                         SEQUENCE LISTING

<110>  SPARK THERAPEUTICS, INC.
       ANGUELA, Xavier
       ARMOUR, Sean
       NORDIN, Jayme
 
<120>  CODON-OPTIMIZED ACID ALPHA-GLUCOSIDASE EXPRESSION CASSETTES AND METHODS OF USING SAME

<130>  023637-0504752

<140>  PCT/US2019/032502
<141>  2019-05-15

<150>  62/672,419
<151>  2018-05-16

<150>  62/734,454
<151>  2018-09-21

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  1
atggctttcc tgtggctgct gagctgctgg gctctgctgg gcaccacctt tgggctgctg       60

gtgcctaggg agctgtctgg gtctagccct gtgctggagg agactcaccc tgcccatcag      120

cagggggcta gcaggcctgg ccccagggat gctcaggccc accctggcag gcccagggct      180

gtgcccaccc agtgtgatgt gccccccaac agcaggtttg actgtgcccc tgacaaggcc      240

attacccagg agcagtgtga ggccaggggc tgctgctaca ttccagctaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc ccagctatcc tagctataaa      360

ctggagaacc tgagcagctc tgagatgggc tatactgcca ccctgactag gactactccc      420

accttttttc ctaaggatat cctgaccctg aggctggatg tgatgatgga gactgagaac      480

aggctgcact tcactattaa ggaccctgcc aataggaggt atgaagtgcc tctggagact      540

cctcatgtgc actctagggc ccccagcccc ctgtattctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtgc tgctgaacac cactgtggcc      660

cccctgttct ttgctgacca gttcctgcag ctgagcacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcatct gagccctctg atgctgagca cctcttggac caggatcacc      780

ctgtggaata gggatctggc ccccacccct ggggctaatc tgtatggctc tcatcccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt ttctgctgaa cagcaatgcc      900

atggatgtgg tgctgcagcc ctctcctgcc ctgagctgga ggagcactgg gggcatcctg      960

gatgtgtaca tcttcctggg ccctgagccc aagtctgtgg tccagcagta tctggatgtg     1020

gtgggctacc cctttatgcc cccctattgg ggcctgggct tccacctgtg caggtggggg     1080

tattcttcta ctgctatcac caggcaggtg gtggagaaca tgaccagggc tcacttcccc     1140

ctggatgtgc agtggaatga cctggactat atggactcta ggagggattt caccttcaac     1200

aaggatggct tcagggactt ccctgctatg gtccaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgccatcagc agctctggcc ctgctggcag ctataggccc     1320

tatgatgagg gcctgaggag gggggtgttt atcactaatg aaactgggca gcccctgatt     1380

ggcaaggtgt ggcctggctc tactgccttc cctgacttca ccaaccccac tgctctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cttttgatgg catgtggatt     1500

gacatgaatg agcccagcaa cttcatcagg ggctctgagg atgggtgccc caataatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ccctgcaggc tgccactatt     1620

tgtgccagct ctcaccagtt cctgagcacc cactacaacc tgcacaatct gtatggcctg     1680

actgaggcca ttgccagcca cagggccctg gtgaaggcca ggggcactag gccctttgtg     1740

atctctagaa gcacctttgc tggccatggg aggtatgctg gccactggac tggggatgtg     1800

tggagctctt gggagcagct ggccagctct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcccc tggtgggggc tgatgtgtgt ggcttcctgg gcaacacctc tgaagagctg     1920

tgtgtgaggt ggacccagct gggggccttc taccctttca tgaggaacca caacagcctg     1980

ctgagcctgc ctcaggagcc ttactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc tctgctgccc cacctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg ttcctggagt ttcctaagga tagcagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgattacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tggctacttc cccctgggca cttggtatga cctgcagact     2280

gtgcctgtgg aagccctggg cagcctgcct cccccccctg ctgcccccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccccc tggacaccat taatgtgcat     2400

ctgagggctg ggtatattat ccccctgcag gggcctgggc tgactaccac tgagagcagg     2460

cagcagccta tggccctggc tgtggctctg actaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagaggg gggcctacac ccaggtgatt     2580

ttcctggcca ggaacaacac cattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaagt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tacagccctg acaccaaggt gctggatatt     2760

tgtgtgagcc tgctgatggg ggagcagttc ctggtgagct ggtgctga                  2808


<210>  2
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  2
atggctttcc tgtggctgct gtcttgctgg gccctgctgg ggactacctt tggcctgctg       60

