
                                SEQUENCE LISTING

<110> Northeastern University
      University of York
      Wanunu, Meni
      Antson, Alfred
      Greive, Sandra
      Cressiot, Benjamin

<120> LIPID-FREE ANCHORING OF THERMOPHILIC
  BACTERIOPHAGE G20C PORTAL ADAPTER INTO SOLID-STATE NANOPORES
  

<130> 5200.2223002

<140> PCT/US2019/033006   
<141> 2019-05-17  

<150> 62/673,118          
<151> 2018-05-17  

<160> 41

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 448
<212> PRT
<213> Thermus Thermophilus Bacteriophage G20C

<400> 1
Met Ala Lys Arg Gly Arg Lys Pro Lys Glu Leu Val Pro Gly Pro Gly
 1               5                  10                  15      
Ser Ile Asp Pro Ser Asp Val Pro Lys Leu Glu Gly Ala Ser Val Pro
            20                  25                  30          
Val Met Ser Thr Ser Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu
        35                  40                  45              
Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser
    50                  55                  60                  
Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg
65                  70                  75                  80  
Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile
                85                  90                  95      
Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser
            100                 105                 110         
Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala
        115                 120                 125             
Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala
    130                 135                 140                 
Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn
145                 150                 155                 160 
Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys
                165                 170                 175     
Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu
            180                 185                 190         
Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp Asp Gly Ser
        195                 200                 205             
Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala
    210                 215                 220                 
Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met
225                 230                 235                 240 
Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr
                245                 250                 255     
Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys
            260                 265                 270         
Pro Arg His Gly Ile Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val
        275                 280                 285             
Asp Leu Lys Ser Ala Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His
    290                 295                 300                 
Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln
305                 310                 315                 320 
Leu Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu
                325                 330                 335     
Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val
            340                 345                 350         
Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala
        355                 360                 365             
Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe
    370                 375                 380                 
Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp
385                 390                 395                 400 
Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro
                405                 410                 415     
Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala
            420                 425                 430         
Val Arg Gln Pro Ala Asp Ser Arg Tyr Leu Tyr Thr Arg Arg Arg Arg
        435                 440                 445             


<210> 2
<211> 1347
<212> DNA
<213> Thermus Thermophilus Bacteriophage G20C

<400> 2
atggctaagc gaggacgtaa acccaaagag ctggtccccg gacctggctc cattgaccca 60
tctgacgttc ccaagctcga gggcgcctcc gtgccggtga tgtccaccag ttacgacgtg 120
gtggtggacc gggagtttga cgagctactg cagggcaagg acggcttgct cgtctaccac 180
aagatgctct cggacggcac ggttaagaac gccctcaact acatcttcgg acgcatccgc 240
tcggcgaagt ggtacgtaga gcccgcctct accgacccgg aagacatcgc catcgccgcc 300
ttcatccacg cccagttagg catagacgac gcttcggtgg gcaagtatcc ctttggccgc 360
cttttcgcca tctacgaaaa cgcctacata tacggcatgg ccgccgggga aatcgtacta 420
acccttggcg cggacggcaa gctcatcctt gacaaaatcg tccctatcca ccctttcaac 480
attgacgagg tgctttacga cgaggaaggc ggtccaaagg cgctaaagct aagcggagag 540
gtgaagggcg gaagccagtt tgtgagcggg ttggagattc ctatatggaa gaccgtggtc 600
ttcctgcaca acgacgacgg ctccttcacc ggacagagcg ccctcagagc cgccgtgccg 660
cattggctag ccaaacgagc cctcattctc ctcatcaacc acgggttgga gcgcttcatg 720
attggcgtgc ccaccctcac catccccaag agcgtgcgtc agggaaccaa gcaatgggag 780
gccgccaagg aaatcgtcaa gaactttgtt caaaaaccac ggcatggtat aatactgcct 840
gacgactgga agtttgacac ggtagacctg aagtcggcca tgcccgacgc cattccctac 900
ctgacctacc acgacgcggg catcgctagg gcgcttggca tagacttcaa caccgttcaa 960
ctaaacatgg gggtacaggc gataaacatc ggcgagttcg taagcctgac ccagcagacc 1020
atcatttcgc tccagcggga gttcgctagc gcggtcaacc tctacctcat ccccaagcta 1080
gtgcttccca actggccgag cgctactcgc tttcctaggc tcacctttga gatggaggag 1140
cgcaacgact tctccgccgc ggccaacctt atgggcatgc tcatcaacgc ggttaaggac 1200
tccgaagaca ttcccaccga gctcaaggcg ctaatagacg ctctgcctag caagatgcgc 1260
cgggcgcttg gcgtggtgga cgaggtgagg gaagcggtac gccaacccgc cgattcccgc 1320
tacctgtaca cgcgaaggag gaggtag                                     1347

<210> 3
<211> 446
<212> PRT
<213> Thermus Thermophilus Bacteriophage G20C

<400> 3
Met Ala Lys Arg Gly Arg Lys Pro Lys Glu Leu Val Pro Gly Pro Gly
 1               5                  10                  15      
Ser Ile Asp Pro Ser Asp Val Pro Lys Leu Glu Gly Ala Ser Val Pro
            20                  25                  30          
Val Met Ser Thr Ser Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu
        35                  40                  45              
Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser
    50                  55                  60                  
Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg
65                  70                  75                  80  
Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile
                85                  90                  95      
Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser
            100                 105                 110         
Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala
        115                 120                 125             
Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala
    130                 135                 140                 
Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn
145                 150                 155                 160 
Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys
                165                 170                 175     
Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu
            180                 185                 190         
Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp Asp Gly Ser
        195                 200                 205             
Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala
    210                 215                 220                 
Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met
225                 230                 235                 240 
Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr
                245                 250                 255     
Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys
            260                 265                 270         
Pro Arg His Gly Ile Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val
        275                 280                 285             
Asp Leu Lys Ser Ala Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His
    290                 295                 300                 
Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln
305                 310                 315                 320 
Leu Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu
                325                 330                 335     
Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val
            340                 345                 350         
Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala
        355                 360                 365             
Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe
    370                 375                 380                 
Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp
385                 390                 395                 400 
Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro
                405                 410                 415     
Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala
            420                 425                 430         
Val Arg Gln Pro Ala Asp Leu Glu His His His His His His
        435                 440                 445     


<210> 4
<211> 1341
<212> DNA
<213> Artificial Sequence

<220> 
<223> Thermus Thermophilus Bacteriophage G20C and
      Affinity Tag; WT 1-438 C-term

