                         SEQUENCE LISTING

<110>  Shen, Jie
       Kelleher, Raymond  J. III
 
<120>  GENE THERAPY FOR ALZHEIMER'S DISEASE

<130>  29618-0229WO1

<140>  PCT/US2019/033616
<141>  2019-05-22

<150>  62/675,003
<151>  2018-05-22

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  6107
<212>  DNA
<213>  Homo sapiens

<400>  1
aaatgacgac aacggtgagg gttctcgggc ggggcctggg acaggcagct ccggggtccg       60

cggtttcaca tcggaaacaa aacagcggct ggtctggaag gaacctgagc tacgagccgc      120

ggcggcagcg gggcggcggg gaagcgtata cctaatctgg gagcctgcaa gtgacaacag      180

cctttgcggt ccttagacag cttggcctgg aggagaacac atgaaagaaa gaacctcaag      240

aggctttgtt ttctgtgaaa cagtatttct atacagttgc tccaatgaca gagttacctg      300

caccgttgtc ctacttccag aatgcacaga tgtctgagga caaccacctg agcaatactg      360

tacgtagcca gaatgacaat agagaacggc aggagcacaa cgacagacgg agccttggcc      420

accctgagcc attatctaat ggacgacccc agggtaactc ccggcaggtg gtggagcaag      480

atgaggaaga agatgaggag ctgacattga aatatggcgc caagcatgtg atcatgctct      540

ttgtccctgt gactctctgc atggtggtgg tcgtggctac cattaagtca gtcagctttt      600

atacccggaa ggatgggcag ctaatctata ccccattcac agaagatacc gagactgtgg      660

gccagagagc cctgcactca attctgaatg ctgccatcat gatcagtgtc attgttgtca      720

tgactatcct cctggtggtt ctgtataaat acaggtgcta taaggtcatc catgcctggc      780

ttattatatc atctctattg ttgctgttct ttttttcatt catttacttg ggggaagtgt      840

ttaaaaccta taacgttgct gtggactaca ttactgttgc actcctgatc tggaattttg      900

gtgtggtggg aatgatttcc attcactgga aaggtccact tcgactccag caggcatatc      960

tcattatgat tagtgccctc atggccctgg tgtttatcaa gtacctccct gaatggactg     1020

cgtggctcat cttggctgtg atttcagtat atgatttagt ggctgttttg tgtccgaaag     1080

gtccacttcg tatgctggtt gaaacagctc aggagagaaa tgaaacgctt tttccagctc     1140

tcatttactc ctcaacaatg gtgtggttgg tgaatatggc agaaggagac ccggaagctc     1200

aaaggagagt atccaaaaat tccaagtata atgcagaaag cacagaaagg gagtcacaag     1260

acactgttgc agagaatgat gatggcgggt tcagtgagga atgggaagcc cagagggaca     1320

gtcatctagg gcctcatcgc tctacacctg agtcacgagc tgctgtccag gaactttcca     1380

gcagtatcct cgctggtgaa gacccagagg aaaggggagt aaaacttgga ttgggagatt     1440

tcattttcta cagtgttctg gttggtaaag cctcagcaac agccagtgga gactggaaca     1500

caaccatagc ctgtttcgta gccatattaa ttggtttgtg ccttacatta ttactccttg     1560

ccattttcaa gaaagcattg ccagctcttc caatctccat cacctttggg cttgttttct     1620

actttgccac agattatctt gtacagcctt ttatggacca attagcattc catcaatttt     1680

atatctagca tatttgcggt tagaatccca tggatgtttc ttctttgact ataacaaaat     1740

ctggggagga caaaggtgat tttcctgtgt ccacatctaa caaagtcaag attcccggct     1800

ggacttttgc agcttccttc caagtcttcc tgaccacctt gcactattgg actttggaag     1860

gaggtgccta tagaaaacga ttttgaacat acttcatcgc agtggactgt gtccctcggt     1920

