                         SEQUENCE LISTING

<110>  Temple University-Of the Commonwealth System of Higher 
       Education
       Lankenau Institute of Medical Research
       Wilson, Cagla
       Dessain, Scott
 
<120>  ERADICATION OF BACTERIAL BIOFILM USING ANTI-AMYLOID MONOCLONAL 
       ANTIBODIES

<130>  206017-0178-00WO

<150>  US 62/676,390
<151>  2018-05-25

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.3H3 Heavy Chain

<400>  1
atggagtttg ggctgagctg ggtattcctc gttgctcttt taagaggtgt ccagtgtcaa       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcct ctggattctc cttcagtacc tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttatt tcatatgatg gaagtaggaa atactatgca      240

gacaccggga agggccgatt caccatctcc agagacaact ccaagaacac gctgtatttg      300

gaaatgaacg gcctgagagc tgaagacacg gctgtgtatc actgtgcgaa agatcttaga      360

cgagaactcg ggtttggcaa tcgggactat cactattatg gtatggacgc ctggggccaa      420

gggaccacgg tcaccgtctc ctcagcaagc accaagg                               457


<210>  2
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.3H3 Heavy Chain

<400>  2

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Ser Thr Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Arg Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Gly Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr His Cys Ala Lys Asp Leu Arg Arg Glu Leu Gly Phe Gly Asn Arg 
        115                 120                 125             


Asp Tyr His Tyr Tyr Gly Met Asp Ala Trp Gly Gln Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys 
145                 150         


<210>  3
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.3H3 Heavy Chain variable region

<400>  3
caagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atttcatatg atggaagtag gaaatactat      180

gcagacaccg ggaagggccg attcaccatc tccagagaca actccaagaa cacgctgtat      240

ttggaaatga acggcctgag agctgaagac acggctgtgt atcactgtgc gaaagatctt      300

agacgagaac tcgggtttgg caatcgggac tatcactatt atggtatgga cgcctggggc      360

caagggacca cggtcaccgt ctcctcagca agcaccaagg                            400


<210>  4
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.3H3 Heavy Chain variable region

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Thr Gly 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Arg Glu Leu Gly Phe Gly Asn Arg Asp Tyr His 
            100                 105                 110         


Tyr Tyr Gly Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  5
<211>  461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Heavy Chain (nucleotide) with 4nt before 
       the Met

<400>  5
cgccatggag tttgggctga gctgggtatt cctcgttgct cttttaagag gtgtccagtg       60

tcaagtgcag ctggtggagt ctgggggagg cgtggtccag cctgggaggt ccctgagact      120

ctcctgtgca gcctctggat tctccttcag tacctatggc atgcactggg tccgccaggc      180

tccaggcaag gggctggagt gggtggcagt tatttcatat gatggaagta ggaaatacta      240

tgcagacacc gggaagggcc gattcaccat ctccagagac aactccaaga acacgctgta      300

tttggaaatg aacggcctga gagctgaaga cacggctgtg tatcactgtg cgaaagatct      360

tagacgagaa ctcgggtttg gcaatcggga ctatcactat tatggtatgg acgcctgggg      420

ccaagggacc acggtcaccg tctcctcagc aagcaccaag g                          461


<210>  6
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR1

<400>  6
caagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctct                                                        75


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR1

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR1

<400>  8
ggattctcct tcagtaccta tggc                                              24


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR1

<400>  9

Gly Phe Ser Phe Ser Thr Tyr Gly 
1               5               


<210>  10
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR2

<400>  10
atgcactggg tccgccaggc tccaggcaag gggctggagt gggtggcagt t                51


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR2

<400>  11

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Val 
    


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR2

<400>  12
atttcatatg atggaagtag gaaa                                              24


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR2

<400>  13

Ile Ser Tyr Asp Gly Ser Arg Lys 
1               5               


<210>  14
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR3

<400>  14
tactatgcag acaccgggaa gggccgattc accatctcca gagacaactc caagaacacg       60

ctgtatttgg aaatgaacgg cctgagagct gaagacacgg ctgtgtatca ctgt            114


<210>  15
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR3

<400>  15

Tyr Tyr Ala Asp Thr Gly Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Glu Met Asn Gly Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr His Cys 
        35              


