                         SEQUENCE LISTING

<110>  National University of Singapore
 
<120>  CHIMERIC ANTIGEN RECEPTORS AND GENE EDITING OF CD2 FOR 
       IMMUNOTHERAPY OF T-CELL MALIGNANCIES

<130>  119419-5005-WO

<140>  Filed Herewith
<141>  2019-05-23

<150>  62/675,525
<151>  2018-05-23

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ser Ser 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
                165                 170                 175     


Val Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Thr 
        195                 200                 205             


Asp Lys Ala Ile Ser Thr Ile Asp Thr Ser Ser Asn Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Thr Leu Thr Ser Asp Ala Ser Ala Val Tyr Tyr Cys Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Asp Ser Ser Thr Asn Leu Ala Asp Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys Asp Glu 
        275                 280                 285             


Leu 
    


<210>  2
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ser Ser 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
                165                 170                 175     


Val Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Thr 
        195                 200                 205             


Asp Lys Ala Ile Ser Thr Ile Asp Thr Ser Ser Asn Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Thr Leu Thr Ser Asp Ala Ser Ala Val Tyr Tyr Cys Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Asp Ser Ser Thr Asn Leu Ala Asp Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Lys Tyr Lys 
                325                 330                 335     


Ser Arg Arg Ser Phe Ile Glu Glu Lys Lys Met Pro 
            340                 345             


<210>  3
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Ala Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Val 
            100                 105                 110         


Tyr Tyr Cys His Gln Tyr Leu Ser Ser His Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Arg Tyr Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly 
    210                 215                 220                 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Thr Glu Asp Leu Tyr Tyr Ala Met Glu Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys 
        275                 280                 285             


Asp Glu Leu 
    290     


<210>  4
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Ala Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Val 
            100                 105                 110         


Tyr Tyr Cys His Gln Tyr Leu Ser Ser His Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Arg Tyr Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly 
    210                 215                 220                 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Thr Glu Asp Leu Tyr Tyr Ala Met Glu Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Lys 
                325                 330                 335     


Tyr Lys Ser Arg Arg Ser Phe Ile Glu Glu Lys Lys Met Pro 
            340                 345                 350 


<210>  5
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Ala Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Val 
            100                 105                 110         


Tyr Tyr Cys His Gln Tyr Leu Ser Ser His Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
145                 150                 155                 160 


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Arg Tyr Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly 
    210                 215                 220                 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Thr Glu Asp Leu Tyr Tyr Ala Met Glu Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  6
<211>  892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  6
gaattcggct tccaccatgg ctctgcccgt gaccgccctg ctgctgcctc tggctctgct       60

gctgcacgct gcccgcccaa tcgtgatgac ccagagccca gccaccctgt ccgtgacacc      120

tggcgaccgg gtgtctctga gctgcagagc ctcccagtct atcagcgatt acctgcactg      180

gtatcagcag aagtcccacg agtctccccg gctgctgatc aagtacgcta gccagtctat      240

cagcggcatc cctagccggt tctccggatc tggaagcgga tccgacttta ccctgagcat      300

caactccgtg gagccagagg atgtgggcgt gtactattgc cagaatggcc actccttccc      360

cctgaccttt ggcgccggca caaagctgga gctgcggaga ggcggcggcg gctctggagg      420

aggaggaagc ggaggaggag gctcccaggt gcagctgcag cagccaggaa cagagctggt      480

gcggcccggc agctccgtga agctgtcctg taaggcctct ggctacacct tcacaagcta      540

ttgggtgaac tgggtgaagc agaggcctga ccagggcctg gagtggatcg gaaggatcga      600

cccatacgat tctgagacac actataacca gaagtttaca gacaaggcca tcagcaccat      660

cgatacatct agcaataccg cctatatgca gctgtccacc ctgacatctg atgccagcgc      720

cgtgtactat tgttctagga gccctcgcga ctcctctaca aatctggcag attggggaca      780

gggcaccctg gtgacagtga gctccggtgg tggcggcagt ggtggcggtg gctcaggcgg      840

tggtggctcc ggtggcggtg gctctgcaga aaaagatgag ttgtaactcg ag              892


<210>  7
<211>  1069
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  7
gaattcggct tccaccatgg ctctgcccgt gaccgccctg ctgctgcctc tggctctgct       60

