaatgc tgtgcggctc t                                      31


<210> 590
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 590
gcgtggggac tacgaacctg aatgctgtgc ggctct                                 36


<210> 591
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 591
gcgtggggac tacgaatgct gtgcggctct                                        30


<210> 592
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 592
gcgtggggac tacctgaatg ctgtgcggct ct                                     32


<210> 593
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 593
gcgtgaatgc tgtgcggctc t                                                 21


<210> 594
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 594
gcgacctgac tgctgtgcgg ctct                                              24


<210> 595
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 595
gcgtggggac tacgcctgaa tgctgtgcgg ctct                                   34


<210> 596
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 596
atggaggagt tggcagatgc tctaatgtac tgccatggga ag                          42


<210> 597
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 597
atggaggagt tggcagatgc taatgtactg ccatgggaag                             40


<210> 598
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 598
atggaggagt tggcagatgt actgccatgg gaag                                   34


<210> 599
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 599
atgtactgcc atgggaag                                                     18


<210> 600
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 600
atggaggagt tggtgtactg ccatgggaag                                        30


<210> 601
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 601
atggaggagt tggcagatgc tctaaatgta ctgccatggg aag                         43


<210> 602
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 602
atggaggagt tggcagatgc tcttctaatg tactgccatg ggaag                       45


<210> 603
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 603
atggaggagt tggcagatgc cctctaatgt actgccatgg gaag                        44


<210> 604
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 604
atggaggagt tggcagataa tgtactgcca tgggaagaag                             40


<210> 605
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 605
atggcgtact gccatgggaa gaag                                              24


<210> 606
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 606
atggaggagt tggcagatgc ttctaatgta ctgccatggg aagaag                      46


<210> 607
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 607
atggaggagt tggcatctgc catgggaaga ag                                     32


<210> 608
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 608
atggaggagt tggcagatgc aatgtactgc catgggaaga ag                          42


<210> 609
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 609
atggaggagt tggcagatgc caaactgaaa aacaaatcaa agcactctta ttgagtgctg       60

gcgatccccg acgccacggg ccgaaaccct tatcatagaa actctaatgt actgccatgg      120

gaag                                                                   124


<210> 610
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 610
atggaggagt tggcagatgc tgcttatata gacctcccac cgtacacgcc taccgcccat       60

tttctaatgt actgccatgg gaag                                              84


<210> 611
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 611
atggaggagt tgtctaatgt actgccatgg gaag                                   34


<210> 612
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 612
ctgccatggg aagaag                                                       16


<210> 613
<211> 90
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 613
atggaggagt tggcagatgc gcggctgttc ctgtacagaa ccgtgggcga gatgtggatc       60

aaggatgctc taatgtactg ccatgggaag                                        90


<210> 614
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 614
atggaggagt tggcagatgc ctaatgtact gccatgggaa g                           41


<210> 615
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 615
atggaggagt tggcagatgc tgtcatgatc tttttccgct cgtcgtggga cttgctcagt       60

tctctggcca gctcgtctaa tgtactgcca tgggaag                                97


<210> 616
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 616
atggaggagt tggcagatgc tctatgtact gccatgggaa g                           41


<210> 617
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 617
cagggacagt gcgcatctcc ctggtcacca ag                                     32


<210> 618
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 618
cagggacagt caccaag                                                      17


<210> 619
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 619
cagggacagt gcgcatctcc tggtcaccaa g                                      31


<210> 620
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 620
cagggacagt gcgcatctct ggtcaccaag                                        30


<210> 621
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 621
cagggacagt gcgcatctcc tctggtcacc aag                                    33


<210> 622
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 622
cagggacagt gcgcatcctg gtcaccaag                                         29


<210> 623
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 623
cagggacggt caccaag                                                      17


<210> 624
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 624
cggggacagg gcgcatctcc tggtcaccaa g                                      31


<210> 625
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 625
cgacctgaat gctgtgcggc tctgcttcca gg                                     32


<210> 626
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 626
cgacctgaat gctgtgcggc atctgcttcc agg                                    33


<210> 627
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 627
cgacctgaat gctgtgcggc ttctgcttcc agg                                    33


<210> 628
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 628
cgacctgaat gctgtgtctg cttccagg                                          28


<210> 629
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 629
cgacctgcat gctgtgcggc atctgcttcc agg                                    33


<210> 630
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 630
cgacctgcat gctgtgcggc ttctgcttcc agg                                    33


<210> 631
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 631
cgacctgcat gctgtgtctg cttccagg                                          28


<210> 632
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 632
cgacctgaat gctgtgcgac atctgcttcc agg                                    33


<210> 633
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 633
tggggactac gacctgaatg ctgtgcggct ct                                     32


<210> 634
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 634
tggggactac gaatgctgtg cggctct                                           27


<210> 635
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 635
tggggactac gagcaggcag aagtatgcaa agcatgcatc tcaattcctg aatgctgtgc       60

ggctct                                                                  66


<210> 636
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 636
tggggactac gaagaaggcg atagaaggcc atgcgctgcg aatcgggagc ggcctgaatg       60

ctgtgcggct ct                                                           72


<210> 637
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 637
tggggactac gatgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca       60

ctcaaaggcg gtaatacggc ctgaatgctg tgcggctct                              99


<210> 638
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 638
tggggtgcgg ctct                                                         14


<210> 639
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 639
tggggactac gactgctgtg cggctct                                           27


<210> 640
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 640
cgacctgaat gctgtgcggc gctctggctt cattcaatc                              39


<210> 641
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 641
cgacctgaat gctgtgcggc tctgcttcca ggtga                                  35


<210> 642
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 642
cgacctgaat gctgtgcggc atctgcttcc aggtga                                 36


<210> 643
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 643
cgacctgaat gctgcttcca ggtga                                             25


<210> 644
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 644
cgacctgaat gcttctgctt ccaggtga                                          28


<210> 645
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 645
cgacctgaat gcttccaggt ga                                                22


<210> 646
<211> 4
<212> PRT
<213> Homo sapiens

<400> 646
Glu Glu Gln Leu 
1               


<210> 647
<211> 6
<212> PRT
<213> Homo sapiens

<400> 647
Ala Glu Val Ser Gln Ala 
1               5       


<210> 648
<211> 4
<212> PRT
<213> Mus musculus

<400> 648
Gly Glu Gln Leu 
1               


<210> 649
<211> 6
<212> PRT
<213> Mus musculus

<400> 649
Ala Glu Val Ser Lys Ala 
1               5       


<210> 650
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 650
Gly Glu Gln Leu 
1               


<210> 651
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 651
Ala Glu Val Ser Gln Ala 
1               5       