<400> 4
atggctaagc gaggacgtaa acccaaagag ctggtccccg gacctggctc cattgaccca 60
tctgacgttc ccaagctcga gggcgcctcc gtgccggtga tgtccaccag ttacgacgtg 120
gtggtggacc gggagtttga cgagctactg cagggcaagg acggcttgct cgtctaccac 180
aagatgctct cggacggcac ggttaagaac gccctcaact acatcttcgg acgcatccgc 240
tcggcgaagt ggtacgtaga gcccgcctct accgacccgg aagacatcgc catcgccgcc 300
ttcatccacg cccagttagg catagacgac gcttcggtgg gcaagtatcc ctttggccgc 360
cttttcgcca tctacgaaaa cgcctacata tacggcatgg ccgccgggga aatcgtacta 420
acccttggcg cggacggcaa gctcatcctt gacaaaatcg tccctatcca ccctttcaac 480
attgacgagg tgctttacga cgaggaaggc ggtccaaagg cgctaaagct aagcggagag 540
gtgaagggcg gaagccagtt tgtgagcggg ttggagattc ctatatggaa gaccgtggtc 600
ttcctgcaca acgacgacgg ctccttcacc ggacagagcg ccctcagagc cgccgtgccg 660
cattggctag ccaaacgagc cctcattctc ctcatcaacc acgggttgga gcgcttcatg 720
attggcgtgc ccaccctcac catccccaag agcgtgcgtc agggaaccaa gcaatgggag 780
gccgccaagg aaatcgtcaa gaactttgtt caaaaaccac ggcatggtat aatactgcct 840
gacgactgga agtttgacac ggtagacctg aagtcggcca tgcccgacgc cattccctac 900
ctgacctacc acgacgcggg catcgctagg gcgcttggca tagacttcaa caccgttcaa 960
ctaaacatgg gggtacaggc gataaacatc ggcgagttcg taagcctgac ccagcagacc 1020
atcatttcgc tccagcggga gttcgctagc gcggtcaacc tctacctcat ccccaagcta 1080
gtgcttccca actggccgag cgctactcgc tttcctaggc tcacctttga gatggaggag 1140
cgcaacgact tctccgccgc ggccaacctt atgggcatgc tcatcaacgc ggttaaggac 1200
tccgaagaca ttcccaccga gctcaaggcg ctaatagacg ctctgcctag caagatgcgc 1260
cgggcgcttg gcgtggtgga cgaggtgagg gaagcggtac gccaacccgc cgatctcgag 1320
caccaccacc accaccacta g                                           1341

<210> 5
<211> 441
<212> PRT
<213> Thermus Thermophilus Bacteriophage G20C

<400> 5
Gly Pro Ala Met Ala Lys Arg Gly Arg Lys Pro Lys Glu Leu Val Pro
 1               5                  10                  15      
Gly Pro Gly Ser Ile Asp Pro Ser Asp Val Pro Lys Leu Glu Gly Ala
            20                  25                  30          
Ser Val Pro Val Met Ser Thr Ser Tyr Asp Val Val Val Asp Arg Glu
        35                  40                  45              
Phe Asp Glu Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys
    50                  55                  60                  
Met Leu Ser Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly
65                  70                  75                  80  
Arg Ile Arg Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro
                85                  90                  95      
Glu Asp Ile Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp
            100                 105                 110         
Asp Ala Ser Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr
        115                 120                 125             
Glu Asn Ala Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr
    130                 135                 140                 
Leu Gly Ala Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His
145                 150                 155                 160 
Pro Phe Asn Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys
                165                 170                 175     
Ala Leu Lys Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser
            180                 185                 190         
Gly Leu Glu Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp
        195                 200                 205             
Asp Gly Ser Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His
    210                 215                 220                 
Trp Leu Ala Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu
225                 230                 235                 240 
Arg Phe Met Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg
                245                 250                 255     
Gln Gly Thr Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe
            260                 265                 270         
Val Gln Lys Pro Arg His Gly Ile Ile Leu Pro Asp Asp Trp Lys Phe
        275                 280                 285             
Asp Thr Val Asp Leu Lys Ser Ala Met Pro Asp Ala Ile Pro Tyr Leu
    290                 295                 300                 
Thr Tyr His Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn
305                 310                 315                 320 
Thr Val Gln Leu Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe
                325                 330                 335     
Val Ser Leu Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala
            340                 345                 350         
Ser Ala Val Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp
        355                 360                 365             
Pro Ser Ala Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg
    370                 375                 380                 
Asn Asp Phe Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala
385                 390                 395                 400 
Val Lys Asp Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp
                405                 410                 415     
Ala Leu Pro Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val
            420                 425                 430         
Arg Glu Ala Val Arg Gln Pro Ala Asp
        435                 440     


<210> 6
<211> 1383
<212> DNA
<213> Artificial Sequence

<220> 
<223> Thermus Thermophilus Bacteriophage G20C and
      Affinity Tag; WT 1-438 3C prot

<400> 6
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaatgg ctaagcgagg acgtaaaccc aaagagctgg tccccggacc tggctccatt 120
gacccatctg acgttcccaa gctcgagggc gcctccgtgc cggtgatgtc caccagttac 180
gacgtggtgg tggaccggga gtttgacgag ctactgcagg gcaaggacgg cttgctcgtc 240
taccacaaga tgctctcgga cggcacggtt aagaacgccc tcaactacat cttcggacgc 300
atccgctcgg cgaagtggta cgtagagccc gcctctaccg acccggaaga catcgccatc 360
gccgccttca tccacgccca gttaggcata gacgacgctt cggtgggcaa gtatcccttt 420
ggccgccttt tcgccatcta cgaaaacgcc tacatatacg gcatggccgc cggggaaatc 480
gtactaaccc ttggcgcgga cggcaagctc atccttgaca aaatcgtccc tatccaccct 540
ttcaacattg acgaggtgct ttacgacgag gaaggcggtc caaaggcgct aaagctaagc 600
ggagaggtga agggcggaag ccagtttgtg agcgggttgg agattcctat atggaagacc 660
gtggtcttcc tgcacaacga cgacggctcc ttcaccggac agagcgccct cagagccgcc 720
gtgccgcatt ggctagccaa acgagccctc attctcctca tcaaccacgg gttggagcgc 780
ttcatgattg gcgtgcccac cctcaccatc cccaagagcg tgcgtcaggg aaccaagcaa 840
tgggaggccg ccaaggaaat cgtcaagaac tttgttcaaa aaccacggca tggtataata 900
ctgcctgacg actggaagtt tgacacggta gacctgaagt cggccatgcc cgacgccatt 960
ccctacctga cctaccacga cgcgggcatc gctagggcgc ttggcataga cttcaacacc 1020
gttcaactaa acatgggggt acaggcgata aacatcggcg agttcgtaag cctgacccag 1080
cagaccatca tttcgctcca gcgggagttc gctagcgcgg tcaacctcta cctcatcccc 1140
aagctagtgc ttcccaactg gccgagcgct actcgctttc ctaggctcac ctttgagatg 1200
gaggagcgca acgacttctc cgccgcggcc aaccttatgg gcatgctcat caacgcggtt 1260
aaggactccg aagacattcc caccgagctc aaggcgctaa tagacgctct gcctagcaag 1320
atgcgccggg cgcttggcgt ggtggacgag gtgagggaag cggtacgcca acccgccgat 1380
taa                                                               1383