gctgcacgct gcccgcccaa tcgtgatgac ccagagccca gccaccctgt ccgtgacacc      120

tggcgaccgg gtgtctctga gctgcagagc ctcccagtct atcagcgatt acctgcactg      180

gtatcagcag aagtcccacg agtctccccg gctgctgatc aagtacgcta gccagtctat      240

cagcggcatc cctagccggt tctccggatc tggaagcgga tccgacttta ccctgagcat      300

caactccgtg gagccagagg atgtgggcgt gtactattgc cagaatggcc actccttccc      360

cctgaccttt ggcgccggca caaagctgga gctgcggaga ggcggcggcg gctctggagg      420

aggaggaagc ggaggaggag gctcccaggt gcagctgcag cagccaggaa cagagctggt      480

gcggcccggc agctccgtga agctgtcctg taaggcctct ggctacacct tcacaagcta      540

ttgggtgaac tgggtgaagc agaggcctga ccagggcctg gagtggatcg gaaggatcga      600

cccatacgat tctgagacac actataacca gaagtttaca gacaaggcca tcagcaccat      660

cgatacatct agcaataccg cctatatgca gctgtccacc ctgacatctg atgccagcgc      720

cgtgtactat tgttctagga gccctcgcga ctcctctaca aatctggcag attggggaca      780

gggcaccctg gtgacagtga gctccaagcc aaccacaacc cctgcaccaa ggccacctac      840

accagcacct accatcgcaa gccagccact gtccctgagg ccagaggcat gtaggcctgc      900

agcaggaggc gccgtgcaca cacgcggcct ggactttgcc tgcgatatct acatctgggc      960

accactggca ggaacctgtg gcgtgctgct gctgagcctg gtgattaccc tgtataagta     1020

caagtccaga cgctcattca ttgaggaaaa gaaaatgcct taactcgag                 1069


<210>  8
<211>  898
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  8
gaattcggct tccaccatgg ctctgcccgt gaccgccctg ctgctgcctc tggctctgct       60

gctgcacgct gcccgcccaa acatcatgat gacccagtcc cccagctccc tggccgtgtc      120

tgccggagag aaggtgacca tgacatgcaa gtctagccag tccgtgctgt actcctctaa      180

ccagaagaat tacctggcct ggtatcagca gaagcccggc cagagcccta agctgctgat      240

ctattgggca agcacccggg agtccggagt gccagacaga ttcaccggaa gcggatccgg      300

aacagacttc accctgacaa tcagctccgt gcagcctgag gacctggccg tgtactattg      360

ccaccagtac ctgtctagcc acaccttcgg cggcggcaca aagctggaga tcaagagggg      420

aggaggagga tccggaggag gaggctctgg cggcggcggc agccagctgc agcagccagg      480

agcagagctg gtgaggcccg gctcctctgt gaagctgtct tgtaaggcca gcggctacac      540

cttcacaagg tattggatcc actgggtgaa gcagcgccct atccagggcc tggagtggat      600

cggcaacatc gacccatctg atagcgagac acactacaat cagaagttta aggacaaggc      660

caccctgaca gtggataaga gctccggcac cgcctatatg cagctgtcta gcctgacatc      720

cgaggactct gccgtgtact attgtgccac agaggatctg tactatgcca tggagtactg      780

gggccagggc acctccgtga cagtgtcctc tggtggtggc ggcagtggtg gcggtggctc      840

aggcggtggt ggctccggtg gcggtggctc tgcagaaaaa gatgagttgt aactcgag        898


<210>  9
<211>  1075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  9
gaattcggct tccaccatgg ctctgcccgt gaccgccctg ctgctgcctc tggctctgct       60