gcagaaacta ccagatttga gggacgaggt caaggagata tgataggccc ggaagttgct     1980

gtgccccatc agcagcttga cgcgtggtca caggacgatt tcactgacac tgcgaactct     2040

caggactacc gttaccaaga ggttaggtga agtggtttaa accaaacgga actcttcatc     2100

ttaaactaca cgttgaaaat caacccaata attctgtatt aactgaattc tgaacttttc     2160

aggaggtact gtgaggaaga gcaggcacca gcagcagaat ggggaatgga gaggtgggca     2220

ggggttccag cttccctttg attttttgct gcagactcat cctttttaaa tgagacttgt     2280

tttcccctct ctttgagtca agtcaaatat gtagattgcc tttggcaatt cttcttctca     2340

agcactgaca ctcattaccg tctgtgattg ccatttcttc ccaaggccag tctgaacctg     2400

aggttgcttt atcctaaaag ttttaacctc aggttccaaa ttcagtaaat tttggaaaca     2460

gtacagctat ttctcatcaa ttctctatca tgttgaagtc aaatttggat tttccaccaa     2520

attctgaatt tgtagacata cttgtacgct cacttgcccc agatgcctcc tctgtcctca     2580

ttcttctctc ccacacaagc agtctttttc tacagccagt aaggcagctc tgtcgtggta     2640

gcagatggtc ccattattct agggtcttac tctttgtatg atgaaaagaa tgtgttatga     2700

atcggtgctg tcagccctgc tgtcagacct tcttccacag caaatgagat gtatgcccaa     2760

agacggtaga attaaagaag agtaaaatgg ctgttgaagc actttctgtc ctggtatttt     2820

gtttttgctt ttgccacaca gtagctcaga atttgaacaa atagccaaaa gctggtggtt     2880

gatgaattat gaactagttg tatcaacaca aagcaagagt tggggaaagc catatttaac     2940

ttggtgagct gtgggagaac ctggtggcag aaggagaacc aactgccaag gggaaagaga     3000

aggggcctcc agcagcgaag gggatacagt gagctaatga tgtcaaggag gagtttcagg     3060

ttattctcgt cagctccaca aatgggtgct ttgtggtctc tgcccgcgtt acctttcctc     3120

tcaatgtacc tttgtgtgaa ctgggcagtg gaggtgcctg ctgcagttac catggagttc     3180

aggctctggg cagctcagtc aggcaaaaca cacaaacagc catcagcctg tgtgggctca     3240

gggcacctct ggacaaaggc ttgtggggca taaccttctt taccacagag agcccttagc     3300

tatgctgatc agaccgtaag cgtttatgag aaacttagtt tcctcctgtg gctgaggagg     3360

ggccagcttt ttcttctttt gcctgctgtt ttctctccca atctatgata tgatatgacc     3420

tggtttgggg ctgtctttgg tgtttagaat atttgttttc tgtcccagga tatttcttat     3480

aagaacctaa cttcaagagt agtgtgcgag tactgatctg aatttaaatt aaaattggct     3540

tatattaggc agtcacagac aggaaaaata agagctatgc aaagaaaggg ggatttaaag     3600

tagtaggttc tatcatctca attcattttt ttccatgaaa tcccttcttc caagattcat     3660

tccctctctc agacatgtgc tagcatgggt attatcattg agaaagcaca gctacagcaa     3720

agccacctga atagcaattt gtgattggaa gcattcttga gggatcccta atctagagta     3780

atttatttgt gtaaggatcc caaatgtgtt gcacctttca tgatacattt cttctctgaa     3840

gagggtacgt ggggtgtgtg tatttaaatc catcctatgt attactgatt gtcctgtgta     3900

gaaagatggc aattattctg tctctttctc caagtttgag ccacatctca gccacattgt     3960

tagacagtgt acagagaacc tatctttcct tttttttttt ttaaaggaca ggattttgct     4020

gtgttgccca ggctagactt gaactcctgg gctcaagtaa tccacctcag cctgagtagc     4080

