﻿
                         SEQUENCE LISTING

<110>  UWA
<120>  Proteins and their use for Nucleotide Binding
<130>  276400
<160>  39    
<170>  PatentIn version 3.5

<210>  1
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
1               5                   10                  15      

Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
            20                  25                  30          

Val Pro Asn 
        35  


<210>  2
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
1               5                   10                  15      

Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
            20                  25                  30          

Val Pro Asp 
        35  


<210>  3
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Val Thr Tyr Thr Asn Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
1               5                   10                  15      

Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
            20                  25                  30          

Val Pro Ser 
        35  


<210>  4
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Val Thr Tyr Thr Asn Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
1               5                   10                  15      

Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
            20                  25                  30          

Val Pro Asp 
        35  


<210>  5
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Asn Ser 
1               


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 
1               5                   10                  15  


<210>  8
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala Leu Ser Gly 
1               5                   10                  15      


Thr Arg His 
            
<210>  9
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  9
ctagacctgt catcattagg gttagggtt                                         29

<210>  10
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  10
ctagacctgt catcattagg gttagggtta g                                      31

<210>  11
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  11
ctagacctgt catcattagg gttagggtta ggg                                    33

<210>  12
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  12
ctagacctgt catcattagg gttagggtta gggtt                                  35

<210>  13
<211>  46
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (18)..(27)
<223>  n is a, c, g, t or u

<400>  13
ctttatccag ccctcacnnn nnnnnnncta tagtgtcacc taaatc                      46

<210>  14
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  14
tcgtcggcag cgtcagatgt gtataagaga cagctttatc cagccctcac                  50

<210>  15
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  15
gtctcgtggg ctcggagatg tgtataagag acaggattta ggtgacacta tag              53

<210>  16
<211>  60
<212>  DNA
<213>  Homo sapiens / Nuclear Localization Signal (NLS)

<400>  16
atggataaag cggaattaat tcccgagcct ccaaaaaaga agagaaaggt cgaattgggt       60


<210>  17
<211>  717
<212>  DNA
<213>  Homo sapiens / Enhanced green fluorescent protein (EGFP)

<400>  17
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210>  18
<211>  720
<212>  DNA
<213>  Homo sapiens / Superfolder green fluorescent protein (sfGFP)

<400>  18
atgggtagca aaggagaaga acttttcact ggagttgtcc caattcttgt tgaattagat       60

ggtgatgtta atgggcacaa attttctgtc cgtggagagg gtgaaggtga tgctacaaac      120

ggaaaactca cccttaaatt tatttgcact actggaaaac tacctgttcc gtggccaaca      180

cttgtcacta ctctgaccta tggtgttcaa tgcttttccc gttatccgga tcacatgaaa      240

cggcatgact ttttcaagag tgccatgccc gaaggttatg tacaggaacg cactatatct      300

ttcaaagatg acgggaccta caagacgcgt gctgaagtca agtttgaagg tgataccctt      360

gttaatcgta tcgagttaaa gggtattgat tttaaagaag atggaaacat tcttggacac      420

aaactcgagt acaactttaa ctcacacaat gtatacatca cggcagacaa acaaaagaat      480

ggaatcaaag ctaacttcaa aattcgccac aacgttgaag atggttccgt tcaactagca      540

gaccattatc aacaaaatac tccaattggc gatggccctg tccttttacc agacaaccat      600

tacctgtcga cacaatctgt cctttcgaaa gatcccaacg aaaagcgtga ccacatggtc      660

cttcttgagt ttgtaactgc tgctgggatt acacatggca tggacgagct gtacaagggt      720


<210>  19
<211>  12
<212>  DNA
<213>  Homo sapiens / Linker 1

<400>  19
ggtggcgcgc cc                                                           12


<210>  20
<211>  1104
<212>  DNA
<213>  Homo sapiens / cPPR-Telo1

<400>  20
atggggaatt cagtcaccta caatacccta atctctggac tgggaaaggc tggtcgctta       60

gaagaggctt tagaactgtt cgaggagatg aaagaaaaag gcatagttcc cgatgttgtg      120

acatacaaca cactcatcag tggtcttgga aaagcaggcc ggcttgagga agctctggaa      180

ttgttcgagg aaatgaagga gaaggggatc gtgccggatg tggttacata cacaacgctt      240

attagcggcc tcggcaaggc tggccgtctg gaggaggcgc ttgagttgtt cgaagagatg      300

aaagagaaag gtatagttcc gaacgtggtg acgtatacta cactcatctc cggtctaggc      360

aaagccggga gattggagga agcgctagaa ctgttcgaag aaatgaaaga gaagggtata      420

gtaccagacg tagtcacata taccacgttg atctctggcc tgggcaaagc cggtcgtctt      480

gaagaagcgc tggaattatt tgaggagatg aaggaaaagg gtattgtgcc cgacgttgtg      540

acgtacacaa cgttgatcag tggccttggg aaagcgggac gtctggaaga agccctcgaa      600

ttatttgaag aaatgaagga aaaaggtatt gttccggatg ttgtaactta caacacgctg      660

ataagtggtc tgggcaaagc tggacgctta gaggaggcct tagagctctt tgaggaaatg      720

aaagaaaagg ggattgtgcc tgacgtggtc acatataaca ccctgattag tggcttaggc      780

aaagcaggta gactggagga agcgctggag ctgtttgaag agatgaagga gaaagggatt      840

gttccagacg ttgttaccta tactacgctc atttctgggc tgggtaaagc aggcaggtta      900

gaagaagcac tcgaactctt tgaagagatg aaggagaaag gtatcgttcc caacgtagta      960

acctacacta cgctgatatc cggcttaggt aaagccggtc ggctggagga agctctcgaa     1020

ctgtttgaag aaatgaagga aaaaggaatt gttccagatg ttgttacata tacgacgttg     1080

ataagcgggc tcggtaaagc tgga                                            1104


<210>  21
<211>  21
<212>  DNA
<213>  Homo sapiens / Linker 2

<400>  21
gttgatactg gaaacgctag c                                                 21


<210>  22
<211>  960
<212>  DNA
<213>  Homo sapiens / Pot1(ΔOB)

