
                                SEQUENCE LISTING

<110> GlaxoSmithKline Intellectual Property Development Limited

<120> Combination Therapy
  

<130> PU66573

<150> 62/678398           
<151> 2018-05-31  

<160> 18

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Homo Sapien

<400> 1
Asp Tyr Ala Met His
 1               5  


<210> 2
<211> 17
<212> PRT
<213> Homo Sapien

<400> 2
Leu Ile Ser Ile Tyr Ser Asp His Thr Asn Tyr Asn Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    


<210> 3
<211> 12
<212> PRT
<213> Homo Sapien

<400> 3
Asn Asn Tyr Gly Asn Tyr Gly Trp Tyr Phe Asp Val
 1               5                  10          


<210> 4
<211> 10
<212> PRT
<213> Homo Sapien

<400> 4
Ser Ala Ser Ser Ser Val Ser Tyr Met His
 1               5                  10  


<210> 5
<211> 7
<212> PRT
<213> Homo Sapien

<400> 5
Asp Thr Ser Lys Leu Ala Ser
 1               5          


<210> 6
<211> 9
<212> PRT
<213> Homo Sapien

<400> 6
Phe Gln Gly Ser Gly Tyr Pro Tyr Thr
 1               5                  


<210> 7
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino Acid Sequence

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Ser Ile Tyr Ser Asp His Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Asn Asn Tyr Gly Asn Tyr Gly Trp Tyr Phe Asp Val Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 8
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino Acid Sequence

<400> 8
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Tyr Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105     


<210> 9
<211> 168
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of human ICOS isoform 2

<400> 9
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys
 1               5                  10                  15      
Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile
            20                  25                  30          
Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val
        35                  40                  45              
Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp
    50                  55                  60                  
Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu
65                  70                  75                  80  
Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
                85                  90                  95      
Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser
            100                 105                 110         
Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu
        115                 120                 125             
His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro
    130                 135                 140                 
Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu
145                 150                 155                 160 
Ile Cys Trp Leu Thr Lys Lys Met
                165             


<210> 10
<211> 199
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of human ICOS isoform 1

<400> 10
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys
 1               5                  10                  15      
Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile
            20                  25                  30          
Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val
        35                  40                  45              
Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp
    50                  55                  60                  
Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu
65                  70                  75                  80  
Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
                85                  90                  95      
Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser
            100                 105                 110         
Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu
        115                 120                 125             
His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro
    130                 135                 140                 
Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu
145                 150                 155                 160 
Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro
                165                 170                 175     
Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser
            180                 185                 190         
Arg Leu Thr Asp Val Thr Leu
        195                 


<210> 11
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Leu Val Gln Pro Gly Gly Ser
 1               5                  10                  15      
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Trp
            20                  25                  30          
Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Ser
        35                  40                  45              
Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr
                85                  90                  95      
Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 12
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 12
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly
            20                  25                  30          
Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg His Thr Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr
                85                  90                  95      
Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
            100                 105                 110     


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 13
Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp
 1               5                  10  


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 14
Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys
 1               5                  10                  15      
Gly
    


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 15
Trp Gly Arg Phe Gly Phe Asp Ser
 1               5              


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 16
Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr
 1               5                  10                  15  


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 17
Tyr Ala Ser Thr Arg His Thr
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence of 37A10S713

<400> 18
His His His Tyr Asn Ala Pro Pro Thr
 1               5                  

