               SEQUENCE LISTING

<110> B.R.A.H.M.S GmbH 

<120> Biomarkers for the diagnosis of invasive fungal infections

<130> AB1172 PCT BLN

<150> EP 18 17 5538.0

<151> 2018-06-01

<160> 29

<170> BiSSAP 1.3.6

<210> 1
<211> 532
<212> PRT
<213> Homo sapiens


<220> 
<223> Intercellular adhesion molecule 1 (ICAM1)

<400> 1
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 
Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             
Ala Thr Pro Pro 
    530         

<210> 2
<211> 367
<212> PRT
<213> Homo sapiens


<220> 
<223> Alpha-2-HS-glycoprotein (AHSG)

<400> 2
Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      
His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          
Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              
Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  
Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  
Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      
Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         
Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             
Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 
Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 
Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     
Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         
Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             
Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 
Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 
Ala Glu Val Ala Val Thr Cys Thr Val Phe Gln Thr Gln Pro Val Thr 
                245                 250                 255     
Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         
Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             
Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 
Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 
Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     
Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         
Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         

<210> 3
<211> 458
<212> PRT
<213> Homo sapiens


<220> 
<223> Carboxypeptidase N catalytic chain (CPN1)

<400> 3
Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu Phe Lys 
1               5                   10                  15      
Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val 
            20                  25                  30          
Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val 
        35                  40                  45              
Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu 
    50                  55                  60                  
Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys 
65                  70                  75                  80  
Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 
                85                  90                  95      
Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 
            100                 105                 110         
Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 
        115                 120                 125             
Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys 
    130                 135                 140                 
Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn 
145                 150                 155                 160 
Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr 
                165                 170                 175     
Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln 
            180                 185                 190         
Val Glu Pro Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn 
        195                 200                 205             
Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr 
    210                 215                 220                 
Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr 
225                 230                 235                 240 
Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys 
                245                 250                 255     
Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly 
            260                 265                 270         
Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu 
        275                 280                 285             
Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu 
    290                 295                 300                 
Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu 
305                 310                 315                 320 
Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu 
                325                 330                 335     
Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn 
            340                 345                 350         
Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val 
        355                 360                 365             
Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile 
    370                 375                 380                 
Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr 
385                 390                 395                 400 
Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
                405                 410                 415     
Arg Ser Ile Pro Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg 
            420                 425                 430         
His Gly Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met 
        435                 440                 445             
Glu Met Arg Gln Leu Gln Arg Gly Pro Ala 
    450                 455             

<210> 4
<211> 127
<212> PRT
<213> Homo sapiens


<220> 
<223> Fatty acid-binding protein (FABP1)

<400> 4
Met Ser Phe Ser Gly Lys Tyr Gln Leu Gln Ser Gln Glu Asn Phe Glu 
1               5                   10                  15      
Ala Phe Met Lys Ala Ile Gly Leu Pro Glu Glu Leu Ile Gln Lys Gly 
            20                  25                  30          
Lys Asp Ile Lys Gly Val Ser Glu Ile Val Gln Asn Gly Lys His Phe 
        35                  40                  45              
Lys Phe Thr Ile Thr Ala Gly Ser Lys Val Ile Gln Asn Glu Phe Thr 
    50                  55                  60                  
Val Gly Glu Glu Cys Glu Leu Glu Thr Met Thr Gly Glu Lys Val Lys 
65                  70                  75                  80  
Thr Val Val Gln Leu Glu Gly Asp Asn Lys Leu Val Thr Thr Phe Lys 
                85                  90                  95      
Asn Ile Lys Ser Val Thr Glu Leu Asn Gly Asp Ile Ile Thr Asn Thr 
            100                 105                 110         
Met Thr Leu Gly Asp Ile Val Phe Lys Arg Ile Ser Lys Arg Ile 
        115                 120                 125         

<210> 5
<211> 525
<212> PRT
<213> Homo sapiens


<220> 
<223> Histidine-rich glycoprotein (HRG)

<400> 5
Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      
Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          
Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              
Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  
Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  
Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      
Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         
Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             
Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 
Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 
Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     
Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         
Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             
Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 
Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 
Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     
Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         
Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             
Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 
Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 
Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     
Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         
Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             
His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 
His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 
Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     
Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         
Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             
Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 
Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 
Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     
Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         
Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 

<210> 6
<211> 764
<212> PRT
<213> Homo sapiens


<220> 
<223> Polymeric immunoglobulin receptor (PIGR)