<400>  22
ccaagctctg gatcagtatc attatacgag gtagaaagat gtcaacagct atctgctaca       60

atacttacag atcatcagta tttggagagg acaccactat gtgccatttt gaaacaaaaa      120

gctcctcaac aataccgcat ccgagcaaaa ttgaggtcat ataagcccag aagactattt      180

cagtctgtta aacttcattg ccctaaatgt catttgctgc aagaagttcc acatgagggc      240

gatttggata taatttttca ggatggtgca actaaaaccc cagatgtcaa gctacaaaat      300

acatcattat atgattcaaa aatctggacc actaaaaatc aaaaaggacg aaaagtagca      360

gttcattttg tgaaaaataa tggtattctc ccgctttcaa atgaatgtct acttttgata      420

gaaggaggta cactcagtga aatttgcaaa ctctcgaaca agtttaatag tgtaattcct      480

gtgagatctg gccacgaaga cctggaactt ttggaccttt cagcaccatt tcttatacaa      540

ggaacaatac atcactatgg atgtaaacag tgttctagtt tgagatccat acaaaatcta      600

aattccctgg ttgataaaac atcgtggatt ccttcttctg tggcagaagc actgggtatt      660

gtacccctcc aatatgtgtt tgttatgacc tttacacttg atgatggaac aggagtacta      720

gaagcctatc tcatggattc tgacaaattc ttccagattc cagcatcaga agttctgatg      780

gatgatgacc ttcagaaaag tgtggatatg atcatggata tgttttgtcc tccaggaata      840

aaaattgatg catatccgtg gttggaatgc ttcatcaagt catacaatgt cacaaatgga      900

acagataatc aaatttgcta tcagattttt gacaccacag ttgcagaaga tgtaatctaa      960


<210>  23
<211>  1104
<212>  DNA
<213>  Homo sapiens / cPPR-Telo2

<400>  23
atggggaatt cagtcaccta cactacccta atctctggac tgggaaaggc tggtcgctta       60

gaagaggctt tagaactgtt cgaggagatg aaagaaaaag gcatagttcc cgatgttgtg      120

acatacacca cactcatcag tggtcttgga aaagcaggcc ggcttgagga agctctggaa      180

ttgttcgagg aaatgaagga gaaggggatc gtgccggatg tggttacata caacacgctt      240

attagcggcc tcggcaaggc tggccgtctg gaggaggcgc ttgagttgtt cgaagagatg      300

aaagagaaag gtatagttcc ggacgtggtg acgtataata cactcatctc cggtctaggc      360

aaagccggga gattggagga agcgctagaa ctgttcgaag aaatgaaaga gaagggtata      420

gtaccagacg tagtcacata taccacgttg atctctggcc tgggcaaagc cggtcgtctt      480

gaagaagcgc tggaattatt tgaggagatg aaggaaaagg gtattgtgcc caacgttgtg      540

acgtacacca cgttgatcag tggccttggg aaagcgggac gtctggaaga agccctcgaa      600

ttatttgaag aaatgaagga aaaaggtatt gttccggatg ttgtaactta caccacgctg      660

ataagtggtc tgggcaaagc tggacgctta gaggaggcct tagagctctt tgaggaaatg      720

aaagaaaagg ggattgtgcc tgacgtggtc acatatacca ccctgattag tggcttaggc      780

aaagcaggta gactggagga agcgctggag ctgtttgaag agatgaagga gaaagggatt      840

gttccagacg ttgttaccta taatacgctc atttctgggc tgggtaaagc aggcaggtta      900

gaagaagcac tcgaactctt tgaagagatg aaggagaaag gtatcgttcc cgacgtagta      960

acctacaata cgctgatatc cggcttaggt aaagccggtc ggctggagga agctctcgaa     1020

ctgtttgaag aaatgaagga aaaaggaatt gttccagatg ttgttacata tactacgttg     1080

ataagcgggc tcggtaaagc tgga                                            1104


<210>  24
<211>  2874
<212>  DNA
<213>  Homo sapiens / NLS-EGFP-linker 1-cPPR-Telo1-linker 2-POT1(ΔOB)

<400>  24
atggataaag cggaattaat tcccgagcct ccaaaaaaga agagaaaggt cgaattgggt       60

