                         SEQUENCE LISTING

<110>  ESTEVE PHARMACEUTICALS, S.A.
       Universitat Autnoma de Barcelona
 
<120>  ADENOASSOCIATED VIRUS VECTORS FOR THE TREATMENT OF 
       MUCOPOLYSACCHARIDOSES TYPE IV A

<130>  EP2212.10

<150>  EP18382373.1
<151>  2018-05-30

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  1577
<212>  DNA
<213>  Homo sapiens

<400>  1
tgccaccatg gcggcggttg tcgcggcgac gaggtggtgg cagctgttgc tggtgctcag       60

cgccgcgggg atgggggcct cgggcgcccc gcagcccccc aacatcctgc tcctgctcat      120

ggacgacatg ggatggggtg acctcggggt gtatggagag ccctccagag agaccccgaa      180

tttggaccgg atggctgcag aagggctgct tttcccaaac ttctattctg ccaaccctct      240

gtgctcgcca tcgagggcgg cactgctcac aggacggcta cccatccgca atggcttcta      300

caccaccaac gcccatgcca gaaacgccta cacaccgcag gagattgtgg gcggcatccc      360

agactcggag cagctcctgc cggagcttct gaagaaggcc ggctacgtca gcaagattgt      420

cggcaagtgg catctgggtc acaggcccca gttccacccc ctgaagcacg gatttgatga      480

gtggtttgga tcccccaact gccactttgg accttatgac aacaaggcca ggcccaacat      540

ccctgtgtac agggactggg agatggttgg cagatattat gaagaatttc ctattaatct      600

gaagacgggg gaagccaacc tcacccagat ctacctgcag gaagccctgg acttcattaa      660

gagacaggca cggcaccacc cctttttcct ctactgggct gtcgacgcca cgcacgcacc      720

cgtctatgcc tccaaaccct tcttgggcac cagtcagcga gggcggtatg gagacgccgt      780

ccgggagatt gatgacagca ttgggaagat actggagctc ctccaagacc tgcacgtcgc      840

ggacaacacc ttcgtcttct tcacgtcgga caacggcgct gccctcattt ccgcccccga      900

acaaggtggc agcaacggcc cctttctgtg tgggaagcag accacgtttg aaggagggat      960

gagggagcct gccctcgcat ggtggccagg gcacgtcact gcaggccagg tgagccacca     1020

gctgggcagc atcatggacc tcttcaccac cagcctggcc cttgcgggcc tgacgccgcc     1080

cagcgacagg gccattgatg gcctcaacct cctccccacc ctcctgcagg gccggctgat     1140

ggacaggcct atcttctatt accgtggcga cacgctgatg gcggccaccc tcgggcagca     1200

caaggctcac ttctggacct ggaccaactc ctgggagaac ttcagacagg gcattgattt     1260

ctgccctggg cagaacgttt caggggtcac aactcacaat ctggaagacc acacgaagct     1320

gcccctgatc ttccacctgg gacgggaccc aggggagagg ttccccctca gctttgccag     1380

cgccgagtac caggaggccc tcagcaggat cacctcggtc gtccagcagc accaggaggc     1440

cttggtcccc gcgcagcccc agctcaacgt gtgcaactgg gcggtcatga actgggcacc     1500

tccgggctgt gaaaagttag ggaagtgtct gacacctcca gaatccattc ccaagaagtg     1560

cctctggtcc cactagg                                                    1577


<210>  2
<211>  7804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-hGALNS

<400>  2
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggcg gcggttgtcg cggcgacgag gtggtggcag ctgttgctgg tgctcagcgc     1980

cgcggggatg ggggcctcgg gcgccccgca gccccccaac atcctgctcc tgctcatgga     2040

cgacatggga tggggtgacc tcggggtgta tggagagccc tccagagaga ccccgaattt     2100

ggaccggatg gctgcagaag ggctgctttt cccaaacttc tattctgcca accctctgtg     2160

ctcgccatcg agggcggcac tgctcacagg acggctaccc atccgcaatg gcttctacac     2220

caccaacgcc catgccagaa acgcctacac accgcaggag attgtgggcg gcatcccaga     2280

ctcggagcag ctcctgccgg agcttctgaa gaaggccggc tacgtcagca agattgtcgg     2340

caagtggcat ctgggtcaca ggccccagtt ccaccccctg aagcacggat ttgatgagtg     2400

gtttggatcc cccaactgcc actttggacc ttatgacaac aaggccaggc ccaacatccc     2460

tgtgtacagg gactgggaga tggttggcag atattatgaa gaatttccta ttaatctgaa     2520

gacgggggaa gccaacctca cccagatcta cctgcaggaa gccctggact tcattaagag     2580

acaggcacgg caccacccct ttttcctcta ctgggctgtc gacgccacgc acgcacccgt     2640

ctatgcctcc aaacccttct tgggcaccag tcagcgaggg cggtatggag acgccgtccg     2700

ggagattgat gacagcattg ggaagatact ggagctcctc caagacctgc acgtcgcgga     2760

caacaccttc gtcttcttca cgtcggacaa cggcgctgcc ctcatttccg cccccgaaca     2820

aggtggcagc aacggcccct ttctgtgtgg gaagcagacc acgtttgaag gagggatgag     2880

ggagcctgcc ctcgcatggt ggccagggca cgtcactgca ggccaggtga gccaccagct     2940

gggcagcatc atggacctct tcaccaccag cctggccctt gcgggcctga cgccgcccag     3000

cgacagggcc attgatggcc tcaacctcct ccccaccctc ctgcagggcc ggctgatgga     3060

caggcctatc ttctattacc gtggcgacac gctgatggcg gccaccctcg ggcagcacaa     3120

ggctcacttc tggacctgga ccaactcctg ggagaacttc agacagggca ttgatttctg     3180

ccctgggcag aacgtttcag gggtcacaac tcacaatctg gaagaccaca cgaagctgcc     3240

cctgatcttc cacctgggac gggacccagg ggagaggttc cccctcagct ttgccagcgc     3300

cgagtaccag gaggccctca gcaggatcac ctcggtcgtc cagcagcacc aggaggcctt     3360

ggtccccgcg cagccccagc tcaacgtgtg caactgggcg gtcatgaact gggcacctcc     3420

gggctgtgaa aagttaggga agtgtctgac acctccagaa tccattccca agaagtgcct     3480

ctggtcccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4260

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4320

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4380

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4440

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4500

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4560

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4620

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     4680

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     4740

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     4800

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     4860

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     4920

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     4980

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5040

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5100

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5160

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5220

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5280

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5340

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5400

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5460

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5520

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5580

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     5640

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     5700

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     5760

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     5820

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     5880

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     5940

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6000

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6060

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6120

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6180

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     6240

aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc     6300

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca     6360

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg     6420

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat     6480

gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg     6540

caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc     6600

aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata     6660

aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga     6720

ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt     6780

tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct     6840

atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa     6900

actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag     6960

attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat     7020

ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa     7080

tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta     7140

ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca     7200

ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat     7260

cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg     7320

agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc     7380

acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat     7440

ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa     7500

caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt     7560

tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt     7620

cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc     7680

ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt     7740

cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac     7800

gcca                                                                  7804


<210>  3
<211>  1577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS ohGALNS-version1