tgagactaca gcccatctta tttctttaaa tcattcatct caggcagaga acttttccct     4140

caaacattct ttttagaatt agttcagtca ttcctaaaac atccaaatgc tagtcttcca     4200

ccatgaaaaa tagattgtca ctggaaagaa cagtagcaat ttccataagg atgtgccttc     4260

actcacacgg gacaggcggt ggttatagag tcgggcaaaa ccagcagtag agtatgacca     4320

gccaagccaa tctgcttaat aaaaagatgg aagacagtaa ggaaggaaag tagccactaa     4380

gagtctgagt ctgactgggc tacagaataa agggtattta tggacagaat gtcattacat     4440

gcctatggga ataccaatca tatttggaag atttgcagat tttttttcag agaggaaaga     4500

ctcaccttcc tgtttttggt tctcagtagg ttcgtgtgtg ttcctagaat cacagctctg     4560

actccaaatg actcaatttc tcaattagaa aaagtagaag ctttctaagc aacttggaag     4620

aaaacagtca taagtaagca atttgttgat tttactacag aagcaacaac tgaagaggca     4680

gtgtttttac tttcagactc cgggattccc attctgtagt ctctctgctt ttaaaaaccc     4740

tccttttgca atagatgccc aaacagatga tgtttattac ttgttattta cgtggcctca     4800

gacagtgtat gtattctcga tataacttgt agagtgtgaa atataagttt aactaccaaa     4860

taaggtctcc cagggttaga tgactgcggg aagcctttga tcccaacccc caaggctttg     4920

tatatttgat catttgtgat ctaaccctgg aagaaaaaga gctcagaaac cactatgaaa     4980

aaatttgttc agtgttttct gtgttcccgt aggttctgga gtctgaggat gcaaagatga     5040

ataagataaa ttctcagaat gtagttataa tctcttgttt tctggtatat gccatctttc     5100

tttaacttct ctaaaatatt gggtatttgt caaataacca cttttaacag ttaccattac     5160

tgagggctta tacattggtg ttataaaagt gacttgattc agaaatcaat ccattcagta     5220

aagtactcct tctctaaatt tgctgttatg tctataagga acagtttgac ctgcccttct     5280

cctcacctcc tcacctgcct tccaacattg aatttggaag gagacgtgaa aattggacat     5340

ttggttttgc ccttgggctg gaaactatca tataatcata agtttgagcc tagaagtgat     5400

ccttgtgatc ttctcacctc tttaaattcc cacaacacaa gagattaaaa acagaggttt     5460

cagctcttca tagtgcgttg tgaaatggct ggccagagtg taccaacaaa gctgtcatcg     5520

ggctcacagc tcagagacat ctgcatgtga tcatctgcat agtcctctcc tctaacggga     5580

aacacctcag atttgcatat aaaaaagcac cctggtgctg aaatgaaccc ctttcttgaa     5640

catcaaagct gtctcccaca gccttgggca gcagggtgcc tcttagtgga tgtgctgggt     5700

ccaccctgag ccctgacatg tggtggcagc attgccagtt ggtctgtgtg tctgtgtagc     5760

agggacgatt tcccagaaag caattttcct tttgaaatac gtaattgttg agactaggca     5820

gtttcaaagt cagctgcata tagtagcaag tacaggactg tcttgttttt ggtgtccttg     5880

gaggtgctgg ggtgagggtt tcagtgggat catttactct cacatgttgt ctgccttctg     5940

cttctgtgga cactgctttg tacttaattc agacagactg tgaatacacc ttttttataa     6000

atacctttca aattcttggt aagatataat tttgatagct gattgcagat tttctgtatt     6060

tgtcagatta ataaagactg catgaatcca aaaaaaaaaa aaaaaaa                   6107


<210>  2
<211>  6095
<212>  DNA
<213>  Homo sapiens

<400>  2
aaatgacgac aacggtgagg gttctcgggc ggggcctggg acaggcagct ccggggtccg       60