<210> 7
<211> 417
<212> PRT
<213> Thermus Thermophilus Bacteriophage G20C

<400> 7
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 8
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> Thermus Thermophilus Bacteriophage G20C and
      Affinity Tag; WT Nanopore

<400> 8
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atgggggtac aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 9
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> L230E

<400> 9
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Glu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 10
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> L230E

<400> 10
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tgagctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atgggggtac aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 11
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> 49C

<220> 
<221> VARIANT        
<222> 251
<223> Xaa = Any Amino Acid

<400> 11
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Cys Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Xaa Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 12
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> 49C

<220> 
<221> misc_feature   
<222> 810
<223> n = A,T,C or G

<400> 12
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagtg tctgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaan ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atgggggtac aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 13
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> 40E

<220> 
<221> VARIANT        
<222> 251
<223> Xaa = Any Amino Acid

<400> 13
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Glu Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Xaa Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 14
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> 40E

<220> 
<221> misc_feature   
<222> 810
<223> n = A,T,C or G

<400> 14
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgaggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaan ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atgggggtac aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 15
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> G

<400> 15
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Gly
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 16
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> G

<400> 16
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atggggggac aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 17
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> M

<400> 17
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Met
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 18
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> M

<400> 18
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atggggatgc aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 19
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> K

<400> 19
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val
    290                 295                 300                 
Gln Ala Lys Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 20
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> K

<400> 20
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atgggggtac aggcgaagaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 21
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> CGG

<400> 21
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Cys Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Gly
    290                 295                 300                 
Gln Ala Gly Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 22
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> CGG

<400> 22
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagtg tctgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atggggggac aggcgggaaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggtc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 23
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Loop2GG

<400> 23
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Gly
    290                 295                 300                 
Gly Gly Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile Ile
305                 310                 315                 320 
Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu Tyr Leu Ile Pro
                325                 330                 335     
Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg Leu
            340                 345                 350         
Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn Leu
        355                 360                 365             
Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro Thr
    370                 375                 380                 
Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg Ala
385                 390                 395                 400 
Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala Asp
                405                 410                 415     


<210> 24
<211> 1308
<212> DNA
<213> Artificial Sequence

<220> 
<223> Loop2GG

<400> 24
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagct actgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctgacgac 840
tggaagtttg acacggtaga cctgaagtcg gccatgcccg acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atggggggag gcggtaacat cggcgagttc gtaagcctga cccagcagac catcatttcg 1020
ctccagcggg agttcgctag cgcggtcaac ctctacctca tccccaagct agtgcttccc 1080
aactggccga gcgctactcg ctttcctagg ctcacctttg agatggagga gcgcaacgac 1140
ttctccgccg cggccaacct tatgggcatg ctcatcaacg cggttaagga ctccgaagac 1200
attcccaccg agctcaaggc gctaatagac gctctgccta gcaagatgcg ccgggcgctt 1260
ggcgtggtgg acgaggtgag ggaagcggta cgccaacccg ccgattaa              1308

<210> 25
<211> 410
<212> PRT
<213> Artificial Sequence

<220> 
<223> 49CLoop3G

<400> 25
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Cys Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Gly Ile Gly Glu
    290                 295                 300                 
Phe Val Ser Leu Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe
305                 310                 315                 320 
Ala Ser Ala Val Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn
                325                 330                 335     
Trp Pro Ser Ala Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu
            340                 345                 350         
Arg Asn Asp Phe Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn
        355                 360                 365             
Ala Val Lys Asp Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile
    370                 375                 380                 
Asp Ala Leu Pro Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu
385                 390                 395                 400 
Val Arg Glu Ala Val Arg Gln Pro Ala Asp
                405                 410 


<210> 26
<211> 1269
<212> DNA
<213> Artificial Sequence

<220> 
<223> 49CLoop3G

<220> 
<221> misc_feature   
<222> 1266
<223> n = A,T,C or G

<400> 26
catcatcaca gcagcggcct ggaagttctg ttccagggac cagcaaagct cgagggcgcc 60
tccgtgccgg tgatgtccac cagttacgac gtggtggtgg accgggagtt tgacgagtgt 120
ctgcagggca aggacggctt gctcgtctac cacaagatgc tctcggacgg cacggttaag 180
aacgccctca actacatctt cggacgcatc cgctcggcga agtggtacgt agagcccgcc 240
tctaccgacc cggaagacat cgccatcgcc gccttcatcc acgcccagtt aggcatagac 300
gacgcttcgg tgggcaagta tccctttggc cgccttttcg ccatctacga aaacgcctac 360
atatacggca tggccgccgg ggaaatcgta ctaacccttg gcgcggacgg caagctcatc 420
cttgacaaaa tcgtccctat ccaccctttc aacattgacg aggtgcttta cgacgaggaa 480
ggcggtccaa aggcgctaaa gctaagcgga gaggtgaagg gcggaagcca gtttgtgagc 540
gggttggaga ttcctatatg gaagaccgtg gtcttcctgc acaacgacga cggctccttc 600
accggacaga gcgccctcag agccgccgtg ccgcattggc tagccaaacg agccctcatt 660
ctcctcatca accacgggtt ggagcgcttc atgattggcg tgcccaccct caccatcccc 720
aagagcgtgc gtcagggaac caagcaatgg gaggccgcca aggaaatcgt caagaacttt 780
gttcaaaaac cacggcatgg tataatactg cctgacgact ggaagtttga cacggtagac 840
ctgaagtcgg ccatgcccga cgccattccc tacctgacct accacgacgc gggcatcgct 900
agggcgcttg gcatagactt caacaccgtt caactaggta tcggcgagtt cgtaagcctg 960
acccagcaga ccatcatttc gctccagcgg gagttcgcta gcgcggtcaa cctctacctc 1020
atccccaagc tagtgcttcc caactggccg agcgctactc gctttcctag gctcaccttt 1080
gagatggagg agcgcaacga cttctccgcc gcggccaacc ttatgggcat gctcatcaac 1140
gcggttaagg actccgaaga cattcccacc gagctcaagg cgctaataga cgctctgcct 1200
agcaagatgc gccgggcgct tggcgtggtg gacgaggtga gggaagcggt acgccaaccc 1260
gccgantaa                                                         1269