<400>  3
tgccaccatg gctgctgtgg tggctgccac aagatggtgg cagctgctgc tggtgctgag       60

cgccgctgga atgggagctt ctggcgctcc ccagcccccc aatattctcc tgctgctgat      120

ggacgacatg ggctggggcg atctgggagt gtacggcgag cctagcagag agacacccaa      180

cctggacaga atggccgccg agggcctgct gttccccaac ttctacagcg ccaaccccct      240

gtgcagccca tctagagccg ctctgctgac cggcagactg cccatcagaa acggcttcta      300

caccaccaac gcccacgccc ggaacgccta cacaccccag gaaatcgtgg gcggcatccc      360

cgatagcgaa cagctgctgc ctgagctgct gaagaaagcc ggctacgtgt ccaagatcgt      420

gggcaagtgg cacctgggcc acagacccca gttccaccct ctgaagcacg gcttcgacga      480

gtggttcggc agccccaatt gccacttcgg cccctacgac aacaaggcca gacccaacat      540

ccccgtgtac cgggactggg agatggtggg acggtactac gaagagttcc ccatcaacct      600

gaaaaccggc gaggccaacc tgacccagat ctacctgcag gaagccctgg acttcatcaa      660

gcggcaggcc cggcaccacc ctttctttct gtactgggcc gtggacgcca cccacgcccc      720

tgtgtatgcc agcaagcctt tcctgggcac cagccagaga ggcagatacg gcgacgccgt      780

gcgcgagatc gatgacagca tcggcaagat cctggaactg ctgcaggacc tgcacgtggc      840

cgacaacacc ttcgtgttct tcaccagcga caacggcgct gccctgatct ctgctcctga      900

gcagggcggc agcaacggcc catttctgtg tggcaagcag accaccttcg agggcggcat      960

gagagaacct gccctggctt ggtggcctgg ccatgtgaca gctggacagg tgtcccacca     1020

gctgggcagc atcatggacc tgttcaccac cagcctggcc ctggccggac tgacacctcc     1080

aagcgacaga gccatcgacg gcctgaacct gctgcctacc ctgctgcagg gacggctgat     1140

ggaccggccc atcttctact acagaggcga caccctgatg gccgccacac tgggacagca     1200

caaggcccac ttttggacct ggaccaacag ctgggagaac ttccggcagg gcatcgactt     1260

ttgccctggc cagaatgtgt ccggcgtgac cacccacaac ctggaagatc acaccaagct     1320

gcccctgatt ttccacctgg gcagagatcc cggcgagcgg ttccctctgt cttttgccag     1380

cgccgagtac caggaagctc tgagcagaat cacctccgtg gtgcagcagc accaggaagc     1440

actggtgcct gctcagcccc agctgaacgt gtgcaattgg gccgtgatga actgggcccc     1500

tcccggctgt gaaaagctgg gaaagtgcct gaccccccct gagagcatcc ccaagaaatg     1560

cctgtggtcc cactgag                                                    1577


<210>  4
<211>  7804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohGALNSversion1

<400>  4
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggct gctgtggtgg ctgccacaag atggtggcag ctgctgctgg tgctgagcgc     1980

cgctggaatg ggagcttctg gcgctcccca gccccccaat attctcctgc tgctgatgga     2040

cgacatgggc tggggcgatc tgggagtgta cggcgagcct agcagagaga cacccaacct     2100

ggacagaatg gccgccgagg gcctgctgtt ccccaacttc tacagcgcca accccctgtg     2160

cagcccatct agagccgctc tgctgaccgg cagactgccc atcagaaacg gcttctacac     2220

caccaacgcc cacgcccgga acgcctacac accccaggaa atcgtgggcg gcatccccga     2280

tagcgaacag ctgctgcctg agctgctgaa gaaagccggc tacgtgtcca agatcgtggg     2340

caagtggcac ctgggccaca gaccccagtt ccaccctctg aagcacggct tcgacgagtg     2400

gttcggcagc cccaattgcc acttcggccc ctacgacaac aaggccagac ccaacatccc     2460

cgtgtaccgg gactgggaga tggtgggacg gtactacgaa gagttcccca tcaacctgaa     2520

aaccggcgag gccaacctga cccagatcta cctgcaggaa gccctggact tcatcaagcg     2580

gcaggcccgg caccaccctt tctttctgta ctgggccgtg gacgccaccc acgcccctgt     2640

gtatgccagc aagcctttcc tgggcaccag ccagagaggc agatacggcg acgccgtgcg     2700

cgagatcgat gacagcatcg gcaagatcct ggaactgctg caggacctgc acgtggccga     2760

caacaccttc gtgttcttca ccagcgacaa cggcgctgcc ctgatctctg ctcctgagca     2820

gggcggcagc aacggcccat ttctgtgtgg caagcagacc accttcgagg gcggcatgag     2880

agaacctgcc ctggcttggt ggcctggcca tgtgacagct ggacaggtgt cccaccagct     2940

gggcagcatc atggacctgt tcaccaccag cctggccctg gccggactga cacctccaag     3000

cgacagagcc atcgacggcc tgaacctgct gcctaccctg ctgcagggac ggctgatgga     3060

ccggcccatc ttctactaca gaggcgacac cctgatggcc gccacactgg gacagcacaa     3120

ggcccacttt tggacctgga ccaacagctg ggagaacttc cggcagggca tcgacttttg     3180

ccctggccag aatgtgtccg gcgtgaccac ccacaacctg gaagatcaca ccaagctgcc     3240

cctgattttc cacctgggca gagatcccgg cgagcggttc cctctgtctt ttgccagcgc     3300

cgagtaccag gaagctctga gcagaatcac ctccgtggtg cagcagcacc aggaagcact     3360

ggtgcctgct cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc     3420

cggctgtgaa aagctgggaa agtgcctgac cccccctgag agcatcccca agaaatgcct     3480

gtggtcccac tgagaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4260

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4320

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4380

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4440

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4500

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4560

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4620

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     4680

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     4740

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     4800

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     4860

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     4920

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     4980

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5040

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5100

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5160

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5220

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5280

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5340

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5400

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5460

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5520

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5580

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     5640

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     5700

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     5760

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     5820

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     5880

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     5940

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6000

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6060

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6120

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6180

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     6240

aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc     6300

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca     6360

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg     6420

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat     6480

gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg     6540

caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc     6600

aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata     6660

aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga     6720

ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt     6780

tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct     6840

atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa     6900

actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag     6960

attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat     7020

ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa     7080

tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta     7140

ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca     7200

ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat     7260

cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg     7320

agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc     7380

acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat     7440

ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa     7500

caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt     7560

tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt     7620

cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc     7680

ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt     7740

cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac     7800

gcca                                                                  7804


<210>  5
<211>  1577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS ohGALNS-version2