<400> 6
Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile 
1               5                   10                  15      
Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu 
            20                  25                  30          
Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn 
        35                  40                  45              
Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys 
    50                  55                  60                  
Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly 
65                  70                  75                  80  
Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn 
                85                  90                  95      
Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu 
            100                 105                 110         
Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser 
        115                 120                 125             
Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu 
    130                 135                 140                 
Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln 
145                 150                 155                 160 
Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val 
                165                 170                 175     
Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg 
            180                 185                 190         
Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn 
        195                 200                 205             
Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp 
    210                 215                 220                 
Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro 
225                 230                 235                 240 
Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His 
                245                 250                 255     
Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg 
            260                 265                 270         
Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys 
        275                 280                 285             
Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys 
    290                 295                 300                 
Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala 
305                 310                 315                 320 
Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly 
                325                 330                 335     
Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile 
            340                 345                 350         
Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala 
        355                 360                 365             
Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp 
    370                 375                 380                 
Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp 
385                 390                 395                 400 
Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu 
                405                 410                 415     
Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr 
            420                 425                 430         
Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu 
        435                 440                 445             
Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu 
    450                 455                 460                 
Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val 
465                 470                 475                 480 
Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys 
                485                 490                 495     
Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly 
            500                 505                 510         
Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser 
        515                 520                 525             
Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys 
    530                 535                 540                 
Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val 
545                 550                 555                 560 
Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala 
                565                 570                 575     
Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg 
            580                 585                 590         
Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu 
        595                 600                 605             
Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser 
    610                 615                 620                 
Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Ala Leu 
625                 630                 635                 640 
Val Ser Thr Leu Val Pro Leu Gly Leu Val Leu Ala Val Gly Ala Val 
                645                 650                 655     
Ala Val Gly Val Ala Arg Ala Arg His Arg Lys Asn Val Asp Arg Val 
            660                 665                 670         
Ser Ile Arg Ser Tyr Arg Thr Asp Ile Ser Met Ser Asp Phe Glu Asn 
        675                 680                 685             
Ser Arg Glu Phe Gly Ala Asn Asp Asn Met Gly Ala Ser Ser Ile Thr 
    690                 695                 700                 
Gln Glu Thr Ser Leu Gly Gly Lys Glu Glu Phe Val Ala Thr Thr Glu 
705                 710                 715                 720 
Ser Thr Thr Glu Thr Lys Glu Pro Lys Lys Ala Lys Arg Ser Ser Lys 
                725                 730                 735     
Glu Glu Ala Glu Met Ala Tyr Lys Asp Phe Leu Leu Gln Ser Ser Thr 
            740                 745                 750         
Val Ala Ala Glu Ala Gln Asp Gly Pro Gln Glu Ala 
        755                 760                 

<210> 7
<211> 184
<212> PRT
<213> Homo sapiens


<220> 
<223> Ras-related protein Rap-1A

<400> 7
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15      
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Cys 
        35                  40                  45              
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60                  
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80  
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95      
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Glu Asp Val Pro Met Ile 
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125             
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Cys Asn Cys Ala Phe Leu 
    130                 135                 140                 
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160 
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Glu Lys Lys Lys Pro 
                165                 170                 175     
Lys Lys Lys Ser Cys Leu Leu Leu 
            180                 

<210> 8
<211> 184
<212> PRT
<213> Homo sapiens


<220> 
<223> Ras-related protein Rap-1b (RAP1B)

<400> 8
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15      
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala 
        35                  40                  45              
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60                  
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80  
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95      
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125             
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu 
    130                 135                 140                 
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160 
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg 
                165                 170                 175     
Lys Lys Ser Ser Cys Gln Leu Leu 
            180                 

<210> 9
<211> 184
<212> PRT
<213> Homo sapiens


<220> 
<223> Ras-related protein Rap-1b-like protein (RP1BL)

<400> 9
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Arg Gly Val Gly Lys 
1               5                   10                  15      
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Glu Gln Val Glu Val Asp Ala 
        35                  40                  45              
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60                  
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80  
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95      
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125             
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu 
    130                 135                 140                 
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160 
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg 
                165                 170                 175     
Lys Lys Ser Ser Cys Gln Leu Leu 
            180                 

<210> 10
<211> 1170
<212> PRT
<213> Homo sapiens


<220> 
<223> Thrombospondin-1 (THBS1)

<400> 10
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      
Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          
Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              
Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  
Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  
Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      
Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         
Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             
Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 
Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 
Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     
Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         
Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             
Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 
Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 
Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     
Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         
Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             
Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 
Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 
Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     
Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         
Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             
Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 
Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 
Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     
Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         
Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             
Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 
Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 
Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     
Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         
Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             
Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 
Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 
Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     
Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         
Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             
Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 
Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 
Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     
Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         
Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             
Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 
Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 
Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     
Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         
Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             
Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 
Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 
Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     
Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         
Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             
Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 
Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 
Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     
Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         
Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             
Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 
Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 
Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     
Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         
Asp Pro Gly Leu Ala Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe 
        995                 1000                1005            
Ser Gly Thr Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly 
    1010                1015                1020                
Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp 
1025                1030                1035                1040
Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln 
                1045                1050                1055    
Gly Tyr Ser Gly Leu Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro 
            1060                1065                1070        
Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly 
        1075                1080                1085            
Gln Val Arg Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp 
    1090                1095                1100                
Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe 
1105                1110                1115                1120
Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile Met Ala Asp Ser Gly 
                1125                1130                1135    
Pro Ile Tyr Asp Lys Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val 
            1140                1145                1150        
Phe Ser Gln Glu Met Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg 
        1155                1160                1165            
Asp Pro 
    1170

<210> 11
<211> 1085
<212> PRT
<213> Homo sapiens


<220> 
<223> Thrombospondin-1(THBS1)