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      120

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      180

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      240

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      300

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      360

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      420

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      480

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      540

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      600

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      660

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      720

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggt      780

ggcgcgccca tggggaattc agtcacctac aataccctaa tctctggact gggaaaggct      840

ggtcgcttag aagaggcttt agaactgttc gaggagatga aagaaaaagg catagttccc      900

gatgttgtga catacaacac actcatcagt ggtcttggaa aagcaggccg gcttgaggaa      960

gctctggaat tgttcgagga aatgaaggag aaggggatcg tgccggatgt ggttacatac     1020

acaacgctta ttagcggcct cggcaaggct ggccgtctgg aggaggcgct tgagttgttc     1080

gaagagatga aagagaaagg tatagttccg aacgtggtga cgtatactac actcatctcc     1140

ggtctaggca aagccgggag attggaggaa gcgctagaac tgttcgaaga aatgaaagag     1200

aagggtatag taccagacgt agtcacatat accacgttga tctctggcct gggcaaagcc     1260

ggtcgtcttg aagaagcgct ggaattattt gaggagatga aggaaaaggg tattgtgccc     1320

gacgttgtga cgtacacaac gttgatcagt ggccttggga aagcgggacg tctggaagaa     1380

gccctcgaat tatttgaaga aatgaaggaa aaaggtattg ttccggatgt tgtaacttac     1440

aacacgctga taagtggtct gggcaaagct ggacgcttag aggaggcctt agagctcttt     1500

gaggaaatga aagaaaaggg gattgtgcct gacgtggtca catataacac cctgattagt     1560

ggcttaggca aagcaggtag actggaggaa gcgctggagc tgtttgaaga gatgaaggag     1620

aaagggattg ttccagacgt tgttacctat actacgctca tttctgggct gggtaaagca     1680

ggcaggttag aagaagcact cgaactcttt gaagagatga aggagaaagg tatcgttccc     1740

aacgtagtaa cctacactac gctgatatcc ggcttaggta aagccggtcg gctggaggaa     1800

gctctcgaac tgtttgaaga aatgaaggaa aaaggaattg ttccagatgt tgttacatat     1860

acgacgttga taagcgggct cggtaaagct ggagttgata ctggaaacgc tagcccaagc     1920

tctggatcag tatcattata cgaggtagaa agatgtcaac agctatctgc tacaatactt     1980

acagatcatc agtatttgga gaggacacca ctatgtgcca ttttgaaaca aaaagctcct     2040

caacaatacc gcatccgagc aaaattgagg tcatataagc ccagaagact atttcagtct     2100

gttaaacttc attgccctaa atgtcatttg ctgcaagaag ttccacatga gggcgatttg     2160

gatataattt ttcaggatgg tgcaactaaa accccagatg tcaagctaca aaatacatca     2220

ttatatgatt caaaaatctg gaccactaaa aatcaaaaag gacgaaaagt agcagttcat     2280

tttgtgaaaa ataatggtat tctcccgctt tcaaatgaat gtctactttt gatagaagga     2340

ggtacactca gtgaaatttg caaactctcg aacaagttta atagtgtaat tcctgtgaga     2400

tctggccacg aagacctgga acttttggac ctttcagcac catttcttat acaaggaaca     2460

atacatcact atggatgtaa acagtgttct agtttgagat ccatacaaaa tctaaattcc     2520

ctggttgata aaacatcgtg gattccttct tctgtggcag aagcactggg tattgtaccc     2580

ctccaatatg tgtttgttat gacctttaca cttgatgatg gaacaggagt actagaagcc     2640

tatctcatgg attctgacaa attcttccag attccagcat cagaagttct gatggatgat     2700

gaccttcaga aaagtgtgga tatgatcatg gatatgtttt gtcctccagg aataaaaatt     2760

gatgcatatc cgtggttgga atgcttcatc aagtcataca atgtcacaaa tggaacagat     2820

aatcaaattt gctatcagat ttttgacacc acagttgcag aagatgtaat ctaa           2874


<210>  25
<211>  2874
<212>  DNA
<213>  Homo sapiens / NLS-EGFP-linker 1-cPPR-Telo2-linker 2-POT1(ΔOB)

<400>  25
atggataaag cggaattaat tcccgagcct ccaaaaaaga agagaaaggt cgaattgggt       60

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      120

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      180

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      240

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      300

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      360

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      420

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      480

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      540

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      600

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      660

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      720

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggt      780

ggcgcgccca tggggaattc agtcacctac actaccctaa tctctggact gggaaaggct      840

ggtcgcttag aagaggcttt agaactgttc gaggagatga aagaaaaagg catagttccc      900

gatgttgtga catacaccac actcatcagt ggtcttggaa aagcaggccg gcttgaggaa      960

gctctggaat tgttcgagga aatgaaggag aaggggatcg tgccggatgt ggttacatac     1020

aacacgctta ttagcggcct cggcaaggct ggccgtctgg aggaggcgct tgagttgttc     1080

gaagagatga aagagaaagg tatagttccg gacgtggtga cgtataatac actcatctcc     1140

ggtctaggca aagccgggag attggaggaa gcgctagaac tgttcgaaga aatgaaagag     1200

aagggtatag taccagacgt agtcacatat accacgttga tctctggcct gggcaaagcc     1260

ggtcgtcttg aagaagcgct ggaattattt gaggagatga aggaaaaggg tattgtgccc     1320

aacgttgtga cgtacaccac gttgatcagt ggccttggga aagcgggacg tctggaagaa     1380

gccctcgaat tatttgaaga aatgaaggaa aaaggtattg ttccggatgt tgtaacttac     1440

accacgctga taagtggtct gggcaaagct ggacgcttag aggaggcctt agagctcttt     1500

gaggaaatga aagaaaaggg gattgtgcct gacgtggtca catataccac cctgattagt     1560

ggcttaggca aagcaggtag actggaggaa gcgctggagc tgtttgaaga gatgaaggag     1620

aaagggattg ttccagacgt tgttacctat aatacgctca tttctgggct gggtaaagca     1680

ggcaggttag aagaagcact cgaactcttt gaagagatga aggagaaagg tatcgttccc     1740

gacgtagtaa cctacaatac gctgatatcc ggcttaggta aagccggtcg gctggaggaa     1800

gctctcgaac tgtttgaaga aatgaaggaa aaaggaattg ttccagatgt tgttacatat     1860

actacgttga taagcgggct cggtaaagct ggagttgata ctggaaacgc tagcccaagc     1920

tctggatcag tatcattata cgaggtagaa agatgtcaac agctatctgc tacaatactt     1980

acagatcatc agtatttgga gaggacacca ctatgtgcca ttttgaaaca aaaagctcct     2040

caacaatacc gcatccgagc aaaattgagg tcatataagc ccagaagact atttcagtct     2100

gttaaacttc attgccctaa atgtcatttg ctgcaagaag ttccacatga gggcgatttg     2160

gatataattt ttcaggatgg tgcaactaaa accccagatg tcaagctaca aaatacatca     2220

ttatatgatt caaaaatctg gaccactaaa aatcaaaaag gacgaaaagt agcagttcat     2280

tttgtgaaaa ataatggtat tctcccgctt tcaaatgaat gtctactttt gatagaagga     2340

ggtacactca gtgaaatttg caaactctcg aacaagttta atagtgtaat tcctgtgaga     2400

tctggccacg aagacctgga acttttggac ctttcagcac catttcttat acaaggaaca     2460

atacatcact atggatgtaa acagtgttct agtttgagat ccatacaaaa tctaaattcc     2520

ctggttgata aaacatcgtg gattccttct tctgtggcag aagcactggg tattgtaccc     2580

ctccaatatg tgtttgttat gacctttaca cttgatgatg gaacaggagt actagaagcc     2640

tatctcatgg attctgacaa attcttccag attccagcat cagaagttct gatggatgat     2700

gaccttcaga aaagtgtgga tatgatcatg gatatgtttt gtcctccagg aataaaaatt     2760

gatgcatatc cgtggttgga atgcttcatc aagtcataca atgtcacaaa tggaacagat     2820

aatcaaattt gctatcagat ttttgacacc acagttgcag aagatgtaat ctaa           2874


<210>  26
<211>  2877
<212>  DNA
<213>  Homo sapiens / NLS-sfGFP-linker 1-cPPR-Telo1-linker 2-POT1(ΔOB)

<400>  26
atggataaag cggaattaat tcccgagcct ccaaaaaaga agagaaaggt cgaattgggt       60