cggtttcaca tcggaaacaa aacagcggct ggtctggaag gaacctgagc tacgagccgc      120

ggcggcagcg gggcggcggg gaagcgtata cctaatctgg gagcctgcaa gtgacaacag      180

cctttgcggt ccttagacag cttggcctgg aggagaacac atgaaagaaa gaacctcaag      240

aggctttgtt ttctgtgaaa cagtatttct atacagttgc tccaatgaca gagttacctg      300

caccgttgtc ctacttccag aatgcacaga tgtctgagga caaccacctg agcaatacta      360

atgacaatag agaacggcag gagcacaacg acagacggag ccttggccac cctgagccat      420

tatctaatgg acgaccccag ggtaactccc ggcaggtggt ggagcaagat gaggaagaag      480

atgaggagct gacattgaaa tatggcgcca agcatgtgat catgctcttt gtccctgtga      540

ctctctgcat ggtggtggtc gtggctacca ttaagtcagt cagcttttat acccggaagg      600

atgggcagct aatctatacc ccattcacag aagataccga gactgtgggc cagagagccc      660

tgcactcaat tctgaatgct gccatcatga tcagtgtcat tgttgtcatg actatcctcc      720

tggtggttct gtataaatac aggtgctata aggtcatcca tgcctggctt attatatcat      780

ctctattgtt gctgttcttt ttttcattca tttacttggg ggaagtgttt aaaacctata      840

acgttgctgt ggactacatt actgttgcac tcctgatctg gaattttggt gtggtgggaa      900

tgatttccat tcactggaaa ggtccacttc gactccagca ggcatatctc attatgatta      960

gtgccctcat ggccctggtg tttatcaagt acctccctga atggactgcg tggctcatct     1020

tggctgtgat ttcagtatat gatttagtgg ctgttttgtg tccgaaaggt ccacttcgta     1080

tgctggttga aacagctcag gagagaaatg aaacgctttt tccagctctc atttactcct     1140

caacaatggt gtggttggtg aatatggcag aaggagaccc ggaagctcaa aggagagtat     1200

ccaaaaattc caagtataat gcagaaagca cagaaaggga gtcacaagac actgttgcag     1260

agaatgatga tggcgggttc agtgaggaat gggaagccca gagggacagt catctagggc     1320

ctcatcgctc tacacctgag tcacgagctg ctgtccagga actttccagc agtatcctcg     1380

ctggtgaaga cccagaggaa aggggagtaa aacttggatt gggagatttc attttctaca     1440

gtgttctggt tggtaaagcc tcagcaacag ccagtggaga ctggaacaca accatagcct     1500

gtttcgtagc catattaatt ggtttgtgcc ttacattatt actccttgcc attttcaaga     1560

aagcattgcc agctcttcca atctccatca cctttgggct tgttttctac tttgccacag     1620

attatcttgt acagcctttt atggaccaat tagcattcca tcaattttat atctagcata     1680

tttgcggtta gaatcccatg gatgtttctt ctttgactat aacaaaatct ggggaggaca     1740

aaggtgattt tcctgtgtcc acatctaaca aagtcaagat tcccggctgg acttttgcag     1800

cttccttcca agtcttcctg accaccttgc actattggac tttggaagga ggtgcctata     1860

gaaaacgatt ttgaacatac ttcatcgcag tggactgtgt ccctcggtgc agaaactacc     1920

agatttgagg gacgaggtca aggagatatg ataggcccgg aagttgctgt gccccatcag     1980

cagcttgacg cgtggtcaca ggacgatttc actgacactg cgaactctca ggactaccgt     2040

taccaagagg ttaggtgaag tggtttaaac caaacggaac tcttcatctt aaactacacg     2100

