                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
 
<120>  	IL-13/IL-4 SUPERKINES: IMMUNE CELL TARGETING CONSTRUCTS AND 
       METHODS OF USE THEREOF

<130>  068597-5039-WO

<140>  PCT/US19/35186
<141>  2019-06-03

<150>  US 62/687,225
<151>  2018-06-19

<150>  US 62/679,692
<151>  2018-06-01

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  1

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  2

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  3
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  3

Pro Gly Pro Val Pro Pro Ser Thr Ala Ile Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Ala Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  4

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  5

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Ile Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Ile Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Ala Leu Met Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  6

Pro Gly Pro Val Pro Pro Ser Thr Ala Ile Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Leu Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Met Lys Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Ala Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  7

Pro Gly Pro Val Pro Pro Ser Thr Ala Ile Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  8

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Glu Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Ile Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Tyr His Leu Arg Ala Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  9

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Ser Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Pro Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ala Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Asp Lys Gly Ser Met Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Tyr His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  10

Pro Gly Pro Val Pro Pro Ser Thr Ala Thr Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Asp Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Val Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Tyr His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  11
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  11

Pro Gly Pro Val Pro Pro Ser Thr Ala Asp Ile Glu Leu Ile Ala Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Asp Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Lys Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  12

Pro Gly Pro Val Pro Pro Ser Thr Ala Ala Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Leu 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Lys Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Arg Ala Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  13
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  13

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Asp Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Lys Glu Leu Phe Thr Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  14

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Ser Glu Leu Met Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Asp Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Lys Ala Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  15

Gly Pro Val Pro Pro Ser Thr Ala Phe Arg Glu Leu Ile Glu Glu Leu 
1               5                   10                  15      


Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met 
            20                  25                  30          


Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu 
        35                  40                  45              


Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg 
    50                  55                  60                  


Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Pro Gly Gln Phe Ser 
65                  70                  75                  80  


Ser Leu His Val Thr Asn Ser Arg Ile Glu Val Ala Gln Phe Val Lys 
                85                  90                  95      


Asp Leu Leu Asn His Leu Lys Ala Leu Phe Lys Glu Gly Gln Tyr Asn 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  16

Gly Pro Val Pro Pro Ser Thr Ala His Leu Glu Leu Ile Glu Glu Leu 
1               5                   10                  15      


Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met 
            20                  25                  30          


Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu 
        35                  40                  45              


Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg 
    50                  55                  60                  


Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe Ser 
65                  70                  75                  80  


Ser Leu His Val Lys Glu Thr Arg Ile Glu Val Ala Gln Phe Val Lys 
                85                  90                  95      


Asp Leu Leu Asn His Leu Lys Thr Leu Phe Lys Glu Gly Gln Phe Asn 
            100                 105                 110         


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  17

Pro Gly Pro Val Pro Pro Ser Thr Ala His Leu Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Pro Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Met Asp Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  18

Pro Gly Pro Val Pro Pro Ser Thr Ala His Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Arg Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  19

Pro Gly Pro Val Pro Pro Ser Thr Ala His Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Arg Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Met Asp Ser Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Arg Ala Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  20

Pro Gly Pro Val Pro Pro Ser Thr Ala Ala Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Phe Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Lys 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Pro Ser Leu His Val Lys Lys Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Ile His Leu Arg Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  21

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Ile Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Ala Leu Met Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  22

Pro Gly Pro Val Pro Pro Ser Thr Ala Ile Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Leu Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Met Lys Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Ala Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  23
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  23

Pro Gly Pro Val Pro Pro Ser Thr Ala Ile Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Ala Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  24

Pro Gly Pro Val Pro Pro Ser Thr Ala Ile Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu His His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  25

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  26

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Tyr His Leu Arg Ala Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  27

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Ser Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Gly Ser Met Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Tyr His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  28

Pro Gly Pro Val Pro Pro Ser Thr Ala Thr Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Gly Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Tyr His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  29
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  29

Pro Gly Pro Val Pro Pro Ser Thr Ala Asp Ile Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Lys Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  30
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  30

Pro Gly Pro Val Pro Pro Ser Thr Ala Ala Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Lys Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Arg Ala Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  31
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  31

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Asp Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Lys Glu Leu Phe Thr Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  32
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  32

Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Ser Glu Leu Met Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Asp Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Lys Ala Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  33
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  33

Pro Gly Pro Val Pro Pro Ser Thr Ala His Leu Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Glu Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Lys Thr Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  34
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  34

Pro Gly Pro Val Pro Pro Ser Thr Ala His Leu Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Met Asp Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  35
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  35

Pro Gly Pro Val Pro Pro Ser Thr Ala His Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Arg Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  36
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  36

Pro Gly Pro Val Pro Pro Ser Thr Ala His Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Met Asp Ser Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Asn His Leu Arg Ala Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  37
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  37

Pro Gly Pro Val Pro Pro Ser Thr Ala Ala Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Phe Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Lys Lys Thr Arg Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Ile His Leu Arg Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  38
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  38

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  39
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  39

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala His Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Thr Gly Arg Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  40
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  40

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  41
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  41

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  42
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  42

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  43

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Leu Thr Ala Gly 
        115         


<210>  44
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  44

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Leu Thr Ala Gly 
        115             


<210>  45
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  45

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu Leu Ile Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Arg Thr Ala Gly 
        115         


<210>  46
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  46

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu Leu Ile Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Arg Thr Ala Gly 
        115             


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  47

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu Leu Ile Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Leu Thr Ala Gly 
        115         


<210>  48
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  48

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu Leu Ile Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Leu Thr Ala Gly 
        115             


<210>  49
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  49

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  50
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  50

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  51
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  51

Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu 
1               5                   10                  15      


Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe 
            20                  25                  30          


Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala 
        35                  40                  45              


Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys 
    50                  55                  60                  


Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg 
65                  70                  75                  80  


Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn 
                85                  90                  95      


Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu 
            100                 105                 110         


Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser 
        115                 120                 125             


<210>  52
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  52

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  53
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  53

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  54
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  54

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Arg Gln Phe Tyr Ser His His Glu Lys Asp 
    130                 135                 140                 


Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln 
145                 150                 155                 160 


Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala 
                165                 170                 175     


Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu 
            180                 185                 190         


Asn Phe Leu Glu Arg Leu Arg Val Ile Met Gln Ser Lys Trp Phe Lys 
        195                 200                 205             


Cys Gly Ala Gly Gly Asn Gly Gly His Lys Cys Asp Ile Thr Leu Gln 
    210                 215                 220                 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
225                 230                 235                 240 


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser 
                245                 250         


<210>  55
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 wildtype

<400>  55

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Lys Cys Ser Ser Gly Gly Asn Gly 
                85                  90                  95      


Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
            100                 105                 110         


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
        115                 120                 125             


Ile Phe Ala Ala Ser 
    130             


<210>  56
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  56

Pro Gly Pro Val Pro Pro Ser Thr Ala His Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Thr Gly Arg Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Lys Glu Gly Gln Phe 
            100                 105                 110         


Asn Gly Gly Gly Gly Ser Met Phe Gln Ile Pro Glu Phe Glu Pro Ser 
        115                 120                 125             


Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro 
    130                 135                 140                 


Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser 
                165                 170                 175     


Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser 
            180                 185                 190         


Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro 
        195                 200                 205             


Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala 
    210                 215                 220                 


Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val 
225                 230                 235                 240 


Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala 
                245                 250                 255     


Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp 
            260                 265                 270         


Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
        275                 280                 285     


<210>  57
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  57

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn Gly Gly Gly Gly Ser Met Phe Gln Ile Pro Glu Phe Glu Pro Ser 
        115                 120                 125             


Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro 
    130                 135                 140                 


Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser 
                165                 170                 175     


Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser 
            180                 185                 190         


Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro 
        195                 200                 205             


Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala 
    210                 215                 220                 


Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val 
225                 230                 235                 240 


Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala 
                245                 250                 255     


Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp 
            260                 265                 270         


Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
        275                 280                 285     


<210>  58
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  58

Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu 
1               5                   10                  15      


Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe 
            20                  25                  30          


Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala 
        35                  40                  45              


Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys 
    50                  55                  60                  


Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg 
65                  70                  75                  80  


Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn 
                85                  90                  95      


Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu 
            100                 105                 110         


Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu 
    130                 135                 140                 


Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala 
145                 150                 155                 160 


Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala Pro Gly 
                165                 170                 175     


Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser 
            180                 185                 190         


His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser Ala 
        195                 200                 205             


Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser 
    210                 215                 220                 


Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala 
225                 230                 235                 240 


Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp 
                245                 250                 255     


Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr 
            260                 265                 270         


Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp 
        275                 280                 285             


Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300     


<210>  59
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  59

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His 
    290                 295                 300                 


His His His His His 
305                 


<210>  60
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  60

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300             


<210>  61
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  61

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300             


<210>  62
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  62

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His 
    290                 295                 300                 


His His His His His 
305                 


<210>  63
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  63

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser Ser 
    130                 135                 140                 


Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser Gly 
145                 150                 155                 160 


Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala Ser 
                165                 170                 175     


His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala Gly 
            180                 185                 190         


Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro Ala Gly Thr Glu 
        195                 200                 205             


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
    210                 215                 220                 


Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu 
225                 230                 235                 240 


Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu 
                245                 250                 255     


Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser Ser 
            260                 265                 270         


Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg 
        275                 280                 285             


Gly Ser Ser Ala Pro Ser Gln 
    290                 295 


<210>  64
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  64

Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu 
1               5                   10                  15      


Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe 
            20                  25                  30          


Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala 
        35                  40                  45              


Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys 
    50                  55                  60                  


Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg 
65                  70                  75                  80  


Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn 
                85                  90                  95      


Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu 
            100                 105                 110         


Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp 
    130                 135                 140                 


Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe 
145                 150                 155                 160 


Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser 
                165                 170                 175     


Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu 
            180                 185                 190         


Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu 
        195                 200                 205             


Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg 
    210                 215                 220                 


Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp 
225                 230                 235                 240 


Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe 
                245                 250                 255     


Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg 
            260                 265                 270         


Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val 
        275                 280                 285             


Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala 
    290                 295                 300                 


Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly 
305                 310                 315                 320 


Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser 
                325                 330                 335     


Arg Lys Gly Gln Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr 
            340                 345                 350         


Val Ala Gly Val Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
        355                 360                 365     


<210>  65
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  65

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Leu Arg Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser 
    130                 135                 140                 


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
145                 150                 155                 160 


Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys 
                165                 170                 175     


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
            180                 185                 190         


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
        195                 200                 205             


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
    210                 215                 220                 


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
225                 230                 235                 240 


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala 
                245                 250                 255     


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
            260                 265                 270         


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
        275                 280                 285             


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
    290                 295                 300                 


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
305                 310                 315                 320 


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
                325                 330                 335     


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
            340                 345                 350         


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
        355                 360                 365             


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
    370                 375                 380                 


Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
385                 390                 395                 400 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
                405                 410                 415     


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
            420                 425                 430         


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
        435                 440                 445             


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
    450                 455                 460                 


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
465                 470                 475                 480 


Pro Lys Asp Glu Leu 
                485 


<210>  66
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  66

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His 
    290                 295                 300                 


His His His His His 
305                 


<210>  67
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  67

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300             


<210>  68
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  68

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu 
    130                 135                 140                 


Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp 
145                 150                 155                 160 


Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu 
                165                 170                 175     


Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His 
            180                 185                 190         


Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro 
        195                 200                 205             


Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe 
    210                 215                 220                 


Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg 
225                 230                 235                 240 


Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe 
                245                 250                 255     


Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met 
            260                 265                 270         


Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg 
        275                 280                 285             


Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His His His His His 
    290                 295                 300                 


His 
305 


<210>  69
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytokine Fusion

<400>  69

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu 
    130                 135                 140                 


Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp 
145                 150                 155                 160 


Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu 
                165                 170                 175     


Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His 
            180                 185                 190         


Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro 
        195                 200                 205             


Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe 
    210                 215                 220                 


Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg 
225                 230                 235                 240 


Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe 
                245                 250                 255     


Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met 
            260                 265                 270         


Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg 
        275                 280                 285             


Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 


<210>  70
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4

<400>  70
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt cc                         402


<210>  71
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpKFR

<400>  71
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gc                         402


