                         SEQUENCE LISTING

<110>  REGENERON PHARMACEUTICALS, INC.
       CYGNAR, Katherine
       BAIK, Andrew
       SCHOENHERR, Christopher
       MURPHY, Andrew J.
 
<120>  ANTI-CD63 ANTIBODIES, CONJUGATES, AND USES THEREOF

<130>  009108.473WO1/10473WO01

<150>  62/673,098
<151>  2018-05-17

<150>  62/681,563
<151>  2018-06-06

<150>  62/777,592
<151>  2018-12-10

<160>  372   

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  1
caggtgcagc tgcaggagtc gggccccgga ctgatgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccttcagc agttactatt ggaactggat ccggcagtcc      120

ccagggaagg gactggagtg gattgggtat atccgttata gtggggacac caactacaag      180

ccctccctca agagtcgatt caccatatca attgacacgt ccaagaacct tttctccctg      240

aggctgaaat ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag gatgggactg      300

gggagtgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttca            354


<210>  2
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Arg Tyr Ser Gly Asp Thr Asn Tyr Lys Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Ile Asp Thr Ser Lys Asn Leu Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Gly Leu Gly Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  3
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  3
ggtggctcct tcagcagtta ctat                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Gly Ser Phe Ser Ser Tyr Tyr 
1               5               


<210>  5
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5
atccgttata gtggggacac c                                                 21


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Arg Tyr Ser Gly Asp Thr 
1               5           


<210>  7
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  7
gcgaggatgg gactggggag tgatgctttt gatatc                                 36


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Arg Met Gly Leu Gly Ser Asp Ala Phe Asp Ile 
1               5                   10          


<210>  9
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  9
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaattatt tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgtattca acagggccac taacatccca      180

gacaggttca gtggcagtgg gtctgggaca gatttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gttcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  10
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Val Phe Asn Arg Ala Thr Asn Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  11
cagagtgtta acaacaatta t                                                 21


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ser Val Asn Asn Asn Tyr 
1               5           


<210>  13
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  13
ggtgtattc                                                                9


<210>  14
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Val Phe 
1           


<210>  15
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  15
cagcagtatg gtagttcacc ttggacg                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  17
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  17
caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcggagac cctgtccctc       60

acctgcattg tctctggtgg ctccatcagt aatttctact ggaactggat ccggcagtcc      120

ccagggaagg gactggaatg gattggatat ttcttttaca ctgggactat cgactacaac      180

ccctccctca agagtcgagt caccatatca ctggacacgt ccaagaacca gttctccctg      240

aacctgcgtc ttctgaccgc cgcagacgcg gccgtttatt attgtgcgag gatggggctg      300

ggggctaatg cttttgacat ctggggccac gggacaatgg tcaccgtctc ttca            354


<210>  18
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ile Val Ser Gly Gly Ser Ile Ser Asn Phe 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Phe Tyr Thr Gly Thr Ile Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Arg Leu Leu Thr Ala Ala Asp Ala Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Gly Leu Gly Ala Asn Ala Phe Asp Ile Trp Gly His Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  19
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  19
ggtggctcca tcagtaattt ctac                                              24


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Gly Ser Ile Ser Asn Phe Tyr 
1               5               


<210>  21
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  21
ttcttttaca ctgggactat c                                                 21


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Phe Tyr Thr Gly Thr Ile 
1               5           


<210>  23
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  23
gcgaggatgg ggctgggggc taatgctttt gacatc                                 36


<210>  24
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Arg Met Gly Leu Gly Ala Asn Ala Phe Asp Ile 
1               5                   10          


<210>  25
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  25
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctcctggaga aagagccacc       60

ctctcctgca gggccagtca gcatgttagc agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtggatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgcagatt ttgcagtgtt ttactgtcag cagtatggta actcaccttg gacgttcggc      300

caagggacca aggtggaaat gaaa                                             324


<210>  26
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln His Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Gly Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Ala Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Asn Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Met Lys 
            100                 105             


<210>  27
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  27
cagcatgtta gcagcaacta c                                                 21


<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln His Val Ser Ser Asn Tyr 
1               5           


<210>  29
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  29
ggtggatcc                                                                9


<210>  30
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Gly Ser 
1           


<210>  31
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  31
cagcagtatg gtaactcacc ttggacg                                           27


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Gln Tyr Gly Asn Ser Pro Trp Thr 
1               5                   


<210>  33
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  33
caggtgcaac tacaggagtc gggcccaaag gtggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggaattggat ccgccagtcc      120

ccagggaagg gactggagtg gattggatat accaaaagag ggtataccga ctacaacccc      180

tccctcagga gtcgcgtcac tatatcagaa gacacgtcca agaaccagtt ctccctgagg      240

atcagctctg tgaccgccgc agacacggcc gtatattact gtgcacaaat ggggtgggga      300

tcccatgctt ttgacatgtg gggccaaggg acaatggtcg ccgtctcttc a               351


<210>  34
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Lys Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Thr Lys Arg Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Arg Ser 
    50                  55                  60                  


Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg 
65                  70                  75                  80  


Ile Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Gln 
                85                  90                  95      


Met Gly Trp Gly Ser His Ala Phe Asp Met Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Ala Val Ser Ser 
        115         


<210>  35
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  35
ggtggctcca tcagtagtta ctac                                              24


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  37
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  37
accaaaagag ggtatacc                                                     18