gtgcccaggg aactgtctgg ctctagccca gtgctggagg agacccaccc tgcccaccag      120

cagggggctt ctaggcctgg ccccagggat gcccaggccc accctggcag gccaagggct      180

gtgcccaccc agtgtgatgt gccccccaac tctagatttg attgtgcccc tgataaggcc      240

atcacccagg agcagtgtga ggctaggggc tgctgctaca tccctgctaa gcagggcctg      300

cagggggctc agatgggcca gccctggtgc ttcttccccc ccagctatcc ctcttacaag      360

ctggagaatc tgagcagctc tgagatgggc tacactgcca ccctgaccag gactactccc      420

accttcttcc ccaaggacat cctgaccctg aggctggatg tgatgatgga gactgagaac      480

aggctgcatt tcaccatcaa ggatcctgcc aacaggaggt atgaggtgcc tctggagacc      540

ccccatgtgc acagcagggc tccttctccc ctgtactctg tggagttctc tgaggaaccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtcc tgctgaacac cactgtggcc      660

cccctgttct ttgctgatca gttcctgcag ctgtccactt ctctgcctag ccagtacatc      720

actgggctgg ctgagcacct gagccctctg atgctgagca cctcttggac taggatcacc      780

ctgtggaaca gggacctggc ccccacccct ggggccaacc tgtatggcag ccaccccttc      840

tatctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa tagcaatgct      900

atggatgtgg tgctgcagcc cagccctgcc ctgtcttgga ggagcactgg gggcatcctg      960

gatgtgtaca ttttcctggg gcctgagccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctacc ccttcatgcc tccctactgg ggcctgggct tccacctgtg caggtggggc     1080

tacagctcta ctgccatcac caggcaggtg gtggagaata tgaccagggc ccacttcccc     1140

ctggatgtgc agtggaatga cctggactac atggactcta ggagggactt caccttcaat     1200

aaggatggct tcagagactt ccctgccatg gtgcaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgccatcagc tcttctggcc ctgctggctc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactgggca gcccctgatt     1380

gggaaggtgt ggcctggctc tactgccttc cctgacttca ccaatcctac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cctttgatgg catgtggatt     1500

gacatgaatg agccctctaa tttcatcagg ggctctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ccctgcaggc tgccaccatc     1620

tgtgctagct ctcaccagtt cctgagcacc cactacaatc tgcataacct gtatggcctg     1680

actgaggcca ttgccagcca cagggccctg gtgaaggcta ggggcaccag gccctttgtg     1740

atttctagga gcacttttgc tggccatggc aggtatgctg ggcactggac tggggatgtg     1800

tggtctagct gggagcagct ggcttcttct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt gggttcctgg gcaacacttc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttc taccctttca tgaggaacca caacagcctg     1980

ctgagcctgc cccaggagcc ctacagcttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc cacctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc taggcctctg ttcctggagt tccccaagga ctctagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgatcactcc tgtgctgcag     2220

gctgggaagg ctgaggtgac tggctatttc cccctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggccctggg gagcctgccc cccccccctg ctgcccccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccctc tggataccat caatgtgcac     2400

ctgagggctg gctacatcat tcccctgcag ggccctggcc tgaccactac tgagtctagg     2460

cagcagccca tggccctggc tgtggccctg accaaggggg gggaggctag gggggagctg     2520

ttttgggatg atggggagag cctggaggtg ctggagaggg gggcctacac tcaggtgatc     2580

ttcctggcca ggaacaatac cattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tatagccctg ataccaaggt gctggatatt     2760

tgtgtgagcc tgctgatggg ggagcagttc ctggtgagct ggtgctga                  2808


<210>  3
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  3
atggctttcc tgtggctgct gtcttgttgg gctctgctgg gcaccacctt tggcctgctg       60

gtgcccaggg agctgtctgg cagcagccct gtgctggagg agacccaccc tgctcatcag      120

cagggggcta gcaggcctgg ccccagggat gcccaggctc accctgggag acccagggct      180

gtgcccactc agtgtgatgt gccccccaac agcaggtttg actgtgctcc tgacaaggct      240

atcacccagg agcagtgtga ggccaggggg tgctgctaca ttcctgctaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc cctcttatcc cagctataag      360

ctggagaacc tgagcagctc tgagatgggc tacactgcca ccctgaccag gaccactccc      420

accttctttc ccaaggatat tctgactctg aggctggatg tgatgatgga gactgagaac      480

aggctgcact tcactatcaa ggaccctgcc aataggaggt atgaggtgcc cctggagact      540

cctcatgtgc atagcagggc cccttctcct ctgtattctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtgc tgctgaacac cactgtggcc      660