<210>  16
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR3

<400>  16
gcgaaagatc ttagacgaga actcgggttt ggcaatcggg actatcacta ttatggtatg       60

gacgcc                                                                  66


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR3

<400>  17

Ala Lys Asp Leu Arg Arg Glu Leu Gly Phe Gly Asn Arg Asp Tyr His 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Ala 
            20          


<210>  18
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, JUNCTION

<400>  18
tgtgcgaaag atcttagacg agaactcggg tttggcaatc gggactatca ctattatggt       60

atggacgcct gg                                                           72


<210>  19
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, JUNCTION

<400>  19

Cys Ala Lys Asp Leu Arg Arg Glu Leu Gly Phe Gly Asn Arg Asp Tyr 
1               5                   10                  15      


His Tyr Tyr Gly Met Asp Ala Trp 
            20                  


<210>  20
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3'V-REGION

<400>  20
tgtgcgaaag a                                                            11


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3'V-REGION

<400>  21

Cys Ala Lys 
1           


<210>  22
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, N1-REGION

<400>  22
tcttagacga ga                                                           12


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, N1-REGION

<400>  23

Leu Arg Arg 
1           


<210>  24
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, D-REGION

<400>  24
actcgggttt gg                                                           12


<210>  25
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, D-REGION

<400>  25

Leu Gly Phe 
1           


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, N2-REGION

<400>  26
caatcgggac tatcactat                                                    19


<210>  27
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, N2-REGION


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  27
nrdyhy                                                                   6


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 5'J-REGION

<400>  28
tatggtatgg acgcctgg                                                     18


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 5'J-REGION

<400>  29

Tyr Gly Met Asp Ala Trp 
1               5       


<210>  30
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, J-REGION

<400>  30
tatggtatgg acgcctgggg ccaagggacc acggtcaccg tctcctca                    48


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, J-REGION

<400>  31

Tyr Gly Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10                  15      


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR4

<400>  32
tggggccaag ggaccacggt caccgtctcc tca                                    33


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR4

<400>  33

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  34
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.3H3 Light Chain

<400>  34
gctgactcag cctcgctcag tgtccgggtc tcctggacag tcagtaacca tgtcctgcac       60

tggaaccaac agtgatattg gtggttataa ttatgtctcc tggtaccaac aacacccagg      120

caaagccccc aaactcatga tttatgatgt ctataagcgg ccctcagggg tccctgatcg      180

cttctctggc tccaagtctg gcaacacggc ctccctgacc atctctgggc tccaggctga      240

ggatgaggct gattactact gctgctcata tgcaggcacc aacaatttga tattcggcgg      300

agggaccaag ctgaccgtcc taggtcagcc caaggctgcc ccctcggtca ctctgttccc      360

gccctcctct gaggagcttc aagccaacaa ggccacactg gtgtgtctca taagtgactt      420

ctacccggga gccgtgacag tggcctggaa ggcagatagc agccccgtca aggcgggagt      480

ggagaccacc acaccctcca aacaaagcaa caacaagtac gcggccagca gctatctgag      540

cctgacgcct gagcagtgga agtcccacag aagctacagc tgccaggtca c               591


<210>  35
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.3H3 Light Chain

<400>  35

Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr 
1               5                   10                  15      


Met Ser Cys Thr Gly Thr Asn Ser Asp Ile Gly Gly Tyr Asn Tyr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
        35                  40                  45              


Asp Val Tyr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr Asn Asn Leu 
                85                  90                  95      


Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val 
        195     


<210>  36
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR1

<400>  36
gctgactcag cctcgctcag tgtccgggtc tcctggacag tcagtaacca tgtcctgcac       60

tggaacc                                                                 67


<210>  37
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR1

<400>  37

Ala Asp Ser Ala Ser Leu Ser Val Arg Val Ser Trp Thr Val Ser Asn 
1               5                   10                  15      


His Val Leu His Trp Asn 
            20          


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR1

<400>  38
aacagtgata ttggtggtta taattat                                           27


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR1

<400>  39

Asn Ser Asp Ile Gly Gly Tyr Asn Tyr 
1               5                   


<210>  40
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR2

<400>  40
gtctcctggt accaacaaca cccaggcaaa gcccccaaac tcatgattta t                51


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR2

<400>  41

Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
1               5                   10                  15      


Tyr 
    


<210>  42
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR2

<400>  42
gatgtctat                                                                9