<210>  38
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Lys Arg Gly Tyr Thr 
1               5       


<210>  39
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  39
gcacaaatgg ggtggggatc ccatgctttt gacatg                                 36


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Gln Met Gly Trp Gly Ser His Ala Phe Asp Met 
1               5                   10          


<210>  41
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  41
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  42
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  43
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  43
cagagtgtta gcagcagcta c                                                 21


<210>  44
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  45
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  45
ggtgcatcc                                                                9


<210>  46
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Ala Ser 
1           


<210>  47
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  47
cagcagtatg gtagctcacc ttggacg                                           27


<210>  48
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  49
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  49
caggtgcaac tacaggagtc gggcccaaag gtggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggaattggat ccgccagtcc      120

ccagggaagg gactggagtg gattggatat accaaaagag ggtataccga ctacaacccc      180

tccctcagga gtcgcgtcac tatatcagaa gacacgtcca agaaccagtt ctccctgagg      240

atcagctctg tgaccgccgc agacacggcc gtatattact gtgcacaaat ggggtgggga      300

tcccatgctt ttgacatgtg gggccaaggg acaatggtcg ccgtctcttc a               351


<210>  50
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Pro Lys Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Thr Lys Arg Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Arg Ser 
    50                  55                  60                  


Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg 
65                  70                  75                  80  


Ile Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Gln 
                85                  90                  95      


Met Gly Trp Gly Ser His Ala Phe Asp Met Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Ala Val Ser Ser 
        115         


<210>  51
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  51
ggtggctcca tcagtagtta ctac                                              24


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  53
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  53
accaaaagag ggtatacc                                                     18


<210>  54
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  54

Thr Lys Arg Gly Tyr Thr 
1               5       


<210>  55
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  55
gcacaaatgg ggtggggatc ccatgctttt gacatg                                 36


<210>  56
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Gln Met Gly Trp Gly Ser His Ala Phe Asp Met 
1               5                   10          


<210>  57
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  57
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaat agtaggtact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggtgca gtggcagtgg gtccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc      300

caggggacca aggtggaaat caaa                                             324


<210>  58
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Cys Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  59
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  59
cagagtgtta atagtaggta c                                                 21


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Ser Val Asn Ser Arg Tyr 
1               5           


<210>  61
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  61
ggtgcatcc                                                                9


<210>  62
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  62

Gly Ala Ser 
1           


<210>  63
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  63
cagcagtatg gtagctcacc ttggacg                                           27


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  65
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  65
caggtgcagt tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctcgggatt catcttcagt gactactaca taaactggat tcgccaggct      120

ccagggaagg ggctggagtg ggtttcatat actagcagta gtggtagtac cacttattac      180

gaagactctg tgaagggccg attcaccatg tccagggaca atgccaggaa tttagtgtac      240

ctgcaaatga acagcctgag agccgaggac acggccgcgt attactgtgt gagagatctg      300

agatacaacg atggtttgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210>  66
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Thr Ser Ser Ser Gly Ser Thr Thr Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Arg Asn Leu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Arg Tyr Asn Asp Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  67
ggattcatct tcagtgacta ctac                                              24


<210>  68
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  68

Gly Phe Ile Phe Ser Asp Tyr Tyr 
1               5               


<210>  69
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  69
actagcagta gtggtagtac cact                                              24


<210>  70
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  70

Thr Ser Ser Ser Gly Ser Thr Thr 
1               5               


<210>  71
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  71
gtgagagatc tgagatacaa cgatggtttg gacgtc                                 36


<210>  72
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  72

Val Arg Asp Leu Arg Tyr Asn Asp Gly Leu Asp Val 
1               5                   10          


<210>  73
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  73
gacatcctgc tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattcgc acctatttaa attggtatca gcagaaacca      120

gggagagccc ctaagctcct ggtctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttactt ctgtcaacag agttatgata accctccgat caccttcggc      300

caggggacac gactggcgat taaa                                             324


<210>  74
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Ile Leu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Asp Asn Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Ala Ile Lys 
            100                 105             


<210>  75
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  75
cagagcattc gcacctat                                                     18


<210>  76
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Ser Ile Arg Thr Tyr 
1               5       


<210>  77
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  77
gctgcatcc                                                                9


<210>  78
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Ala Ser 
1           


<210>  79
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  79
caacagagtt atgataaccc tccgatcacc                                        30


<210>  80
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Gln Ser Tyr Asp Asn Pro Pro Ile Thr 
1               5                   10  


<210>  81
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  81
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggaactggat ccggcagtcc      120

ccagagaagg gactggagtg gattggatat atctatatca gtgggaccac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt tcaagaatca gttctccctg      240

aagctgaact ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag gatggggctg      300

gggagggagg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttca            354


<210>  82
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Ile Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Phe Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Gly Leu Gly Arg Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  83
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  83
ggtggctcca tcagtagtta ctac                                              24


<210>  84
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  84

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  85
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  85
atctatatca gtgggaccac c                                                 21


<210>  86
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  86

Ile Tyr Ile Ser Gly Thr Thr 
1               5           


<210>  87
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  87
gcgaggatgg ggctggggag ggaggctttt gatatc                                 36


<210>  88
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  88

Ala Arg Met Gly Leu Gly Arg Glu Ala Phe Asp Ile 
1               5                   10          


<210>  89
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  89
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aacaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  90
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  91
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  91
cagagtgtta gcaacaacta c                                                 21


