                         SEQUENCE LISTING

<110>  The Governors of the University of Alberta
 
<120>  INNOCUOUS, STRUCTURED SCAFFOLDS FOR STRUCTURE-BASED AMYLOID 
       DISEASE VACCINES AND ANTIGENS

<130>  PAT 89412W-90

<150>  US 62/674,916
<151>  2018-05-22

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figs 3, 32

<400>  1

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Lys Asp Ile Arg 
1               5                   10                  15      


Thr Glu Glu Arg Ala Arg Val Gln Leu Asn Gly Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Glu Thr Val Val Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Ala Gly Gly Gly Gly Gly Asn Ser Ala Lys Asp Ile Arg Thr Glu 
                85                  90                  95      


Glu Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala Ala Leu 
            100                 105                 110         


His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val Glu Thr 
        115                 120                 125             


Val Val Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu Tyr Gly 
    130                 135                 140                 


Gly Lys Gly Phe Trp Asp Asn His His His His His His 
145                 150                 155         


<210>  2
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figs. 4, 34, 44, 46, 47

<400>  2

Met Val Lys Ser His Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala 
1               5                   10                  15      


Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly 
            20                  25                  30          


Gly Trp Asn Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly 
        35                  40                  45              


Gly Asn Arg Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His 
    50                  55                  60                  


Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His 
65                  70                  75                  80  


Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly Gly Trp Gly Gln Gly 
                85                  90                  95      


Gly Thr His Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met 
            100                 105                 110         


Lys His Val Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu 
        115                 120                 125             


Gly Gly Tyr Met Leu Gly Ser Ala Met Ser Arg Pro Leu Ile His Phe 
    130                 135                 140                 


Gly Asn Asp Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met Tyr Arg Tyr 
145                 150                 155                 160 


Pro Asn Gln Val Tyr Tyr Arg Pro Val Asp Gln Tyr Asn Asn Gln Asn 
                165                 170                 175     


Thr Phe Val His Asp Cys Val Asn Ile Thr Val Lys Gln His Thr Val 
            180                 185                 190         


Thr Thr Thr Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Ile Lys Met 
        195                 200                 205             


Met Glu Arg Val Val Glu Gln Met Cys Ile Thr Gln Tyr Gln Arg Glu 
    210                 215                 220                 


Ser Gln Ala Tyr Tyr Gln Arg Gly Ala Ser Val Ile Leu Phe Ser Ser 
225                 230                 235                 240 


Pro Pro Val Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250                 255     


<210>  3
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figs. 6, 34

<400>  3

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Lys Tyr Ile Asp 
1               5                   10                  15      


Thr Glu Asp Arg Ala Glu Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Glu Lys Val Asn Gly Lys His Glu Ser Arg Val Arg Leu Ile Gly Asn 
    50                  55                  60                  


Glu Tyr Gly Gly Lys Gly Phe Trp Asp Asn Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ala Ala Gly Gly Gly Gly Gly Asn Ser Ala Lys Tyr Ile Asp Thr 
                85                  90                  95      


Glu Asp Arg Ala Glu Val Gln Leu Gly Asn Val Val Thr Ala Ala Ala 
            100                 105                 110         


Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val Glu 
        115                 120                 125             


Lys Val Asn Gly Lys His Glu Ser Arg Val Leu Ile Gly Asn Glu Tyr 
    130                 135                 140                 


Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
145                 150                 155             


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  4

Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Met His Trp Val 
1               5                   10                  15      


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro 
            20                  25                  30          


Ser Asp Ser Glu Thr Lys Leu Asn Gln Gln Phe Lys Asp Lys Ala Thr 
        35                  40                  45              


Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Thr Ser 
    50                  55                  60                  


Pro Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys Ala Arg Gly Lys Met 
65                  70                  75                  80  


Gly Gly Arg Phe Tyr Phe Asp Tyr Leu Gly Gln Gly Thr Thr Leu Thr 
                85                  90                  95      


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
            100                 105                 110     


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  5

Tyr Ser Phe Thr Ser Tyr Trp Met His 
1               5                   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  6