<210> 27
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD/N

<400> 27
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Cys Leu Gln Gly Lys
            20                  25                  30          
Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys
        35                  40                  45              
Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr
    50                  55                  60                  
Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe
65                  70                  75                  80  
Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro
                85                  90                  95      
Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met
            100                 105                 110         
Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile
        115                 120                 125             
Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu
    130                 135                 140                 
Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val
145                 150                 155                 160 
Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys
                165                 170                 175     
Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser
            180                 185                 190         
Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile
        195                 200                 205             
Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr
    210                 215                 220                 
Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala
225                 230                 235                 240 
Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile
                245                 250                 255     
Ile Leu Pro Asn Asp Trp Lys Phe Asn Thr Val Asn Leu Lys Ser Ala
            260                 265                 270         
Met Pro Asn Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala
        275                 280                 285             
Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val
    290                 295                 300                 
Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile
305                 310                 315                 320 
Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Ala Asn Leu Tyr Leu Ile
                325                 330                 335     
Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg
            340                 345                 350         
Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn
        355                 360                 365             
Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro
    370                 375                 380                 
Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg
385                 390                 395                 400 
Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala
                405                 410                 415     
Asp
    


<210> 28
<211> 1311
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD/N

<400> 28
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgagtg tctgcagggc aaggacggct tgctcgtcta ccacaagatg 180
ctctcggacg gcacggttaa gaacgccctc aactacatct tcggacgcat ccgctcggcg 240
aagtggtacg tagagcccgc ctctaccgac ccggaagaca tcgccatcgc cgccttcatc 300
cacgcccagt taggcataga cgacgcttcg gtgggcaagt atccctttgg ccgccttttc 360
gccatctacg aaaacgccta catatacggc atggccgccg gggaaatcgt actaaccctt 420
ggcgcggacg gcaagctcat ccttgacaaa atcgtcccta tccacccttt caacattgac 480
gaggtgcttt acgacgagga aggcggtcca aaggcgctaa agctaagcgg agaggtgaag 540
ggcggaagcc agtttgtgag cgggttggag attcctatat ggaagaccgt ggtcttcctg 600
cacaacgacg acggctcctt caccggacag agcgccctca gagccgccgt gccgcattgg 660
ctagccaaac gagccctcat tctcctcatc aaccacgggt tggagcgctt catgattggc 720
gtgcccaccc tcaccatccc caagagcgtg cgtcagggaa ccaagcaatg ggaggccgcc 780
aaggaaatcg tcaagaactt tgttcaaaaa ccacggcatg gtataatact gcctaacgac 840
tggaagttta acacggtaaa cctgaagtcg gccatgccca acgccattcc ctacctgacc 900
taccacgacg cgggcatcgc tagggcgctt ggcatagact tcaacaccgt tcaactaaac 960
atgggggtac aggcgataaa catcggcgag ttcgtaagcc tgacccagca gaccatcatt 1020
tcgctccagc gggagttcgc tagcgcggcc aacctctacc tcatccccaa gctagtgctt 1080
cccaactggc cgagcgctac tcgctttcct aggctcacct ttgagatgga ggagcgcaac 1140
gacttctccg ccgcggccaa ccttatgggc atgctcatca acgcggttaa ggactccgaa 1200
gacattccca ccgagctcaa ggcgctaata gacgctctgc ctagcaagat gcgccgggcg 1260
cttggcgtgg tggacgaggt gagggaagcg gtacgccaac ccgccgatta a          1311

<210> 29
<211> 424
<212> PRT
<213> Artificial Sequence

<220> 
<223> SIN1

<400> 29
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Gly Thr Pro Gly Ser
            20                  25                  30          
Arg Gly Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys Met
        35                  40                  45              
Leu Ser Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly Arg
    50                  55                  60                  
Ile Arg Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro Glu
65                  70                  75                  80  
Asp Ile Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp Asp
                85                  90                  95      
Ala Ser Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr Glu
            100                 105                 110         
Asn Ala Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr Leu
        115                 120                 125             
Gly Ala Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His Pro
    130                 135                 140                 
Phe Asn Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys Ala
145                 150                 155                 160 
Leu Lys Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser Gly
                165                 170                 175     
Leu Glu Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp Asp
            180                 185                 190         
Gly Ser Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His Trp
        195                 200                 205             
Leu Ala Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu Arg
    210                 215                 220                 
Phe Met Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg Gln
225                 230                 235                 240 
Gly Thr Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe Val
                245                 250                 255     
Gln Lys Pro Arg His Gly Ile Ile Leu Pro Asn Asp Trp Lys Phe Asn
            260                 265                 270         
Thr Val Asn Leu Lys Ser Ala Met Pro Asn Ala Ile Pro Tyr Leu Thr
        275                 280                 285             
Tyr His Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn Thr
    290                 295                 300                 
Val Gln Leu Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe Val
305                 310                 315                 320 
Ser Leu Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala Ser
                325                 330                 335     
Ala Val Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp Pro
            340                 345                 350         
Ser Ala Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg Asn
        355                 360                 365             
Asp Phe Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala Val
    370                 375                 380                 
Lys Asp Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp Ala
385                 390                 395                 400 
Leu Pro Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val Arg
                405                 410                 415     
Glu Ala Val Arg Gln Pro Ala Asp
            420                 


<210> 30
<211> 1332
<212> DNA
<213> Artificial Sequence

<220> 
<223> SIN1

<400> 30
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgaggg tacgccaggt tctcgcggcc tactgcaggg caaggacggc 180
ttgctcgtct accacaagat gctctcggac ggcacggtta agaacgccct caactacatc 240
ttcggacgca tccgctcggc gaagtggtac gtagagcccg cctctaccga cccggaagac 300
atcgccatcg ccgccttcat ccacgcccag ttaggcatag acgacgcttc ggtgggcaag 360
tatccctttg gccgcctttt cgccatctac gaaaacgcct acatatacgg catggccgcc 420
ggggaaatcg tactaaccct tggcgcggac ggcaagctca tccttgacaa aatcgtccct 480
atccaccctt tcaacattga cgaggtgctt tacgacgagg aaggcggtcc aaaggcgcta 540
aagctaagcg gagaggtgaa gggcggaagc cagtttgtga gcgggttgga gattcctata 600
tggaagaccg tggtcttcct gcacaacgac gacggctcct tcaccggaca gagcgccctc 660
agagccgccg tgccgcattg gctagccaaa cgagccctca ttctcctcat caaccacggg 720
ttggagcgct tcatgattgg cgtgcccacc ctcaccatcc ccaagagcgt gcgtcaggga 780
accaagcaat gggaggccgc caaggaaatc gtcaagaact ttgttcaaaa accacggcat 840
ggtataatac tgcctaacga ctggaagttt aacacggtaa acctgaagtc ggccatgccc 900
aacgccattc cctacctgac ctaccacgac gcgggcatcg ctagggcgct tggcatagac 960
ttcaacaccg ttcaactaaa catgggggta caggcgataa acatcggcga gttcgtaagc 1020
ctgacccagc agaccatcat ttcgctccag cgggagttcg ctagcgcggt caacctctac 1080
ctcatcccca agctagtgct tcccaactgg ccgagcgcta ctcgctttcc taggctcacc 1140
tttgagatgg aggagcgcaa cgacttctcc gccgcggcca accttatggg catgctcatc 1200
aacgcggtta aggactccga agacattccc accgagctca aggcgctaat agacgctctg 1260
cctagcaaga tgcgccgggc gcttggcgtg gtggacgagg tgagggaagc ggtacgccaa 1320
cccgccgatt aa                                                     1332