<400> 11
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      
Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His Ser Gly Gln Val Phe 
            20                  25                  30          
Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu Asp Leu Ser Leu Thr 
        35                  40                  45              
Val Gln Gly Lys Gln His Val Val Ser Val Glu Glu Ala Leu Leu Ala 
    50                  55                  60                  
Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val Gln Glu Asp Arg Ala 
65                  70                  75                  80  
Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn Ala Glu Leu Asp Val 
                85                  90                  95      
Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala Ser Ile Ala Arg Leu 
            100                 105                 110         
Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe Gln Gly Val Leu Gln 
        115                 120                 125             
Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu Asp Ile Leu Arg Asn 
    130                 135                 140                 
Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu Thr Leu Asp Asn Asn 
145                 150                 155                 160 
Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr Asn Tyr Ile Gly His 
                165                 170                 175     
Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile Ser Cys Asp Glu Leu 
            180                 185                 190         
Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Ile Val Thr Thr 
        195                 200                 205             
Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu Asn Lys Glu Leu Ala 
    210                 215                 220                 
Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His Asn Gly Val Gln Tyr 
225                 230                 235                 240 
Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys Thr Glu Cys His Cys 
                245                 250                 255     
Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser Cys Pro Ile Met Pro 
            260                 265                 270         
Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys Cys Pro Arg Cys Trp 
        275                 280                 285             
Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro Trp Ser Glu Trp Thr 
    290                 295                 300                 
Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln Gln Arg Gly Arg Ser 
305                 310                 315                 320 
Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser Ser Val Gln Thr Arg 
                325                 330                 335     
Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe Lys Gln Asp Gly Gly 
            340                 345                 350         
Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser Val Thr Cys Gly Asp 
        355                 360                 365             
Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser Pro Ser Pro Gln Met 
    370                 375                 380                 
Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu Thr Lys Ala Cys Lys 
385                 390                 395                 400 
Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly Pro Trp Ser Pro Trp 
                405                 410                 415     
Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val Gln Lys Arg Ser Arg 
            420                 425                 430         
Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly Lys Asp Cys Val Gly 
        435                 440                 445             
Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln Asp Cys Pro Ile Asp 
    450                 455                 460                 
Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val Lys Cys Thr Ser Tyr 
465                 470                 475                 480 
Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro Pro Gly Tyr Ser Gly 
                485                 490                 495     
Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys Lys Glu Val Pro Asp 
            500                 505                 510         
Ala Cys Phe Asn His Asn Gly Glu His Arg Cys Glu Asn Thr Asp Pro 
        515                 520                 525             
Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe Thr Gly Ser Gln Pro 
    530                 535                 540                 
Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn Lys Gln Val Cys Lys 
545                 550                 555                 560 
Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp Cys Asn Lys Asn Ala 
                565                 570                 575     
Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro Met Tyr Arg Cys Glu 
            580                 585                 590         
Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile Cys Gly Glu Asp Thr 
        595                 600                 605             
Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val Cys Val Ala Asn Ala 
    610                 615                 620                 
Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn Leu Pro Asn Ser Gly 
625                 630                 635                 640 
Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp Ala Cys Asp Asp Asp 
                645                 650                 655     
Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp Asn Cys Pro Phe His 
            660                 665                 670         
Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp Asp Val Gly Asp Arg 
        675                 680                 685             
Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp Gln Ala Asp Thr Asp 
    690                 695                 700                 
Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp Ile Asp Gly Asp Gly 
705                 710                 715                 720 
Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val Tyr Asn Val Asp Gln 
                725                 730                 735     
Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln Cys Asp Asn Cys Pro 
            740                 745                 750         
Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp Ser Asp Arg Ile Gly 
        755                 760                 765             
Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu Asp Gly His Gln Asn 
    770                 775                 780                 
Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala Asn Gln Ala Asp His 
785                 790                 795                 800 
Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His Asp Asp Asp Asn Asp 
                805                 810                 815     
Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu Val Pro Asn Pro Asp 
            820                 825                 830         
Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp Ala Cys Lys Asp Asp 
        835                 840                 845             
Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp Ile Cys Pro Glu Asn 
    850                 855                 860                 
Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe Gln Met Ile Pro Leu 
865                 870                 875                 880 
Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn Trp Val Val Arg His 
                885                 890                 895     
Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys Asp Pro Gly Leu Ala 
            900                 905                 910         
Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe Ser Gly Thr Phe Phe 
        915                 920                 925             
Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly Phe Val Phe Gly Tyr 
    930                 935                 940                 
Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp Lys Gln Val Thr Gln 
945                 950                 955                 960 
Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln Gly Tyr Ser Gly Leu 
                965                 970                 975     
Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro Gly Glu His Leu Arg 
            980                 985                 990         
Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly Gln Val Arg Thr Leu 
        995                 1000                1005            
Trp His Asp Pro Arg His Ile Gly Trp Lys Asp Phe Thr Ala Tyr Arg 
    1010                1015                1020                
Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe Ile Arg Val Val Met 
1025                1030                1035                1040
Tyr Glu Gly Lys Lys Ile Met Ala Asp Ser Gly Pro Ile Tyr Asp Lys 
                1045                1050                1055    
Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val Phe Ser Gln Glu Met 
            1060                1065                1070        
Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg Asp Pro 
        1075                1080                1085

<210> 12
<211> 1066
<212> PRT
<213> Homo sapiens


<220> 
<223> Vinculin (VCL)