<210>  92
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Ser Val Ser Asn Asn Tyr 
1               5           


<210>  93
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  93
ggtgcatcc                                                                9


<210>  94
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  94

Gly Ala Ser 
1           


<210>  95
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  95
cagcagtatg gtagctcacc ttggacg                                           27


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  97
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  97
caggtgcaac tggaggagtc tgggggaggc gtggtcaagg ctggagggtc cctgagactc       60

tcctgtgtag cctctggatt caccttcagt gactattaca taaactggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attaataatg gtggttatac catttactac      180

gcagactctg tgaagggccg attcaccatg tccagggaca acgccaagaa ctcagtatat      240

ctagaaatga acggcctgag agccgaggac acggcctttt attactgtgt gagagaccca      300

cggagttatt atgggtttga ctattggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  98
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  98

Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Val Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Asn Gly Gly Tyr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  99
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  99
ggattcacct tcagtgacta ttac                                              24


<210>  100
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  100

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  101
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  101
attaataatg gtggttatac catt                                              24


<210>  102
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  102

Ile Asn Asn Gly Gly Tyr Thr Ile 
1               5               


<210>  103
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  103
gtgagagacc cacggagtta ttatgggttt gactat                                 36


<210>  104
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  104

Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  105
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  105
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agttatttaa attggaatca gcagaaacca      120

gggaaagccc cgaagctcct gatctatgta gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcgg tctacaacct      240

gaagattttg caccttacta ctgtcaacag agttacatta cccctccgat caccttcggc      300

caagggacac gactggatat taaa                                             324


<210>  106
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Asn Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Pro Tyr Tyr Cys Gln Gln Ser Tyr Ile Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys 
            100                 105             


<210>  107
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  107
cagagcatta gcagttat                                                     18


<210>  108
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  108

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  109
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  109
gtagcatcc                                                                9


<210>  110
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  110

Val Ala Ser 
1           


<210>  111
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  111
caacagagtt acattacccc tccgatcacc                                        30


<210>  112
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln Gln Ser Tyr Ile Thr Pro Pro Ile Thr 
1               5                   10  


<210>  113
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  113
caggtgcaac tggaggagtc tgggggaggc gtggtcaagg ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactattaca taaattggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attaataatg gtggttatac catatactac      180

gcagactctg tgaagggccg attcaccatg tccagggaca acgccaagaa ctcagtatat      240

ctgcaaatga acggcctgag agccgaggac acggcctttt attactgtgt gagagaccca      300

cggagttatt atgggtttga ctattggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  114
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  114

Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Val Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Asn Gly Gly Tyr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  115
ggattcacct tcagtgacta ttac                                              24


<210>  116
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  116

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  117
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  117
attaataatg gtggttatac cata                                              24


<210>  118
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  118

Ile Asn Asn Gly Gly Tyr Thr Ile 
1               5               


<210>  119
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  119
gtgagagacc cacggagtta ttatgggttt gactat                                 36


<210>  120
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  120

Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  121
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  121
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagtattagc aggtttttac attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcac tctgcaacct      240

gaagactttg caacttacta ctgtcaacag agttatagta cccctccgat cactttcggc      300

caagggacac gactggagat taaa                                             324


<210>  122
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Phe 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  123
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  123
cagagtatta gcaggttt                                                     18


<210>  124
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Ser Ile Ser Arg Phe 
1               5       


<210>  125
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  125
ggtgcatcc                                                                9


<210>  126
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  126

Gly Ala Ser 
1           


<210>  127
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  127
caacagagtt atagtacccc tccgatcact                                        30


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  128

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  129
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  129
caggtgcacc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcagt gactactaca tgagctggat ccgacaggct      120

ccagggaagg ggctggagtg ggtttcatac atcagaggta gtggttataa cgcagactct      180

gtgcagggtc ggttcaccat ctccagggac aacgccaaga actcactgtt tctgcaaatg      240

aacagcctga gagccgagga cacggccgtg tattactgtg cgagaggata cagctttggt      300

tacggcttct ttgactactg gggccaggga accctggtca ccgtctcctc a               351


<210>  130
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  130

Gln Val His Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Arg Gly Ser Gly Tyr Asn Ala Asp Ser Val Gln Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
                85                  90                  95      


Tyr Ser Phe Gly Tyr Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  131
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  131
ggattcatct tcagtgacta ctac                                              24


<210>  132
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Phe Ile Phe Ser Asp Tyr Tyr 
1               5               


<210>  133
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  133
atcagaggta gtggttat                                                     18


<210>  134
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  134

Ile Arg Gly Ser Gly Tyr 
1               5       


<210>  135
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  135
gcgagaggat acagctttgg ttacggcttc tttgactac                              39


<210>  136
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  136

Ala Arg Gly Tyr Ser Phe Gly Tyr Gly Phe Phe Asp Tyr 
1               5                   10              


<210>  137
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  137
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggagagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagtc accctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  138
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  139
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  139
cagagcatta gcagctat                                                     18


<210>  140
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  140

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  141
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  141
gctgcatcc                                                                9


<210>  142
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  142

Ala Ala Ser 
1           


<210>  143
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  143
caacagagtt acagtcaccc tccgatcacc                                        30


<210>  144
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  144

Gln Gln Ser Tyr Ser His Pro Pro Ile Thr 
1               5                   10  


<210>  145
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  145
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcact gactacttca tgaactggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtaata gtggtgctat aaaataccaa      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttctttgtat      240

ctgcaaatga acagcctgag agccgacgac acggccgtgt attactgtgt gagagaccca      300

cggagctact atgggtttga ctattggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  146
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  146