<210> 31
<211> 425
<212> PRT
<213> Artificial Sequence

<220> 
<223> SIN2

<400> 31
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Gly Arg Lys Leu Pro
            20                  25                  30          
Asp Ala Gly Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys
        35                  40                  45              
Met Leu Ser Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly
    50                  55                  60                  
Arg Ile Arg Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro
65                  70                  75                  80  
Glu Asp Ile Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp
                85                  90                  95      
Asp Ala Ser Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr
            100                 105                 110         
Glu Asn Ala Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr
        115                 120                 125             
Leu Gly Ala Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His
    130                 135                 140                 
Pro Phe Asn Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys
145                 150                 155                 160 
Ala Leu Lys Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser
                165                 170                 175     
Gly Leu Glu Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp
            180                 185                 190         
Asp Gly Ser Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His
        195                 200                 205             
Trp Leu Ala Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu
    210                 215                 220                 
Arg Phe Met Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg
225                 230                 235                 240 
Gln Gly Thr Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe
                245                 250                 255     
Val Gln Lys Pro Arg His Gly Ile Ile Leu Pro Asn Asp Trp Lys Phe
            260                 265                 270         
Asn Thr Val Asn Leu Lys Ser Ala Met Pro Asn Ala Ile Pro Tyr Leu
        275                 280                 285             
Thr Tyr His Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn
    290                 295                 300                 
Thr Val Gln Leu Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe
305                 310                 315                 320 
Val Ser Leu Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala
                325                 330                 335     
Ser Ala Val Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp
            340                 345                 350         
Pro Ser Ala Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg
        355                 360                 365             
Asn Asp Phe Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala
    370                 375                 380                 
Val Lys Asp Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp
385                 390                 395                 400 
Ala Leu Pro Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val
                405                 410                 415     
Arg Glu Ala Val Arg Gln Pro Ala Asp
            420                 425 


<210> 32
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> SIN2

<400> 32
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgaggg tcgtaaactg ccggatgcag gcctactgca gggcaaggac 180
ggcttgctcg tctaccacaa gatgctctcg gacggcacgg ttaagaacgc cctcaactac 240
atcttcggac gcatccgctc ggcgaagtgg tacgtagagc ccgcctctac cgacccggaa 300
gacatcgcca tcgccgcctt catccacgcc cagttaggca tagacgacgc ttcggtgggc 360
aagtatccct ttggccgcct tttcgccatc tacgaaaacg cctacatata cggcatggcc 420
gccggggaaa tcgtactaac ccttggcgcg gacggcaagc tcatccttga caaaatcgtc 480
cctatccacc ctttcaacat tgacgaggtg ctttacgacg aggaaggcgg tccaaaggcg 540
ctaaagctaa gcggagaggt gaagggcgga agccagtttg tgagcgggtt ggagattcct 600
atatggaaga ccgtggtctt cctgcacaac gacgacggct ccttcaccgg acagagcgcc 660
ctcagagccg ccgtgccgca ttggctagcc aaacgagccc tcattctcct catcaaccac 720
gggttggagc gcttcatgat tggcgtgccc accctcacca tccccaagag cgtgcgtcag 780
ggaaccaagc aatgggaggc cgccaaggaa atcgtcaaga actttgttca aaaaccacgg 840
catggtataa tactgcctaa cgactggaag tttaacacgg taaacctgaa gtcggccatg 900
cccaacgcca ttccctacct gacctaccac gacgcgggca tcgctagggc gcttggcata 960
gacttcaaca ccgttcaact aaacatgggg gtacaggcga taaacatcgg cgagttcgta 1020
agcctgaccc agcagaccat catttcgctc cagcgggagt tcgctagcgc ggtcaacctc 1080
tacctcatcc ccaagctagt gcttcccaac tggccgagcg ctactcgctt tcctaggctc 1140
acctttgaga tggaggagcg caacgacttc tccgccgcgg ccaaccttat gggcatgctc 1200
atcaacgcgg ttaaggactc cgaagacatt cccaccgagc tcaaggcgct aatagacgct 1260
ctgcctagca agatgcgccg ggcgcttggc gtggtggacg aggtgaggga agcggtacgc 1320
caacccgccg attaa                                                  1335

<210> 33
<211> 431
<212> PRT
<213> Artificial Sequence

<220> 
<223> SIN3

<400> 33
Gly Pro Ala Ser Ser Lys Lys Ser Gly Ser Tyr Ser Gly Ser Lys Gly
 1               5                  10                  15      
Ser Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser Tyr Asp
            20                  25                  30          
Val Val Val Asp Arg Glu Phe Asp Glu Cys Leu Gln Gly Lys Asp Gly
        35                  40                  45              
Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly Thr Val Lys Asn Ala
    50                  55                  60                  
Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala Lys Trp Tyr Val Glu
65                  70                  75                  80  
Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile Ala Ala Phe Ile His
                85                  90                  95      
Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly Lys Tyr Pro Phe Gly
            100                 105                 110         
Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile Tyr Gly Met Ala Ala
        115                 120                 125             
Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly Lys Leu Ile Leu Asp
    130                 135                 140                 
Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp Glu Val Leu Tyr Asp
145                 150                 155                 160 
Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser Gly Glu Val Lys Gly
                165                 170                 175     
Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro Ile Trp Lys Thr Val
            180                 185                 190         
Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr Gly Gln Ser Ala Leu
        195                 200                 205             
Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg Ala Leu Ile Leu Leu
    210                 215                 220                 
Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly Val Pro Thr Leu Thr
225                 230                 235                 240 
Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln Trp Glu Ala Ala Lys
                245                 250                 255     
Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg His Gly Ile Ile Leu
            260                 265                 270         
Pro Asn Asp Trp Lys Phe Asn Thr Val Asn Leu Lys Ser Ala Met Pro
        275                 280                 285             
Asn Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala Gly Ile Ala Arg Ala
    290                 295                 300                 
Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn Met Gly Val Gln Ala
305                 310                 315                 320 
Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln Gln Thr Ile Ile Ser
                325                 330                 335     
Leu Gln Arg Glu Phe Ala Ser Ala Ala Asn Leu Tyr Leu Ile Pro Lys
            340                 345                 350         
Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg Phe Pro Arg Leu Thr
        355                 360                 365             
Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala Ala Ala Asn Leu Met
    370                 375                 380                 
Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu Asp Ile Pro Thr Glu
385                 390                 395                 400 
Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys Met Arg Arg Ala Leu
                405                 410                 415     
Gly Val Val Asp Glu Val Arg Glu Ala Val Arg Gln Pro Ala Asp
            420                 425                 430     