atgggtagca aaggagaaga acttttcact ggagttgtcc caattcttgt tgaattagat      120

ggtgatgtta atgggcacaa attttctgtc cgtggagagg gtgaaggtga tgctacaaac      180

ggaaaactca cccttaaatt tatttgcact actggaaaac tacctgttcc gtggccaaca      240

cttgtcacta ctctgaccta tggtgttcaa tgcttttccc gttatccgga tcacatgaaa      300

cggcatgact ttttcaagag tgccatgccc gaaggttatg tacaggaacg cactatatct      360

ttcaaagatg acgggaccta caagacgcgt gctgaagtca agtttgaagg tgataccctt      420

gttaatcgta tcgagttaaa gggtattgat tttaaagaag atggaaacat tcttggacac      480

aaactcgagt acaactttaa ctcacacaat gtatacatca cggcagacaa acaaaagaat      540

ggaatcaaag ctaacttcaa aattcgccac aacgttgaag atggttccgt tcaactagca      600

gaccattatc aacaaaatac tccaattggc gatggccctg tccttttacc agacaaccat      660

tacctgtcga cacaatctgt cctttcgaaa gatcccaacg aaaagcgtga ccacatggtc      720

cttcttgagt ttgtaactgc tgctgggatt acacatggca tggacgagct gtacaagggt      780

ggtggcgcgc ccatggggaa ttcagtcacc tacaataccc taatctctgg actgggaaag      840

gctggtcgct tagaagaggc tttagaactg ttcgaggaga tgaaagaaaa aggcatagtt      900

cccgatgttg tgacatacaa cacactcatc agtggtcttg gaaaagcagg ccggcttgag      960

gaagctctgg aattgttcga ggaaatgaag gagaagggga tcgtgccgga tgtggttaca     1020

tacacaacgc ttattagcgg cctcggcaag gctggccgtc tggaggaggc gcttgagttg     1080

ttcgaagaga tgaaagagaa aggtatagtt ccgaacgtgg tgacgtatac tacactcatc     1140

tccggtctag gcaaagccgg gagattggag gaagcgctag aactgttcga agaaatgaaa     1200

gagaagggta tagtaccaga cgtagtcaca tataccacgt tgatctctgg cctgggcaaa     1260

gccggtcgtc ttgaagaagc gctggaatta tttgaggaga tgaaggaaaa gggtattgtg     1320

cccgacgttg tgacgtacac aacgttgatc agtggccttg ggaaagcggg acgtctggaa     1380

gaagccctcg aattatttga agaaatgaag gaaaaaggta ttgttccgga tgttgtaact     1440

tacaacacgc tgataagtgg tctgggcaaa gctggacgct tagaggaggc cttagagctc     1500

tttgaggaaa tgaaagaaaa ggggattgtg cctgacgtgg tcacatataa caccctgatt     1560

agtggcttag gcaaagcagg tagactggag gaagcgctgg agctgtttga agagatgaag     1620

gagaaaggga ttgttccaga cgttgttacc tatactacgc tcatttctgg gctgggtaaa     1680

gcaggcaggt tagaagaagc actcgaactc tttgaagaga tgaaggagaa aggtatcgtt     1740

cccaacgtag taacctacac tacgctgata tccggcttag gtaaagccgg tcggctggag     1800

gaagctctcg aactgtttga agaaatgaag gaaaaaggaa ttgttccaga tgttgttaca     1860

tatacgacgt tgataagcgg gctcggtaaa gctggagttg atactggaaa cgctagccca     1920

agctctggat cagtatcatt atacgaggta gaaagatgtc aacagctatc tgctacaata     1980

cttacagatc atcagtattt ggagaggaca ccactatgtg ccattttgaa acaaaaagct     2040

cctcaacaat accgcatccg agcaaaattg aggtcatata agcccagaag actatttcag     2100

tctgttaaac ttcattgccc taaatgtcat ttgctgcaag aagttccaca tgagggcgat     2160

ttggatataa tttttcagga tggtgcaact aaaaccccag atgtcaagct acaaaataca     2220

tcattatatg attcaaaaat ctggaccact aaaaatcaaa aaggacgaaa agtagcagtt     2280

cattttgtga aaaataatgg tattctcccg ctttcaaatg aatgtctact tttgatagaa     2340

ggaggtacac tcagtgaaat ttgcaaactc tcgaacaagt ttaatagtgt aattcctgtg     2400

agatctggcc acgaagacct ggaacttttg gacctttcag caccatttct tatacaagga     2460

acaatacatc actatggatg taaacagtgt tctagtttga gatccataca aaatctaaat     2520

tccctggttg ataaaacatc gtggattcct tcttctgtgg cagaagcact gggtattgta     2580

cccctccaat atgtgtttgt tatgaccttt acacttgatg atggaacagg agtactagaa     2640

gcctatctca tggattctga caaattcttc cagattccag catcagaagt tctgatggat     2700

gatgaccttc agaaaagtgt ggatatgatc atggatatgt tttgtcctcc aggaataaaa     2760

attgatgcat atccgtggtt ggaatgcttc atcaagtcat acaatgtcac aaatggaaca     2820

gataatcaaa tttgctatca gatttttgac accacagttg cagaagatgt aatctaa        2877


<210>  27
<211>  2877
<212>  DNA
<213>  Homo sapiens / NLS-sfGFP-linker 1-cPPR-Telo2-linker 2-POT1(ΔOB)

<400>  27
atggataaag cggaattaat tcccgagcct ccaaaaaaga agagaaaggt cgaattgggt       60

