                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Prodrugs comprising an GLP-1/Glucagon/GIP triple agonist linker hyaluronic acid conjugate

<130>  DE2018-034 WOPCT


<160>  7   

<170>  PatentIn version 3.5




<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Arg is modified with an NH2 group

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  liraglutide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys derivatized at N6 with 
       (S)-4-carboxy-4-hexadecanoylamino-butyryl

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Thr is modified with an OH group

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Val Gln Trp Leu Met Asn Thr 
            20                  25              

<210>  4
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is modified with an NH2 group

<400>  4

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  42
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  Gln is modified with an OH group

<400>  5

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


         
<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4-analogue

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is a 2-Methylalanine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 
       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylamino)-butyryl)

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Xaa is a 2-Methylalanine

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Lys is modified with an NH2 group

<400>  6

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Lys Glu Glu 
1               5                   10                  15      


Gln Arg Gln Lys Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly His Pro 
            20                  25                  30          


Ser Xaa Lys Pro Pro Pro Lys 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4-analogue

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is a 2-Methylalanine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 
       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylamino)-butyryl)

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is a 2-Methylalanine

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is a D-alanine

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Xaa is a 2-Methylalanine

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Lys is modified with an NH2 group

<400>  7

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Lys Glu Glu 
1               5                   10                  15      


Gln Arg Gln Xaa Glu Phe Ile Glu Trp Leu Lys Ala Xaa Gly Pro Pro 
            20                  25                  30          


Ser Xaa Lys Pro Pro Pro Lys 
        35                  