<210> 34
<211> 1353
<212> DNA
<213> Artificial Sequence

<220> 
<223> SIN3

<400> 34
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaagca gtaagaaaag tggaagctat agcggcagca aaggcagcaa gctcgagggc 120
gcctccgtgc cggtgatgtc caccagttac gacgtggtgg tggaccggga gtttgacgag 180
tgtctgcagg gcaaggacgg cttgctcgtc taccacaaga tgctctcgga cggcacggtt 240
aagaacgccc tcaactacat cttcggacgc atccgctcgg cgaagtggta cgtagagccc 300
gcctctaccg acccggaaga catcgccatc gccgccttca tccacgccca gttaggcata 360
gacgacgctt cggtgggcaa gtatcccttt ggccgccttt tcgccatcta cgaaaacgcc 420
tacatatacg gcatggccgc cggggaaatc gtactaaccc ttggcgcgga cggcaagctc 480
atccttgaca aaatcgtccc tatccaccct ttcaacattg acgaggtgct ttacgacgag 540
gaaggcggtc caaaggcgct aaagctaagc ggagaggtga agggcggaag ccagtttgtg 600
agcgggttgg agattcctat atggaagacc gtggtcttcc tgcacaacga cgacggctcc 660
ttcaccggac agagcgccct cagagccgcc gtgccgcatt ggctagccaa acgagccctc 720
attctcctca tcaaccacgg gttggagcgc ttcatgattg gcgtgcccac cctcaccatc 780
cccaagagcg tgcgtcaggg aaccaagcaa tgggaggccg ccaaggaaat cgtcaagaac 840
tttgttcaaa aaccacggca tggtataata ctgcctaacg actggaagtt taacacggta 900
aacctgaagt cggccatgcc caacgccatt ccctacctga cctaccacga cgcgggcatc 960
gctagggcgc ttggcataga cttcaacacc gttcaactaa acatgggggt acaggcgata 1020
aacatcggcg agttcgtaag cctgacccag cagaccatca tttcgctcca gcgggagttc 1080
gctagcgcgg ccaacctcta cctcatcccc aagctagtgc ttcccaactg gccgagcgct 1140
actcgctttc ctaggctcac ctttgagatg gaggagcgca acgacttctc cgccgcggcc 1200
aaccttatgg gcatgctcat caacgcggtt aaggactccg aagacattcc caccgagctc 1260
aaggcgctaa tagacgctct gcctagcaag atgcgccggg cgcttggcgt ggtggacgag 1320
gtgagggaag cggtacgcca acccgccgat taa                              1353

<210> 35
<211> 426
<212> PRT
<213> Artificial Sequence

<220> 
<223> SIN4

<400> 35
Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met Ser Thr Ser
 1               5                  10                  15      
Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Gly Tyr Arg Pro Gly
            20                  25                  30          
Phe Tyr Phe Arg Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His
        35                  40                  45              
Lys Met Leu Ser Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe
    50                  55                  60                  
Gly Arg Ile Arg Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp
65                  70                  75                  80  
Pro Glu Asp Ile Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile
                85                  90                  95      
Asp Asp Ala Ser Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile
            100                 105                 110         
Tyr Glu Asn Ala Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu
        115                 120                 125             
Thr Leu Gly Ala Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile
    130                 135                 140                 
His Pro Phe Asn Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro
145                 150                 155                 160 
Lys Ala Leu Lys Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val
                165                 170                 175     
Ser Gly Leu Glu Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn
            180                 185                 190         
Asp Asp Gly Ser Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro
        195                 200                 205             
His Trp Leu Ala Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu
    210                 215                 220                 
Glu Arg Phe Met Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val
225                 230                 235                 240 
Arg Gln Gly Thr Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn
                245                 250                 255     
Phe Val Gln Lys Pro Arg His Gly Ile Ile Leu Pro Asn Asp Trp Lys
            260                 265                 270         
Phe Asn Thr Val Asn Leu Lys Ser Ala Met Pro Asn Ala Ile Pro Tyr
        275                 280                 285             
Leu Thr Tyr His Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe
    290                 295                 300                 
Asn Thr Val Gln Leu Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu
305                 310                 315                 320 
Phe Val Ser Leu Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe
                325                 330                 335     
Ala Ser Ala Val Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn
            340                 345                 350         
Trp Pro Ser Ala Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu
        355                 360                 365             
Arg Asn Asp Phe Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn
    370                 375                 380                 
Ala Val Lys Asp Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile
385                 390                 395                 400 
Asp Ala Leu Pro Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu
                405                 410                 415     
Val Arg Glu Ala Val Arg Gln Pro Ala Asp
            420                 425     


<210> 36
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> SIN4

<400> 36
atgggcagca gccatcatca tcatcatcac agcagcggcc tggaagttct gttccaggga 60
ccagcaaagc tcgagggcgc ctccgtgccg gtgatgtcca ccagttacga cgtggtggtg 120
gaccgggagt ttgacgaggg atatcgcccg ggcttttatt ttcgcctact gcagggcaag 180
gacggcttgc tcgtctacca caagatgctc tcggacggca cggttaagaa cgccctcaac 240
tacatcttcg gacgcatccg ctcggcgaag tggtacgtag agcccgcctc taccgacccg 300
gaagacatcg ccatcgccgc cttcatccac gcccagttag gcatagacga cgcttcggtg 360
ggcaagtatc cctttggccg ccttttcgcc atctacgaaa acgcctacat atacggcatg 420
gccgccgggg aaatcgtact aacccttggc gcggacggca agctcatcct tgacaaaatc 480
gtccctatcc accctttcaa cattgacgag gtgctttacg acgaggaagg cggtccaaag 540
gcgctaaagc taagcggaga ggtgaagggc ggaagccagt ttgtgagcgg gttggagatt 600
cctatatgga agaccgtggt cttcctgcac aacgacgacg gctccttcac cggacagagc 660
gccctcagag ccgccgtgcc gcattggcta gccaaacgag ccctcattct cctcatcaac 720
cacgggttgg agcgcttcat gattggcgtg cccaccctca ccatccccaa gagcgtgcgt 780
cagggaacca agcaatggga ggccgccaag gaaatcgtca agaactttgt tcaaaaacca 840
cggcatggta taatactgcc taacgactgg aagtttaaca cggtaaacct gaagtcggcc 900
atgcccaacg ccattcccta cctgacctac cacgacgcgg gcatcgctag ggcgcttggc 960
atagacttca acaccgttca actaaacatg ggggtacagg cgataaacat cggcgagttc 1020
gtaagcctga cccagcagac catcatttcg ctccagcggg agttcgctag cgcggtcaac 1080
ctctacctca tccccaagct agtgcttccc aactggccga gcgctactcg ctttcctagg 1140
ctcacctttg agatggagga gcgcaacgac ttctccgccg cggccaacct tatgggcatg 1200
ctcatcaacg cggttaagga ctccgaagac attcccaccg agctcaaggc gctaatagac 1260
gctctgccta gcaagatgcg ccgggcgctt ggcgtggtgg acgaggtgag ggaagcggta 1320
cgccaacccg ccgattaa                                               1338