atgggtagca aaggagaaga acttttcact ggagttgtcc caattcttgt tgaattagat      120

ggtgatgtta atgggcacaa attttctgtc cgtggagagg gtgaaggtga tgctacaaac      180

ggaaaactca cccttaaatt tatttgcact actggaaaac tacctgttcc gtggccaaca      240

cttgtcacta ctctgaccta tggtgttcaa tgcttttccc gttatccgga tcacatgaaa      300

cggcatgact ttttcaagag tgccatgccc gaaggttatg tacaggaacg cactatatct      360

ttcaaagatg acgggaccta caagacgcgt gctgaagtca agtttgaagg tgataccctt      420

gttaatcgta tcgagttaaa gggtattgat tttaaagaag atggaaacat tcttggacac      480

aaactcgagt acaactttaa ctcacacaat gtatacatca cggcagacaa acaaaagaat      540

ggaatcaaag ctaacttcaa aattcgccac aacgttgaag atggttccgt tcaactagca      600

gaccattatc aacaaaatac tccaattggc gatggccctg tccttttacc agacaaccat      660

tacctgtcga cacaatctgt cctttcgaaa gatcccaacg aaaagcgtga ccacatggtc      720

cttcttgagt ttgtaactgc tgctgggatt acacatggca tggacgagct gtacaagggt      780

ggtggcgcgc ccatggggaa ttcagtcacc tacactaccc taatctctgg actgggaaag      840

gctggtcgct tagaagaggc tttagaactg ttcgaggaga tgaaagaaaa aggcatagtt      900

cccgatgttg tgacatacac cacactcatc agtggtcttg gaaaagcagg ccggcttgag      960

gaagctctgg aattgttcga ggaaatgaag gagaagggga tcgtgccgga tgtggttaca     1020

tacaacacgc ttattagcgg cctcggcaag gctggccgtc tggaggaggc gcttgagttg     1080

ttcgaagaga tgaaagagaa aggtatagtt ccggacgtgg tgacgtataa tacactcatc     1140

tccggtctag gcaaagccgg gagattggag gaagcgctag aactgttcga agaaatgaaa     1200

gagaagggta tagtaccaga cgtagtcaca tataccacgt tgatctctgg cctgggcaaa     1260

gccggtcgtc ttgaagaagc gctggaatta tttgaggaga tgaaggaaaa gggtattgtg     1320

cccaacgttg tgacgtacac cacgttgatc agtggccttg ggaaagcggg acgtctggaa     1380

gaagccctcg aattatttga agaaatgaag gaaaaaggta ttgttccgga tgttgtaact     1440

tacaccacgc tgataagtgg tctgggcaaa gctggacgct tagaggaggc cttagagctc     1500

tttgaggaaa tgaaagaaaa ggggattgtg cctgacgtgg tcacatatac caccctgatt     1560

agtggcttag gcaaagcagg tagactggag gaagcgctgg agctgtttga agagatgaag     1620

gagaaaggga ttgttccaga cgttgttacc tataatacgc tcatttctgg gctgggtaaa     1680

gcaggcaggt tagaagaagc actcgaactc tttgaagaga tgaaggagaa aggtatcgtt     1740

cccgacgtag taacctacaa tacgctgata tccggcttag gtaaagccgg tcggctggag     1800

gaagctctcg aactgtttga agaaatgaag gaaaaaggaa ttgttccaga tgttgttaca     1860

tatactacgt tgataagcgg gctcggtaaa gctggagttg atactggaaa cgctagccca     1920

agctctggat cagtatcatt atacgaggta gaaagatgtc aacagctatc tgctacaata     1980

cttacagatc atcagtattt ggagaggaca ccactatgtg ccattttgaa acaaaaagct     2040

cctcaacaat accgcatccg agcaaaattg aggtcatata agcccagaag actatttcag     2100

tctgttaaac ttcattgccc taaatgtcat ttgctgcaag aagttccaca tgagggcgat     2160

ttggatataa tttttcagga tggtgcaact aaaaccccag atgtcaagct acaaaataca     2220

tcattatatg attcaaaaat ctggaccact aaaaatcaaa aaggacgaaa agtagcagtt     2280

cattttgtga aaaataatgg tattctcccg ctttcaaatg aatgtctact tttgatagaa     2340

ggaggtacac tcagtgaaat ttgcaaactc tcgaacaagt ttaatagtgt aattcctgtg     2400

agatctggcc acgaagacct ggaacttttg gacctttcag caccatttct tatacaagga     2460

acaatacatc actatggatg taaacagtgt tctagtttga gatccataca aaatctaaat     2520

tccctggttg ataaaacatc gtggattcct tcttctgtgg cagaagcact gggtattgta     2580

cccctccaat atgtgtttgt tatgaccttt acacttgatg atggaacagg agtactagaa     2640

gcctatctca tggattctga caaattcttc cagattccag catcagaagt tctgatggat     2700

gatgaccttc agaaaagtgt ggatatgatc atggatatgt tttgtcctcc aggaataaaa     2760

attgatgcat atccgtggtt ggaatgcttc atcaagtcat acaatgtcac aaatggaaca     2820

gataatcaaa tttgctatca gatttttgac accacagttg cagaagatgt aatctaa        2877


<210>  28
<211>  20
<212>  PRT
<213>  Homo sapiens / Nuclear Localization Signal (NLS)

<400>  28

Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Leu Gly 
            20  


<210>  29
<211>  239
<212>  PRT
<213>  Homo sapiens / Enhanced green fluorescent protein (EGFP)

<400>  29

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  30
<211>  239
<212>  PRT
<213>  Homo sapiens / Superfolder green fluorescent protein (sfGFP)

<400>  30

Met Gly Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  31
<211>  4
<212>  PRT
<213>  Homo sapiens / Linker 1

<400>  31

Gly Gly Ala Pro 
1               


<210>  32
<211>  368
<212>  PRT
<213>  Homo sapiens / cPPR-Telo1

<400>  32

Met Gly Asn Ser Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys 
1               5                   10                  15      


Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu 
            20                  25                  30          


Lys Gly Ile Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly 
        35                  40                  45              


Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu 
    50                  55                  60                  


Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu 
65                  70                  75                  80  


Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu 
                85                  90                  95      


Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asn Val Val Thr Tyr 
            100                 105                 110         


Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala 
        115                 120                 125             


Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val 
    130                 135                 140                 


Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 
145                 150                 155                 160 


Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 
                165                 170                 175     


Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala 
            180                 185                 190         


Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys 
        195                 200                 205             


Gly Ile Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu 
    210                 215                 220                 


Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met 
225                 230                 235                 240 


Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile 
                245                 250                 255     


Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe 
            260                 265                 270         


Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr 
        275                 280                 285             


Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu 
    290                 295                 300                 


Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asn Val Val 
305                 310                 315                 320 


Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu 
                325                 330                 335     


Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro 
            340                 345                 350         


Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 
        355                 360                 365             


<210>  33
<211>  7
<212>  PRT
<213>  Homo sapiens / Linker 2

<400>  33

Val Asp Thr Gly Asn Ala Ser 
1               5           


<210>  34
<211>  319
<212>  PRT
<213>  Homo sapiens / POT1(ΔOB)

<400>  34

Pro Ser Ser Gly Ser Val Ser Leu Tyr Glu Val Glu Arg Cys Gln Gln 
1               5                   10                  15      


Leu Ser Ala Thr Ile Leu Thr Asp His Gln Tyr Leu Glu Arg Thr Pro 
            20                  25                  30          


Leu Cys Ala Ile Leu Lys Gln Lys Ala Pro Gln Gln Tyr Arg Ile Arg 
        35                  40                  45              


Ala Lys Leu Arg Ser Tyr Lys Pro Arg Arg Leu Phe Gln Ser Val Lys 
    50                  55                  60                  


Leu His Cys Pro Lys Cys His Leu Leu Gln Glu Val Pro His Glu Gly 
65                  70                  75                  80  


Asp Leu Asp Ile Ile Phe Gln Asp Gly Ala Thr Lys Thr Pro Asp Val 
                85                  90                  95      


Lys Leu Gln Asn Thr Ser Leu Tyr Asp Ser Lys Ile Trp Thr Thr Lys 
            100                 105                 110         


Asn Gln Lys Gly Arg Lys Val Ala Val His Phe Val Lys Asn Asn Gly 
        115                 120                 125             


Ile Leu Pro Leu Ser Asn Glu Cys Leu Leu Leu Ile Glu Gly Gly Thr 
    130                 135                 140                 


Leu Ser Glu Ile Cys Lys Leu Ser Asn Lys Phe Asn Ser Val Ile Pro 
145                 150                 155                 160 


Val Arg Ser Gly His Glu Asp Leu Glu Leu Leu Asp Leu Ser Ala Pro 
                165                 170                 175     


Phe Leu Ile Gln Gly Thr Ile His His Tyr Gly Cys Lys Gln Cys Ser 
            180                 185                 190         