<400> 12
Met Pro Val Phe His Thr Arg Thr Ile Glu Ser Ile Leu Glu Pro Val 
1               5                   10                  15      
Ala Gln Gln Ile Ser His Leu Val Ile Met His Glu Glu Gly Glu Val 
            20                  25                  30          
Asp Gly Lys Ala Ile Pro Asp Leu Thr Ala Pro Val Ala Ala Val Gln 
        35                  40                  45              
Ala Ala Val Ser Asn Leu Val Arg Val Gly Lys Glu Thr Val Gln Thr 
    50                  55                  60                  
Thr Glu Asp Gln Ile Leu Lys Arg Asp Met Pro Pro Ala Phe Ile Lys 
65                  70                  75                  80  
Val Glu Asn Ala Cys Thr Lys Leu Val Gln Ala Ala Gln Met Leu Gln 
                85                  90                  95      
Ser Asp Pro Tyr Ser Val Pro Ala Arg Asp Tyr Leu Ile Asp Gly Ser 
            100                 105                 110         
Arg Gly Ile Leu Ser Gly Thr Ser Asp Leu Leu Leu Thr Phe Asp Glu 
        115                 120                 125             
Ala Glu Val Arg Lys Ile Ile Arg Val Cys Lys Gly Ile Leu Glu Tyr 
    130                 135                 140                 
Leu Thr Val Ala Glu Val Val Glu Thr Met Glu Asp Leu Val Thr Tyr 
145                 150                 155                 160 
Thr Lys Asn Leu Gly Pro Gly Met Thr Lys Met Ala Lys Met Ile Asp 
                165                 170                 175     
Glu Arg Gln Gln Glu Leu Thr His Gln Glu His Arg Val Met Leu Val 
            180                 185                 190         
Asn Ser Met Asn Thr Val Lys Glu Leu Leu Pro Val Leu Ile Ser Ala 
        195                 200                 205             
Met Lys Ile Phe Val Thr Thr Lys Asn Ser Lys Asn Gln Gly Ile Glu 
    210                 215                 220                 
Glu Ala Leu Lys Asn Arg Asn Phe Thr Val Glu Lys Met Ser Ala Glu 
225                 230                 235                 240 
Ile Asn Glu Ile Ile Arg Val Leu Gln Leu Thr Ser Trp Asp Glu Asp 
                245                 250                 255     
Ala Trp Ala Ser Lys Asp Thr Glu Ala Met Lys Arg Ala Leu Ala Ser 
            260                 265                 270         
Ile Asp Ser Lys Leu Asn Gln Ala Lys Gly Trp Leu Arg Asp Pro Ser 
        275                 280                 285             
Ala Ser Pro Gly Asp Ala Gly Glu Gln Ala Ile Arg Gln Ile Leu Asp 
    290                 295                 300                 
Glu Ala Gly Lys Val Gly Glu Leu Cys Ala Gly Lys Glu Arg Arg Glu 
305                 310                 315                 320 
Ile Leu Gly Thr Cys Lys Met Leu Gly Gln Met Thr Asp Gln Val Ala 
                325                 330                 335     
Asp Leu Arg Ala Arg Gly Gln Gly Ser Ser Pro Val Ala Met Gln Lys 
            340                 345                 350         
Ala Gln Gln Val Ser Gln Gly Leu Asp Val Leu Thr Ala Lys Val Glu 
        355                 360                 365             
Asn Ala Ala Arg Lys Leu Glu Ala Met Thr Asn Ser Lys Gln Ser Ile 
    370                 375                 380                 
Ala Lys Lys Ile Asp Ala Ala Gln Asn Trp Leu Ala Asp Pro Asn Gly 
385                 390                 395                 400 
Gly Pro Glu Gly Glu Glu Gln Ile Arg Gly Ala Leu Ala Glu Ala Arg 
                405                 410                 415     
Lys Ile Ala Glu Leu Cys Asp Asp Pro Lys Glu Arg Asp Asp Ile Leu 
            420                 425                 430         
Arg Ser Leu Gly Glu Ile Ser Ala Leu Thr Ser Lys Leu Ala Asp Leu 
        435                 440                 445             
Arg Arg Gln Gly Lys Gly Asp Ser Pro Glu Ala Arg Ala Leu Ala Lys 
    450                 455                 460                 
Gln Val Ala Thr Ala Leu Gln Asn Leu Gln Thr Lys Thr Asn Arg Ala 
465                 470                 475                 480 
Val Ala Asn Ser Arg Pro Ala Lys Ala Ala Val His Leu Glu Gly Lys 
                485                 490                 495     
Ile Glu Gln Ala Gln Arg Trp Ile Asp Asn Pro Thr Val Asp Asp Arg 
            500                 505                 510         
Gly Val Gly Gln Ala Ala Ile Arg Gly Leu Val Ala Glu Gly His Arg 
        515                 520                 525             
Leu Ala Asn Val Met Met Gly Pro Tyr Arg Gln Asp Leu Leu Ala Lys 
    530                 535                 540                 
Cys Asp Arg Val Asp Gln Leu Thr Ala Gln Leu Ala Asp Leu Ala Ala 
545                 550                 555                 560 
Arg Gly Glu Gly Glu Ser Pro Gln Ala Arg Ala Leu Ala Ser Gln Leu 
                565                 570                 575     
Gln Asp Ser Leu Lys Asp Leu Lys Ala Arg Met Gln Glu Ala Met Thr 
            580                 585                 590         
Gln Glu Val Ser Asp Val Phe Ser Asp Thr Thr Thr Pro Ile Lys Leu 
        595                 600                 605             
Leu Ala Val Ala Ala Thr Ala Pro Pro Asp Ala Pro Asn Arg Glu Glu 
    610                 615                 620                 
Val Phe Asp Glu Arg Ala Ala Asn Phe Glu Asn His Ser Gly Lys Leu 
625                 630                 635                 640 
Gly Ala Thr Ala Glu Lys Ala Ala Ala Val Gly Thr Ala Asn Lys Ser 
                645                 650                 655     
Thr Val Glu Gly Ile Gln Ala Ser Val Lys Thr Ala Arg Glu Leu Thr 
            660                 665                 670         
Pro Gln Val Val Ser Ala Ala Arg Ile Leu Leu Arg Asn Pro Gly Asn 
        675                 680                 685             
Gln Ala Ala Tyr Glu His Phe Glu Thr Met Lys Asn Gln Trp Ile Asp 
    690                 695                 700                 
Asn Val Glu Lys Met Thr Gly Leu Val Asp Glu Ala Ile Asp Thr Lys 
705                 710                 715                 720 
Ser Leu Leu Asp Ala Ser Glu Glu Ala Ile Lys Lys Asp Leu Asp Lys 
                725                 730                 735     
Cys Lys Val Ala Met Ala Asn Ile Gln Pro Gln Met Leu Val Ala Gly 
            740                 745                 750         
Ala Thr Ser Ile Ala Arg Arg Ala Asn Arg Ile Leu Leu Val Ala Lys 
        755                 760                 765             
Arg Glu Val Glu Asn Ser Glu Asp Pro Lys Phe Arg Glu Ala Val Lys 
    770                 775                 780                 
Ala Ala Ser Asp Glu Leu Ser Lys Thr Ile Ser Pro Met Val Met Asp 
785                 790                 795                 800 
Ala Lys Ala Val Ala Gly Asn Ile Ser Asp Pro Gly Leu Gln Lys Ser 
                805                 810                 815     
Phe Leu Asp Ser Gly Tyr Arg Ile Leu Gly Ala Val Ala Lys Val Arg 
            820                 825                 830         
Glu Ala Phe Gln Pro Gln Glu Pro Asp Phe Pro Pro Pro Pro Pro Asp 
        835                 840                 845             
Leu Glu Gln Leu Arg Leu Thr Asp Glu Leu Ala Pro Pro Lys Pro Pro 
    850                 855                 860                 
Leu Pro Glu Gly Glu Val Pro Pro Pro Arg Pro Pro Pro Pro Glu Glu 
865                 870                 875                 880 
Lys Asp Glu Glu Phe Pro Glu Gln Lys Ala Gly Glu Val Ile Asn Gln 
                885                 890                 895     
Pro Met Met Met Ala Ala Arg Gln Leu His Asp Glu Ala Arg Lys Trp 
            900                 905                 910         
Ser Ser Lys Gly Asn Asp Ile Ile Ala Ala Ala Lys Arg Met Ala Leu 
        915                 920                 925             
Leu Met Ala Glu Met Ser Arg Leu Val Arg Gly Gly Ser Gly Thr Lys 
    930                 935                 940                 
Arg Ala Leu Ile Gln Cys Ala Lys Asp Ile Ala Lys Ala Ser Asp Glu 
945                 950                 955                 960 
Val Thr Arg Leu Ala Lys Glu Val Ala Lys Gln Cys Thr Asp Lys Arg 
                965                 970                 975     
Ile Arg Thr Asn Leu Leu Gln Val Cys Glu Arg Ile Pro Thr Ile Ser 
            980                 985                 990         
Thr Gln Leu Lys Ile Leu Ser Thr Val Lys Ala Thr Met Leu Gly Arg 
        995                 1000                1005            
Thr Asn Ile Ser Asp Glu Glu Ser Glu Gln Ala Thr Glu Met Leu Val 
    1010                1015                1020                
His Asn Ala Gln Asn Leu Met Gln Ser Val Lys Glu Thr Val Arg Glu 
1025                1030                1035                1040
Ala Glu Ala Ala Ser Ile Lys Ile Arg Thr Asp Ala Gly Phe Thr Leu 
                1045                1050                1055    
Arg Trp Val Arg Lys Thr Pro Trp Tyr Gln 
            1060                1065    