<210> 37
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> 400C

<400> 37
Met Ala Lys Arg Gly Arg Lys Pro Lys Glu Leu Val Pro Gly Pro Gly
 1               5                  10                  15      
Ser Ile Asp Pro Ser Asp Val Pro Lys Leu Glu Gly Ala Ser Val Pro
            20                  25                  30          
Val Met Ser Thr Ser Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu
        35                  40                  45              
Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser
    50                  55                  60                  
Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg
65                  70                  75                  80  
Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile
                85                  90                  95      
Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser
            100                 105                 110         
Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala
        115                 120                 125             
Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala
    130                 135                 140                 
Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn
145                 150                 155                 160 
Ile Asp Glu Val Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu
                165                 170                 175     
Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile
            180                 185                 190         
Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe
        195                 200                 205             
Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys
    210                 215                 220                 
Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile
225                 230                 235                 240 
Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys
                245                 250                 255     
Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro
            260                 265                 270         
Arg His Gly Ile Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp
        275                 280                 285             
Leu Lys Ser Ala Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp
    290                 295                 300                 
Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu
305                 310                 315                 320 
Asn Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr
                325                 330                 335     
Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn
            340                 345                 350         
Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr
        355                 360                 365             
Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser
    370                 375                 380                 
Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala Val Lys Cys Ser
385                 390                 395                 400 
Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser
                405                 410                 415     
Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val
            420                 425                 430         
Arg Gln Pro Ala Asp Leu Glu His His His His His His
        435                 440                 445 


<210> 38
<211> 1341
<212> DNA
<213> Artificial Sequence

<220> 
<223> 400C

<220> 
<221> misc_feature   
<222> 494
<223> n = A,T,C or G

<400> 38
atggctaagc gaggacgtaa acccaaagag ctggtccccg gacctggctc cattgaccca 60
tctgacgttc ccaagctcga gggcgcctcc gtgccggtga tgtccaccag ttacgacgtg 120
gtggtggacc gggagtttga cgagctactg cagggcaagg acggcttgct cgtctaccac 180
aagatgctct cggacggcac ggttaagaac gccctcaact acatcttcgg acgcatccgc 240
tcggcgaagt ggtacgtaga gcccgcctct accgacccgg aagacatcgc catcgccgcc 300
ttcatccacg cccagttagg catagacgac gcttcggtgg gcaagtatcc ctttggccgc 360
cttttcgcca tctacgaaaa cgcctacata tacggcatgg ccgccgggga aatcgtacta 420
acccttggcg cggacggcaa gctcatcctt gacaaaatcg tccctatcca ccctttcaac 480
attgacgagg tgcnttacga cgaggaaggc ggtccaaagg cgctaaagct aagcggagag 540
gtgaagggcg gaagccagtt tgtgagcggg ttggagattc ctatatggaa gaccgtggtc 600
ttcctgcaca acgacgacgg ctccttcacc ggacagagcg ccctcagagc cgccgtgccg 660
cattggctag ccaaacgagc cctcattctc ctcatcaacc acgggttgga gcgcttcatg 720
attggcgtgc ccaccctcac catccccaag agcgtgcgtc agggaaccaa gcaatgggag 780
gccgccaagg aaatcgtcaa gaactttgtt caaaaaccac ggcatggtat aatactgcct 840
gacgactgga agtttgacac ggtagacctg aagtcggcca tgcccgacgc cattccctac 900
ctgacctacc acgacgcggg catcgctagg gcgcttggca tagacttcaa caccgttcaa 960
ctaaacatgg gggtacaggc gataaacatc ggcgagttcg taagcctgac ccagcagacc 1020
atcatttcgc tccagcggga gttcgctagc gcggtcaacc tctacctcat ccccaagcta 1080
gtgcttccca actggccgag cgctactcgc tttcctaggc tcacctttga gatggaggag 1140
cgcaacgact tctccgccgc ggccaacctt atgggcatgc tcatcaacgc ggttaagtgc 1200
tccgaagaca ttcccaccga gctcaaggcg ctaatagacg ctctgcctag caagatgcgc 1260
cgggcgcttg gcgtggtgga cgaggtgagg gaagcggtac gccaacccgc cgatctcgag 1320
caccaccacc accaccactg a                                           1341

<210> 39
<211> 436
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thermus Thermophilus Bacteriophage G20C and
      Affinity Tag; WT Nanopore

<400> 39
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Glu Val
 1               5                  10                  15      
Leu Phe Gln Gly Pro Ala Lys Leu Glu Gly Ala Ser Val Pro Val Met
            20                  25                  30          
Ser Thr Ser Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu Leu Leu
        35                  40                  45              
Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser Asp Gly
    50                  55                  60                  
Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg Ser Ala
65                  70                  75                  80  
Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile Ala Ile
                85                  90                  95      
Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser Val Gly
            100                 105                 110         
Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala Tyr Ile
        115                 120                 125             
Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala Asp Gly
    130                 135                 140                 
Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn Ile Asp
145                 150                 155                 160 
Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys Leu Ser
                165                 170                 175     
Gly Glu Val Lys Gly Gly Ser Gln Phe Val Ser Gly Leu Glu Ile Pro
            180                 185                 190         
Ile Trp Lys Thr Val Val Phe Leu His Asn Asp Asp Gly Ser Phe Thr
        195                 200                 205             
Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala Lys Arg
    210                 215                 220                 
Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met Ile Gly
225                 230                 235                 240 
Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr Lys Gln
                245                 250                 255     
Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys Pro Arg
            260                 265                 270         
His Gly Ile Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val Asp Leu
        275                 280                 285             
Lys Ser Ala Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His Asp Ala
    290                 295                 300                 
Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln Leu Asn
305                 310                 315                 320 
Met Gly Val Gln Ala Ile Asn Ile Gly Glu Phe Val Ser Leu Thr Gln
                325                 330                 335     
Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val Asn Leu
            340                 345                 350         
Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp Pro Ser Ala Thr Arg
        355                 360                 365             
Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe Ser Ala
    370                 375                 380                 
Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp Ser Glu
385                 390                 395                 400 
Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro Ser Lys
                405                 410                 415     
Met Arg Arg Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala Val Arg
            420                 425                 430         
Gln Pro Ala Asp
        435     