Ser Leu Arg Ser Ile Gln Asn Leu Asn Ser Leu Val Asp Lys Thr Ser 
        195                 200                 205             


Trp Ile Pro Ser Ser Val Ala Glu Ala Leu Gly Ile Val Pro Leu Gln 
    210                 215                 220                 


Tyr Val Phe Val Met Thr Phe Thr Leu Asp Asp Gly Thr Gly Val Leu 
225                 230                 235                 240 


Glu Ala Tyr Leu Met Asp Ser Asp Lys Phe Phe Gln Ile Pro Ala Ser 
                245                 250                 255     


Glu Val Leu Met Asp Asp Asp Leu Gln Lys Ser Val Asp Met Ile Met 
            260                 265                 270         


Asp Met Phe Cys Pro Pro Gly Ile Lys Ile Asp Ala Tyr Pro Trp Leu 
        275                 280                 285             


Glu Cys Phe Ile Lys Ser Tyr Asn Val Thr Asn Gly Thr Asp Asn Gln 
    290                 295                 300                 


Ile Cys Tyr Gln Ile Phe Asp Thr Thr Val Ala Glu Asp Val Ile 
305                 310                 315                 


<210>  35
<211>  368
<212>  PRT
<213>  Homo sapiens / cPPR-Telo2

<400>  35

Met Gly Asn Ser Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys 
1               5                   10                  15      


Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu 
            20                  25                  30          


Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly 
        35                  40                  45              


Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu 
    50                  55                  60                  


Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Asn Thr Leu 
65                  70                  75                  80  


Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu 
                85                  90                  95      


Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr 
            100                 105                 110         


Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala 
        115                 120                 125             


Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val 
    130                 135                 140                 


Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 
145                 150                 155                 160 


Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 
                165                 170                 175     


Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala 
            180                 185                 190         


Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys 
        195                 200                 205             


Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu 
    210                 215                 220                 


Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met 
225                 230                 235                 240 


Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 
                245                 250                 255     


Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe 
            260                 265                 270         


Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Asn 
        275                 280                 285             


Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu 
    290                 295                 300                 


Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val 
305                 310                 315                 320 


Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu 
                325                 330                 335     


Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro 
            340                 345                 350         


Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly 
        355                 360                 365             


<210>  36
<211>  957
<212>  PRT
<213>  Homo sapiens / NLS-EGFP-linker 1-cPPR-Telo1-linker 2-POT1(ΔOB)

<400>  36

Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Leu Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Gly Gly Ala Pro Met Gly Asn Ser Val Thr Tyr Asn Thr 
            260                 265                 270         


Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu 
        275                 280                 285             


Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr 
    290                 295                 300                 


Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu 
305                 310                 315                 320 


Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp 
                325                 330                 335     


Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
            340                 345                 350         


Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
        355                 360                 365             


Val Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys 
    370                 375                 380                 


Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu 
385                 390                 395                 400 


Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly 
                405                 410                 415     


Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu 
            420                 425                 430         


Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu 
        435                 440                 445             


Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu 
    450                 455                 460                 


Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr 
465                 470                 475                 480 


Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala 
                485                 490                 495     


Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val 
            500                 505                 510         


Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 
        515                 520                 525             


Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 
    530                 535                 540                 


Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala 
545                 550                 555                 560 


Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys 
                565                 570                 575     


Gly Ile Val Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu 
            580                 585                 590         


Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met 
        595                 600                 605             


Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 
    610                 615                 620                 


Ser Gly Leu Gly Lys Ala Gly Val Asp Thr Gly Asn Ala Ser Pro Ser 
625                 630                 635                 640 


Ser Gly Ser Val Ser Leu Tyr Glu Val Glu Arg Cys Gln Gln Leu Ser 
                645                 650                 655     


Ala Thr Ile Leu Thr Asp His Gln Tyr Leu Glu Arg Thr Pro Leu Cys 
            660                 665                 670         


Ala Ile Leu Lys Gln Lys Ala Pro Gln Gln Tyr Arg Ile Arg Ala Lys 
        675                 680                 685             


Leu Arg Ser Tyr Lys Pro Arg Arg Leu Phe Gln Ser Val Lys Leu His 
    690                 695                 700                 


Cys Pro Lys Cys His Leu Leu Gln Glu Val Pro His Glu Gly Asp Leu 
705                 710                 715                 720 


Asp Ile Ile Phe Gln Asp Gly Ala Thr Lys Thr Pro Asp Val Lys Leu 
                725                 730                 735     


Gln Asn Thr Ser Leu Tyr Asp Ser Lys Ile Trp Thr Thr Lys Asn Gln 
            740                 745                 750         


Lys Gly Arg Lys Val Ala Val His Phe Val Lys Asn Asn Gly Ile Leu 
        755                 760                 765             


Pro Leu Ser Asn Glu Cys Leu Leu Leu Ile Glu Gly Gly Thr Leu Ser 
    770                 775                 780                 


Glu Ile Cys Lys Leu Ser Asn Lys Phe Asn Ser Val Ile Pro Val Arg 
785                 790                 795                 800 


Ser Gly His Glu Asp Leu Glu Leu Leu Asp Leu Ser Ala Pro Phe Leu 
                805                 810                 815     


Ile Gln Gly Thr Ile His His Tyr Gly Cys Lys Gln Cys Ser Ser Leu 
            820                 825                 830         


Arg Ser Ile Gln Asn Leu Asn Ser Leu Val Asp Lys Thr Ser Trp Ile 
        835                 840                 845             


Pro Ser Ser Val Ala Glu Ala Leu Gly Ile Val Pro Leu Gln Tyr Val 
    850                 855                 860                 


Phe Val Met Thr Phe Thr Leu Asp Asp Gly Thr Gly Val Leu Glu Ala 
865                 870                 875                 880 


Tyr Leu Met Asp Ser Asp Lys Phe Phe Gln Ile Pro Ala Ser Glu Val 
                885                 890                 895     


Leu Met Asp Asp Asp Leu Gln Lys Ser Val Asp Met Ile Met Asp Met 
            900                 905                 910         


Phe Cys Pro Pro Gly Ile Lys Ile Asp Ala Tyr Pro Trp Leu Glu Cys 
        915                 920                 925             


Phe Ile Lys Ser Tyr Asn Val Thr Asn Gly Thr Asp Asn Gln Ile Cys 
    930                 935                 940                 


Tyr Gln Ile Phe Asp Thr Thr Val Ala Glu Asp Val Ile 
945                 950                 955         


<210>  37
<211>  957
<212>  PRT
<213>  Homo sapiens / NLS-EGFP-linker 1-cPPR-Telo2-linker 2-POT1(ΔOB)

