                         SEQUENCE LISTING

<110>  Centre national de la recherche scientifique
       Institut National de la Sant Et de la Recherche Mdicale
       Universit de Montpellier
       Centre Hospitalier Universitaire de Nmes
 
<120>  Diagnosis method of multiple slerosis

<130>  BR 103099/RIM/ANR

<150>  EP 18305630.8
<151>  2018-05-22

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deriverd from hSDC1

<400>  1

Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro Gly Leu Thr Ala 
1               5                   10                  15      


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from hsDC27

<400>  2

His Cys Asn Ser Gly Leu Leu Val 
1               5               


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from hCECR1

<400>  3

Leu Leu Pro Val Tyr Glu Leu Ser Gly Glu His His Asp Glu Glu Trp 
1               5                   10                  15      


Ser Val 
        


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from hNGAL

<400>  4

Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
1               5                   10  


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from hIGKC

<400>  5

Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
1               5                   10                  15      


Gln Asp Ser 
            


<210>  6
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Gln Arg Leu Val Gly Ser Lys Cys Gln Cys Leu Ala Pro Ser 
1               5                   10                  15      


Leu Pro His Leu Glu Leu Ser Leu Gly Gly Gly Gly Ala Ala Gly Glu 
            20                  25                  30          


Gly Arg Ala Glu Ser Leu Asp Glu Ser Glu Ala Met Ile Pro Gln Ile 
        35                  40                  45              


Val Ala Thr Asn Leu Pro Pro Glu Asp Gln Asp Gly Ser Gly Asp Asp 
    50                  55                  60                  


Ser Asp Asn Phe Ser Gly Ser Gly Ala Gly Ala Leu Gln Asp Ile Thr 
65                  70                  75                  80  


Leu Ser Gln Gln Thr Pro Ser Thr Trp Lys Asp Thr Gln Leu Leu Thr 
                85                  90                  95      


Ala Ile Pro Thr Ser Pro Glu Pro Thr Gly Leu Glu Ala Thr Ala Ala 
            100                 105                 110         


Ser Thr Ser Thr Leu Pro Ala Gly Glu Gly Pro Lys Glu Gly Glu Ala 
        115                 120                 125             


Val Val Leu Pro Glu Val Glu Pro Gly Leu Thr Ala Arg Glu Gln Glu 
    130                 135                 140                 


Ala Thr Pro Arg Pro Arg Glu Thr Thr Gln Leu Pro Thr Thr His Leu 
145                 150                 155                 160 


Ala Ser Thr Thr Thr Ala Thr Thr Ala Gln Glu Pro Ala Thr Ser His 
                165                 170                 175     


Pro His Arg Asp Met Gln Pro Gly His His Glu Thr Ser Thr Pro Ala 
            180                 185                 190         


Gly Pro Ser Gln Ala Asp Leu His Thr Pro His Thr Glu Asp Gly Gly 
        195                 200                 205             


Pro Ser Ala Thr Glu Arg Ala Ala Glu Asp Gly Ala Ser Ser Gln Leu 
    210                 215                 220                 


Pro Ala Ala Glu Gly Ser Gly Glu Gln Asp Phe Thr Phe Glu Thr Ser 
225                 230                 235                 240 


Gly Glu Asn Thr Ala Val Val Ala Val Glu Pro Asp Arg Arg Asn Gln 
                245                 250                 255     


Ser Pro Val Asp Gln Gly Ala Thr Gly Ala Ser Gln Gly Leu Leu Asp 
            260                 265                 270         


Arg Lys Glu Val Leu Gly Gly Val Ile Ala Gly Gly Leu Val Gly Leu 
        275                 280                 285             


Ile Phe Ala Val Cys Leu Val Gly Phe Met Leu Tyr Arg Met Lys Lys 
    290                 295                 300                 


Lys Asp Glu Gly Ser Tyr Ser Leu Glu Glu Pro Lys Gln Ala Asn Gly 
305                 310                 315                 320 


Gly Ala Tyr Gln Lys Pro Thr Lys Gln Glu Glu Phe Tyr Ala 
                325                 330                 


<210>  7
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Ser Lys Arg Gln Asn 
    210                 215                 220                 