<210> 13
<211> 1134
<212> PRT
<213> Homo sapiens


<220> 
<223> Vinculin (VCL)

<400> 13
Met Pro Val Phe His Thr Arg Thr Ile Glu Ser Ile Leu Glu Pro Val 
1               5                   10                  15      
Ala Gln Gln Ile Ser His Leu Val Ile Met His Glu Glu Gly Glu Val 
            20                  25                  30          
Asp Gly Lys Ala Ile Pro Asp Leu Thr Ala Pro Val Ala Ala Val Gln 
        35                  40                  45              
Ala Ala Val Ser Asn Leu Val Arg Val Gly Lys Glu Thr Val Gln Thr 
    50                  55                  60                  
Thr Glu Asp Gln Ile Leu Lys Arg Asp Met Pro Pro Ala Phe Ile Lys 
65                  70                  75                  80  
Val Glu Asn Ala Cys Thr Lys Leu Val Gln Ala Ala Gln Met Leu Gln 
                85                  90                  95      
Ser Asp Pro Tyr Ser Val Pro Ala Arg Asp Tyr Leu Ile Asp Gly Ser 
            100                 105                 110         
Arg Gly Ile Leu Ser Gly Thr Ser Asp Leu Leu Leu Thr Phe Asp Glu 
        115                 120                 125             
Ala Glu Val Arg Lys Ile Ile Arg Val Cys Lys Gly Ile Leu Glu Tyr 
    130                 135                 140                 
Leu Thr Val Ala Glu Val Val Glu Thr Met Glu Asp Leu Val Thr Tyr 
145                 150                 155                 160 
Thr Lys Asn Leu Gly Pro Gly Met Thr Lys Met Ala Lys Met Ile Asp 
                165                 170                 175     
Glu Arg Gln Gln Glu Leu Thr His Gln Glu His Arg Val Met Leu Val 
            180                 185                 190         
Asn Ser Met Asn Thr Val Lys Glu Leu Leu Pro Val Leu Ile Ser Ala 
        195                 200                 205             
Met Lys Ile Phe Val Thr Thr Lys Asn Ser Lys Asn Gln Gly Ile Glu 
    210                 215                 220                 
Glu Ala Leu Lys Asn Arg Asn Phe Thr Val Glu Lys Met Ser Ala Glu 
225                 230                 235                 240 
Ile Asn Glu Ile Ile Arg Val Leu Gln Leu Thr Ser Trp Asp Glu Asp 
                245                 250                 255     
Ala Trp Ala Ser Lys Asp Thr Glu Ala Met Lys Arg Ala Leu Ala Ser 
            260                 265                 270         
Ile Asp Ser Lys Leu Asn Gln Ala Lys Gly Trp Leu Arg Asp Pro Ser 
        275                 280                 285             
Ala Ser Pro Gly Asp Ala Gly Glu Gln Ala Ile Arg Gln Ile Leu Asp 
    290                 295                 300                 
Glu Ala Gly Lys Val Gly Glu Leu Cys Ala Gly Lys Glu Arg Arg Glu 
305                 310                 315                 320 
Ile Leu Gly Thr Cys Lys Met Leu Gly Gln Met Thr Asp Gln Val Ala 
                325                 330                 335     
Asp Leu Arg Ala Arg Gly Gln Gly Ser Ser Pro Val Ala Met Gln Lys 
            340                 345                 350         
Ala Gln Gln Val Ser Gln Gly Leu Asp Val Leu Thr Ala Lys Val Glu 
        355                 360                 365             
Asn Ala Ala Arg Lys Leu Glu Ala Met Thr Asn Ser Lys Gln Ser Ile 
    370                 375                 380                 
Ala Lys Lys Ile Asp Ala Ala Gln Asn Trp Leu Ala Asp Pro Asn Gly 
385                 390                 395                 400 
Gly Pro Glu Gly Glu Glu Gln Ile Arg Gly Ala Leu Ala Glu Ala Arg 
                405                 410                 415     
Lys Ile Ala Glu Leu Cys Asp Asp Pro Lys Glu Arg Asp Asp Ile Leu 
            420                 425                 430         
Arg Ser Leu Gly Glu Ile Ser Ala Leu Thr Ser Lys Leu Ala Asp Leu 
        435                 440                 445             
Arg Arg Gln Gly Lys Gly Asp Ser Pro Glu Ala Arg Ala Leu Ala Lys 
    450                 455                 460                 
Gln Val Ala Thr Ala Leu Gln Asn Leu Gln Thr Lys Thr Asn Arg Ala 
465                 470                 475                 480 
Val Ala Asn Ser Arg Pro Ala Lys Ala Ala Val His Leu Glu Gly Lys 
                485                 490                 495     
Ile Glu Gln Ala Gln Arg Trp Ile Asp Asn Pro Thr Val Asp Asp Arg 
            500                 505                 510         
Gly Val Gly Gln Ala Ala Ile Arg Gly Leu Val Ala Glu Gly His Arg 
        515                 520                 525             
Leu Ala Asn Val Met Met Gly Pro Tyr Arg Gln Asp Leu Leu Ala Lys 
    530                 535                 540                 
Cys Asp Arg Val Asp Gln Leu Thr Ala Gln Leu Ala Asp Leu Ala Ala 
545                 550                 555                 560 