gctgcacgct gcccgcccaa acatcatgat gacccagtcc cccagctccc tggccgtgtc      120

tgccggagag aaggtgacca tgacatgcaa gtctagccag tccgtgctgt actcctctaa      180

ccagaagaat tacctggcct ggtatcagca gaagcccggc cagagcccta agctgctgat      240

ctattgggca agcacccggg agtccggagt gccagacaga ttcaccggaa gcggatccgg      300

aacagacttc accctgacaa tcagctccgt gcagcctgag gacctggccg tgtactattg      360

ccaccagtac ctgtctagcc acaccttcgg cggcggcaca aagctggaga tcaagagggg      420

aggaggagga tccggaggag gaggctctgg cggcggcggc agccagctgc agcagccagg      480

agcagagctg gtgaggcccg gctcctctgt gaagctgtct tgtaaggcca gcggctacac      540

cttcacaagg tattggatcc actgggtgaa gcagcgccct atccagggcc tggagtggat      600

cggcaacatc gacccatctg atagcgagac acactacaat cagaagttta aggacaaggc      660

caccctgaca gtggataaga gctccggcac cgcctatatg cagctgtcta gcctgacatc      720

cgaggactct gccgtgtact attgtgccac agaggatctg tactatgcca tggagtactg      780

gggccagggc acctccgtga cagtgtcctc taagccaacc acaacccctg caccaaggcc      840

acctacacca gcacctacca tcgcaagcca gccactgtcc ctgaggccag aggcatgtag      900

gcctgcagca ggaggcgccg tgcacacacg cggcctggac tttgcctgcg atatctacat      960

ctgggcacca ctggcaggaa cctgtggcgt gctgctgctg agcctggtga ttaccctgta     1020

taagtacaag tccagacgct cattcattga ggaaaagaaa atgccttaac tcgag          1075


<210>  10
<211>  1549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  10
gaattcggct tccaccatgg ctctgcccgt gaccgccctg ctgctgcctc tggctctgct       60

gctgcacgct gcccgcccaa acatcatgat gacccagtcc cccagctccc tggccgtgtc      120

tgccggagag aaggtgacca tgacatgcaa gtctagccag tccgtgctgt actcctctaa      180

ccagaagaat tacctggcct ggtatcagca gaagcccggc cagagcccta agctgctgat      240

ctattgggca agcacccggg agtccggagt gccagacaga ttcaccggaa gcggatccgg      300

aacagacttc accctgacaa tcagctccgt gcagcctgag gacctggccg tgtactattg      360

ccaccagtac ctgtctagcc acaccttcgg cggcggcaca aagctggaga tcaagagggg      420

aggaggagga tccggaggag gaggctctgg cggcggcggc agccagctgc agcagccagg      480

agcagagctg gtgaggcccg gctcctctgt gaagctgtct tgtaaggcca gcggctacac      540

cttcacaagg tattggatcc actgggtgaa gcagcgccct atccagggcc tggagtggat      600

cggcaacatc gacccatctg atagcgagac acactacaat cagaagttta aggacaaggc      660

caccctgaca gtggataaga gctccggcac cgcctatatg cagctgtcta gcctgacatc      720

cgaggactct gccgtgtact attgtgccac agaggatctg tactatgcca tggagtactg      780

gggccagggc acctccgtga cagtgtcctc taccactaca cctgcaccaa ggcctcccac      840

acccgctccc actatcgctt cccagccact gtccctgagg cccgaggcct gcaggccagc      900

agctggcgga gccgtgcata ctagggggct ggacttcgct tgcgacatct acatctgggc      960

cccactggca gggacatgcg gagtcctgct gctgtccctg gtcatcacac tgtactgcaa     1020

gcgggggcgc aaaaaactgc tgtatatctt taagcagcct ttcatgagac cagtgcagac     1080

aacccaggag gaagatgggt gctcatgccg gtttcccgag gaggaggaag gcggctgcga     1140

gctgagggtg aagttttccc gctcagcaga tgctcctgcc taccagcagg gccagaacca     1200

gctgtataat gagctgaacc tgggcagacg cgaagagtat gatgtgctgg acaaaaggcg     1260

gggaagagac cccgaaatgg gagggaagcc aaggcggaaa aacccccagg agggcctgta     1320

caatgagctg cagaaggaca aaatggcaga ggcttacagt gagattggga tgaagggaga     1380

gagacggagg ggaaaagggc acgatggcct gtaccagggg ctgagcacag caaccaaaga     1440

tacttatgac gcactgcaca tgcaggcact gccacccaga tgacagccag gggatttcac     1500

cactcaaagg ccagacctgc agacgcccag attatgagac acactcgag                 1549


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Ala Glu Lys Asp Glu Leu 
            20                  25      


