                               SEQUENCE LISTING

<110> KING'S COLLEGE LONDON
      GAMMADELTA THERAPEUTICS LIMITED
 
<120> BTNL3/8 TARGETING CONSTRUCTS FOR DELIVERY OF PAYLOADS TO THE 
      GASTROINTESTINAL SYSTEM

<130> GDT-P2577PCT

<140>
<141>

<150> 62/680,932
<151> 2018-06-05

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 4
<212> PRT
<213> Homo sapiens

<400> 1
Asp Thr Tyr Gly 
1               


<210> 2
<211> 4
<212> PRT
<213> Mus sp.

<400> 2
His Val Tyr Glu 
1               


<210> 3
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3
Lys Tyr Asp Thr Tyr Gly Ser Thr Arg Lys Asn Leu Arg Met Ile Leu 
1               5                   10                  15      


<210> 4
<211> 16
<212> PRT
<213> Mus sp.

<400> 4
Lys Tyr His Val Tyr Glu Gly Pro Asp Lys Arg Tyr Lys Phe Val Leu 
1               5                   10                  15      


<210> 5
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5
Lys Tyr Tyr Thr Tyr Ala Ser Thr Arg Asn Asn Leu Arg Leu Ile Leu 
1               5                   10                  15      


<210> 6
<211> 100
<212> PRT
<213> Homo sapiens

<400> 6
Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile Arg Gln Thr Gly 
1               5                   10                  15      


Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu Gly Ser Thr Gly Tyr 
            20                  25                  30          


Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu Leu 
        35                  40                  45              


Tyr Tyr Asp Ser Tyr Thr Ser Ser Val Val Leu Glu Ser Gly Ile Ser 
    50                  55                  60                  


Pro Gly Lys Tyr Asp Thr Tyr Gly Ser Thr Arg Lys Asn Leu Arg Met 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Trp Asp Gly 
            100 


<210> 7
<211> 100
<212> PRT
<213> Homo sapiens

<400> 7
Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile Arg Gln Thr Gly 
1               5                   10                  15      


Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu Gly Ser Asn Gly Tyr 
            20                  25                  30          


Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu Gln 
        35                  40                  45              


Tyr Tyr Asp Ser Tyr Asn Ser Lys Val Val Leu Glu Ser Gly Val Ser 
    50                  55                  60                  


Pro Gly Lys Tyr Tyr Thr Tyr Ala Ser Thr Arg Asn Asn Leu Arg Leu 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Trp Asp Gly 
            100 


<210> 8
<211> 98
<212> PRT
<213> Mus sp.

<400> 8
Ser Ser Asn Leu Glu Glu Arg Ile Met Ser Ile Thr Lys Leu Glu Gly 
1               5                   10                  15      


Ser Ser Ala Ile Met Thr Cys Asp Thr His Arg Thr Gly Thr Tyr Ile 
            20                  25                  30          


His Trp Tyr Arg Phe Gln Lys Gly Arg Ala Pro Glu His Leu Leu Tyr 
        35                  40                  45              


Tyr Asn Phe Val Ser Ser Thr Thr Val Val Asp Ser Arg Phe Asn Ser 
    50                  55                  60                  


Glu Lys Tyr His Val Tyr Glu Gly Pro Asp Lys Arg Tyr Lys Phe Val 
65                  70                  75                  80  


Leu Arg Asn Val Glu Glu Ser Asp Ser Ala Leu Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Trp Ala 
        


<210> 9
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Ala Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg 
1               5                   10                  15      


Lys Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr 
            20                  25                  30          


Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Val Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Ser 
                85                  90                  95      


Leu Thr Arg Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr 
            100                 105                 110         


Val Glu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
        115                 120                 125             


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
                165                 170                 175     


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
            180                 185                 190         


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
        195                 200                 205             


Ser Cys Thr Thr Ala Pro Ser Ala Gln Leu Lys Lys Lys Leu Gln Ala 
    210                 215                 220                 


Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys 
225                 230                 235                 240 


Lys Lys Leu Ala Gln Gly Ser Gly His His His His His His 
                245                 250                 


<210> 10
<211> 270
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile Arg Gln Thr Gly 
1               5                   10                  15      


Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu Gly Ser Thr Gly Tyr 
            20                  25                  30          


Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu Leu 
        35                  40                  45              