ttgaaaatca acccaataat tctgtattaa ctgaattctg aacttttcag gaggtactgt     2160

gaggaagagc aggcaccagc agcagaatgg ggaatggaga ggtgggcagg ggttccagct     2220

tccctttgat tttttgctgc agactcatcc tttttaaatg agacttgttt tcccctctct     2280

ttgagtcaag tcaaatatgt agattgcctt tggcaattct tcttctcaag cactgacact     2340

cattaccgtc tgtgattgcc atttcttccc aaggccagtc tgaacctgag gttgctttat     2400

cctaaaagtt ttaacctcag gttccaaatt cagtaaattt tggaaacagt acagctattt     2460

ctcatcaatt ctctatcatg ttgaagtcaa atttggattt tccaccaaat tctgaatttg     2520

tagacatact tgtacgctca cttgccccag atgcctcctc tgtcctcatt cttctctccc     2580

acacaagcag tctttttcta cagccagtaa ggcagctctg tcgtggtagc agatggtccc     2640

attattctag ggtcttactc tttgtatgat gaaaagaatg tgttatgaat cggtgctgtc     2700

agccctgctg tcagaccttc ttccacagca aatgagatgt atgcccaaag acggtagaat     2760

taaagaagag taaaatggct gttgaagcac tttctgtcct ggtattttgt ttttgctttt     2820

gccacacagt agctcagaat ttgaacaaat agccaaaagc tggtggttga tgaattatga     2880

actagttgta tcaacacaaa gcaagagttg gggaaagcca tatttaactt ggtgagctgt     2940

gggagaacct ggtggcagaa ggagaaccaa ctgccaaggg gaaagagaag gggcctccag     3000

cagcgaaggg gatacagtga gctaatgatg tcaaggagga gtttcaggtt attctcgtca     3060

gctccacaaa tgggtgcttt gtggtctctg cccgcgttac ctttcctctc aatgtacctt     3120

tgtgtgaact gggcagtgga ggtgcctgct gcagttacca tggagttcag gctctgggca     3180

gctcagtcag gcaaaacaca caaacagcca tcagcctgtg tgggctcagg gcacctctgg     3240

acaaaggctt gtggggcata accttcttta ccacagagag cccttagcta tgctgatcag     3300

accgtaagcg tttatgagaa acttagtttc ctcctgtggc tgaggagggg ccagcttttt     3360

cttcttttgc ctgctgtttt ctctcccaat ctatgatatg atatgacctg gtttggggct     3420

gtctttggtg tttagaatat ttgttttctg tcccaggata tttcttataa gaacctaact     3480

tcaagagtag tgtgcgagta ctgatctgaa tttaaattaa aattggctta tattaggcag     3540

tcacagacag gaaaaataag agctatgcaa agaaaggggg atttaaagta gtaggttcta     3600

tcatctcaat tcattttttt ccatgaaatc ccttcttcca agattcattc cctctctcag     3660

acatgtgcta gcatgggtat tatcattgag aaagcacagc tacagcaaag ccacctgaat     3720

agcaatttgt gattggaagc attcttgagg gatccctaat ctagagtaat ttatttgtgt     3780

aaggatccca aatgtgttgc acctttcatg atacatttct tctctgaaga gggtacgtgg     3840

ggtgtgtgta tttaaatcca tcctatgtat tactgattgt cctgtgtaga aagatggcaa     3900

ttattctgtc tctttctcca agtttgagcc acatctcagc cacattgtta gacagtgtac     3960

agagaaccta tctttccttt tttttttttt aaaggacagg attttgctgt gttgcccagg     4020

ctagacttga actcctgggc tcaagtaatc cacctcagcc tgagtagctg agactacagc     4080

ccatcttatt tctttaaatc attcatctca ggcagagaac ttttccctca aacattcttt     4140

ttagaattag ttcagtcatt cctaaaacat ccaaatgcta gtcttccacc atgaaaaata     4200