Thr Gly Leu Arg Ser Cys Pro Cys Thr Thr Pro His Trp Leu Asn Ser 
225                 230                 235                 240 


Thr Ala His Ala Trp Asn Leu Thr Glu Thr His Gln Leu His Phe Thr 
                245                 250                 255     


Ser Leu Gly Pro Thr Pro Ser Leu Pro Leu Ala Gly Val Leu Leu Thr 
            260                 265                 270         


Pro Leu Pro Gln Gly His Pro Pro Leu Pro Ile Ser Phe Ser Arg Leu 
        275                 280                 285             


Pro Leu Pro Pro Leu Leu Ala Lys Thr His Arg Ile Ser Phe Cys Arg 
    290                 295                 300                 


Gln Arg Arg Lys Ser Cys Gly Ala Cys Arg Ala Leu Ser Leu Gln Leu 
305                 310                 315                 320 


Pro Gln Gly Gly Gly Gly Gln His His Pro His Pro Gly Gly Leu Pro 
                325                 330                 335     


Lys Thr Gly Ala Cys Leu Leu Pro Leu Ser Gln His Leu Arg Glu Leu 
            340                 345                 350         


His Tyr Ser Pro Gly Leu His Pro His Pro Ala Asp His Pro Arg Glu 
        355                 360                 365             


Ser Glu Thr Trp Gln Pro Gln Leu Gln Ser His Pro Leu Val Arg Ala 
    370                 375                 380                 


Leu Ser Cys Val His Val Thr Glu Cys Leu Phe Glu Thr Gly Arg Asp 
385                 390                 395                 400 


Glu Asp Lys Tyr Gly 
                405 


<210>  8
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu Arg Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  9
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ala Leu Pro Ala His Arg Pro Pro Ala His Ile Gln Gly Asn 
1               5                   10                  15      


Gln Lys Lys Glu Thr Ala Gln Gly Arg His Arg Gly Ser Arg Cys Pro 
            20                  25                  30          


Cys Gln Arg Pro Ser Ser His His Ser Ala Cys Phe Leu Gly Pro Glu 
        35                  40                  45              


Ile Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala 
    50                  55                  60                  


Leu His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro 
65                  70                  75                  80  


Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe 
                85                  90                  95      


Gln Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg 
            100                 105                 110         


Glu Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys 
        115                 120                 125             


Glu Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys 
    130                 135                 140                 


Cys Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu 
145                 150                 155                 160 


Phe Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu 
                165                 170                 175     


Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe 
            180                 185                 190         


Lys Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly 
        195                 200                 205             


Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe 
    210                 215                 220                 


Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro 
225                 230                 235                 240 


Ile Asp Gln Cys Ile Asp Gly 
                245         


<210>  10
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Arg Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Pro Arg Leu Gly Lys Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ser Ala 
225                 230                 235                 240 


Arg Gln Ser Thr Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp 
                245                 250                 255     


Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Ser Glu Gly Gly Gly 
        275                 280 


<210>  11
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  derived from CECR1_2

<400>  11

Ser Gln Val Phe Asn Ile Leu 
1               5           


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from CHI3L2

<400>  12

Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
1               5                   10  


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from CHI3L2

<400>  13

Leu Val Cys Tyr Tyr Thr Ser Trp Ser Gln Tyr 
1               5                   10      


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from CHI3L1

<400>  14

Leu Leu Leu Thr Ala Gly Val Ser Ala Gly 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from CHI3L1

<400>  15

Gly Pro Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile 
1               5                   10                  15      


His 
    


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from CHIT1

<400>  16

Val Gly Ala Pro Ala Thr Gly Ser Gly Thr Pro Gly Pro Phe Thr 
1               5                   10                  15  


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from CH1T1

<400>  17

Asp Asn Gln Trp Val Gly Phe Asp Asp Val Glu Ser Phe 
1               5                   10              


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  defrived from FHR1

<400>  18

Asn His Gly Ile Leu Tyr Asp Glu Glu 
1               5                   


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from IGKC

<400>  19

Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
1               5                   10                  15  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from LIZ1

<400>  20

Trp Glu Ser Gly Tyr Asn Thr 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from RELN

<400>  21

Val Ile Val Leu Leu Pro Gln 
1               5           