Tyr Tyr Asp Ser Tyr Thr Ser Ser Val Val Leu Glu Ser Gly Ile Ser 
    50                  55                  60                  


Pro Gly Lys Tyr Asp Thr Tyr Gly Ser Thr Arg Lys Asn Leu Arg Met 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Trp Asp Glu Lys Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr 
            100                 105                 110         


Leu Val Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
        115                 120                 125             


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
                165                 170                 175     


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
    210                 215                 220                 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Thr Thr Ala Pro Ser Ala Gln Leu Glu 
                245                 250                 255     


Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln Leu Glu 
            260                 265                 270 


<210> 11
<211> 255
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      


Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          


Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Ile Thr Phe 
        35                  40                  45              


Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  


Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  


Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Leu Gly Glu 
                85                  90                  95      


Ser Leu Thr Arg Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val 
            100                 105                 110         


Thr Val Glu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
        115                 120                 125             


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
    130                 135                 140                 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
145                 150                 155                 160 


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
                165                 170                 175     


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
            180                 185                 190         


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
        195                 200                 205             


Ser Ser Cys Thr Thr Ala Pro Ser Ala Gln Leu Lys Lys Lys Leu Gln 
    210                 215                 220                 


Ala Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp Lys Leu Gln Ala Leu 
225                 230                 235                 240 


Lys Lys Lys Leu Ala Gln Gly Ser Gly His His His His His His 
                245                 250                 255 


<210> 12
<211> 282
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile Arg Gln Thr Gly 
1               5                   10                  15      


Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu Gly Ser Asn Gly Tyr 
            20                  25                  30          


Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu Gln 
        35                  40                  45              


Tyr Tyr Asp Ser Tyr Asn Ser Lys Val Val Leu Glu Ser Gly Val Ser 
    50                  55                  60                  


Pro Gly Lys Tyr Tyr Thr Tyr Ala Ser Thr Arg Asn Asn Leu Arg Leu 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Trp Asp Glu Lys Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr 
            100                 105                 110         


Leu Val Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
        115                 120                 125             


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
                165                 170                 175     


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
    210                 215                 220                 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Thr Thr Ala Pro Ser Ala Gln Leu Glu 
                245                 250                 255     


Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln Leu Glu Trp Glu 
            260                 265                 270         


Leu Gln Ala Leu Glu Lys Glu Leu Ala Gln 
        275                 280         


<210> 13
<211> 282
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Pro Thr Gly 
1               5                   10                  15      


Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val Glu Asn Ala Val Tyr 
            20                  25                  30          


Thr His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu Leu 
        35                  40                  45              


Tyr Tyr Asp Ser Tyr Asn Ser Arg Val Val Leu Glu Ser Gly Ile Ser 
    50                  55                  60                  


Arg Glu Lys Tyr His Thr Tyr Ala Ser Thr Gly Lys Ser Leu Lys Phe 
65                  70                  75                  80  


Ile Leu Glu Asn Leu Ile Glu Arg Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Trp Asp Glu Lys Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr 
            100                 105                 110         


Leu Val Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
        115                 120                 125             


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
                165                 170                 175     


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
    210                 215                 220                 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Thr Thr Ala Pro Ser Ala Gln Leu Glu 
                245                 250                 255     


Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln Leu Glu Trp Glu 
            260                 265                 270         


Leu Gln Ala Leu Glu Lys Glu Leu Ala Gln 
        275                 280         


<210> 14
<211> 18
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala Ser 
1               5                   10                  15      


Gln Lys 
        


<210> 15
<211> 20
<212> PRT
<213> Homo sapiens

<400> 15
Gly Gln Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly Thr Lys 
1               5                   10                  15      


Leu Ile Ile Thr 
            20  


<210> 16
<211> 20
<212> PRT
<213> Homo sapiens

<400> 16
Gly Gln Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly Thr Lys 
1               5                   10                  15      


Leu Ile Ile Thr 
            20  


<210> 17
<211> 19
<212> PRT
<213> Homo sapiens

<400> 17
Ser Ser Asp Trp Ile Lys Thr Phe Ala Lys Gly Thr Arg Leu Ile Val 
1               5                   10                  15      


Thr Ser Pro 
            


<210> 18
<211> 16
<212> PRT
<213> Homo sapiens

<400> 18
Asn Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
1               5                   10                  15      