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Ala Ile Lys Tyr Gln Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  147
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  147
ggattcacct tcactgacta cttc                                              24


<210>  148
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  148

Gly Phe Thr Phe Thr Asp Tyr Phe 
1               5               


<210>  149
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  149
attagtaata gtggtgctat aaaa                                              24


<210>  150
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  150

Ile Ser Asn Ser Gly Ala Ile Lys 
1               5               


<210>  151
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  151
gtgagagacc cacggagcta ctatgggttt gactat                                 36


<210>  152
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  152

Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  153
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  153
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagg aattttttaa attggtatca gcagaaacca      120

gggaaagccc ctaggctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcggtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta accctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  154
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  155
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  155
cagagcatta ggaatttt                                                     18


<210>  156
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  156

Gln Ser Ile Arg Asn Phe 
1               5       


<210>  157
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  157
gctgcatcc                                                                9


<210>  158
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  158

Ala Ala Ser 
1           


<210>  159
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  159
caacagagtt acagtaaccc tccgatcacc                                        30


<210>  160
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  160

Gln Gln Ser Tyr Ser Asn Pro Pro Ile Thr 
1               5                   10  


<210>  161
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  161
caggtgcaac tggaggagtc tgggggaggc gtggtcaagg ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactattaca tgaactggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attaataatg gtggttatac catatactac      180

gcagactctg tgaagggccg attcaccatg tccagggaca acgccaagaa ctcagtgtat      240

ctgcaaatga acggcctgag agccgaggac acggcctttt attactgtgt gagagaccca      300

cggagctatt atgggtttga ctactggggc cagggaaccc tggtcatcgt ctcctca         357


<210>  162
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  162

Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Val Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Asn Gly Gly Tyr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ile Val Ser Ser 
        115                 


<210>  163
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  163
ggattcacct tcagtgacta ttac                                              24


<210>  164
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  164

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  165
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  165
attaataatg gtggttatac cata                                              24


<210>  166
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  166

Ile Asn Asn Gly Gly Tyr Thr Ile 
1               5               


<210>  167
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  167
gtgagagacc cacggagcta ttatgggttt gactac                                 36


<210>  168
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  168

Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  169
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  169
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagtattagc aggtttttac attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttatagca cccctccgat cactttcggc      300

caagggacac gactggagat taaa                                             324


<210>  170
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  170

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Phe 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  171
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  171
cagagtatta gcaggttt                                                     18


<210>  172
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Ser Ile Ser Arg Phe 
1               5       


<210>  173
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  173
ggtgcatcc                                                                9


<210>  174
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  174

Gly Ala Ser 
1           


<210>  175
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  175
caacagagtt atagcacccc tccgatcact                                        30


<210>  176
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  176

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  177
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  177
caggtgcaac tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcaa cctctggatt caccttcggt gactactaca tgaactggtt tcgccaggct      120

ccagggaagg ggctggactg ggtttcatac attagtagta gtggtagtac cagatactac      180

gcagactctg tgaggggccg attcaccatc tccagggaca acgccaagaa ttcactgtac      240

ctgcaaatga acagtctgag agccgaggac acggccgtct attactgtgt gagagatctc      300

cgctactact acggtatgga cgtatggggc caagggacca cggtcaccgt ctcctca         357


<210>  178
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  178

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Arg Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  179
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  179
ggattcacct tcggtgacta ctac                                              24


<210>  180
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  180

Gly Phe Thr Phe Gly Asp Tyr Tyr 
1               5               


<210>  181
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  181
attagtagta gtggtagtac caga                                              24


<210>  182
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  182

Ile Ser Ser Ser Gly Ser Thr Arg 
1               5               


<210>  183
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  183
gtgagagatc tccgctacta ctacggtatg gacgta                                 36


<210>  184
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  184

Val Arg Asp Leu Arg Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  185
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  185
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aacaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  186
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  186

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  187
cagagtgtta gcaacaacta c                                                 21


<210>  188
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  188

Gln Ser Val Ser Asn Asn Tyr 
1               5           


<210>  189
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  189
ggtgcatcc                                                                9


<210>  190
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  190

Gly Ala Ser 
1           


<210>  191
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  191
cagcagtatg gtagctcacc ttggacg                                           27


<210>  192
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  192

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  193
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  193
caggtgcaac tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggaactggat ccggcagtcc      120

ccagggaagg gactggagtg gattgggtat accaaaaaaa ggagtaccaa ctacaacccc      180

tccctcagga gtcgagtcac tatatcagaa gacacgtcca agaaccagtt ctccctgaag      240

atgagctctg tgaccgccgc agacacggcc gtatattact gtgcaaaaat ggggtgggga      300

tcccatgctt ttgatatatg gggccaaggg acaatggtca ccgtctcttc a               351


<210>  194
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  194

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Thr Lys Lys Arg Ser Thr Asn Tyr Asn Pro Ser Leu Arg Ser 
    50                  55                  60                  


Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
65                  70                  75                  80  


Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
                85                  90                  95      


Met Gly Trp Gly Ser His Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  195
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  195
ggtggctcca tcagtagtta ctac                                              24


<210>  196
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  196

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  197
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  197
accaaaaaaa ggagtacc                                                     18