Met Ile Asp Pro Ser Asp Ser Glu Thr Lys Leu Asn Gln Gln Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  7
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  7

Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Val Trp Tyr 
1               5                   10                  15      


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
            20                  25                  30          


Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Phe Gly 
        35                  40                  45              


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
    50                  55                  60                  


Asp Tyr Phe Cys Gln Gln Phe Ser Ser Tyr Pro Tyr Thr Phe Gly Gly 
65                  70                  75                  80  


Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
                85                  90                  95      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  8

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Val 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  9

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  10

Gln Gln Phe Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  11
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 33

<400>  11

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Lys Asp Ile Arg 
1               5                   10                  15      


Thr Glu Glu Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Glu Thr Val Val Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  12
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figs 35, 36

<400>  12

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  13
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 35

<400>  13

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Val Phe Ile Glu 
1               5                   10                  15      


Thr Asp Gly Ser Ala Lys Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Val Phe Val Glu Gly Asp Gly Ser Ser Lys Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  14
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 36

<400>  14

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Arg Ala Asp Asp Ile Tyr 
1               5                   10                  15      


Thr Val Glu His Ala Lys Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Arg Val 
        35                  40                  45              


Asp Thr Val Tyr Gly Val Gly His Ser Lys Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  15
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figs. 37, 38

<400>  15

Val Gln Ile Val Tyr Lys Asp Leu Pro Val Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        35                  40                  45              


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    50                  55                  60                  


Lys Ile Glu Thr His Lys Leu Thr Phe 
65                  70              


<210>  16
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 37

<400>  16

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Lys Ala Glu Lys Ile Asp 
1               5                   10                  15      


Thr Lys Asp Arg Ala Gln Val Lys Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Lys Val 
        35                  40                  45              


Glu Lys Val Asp Gly Lys Asp Arg Ser Gln Val Lys Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  17
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 38

<400>  17

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Lys Ala Glu Lys Ile Asp 
1               5                   10                  15      


Thr Lys Glu Asp Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Lys Val 
        35                  40                  45              


Glu Lys Val Asp Gly Lys Gly Asp Ser Arg Val Gln Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  18
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figs 39, 40, 41, 42

<400>  18

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  19
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 39

<400>  19

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Gln Val Ile Asn 
1               5                   10                  15      


Thr Gly Gly Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Val Ala Thr Ile Ala Glu Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Gln Val Val Asn Gly Gly Gly Glu Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  20
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 40

<400>  20

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Lys Asp Ile Lys 
1               5                   10                  15      


Thr Val Glu Gly Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Glu Thr Val Lys Gly Val Glu Gly Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  21
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 41

<400>  21

Met Lys Ile Asp Ala Ile Val Gly Lys Asn Gln Ala Thr Asp Ile Arg 
1               5                   10                  15      


Thr Glu Glu Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Lys Asn Gln Val 
        35                  40                  45              


Thr Thr Val Val Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  22
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 42

<400>  22

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Lys Ala Val Glu Ile Ala 
1               5                   10                  15      


Thr Glu Glu Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Lys Val 
        35                  40                  45              


Val Glu Val Ala Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn His His His His His His 
65                  70                  75                  


<210>  23
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 43

<400>  23

Met Asn Val Ser Gln Ser Asn Ser Phe Gly Phe Trp Asp Gly Thr Ser 
1               5                   10                  15      


Thr Gln Ala Glu Ile Thr His Ser Phe Asp His Tyr Ile Gly Ser Ala 
            20                  25                  30          


Phe Asp Ala Ser Asn Asn Asn Val Ala Val Thr Gly Asn Val Ser Ala 
        35                  40                  45              


Thr Leu Asn Val Leu Ala Gly Asp Asp Lys Val Ser Ile Asp Gly Asn 
    50                  55                  60                  


Val Glu Asp Val Leu Val Ala Ala Asn Val Ala Val Leu Asp Met Gly 
65                  70                  75                  80  


Thr Gly Asn Asp Gln Leu Tyr Val Ala Gly Asp Val Leu Gly Lys Ile 
                85                  90                  95      


