                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS FOR TREATING SPINAL CORD INJURY

<130> 701039-092150WOPT

<140> PCT/US2019/033303
<141> 2019-05-21

<150> 62/676,464
<151> 2018-05-25

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 3351
<212> DNA
<213> Rattus sp.

<400> 1
atgctcaaca acctgacgga ctgcgaggac ggcgatgggg gagccaaccc gggtgacggc       60

aatcccaagg agagcagccc cttcatcaac agcacggaca cggagaaggg gagagagtat      120

gatggcagga acatggccct gtttgaggag gagatggaca ccagccccat ggtatcctcc      180

ctgctcagtg ggctggccaa ctacaccaac ctgcctcagg gaagcaaaga gcacgaagaa      240

gcagaaaaca atgagggcgg aaagaagaag ccggtgcagg ccccacgcat gggcaccttc      300

atgggcgtgt acctcccgtg cctgcagaac atctttggtg ttatcctctt tctgcggctc      360

acttgggtgg tgggaatcgc aggcatcatg gagtccttct gcatggtctt catctgctgc      420

tcctgcacga tgctcacagc catttccatg agcgcaattg caaccaatgg tgttgtgcct      480

gctggtggct cctactacat gatttccagg tctctgggcc cggagtttgg gggcgccgtg      540

ggcctctgct tctacctggg cactaccttt gctggggcta tgtacatcct gggcaccatc      600

gagatcctgc tggcttacct cttcccagcg atggccatct tcaaggcaga agatgccagt      660

ggggaggcag ccgccatgtt gaataacatg cgggtgtatg gcacctgtgt gctcacctgc      720

atggccaccg tagtctttgt gggcgtcaag tacgtgaaca agtttgccct ggtcttcctg      780

ggttgcgtga tcctctccat cctggccatc tacgcagggg tcatcaagtc tgccttcgat      840

ccacccaatt tcccgatttg cctcctgggg aaccgcacgc tgtctcgcca tggctttgat      900

gtctgtgcca agctggcttg ggaaggaaat gagacagtga ccacacggct ctggggccta      960

ttctgttcct cccgcctcct caatgccacc tgtgatgagt acttcacccg aaacaatgtc     1020

acagagatcc agggcattcc tggtgctgca agtggcctca tcaaagagaa cctgtggagt     1080

tcctacctga ccaagggggt gatcgtggag aggcgtggga tgccctctgt gggcctggca     1140

gatggtaccc ccgttgacat ggaccacccc tatgtcttca gtgatatgac ctcctacttc     1200

accctgcttg ttggcatcta tttcccctca gtcacaggga tcatggctgg ctcgaaccgg     1260

tccggagacc tgcgggatgc ccagaagtct atccctactg gaactatctt ggccattgct     1320

acgacctctg ctgtctacat cagctctgtt gttctgttcg gagcctgcat cgaaggggtc     1380

gtcctacggg acaagtttgg ggaagctgtg aatggcaatc tggtggtggg caccctggcc     1440

tggccttctc cttgggtcat tgtcataggc tctttcttct ctacctgcgg agctggacta     1500

cagagcctca caggggcccc acgcctgctg caggccatct cccgggatgg catagtgccc     1560

ttcctgcagg tctttggcca tggcaaagcc aacggagagc caacctgggc gctgctgctg     1620

actgcctgca tctgtgagat cggcatcctc atcgcctccc tggatgaggt cgcccctatc     1680

ctttccatgt tcttcctgat gtgttacatg tttgtgaact tggcttgcgc ggtgcagaca     1740

ctgctgagga cgcccaactg gaggccacgc ttccgatatt accactggac cctctccttc     1800

ctgggcatga gcctctgcct ggccctgatg ttcatttgct cctggtatta tgcgctggta     1860

gctatgctca tcgctggcct catctataag tacatcgagt accggggggc agagaaggag     1920

tggggggatg ggatccgagg cctgtctctc agtgcagctc gctatgctct cttgcgtctg     1980

gaggaaggac ccccgcatac aaagaactgg aggccccagc tactggtgct ggtgcgtgtg     2040

gaccaggacc agaacgtggt gcacccgcag ctgctgtcct tgacctccca gctcaaggca     2100

gggaagggcc tgaccattgt gggctctgtc cttgagggca cctttctgga caaccaccct     2160