<400>  5
tgccaccatg gccgccgtgg tcgccgcaac tcgatggtgg cagctgctgc tggtcctgtc       60

cgccgctggc atgggagcct ctggagcccc tcagccccct aacatcctgc tgctgctgat      120

ggacgatatg ggatggggcg acctgggcgt gtacggagag ccaagccggg agacacccaa      180

tctggatagg atggcagcag agggcctgct gttcccaaac ttttattccg ccaatcctct      240

gtgcagccca tcccgcgccg ccctgctgac cggccggctg cccatcagaa acggcttcta      300

caccacaaac gcccacgccc ggaatgccta tacacctcag gagatcgtgg gcggcatccc      360

cgactctgag cagctgctgc ctgagctgct gaagaaggcc ggctacgtga gcaagatcgt      420

gggcaagtgg cacctgggac acaggccaca gttccaccct ctgaagcacg gcttcgatga      480

gtggtttggc agccccaatt gtcactttgg cccttacgac aacaaggcca gacccaatat      540

ccccgtgtac agagattggg agatggtggg caggtactat gaggagttcc ctatcaacct      600

gaagaccggc gaggccaatc tgacacagat ctacctgcag gaggccctgg actttatcaa      660

gaggcaggcc cgccaccacc ccttctttct gtactgggca gtggatgcaa cccacgcacc      720

agtgtatgcc tctaagccct tcctgggcac aagccagagg ggcagatatg gcgacgccgt      780

gagagagatc gacgattcta tcggcaagat cctggagctg ctgcaggacc tgcacgtggc      840

cgataacacc ttcgtgttct tcacatccga taatggagcc gccctgatct ccgccccaga      900

gcagggagga tctaacggac ccttcctgtg cggcaagcag accacatttg agggaggaat      960

gagggagcct gccctggcat ggtggccagg ccacgtgacc gccggccagg tgagccacca     1020

gctgggctcc atcatggacc tgttcaccac aagcctggcc ctggcaggcc tgaccccacc     1080

atccgacaga gccatcgatg gcctgaatct gctgcctaca ctgctgcagg gcaggctgat     1140

ggaccgccca atcttctact ataggggcga taccctgatg gcagccacac tgggacagca     1200

caaggcacac ttttggacct ggacaaactc ctgggagaat ttccgccagg gcatcgattt     1260

ttgtccaggc cagaacgtgt ctggcgtgac cacacacaat ctggaggacc acaccaagct     1320

gcccctgatc tttcacctgg gccgggatcc tggcgagaga ttcccactgt cttttgccag     1380

cgccgagtac caggaggccc tgtcccggat cacatctgtg gtgcagcagc accaggaggc     1440

cctggtgcca gcacagcccc agctgaacgt gtgcaattgg gccgtgatga actgggcccc     1500

tccaggctgt gagaaactgg gcaaatgtct gactccccct gaatctatcc ctaagaagtg     1560

tctgtggtcc cattagg                                                    1577


<210>  6
<211>  7804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohGALNS-version2

<400>  6
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggcc gccgtggtcg ccgcaactcg atggtggcag ctgctgctgg tcctgtccgc     1980

cgctggcatg ggagcctctg gagcccctca gccccctaac atcctgctgc tgctgatgga     2040

cgatatggga tggggcgacc tgggcgtgta cggagagcca agccgggaga cacccaatct     2100

ggataggatg gcagcagagg gcctgctgtt cccaaacttt tattccgcca atcctctgtg     2160

cagcccatcc cgcgccgccc tgctgaccgg ccggctgccc atcagaaacg gcttctacac     2220

cacaaacgcc cacgcccgga atgcctatac acctcaggag atcgtgggcg gcatccccga     2280

ctctgagcag ctgctgcctg agctgctgaa gaaggccggc tacgtgagca agatcgtggg     2340

caagtggcac ctgggacaca ggccacagtt ccaccctctg aagcacggct tcgatgagtg     2400

gtttggcagc cccaattgtc actttggccc ttacgacaac aaggccagac ccaatatccc     2460

cgtgtacaga gattgggaga tggtgggcag gtactatgag gagttcccta tcaacctgaa     2520

gaccggcgag gccaatctga cacagatcta cctgcaggag gccctggact ttatcaagag     2580

gcaggcccgc caccacccct tctttctgta ctgggcagtg gatgcaaccc acgcaccagt     2640

gtatgcctct aagcccttcc tgggcacaag ccagaggggc agatatggcg acgccgtgag     2700

agagatcgac gattctatcg gcaagatcct ggagctgctg caggacctgc acgtggccga     2760

taacaccttc gtgttcttca catccgataa tggagccgcc ctgatctccg ccccagagca     2820

gggaggatct aacggaccct tcctgtgcgg caagcagacc acatttgagg gaggaatgag     2880

ggagcctgcc ctggcatggt ggccaggcca cgtgaccgcc ggccaggtga gccaccagct     2940

gggctccatc atggacctgt tcaccacaag cctggccctg gcaggcctga ccccaccatc     3000

cgacagagcc atcgatggcc tgaatctgct gcctacactg ctgcagggca ggctgatgga     3060

ccgcccaatc ttctactata ggggcgatac cctgatggca gccacactgg gacagcacaa     3120

ggcacacttt tggacctgga caaactcctg ggagaatttc cgccagggca tcgatttttg     3180

tccaggccag aacgtgtctg gcgtgaccac acacaatctg gaggaccaca ccaagctgcc     3240

cctgatcttt cacctgggcc gggatcctgg cgagagattc ccactgtctt ttgccagcgc     3300

cgagtaccag gaggccctgt cccggatcac atctgtggtg cagcagcacc aggaggccct     3360

ggtgccagca cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc     3420

aggctgtgag aaactgggca aatgtctgac tccccctgaa tctatcccta agaagtgtct     3480

gtggtcccat taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4260

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4320

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4380

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4440

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4500

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4560

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4620

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     4680

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     4740

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     4800

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     4860

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     4920

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     4980

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5040

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5100

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5160

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5220

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5280

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5340

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5400

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5460

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5520

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5580

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     5640

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     5700

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     5760

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     5820

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     5880

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     5940

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6000

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6060

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6120

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6180

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     6240

aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc     6300

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca     6360

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg     6420

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat     6480

gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg     6540

caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc     6600

aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata     6660

aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga     6720

ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt     6780

tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct     6840

atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa     6900

actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag     6960

attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat     7020

ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa     7080

tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta     7140

ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca     7200

ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat     7260

cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg     7320

agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc     7380

acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat     7440

ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa     7500

caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt     7560

tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt     7620

cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc     7680

ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt     7740

cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac     7800

gcca                                                                  7804


<210>  7
<211>  1577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS ohGALNS-version3