gattgtcact ggaaagaaca gtagcaattt ccataaggat gtgccttcac tcacacggga     4260

caggcggtgg ttatagagtc gggcaaaacc agcagtagag tatgaccagc caagccaatc     4320

tgcttaataa aaagatggaa gacagtaagg aaggaaagta gccactaaga gtctgagtct     4380

gactgggcta cagaataaag ggtatttatg gacagaatgt cattacatgc ctatgggaat     4440

accaatcata tttggaagat ttgcagattt tttttcagag aggaaagact caccttcctg     4500

tttttggttc tcagtaggtt cgtgtgtgtt cctagaatca cagctctgac tccaaatgac     4560

tcaatttctc aattagaaaa agtagaagct ttctaagcaa cttggaagaa aacagtcata     4620

agtaagcaat ttgttgattt tactacagaa gcaacaactg aagaggcagt gtttttactt     4680

tcagactccg ggattcccat tctgtagtct ctctgctttt aaaaaccctc cttttgcaat     4740

agatgcccaa acagatgatg tttattactt gttatttacg tggcctcaga cagtgtatgt     4800

attctcgata taacttgtag agtgtgaaat ataagtttaa ctaccaaata aggtctccca     4860

gggttagatg actgcgggaa gcctttgatc ccaaccccca aggctttgta tatttgatca     4920

tttgtgatct aaccctggaa gaaaaagagc tcagaaacca ctatgaaaaa atttgttcag     4980

tgttttctgt gttcccgtag gttctggagt ctgaggatgc aaagatgaat aagataaatt     5040

ctcagaatgt agttataatc tcttgttttc tggtatatgc catctttctt taacttctct     5100

aaaatattgg gtatttgtca aataaccact tttaacagtt accattactg agggcttata     5160

cattggtgtt ataaaagtga cttgattcag aaatcaatcc attcagtaaa gtactccttc     5220

tctaaatttg ctgttatgtc tataaggaac agtttgacct gcccttctcc tcacctcctc     5280

acctgccttc caacattgaa tttggaagga gacgtgaaaa ttggacattt ggttttgccc     5340

ttgggctgga aactatcata taatcataag tttgagccta gaagtgatcc ttgtgatctt     5400

ctcacctctt taaattccca caacacaaga gattaaaaac agaggtttca gctcttcata     5460

gtgcgttgtg aaatggctgg ccagagtgta ccaacaaagc tgtcatcggg ctcacagctc     5520

agagacatct gcatgtgatc atctgcatag tcctctcctc taacgggaaa cacctcagat     5580

ttgcatataa aaaagcaccc tggtgctgaa atgaacccct ttcttgaaca tcaaagctgt     5640

ctcccacagc cttgggcagc agggtgcctc ttagtggatg tgctgggtcc accctgagcc     5700

ctgacatgtg gtggcagcat tgccagttgg tctgtgtgtc tgtgtagcag ggacgatttc     5760

ccagaaagca attttccttt tgaaatacgt aattgttgag actaggcagt ttcaaagtca     5820

gctgcatata gtagcaagta caggactgtc ttgtttttgg tgtccttgga ggtgctgggg     5880

tgagggtttc agtgggatca tttactctca catgttgtct gccttctgct tctgtggaca     5940

ctgctttgta cttaattcag acagactgtg aatacacctt ttttataaat acctttcaaa     6000

ttcttggtaa gatataattt tgatagctga ttgcagattt tctgtatttg tcagattaat     6060

aaagactgca tgaatccaaa aaaaaaaaaa aaaaa                                6095


<210>  3
<211>  2302
<212>  DNA
<213>  Homo sapiens

<400>  3
ggggcctggg ccggcgccgg gtccggccgg gcgctcagcc agctgcgtaa actccgctgg       60