caggctcagc gggcagagga gtctatccgg cgcctgatgg aggctgagaa ggtgaagggc     2220

ttctgccagg tagtgatctc ctccaacctg cgtgacggtg tgtcccacct gatccaatcc     2280

gggggcctcg ggggcctgca acacaacact gtgctagtgg gctggcctcg caactggcga     2340

cagaaggagg atcatcagac atggaggaac ttcatcgaac tcgtccggga aactacagct     2400

ggccacctcg ccctgctggt caccaagaat gtttccatgt tccccgggaa ccctgagcgt     2460

ttctctgagg gcagcattga cgtgtggtgg atcgtgcacg acgggggcat gctcatgctg     2520

ttgcccttcc tcctgcgtca ccacaaggtc tggaggaaat gcaaaatgcg gatcttcacc     2580

gtggcgcaga tggatgacaa cagcattcag atgaagaaag acctgaccac gtttctgtac     2640

cacttacgaa ttactgcaga ggtggaagtc gtggagatgc acgagagcga catctcagca     2700

tacacctacg agaagacatt ggtaatggaa caacgttctc agatcctcaa acagatgcac     2760

ctcaccaaga acgagcggga acgggagatc cagagcatca cagatgaatc tcggggctcc     2820

attcggagga agaatccagc caacactcgg ctccgcctca atgttcccga agagacagct     2880

tgtgacaacg aggagaagcc agaagaggag gtgcagctga tccatgacca gagtgctccc     2940

agctgcccta gcagctcgcc gtctccaggg gaggagcctg agggggaggg ggagacagac     3000

ccagagaagg tgcatctcac ctggaccaag gataagtcag cggctcagaa gaacaaaggc     3060

cccagtcccg tctcctcgga ggggatcaag gacttcttca gcatgaagcc ggagtgggaa     3120

aacttgaacc agtccaacgt gcggcgcatg cacacagctg tgcggctgaa cgaggtcatc     3180

gtgaataaat cccgggatgc caagttggtg ttgctcaaca tgcccgggcc tccccgcaac     3240

cgcaatggag atgaaaacta catggagttc ctggaggtcc tcactgagca actggaccgg     3300

gtgatgctgg tccgcggtgg tggccgagag gtcatcacca tctactcctg a              3351


<210> 2
<211> 1439
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atggccaact tcacacctgt caatggcagc tcgggcaatc agtccgtgcg cctggtcacg       60

tcatcatccc acaatcgcta tgagacggtg gaaatggtct tcattgccac agtgacaggc      120

tccctgagcc tggtgactgt cgtgggcaac atcctggtga tgctgtccat caaggtcaac      180

aggcagctgc agacagtcaa caactacttc ctcttcagcc tggcgtgtgc tgatctcatc      240

ataggcgcct tctccatgaa cctctacacc gtgtacatca tcaagggcta ctggcccctg      300

ggcgccgtgg tctgcgacct gtggctggcc ctggactgcg tggtgagcaa cgcctccgtc      360

atgaaccttc tcatcatcag ctttgaccgc tacttctgcg tcaccaagcc tctcacctac      420

cctgcccggc gcaccaccaa gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc      480

ttcgtgctct gggcgcctgc catcttgttc tggcagtttg tggtgggtaa gcggacggtg      540

cccgacaacc agtgcttcat ccagttcctg tccaacccag cagtgacctt tggcacagcc      600

attgctggct tctacctgcc tgtggtcatc atgacggtgc tgtacatcca catctccctg      660

gccagtcgca gccgagtcca caagcaccgg cccgagggcc cgaaggagaa gaaagccaag      720

acgctggcct tcctcaagag cccactaatg aagcagagcg tcaagaagcc cccgcccggg      780

gaggccgccc gggaggagct gcgcaatggc aagctggagg aggccccccc gccagcgctg      840

ccaccgccac cgcgccccgt ggctgataag gacacttcca atgagtccag ctcaggcagt      900

gccacccaga acaccaagga acgcccagcc acagagctgt ccaccacaga ggccaccacg      960

cccgccatgc ccgcccctcc cctgcagccg cgggccctca acccagcctc cagatggtcc     1020

aagatccaga ttgtgacgaa gcagacaggc aatgagtgtg tgacagccat tgagattgtg     1080

cctgccacgc cggctggcat gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc     1140

