                         SEQUENCE LISTING

<110>  Shenzhen Geno-Immune Medical Institute
 
<120>  LENTIVIRAL VECTOR USED FOR THE TREATMENT OF HEMOPHILIA A, 
       LENTIVIRUS, AND PREPARATION METHOD AND APPLICATION THEREOF

<130>  PCT190338PPC

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  7056
<212>  DNA
<213>  Artificial Sequence

<400>  1
atgcagatcg aactgagcac ctgcttcttc ctgtgtctcc tgagattctg ctttagtgct     60

accagacggt attacctggg agccgtcgag ctgagttggg attacatgca gtccgacctc    120

ggagaactgc ctgtggatgc acgctttcca ccaagagtgc ctaagtcatt cccattcaac    180

acctcagtcg tgtataagaa gactctgttc gtcgagttta ctgatcacct gttcaatatc    240

gctaaaccta gaccaccctg gatgggactg ctgggtccta caatccaggc agaggtctat    300

gacactgtgg tgattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt    360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg    420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg    480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat    540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa    600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta    660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat    720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct    780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc    840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat    900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg    960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa   1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa   1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat   1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact   1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc   1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg   1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct   1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg   1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact   1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt   1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca   1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga   1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa   1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag   1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg   1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt   1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc   1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa   2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg   2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc   2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac   2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc   2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt   2340

ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa   2400

atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat   2460

gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca   2520

cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc   2580

catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag   2640

aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca   2700

tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca   2760

agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta   2820

tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa   2880

aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga   2940

aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct   3000

gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac   3060

aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta   3120

attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa   3180

gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta   3240

aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa   3300

gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc   3360

ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg   3420

caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag   3480

aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta   3540

ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat   3600

ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag   3660

gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag   3720

aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac   3780

ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca   3840

aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga   3900

aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca   3960

agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca   4020

ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc   4080

aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag   4140

aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct   4200

caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct   4260

atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat   4320

agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat   4380

aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc   4440

ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg   4500

aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat   4560

cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg   4620

gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct   4680

ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta   4740

ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa   4800

tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg   4860

aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa   4920

atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca   4980

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa   5040

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat   5100

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct   5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg   5220

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc   5280

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca   5340

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt   5400

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa   5460

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat   5520

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt   5580

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac   5640

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc   5700

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct   5760

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc   5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga   5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat   5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt   6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt   6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt   6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga   6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc   6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt   6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt   6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga   6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac   6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact   6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag   6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc   6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct   6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca   6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc   6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag   6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta   6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg   7020

gaggttctgg gctgcgaggc acaggacctc tactga                             7056


<210>  2
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<400>  2
atgcagatcg aactgagcac ctgcttcttc ctgtgtctcc tgagattctg ctttagtgct     60

accagacggt attacctggg agccgtcgag ctgagttggg attacatgca gtccgacctc    120

ggagaactgc ctgtggatgc acgctttcca ccaagagtgc ctaagtcatt cccattcaac    180

acctcagtcg tgtataagaa gactctgttc gtcgagttta ctgatcacct gttcaatatc    240

gctaaaccta gaccaccctg gatgggactg ctgggtccta caatccaggc agaggtctat    300

gacactgtgg tgattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt    360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg    420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg    480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat    540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa    600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta    660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat    720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct    780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc    840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat    900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg    960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa   1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa   1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat   1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact   1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc   1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg   1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct   1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg   1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact   1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt   1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca   1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga   1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa   1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag   1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg   1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt   1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc   1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa   2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg   2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc   2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac   2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc   2280

ttttctcaga atcctcctgt cctcaaacgc catcaacggg agattacacg gaccacactc   2340

caaagcgatc aggaggagat cgactatgac gataccatat ctgtggaaat gaagaaagag   2400

gacttcgaca tctacgacga agatgagaac caaagtccaa gatccttcca gaagaagact   2460

aggcactact tcatcgctgc cgtggaacgc ctctgggatt acggaatgtc cagttctcca   2520

catgtcctca ggaatagggc acagtctggc tctgttccac agtttaagaa agttgtcttt   2580

caggagttca cagatggctc attcactcaa ccactgtata gaggcgaact gaatgagcac   2640

ctgggactgc tgggtcccta catcagagcc gaagtggagg ataacattat ggtcaccttt   2700

cggaaccaag cctccaggcc atacagtttc tacagttctc tgatctcata cgaggaagat   2760

cagaggcaag gagcagaacc aaggaagaac ttcgtgaaac caaacgagac aaagacctat   2820

ttctggaaag ttcagcatca tatggcaccc actaaagatg agtttgactg caaagcctgg   2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt   2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa   3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg   3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat   3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct   3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct   3240

attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg   3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt   3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg   3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt   3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat   3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg   3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc   3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat   3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata   3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat   3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc   3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac   3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg   4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag   4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg   4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt   4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac   4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac   4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta ctga         4374


<210>  3
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<400>  3
gcggccgcta gcatgcctag gtcgaccaat tctcatgttt gacagcttat catcgataag     60

ctttggagct aagccagcaa tggtagaggg aagattctgc acgtcccttc caggcggcct    120

ccccgtcacc acccccccca acccgccccg accggagctg agagtaattc atacaaaagg    180

actcgcccct gccttgggga atcccaggga ccgtcgttaa actcccacta acgtagaacc    240

cagagatcgc tgcgttcccg ccccctcacc cgcccgctct cgtcatcact gaggtggaga    300

agagcatgcg tgaggctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc    360

cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaagt ggcgcggggt    420

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc    480

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac    540

acaggtaagt gccgtgtgtg gttcccgcgg gcctggcctc tttacgggtt atggcccttg    600

cgtgccttga attacttcca cgcccctggc tgcagtacgt gattcttgat cccgagcttc    660

gggttggaag tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg    720

cttgagttga ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc    780

gcgcctgtct cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg    840

cgacgctttt tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta    900

tttcggtttt tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg    960

cgaggcgggg cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc   1020

ggcctgctct ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc   1080

tggcccggtc ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag   1140

ggagctcaaa atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa   1200

ggaaaagggc ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc   1260

cgtccaggca cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg   1320

aggggtttta tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag   1380

cttggcactt gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca   1440

ttctcaagcc tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgaaaac   1500

tctagagcgg ccgcggaggc cgaattccgt cga                                1533


<210>  4
<211>  60
<212>  DNA
<213>  Artificial Sequence

<400>  4
ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta     60


<210>  5
<211>  60
<212>  DNA
<213>  Artificial Sequence

<400>  5
ggcaagaggc gaggggcggc gactgcagag tacgccaaaa attttgacta gcggaggcta     60


<210>  6
<211>  60
<212>  DNA
<213>  Artificial Sequence

<400>  6
ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta     60


<210>  7
<211>  60
<212>  DNA
<213>  Artificial Sequence

<400>  7
ggcaagaggc gaggggcggc gactggggag tacgccaaaa attttgacta gcggaggcta     60


