﻿               SEQUENCE LISTING

<110> NEOVACS
      INSERM (Institut National de la Santé et de la Recherche
      Médicale)
      INSTITUT PASTEUR
      Grouard-Vogel Géraldine
      Conde García Eva
      Bertrand Romain
      Caillot Noémie
      Reber Laurent
      Bruhns Pierre
      Serra Vincent

<120> IMMUNOGENIC PRODUCT COMPRISING IL-4 AND/OR IL-13 FOR 
      TREATING DISORDERS ASSOCIATED WITH ABERRANT IL-4 AND/OR 
      IL-13 EXPRESSION OR ACTIVITY

<130> CV-1058/PCT/2

<160> 8

<170> BiSSAP 1.3.6

<210> 1
<211> 535
<212> PRT
<213> Artificial Sequence


<220> 
<223> CRM197

<400> 1
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      
Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          
Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              
Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  
Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  
Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      
Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         
Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             
Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 
Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 
Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     
Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         
Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             
Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 
Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 
Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     
His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         
Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             
Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 
Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 
Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     
Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         
Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             
Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 
Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 
Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     
Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         
Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             
His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 
Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 
Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     
Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         
Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             
Leu Phe Phe Glu Ile Lys Ser 
    530                 535 

<210> 2
<211> 129
<212> PRT
<213> Homo sapiens


<220> 
<223> Human IL-4

<400> 2
His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      
Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          
Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              
Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  
Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  
Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      
Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         
Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             
Ser 
    

<210> 3
<211> 22
<212> PRT
<213> Homo sapiens


<220> 
<223> Fragment of Human IL-4

<400> 3
Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg 
1               5                   10                  15      
Leu Asp Arg Asn Leu Trp 
            20          

<210> 4
<211> 120
<212> PRT
<213> Mus musculus


<220> 
<223> Murine IL-4

<400> 4
His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu Ile Ile Gly Ile 
1               5                   10                  15      
Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr Glu Met Asp Val 
            20                  25                  30          
Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu Ser Glu Leu Val 
        35                  40                  45              
Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu Lys His Gly Lys 
    50                  55                  60                  
Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met Glu Leu Gln Arg 
65                  70                  75                  80  
Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile Ser Cys Thr Met 
                85                  90                  95      
Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu Glu Ser Leu Lys 
            100                 105                 110         
Ser Ile Met Gln Met Asp Tyr Ser 
        115                 120 

<210> 5
<211> 108
<212> PRT
<213> Canis


<220> 
<223> Canine IL-4

<400> 5
His Asn Phe Asn Ile Thr Ile Lys Glu Ile Ile Lys Met Leu Asn Ile 
1               5                   10                  15      
Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Lys Asp Val 
            20                  25                  30          
Phe Thr Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              
Ala Thr Val Leu Arg Gln Ile Tyr Thr His Asn Cys Ser Asn Arg Tyr 
    50                  55                  60                  
Leu Arg Gly Leu Tyr Arg Asn Leu Ser Ser Met Ala Asn Lys Thr Cys 
65                  70                  75                  80  
Ser Met Asn Glu Ile Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg 
                85                  90                  95      
Leu Lys Val Ile Met Gln Lys Lys Tyr Tyr Arg His 
            100                 105             

<210> 6
<211> 122
<212> PRT
<213> Homo sapiens


<220> 
<223> Human IL-13

<400> 6
Leu Thr Cys Leu Gly Gly Phe Ala Ser Pro Gly Pro Val Pro Pro Ser 
1               5                   10                  15      
Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn 
            20                  25                  30          
Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu 
        35                  40                  45              
Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser 
    50                  55                  60                  
Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys 
65                  70                  75                  80  
Pro His Lys Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp 
                85                  90                  95      
Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu 
            100                 105                 110         
Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn 
        115                 120         

<210> 7
<211> 110
<212> PRT
<213> Mus musculus


<220> 
<223> Murine IL-13

<400> 7
Pro Val Pro Arg Ser Val Ser Leu Pro Leu Thr Leu Lys Glu Leu Ile 
1               5                   10                  15      
Glu Glu Leu Ser Asn Ile Thr Gln Asp Gln Thr Pro Leu Cys Asn Gly 
            20                  25                  30          
Ser Met Val Trp Ser Val Asp Leu Ala Ala Gly Gly Phe Cys Val Ala 
        35                  40                  45              
Leu Asp Ser Leu Thr Asn Ile Ser Asn Cys Asn Ala Ile Tyr Arg Thr 
    50                  55                  60                  
Gln Arg Ile Leu His Gly Leu Cys Asn Arg Lys Ala Pro Thr Thr Val 
65                  70                  75                  80  
Ser Ser Leu Pro Asp Thr Lys Ile Glu Val Ala His Phe Ile Thr Lys 
                85                  90                  95      
Leu Leu Ser Tyr Thr Lys Gln Leu Phe Arg His Gly Pro Phe 
            100                 105                 110 

<210> 8
<211> 113
<212> PRT
<213> Canis


<220> 
<223> Canine IL-13

<400> 8
Ser Pro Ser Pro Val Thr Pro Ser Pro Thr Leu Lys Glu Leu Ile Glu 
1               5                   10                  15      
Glu Leu Val Asn Ile Thr Gln Asn Gln Ala Ser Leu Cys Asn Gly Ser 
            20                  25                  30          
Met Val Trp Ser Val Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              
Glu Ser Leu Ile Asn Val Ser Asp Cys Ser Ala Ile Gln Arg Thr Gln 
    50                  55                  60                  
Arg Met Leu Lys Ala Leu Cys Ser Gln Lys Pro Ala Ala Gly Gln Ile 
65                  70                  75                  80  
Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln Leu Val 
                85                  90                  95      
Lys Asn Leu Leu Thr Tyr Val Arg Gly Val Tyr Arg His Gly Asn Phe 
            100                 105                 110         
Arg 
    