<210>  198
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  198

Thr Lys Lys Arg Ser Thr 
1               5       


<210>  199
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  199
gcaaaaatgg ggtggggatc ccatgctttt gatata                                 36


<210>  200
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  200

Ala Lys Met Gly Trp Gly Ser His Ala Phe Asp Ile 
1               5                   10          


<210>  201
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  201
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  202
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  202

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  203
cagagtgtta gcagcagcta c                                                 21


<210>  204
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  204

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  205
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  205
ggtgcatcc                                                                9


<210>  206
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  206

Gly Ala Ser 
1           


<210>  207
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  207
cagcagtatg gtagctcacc ttggacg                                           27


<210>  208
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  208

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  209
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  209
caggtgcagc tgcaggaggc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcattg tctctggtgg ctccatcagt ggtttctact ggaattggat ccggcagccc      120

ccagggaagg gactggaatg gattggatat ttcctttaca gtgggactat cgactacaac      180

ccctccctca agagccgagt caccatatca gtggacacgt ccaaaaacca attctttctg      240

aagttgagtt ttgtgaccgc cgctgacacg gccgtttatt actgtgtgag gatgggactg      300

ggggctaatg cttttgacat ctggggccga gggacaatgg tcaccgtctc ttca            354


<210>  210
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  210

Gln Val Gln Leu Gln Glu Ala Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ile Val Ser Gly Gly Ser Ile Ser Gly Phe 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Leu Tyr Ser Gly Thr Ile Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Phe Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Met Gly Leu Gly Ala Asn Ala Phe Asp Ile Trp Gly Arg Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  211
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  211
ggtggctcca tcagtggttt ctac                                              24


<210>  212
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  212

Gly Gly Ser Ile Ser Gly Phe Tyr 
1               5               


<210>  213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  213
ttcctttaca gtgggactat c                                                 21


<210>  214
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  214

Phe Leu Tyr Ser Gly Thr Ile 
1               5           


<210>  215
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  215
gtgaggatgg gactgggggc taatgctttt gacatc                                 36


<210>  216
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  216

Val Arg Met Gly Leu Gly Ala Asn Ala Phe Asp Ile 
1               5                   10          


<210>  217
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  217
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagt aggagtttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtccatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gatttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcggtgta ttactgtcaa caatatggta actcaccttg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  218
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  218

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Arg Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Pro Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  219
cagactgtta gtaggagttt c                                                 21


<210>  220
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  220

Gln Thr Val Ser Arg Ser Phe 
1               5           


<210>  221
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  221
ggtccatcc                                                                9


<210>  222
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  222

Gly Pro Ser 
1           


<210>  223
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  223
caacaatatg gtaactcacc ttggacg                                           27


<210>  224
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  224

Gln Gln Tyr Gly Asn Ser Pro Trp Thr 
1               5                   


<210>  225
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  225
caggtccagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag tttctggatt cacctacact gactacttca tgaactggat ccgacaggct      120

ccagggaagg ggctggaatg ggtttcatat attagtaata gtggtgctat caaatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttctttgtat      240

ctgcaaatga acggcctgag agccgacgac acggccgtgt attactgtgt gagagaccct      300

cgaagctact atgggtttga ctattggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  226
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  226

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Tyr Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Ala Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  227
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  227
ggattcacct acactgacta cttc                                              24


<210>  228
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  228

Gly Phe Thr Tyr Thr Asp Tyr Phe 
1               5               


<210>  229
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  229
attagtaata gtggtgctat caaa                                              24


<210>  230
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  230

Ile Ser Asn Ser Gly Ala Ile Lys 
1               5               


<210>  231
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  231
gtgagagacc ctcgaagcta ctatgggttt gactat                                 36


<210>  232
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  232

Val Arg Asp Pro Arg Ser Tyr Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  233
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  233
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggtga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagt aactttttaa attggtatca gcagaaacca      120

gggaaagccc ctaggctcct gatctatggt gcatccaatt tgcaaagtgg ggtcccatca      180

aggttcagtg gcggtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gcagattttg caacttacta ctgtcagcag agtttcagta accctccggt caccttcggc      300

caagggacac gactggagat taac                                             324


<210>  234
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  234

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Asn Pro Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Asn 
            100                 105             


<210>  235
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  235
cagagcatta gtaacttt                                                     18


<210>  236
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  236

Gln Ser Ile Ser Asn Phe 
1               5       


<210>  237
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  237
ggtgcatcc                                                                9


<210>  238
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  238

Gly Ala Ser 
1           


<210>  239
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  239
cagcagagtt tcagtaaccc tccggtcacc                                        30


<210>  240
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  240

Gln Gln Ser Phe Ser Asn Pro Pro Val Thr 
1               5                   10  


<210>  241
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  241
caggtgcagt tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcggt gactactaca ttaactggat tcgccaggct      120

ccagggaagg ggctgcagtg ggtttcatat actagtagta gtggtagtac cacttactac      180

gaagactctg tgaagggccg attcaccatg tccagggaca atgccaagaa tttagtatac      240

ctgcaaatga acagcctgag agccgaggac acggccgcgt attattgtgt gagagatctg      300

agatacaacg atggtttgga cgtctggggc caagggacca cggtcatcgt ctcctca         357


<210>  242
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  242

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Tyr Thr Ser Ser Ser Gly Ser Thr Thr Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Leu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Arg Tyr Asn Asp Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Ile Val Ser Ser 
        115                 