Arg Gly Glu Gly Glu Ser Pro Gln Ala Arg Ala Leu Ala Ser Gln Leu 
                565                 570                 575     
Gln Asp Ser Leu Lys Asp Leu Lys Ala Arg Met Gln Glu Ala Met Thr 
            580                 585                 590         
Gln Glu Val Ser Asp Val Phe Ser Asp Thr Thr Thr Pro Ile Lys Leu 
        595                 600                 605             
Leu Ala Val Ala Ala Thr Ala Pro Pro Asp Ala Pro Asn Arg Glu Glu 
    610                 615                 620                 
Val Phe Asp Glu Arg Ala Ala Asn Phe Glu Asn His Ser Gly Lys Leu 
625                 630                 635                 640 
Gly Ala Thr Ala Glu Lys Ala Ala Ala Val Gly Thr Ala Asn Lys Ser 
                645                 650                 655     
Thr Val Glu Gly Ile Gln Ala Ser Val Lys Thr Ala Arg Glu Leu Thr 
            660                 665                 670         
Pro Gln Val Val Ser Ala Ala Arg Ile Leu Leu Arg Asn Pro Gly Asn 
        675                 680                 685             
Gln Ala Ala Tyr Glu His Phe Glu Thr Met Lys Asn Gln Trp Ile Asp 
    690                 695                 700                 
Asn Val Glu Lys Met Thr Gly Leu Val Asp Glu Ala Ile Asp Thr Lys 
705                 710                 715                 720 
Ser Leu Leu Asp Ala Ser Glu Glu Ala Ile Lys Lys Asp Leu Asp Lys 
                725                 730                 735     
Cys Lys Val Ala Met Ala Asn Ile Gln Pro Gln Met Leu Val Ala Gly 
            740                 745                 750         
Ala Thr Ser Ile Ala Arg Arg Ala Asn Arg Ile Leu Leu Val Ala Lys 
        755                 760                 765             
Arg Glu Val Glu Asn Ser Glu Asp Pro Lys Phe Arg Glu Ala Val Lys 
    770                 775                 780                 
Ala Ala Ser Asp Glu Leu Ser Lys Thr Ile Ser Pro Met Val Met Asp 
785                 790                 795                 800 
Ala Lys Ala Val Ala Gly Asn Ile Ser Asp Pro Gly Leu Gln Lys Ser 
                805                 810                 815     
Phe Leu Asp Ser Gly Tyr Arg Ile Leu Gly Ala Val Ala Lys Val Arg 
            820                 825                 830         
Glu Ala Phe Gln Pro Gln Glu Pro Asp Phe Pro Pro Pro Pro Pro Asp 
        835                 840                 845             
Leu Glu Gln Leu Arg Leu Thr Asp Glu Leu Ala Pro Pro Lys Pro Pro 
    850                 855                 860                 
Leu Pro Glu Gly Glu Val Pro Pro Pro Arg Pro Pro Pro Pro Glu Glu 
865                 870                 875                 880 
Lys Asp Glu Glu Phe Pro Glu Gln Lys Ala Gly Glu Val Ile Asn Gln 
                885                 890                 895     
Pro Met Met Met Ala Ala Arg Gln Leu His Asp Glu Ala Arg Lys Trp 
            900                 905                 910         
Ser Ser Lys Pro Gly Ile Pro Ala Ala Glu Val Gly Ile Gly Val Val 
        915                 920                 925             
Ala Glu Ala Asp Ala Ala Asp Ala Ala Gly Phe Pro Val Pro Pro Asp 
    930                 935                 940                 
Met Glu Asp Asp Tyr Glu Pro Glu Leu Leu Leu Met Pro Ser Asn Gln 
945                 950                 955                 960 
Pro Val Asn Gln Pro Ile Leu Ala Ala Ala Gln Ser Leu His Arg Glu 
                965                 970                 975     
Ala Thr Lys Trp Ser Ser Lys Gly Asn Asp Ile Ile Ala Ala Ala Lys 
            980                 985                 990         
Arg Met Ala Leu Leu Met Ala Glu Met Ser Arg Leu Val Arg Gly Gly 
        995                 1000                1005            
Ser Gly Thr Lys Arg Ala Leu Ile Gln Cys Ala Lys Asp Ile Ala Lys 
    1010                1015                1020                
Ala Ser Asp Glu Val Thr Arg Leu Ala Lys Glu Val Ala Lys Gln Cys 
1025                1030                1035                1040
Thr Asp Lys Arg Ile Arg Thr Asn Leu Leu Gln Val Cys Glu Arg Ile 
                1045                1050                1055    
Pro Thr Ile Ser Thr Gln Leu Lys Ile Leu Ser Thr Val Lys Ala Thr 
            1060                1065                1070        
Met Leu Gly Arg Thr Asn Ile Ser Asp Glu Glu Ser Glu Gln Ala Thr 
        1075                1080                1085            
Glu Met Leu Val His Asn Ala Gln Asn Leu Met Gln Ser Val Lys Glu 
    1090                1095                1100                
Thr Val Arg Glu Ala Glu Ala Ala Ser Ile Lys Ile Arg Thr Asp Ala 
1105                1110                1115                1120
Gly Phe Thr Leu Arg Trp Val Arg Lys Thr Pro Trp Tyr Gln 
                1125                1130                