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Leu Tyr Lys Tyr Lys Ser Arg Arg Ser Phe Ile Glu Glu Lys Lys Met 
1               5                   10                  15      


Pro 
    


<210>  15
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  15

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Ile 
    50                  55                  60                  


Thr Leu Tyr 
65          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  17

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Asp Lys Ala Ile Ser Thr Ile Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Thr Leu Thr Ser Asp Ala Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Pro Arg Asp Ser Ser Thr Asn Leu Ala Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  19

Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp 
1               5                   10                  15      


Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys 
        35                  40                  45              


Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg 
            100                 105         


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Trp Ile 
            20                  25                  30          


His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile Gly Asn 
        35                  40                  45              


Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp 
    50                  55                  60                  


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly Thr Ala Tyr Met Gln 
65                  70                  75                  80  


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Thr 
                85                  90                  95      


Glu Asp Leu Tyr Tyr Ala Met Glu Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  22
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp 
1               5                   10                  15      


Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys 
        35                  40                  45              


Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Pro Gly Thr Glu Leu Val Arg Pro Gly Ser Ser Val Lys Leu Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Val Asn Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
                165                 170                 175     


Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Thr Asp Lys Ala Ile Ser 
            180                 185                 190         


Thr Ile Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Thr Leu 
        195                 200                 205             


Thr Ser Asp Ala Ser Ala Val Tyr Tyr Cys Ser Arg Ser Pro Arg Asp 
    210                 215                 220                 


Ser Ser Thr Asn Leu Ala Asp Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  23
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  23

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Trp Ile 
145                 150                 155                 160 


His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile Gly Asn 
                165                 170                 175     


Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp 
            180                 185                 190         


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Gly Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Thr 
    210                 215                 220                 


Glu Asp Leu Tyr Tyr Ala Met Glu Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Lys Asp Glu Leu 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Lys Lys Asp Glu 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Lys Lys Xaa Xaa 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  27

Lys Lys Met Pro 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  28

Tyr Gln Arg Leu 
1               


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  29

Ala Glu Lys Asp Glu Leu 
1               5       


<210>  30
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  30

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Ala Glu Lys Asp Glu Leu 
            20                  25      


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  31

Leu Tyr Lys Tyr Lys Ser Arg Arg Ser Phe Ile Glu Glu Lys Lys Met 
1               5                   10                  15      


Pro 
    


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  wherein n is 1-10

<400>  32

Gly Gly Gly Ser 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  wherein n is 1-10

<400>  33

Gly Gly Ser Gly 
1               


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(5)
<223>  wherein n is 1-10

<400>  34

Gly Gly Ser Gly Gly 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(5)
<223>  wherein n is 1-10

<400>  35

Gly Gly Gly Gly Ser 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  36

Gly Gly Gly Gly Ser 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  37

Gly Gly Gly Gly Ser 
1               5   


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  40

Tyr Gly Arg Leu 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  41

Tyr Gln Arg Leu 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  42

Tyr Lys Gly Leu 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Tyr Xaa Xaa Leu 
1               


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  44
caaagagatt acgaatgcct                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  45
cttgtagata tcctgatcat                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  46
cacgcacctg gacagctgac                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  47
ggttgtgttg atacaagtcc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  48
agcttggaac agactcacgg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  49
aatgggcgga ggagagtagt                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  50
cctttccggg actttcgctt t                                                 21


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  51
gcagaatcca ggtggcaaca                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  52
agggaactgt gggatgactg                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  53
gaacacctga gcctttgagc                                                   20