cccctgttct ttgctgacca gttcctgcag ctgagcactt ctctgcccag ccagtacatt      720

actgggctgg ctgagcatct gagccccctg atgctgagca cctcttggac caggatcacc      780

ctgtggaaca gggacctggc ccccactcct ggggctaacc tgtatggctc tcaccccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt ttctgctgaa cagcaatgct      900

atggatgtgg tgctgcagcc ctctccagcc ctgtcttgga ggagcactgg gggcattctg      960

gatgtgtaca ttttcctggg gcctgaaccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctacc ccttcatgcc cccctattgg gggctggggt ttcacctgtg caggtggggc     1080

tacagcagca ctgccatcac caggcaggtg gtggagaaca tgaccagggc ccatttcccc     1140

ctggatgtgc agtggaatga cctggactac atggatagca ggagggattt caccttcaac     1200

aaggatggct tcagggactt tcctgccatg gtgcaggagc tgcaccaggg gggcaggagg     1260

tatatgatga ttgtggaccc tgctatcagc agctctggcc ctgctggctc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttt atcactaatg aaactggcca gcctctgatt     1380

ggcaaggtct ggcctggctc tactgccttc cctgatttta ctaaccccac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gatcaggtgc cttttgatgg catgtggatt     1500

gatatgaatg aaccaagcaa cttcatcaga ggctctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ctctgcaggc tgccaccatt     1620

tgtgctagca gccaccagtt cctgagcacc cactacaatc tgcacaacct gtatggcctg     1680

actgaagcca ttgccagcca tagggccctg gtgaaggcca ggggcactag gccttttgtg     1740

atcagcagga gcacttttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggagcagct gggagcagct ggccagctct gtgcctgaga ttctgcagtt taacctgctg     1860

ggggtgcccc tggtgggggc tgatgtgtgt ggcttcctgg gcaacacctc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttt tatcccttca tgaggaacca caacagcctg     1980

ctgagcctgc ctcaggagcc ctactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc cacctgtata ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg ttcctggagt tccccaagga cagcagcacc     2160

tggactgtgg atcatcagct gctgtggggg gaggccctgc tgatcacccc tgtgctgcag     2220

gctggcaagg ctgaggtcac tggctacttc cctctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggctctggg cagcctgccc cccccccctg ctgctcccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgctcccc tggacaccat caatgtgcac     2400

ctgagggctg gctacattat ccccctgcag ggcccagggc tgactaccac tgagagcaga     2460

cagcagccca tggctctggc tgtggccctg accaaggggg gggaagctag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagaggg gggcctatac ccaggtgatc     2580

ttcctggcta ggaacaacac cattgtcaat gagctggtga gggtgacttc tgagggggct     2640

gggctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgctcccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tacagccctg acaccaaggt gctggacatc     2760

tgtgtgtctc tgctgatggg ggagcagttc ctggtgagct ggtgctga                  2808


<210>  4
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  4
atggccttcc tgtggctgct gtcttgctgg gctctgctgg ggaccacctt tggcctgctg       60

gtccccaggg agctgtctgg ctcttctcct gtcctggagg agacccaccc tgcccaccag      120

cagggggcta gcaggcctgg ccccagggat gcccaggccc accctggcag gcccagggct      180

gtgcccaccc agtgtgatgt gcctcccaac agcaggtttg actgtgcccc tgacaaggcc      240

atcacccagg agcagtgtga ggccaggggc tgctgctata tccctgccaa gcagggcctg      300

cagggggctc agatgggcca gccctggtgc ttctttcccc cctcttatcc tagctataag      360

ctggagaacc tgagcagctc tgagatgggg tacactgcca ccctgaccag gaccaccccc      420

actttcttcc ctaaggacat cctgaccctg aggctggatg tgatgatgga gactgagaat      480

aggctgcact ttactatcaa ggaccctgcc aacaggaggt atgaggtgcc tctggagacc      540

ccccatgtgc attctagggc ccccagcccc ctgtactctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag acagctggat ggcagggtcc tgctgaacac cactgtggct      660

cccctgtttt ttgctgacca gttcctgcag ctgagcacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcacct gagccccctg atgctgagca ccagctggac caggatcacc      780

ctgtggaaca gggatctggc tcctacccct ggggccaacc tgtatggctc tcaccccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa cagcaatgct      900

atggatgtgg tgctgcagcc cagccctgcc ctgagctgga ggtctactgg gggcatcctg      960

gatgtgtaca tctttctggg gcctgagccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctatc cttttatgcc cccctattgg ggcctgggct tccacctgtg caggtggggc     1080