Asp Ala Gly Thr Gly Asn Asp Glu Ile Tyr Ile Lys Gly Asp Val Ser 
            100                 105                 110         


Ala Ala Val Asp Ala Gly Thr Gly Asn Asp Glu Val Tyr Ile Gly Gly 
        115                 120                 125             


Asn Leu Ser Gly Asp Leu Asp Ala Gly Thr Asp Asn Asp Asn Ile Gln 
    130                 135                 140                 


Ile Gly Gly Asp Val Asn Ala Ala Leu Asn Ala Gly Thr Gly Asn Asp 
145                 150                 155                 160 


Asn Leu Ile Ile Gly His Asp Val Ser Gly Ile Val Asn Met Gly Thr 
                165                 170                 175     


Asp Asn Asp Thr Val Glu Val Gly Arg Thr Ile Asn Ala Ser Gly Lys 
            180                 185                 190         


Val Leu Leu Asp Thr Gly Asp Asp Ser Leu Leu Val Ser Gly Asp Leu 
        195                 200                 205             


Phe Gly Glu Val Asp Gly Gly Thr Gly Asn Asp Thr Ile Ile Ile Ala 
    210                 215                 220                 


Gly Lys Val Ser Gly Asn Ile Gln Gly Gly Thr Gly Asn Asp Ile Val 
225                 230                 235                 240 


Arg Val Gln Ser Gln Val Trp Ala Glu Ala Asn Ile Ser Leu Gly Thr 
                245                 250                 255     


Gly Asp Asp Val Leu Ile Val Glu His Glu Leu His Gly Thr Val Ala 
            260                 265                 270         


Gly Asn Glu Gly Asp Asp Ser Ile Tyr Leu Lys Phe Tyr Thr Lys Glu 
        275                 280                 285             


Gln Tyr Asn Asn Asn Ser Asp Leu Arg Asn Arg Val Ala Asn Phe Glu 
    290                 295                 300                 


His Ile Arg Val Ser Asp Gly Val Val Lys Gly Ser Pro Ala Asp Phe 
305                 310                 315                 320 


Ala Asp Tyr 
            


<210>  24
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 43

<400>  24

Met Ala His His His His His His Val Gly Thr Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Asp Leu Lys Val Leu Ala Gly Asp Asp Lys Val Ser Ile Asp 
            20                  25                  30          


Gly Asn Val Ser Gly Ala Leu Asp Met Gly Thr Gly Asn Asp Gln Leu 
        35                  40                  45              


Tyr Val Ala Gly Asp Val Leu Gly Lys Ile Asp Ala Gly Thr Gly Asn 
    50                  55                  60                  


Asp Glu Ile Tyr Ile Lys Gly Asp Val Ser Ala Ala Val Asp Ala Gly 
65                  70                  75                  80  


Thr Gly Asn Asp Glu Val Tyr Ile Gly Gly Asn Leu Ser Lys 
                85                  90                  


<210>  25
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 44

<400>  25

Met Ala His His His His His His Val Gly Thr Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Asp Leu Lys Val Leu Ala Gly Asp Asp Lys Val Ser Ile Asp 
            20                  25                  30          


Gly Asn Val Ser Gly Ala Leu Asp Met Gly Thr Gly Asn Asp Gln Leu 
        35                  40                  45              


Tyr Val Ala Gly Asp Val Leu Gly Lys Ile Asp Ala Gly Thr Gly Leu 
    50                  55                  60                  


Asp Ser Ile Met Ile Lys Gly Asp Val Ser Ala Ala Val Asp Ala Gly 
65                  70                  75                  80  


Thr Gly Gln Asp Asn Val Gln Ile Gly Gly Asn Leu Ser Lys 
                85                  90                  


<210>  26
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 45, 46

<400>  26

Met Ala His His His His His His Val Gly Thr Asn Thr Gly Gly Val 
1               5                   10                  15      


Leu Val Ile Thr Asp Thr Ile Ile Val Lys Ser Gly Gln Thr Tyr Asp 
            20                  25                  30          


Gly Lys Gly Ile Lys Ile Ile Ala Gln Gly Met Gly Asp Gly Ser Gln 
        35                  40                  45              