<210>  72
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpS4

<400>  72
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt cc                         402


<210>  73
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant BAD

<400>  73
ggtagctttc agatcccgga atttgagccg agcgagcaag aggattcaag cagcgcggag       60

cgcggtctgg gtccgagccc ggcaggcgac ggtccgagcg gcagcggcaa gcatcaccgc      120

caggcgccag gcctgctgtg ggatgcatcg catcaacagg aacaaccgac gagcagcagc      180

catcatggtg gcgctggtgc ggttgagatt agatcgcgcc actccgcata tcctgccggc      240

accgaagatg acgaaggcat gggcgaggaa ccgagcccgt tccgtggccg tagccgtgct      300

gcaccgccga atctgtgggc cgcacagcgt tatggtcgcg agttgcgtcg catgtccgac      360

gagtttgttg actccttcaa gaaaggttta ccgcgtccga aatctgccgg taccgcgacg      420

cagatgcgtc agagcagcag ctggacccgc gtgtttcaat cttggtggga tcgtaatctg      480

ggtcgtggta gcagcgcacc gagccaa                                          507


<210>  74
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-4-Bad fusion

<400>  74
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc ggtagctttc agatcccgga atttgagccg      420

agcgagcaag aggattcaag cagcgcggag cgcggtctgg gtccgagccc ggcaggcgac      480

ggtccgagcg gcagcggcaa gcatcaccgc caggcgccag gcctgctgtg ggatgcatcg      540

catcaacagg aacaaccgac gagcagcagc catcatggtg gcgctggtgc ggttgagatt      600

agatcgcgcc actccgcata tcctgccggc accgaagatg acgaaggcat gggcgaggaa      660

ccgagcccgt tccgtggccg tagccgtgct gcaccgccga atctgtgggc cgcacagcgt      720

tatggtcgcg agttgcgtcg catgtccgac gagtttgttg actccttcaa gaaaggttta      780

ccgcgtccga aatctgccgg taccgcgacg cagatgcgtc agagcagcag ctggacccgc      840

gtgtttcaat cttggtggga tcgtaatctg ggtcgtggta gcagcgcacc gagccaa         897


<210>  75
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4-Bad fusion

<400>  75
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaa                                                              909


<210>  76
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpKFR4-Bad fusion

<400>  76
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gcggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaa                                                              909


<210>  77
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpS4-Bad fusion

<400>  77
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaa                                                              909


<210>  78
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL-4-Bad

<400>  78
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc ggtagctttc agatcccgga atttgagccg      420

agcgagcaag aggattcaag cagcgcggag cgcggtctgg gtccgagccc ggcaggcgac      480

ggtccgagcg gcagcggcaa gcatcaccgc caggcgccag gcctgctgtg ggatgcatcg      540

catcaacagg aacaaccgac gagcagcagc catcatggtg gcgctggtgc ggttgagatt      600

agatcgcgcc actccgcata tcctgccggc accgaagatg acgaaggcat gggcgaggaa      660

ccgagcccgt tccgtggccg tagccgtgct gcaccgccga atctgtgggc cgcacagcgt      720

tatggtcgcg agttgcgtcg catgtccgac gagtttgttg actccttcaa gaaaggttta      780

ccgcgtccga aatctgccgg taccgcgacg cagatgcgtc agagcagcag ctggacccgc      840

gtgtttcaat cttggtggga tcgtaatctg ggtcgtggta gcagcgcacc gagccaacac      900

caccatcacc atcactaa                                                    918


<210>  79
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bp cpIL-4-Bad

<400>  79
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaac accaccatca ccatcac                                          927


<210>  80
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bp cpS4-Bad

<400>  80
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaac accaccatca ccatcactaa                                       930


<210>  81
<211>  926
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bp pKFR4-Bad-H6

<400>  81
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gcggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaac accaccatca ccatca                                           926