<210> 14
<211> 222
<212> PRT
<213> Homo sapiens


<220> 
<223> Vinculin (VCL)

<400> 14
Met Pro Pro Ala Phe Ile Lys Val Glu Asn Ala Cys Thr Lys Leu Val 
1               5                   10                  15      
Gln Ala Ala Gln Met Leu Gln Ser Asp Pro Tyr Ser Val Pro Ala Arg 
            20                  25                  30          
Asp Tyr Leu Ile Asp Gly Ser Arg Gly Ile Leu Ser Gly Thr Ser Asp 
        35                  40                  45              
Leu Leu Leu Thr Phe Asp Glu Ala Glu Val Arg Lys Ile Ile Arg Val 
    50                  55                  60                  
Cys Lys Gly Ile Leu Glu Tyr Leu Thr Val Ala Glu Val Val Glu Thr 
65                  70                  75                  80  
Met Glu Asp Leu Val Thr Tyr Thr Lys Asn Leu Gly Pro Gly Met Thr 
                85                  90                  95      
Lys Met Ala Lys Met Ile Asp Glu Arg Gln Gln Glu Leu Thr His Gln 
            100                 105                 110         
Glu His Arg Val Met Leu Val Asn Ser Met Asn Thr Val Lys Glu Leu 
        115                 120                 125             
Leu Pro Val Leu Ile Ser Ala Met Lys Ile Phe Val Thr Thr Lys Asn 
    130                 135                 140                 
Ser Lys Asn Gln Gly Ile Glu Glu Ala Leu Lys Asn Arg Asn Phe Thr 
145                 150                 155                 160 
Val Glu Lys Met Ser Ala Glu Ile Asn Glu Ile Ile Arg Val Leu Gln 
                165                 170                 175     
Leu Thr Ser Trp Asp Glu Asp Ala Trp Ala Ser Lys Val Arg Val Leu 
            180                 185                 190         
Ser Gly Glu Ile Ser Lys Ile Pro Asn Ser Pro Trp Leu Gly Val Leu 
        195                 200                 205             
Ile Gly Thr Cys Leu Ile Leu Tyr Leu Val Ile Phe Val Ala 
    210                 215                 220         