Ser Glu Asn Gln Lys Pro Ile Phe Lys Leu Glu Lys Gly Ala Asn Leu 
    50                  55                  60                  


Lys Asn Val Ile Ile Gly Ala Pro Gly Cys Asp Gly Ile His Cys Tyr 
65                  70                  75                  80  


Gly Asp Asn Val Val Glu Asn Val Val Trp Glu Asp Val Gly Ala Asp 
                85                  90                  95      


Ala Leu Thr Val Lys Ser Glu Gly Val Val Glu Val Ile Gly Gly Ser 
            100                 105                 110         


Ala Lys Glu Ala Ala Asp Lys Val Phe Gln Leu Asn Ala Pro Cys Thr 
        115                 120                 125             


Phe Lys Val Lys Asn Phe Thr Ala Thr Asn Ile Gly Lys Leu Val Arg 
    130                 135                 140                 


Gln Asn Gly Asn Thr Thr Phe Lys Val Val Ile Tyr Leu Glu Asp Val 
145                 150                 155                 160 


Thr Leu Asn Asn Val Lys Ser Cys Val Ala Lys Ser Asp Ser Pro Val 
                165                 170                 175     


Ser Glu Leu Trp Tyr His Asn Leu Asn Val Asn Asn Cys Lys Thr Leu 
            180                 185                 190         


Phe Glu Phe Pro Ser Gln Ser Gln Ile His Gln Tyr 
        195                 200                 


<210>  27
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 46

<400>  27

Met Ala His His His His His His Val Gly Thr Asn Thr Gly Gly Val 
1               5                   10                  15      


Leu Val Ile Thr Asp Thr Ile Ile Val Lys Ser Gly Gln Thr Tyr Asp 
            20                  25                  30          


Gly Lys Gly Ile Lys Ile Ile Ala Gln Gly Met Gly Asp Gly Ser Gln 
        35                  40                  45              


Ser Glu Asn Gln Lys Pro Ile Phe Lys Leu Glu Lys Gly Ala Asn Leu 
    50                  55                  60                  


Lys Asn Val Ile Ile Gly Ala Pro Gly Cys Asp Gly Ile His Cys Tyr 
65                  70                  75                  80  


Gly Asp Asn Val Val Glu Asn Val Val Trp Glu Asp Val Gly Ala Asp 
                85                  90                  95      


Ala Leu Thr Val Lys Ser Glu Gly Val Val Glu Val Ile Lys Gly Asn 
            100                 105                 110         


Ala Lys His Ala Ala Asp Lys Val Phe Gln Leu Asn Ala Pro Cys Thr 
        115                 120                 125             


Phe Lys Val Lys Asn Phe Asp Ala Glu Asp Ile Gly Lys Leu Val Arg 
    130                 135                 140                 


Gln Asn Gly Asn Thr Thr Phe Lys Val Val Ile Tyr Leu Glu Lys Val 
145                 150                 155                 160 


Asn Leu Lys His Val Lys Ser Cys Val Ala Lys Ser Asp Ser Pro Val 
                165                 170                 175     


Ser Glu Leu Trp Tyr His Asn Leu Asp Val Glu Asp Cys Lys Thr Leu 
            180                 185                 190         


Phe Glu Phe Pro Ser Gln Ser Gln Ile His Gln Tyr 
        195                 200                 


<210>  28
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 47

<400>  28

Met Ala His His His His His His Val Gly Thr Asn Thr Gly Gly Val 
1               5                   10                  15      


Leu Val Ile Thr Asp Thr Ile Ile Val Lys Ser Gly Gln Thr Tyr Asp 
            20                  25                  30          


Gly Lys Gly Ile Lys Ile Ile Ala Gln Gly Met Gly Asp Gly Ser Gln 
        35                  40                  45              


Ser Glu Asn Gln Lys Pro Ile Phe Lys Leu Glu Lys Gly Ala Asn Leu 
    50                  55                  60                  


Lys Asn Val Ile Ile Gly Ala Pro Gly Cys Asp Gly Ile His Cys Tyr 
65                  70                  75                  80  