<210>  82
<211>  1483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-13DN

<400>  82
tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc       60

ggatctatgc tactagtaaa tcagtcacac caaggcttca ataaggaaca cacaagcaag      120

atggtaagcg ctattgtttt atatgtgctt ttggcggcgg cggcgcattc tgcctttgcg      180

ggatccgcgc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      240

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      300

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      360

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      420

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      480

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      540

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      600

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      660

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      720

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      780

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      840

ctctccctgt ctccgggtaa aggaggcgga agcggatccc caggccctgt gcctccctct      900

acagccgttc gtgcgctcat tgaggagctg attaacatca cccagaacca gaaggctccg      960

ctctgcaatg gcagcatggt atggagcatc aaccggacag ctggcatgta ctgtgcagcc     1020

ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca ggacatgctg     1080

agcggattct gcccgcacaa ggtctcagct gggcagtttt ccagcttgca tgtcaggagt     1140

agtaagatcg aggtggccca gtttgtaaag gacctgctct tccatttaag gactcttttt     1200

agggagggac agttcaacgc ggccgcccat catcaccacc atcaccacca ttaatgaaga     1260

tctgatcctt tcctgggacc cggcaagaac caaaaactca ctctcttcaa ggaaatccgt     1320

aatgttaaac ccgacacgat gaagcttgtc gttggatgga aaggaaaaga gttctacagg     1380

gaaacttgga cccgcttcat ggaagacagc ttccccattg ttaacgacca agaagtgatg     1440

gatgttttcc ttgttgtcaa catgcgtccc actagaccca acc                       1483


<210>  83
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-4

<400>  83
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc                                       390


<210>  84
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAD amino acid

<400>  84

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  85
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bcl-2 amino acid

<400>  85

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  86
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HsBAD_Q92934-1

<400>  86

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  87
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HsBAX_Q07812-1

<400>  87

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 


Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     


Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         


<210>  88
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HsBAK1_Q16611-1

<400>  88

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  89
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HsBIK_Q13323-1

<400>  89

Met Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu 
1               5                   10                  15      


Leu Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met 
            20                  25                  30          


Thr Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu 
        35                  40                  45              


Glu Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile 
    50                  55                  60                  


Gly Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu 
65                  70                  75                  80  


Ser Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln 
                85                  90                  95      


Thr Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr 
            100                 105                 110         


Thr Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly 
        115                 120                 125             


Ser Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Ala Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 160 


<210>  90
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HsBID_P55957-1

<400>  90

Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu 
65                  70                  75                  80  


Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser 
                85                  90                  95      


Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
            100                 105                 110         


Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
        115                 120                 125             


Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
    130                 135                 140                 


Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
                165                 170                 175     


Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn 
            180                 185                 190         


Gly Met Asp 
        195 


<210>  91
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  91

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  92
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  92

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Asn Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  93
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  93

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  94
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  94

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Ala Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  95
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  95

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Ala Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  96
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  96

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Arg Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  97
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  97

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Arg Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Val Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  98
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  98

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Arg Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Ile Pro Arg Asp Val Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  99
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  99

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala His Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Thr Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Ile Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  100
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  100

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Asn Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Val Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  101
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  101

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Val Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  102
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  102

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


His Leu Glu Glu Val Leu Asn Leu Ala Asn Ser Lys Asn Phe His Val 
65                  70                  75                  80  


Thr Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  103
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  103

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala His Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  104
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  104

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  105
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  105

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Asn Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  106
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  106

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Thr Pro Arg Asp Val Ile Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  107
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  107

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  108
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 agonist H9D10

<400>  108

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala His Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  109
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 agonist H9E10

<400>  109

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  110
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 agonist H9G8

<400>  110

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Asn Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  111
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 agonist H9B1

<400>  111

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Asn Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Val Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  112
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  112

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Val Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  113
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  113

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  114
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  114

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Asp Pro Arg Asp Val Ile Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  115
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 wildtype

<400>  115

Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
    50                  55                  60                  


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
65                  70                  75                  80  


Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe Val 
                85                  90                  95      


Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln Phe 
            100                 105                 110         


Asn 
    


<210>  116
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Mutein

<400>  116

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Ser Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Asp Pro Arg Asp Val Ile Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  117

Gly Gly Gly Gly Ser 
1               5   


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  118

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  119

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  120
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  120

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  121
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  121

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