<400>  7
tgccaccatg gcagcggtgg tggccgcgac cagatggtgg cagcttctcc tggtcctgtc       60

ggccgcggga atgggtgcct cgggcgcgcc gcagccccct aacattctgc tgctgctgat      120

ggacgatatg ggatggggcg acctgggggt gtacggagag ccttcacggg aaacccccaa      180

cctggaccgc atggcggctg aaggcctgct gttcccgaac ttttactccg cgaatccgct      240

gtgctcccct tcgcgcgccg ccctcctgac cggacggttg cctatccgca acggcttcta      300

cactactaac gcacacgcca ggaacgccta caccccgcaa gaaattgtgg gaggaatccc      360

ggattccgaa cagctgctgc cggaactgct gaagaaggcc ggctacgtgt cgaagatcgt      420

gggaaagtgg catcttggtc atcggcctca gttccacccg ctcaagcacg ggttcgatga      480

atggttcgga tcccccaact gccactttgg cccctacgac aacaaggctc ggcctaacat      540

tcccgtctac cgggactggg aaatggtcgg aagatactac gaggagttcc ccatcaacct      600

caagactggc gaagccaacc tgactcagat ctacctccaa gaggccctgg acttcatcaa      660

gcgccaggcc cggcaccacc cgttcttcct ctattgggcg gtggacgcca cccatgcccc      720

cgtgtacgca tcaaagccgt tccttggaac tagccagaga ggcagatacg gggatgccgt      780

gcgcgaaatt gatgactcca tcggaaagat cctggagctg ctccaggacc tccatgtcgc      840

cgacaatacc ttcgtgttct ttacttccga taacggcgcc gccttgatca gcgccccgga      900

gcagggaggc tccaacggcc cttttctctg tgggaaacag accaccttcg agggagggat      960

gcgggaaccg gctctggctt ggtggcccgg acacgtgacc gccggccaag tgtcgcacca     1020

gcttggctcc atcatggact tgttcaccac ctcactggcc ctcgcggggc tcaccccacc     1080

aagcgaccga gcgattgacg gtctgaactt gctccccact ctgctgcaag gaaggctgat     1140

ggaccggccc atcttctact atcggggcga taccttgatg gccgccaccc tgggacagca     1200

caaggcccac ttttggactt ggacaaactc ctgggagaac ttccgccaag ggatcgactt     1260

ctgccccggt caaaacgtgt ccggcgtgac cacccacaac ctggaggacc ataccaagct     1320

gccactgatt ttccaccttg gtcgggaccc aggagagaga ttcccactga gcttcgcctc     1380

cgccgaatat caggaagcac tgtcccggat cacgagcgtg gtgcagcagc atcaggaggc     1440

cctggtgccg gcgcagccgc agctcaatgt ctgcaactgg gctgtgatga actgggcacc     1500

ccctggctgc gaaaaactcg ggaagtgtct gactccacct gagagcatcc cgaagaagtg     1560

cctgtggagc cactagg                                                    1577


<210>  8
<211>  7804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohGALNS-version3

<400>  8
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggca gcggtggtgg ccgcgaccag atggtggcag cttctcctgg tcctgtcggc     1980

cgcgggaatg ggtgcctcgg gcgcgccgca gccccctaac attctgctgc tgctgatgga     2040

cgatatggga tggggcgacc tgggggtgta cggagagcct tcacgggaaa cccccaacct     2100

ggaccgcatg gcggctgaag gcctgctgtt cccgaacttt tactccgcga atccgctgtg     2160

ctccccttcg cgcgccgccc tcctgaccgg acggttgcct atccgcaacg gcttctacac     2220

tactaacgca cacgccagga acgcctacac cccgcaagaa attgtgggag gaatcccgga     2280

ttccgaacag ctgctgccgg aactgctgaa gaaggccggc tacgtgtcga agatcgtggg     2340

aaagtggcat cttggtcatc ggcctcagtt ccacccgctc aagcacgggt tcgatgaatg     2400

gttcggatcc cccaactgcc actttggccc ctacgacaac aaggctcggc ctaacattcc     2460

cgtctaccgg gactgggaaa tggtcggaag atactacgag gagttcccca tcaacctcaa     2520

gactggcgaa gccaacctga ctcagatcta cctccaagag gccctggact tcatcaagcg     2580

ccaggcccgg caccacccgt tcttcctcta ttgggcggtg gacgccaccc atgcccccgt     2640

gtacgcatca aagccgttcc ttggaactag ccagagaggc agatacgggg atgccgtgcg     2700

cgaaattgat gactccatcg gaaagatcct ggagctgctc caggacctcc atgtcgccga     2760

caataccttc gtgttcttta cttccgataa cggcgccgcc ttgatcagcg ccccggagca     2820

gggaggctcc aacggccctt ttctctgtgg gaaacagacc accttcgagg gagggatgcg     2880

ggaaccggct ctggcttggt ggcccggaca cgtgaccgcc ggccaagtgt cgcaccagct     2940

tggctccatc atggacttgt tcaccacctc actggccctc gcggggctca ccccaccaag     3000

cgaccgagcg attgacggtc tgaacttgct ccccactctg ctgcaaggaa ggctgatgga     3060

ccggcccatc ttctactatc ggggcgatac cttgatggcc gccaccctgg gacagcacaa     3120

ggcccacttt tggacttgga caaactcctg ggagaacttc cgccaaggga tcgacttctg     3180

ccccggtcaa aacgtgtccg gcgtgaccac ccacaacctg gaggaccata ccaagctgcc     3240

actgattttc caccttggtc gggacccagg agagagattc ccactgagct tcgcctccgc     3300

cgaatatcag gaagcactgt cccggatcac gagcgtggtg cagcagcatc aggaggccct     3360

ggtgccggcg cagccgcagc tcaatgtctg caactgggct gtgatgaact gggcaccccc     3420

tggctgcgaa aaactcggga agtgtctgac tccacctgag agcatcccga agaagtgcct     3480

gtggagccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4260

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4320

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4380

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4440

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4500

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4560

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4620

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     4680

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     4740

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     4800

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     4860

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     4920

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     4980

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5040

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5100

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5160

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5220

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5280

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5340

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5400

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5460

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5520

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5580

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     5640

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     5700

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     5760

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     5820

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     5880

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     5940

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6000

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6060

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6120

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6180

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     6240

aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc     6300

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca     6360

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg     6420

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat     6480

gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg     6540

caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc     6600

aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata     6660

aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga     6720

ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt     6780

tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct     6840

atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa     6900

actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag     6960

attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat     7020

ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa     7080

tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta     7140

ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca     7200

ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat     7260

cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg     7320

agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc     7380

acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat     7440

ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa     7500

caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt     7560

tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt     7620

cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc     7680

ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt     7740

cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac     7800

gcca                                                                  7804


<210>  9
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS omGALNS

<400>  9
atggctgctt gtacagccgc tcagcagctg ctgctggtgc tgtctgctct gggactgctg       60