gctcgcaacc aggtgcgcaa gaagcggcag atggcggccc gggagcgcaa agtgacacga     1200

acgatctttg ccattctgct ggccttcatc ctcacctgga cgccctacaa cgtcatggtc     1260

ctggtgaaca ccttctgcca gagctgcatc cctgacacgg tgtggtccat tggctactgg     1320

ctctgctacg tcaacagcac catcaaccct gcctgctatg ctctgtgcaa cgccaccttt     1380

aaaaagacct tccggcacct gctgctgtgc cagtatcgga acatcggcac tgccaggcg      1439


<210> 3
<211> 427
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 


Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu 
                405                 410                 415     


Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         


<210> 4
<211> 3639
<212> DNA
<213> Homo sapiens

<400> 4
atggagccgc ggcccacggc gccctcctcc ggcgccccgg gactggccgg ggtcggggag       60

acgccgtcag ccgctgcgct ggccgcagcc agggtggaac tgcccggcac ggctgtgccc      120

tcggtgccgg aggatgctgc gcccgcgagc cgggacggcg gcggggtccg cgatgagggc      180

cccgcggcgg ccggggacgg gctgggcaga cccttggggc ccaccccgag ccagagccgt      240

ttccaggtgg acctggtttc cgagaacgcc gggcgggccg ctgctgcggc ggcggcggcg      300

gcggcggcag cggcggcggc tggtgctggg gcgggggcca agcagacccc cgcggacggg      360

gaagccagcg gcgagagcga gccggctaaa ggcagcgagg aagccaaggg ccgcttccgc      420

gtgaacttcg tggacccagc tgcctcctcg tcggctgaag acagcctgtc agatgctgcc      480

ggggtcggag tcgacgggcc caacgtgagc ttccagaacg gcggggacac ggtgctgagc      540

gagggcagca gcctgcactc cggcggcggc ggcggcagtg ggcaccacca gcactactat      600

tatgataccc acaccaacac ctactacctg cgcaccttcg gccacaacac catggacgct      660

gtgcccagga tcgatcacta ccggcacaca gccgcgcagc tgggcgagaa gctgctccgg      720

cctagcctgg cggagctcca cgacgagctg gaaaaggaac cttttgagga tggctttgca      780

aatggggaag aaagtactcc aaccagagat gctgtggtca cgtatactgc agaaagtaaa      840

ggagtcgtga agtttggctg gatcaagggt gtattagtac gttgtatgtt aaacatttgg      900

ggtgtgatgc ttttcattag attgtcatgg attgtgggtc aagctggaat aggtctatca      960

gtccttgtaa taatgatggc cactgttgtg acaactatca caggattgtc tacttcagca     1020

atagcaacta atggatttgt aagaggagga ggagcatatt atttaatatc tagaagtcta     1080

gggccagaat ttggtggtgc aattggtcta atcttcgcct ttgccaacgc tgttgcagtt     1140

gctatgtatg tggttggatt tgcagaaacc gtggtggagt tgcttaagga acattccata     1200

cttatgatag atgaaatcaa tgatatccga attattggag ccattacagt cgtgattctt     1260

ttaggtatct cagtagctgg aatggagtgg gaagcaaaag ctcagattgt tcttttggtg     1320

atcctacttc ttgctattgg tgatttcgtc ataggaacat ttatcccact ggagagcaag     1380

aagccaaaag ggttttttgg ttataaatct gaaatattta atgagaactt tgggcccgat     1440

tttcgagagg aagagacttt cttttctgta tttgccatct tttttcctgc tgcaactggt     1500

attctggctg gagcaaatat ctcaggtgat cttgcagatc ctcagtcagc catacccaaa     1560

ggaacactcc tagccatttt aattactaca ttggtttacg taggaattgc agtatctgta     1620

ggttcttgtg ttgttcgaga tgccactgga aacgttaatg acactatcgt aacagagcta     1680

acaaactgta cttctgcagc ctgcaaatta aactttgatt tttcatcttg tgaaagcagt     1740