<210>  243
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  243
ggattcatct tcggtgacta ctac                                              24


<210>  244
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  244

Gly Phe Ile Phe Gly Asp Tyr Tyr 
1               5               


<210>  245
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  245
actagtagta gtggtagtac cact                                              24


<210>  246
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  246

Thr Ser Ser Ser Gly Ser Thr Thr 
1               5               


<210>  247
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  247
gtgagagatc tgagatacaa cgatggtttg gacgtc                                 36


<210>  248
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  248

Val Arg Asp Leu Arg Tyr Asn Asp Gly Leu Asp Val 
1               5                   10          


<210>  249
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  249
gacatcctgc tgacccagtc tccatcctcc ctgtctgcat ttgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaacattcgc acctatctaa attggtatca gcagaaacca      120

gggagagccc ctaagctcct ggtctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagac ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caagttactt ctgtcaacag agttacgata accctccgat caccttcggc      300

caagggacac gactggcgat taaa                                             324


<210>  250
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  250

Asp Ile Leu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Phe Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Phe Cys Gln Gln Ser Tyr Asp Asn Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Ala Ile Lys 
            100                 105             


<210>  251
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  251
cagaacattc gcacctat                                                     18


<210>  252
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  252

Gln Asn Ile Arg Thr Tyr 
1               5       


<210>  253
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  253
gctgcatcc                                                                9


<210>  254
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  254

Ala Ala Ser 
1           


<210>  255
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  255
caacagagtt acgataaccc tccgatcacc                                        30


<210>  256
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  256

Gln Gln Ser Tyr Asp Asn Pro Pro Ile Thr 
1               5                   10  


<210>  257
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  257
gaagtgcaac tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtacag cctctggatt cacctttggt gatcatgcca tgcactgggt ccgacaagct      120

cccgggaagg gcctggaggg ggtctcaagt attaattgga atagtggtat cataggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acaatctgag agctgaggac acgggcttat attactgtgc aagggatatt      300

ggcgtggcaa cgcttggtat tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  258
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  258

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Asn Ser Gly Ile Ile Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Val Ala Thr Leu Gly Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  259
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  259
ggattcacct ttggtgatca tgcc                                              24


<210>  260
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  260

Gly Phe Thr Phe Gly Asp His Ala 
1               5               


<210>  261
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  261
attaattgga atagtggtat cata                                              24


<210>  262
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  262

Ile Asn Trp Asn Ser Gly Ile Ile 
1               5               


<210>  263
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  263
gcaagggata ttggcgtggc aacgcttggt attgactac                              39


<210>  264
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  264

Ala Arg Asp Ile Gly Val Ala Thr Leu Gly Ile Asp Tyr 
1               5                   10              


<210>  265
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  265
gacatccaga tgacccagtc tccatcctcc ctgtctgcat cagtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctactcaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agtcacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  266
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  266

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Ser Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  267
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  267
cagagcatta gcagctac                                                     18


<210>  268
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  268

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  269
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  269
gctgcatcc                                                                9


<210>  270
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  270

Ala Ala Ser 
1           


<210>  271
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  271
caacagagtc acagtacccc tccgatcacc                                        30


<210>  272
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  272

Gln Gln Ser His Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  273
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  273
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcaa cctctggatt caccttcact gactacttca tgaattggat ccgccaggct      120

ccagggaagg gactggagtg ggtttcatac attagtaaca gtggttctat cagatattat      180

gcagactctg tgaggggccg attctccatc tccagggaca atgccaagaa ctccctgtat      240

ctgcaaatga gcagcctgag agccgatgac acggccgtgt attactgtgt gagagatccg      300

cgacaaatct acggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210>  274
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  274

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Ser Ile Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Gln Ile Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  275
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  275
ggattcacct tcactgacta cttc                                              24


<210>  276
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  276

Gly Phe Thr Phe Thr Asp Tyr Phe 
1               5               


<210>  277
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  277
attagtaaca gtggttctat caga                                              24


<210>  278
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  278

Ile Ser Asn Ser Gly Ser Ile Arg 
1               5               


<210>  279
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  279
gtgagagatc cgcgacaaat ctacggtatg gacgtc                                 36


<210>  280
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  280

Val Arg Asp Pro Arg Gln Ile Tyr Gly Met Asp Val 
1               5                   10          


<210>  281
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  281
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  282
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  282

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  283
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  283
cagagcatta gcagctat                                                     18


<210>  284
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  284

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  285
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  285
gctgcatcc                                                                9


<210>  286
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  286

Ala Ala Ser 
1           


<210>  287
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  287
caacagagtt acagtacccc tccgatcacc                                        30


<210>  288
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  288

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  289
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  289
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctcgagggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcgat gactacttca tgaactggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtaata gtggtaatac caaatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgcctacaa ctctctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgt gagagatcct      300

agaagttact acggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210>  290
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  290

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Arg Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Asn Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Tyr Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Ser Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  291
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  291
ggattcatct tcgatgacta cttc                                              24


<210>  292
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  292

Gly Phe Ile Phe Asp Asp Tyr Phe 
1               5               


<210>  293
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  293
attagtaata gtggtaatac caaa                                              24


<210>  294
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  294

Ile Ser Asn Ser Gly Asn Thr Lys 
1               5               


<210>  295
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  295
gtgagagatc ctagaagtta ctacggtatg gacgtc                                 36