tacagcagca ctgccatcac cagacaggtg gtggagaaca tgaccagggc ccacttcccc     1140

ctggatgtgc agtggaatga cctggactac atggacagca ggagggactt cacctttaac     1200

aaggatggct ttagggactt ccctgccatg gtgcaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc agccatcagc agctctgggc ctgctgggtc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactggcca gcccctgatt     1380

ggcaaggtgt ggcctgggag cactgccttc cctgatttta ccaaccccac tgccctggcc     1440

tggtgggagg atatggtggc tgagtttcat gaccaggtgc cctttgatgg catgtggatt     1500

gacatgaatg agcccagcaa tttcatcagg ggctctgagg atggctgccc caacaatgag     1560

ctggagaatc ctccctatgt gcctggggtg gtggggggca ccctgcaggc tgccaccatc     1620

tgtgcctcta gccaccagtt cctgagcacc cactataacc tgcataacct gtatggcctg     1680

actgaggcca ttgccagcca tagagccctg gtgaaggcca gagggaccag gccctttgtg     1740

atctctagga gcacctttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggagctctt gggagcagct ggccagctct gtgccagaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt ggcttcctgg gcaatacctc tgaagagctg     1920

tgtgtgaggt ggactcagct gggggccttc tatcccttca tgaggaacca caacagcctg     1980

ctgtctctgc cccaggagcc ctacagcttc tctgagcctg ctcagcaggc tatgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc catctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg tttctggagt ttcccaagga cagcagcacc     2160

tggactgtgg accatcagct gctgtggggg gaggctctgc tgattacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tgggtacttc cccctgggga cttggtatga cctgcagact     2280

gtgcctgtgg aagctctggg cagcctgccc ccaccccctg ctgcccctag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccctc tggacaccat caatgtgcac     2400

ctgagggctg gctatatcat ccccctgcag ggccctgggc tgaccaccac tgagagcagg     2460

cagcagccca tggccctggc tgtggccctg actaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagagag gggcctacac ccaggtgatc     2580

tttctggcca ggaacaacac cattgtgaat gagctggtga gggtgacttc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgtc taacttcacc tacagccctg atactaaggt gctggatatc     2760

tgtgtgagcc tgctgatggg ggagcagttt ctggtgagct ggtgctga                  2808


<210>  5
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  5
atggcctttc tgtggctgct gtcctgctgg gccctgctgg ggaccacctt tggcctgctg       60

gtgcccaggg agctgtctgg gagcagccca gtgctggagg agacccaccc tgcccaccag      120

cagggggcca gcaggcctgg ccctagggat gcccaggccc accctggcag gcccagggct      180

gtgcctaccc agtgtgatgt gccacccaat tctaggtttg actgtgctcc tgacaaggcc      240

atcactcagg agcagtgtga agctaggggg tgctgctaca tcccagccaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc ccagctaccc tagctacaag      360

ctggagaatc tgagcagctc tgagatgggc tacactgcta ccctgaccag gaccactcct      420

accttcttcc ccaaggacat cctgactctg aggctggatg tcatgatgga gactgaaaat      480

aggctgcact tcaccatcaa ggaccctgcc aataggaggt atgaggtgcc tctggagacc      540

ccccatgtgc atagcagggc tcccagcccc ctgtattctg tggagttctc tgaggagccc      600

tttggggtca ttgtgaggag acagctggat gggagggtgc tgctgaacac tactgtggct      660

cccctgttct ttgctgacca gttcctgcag ctgtctacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcatct gagccccctg atgctgagca ccagctggac caggatcact      780

ctgtggaaca gggatctggc ccccactcct ggggccaacc tgtatgggag ccatcccttc      840

tacctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa cagcaatgcc      900

atggatgtgg tgctgcagcc tagccctgcc ctgagctgga ggagcactgg gggcatcctg      960

gatgtctaca tcttcctggg gcctgagccc aagtctgtgg tgcagcagta tctggatgtg     1020

gtggggtatc ccttcatgcc cccctactgg ggcctgggct ttcacctgtg caggtggggc     1080

tacagcagca ctgccatcac caggcaggtg gtggagaaca tgaccagggc ccacttccct     1140

ctggatgtgc agtggaatga cctggactat atggattcta ggagagactt tacttttaac     1200

aaggatggct tcagggattt ccctgccatg gtgcaggagc tgcaccaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgctattagc agctctggcc ctgctgggtc ttacaggcct     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactggcca gcccctgatt     1380

ggcaaggtgt ggcctggcag cactgccttc cctgacttca ccaaccccac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cctttgatgg gatgtggatt     1500

gacatgaatg agccctctaa cttcatcagg gggtctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ctctgcaggc tgccactatc     1620