gctgctggcg ctcctcagcc tcctaacatc gtgctgctgc tgatggacga catgggctgg      120

ggcgatctgg gagtgaacgg cgagcctagc agagagacac ccaacctgga cagaatggcc      180

gccgagggca tgctgttccc cagcttctac agcgccaacc ccctgtgcag cccttctaga      240

gccgctctgc tgaccggcag actgcccatc agaaacggct tctacaccac caacgcccac      300

gccagaaacg cctacacacc ccaggaaatc atgggcggca tccccaacag cgagcatctg      360

ctgcctgagc tgctgaagaa ggccggctac accaacaaga tcgtgggcaa gtggcacctg      420

ggccacagac cccagttcca ccctctgaag cacggcttcg acgagtggtt cggcagcccc      480

aactgtcact tcggccccta cgacaacaag gccaagccca acatccccgt gtacagagac      540

tgggagatgg tgggaagatt ctacgaagag ttccccatca acagaaagac cggcgaggcc      600

aacctgaccc agctgtacac acaggaagcc ctggacttca tccagaccca gcacgccaga      660

cagagcccct tcttcctgta ctgggccatc gacgccacac acgcccctgt gtacgccagc      720

agacagttcc tgggcaccag cctgagaggc agatatggcg acgccgtgcg cgagatcgac      780

gactctgtgg gcaagatcct gtccctgctg cagaacctgg gcatcagcaa gaacaccttc      840

gtgttcttca ccagcgacaa cggcgctgcc ctgatcagcg ctcctaatga gggcggcagc      900

aacggcccat tcctgtgcgg caagcagacc acattcgagg gcggaatgag agagcccgct      960

atcgcttggt ggcctggcca tatcgctgct ggccaggtgt cacaccagct gggcagcatc     1020

atggacctgt tcaccacctc cctgagcctg gccggactga agcctcctag cgacagagtg     1080

atcgacggcc tggacctgct gcccaccatg ctgaagggcc agatgatgga cagacccatc     1140

ttctactaca gaggcaacac cctgatggcc gtgaccctgg gccagtacaa ggcccacctg     1200

tggacctgga ccaacagctg ggaagagttt acccagggca ccgatttctg ccctggccag     1260

aatgtgtccg gcgtgaccac ccacacccag gaagaacaca ccgagctgcc cctgatcttc     1320

cacctgggaa gggaccccgg cgagagattc cctctgagct tccacagcga cgagtaccag     1380

gacgccctga gcagaaccac ccaggtggtg caggaacacc agaaaagcct ggtgcccggc     1440

cagccccagc tgaacgtgtg taaccaggcc gtgatgaact gggcccctcc cggatgtgaa     1500

aagctgggaa agtgcctgac cccccctgag agcgtgcccg agaagtgttt ctgggcccac     1560

tga                                                                   1563


<210>  10
<211>  7798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-omGALNS

<400>  10
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact     1980

gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg     2040

ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat     2100

ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc     2160

tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc     2220

ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca     2280

tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca     2340

cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag     2400

ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag     2460

agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga     2520

ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc     2580

cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc     2640

cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat     2700

cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac     2760

cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg     2820

cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc     2880

cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag     2940

catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag     3000

agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc     3060

catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca     3120

cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg     3180

ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat     3240

cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta     3300

ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc     3360

cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg     3420

tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc     3480

ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct     3540

atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt     3600

ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct     3660

aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg     3720

gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt     3780

tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc     3840

agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag     3900

gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt     3960

ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg     4020

tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg     4080

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     4140

cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga     4200

gcgcgcagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     4260

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     4320

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     4380

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     4440

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     4500

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     4560

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     4620

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     4680

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     4740

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     4800

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     4860

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag     4920

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     4980

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     5040

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     5100

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     5160

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     5220

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg     5280

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac     5340

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg     5400

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc     5460

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta     5520

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac     5580

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc     5640

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac     5700

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact     5760

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa     5820

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt     5880

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca     5940

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa     6000

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac     6060

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     6120

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     6180

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata     6240

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     6300

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     6360

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     6420

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa     6480

ggagaaaata ccgcatcagg cgattccaac atccaataaa tcatacaggc aaggcaaaga     6540

attagcaaaa ttaagcaata aagcctcaga gcataaagct aaatcggttg taccaaaaac     6600

attatgaccc tgtaatactt ttgcgggaga agcctttatt tcaacgcaag gataaaaatt     6660

tttagaaccc tcatatattt taaatgcaat gcctgagtaa tgtgtaggta aagattcaaa     6720

cgggtgagaa aggccggaga cagtcaaatc accatcaata tgatattcaa ccgttctagc     6780

tgataaattc atgccggaga gggtagctat ttttgagagg tctctacaaa ggctatcagg     6840

tcattgcctg agagtctgga gcaaacaaga gaatcgatga acggtaatcg taaaactagc     6900

atgtcaatca tatgtacccc ggttgataat cagaaaagcc ccaaaaacag gaagattgta     6960

taagcaaata tttaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt     7020

taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa     7080

gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag     7140

aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt     7200

gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac     7260

cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag     7320

gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg     7380

cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc     7440

tttgacgagc acgtataacg tgctttcctc gttagaatca gagcgggagc taaacaggag     7500

gccgattaaa gggattttag acaggaacgg tacgccagaa tcctgagaag tgtttttata     7560

atcagtgagg ccaccgagta aaagagtctg tccatcacgc aaattaaccg ttgtcgcaat     7620

acttctttga ttagtaataa catcacttgc ctgagtagaa gaactcaaac tatcggcctt     7680

gctggtaata tccagaacaa tattaccgcc agccattgca acggaatcgc cattcgccat     7740

tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgcca       7798


<210>  11
<211>  7438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-hAAT-omGALNS

<400>  11
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagg atctgatatc atcgatgaat tcgagctcgg tacccggccg cagatttagg      240