<210> 15
<211> 212
<212> PRT
<213> Homo sapiens


<220> 
<223> Pre-pro Endothelin 1 (ET-1)

<400> 15
Met Asp Tyr Leu Leu Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      
Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly 
            20                  25                  30          
Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              
Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  
Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  
Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      
Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         
Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             
Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 
Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 
Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     
Thr Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         
Pro Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn 
        195                 200                 205             
Arg Ala His Trp 
    210         

<210> 16
<211> 195
<212> PRT
<213> Homo sapiens


<220> 
<223> Pre-pro Endothelin 1 (ET-1)

<400> 16
Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly Glu 
1               5                   10                  15      
Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg Arg 
            20                  25                  30          
Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr 
        35                  40                  45              
Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val Val 
    50                  55                  60                  
Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn Leu 
65                  70                  75                  80  
Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala Ser 
                85                  90                  95      
Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu Leu 
            100                 105                 110         
Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys Gly 
        115                 120                 125             
Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu Val 
    130                 135                 140                 
Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln Thr 
145                 150                 155                 160 
Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp Pro 
                165                 170                 175     
Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn Arg 
            180                 185                 190         
Ala His Trp 
        195 

<210> 17
<211> 21
<212> PRT
<213> Homo sapiens


<220> 
<223> Pre-pro Endothelin 1 (ET-1)

<400> 17
Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr Phe Cys His 
1               5                   10                  15      
Leu Asp Ile Ile Trp 
            20      

<210> 18
<211> 45
<212> PRT
<213> Homo sapiens


<220> 
<223> Pre-pro Endothelin 1 (ET-1)

<400> 18
Arg Ser Ser Glu Glu His Leu Arg Gln Thr Arg Ser Glu Thr Met Arg 
1               5                   10                  15      
Asn Ser Val Lys Ser Ser Phe His Asp Pro Lys Leu Lys Gly Lys Pro 
            20                  25                  30          
Ser Arg Glu Arg Tyr Val Thr His Asn Arg Ala His Trp 
        35                  40                  45  

<210> 19
<211> 38
<212> PRT
<213> Homo sapiens


<220> 
<223> Pre-pro Endothelin 1 (ET-1)

<400> 19
Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr Phe Cys His 
1               5                   10                  15      
Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val Val Pro Tyr Gly 
            20                  25                  30          
Leu Gly Ser Pro Arg Ser 
        35              

<210> 20
<211> 116
<212> PRT
<213> Homo sapiens


<220> 
<223> Procalcitonin (PCT)

<400> 20
Ala Pro Phe Arg Ser Ala Leu Glu Ser Ser Pro Ala Asp Pro Ala Thr 
1               5                   10                  15      
Leu Ser Glu Asp Glu Ala Arg Leu Leu Leu Ala Ala Leu Val Gln Asp 
            20                  25                  30          
Tyr Val Gln Met Lys Ala Ser Glu Leu Glu Gln Glu Gln Glu Arg Glu 
        35                  40                  45              
Gly Ser Ser Leu Asp Ser Pro Arg Ser Lys Arg Cys Gly Asn Leu Ser 
    50                  55                  60                  
Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe Asn Lys Phe His Thr 
65                  70                  75                  80  
Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro Gly Lys Lys Arg Asp 
                85                  90                  95      
Met Ser Ser Asp Leu Glu Arg Asp His Arg Pro His Val Ser Met Pro 
            100                 105                 110         
Gln Asn Ala Asn 
        115     

<210> 21
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of ICAM1

<400> 21
Leu Leu Gly Ile Glu Thr Pro Leu Pro Lys 
1               5                   10  

<210> 22
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of AHSG

<400> 22
Phe Ser Val Val Tyr Ala Lys 
1               5           

<210> 23
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of CPN1

<400> 23
Val Gln Asn Glu Cys Pro Gly Ile Thr Arg 
1               5                   10  

<210> 24
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of FABP1

<400> 24
Ala Ile Gly Leu Pro Glu Glu Leu Ile Gln Lys 
1               5                   10      

<210> 25
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of HRG

<400> 25
Asp Gly Tyr Leu Phe Gln Leu Leu Arg 
1               5                   

<210> 26
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of PIGR

<400> 26
Cys Gly Leu Gly Ile Asn Ser Arg 
1               5               

<210> 27
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of RAP1A/RAP1B/RAPBL

<400> 27
Glu Gln Gly Gln Asn Leu Ala Arg 
1               5               

<210> 28
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of THBS1

<400> 28
Phe Val Phe Gly Thr Thr Pro Glu Asp Ile Leu Arg 
1               5                   10          

<210> 29
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> SRM peptide of VCL

<400> 29
Gly Asn Asp Ile Ile Ala Ala Ala Lys 
1               5                   