<400>  37

Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Leu Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Gly Gly Ala Pro Met Gly Asn Ser Val Thr Tyr Thr Thr 
            260                 265                 270         


Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu 
        275                 280                 285             


Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr 
    290                 295                 300                 


Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu 
305                 310                 315                 320 


Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp 
                325                 330                 335     


Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
            340                 345                 350         


Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
        355                 360                 365             


Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys 
    370                 375                 380                 


Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu 
385                 390                 395                 400 


Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly 
                405                 410                 415     


Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu 
            420                 425                 430         


Met Lys Glu Lys Gly Ile Val Pro Asn Val Val Thr Tyr Thr Thr Leu 
        435                 440                 445             


Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu 
    450                 455                 460                 


Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr 
465                 470                 475                 480 


Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala 
                485                 490                 495     


Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val 
            500                 505                 510         


Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 
        515                 520                 525             


Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 
    530                 535                 540                 


Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 
545                 550                 555                 560 


Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys 
                565                 570                 575     


Gly Ile Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu 
            580                 585                 590         


Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met 
        595                 600                 605             


Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 
    610                 615                 620                 


Ser Gly Leu Gly Lys Ala Gly Val Asp Thr Gly Asn Ala Ser Pro Ser 
625                 630                 635                 640 


Ser Gly Ser Val Ser Leu Tyr Glu Val Glu Arg Cys Gln Gln Leu Ser 
                645                 650                 655     


Ala Thr Ile Leu Thr Asp His Gln Tyr Leu Glu Arg Thr Pro Leu Cys 
            660                 665                 670         


Ala Ile Leu Lys Gln Lys Ala Pro Gln Gln Tyr Arg Ile Arg Ala Lys 
        675                 680                 685             


Leu Arg Ser Tyr Lys Pro Arg Arg Leu Phe Gln Ser Val Lys Leu His 
    690                 695                 700                 


Cys Pro Lys Cys His Leu Leu Gln Glu Val Pro His Glu Gly Asp Leu 
705                 710                 715                 720 


Asp Ile Ile Phe Gln Asp Gly Ala Thr Lys Thr Pro Asp Val Lys Leu 
                725                 730                 735     


Gln Asn Thr Ser Leu Tyr Asp Ser Lys Ile Trp Thr Thr Lys Asn Gln 
            740                 745                 750         


Lys Gly Arg Lys Val Ala Val His Phe Val Lys Asn Asn Gly Ile Leu 
        755                 760                 765             


Pro Leu Ser Asn Glu Cys Leu Leu Leu Ile Glu Gly Gly Thr Leu Ser 
    770                 775                 780                 


Glu Ile Cys Lys Leu Ser Asn Lys Phe Asn Ser Val Ile Pro Val Arg 
785                 790                 795                 800 


Ser Gly His Glu Asp Leu Glu Leu Leu Asp Leu Ser Ala Pro Phe Leu 
                805                 810                 815     


Ile Gln Gly Thr Ile His His Tyr Gly Cys Lys Gln Cys Ser Ser Leu 
            820                 825                 830         


Arg Ser Ile Gln Asn Leu Asn Ser Leu Val Asp Lys Thr Ser Trp Ile 
        835                 840                 845             


Pro Ser Ser Val Ala Glu Ala Leu Gly Ile Val Pro Leu Gln Tyr Val 
    850                 855                 860                 


Phe Val Met Thr Phe Thr Leu Asp Asp Gly Thr Gly Val Leu Glu Ala 
865                 870                 875                 880 


Tyr Leu Met Asp Ser Asp Lys Phe Phe Gln Ile Pro Ala Ser Glu Val 
                885                 890                 895     


Leu Met Asp Asp Asp Leu Gln Lys Ser Val Asp Met Ile Met Asp Met 
            900                 905                 910         


Phe Cys Pro Pro Gly Ile Lys Ile Asp Ala Tyr Pro Trp Leu Glu Cys 
        915                 920                 925             


Phe Ile Lys Ser Tyr Asn Val Thr Asn Gly Thr Asp Asn Gln Ile Cys 
    930                 935                 940                 


Tyr Gln Ile Phe Asp Thr Thr Val Ala Glu Asp Val Ile 
945                 950                 955         


<210>  38
<211>  957
<212>  PRT
<213>  Homo sapiens / NLS-sfGFP-linker-cPPR-Telo1-linker-POT1(ΔOB)

<400>  38

Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Leu Gly Met Gly Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Val Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Gly Gly Ala Pro Met Gly Asn Ser Val Thr Tyr Asn Thr 
            260                 265                 270         


Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu 
        275                 280                 285             


Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr 
    290                 295                 300                 


Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu 
305                 310                 315                 320 


Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp 
                325                 330                 335     


Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
            340                 345                 350         


Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
        355                 360                 365             


Val Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys 
    370                 375                 380                 


Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu 
385                 390                 395                 400 


Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly 
                405                 410                 415     


Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu 
            420                 425                 430         


Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu 
        435                 440                 445             


Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu 
    450                 455                 460                 


Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr 
465                 470                 475                 480 


Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala 
                485                 490                 495     


Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val 
            500                 505                 510         


Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 
        515                 520                 525             


Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 
    530                 535                 540                 


Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala 
545                 550                 555                 560 


Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys 
                565                 570                 575     


Gly Ile Val Pro Asn Val Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu 
            580                 585                 590         


Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met 
        595                 600                 605             


Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 
    610                 615                 620                 


Ser Gly Leu Gly Lys Ala Gly Val Asp Thr Gly Asn Ala Ser Pro Ser 
625                 630                 635                 640 


Ser Gly Ser Val Ser Leu Tyr Glu Val Glu Arg Cys Gln Gln Leu Ser 
                645                 650                 655     


Ala Thr Ile Leu Thr Asp His Gln Tyr Leu Glu Arg Thr Pro Leu Cys 
            660                 665                 670         


Ala Ile Leu Lys Gln Lys Ala Pro Gln Gln Tyr Arg Ile Arg Ala Lys 
        675                 680                 685             


Leu Arg Ser Tyr Lys Pro Arg Arg Leu Phe Gln Ser Val Lys Leu His 
    690                 695                 700                 


Cys Pro Lys Cys His Leu Leu Gln Glu Val Pro His Glu Gly Asp Leu 
705                 710                 715                 720 


Asp Ile Ile Phe Gln Asp Gly Ala Thr Lys Thr Pro Asp Val Lys Leu 
                725                 730                 735     


Gln Asn Thr Ser Leu Tyr Asp Ser Lys Ile Trp Thr Thr Lys Asn Gln 
            740                 745                 750         


Lys Gly Arg Lys Val Ala Val His Phe Val Lys Asn Asn Gly Ile Leu 
        755                 760                 765             