agcgcggcgg cagagcaggc atttccagca gtgaggagac agccagaagc aagcttttgg      120

agctgaagga acctgagaca gaagctagtc ccccctctga attttactga tgaagaaact      180

gaggccacag agctaaagtg acttttccca aggtcgccca gcgaggacgt gggacttctc      240

agacgtcagg agagtgatgt gagggagctg tgtgaccata gaaagtgacg tgttaaaaac      300

cagcgctgcc ctctttgaaa gccagggagc atcattcatt tagcctgctg agaagaagaa      360

accaagtgtc cgggattcag acctctctgc ggccccaagt gttcgtggtg cttccagagg      420

cagggctatg ctcacattca tggcctctga cagcgaggaa gaagtgtgtg atgagcggac      480

gtccctaatg tcggctgaga gccccacgcc gcgctcctgc caggagggca ggcagggccc      540

agaggatgga gagaacactg cccagtggag aagccaggag aacgaggagg acggtgagga      600

ggaccctgac cgctatgtct gtagtggggt tcccgggcgg ccgccaggcc tggaggaaga      660

gctgaccctc aaatacggag cgaagcacgt gatcatgctg tttgtgcctg tcactctgtg      720

catgatcgtg gtggtagcca ccatcaagtc tgtgcgcttc tacacagaga agaatggaca      780

gctcatctac acgccattca ctgaggacac accctcggtg ggccagcgcc tcctcaactc      840

cgtgctgaac accctcatca tgatcagcgt catcgtggtt atgaccatct tcttggtggt      900

gctctacaag taccgctgct acaagttcat ccatggctgg ttgatcatgt cttcactgat      960

gctgctgttc ctcttcacct atatctacct tggggaagtg ctcaagacct acaatgtggc     1020

catggactac cccaccctct tgctgactgt ctggaacttc ggggcagtgg gcatggtgtg     1080

catccactgg aagggccctc tggtgctgca gcaggcctac ctcatcatga tcagtgcgct     1140

catggcccta gtgttcatca agtacctccc agagtggtcc gcgtgggtca tcctgggcgc     1200

catctctgtg tatgatctcg tggctgtgct gtgtcccaaa gggcctctga gaatgctggt     1260

agaaactgcc caggagagaa atgagcccat attccctgcc ctgatatact catctgccat     1320

ggtgtggacg gttggcatgg cgaagctgga cccctcctct cagggtgccc tccagctccc     1380

ctacgacccg gagatggaag aagactccta tgacagtttt ggggagcctt cataccccga     1440

agtctttgag cctcccttga ctggctaccc aggggaggag ctggaggaag aggaggaaag     1500

gggcgtgaag cttggcctcg gggacttcat cttctacagt gtgctggtgg gcaaggcggc     1560

tgccacgggc agcggggact ggaataccac gctggcctgc ttcgtggcca tcctcattgg     1620

cttgtgtctg accctcctgc tgcttgctgt gttcaagaag gcgctgcccg ccctccccat     1680

ctccatcacg ttcgggctca tcttttactt ctccacggac aacctggtgc ggccgttcat     1740

ggacaccctg gcctcccatc agctctacat ctgagggaca tggtgtgcca caggctgcaa     1800

gctgcaggga attttcattg gatgcagttg tatagtttta cactctagtg ccatatattt     1860

ttaagacttt tctttcctta aaaaataaag tacgtgttta cttggtgagg aggaggcaga     1920

accagctctt tggtgccagc tgtttcatca ccagactttg gctcccgctt tggggagcgc     1980

ctcgcttcac ggacaggaag cacagcaggt ttatccagat gaactgagaa ggtcagatta     2040

gggcggggag aagagcatcc ggcatgaggg ctgagatgcg caaagagtgt gctcgggagt     2100

ggcccctggc acctgggtgc tctggctgga gaggaaaagc cagttcccta cgaggagtgt     2160

tcccaatgct ttgtccatga tgtccttgtt attttattgc ctttagaaac tgagtcctgt     2220

tcttgttacg gcagtcacac tgctgggaag tggcttaata gtaatatcaa taaatagatg     2280

agtcctgtta gaatcttgaa aa                                              2302


<210>  4
<211>  2299
<212>  DNA
<213>  Homo sapiens

<400>  4
ggggcctggg ccggcgccgg gtccggccgg gcgctcagcc agctgcgtaa actccgctgg       60