<210>  43
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR2

<400>  43

Asp Val Tyr 
1           


<210>  44
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR3

<400>  44
aagcggccct caggggtccc tgatcgcttc tctggctcca agtctggcaa cacggcctcc       60

ctgaccatct ctgggctcca ggctgaggat gaggctgatt actactgc                   108


<210>  45
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR3

<400>  45

Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
1               5                   10                  15      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR3

<400>  46
tgctcatatg caggcaccaa caatttgata                                        30


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CDR3

<400>  47

Cys Ser Tyr Ala Gly Thr Asn Asn Leu Ile 
1               5                   10  


<210>  48
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, JUNCTION

<400>  48
tgctgctcat atgcaggcac caacaatttg atattc                                 36


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, JUNCTION

<400>  49

Cys Cys Ser Tyr Ala Gly Thr Asn Asn Leu Ile Phe 
1               5                   10          


<210>  50
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3'V-REGION

<400>  50
tgctgctcat atgcaggcac caacaattt                                         29


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3'V-REGION

<400>  51

Cys Cys Ser Tyr Ala Gly Thr Asn Asn 
1               5                   


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, J-REGION

<400>  52
tattcggcgg agggaccaag ctgaccgtcc tag                                    33


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, J-REGION

<400>  53

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  54
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR4

<400>  54
ttcggcggag ggaccaagct gaccgtccta g                                      31


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, FR4

<400>  55

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  56
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4A6 Heavy Chain

<400>  56
caggtccaac tggtgcaatc tggggctgaa gtgaagaagc ctggggcctc aatgagagtc       60

tcctgcaagg cttctggtta cacctacacc gcctactata tacattggat gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccccc acattggctc cacaaattat      180

gcggagaagt ttcgcggcag ggtcaccttg accagagaca cgtccatcaa gacagcctac      240

atggatctcg acaggctgac gtctgacgac acggccatat attactgtgc gagagtccga      300

gccccccgga gtataagtgg aactctcaac tcttacggaa tggacgtctg gggccaaggg      360

accacggtcg ccgtctcttc a                                                381


<210>  57
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4A6 Heavy Chain

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Tyr Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro His Ile Gly Ser Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ile Lys Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Asp Arg Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Ala Pro Arg Ser Ile Ser Gly Thr Leu Asn Ser Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ala Val Ser Ser 
        115                 120                 125         


<210>  58
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4A6 Light Chain

<400>  58
gacatcgtga tgacccagtc tccttcgtcc ctgtctgcat ctgtgggaga cagggtcgtc       60

atcacttgcc gggcaagtct gagaattggc acctttttaa attggtatca gcagacacaa      120

gggagagccc ccaaactcct ggtgtcttct gcgtccactt tgcaaagtgg cgtcccatca      180

aggttcagtg gcagtggatc tgggacggat ttcactctca ccattaacag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccacgtggac attcggccaa      300

gggaccaagg tggaactcaa a                                                321


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4A6 Light Chain

<400>  59

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Val Ile Thr Cys Arg Ala Ser Leu Arg Ile Gly Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Thr Gln Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Ser Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  60
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4G1 Heavy Chain

<400>  60
gaggagcacc tggtggagtc tgggggagcc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgaag cctctggatt cacctttcgt agttattgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggaatg gctggccaac atcaaacaag atggaagtga ctattactat      180

gtcgactctg tgaagggccg attcaccatc tccagagaca acgccaagaa tacactatat      240

ctgcagatga acaacctgag agccgacgac acggccgttt atttttgtgc gagagatgcg      300

agatatcggg acactacctg gccgcaatac tatttttact acttcatgga cgtctggggc      360

aaggggacca cggtcaccgt ctcctca                                          387


<210>  61
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4G1 Heavy Chain

<400>  61

Glu Glu His Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Asp Tyr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ala Arg Tyr Arg Asp Thr Thr Trp Pro Gln Tyr Tyr Phe 
            100                 105                 110         


Tyr Tyr Phe Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  62
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4G1 Light Chain

<400>  62
gacatccagt tgacccagtc tccatcctcc ctgtctgcct ctataggcga cagagtcacc       60

gtcacttgcc gggccagtca gagcattagt aattatttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccaatt tgcatactgg ggtcccatcg      180

aggttcagtg gcagtgggtc tgggacacat tttactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaactg agttacaata acccgagaac tttcggccct      300

gggaccacag tggatatcag a                                                321


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, ALZ.4G1 Light Chain

<400>  63

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Ser Tyr Asn Asn Pro Arg 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Thr Val Asp Ile Arg 
            100                 105         