tgacactata gaatatgcat cactagtaag cttgcgaatt ccagtctaca gagaggtctc      300

tgacctctgc cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct      360

gcttgcaatg tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact      420

tcagaggcag cacacaaaca gcaagcttgc gaattccagt ctacagagag gtctctgacc      480

tctgccccag ctccaaggtc agcaggcagg gagggctgtg tgtttgctgt ttgctgcttg      540

caatgtttgc ccattttagg gacatgagta ggctgaagtt tgttcagtgt ggacttcaga      600

ggcagcacac aaacagcaag cttgcgaatt ccagtctaca gagaggtctc tgacctctgc      660

cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct gcttgcaatg      720

tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact tcagaggcag      780

cacacaaaca gcaagctttg ctctagactg gaattcgtcg acgagctccc tatagtgagt      840

cgtattagag gccgactgac ccggtacccg gggatcttgc taccagtgga acagccacta      900

aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac      960

tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacaatga     1020

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt     1080

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg     1140

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct     1200

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg     1260

acagtgaatg tccccctgat ctgcggccgt gactctctta aggtagcctt gcagaagttg     1320

gtcgtgaggc actgggcagg taagtatcaa ggttacaaga caggtttaag gagaccaata     1380

gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct     1440

tactgacatc cactttgcct ttctctccac aggtgtccac tcccagttca attacagctc     1500

ttaaggctag agtacttaat acgactcact ataggctagc ctcgacctcg agacgcgtgc     1560

caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact     1620

gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg     1680

ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat     1740

ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc     1800

tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc     1860

ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca     1920

tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca     1980

cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag     2040

ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag     2100

agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga     2160

ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc     2220

cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc     2280

cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat     2340

cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac     2400

cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg     2460

cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc     2520

cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag     2580

catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag     2640

agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc     2700

catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca     2760

cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg     2820

ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat     2880

cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta     2940

ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc     3000

cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg     3060

tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc     3120

ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct     3180

atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt     3240

ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct     3300

aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg     3360

gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt     3420

tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc     3480

agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag     3540

gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt     3600

ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg     3660

tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg     3720

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     3780

cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga     3840

gcgcgcagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     3900

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     3960

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     4020

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     4080

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     4140

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     4200

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     4260

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     4320

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     4380

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     4440

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     4500

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag     4560

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     4620

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     4680

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     4740

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     4800

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     4860

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg     4920

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac     4980

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg     5040

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc     5100

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta     5160

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac     5220

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc     5280

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac     5340

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact     5400

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa     5460

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt     5520

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca     5580

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa     5640

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac     5700

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     5760

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     5820

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata     5880

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     5940

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     6000

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     6060

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa     6120

ggagaaaata ccgcatcagg cgattccaac atccaataaa tcatacaggc aaggcaaaga     6180

attagcaaaa ttaagcaata aagcctcaga gcataaagct aaatcggttg taccaaaaac     6240

attatgaccc tgtaatactt ttgcgggaga agcctttatt tcaacgcaag gataaaaatt     6300

tttagaaccc tcatatattt taaatgcaat gcctgagtaa tgtgtaggta aagattcaaa     6360

cgggtgagaa aggccggaga cagtcaaatc accatcaata tgatattcaa ccgttctagc     6420

tgataaattc atgccggaga gggtagctat ttttgagagg tctctacaaa ggctatcagg     6480

tcattgcctg agagtctgga gcaaacaaga gaatcgatga acggtaatcg taaaactagc     6540

atgtcaatca tatgtacccc ggttgataat cagaaaagcc ccaaaaacag gaagattgta     6600

taagcaaata tttaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt     6660

taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa     6720

gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag     6780

aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt     6840

gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac     6900

cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag     6960

gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg     7020

cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc     7080

tttgacgagc acgtataacg tgctttcctc gttagaatca gagcgggagc taaacaggag     7140

gccgattaaa gggattttag acaggaacgg tacgccagaa tcctgagaag tgtttttata     7200

atcagtgagg ccaccgagta aaagagtctg tccatcacgc aaattaaccg ttgtcgcaat     7260

acttctttga ttagtaataa catcacttgc ctgagtagaa gaactcaaac tatcggcctt     7320

gctggtaata tccagaacaa tattaccgcc agccattgca acggaatcgc cattcgccat     7380

tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgcca       7438


<210>  12
<211>  4215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-hGALNS

<400>  12
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggcg gcggttgtcg cggcgacgag gtggtggcag ctgttgctgg tgctcagcgc     1980

cgcggggatg ggggcctcgg gcgccccgca gccccccaac atcctgctcc tgctcatgga     2040

cgacatggga tggggtgacc tcggggtgta tggagagccc tccagagaga ccccgaattt     2100

ggaccggatg gctgcagaag ggctgctttt cccaaacttc tattctgcca accctctgtg     2160

ctcgccatcg agggcggcac tgctcacagg acggctaccc atccgcaatg gcttctacac     2220

caccaacgcc catgccagaa acgcctacac accgcaggag attgtgggcg gcatcccaga     2280

ctcggagcag ctcctgccgg agcttctgaa gaaggccggc tacgtcagca agattgtcgg     2340

caagtggcat ctgggtcaca ggccccagtt ccaccccctg aagcacggat ttgatgagtg     2400

gtttggatcc cccaactgcc actttggacc ttatgacaac aaggccaggc ccaacatccc     2460

tgtgtacagg gactgggaga tggttggcag atattatgaa gaatttccta ttaatctgaa     2520

gacgggggaa gccaacctca cccagatcta cctgcaggaa gccctggact tcattaagag     2580

acaggcacgg caccacccct ttttcctcta ctgggctgtc gacgccacgc acgcacccgt     2640

ctatgcctcc aaacccttct tgggcaccag tcagcgaggg cggtatggag acgccgtccg     2700

ggagattgat gacagcattg ggaagatact ggagctcctc caagacctgc acgtcgcgga     2760

caacaccttc gtcttcttca cgtcggacaa cggcgctgcc ctcatttccg cccccgaaca     2820

aggtggcagc aacggcccct ttctgtgtgg gaagcagacc acgtttgaag gagggatgag     2880

ggagcctgcc ctcgcatggt ggccagggca cgtcactgca ggccaggtga gccaccagct     2940

gggcagcatc atggacctct tcaccaccag cctggccctt gcgggcctga cgccgcccag     3000

cgacagggcc attgatggcc tcaacctcct ccccaccctc ctgcagggcc ggctgatgga     3060

caggcctatc ttctattacc gtggcgacac gctgatggcg gccaccctcg ggcagcacaa     3120

ggctcacttc tggacctgga ccaactcctg ggagaacttc agacagggca ttgatttctg     3180

ccctgggcag aacgtttcag gggtcacaac tcacaatctg gaagaccaca cgaagctgcc     3240

cctgatcttc cacctgggac gggacccagg ggagaggttc cccctcagct ttgccagcgc     3300

cgagtaccag gaggccctca gcaggatcac ctcggtcgtc cagcagcacc aggaggcctt     3360

ggtccccgcg cagccccagc tcaacgtgtg caactgggcg gtcatgaact gggcacctcc     3420

gggctgtgaa aagttaggga agtgtctgac acctccagaa tccattccca agaagtgcct     3480

ctggtcccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagc                                                      4215


<210>  13
<211>  4215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohGALNS-version1