Gly Asp Asn Val Val Glu Asn Val Val Trp Glu Asp Val Gly Ala Asp 
                85                  90                  95      


Ala Leu Thr Val Lys Ser Glu Gly Val Val Glu Val Ile Gly Gly Asp 
            100                 105                 110         


Ala Glu Asp Ala Ala Asp Lys Val Phe Gln Leu Asn Ala Pro Cys Thr 
        115                 120                 125             


Phe Lys Val Lys Lys Phe Asn Ala Lys His Ile Gly Lys Leu Val Arg 
    130                 135                 140                 


Gln Asn Gly Asn Thr Thr Phe Lys Val Val Ile Tyr Leu Glu Asp Val 
145                 150                 155                 160 


Asp Leu Glu Asp Val Lys Ser Cys Val Ala Lys Ser Asp Ser Pro Val 
                165                 170                 175     


Ser Glu Leu Trp Tyr His Lys Leu Asn Val Lys His Cys Lys Thr Leu 
            180                 185                 190         


Phe Glu Phe Pro Ser Gln Ser Gln Ile His Gln Tyr 
        195                 200                 


<210>  29
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 48

<400>  29

Ser Gly Leu Gln Gly Met Asp Val Val His Gly Thr Ala Thr Met Gln 
1               5                   10                  15      


Val Asp Gly Asn Lys Thr Ile Ile Arg Asn Ser Val Asp Ala Ile Ile 
            20                  25                  30          


Asn Trp Lys Gln Phe Asn Ile Asp Gln Asn Glu Met Val Gln Phe Leu 
        35                  40                  45              


Gln Glu Asn Asn Asn Ser Ala Val Phe Asn Arg Val Thr Ser Asn Gln 
    50                  55                  60                  


Ile Ser Gln Leu Lys Gly Ile Leu Asp Ser Asn Gly Gln Val Phe Leu 
65                  70                  75                  80  


Ile Asn Pro Asn Gly Ile Thr Ile Gly Lys Asp Ala Ile Ile Asn Thr 
                85                  90                  95      


Asn Gly Phe Thr Ala Ser Thr Leu Asp Ile Ser Asn Glu Asn Ile Lys 
            100                 105                 110         


Ala Arg Asn Phe Thr Phe Glu Gln Thr Lys Asp Lys Ala Leu Ala Glu 
        115                 120                 125             


Ile Val Asn His Gly Leu Ile Thr Val Gly Lys Asp Gly Ser Val Asn 
    130                 135                 140                 


Leu Ile Gly Gly Lys Val Lys Asn Glu Gly Val Ile Ser Val Asn Gly 
145                 150                 155                 160 


Gly Ser Ile Ser Leu Leu Ala Gly Gln Lys Ile Thr Ile Ser Asp Ile 
                165                 170                 175     


Ile Asn Pro Thr Ile Thr Tyr Ser Ile Ala Ala Pro Glu Asn Glu Ala 
            180                 185                 190         


Val Asn Leu Gly Asp Ile Phe Ala Lys Gly Gly Asn Ile Asn Val Arg 
        195                 200                 205             


Ala Ala Thr Ile Arg Asn Gln Gly Lys Leu Ser Ala Asp Ser Val Ser 
    210                 215                 220                 


Lys Asp Gly Ser Gly Asn Ile Val Leu Ser Ala Lys Glu Gly Glu Ala 
225                 230                 235                 240 


Glu Ile Gly Gly Val Ile Ser Ala Gln Asn Gln Gln Ala Lys Gly Gly 
                245                 250                 255     


Lys Leu Met Ile Thr Gly Asp Lys Val Thr Leu Lys Thr Gly Ala Val 
            260                 265                 270         


Ile Asp Leu Ser Gly Lys Glu Gly Gly Glu Thr Tyr Leu Gly Gly Asp 
        275                 280                 285             


Glu Arg Gly Glu Gly Lys Asn Gly Ile Gln Leu Ala Lys Lys Thr Ser 
    290                 295                 300                 