<210> 40
<211> 448
<212> PRT
<213> Thermus thermophilus bacteriophage P23-45

<400> 40
Met Ala Lys Arg Gly Arg Lys Pro Lys Glu Leu Val Pro Gly Pro Gly
 1               5                  10                  15      
Ser Ile Asp Pro Ser Asp Val Pro Lys Leu Glu Gly Ala Ser Val Pro
            20                  25                  30          
Val Met Ser Thr Ser Tyr Asp Val Val Val Asp Arg Glu Phe Asp Glu
        35                  40                  45              
Leu Leu Gln Gly Lys Asp Gly Leu Leu Val Tyr His Lys Met Leu Ser
    50                  55                  60                  
Asp Gly Thr Val Lys Asn Ala Leu Asn Tyr Ile Phe Gly Arg Ile Arg
65                  70                  75                  80  
Ser Ala Lys Trp Tyr Val Glu Pro Ala Ser Thr Asp Pro Glu Asp Ile
                85                  90                  95      
Ala Ile Ala Ala Phe Ile His Ala Gln Leu Gly Ile Asp Asp Ala Ser
            100                 105                 110         
Val Gly Lys Tyr Pro Phe Gly Arg Leu Phe Ala Ile Tyr Glu Asn Ala
        115                 120                 125             
Tyr Ile Tyr Gly Met Ala Ala Gly Glu Ile Val Leu Thr Leu Gly Ala
    130                 135                 140                 
Asp Gly Lys Leu Ile Leu Asp Lys Ile Val Pro Ile His Pro Phe Asn
145                 150                 155                 160 
Ile Asp Glu Val Leu Tyr Asp Glu Glu Gly Gly Pro Lys Ala Leu Lys
                165                 170                 175     
Leu Ser Gly Glu Val Lys Gly Gly Ser Gln Phe Val Asn Gly Leu Glu
            180                 185                 190         
Ile Pro Ile Trp Lys Thr Val Val Phe Leu His Asn Asp Asp Gly Ser
        195                 200                 205             
Phe Thr Gly Gln Ser Ala Leu Arg Ala Ala Val Pro His Trp Leu Ala
    210                 215                 220                 
Lys Arg Ala Leu Ile Leu Leu Ile Asn His Gly Leu Glu Arg Phe Met
225                 230                 235                 240 
Ile Gly Val Pro Thr Leu Thr Ile Pro Lys Ser Val Arg Gln Gly Thr
                245                 250                 255     
Lys Gln Trp Glu Ala Ala Lys Glu Ile Val Lys Asn Phe Val Gln Lys
            260                 265                 270         
Pro Arg His Gly Ile Ile Leu Pro Asp Asp Trp Lys Phe Asp Thr Val
        275                 280                 285             
Asp Leu Lys Ser Ala Met Pro Asp Ala Ile Pro Tyr Leu Thr Tyr His
    290                 295                 300                 
Asp Ala Gly Ile Ala Arg Ala Leu Gly Ile Asp Phe Asn Thr Val Gln
305                 310                 315                 320 
Leu Asn Met Gly Val Gln Ala Val Asn Ile Gly Glu Phe Val Ser Leu
                325                 330                 335     
Thr Gln Gln Thr Ile Ile Ser Leu Gln Arg Glu Phe Ala Ser Ala Val
            340                 345                 350         
Asn Leu Tyr Leu Ile Pro Lys Leu Val Leu Pro Asn Trp Pro Gly Ala
        355                 360                 365             
Thr Arg Phe Pro Arg Leu Thr Phe Glu Met Glu Glu Arg Asn Asp Phe
    370                 375                 380                 
Ser Ala Ala Ala Asn Leu Met Gly Met Leu Ile Asn Ala Val Lys Asp
385                 390                 395                 400 
Ser Glu Asp Ile Pro Thr Glu Leu Lys Ala Leu Ile Asp Ala Leu Pro
                405                 410                 415     
Ser Lys Met Arg Arg Ala Leu Gly Val Val Asp Glu Val Arg Glu Ala
            420                 425                 430         
Val Arg Gln Pro Ala Asp Ser Arg Tyr Leu Tyr Thr Arg Arg Arg Arg
        435                 440                 445             


<210> 41
<211> 1347
<212> DNA
<213> Thermus thermophilus bacteriophage P23-45

<400> 41
atggctaagc gaggacgtaa acccaaggag ctggtccccg gacctggctc cattgaccca 60
tccgacgttc ccaagctcga gggcgcctcc gtgccggtga tgtccaccag ctacgacgtg 120
gtggttgacc gggagtttga cgagctactg cagggcaagg acggcctgct cgtctaccac 180
aagatgctct cggacggcac ggtcaagaac gccctcaact acatcttcgg gcgcatccgc 240
tcggcgaagt ggtacgtaga gcccgcctct accgacccgg aggacatcgc catcgccgcc 300
ttcatccacg cccagttagg catagacgat gcttcggtag gcaagtatcc ttttggccgt 360
cttttcgcca tctacgaaaa cgcctacata tacggcatgg ccgccgggga aatcgtactg 420
acccttggcg cggacggcaa gctcatcctt gacaaaatcg tccctatcca ccctttcaac 480
attgacgagg tgctttacga cgaggaaggc ggtccaaagg cgctaaagct aagcggagag 540
gtgaagggcg gaagccagtt cgtgaacggg ctggagattc ctatctggaa gaccgtggtc 600
ttcctgcaca acgacgacgg ctccttcacc ggacagagcg ccctcagagc cgccgttccg 660
cattggctag ccaaacgcgc ccttatcctc ctcatcaacc acgggctaga gcgcttcatg 720
attggcgtgc ccaccctcac catccccaag agcgtgcgtc aggggaccaa gcaatgggag 780
gccgccaagg aaatcgtcaa gaactttgtt caaaaaccac ggcatggtat aatactgcct 840
gacgactgga agtttgacac ggtagacctg aagtcggcca tgcccgacgc cattccctac 900
ctgacctacc acgacgcggg catcgctagg gcgcttggca tagacttcaa caccgttcag 960
ctaaacatgg gggtacaggc ggtcaacatc ggcgagttcg taagcctgac ccagcagacc 1020
atcatttcgc tccagcggga gttcgctagc gcggtcaacc tctacctcat ccccaagcta 1080
gtgcttccca actggccggg cgccacccgc tttcccaggc tcacctttga gatggaggag 1140
cgtaacgact tctccgccgc ggccaacctt atgggcatgc tcatcaacgc ggttaaggac 1200
tccgaagaca ttcccaccga gctcaaggcg ctaatagacg ctctgcccag caagatgcgc 1260
cgggcgcttg gcgtggtgga cgaggtgagg gaagcggtac gccaacccgc cgattcccgc 1320
tacctgtaca cgcgaaggag gaggtag                                     1347