Pro Leu Ser Asn Glu Cys Leu Leu Leu Ile Glu Gly Gly Thr Leu Ser 
    770                 775                 780                 


Glu Ile Cys Lys Leu Ser Asn Lys Phe Asn Ser Val Ile Pro Val Arg 
785                 790                 795                 800 


Ser Gly His Glu Asp Leu Glu Leu Leu Asp Leu Ser Ala Pro Phe Leu 
                805                 810                 815     


Ile Gln Gly Thr Ile His His Tyr Gly Cys Lys Gln Cys Ser Ser Leu 
            820                 825                 830         


Arg Ser Ile Gln Asn Leu Asn Ser Leu Val Asp Lys Thr Ser Trp Ile 
        835                 840                 845             


Pro Ser Ser Val Ala Glu Ala Leu Gly Ile Val Pro Leu Gln Tyr Val 
    850                 855                 860                 


Phe Val Met Thr Phe Thr Leu Asp Asp Gly Thr Gly Val Leu Glu Ala 
865                 870                 875                 880 


Tyr Leu Met Asp Ser Asp Lys Phe Phe Gln Ile Pro Ala Ser Glu Val 
                885                 890                 895     


Leu Met Asp Asp Asp Leu Gln Lys Ser Val Asp Met Ile Met Asp Met 
            900                 905                 910         


Phe Cys Pro Pro Gly Ile Lys Ile Asp Ala Tyr Pro Trp Leu Glu Cys 
        915                 920                 925             


Phe Ile Lys Ser Tyr Asn Val Thr Asn Gly Thr Asp Asn Gln Ile Cys 
    930                 935                 940                 


Tyr Gln Ile Phe Asp Thr Thr Val Ala Glu Asp Val Ile 
945                 950                 955         


<210>  39
<211>  957
<212>  PRT
<213>  Homo sapiens / NLS- sfGFP-linker 1-cPPR-Telo2-linker 2-POT1(ΔOB)

<400>  39

Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Leu Gly Met Gly Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Val Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Gly Gly Ala Pro Met Gly Asn Ser Val Thr Tyr Thr Thr 
            260                 265                 270         


Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu 
        275                 280                 285             


Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr 
    290                 295                 300                 


Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu 
305                 310                 315                 320 


Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp 
                325                 330                 335     


Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg 
            340                 345                 350         


Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile 
        355                 360                 365             


Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys 
    370                 375                 380                 


Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu 
385                 390                 395                 400 


Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile Ser Gly 
                405                 410                 415     


Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu 
            420                 425                 430         


Met Lys Glu Lys Gly Ile Val Pro Asn Val Val Thr Tyr Thr Thr Leu 
        435                 440                 445             


Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu 
    450                 455                 460                 


Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr 
465                 470                 475                 480 


Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu Glu Glu Ala 
                485                 490                 495     


Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val Pro Asp Val 
            500                 505                 510         


Val Thr Tyr Thr Thr Leu Ile Ser Gly Leu Gly Lys Ala Gly Arg Leu 
        515                 520                 525             


Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys Gly Ile Val 
    530                 535                 540                 


Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu Gly Lys Ala 
545                 550                 555                 560 


Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met Lys Glu Lys 
                565                 570                 575     


Gly Ile Val Pro Asp Val Val Thr Tyr Asn Thr Leu Ile Ser Gly Leu 
            580                 585                 590         


Gly Lys Ala Gly Arg Leu Glu Glu Ala Leu Glu Leu Phe Glu Glu Met 
        595                 600                 605             


Lys Glu Lys Gly Ile Val Pro Asp Val Val Thr Tyr Thr Thr Leu Ile 
    610                 615                 620                 


Ser Gly Leu Gly Lys Ala Gly Val Asp Thr Gly Asn Ala Ser Pro Ser 
625                 630                 635                 640 


Ser Gly Ser Val Ser Leu Tyr Glu Val Glu Arg Cys Gln Gln Leu Ser 
                645                 650                 655     


Ala Thr Ile Leu Thr Asp His Gln Tyr Leu Glu Arg Thr Pro Leu Cys 
            660                 665                 670         


Ala Ile Leu Lys Gln Lys Ala Pro Gln Gln Tyr Arg Ile Arg Ala Lys 
        675                 680                 685             


Leu Arg Ser Tyr Lys Pro Arg Arg Leu Phe Gln Ser Val Lys Leu His 
    690                 695                 700                 


Cys Pro Lys Cys His Leu Leu Gln Glu Val Pro His Glu Gly Asp Leu 
705                 710                 715                 720 


Asp Ile Ile Phe Gln Asp Gly Ala Thr Lys Thr Pro Asp Val Lys Leu 
                725                 730                 735     


Gln Asn Thr Ser Leu Tyr Asp Ser Lys Ile Trp Thr Thr Lys Asn Gln 
            740                 745                 750         


Lys Gly Arg Lys Val Ala Val His Phe Val Lys Asn Asn Gly Ile Leu 
        755                 760                 765             


Pro Leu Ser Asn Glu Cys Leu Leu Leu Ile Glu Gly Gly Thr Leu Ser 
    770                 775                 780                 


Glu Ile Cys Lys Leu Ser Asn Lys Phe Asn Ser Val Ile Pro Val Arg 
785                 790                 795                 800 


Ser Gly His Glu Asp Leu Glu Leu Leu Asp Leu Ser Ala Pro Phe Leu 
                805                 810                 815     


Ile Gln Gly Thr Ile His His Tyr Gly Cys Lys Gln Cys Ser Ser Leu 
            820                 825                 830         


Arg Ser Ile Gln Asn Leu Asn Ser Leu Val Asp Lys Thr Ser Trp Ile 
        835                 840                 845             


Pro Ser Ser Val Ala Glu Ala Leu Gly Ile Val Pro Leu Gln Tyr Val 
    850                 855                 860                 


Phe Val Met Thr Phe Thr Leu Asp Asp Gly Thr Gly Val Leu Glu Ala 
865                 870                 875                 880 


Tyr Leu Met Asp Ser Asp Lys Phe Phe Gln Ile Pro Ala Ser Glu Val 
                885                 890                 895     


Leu Met Asp Asp Asp Leu Gln Lys Ser Val Asp Met Ile Met Asp Met 
            900                 905                 910         


Phe Cys Pro Pro Gly Ile Lys Ile Asp Ala Tyr Pro Trp Leu Glu Cys 
        915                 920                 925             


Phe Ile Lys Ser Tyr Asn Val Thr Asn Gly Thr Asp Asn Gln Ile Cys 
    930                 935                 940                 


Tyr Gln Ile Phe Asp Thr Thr Val Ala Glu Asp Val Ile 
945                 950                 955         