Leu Glu Lys Gly Ser Thr Ile Asn Val Ser Gly Lys Glu Lys Gly Gly 
305                 310                 315                 320 


Arg Ala Ile Val Trp Gly Asp Ile Ala Leu Ile Asp Gly Asn Ile Asn 
                325                 330                 335     


Ala Gln Gly Ser Gly Asp Ile Ala Lys Thr Gly Gly Phe Val Glu Thr 
            340                 345                 350         


Ser Gly His Asp Leu Phe Ile Lys Asp Asn Ala Ile Val Asp Ala Lys 
        355                 360                 365             


Glu Trp Leu Leu Asp 
    370             


<210>  30
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 48

<400>  30

Met Ala His His His His His His Val Gly Thr Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Lys Glu Ile Val Asn His Gly Leu Ile Thr Val Gly Asp Gly 
            20                  25                  30          


Ser Val Asn Leu Ile Gly Gly Lys Val Lys Asn Glu Gly Val Ile Ser 
        35                  40                  45              


Val Asn Gly Gly Ser Ile Ser Leu Leu Ala Gly Glu Ala Val Asn Leu 
    50                  55                  60                  


Gly Asp Ile Phe Ala Lys Gly Gly Asn Ile Asn Val Arg Ala Ala Thr 
65                  70                  75                  80  


Ile Arg Asn Gln Gly Lys Leu Ser Ala Gly Lys Gly Asn Ile Val Leu 
                85                  90                  95      


Ser Ala Gly Glu 
            100 


<210>  31
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 49

<400>  31

Asp Pro Cys Ser Val Thr Glu Tyr Ser Gly Leu Ala Thr Ala Val Ser 
1               5                   10                  15      


Ser Cys Lys Asn Ile Val Leu Asn Gly Phe Gln Val Pro Thr Gly Lys 
            20                  25                  30          


Gln Leu Asp Leu Ser Ser Leu Gln Asn Asp Ser Thr Val Thr Phe Lys 
        35                  40                  45              


Gly Thr Thr Thr Phe Ala Thr Thr Ala Asp Asn Asp Phe Asn Pro Ile 
    50                  55                  60                  


Val Ile Ser Gly Ser Asn Ile Thr Ile Thr Gly Ala Ser Gly His Val 
65                  70                  75                  80  


Ile Asp Gly Asn Gly Gln Ala Tyr Trp Asp Gly Lys Gly Ser Asn Ser 
                85                  90                  95      


Asn Ser Asn Gln Lys Pro Asp His Phe Ile Val Val Gln Lys Thr Thr 
            100                 105                 110         


Gly Asn Ser Lys Ile Thr Asn Leu Asn Ile Gln Asn Trp Pro Val His 
        115                 120                 125             


Cys Phe Asp Ile Thr Gly Ser Ser Gln Leu Thr Ile Ser Gly Leu Ile 
    130                 135                 140                 


Leu Asp Asn Arg Ala Gly Asp Lys Pro Asn Ala Lys Ser Gly Ser Leu 
145                 150                 155                 160 


Pro Ala Ala His Asn Thr Asp Gly Phe Asp Ile Ser Ser Ser Asp His 
                165                 170                 175     


Val Thr Leu Asp Asn Asn His Val Tyr Asn Gln Asp Asp Cys Val Ala 
            180                 185                 190         


Val Thr Ser Gly Thr Asn Ile Val Val Ser Asn Met Tyr Cys Ser Gly 
        195                 200                 205             


Gly His Gly Leu Ser Ile Gly Ser Val Gly Gly Lys Ser Asp Asn Val 
    210                 215                 220                 


Val Asp Gly Val Gln Phe Leu Ser Ser Gln Val Val Asn Ser Gln Asn 
225                 230                 235                 240 


Gly Cys Arg Ile Lys Ser Asn Ser Gly Ala Thr Gly Thr Ile Asn Asn 
                245                 250                 255     


Val Thr Tyr Gln Asn Ile Ala Leu Thr Asn Ile Ser Thr Tyr Gly Val 
            260                 265                 270         