ccttgttcct atggcctaat gaacaacttc caggtaatga gtatggtgtc aggatttaca     1800

ccactaattt ctgcaggtat attttcagcc actctttctt cagcattagc atccctagtg     1860

agtgctccca aaatatttca ggctctatgt aaggacaaca tctacccagc tttccagatg     1920

tttgctaaag gttatgggaa aaataatgaa cctcttcgtg gctacatctt aacattctta     1980

attgcacttg gattcatctt aattgctgaa ctgaatgtta ttgcaccaat tatctcaaac     2040

ttcttccttg catcatatgc attgatcaat ttttcagtat tccatgcatc acttgcaaaa     2100

tctccaggat ggcgtcctgc attcaaatac tacaacatgt ggatatcact tcttggagca     2160

attctttgtt gcatagtaat gttcgtcatt aactggtggg ctgcattgct aacatatgtg     2220

atagtccttg ggctgtatat ttatgttacc tacaaaaaac cagatgtgaa ttggggatcc     2280

tctacacaag ccctgactta cctgaatgca ctgcagcatt caattcgtct ttctggagtg     2340

gaagaccacg tgaaaaactt taggccacag tgtcttgtta tgacaggtgc tccaaactca     2400

cgtccagctt tacttcatct tgttcatgat ttcacaaaaa atgttggttt gatgatctgt     2460

ggccatgtac atatgggtcc tcgaagacaa gccatgaaag agatgtccat cgatcaagcc     2520

aaatatcagc gatggcttat taagaacaaa atgaaggcat tttatgctcc agtacatgca     2580

gatgacttga gagaaggtgc acagtatttg atgcaggctg ctggtcttgg tcgtatgaag     2640

ccaaacacac ttgtccttgg atttaagaaa gattggttgc aagcagatat gagggatgtg     2700

gatatgtata taaacttatt tcatgatgct tttgacatac aatatggagt agtggttatt     2760

cgcctaaaag aaggtctgga tatatctcat cttcaaggac aagaagaatt attgtcatca     2820

caagagaaat ctcctggcac caaggatgtg gtagtaagtg tggaatatag taaaaagtcc     2880

gatttagata cttccaaacc actcagtgaa aaaccaatta cacacaaagt tgaggaagag     2940

gatggcaaga ctgcaactca accactgttg aaaaaagaat ccaaaggccc tattgtgcct     3000

ttaaatgtag ctgaccaaaa gcttcttgaa gctagtacac agtttcagaa aaaacaagga     3060

aagaatacta ttgatgtctg gtggcttttt gatgatggag gtttgacctt attgatacct     3120

taccttctga cgaccaagaa aaaatggaaa gactgtaaga tcagagtatt cattggtgga     3180

aagataaaca gaatagacca tgaccggaga gcgatggcta ctttgcttag caagttccgg     3240

atagactttt ctgatatcat ggttctagga gatatcaata ccaaaccaaa gaaagaaaat     3300

attatagctt ttgaggaaat cattgagcca tacagacttc atgaagatga taaagagcaa     3360

gatattgcag ataaaatgaa agaagatgaa ccatggcgaa taacagataa tgagcttgaa     3420

ctttataaga ccaagacata ccggcagatc aggttaaatg agttattaaa ggaacattca     3480

agcacagcta atattattgt catgagtctc ccagttgcac gaaaaggtgc tgtgtctagt     3540

gctctctaca tggcatggtt agaagctcta tctaaggacc taccaccaat cctcctagtt     3600

cgtgggaatc atcagagtgt ccttaccttc tattcataa                            3639


<210> 5
<211> 428
<212> PRT
<213> Mus sp.

<400> 5
Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Asp Thr Ser Lys Val Ser Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Glu Glu Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser 
385                 390                 395                 400 


Thr Asp Ser Pro Pro Gly Ile Asp Leu His Asn Gln Ala Ser Val Pro 
                405                 410                 415     


Leu Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425             