<210>  296
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  296

Val Arg Asp Pro Arg Ser Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  297
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  297
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgaactggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attaatggtg gtggttatac catgtactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactttat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagataga      300

aggactacag tatctattga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  298
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  298

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
1               5                   10                  15      


Ala Arg Asp Arg Arg Thr Thr Val Ser Ile Asp Tyr Trp Gly Gln Gly 
            20                  25                  30          


Thr Leu Val Thr Val Ser Ser 
        35                  


<210>  299
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  299
ggattcacct tcagtgacta ctac                                              24


<210>  300
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  300

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  301
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  301
attaatggtg gtggttatac catg                                              24


<210>  302
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  302

Ile Asn Gly Gly Gly Tyr Thr Met 
1               5               


<210>  303
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  303
gcgagagata gaaggactac agtatctatt gactac                                 36


<210>  304
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  304

Ala Arg Asp Arg Arg Thr Thr Val Ser Ile Asp Tyr 
1               5                   10          


<210>  305
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  305
gaagtgcagc tggtggagtc tgggggagcc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctagagtg ggtctcaggt attagttgga atagtggtac catgggctat      180

gcggactctg tgaagggccg attcaccatt tccagagaca acgccaagaa gtccctgtat      240

ctgcaaatga atagtctgag agctgaggac acggccttgt attactgtgg aaaaggtcta      300

cttcaccagt gggaggtact tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  306
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  306

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Thr Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Gly Leu Leu His Gln Trp Glu Val Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  307
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  307
ggattcacct ttgatgatta tgcc                                              24


<210>  308
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  308

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  309
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  309
attagttgga atagtggtac catg                                              24


<210>  310
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  310

Ile Ser Trp Asn Ser Gly Thr Met 
1               5               


<210>  311
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  311
ggaaaaggtc tacttcacca gtgggaggta cttgactac                              39


<210>  312
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  312

Gly Lys Gly Leu Leu His Gln Trp Glu Val Leu Asp Tyr 
1               5                   10              


<210>  313
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  313
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcact gattacttca tgaactggat ccgccaggct      120

ccaggaaagg ggctggagtg ggtttcgtac attagtaata gtggtaatat tttatactat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaaggc gtccctgtat      240

ctgcaaatga gcagccttaa agccgaggac acggccgtgt attactgtgt gagagatccc      300

cgtatgttct acggtatgga cgtctggggc caggggacca cggtcaccgt ctcctca         357


<210>  314
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  314

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Asn Ile Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ala Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Met Phe Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  315
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  315
ggattcatct tcactgatta cttc                                              24


<210>  316
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  316

Gly Phe Ile Phe Thr Asp Tyr Phe 
1               5               


<210>  317
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  317
attagtaata gtggtaatat ttta                                              24


<210>  318
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  318

Ile Ser Asn Ser Gly Asn Ile Leu 
1               5               


<210>  319
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  319
gtgagagatc cccgtatgtt ctacggtatg gacgtc                                 36


<210>  320
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  320

Val Arg Asp Pro Arg Met Phe Tyr Gly Met Asp Val 
1               5                   10          


<210>  321
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  321
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactata tgaattggat ccgccaggct      120

ccagggaagg gactggagtg gattacatac attaataatg gtggctatac caaatactac      180

gcagactctg tgaagggccg attcatcatc tccagggaca acaccaagaa ttcagtgcat      240

ttgcaaatga atagcctgag agccgaggac acggccgtgt attactgtgt gagagatccc      300

cgtatgtatt atggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210>  322
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  322

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Thr Tyr Ile Asn Asn Gly Gly Tyr Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ser Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Arg Met Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  323
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  323
ggattcacct tcagtgacta ctat                                              24


<210>  324
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  324

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  325
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  325
attaataatg gtggctatac caaa                                              24


<210>  326
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  326

Ile Asn Asn Gly Gly Tyr Thr Lys 
1               5               


<210>  327
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  327
gtgagagatc cccgtatgta ttatggtatg gacgtc                                 36


<210>  328
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  328

Val Arg Asp Pro Arg Met Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  329
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  329
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt gactactaca ttacctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attaatactg gtggttatac catgtattac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

cttcaaatga acaacctgag agccgaggac acggccgtgt attattgtac gagagatagg      300

agatacaact ttggtcttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  330
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  330

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Ile Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Thr Gly Gly Tyr Thr Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Arg Tyr Asn Phe Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  331
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  331
ggattctcct tcagtgacta ctac                                              24


<210>  332
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  332

Gly Phe Ser Phe Ser Asp Tyr Tyr 
1               5               


<210>  333
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  333
attaatactg gtggttatac catg                                              24


<210>  334
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  334

Ile Asn Thr Gly Gly Tyr Thr Met 
1               5               


<210>  335
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  335
acgagagata ggagatacaa ctttggtctt gactac                                 36


<210>  336
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  336

Thr Arg Asp Arg Arg Tyr Asn Phe Gly Leu Asp Tyr 
1               5                   10          


<210>  337
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  338
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD63 EC loop 2 MMH

<400>  338

Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met 
1               5                   10                  15      


Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met 
            20                  25                  30          


Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu 
        35                  40                  45              


Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile 
    50                  55                  60                  


Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His 
65                  70                  75                  80  


Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val 
                85                  90                  95      


Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys 
            100                 105                 110         


Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        115                 120                 125 


<210>  339
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD63 EC loop 2 hFC

<400>  339

Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met 
1               5                   10                  15      


Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met 
            20                  25                  30          


Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu 
        35                  40                  45              


Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile 
    50                  55                  60                  


Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His 
65                  70                  75                  80  


Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val 
                85                  90                  95      


Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            100                 105                 110         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        115                 120                 125             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    130                 135                 140                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
145                 150                 155                 160 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                165                 170                 175     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    210                 215                 220                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                245                 250                 255     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            260                 265                 270         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        275                 280                 285             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    290                 295                 300                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  340
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  340

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  341
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  341

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  342
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  342

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  343
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  343

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  344
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  344

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  345
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  345

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  346
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  346

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
145                 150                 155                 160 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            180                 185                 190         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    210                 215                 220                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
225                 230                 235                 240 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  347
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  347

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
145                 150                 155                 160 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            180                 185                 190         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    210                 215                 220                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
225                 230                 235                 240 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  348
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH sequence

<400>  348

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  349
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  349

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Leu Gly Lys 
                325     


<210>  350
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  350

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Leu Gly Lys 
                325     


<210>  351
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH sequence

<400>  351

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  352
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  352

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  353
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  353

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  354
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  354

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  355
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  355

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  356
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  356

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  357
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  357

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  358
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc sequence

<400>  358

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  359
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  359

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            100                 105                 110         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  360
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  360

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            100                 105                 110         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  361
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc sequence

<400>  361

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  362
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc sequence

<400>  362

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  363
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc sequence

<400>  363

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  364
<211>  1128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv_H4H123450(VH-linker-VL)_linker_GAA

<400>  364

Gln Val Gln Leu Gln Glu Ser Gly Pro Lys Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Thr Lys Arg Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Arg Ser 
    50                  55                  60                  


Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg 
65                  70                  75                  80  


Ile Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Gln 
                85                  90                  95      


Met Gly Trp Gly Ser His Ala Phe Asp Met Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Ala Val Ser Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
    130                 135                 140                 


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
                245                 250                 255     


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
            260                 265                 270         


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
        275                 280                 285             


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
    290                 295                 300                 


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
305                 310                 315                 320 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
                325                 330                 335     


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
            340                 345                 350         


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
        355                 360                 365             


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
    370                 375                 380                 


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
385                 390                 395                 400 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
                405                 410                 415     


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
            420                 425                 430         


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
        435                 440                 445             


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
    450                 455                 460                 


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
465                 470                 475                 480 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
                485                 490                 495     


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
            500                 505                 510         


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
        515                 520                 525             


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
    530                 535                 540                 


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
545                 550                 555                 560 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
                565                 570                 575     


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
            580                 585                 590         


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
        595                 600                 605             


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
    610                 615                 620                 


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
625                 630                 635                 640 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
                645                 650                 655     


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
            660                 665                 670         


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
        675                 680                 685             


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
    690                 695                 700                 


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
705                 710                 715                 720 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
                725                 730                 735     


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
            740                 745                 750         


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
        755                 760                 765             


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
    770                 775                 780                 


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
785                 790                 795                 800 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
                805                 810                 815     


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
            820                 825                 830         


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
        835                 840                 845             


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
    850                 855                 860                 


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
865                 870                 875                 880 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
                885                 890                 895     


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
            900                 905                 910         


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
        915                 920                 925             


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
    930                 935                 940                 


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
945                 950                 955                 960 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
                965                 970                 975     


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
            980                 985                 990         


His Leu Arg Ala Gly Tyr Ile Ile  Pro Leu Gln Gly Pro  Gly Leu Thr 
        995                 1000                 1005             


Thr Thr  Glu Ser Arg Gln Gln  Pro Met Ala Leu Ala  Val Ala Leu 
    1010                 1015                 1020             


Thr Lys  Gly Gly Glu Ala Arg  Gly Glu Leu Phe Trp  Asp Asp Gly 
    1025                 1030                 1035             


Glu Ser  Leu Glu Val Leu Glu  Arg Gly Ala Tyr Thr  Gln Val Ile 
    1040                 1045                 1050             


Phe Leu  Ala Arg Asn Asn Thr  Ile Val Asn Glu Leu  Val Arg Val 
    1055                 1060                 1065             


Thr Ser  Glu Gly Ala Gly Leu  Gln Leu Gln Lys Val  Thr Val Leu 
    1070                 1075                 1080             


Gly Val  Ala Thr Ala Pro Gln  Gln Val Leu Ser Asn  Gly Val Pro 
    1085                 1090                 1095             


Val Ser  Asn Phe Thr Tyr Ser  Pro Asp Thr Lys Val  Leu Asp Ile 
    1100                 1105                 1110             


Cys Val  Ser Leu Leu Met Gly  Glu Gln Phe Leu Val  Ser Trp Cys 
    1115                 1120                 1125             


<210>  365
<211>  141
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  365
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  366
<211>  141
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  366
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  367
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  367
gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg agcaaacagg       60

ggctaagtcc ac                                                           72


<210>  368
<211>  224
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  368
gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt       60

catatttgtg taggttactt attctccttt tgttgactaa gtcaataatc agaatcagca      120

ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg gtataaaagc      180

cccttcacca ggagaagccg tcacacagat ccacaagctc ctga                       224


<210>  369
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  370
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  370
ggaaccccta gtgatggagt t                                                 21


<210>  371
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  371
cggcctcagt gagcga                                                       16


<210>  372
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  372
cactccctct ctgcgcgctc g                                                 21