Asp Val Gln Gln Asp Tyr Leu Asn Gly Gly Pro Thr Gly Lys Pro Thr 
        275                 280                 285             


Asn Gly Val Lys Ile Ser Asn Ile Lys Phe Ile Lys Val Thr Gly Thr 
    290                 295                 300                 


Val Ala Ser Ser Ala Gln Asp Trp Phe Ile Leu Cys Gly Asp Gly Ser 
305                 310                 315                 320 


Cys Ser Gly Phe Thr Phe Ser Gly Asn Ala Ile Thr Gly Gly Gly Lys 
                325                 330                 335     


Thr Ser Ser Cys Asn Tyr Pro Thr Asn Thr Cys Pro Ser 
            340                 345                 


<210>  32
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 49

<400>  32

Met Ala His His His His His His Val Gly Thr Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Asp Gly Phe Asp Ile Ser Ser Ser Asp His Val Thr Leu Asp 
            20                  25                  30          


Asn Asn His Val Tyr Asn Gln Asp Asp Cys Val Ala Val Thr Ser Gly 
        35                  40                  45              


Thr Asn Ile Val Val Ser Asn Met Tyr Cys Ser Gly Gly His Gly Leu 
    50                  55                  60                  


Ser Ile Gly Ser Val Gly Gly Lys Ser Asp Asn Val Val Asp Gly Val 
65                  70                  75                  80  


Gln Phe Leu Ser Ser Gln Val Val Asn Ser Gln Asn Gly Cys Arg Ile 
                85                  90                  95      


Lys Ser Asn Ser Gly Ala Thr Gly Thr Ile Asn Asn Val Thr Tyr Gln 
            100                 105                 110         


Asn Ile Ala Leu Thr Asn Ile Ser Arg 
        115                 120     


<210>  33
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Claims

<400>  33

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Lys Asp Ile Arg 
1               5                   10                  15      


Thr Glu Glu Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Cys Val 
        35                  40                  45              


Glu Thr Val Val Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu 
    50                  55                  60                  


Tyr Gly Gly Lys Gly Phe Trp Asp Asn Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Ala Gly Gly Gly Gly Gly Asn Ser Ala Lys Asp Ile Arg Thr Glu 
                85                  90                  95      


Glu Arg Ala Arg Val Gln Leu Gly Asn Val Val Thr Ala Ala Ala Leu 
            100                 105                 110         


His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val Glu Thr 
        115                 120                 125             


Val Val Gly Lys Gly Glu Ser Arg Val Leu Ile Gly Asn Glu Tyr Gly 
    130                 135                 140                 


Gly Lys Gly Phe Trp Asp Asn 
145                 150     


<210>  34
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  claims

<400>  34

Met Lys Ile Asp Ala Ile Val Gly Arg Asn Ser Ala Lys Tyr Ile Asp 
1               5                   10                  15      


Thr Glu Asp Arg Ala Glu Val Gln Leu Gly Asn Val Val Thr Ala Ala 
            20                  25                  30          


Ala Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val 
        35                  40                  45              


Glu Lys Val Asn Gly Lys His Glu Ser Arg Val Arg Leu Ile Gly Asn 
    50                  55                  60                  


Glu Tyr Gly Gly Lys Gly Phe Trp Asp Asn Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ala Ala Gly Gly Gly Gly Gly Asn Ser Ala Lys Tyr Ile Asp Thr 
                85                  90                  95      


Glu Asp Arg Ala Glu Val Gln Leu Gly Asn Val Val Thr Ala Ala Ala 
            100                 105                 110         


Leu His Gly Gly Ile Arg Ile Ser Asp Gln Thr Thr Asn Ser Val Glu 
        115                 120                 125             


Lys Val Asn Gly Lys His Glu Ser Arg Val Leu Ile Gly Asn Glu Tyr 
    130                 135                 140                 


Gly Gly Lys Gly Phe Trp Asp Asn 
145                 150         


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 15

<400>  35

Gly Lys Met Gly Gly Arg Phe Tyr Phe Asp Tyr 
1               5                   10      