<400>  13
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggct gctgtggtgg ctgccacaag atggtggcag ctgctgctgg tgctgagcgc     1980

cgctggaatg ggagcttctg gcgctcccca gccccccaat attctcctgc tgctgatgga     2040

cgacatgggc tggggcgatc tgggagtgta cggcgagcct agcagagaga cacccaacct     2100

ggacagaatg gccgccgagg gcctgctgtt ccccaacttc tacagcgcca accccctgtg     2160

cagcccatct agagccgctc tgctgaccgg cagactgccc atcagaaacg gcttctacac     2220

caccaacgcc cacgcccgga acgcctacac accccaggaa atcgtgggcg gcatccccga     2280

tagcgaacag ctgctgcctg agctgctgaa gaaagccggc tacgtgtcca agatcgtggg     2340

caagtggcac ctgggccaca gaccccagtt ccaccctctg aagcacggct tcgacgagtg     2400

gttcggcagc cccaattgcc acttcggccc ctacgacaac aaggccagac ccaacatccc     2460

cgtgtaccgg gactgggaga tggtgggacg gtactacgaa gagttcccca tcaacctgaa     2520

aaccggcgag gccaacctga cccagatcta cctgcaggaa gccctggact tcatcaagcg     2580

gcaggcccgg caccaccctt tctttctgta ctgggccgtg gacgccaccc acgcccctgt     2640

gtatgccagc aagcctttcc tgggcaccag ccagagaggc agatacggcg acgccgtgcg     2700

cgagatcgat gacagcatcg gcaagatcct ggaactgctg caggacctgc acgtggccga     2760

caacaccttc gtgttcttca ccagcgacaa cggcgctgcc ctgatctctg ctcctgagca     2820

gggcggcagc aacggcccat ttctgtgtgg caagcagacc accttcgagg gcggcatgag     2880

agaacctgcc ctggcttggt ggcctggcca tgtgacagct ggacaggtgt cccaccagct     2940

gggcagcatc atggacctgt tcaccaccag cctggccctg gccggactga cacctccaag     3000

cgacagagcc atcgacggcc tgaacctgct gcctaccctg ctgcagggac ggctgatgga     3060

ccggcccatc ttctactaca gaggcgacac cctgatggcc gccacactgg gacagcacaa     3120

ggcccacttt tggacctgga ccaacagctg ggagaacttc cggcagggca tcgacttttg     3180

ccctggccag aatgtgtccg gcgtgaccac ccacaacctg gaagatcaca ccaagctgcc     3240

cctgattttc cacctgggca gagatcccgg cgagcggttc cctctgtctt ttgccagcgc     3300

cgagtaccag gaagctctga gcagaatcac ctccgtggtg cagcagcacc aggaagcact     3360

ggtgcctgct cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc     3420

cggctgtgaa aagctgggaa agtgcctgac cccccctgag agcatcccca agaaatgcct     3480

gtggtcccac tgagaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagc                                                      4215


<210>  14
<211>  4215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohGALNS-version2

<400>  14
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggcc gccgtggtcg ccgcaactcg atggtggcag ctgctgctgg tcctgtccgc     1980

cgctggcatg ggagcctctg gagcccctca gccccctaac atcctgctgc tgctgatgga     2040

cgatatggga tggggcgacc tgggcgtgta cggagagcca agccgggaga cacccaatct     2100

ggataggatg gcagcagagg gcctgctgtt cccaaacttt tattccgcca atcctctgtg     2160

cagcccatcc cgcgccgccc tgctgaccgg ccggctgccc atcagaaacg gcttctacac     2220

cacaaacgcc cacgcccgga atgcctatac acctcaggag atcgtgggcg gcatccccga     2280

ctctgagcag ctgctgcctg agctgctgaa gaaggccggc tacgtgagca agatcgtggg     2340

caagtggcac ctgggacaca ggccacagtt ccaccctctg aagcacggct tcgatgagtg     2400

gtttggcagc cccaattgtc actttggccc ttacgacaac aaggccagac ccaatatccc     2460

cgtgtacaga gattgggaga tggtgggcag gtactatgag gagttcccta tcaacctgaa     2520

gaccggcgag gccaatctga cacagatcta cctgcaggag gccctggact ttatcaagag     2580

gcaggcccgc caccacccct tctttctgta ctgggcagtg gatgcaaccc acgcaccagt     2640

gtatgcctct aagcccttcc tgggcacaag ccagaggggc agatatggcg acgccgtgag     2700

agagatcgac gattctatcg gcaagatcct ggagctgctg caggacctgc acgtggccga     2760

taacaccttc gtgttcttca catccgataa tggagccgcc ctgatctccg ccccagagca     2820

gggaggatct aacggaccct tcctgtgcgg caagcagacc acatttgagg gaggaatgag     2880

ggagcctgcc ctggcatggt ggccaggcca cgtgaccgcc ggccaggtga gccaccagct     2940

gggctccatc atggacctgt tcaccacaag cctggccctg gcaggcctga ccccaccatc     3000

cgacagagcc atcgatggcc tgaatctgct gcctacactg ctgcagggca ggctgatgga     3060

ccgcccaatc ttctactata ggggcgatac cctgatggca gccacactgg gacagcacaa     3120

ggcacacttt tggacctgga caaactcctg ggagaatttc cgccagggca tcgatttttg     3180

tccaggccag aacgtgtctg gcgtgaccac acacaatctg gaggaccaca ccaagctgcc     3240

cctgatcttt cacctgggcc gggatcctgg cgagagattc ccactgtctt ttgccagcgc     3300

cgagtaccag gaggccctgt cccggatcac atctgtggtg cagcagcacc aggaggccct     3360

ggtgccagca cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc     3420

aggctgtgag aaactgggca aatgtctgac tccccctgaa tctatcccta agaagtgtct     3480

gtggtcccat taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagc                                                      4215


<210>  15
<211>  4215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohGALNS-version3

<400>  15
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggca gcggtggtgg ccgcgaccag atggtggcag cttctcctgg tcctgtcggc     1980