agcgcggcgg cagagcaggc atttccagca gtgaggagac agccagaagc aagcttttgg      120

agctgaagga acctgagaca gaagctagtc ccccctctga attttactga tgaagaaact      180

gaggccacag agctaaagtg acttttccca aggtcgccca gcgaggacgt gggacttctc      240

agacgtcagg agagtgatgt gagggagctg tgtgaccata gaaagtgacg tgttaaaaac      300

cagcgctgcc ctctttgaaa gccagggagc atcattcatt tagcctgctg agaagaagaa      360

accaagtgtc cgggattcag acctctctgc ggccccaagt gttcgtggtg cttccagagg      420

cagggctatg ctcacattca tggcctctga cagcgaggaa gaagtgtgtg atgagcggac      480

gtccctaatg tcggctgaga gccccacgcc gcgctcctgc caggagggca ggcagggccc      540

agaggatgga gagaacactg cccagtggag aagccaggag aacgaggagg acggtgagga      600

ggaccctgac cgctatgtct gtagtggggt tcccgggcgg ccgccaggcc tggaggaaga      660

gctgaccctc aaatacggag cgaagcacgt gatcatgctg tttgtgcctg tcactctgtg      720

catgatcgtg gtggtagcca ccatcaagtc tgtgcgcttc tacacagaga agaatggaca      780

gctcatctac acgccattca ctgaggacac accctcggtg ggccagcgcc tcctcaactc      840

cgtgctgaac accctcatca tgatcagcgt catcgtggtt atgaccatct tcttggtggt      900

gctctacaag taccgctgct acaagttcat ccatggctgg ttgatcatgt cttcactgat      960

gctgctgttc ctcttcacct atatctacct tggggaagtg ctcaagacct acaatgtggc     1020

catggactac cccaccctct tgctgactgt ctggaacttc ggggcagtgg gcatggtgtg     1080

catccactgg aagggccctc tggtgctgca gcaggcctac ctcatcatga tcagtgcgct     1140

catggcccta gtgttcatca agtacctccc agagtggtcc gcgtgggtca tcctgggcgc     1200

catctctgtg tatgatctcg tggctgtgct gtgtcccaaa gggcctctga gaatgctggt     1260

agaaactgcc caggagagaa atgagcccat attccctgcc ctgatatact catctgccat     1320

ggtgtggacg gttggcatgg cgaagctgga cccctcctct cagggtgccc tccagctccc     1380

ctacgacccg gagatggaag actcctatga cagttttggg gagccttcat accccgaagt     1440

ctttgagcct cccttgactg gctacccagg ggaggagctg gaggaagagg aggaaagggg     1500

cgtgaagctt ggcctcgggg acttcatctt ctacagtgtg ctggtgggca aggcggctgc     1560

cacgggcagc ggggactgga ataccacgct ggcctgcttc gtggccatcc tcattggctt     1620

gtgtctgacc ctcctgctgc ttgctgtgtt caagaaggcg ctgcccgccc tccccatctc     1680

catcacgttc gggctcatct tttacttctc cacggacaac ctggtgcggc cgttcatgga     1740

caccctggcc tcccatcagc tctacatctg agggacatgg tgtgccacag gctgcaagct     1800

gcagggaatt ttcattggat gcagttgtat agttttacac tctagtgcca tatattttta     1860

agacttttct ttccttaaaa aataaagtac gtgtttactt ggtgaggagg aggcagaacc     1920

agctctttgg tgccagctgt ttcatcacca gactttggct cccgctttgg ggagcgcctc     1980

gcttcacgga caggaagcac agcaggttta tccagatgaa ctgagaaggt cagattaggg     2040

cggggagaag agcatccggc atgagggctg agatgcgcaa agagtgtgct cgggagtggc     2100

ccctggcacc tgggtgctct ggctggagag gaaaagccag ttccctacga ggagtgttcc     2160

caatgctttg tccatgatgt ccttgttatt ttattgcctt tagaaactga gtcctgttct     2220

tgttacggca gtcacactgc tgggaagtgg cttaatagta atatcaataa atagatgagt     2280

cctgttagaa tcttgaaaa                                                  2299


<210>  5
<211>  467
<212>  PRT
<213>  Homo sapines

<400>  5

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  6
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  7
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  8
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr Pro 
                325                 330                 335     


Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu Glu 
            340                 345                 350         


Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
        355                 360                 365             


Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp Trp 
    370                 375                 380                 


Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
385                 390                 395                 400 


Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu Pro 
                405                 410                 415     


Ile Ser Ile Thr 
            420 


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer hPS1-F5

<400>  9
agacccggaa gctcaaagga                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer hPS1-R5

<400>  10
ttcctcactg aacccgccat                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer hPS2-F5

<400>  11
aagtgtccgg gattcagacc tc                                                22


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer hPS2-R5

<400>  12
tcgctgtcag aggccatgaa                                                   20


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer NCT-104

<400>  13
acaggtggcc ttaagaactt cat                                               23


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer NCT-204

<400>  14
ccacctggtt ccgtacagac                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer hPen2-F1

<400>  15
tccttgtccc agcctacaca                                                   20


<210>  16
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer hPen2-R1

<400>  16
agcactatca cccagaagag ga                                                22