cgcgggaatg ggtgcctcgg gcgcgccgca gccccctaac attctgctgc tgctgatgga     2040

cgatatggga tggggcgacc tgggggtgta cggagagcct tcacgggaaa cccccaacct     2100

ggaccgcatg gcggctgaag gcctgctgtt cccgaacttt tactccgcga atccgctgtg     2160

ctccccttcg cgcgccgccc tcctgaccgg acggttgcct atccgcaacg gcttctacac     2220

tactaacgca cacgccagga acgcctacac cccgcaagaa attgtgggag gaatcccgga     2280

ttccgaacag ctgctgccgg aactgctgaa gaaggccggc tacgtgtcga agatcgtggg     2340

aaagtggcat cttggtcatc ggcctcagtt ccacccgctc aagcacgggt tcgatgaatg     2400

gttcggatcc cccaactgcc actttggccc ctacgacaac aaggctcggc ctaacattcc     2460

cgtctaccgg gactgggaaa tggtcggaag atactacgag gagttcccca tcaacctcaa     2520

gactggcgaa gccaacctga ctcagatcta cctccaagag gccctggact tcatcaagcg     2580

ccaggcccgg caccacccgt tcttcctcta ttgggcggtg gacgccaccc atgcccccgt     2640

gtacgcatca aagccgttcc ttggaactag ccagagaggc agatacgggg atgccgtgcg     2700

cgaaattgat gactccatcg gaaagatcct ggagctgctc caggacctcc atgtcgccga     2760

caataccttc gtgttcttta cttccgataa cggcgccgcc ttgatcagcg ccccggagca     2820

gggaggctcc aacggccctt ttctctgtgg gaaacagacc accttcgagg gagggatgcg     2880

ggaaccggct ctggcttggt ggcccggaca cgtgaccgcc ggccaagtgt cgcaccagct     2940

tggctccatc atggacttgt tcaccacctc actggccctc gcggggctca ccccaccaag     3000

cgaccgagcg attgacggtc tgaacttgct ccccactctg ctgcaaggaa ggctgatgga     3060

ccggcccatc ttctactatc ggggcgatac cttgatggcc gccaccctgg gacagcacaa     3120

ggcccacttt tggacttgga caaactcctg ggagaacttc cgccaaggga tcgacttctg     3180

ccccggtcaa aacgtgtccg gcgtgaccac ccacaacctg gaggaccata ccaagctgcc     3240

actgattttc caccttggtc gggacccagg agagagattc ccactgagct tcgcctccgc     3300

cgaatatcag gaagcactgt cccggatcac gagcgtggtg cagcagcatc aggaggccct     3360

ggtgccggcg cagccgcagc tcaatgtctg caactgggct gtgatgaact gggcaccccc     3420

tggctgcgaa aaactcggga agtgtctgac tccacctgag agcatcccga agaagtgcct     3480

gtggagccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg     3540

ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     3780

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     3840

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     3900

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     3960

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     4020

tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc     4200

gagcgagcgc gcagc                                                      4215


<210>  16
<211>  4209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-omGALNS/ AAV8-CAG-omGALNS

<400>  16
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      240

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      300

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      360

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      420

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      480

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      540

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      600

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      660

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      720

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      780

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      840

gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac      900

tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt      960

agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc     1020

tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg     1140

cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc     1200

ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     1260

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc     1920

caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact     1980

gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg     2040

ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat     2100

ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc     2160

tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc     2220

ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca     2280

tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca     2340

cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag     2400

ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag     2460

agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga     2520

ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc     2580

cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc     2640

cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat     2700

cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac     2760

cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg     2820

cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc     2880

cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag     2940

catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag     3000

agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc     3060

catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca     3120

cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg     3180

ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat     3240

cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta     3300

ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc     3360

cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg     3420

tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc     3480

ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct     3540

atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt     3600

ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct     3660

aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg     3720

gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt     3780

tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc     3840

agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag     3900

gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt     3960

ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg     4020

tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg     4080

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     4140

cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga     4200

gcgcgcagc                                                             4209


<210>  17
<211>  3849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV8-hAAT-omGALNS

<400>  17
gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt       60

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac      120

taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt      180

attgactagg atctgatatc atcgatgaat tcgagctcgg tacccggccg cagatttagg      240

tgacactata gaatatgcat cactagtaag cttgcgaatt ccagtctaca gagaggtctc      300

tgacctctgc cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct      360

gcttgcaatg tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact      420

tcagaggcag cacacaaaca gcaagcttgc gaattccagt ctacagagag gtctctgacc      480

tctgccccag ctccaaggtc agcaggcagg gagggctgtg tgtttgctgt ttgctgcttg      540

caatgtttgc ccattttagg gacatgagta ggctgaagtt tgttcagtgt ggacttcaga      600

ggcagcacac aaacagcaag cttgcgaatt ccagtctaca gagaggtctc tgacctctgc      660

cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct gcttgcaatg      720

tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact tcagaggcag      780

cacacaaaca gcaagctttg ctctagactg gaattcgtcg acgagctccc tatagtgagt      840

cgtattagag gccgactgac ccggtacccg gggatcttgc taccagtgga acagccacta      900

aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac      960

tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacaatga     1020

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt     1080

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg     1140

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct     1200

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg     1260

acagtgaatg tccccctgat ctgcggccgt gactctctta aggtagcctt gcagaagttg     1320

gtcgtgaggc actgggcagg taagtatcaa ggttacaaga caggtttaag gagaccaata     1380

gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct     1440

tactgacatc cactttgcct ttctctccac aggtgtccac tcccagttca attacagctc     1500

ttaaggctag agtacttaat acgactcact ataggctagc ctcgacctcg agacgcgtgc     1560

caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact     1620

gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg     1680

ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat     1740

ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc     1800

tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc     1860

ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca     1920

tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca     1980

cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag     2040

ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag     2100

agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga     2160

ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc     2220

cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc     2280

cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat     2340

cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac     2400

cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg     2460

cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc     2520

cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag     2580

catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag     2640

agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc     2700

catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca     2760

cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg     2820

ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat     2880

cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta     2940

ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc     3000

cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg     3060

tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc     3120

ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct     3180

atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt     3240

ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct     3300

aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg     3360

gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt     3420

tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc     3480

agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag     3540

gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt     3600

ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg     3660

tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg     3720

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     3780

cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga     3840

gcgcgcagc                                                             3849


<210>  18
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG Promoter

<400>  18
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      840

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg      900

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc      960

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc     1080

gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc     1320

tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag     1380

ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc     1440

tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc     1500

cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg     1560

ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc     1620

ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct acag           1674


<210>  19
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAAT Promoter

<400>  19
gatctgatat catcgatgaa ttcgagctcg gtacccggcc gcagatttag gtgacactat       60

agaatatgca tcactagtaa gcttgcgaat tccagtctac agagaggtct ctgacctctg      120

ccccagctcc aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat      180

gtttgcccat tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca      240

gcacacaaac agcaagcttg cgaattccag tctacagaga ggtctctgac ctctgcccca      300

gctccaaggt cagcaggcag ggagggctgt gtgtttgctg tttgctgctt gcaatgtttg      360

cccattttag ggacatgagt aggctgaagt ttgttcagtg tggacttcag aggcagcaca      420

caaacagcaa gcttgcgaat tccagtctac agagaggtct ctgacctctg ccccagctcc      480

aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat gtttgcccat      540

tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca gcacacaaac      600

agcaagcttt gctctagact ggaattcgtc gacgagctcc ctatagtgag tcgtattaga      660

ggccgactga cccggtaccc ggggatcttg ctaccagtgg aacagccact aaggattctg      720

cagtgagagc agagggccag ctaagtggta ctctcccaga gactgtctga ctcacgccac      780

cccctccacc ttggacacag gacgctgtgg tttctgagcc aggtacaatg actcctttcg      840

gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg taggcgggcg      900

actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact ggggtgacct      960

tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc ttaaatacgg     1020

acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg gacagtgaat     1080

gtccccctga tctgcggccg tgactctctt aaggtagcct tgcagaagtt ggtcgtgagg     1140

cactgggcag gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg     1200

cttgtcgaga cagagaagac t                                               1221


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer

<400>  20
ccagggaatg tcccacctat tt                                                22


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense primer

<400>  21
gtcaggttga cacgaagctg                                                   20


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense primer KO

<400>  22
ggaacttcgg ttccggcg                                                     18