tgtgcttctt ctcaccagtt tctgagcacc cactataatc tgcacaacct gtatggcctg     1680

actgaggcca ttgccagcca tagggccctg gtgaaggcca ggggcaccag gccctttgtg     1740

atcagcaggt ctacctttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggtcttctt gggagcagct ggccagctct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt ggctttctgg gcaacacctc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttt taccccttca tgaggaacca caatagcctg     1980

ctgagcctgc cccaggagcc ttactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgactc tgaggtatgc cctgctgccc catctgtata ccctgtttca ccaggcccat     2100

gtggctgggg agactgtggc taggcctctg tttctggagt tccctaagga ctctagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgatcacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tggctacttc cccctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggccctggg gagcctgcct cccccccctg ctgcccccag ggagcctgcc     2340

attcattctg agggccagtg ggtgaccctg cctgcccctc tggacaccat caatgtgcac     2400

ctgagggctg ggtacatcat ccccctgcag ggccctggcc tgaccaccac tgagagcagg     2460

cagcagccca tggccctggc tgtggctctg accaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagtc tctggaggtg ctggagaggg gggcctacac ccaggtgatc     2580

tttctggcca ggaacaatac tattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtcctg     2700

agcaatgggg tgcctgtgag caacttcacc tactctcctg acaccaaggt gctggacatt     2760

tgtgtgtctc tgctgatggg ggagcagttc ctggtgagct ggtgctga                  2808


<210>  6
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  6
atggctttcc tgtggctgct gagctgctgg gctctgctgg gcaccacctt tgggctgctg       60

gtgcctaggg agctgtctgg gtctagccct gtgctggagg agactcaccc tgcccatcag      120

cagggggcta gcaggcctgg ccccagggat gctcaggccc accctggcag gcccagggct      180

gtgcccaccc agtgtgatgt gccccccaac agcaggtttg actgtgcccc tgacaaggcc      240

attacccagg agcagtgtga ggccaggggc tgctgctaca ttccagctaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc ccagctatcc tagctataaa      360

ctggagaacc tgagcagctc tgagatgggc tatactgcca ccctgactag gactactccc      420

accttttttc ctaaggatat cctgaccctg aggctggatg tgatgatgga gactgagaac      480

aggctgcact tcactattaa ggaccctgcc aataggaggt atgaagtgcc tctggagact      540

cctcatgtgc actctagggc ccccagcccc ctgtattctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtgc tgctgaacac cactgtggcc      660

cccctgttct ttgctgacca gttcctgcag ctgagcacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcatct gagccctctg atgctgagca cctcttggac caggatcacc      780

ctgtggaata gggatctggc ccccacccct ggggctaatc tgtatggctc tcatcccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt ttctgctgaa cagcaatgcc      900

atggatgtgg tgctgcagcc ctctcctgcc ctgagctgga ggagcactgg gggcatcctg      960

gatgtgtaca tcttcctggg ccctgagccc aagtctgtgg tccagcagta tctggatgtg     1020

gtgggctacc cctttatgcc cccctattgg ggcctgggct tccacctgtg caggtggggg     1080

tattcttcta ctgctatcac caggcaggtg gtggagaaca tgaccagggc tcacttcccc     1140

ctggatgtgc agtggaatga cctggactat atggactcta ggagggattt caccttcaac     1200

aaggatggct tcagggactt ccctgctatg gtccaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgccatcagc agctctggcc ctgctggcag ctataggccc     1320

tatgatgagg gcctgaggag gggggtgttt atcactaatg aaactgggca gcccctgatt     1380

ggcaaggtgt ggcctggctc tactgccttc cctgacttca ccaaccccac tgctctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cttttgatgg catgtggatt     1500

gacatgaatg agcccagcaa cttcatcagg ggctctgagg atgggtgccc caataatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ccctgcaggc tgccactatt     1620

tgtgccagct ctcaccagtt cctgagcacc cactacaacc tgcacaatct gtatggcctg     1680

actgaggcca ttgccagcca cagggccctg gtgaaggcca ggggcactag gccctttgtg     1740

atctctagaa gcacctttgc tggccatggg aggtatgctg gccactggac tggggatgtg     1800

tggagctctt gggagcagct ggccagctct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcccc tggtgggggc tgatgtgtgt ggcttcctgg gcaacacctc tgaagagctg     1920

tgtgtgaggt ggacccagct gggggccttc taccctttca tgaggaacca caacagcctg     1980

ctgagcctgc ctcaggagcc ttactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc tctgctgccc cacctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg ttcctggagt ttcctaagga tagcagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgattacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tggctacttc cccctgggca cttggtatga cctgcagact     2280

gtgcctgtgg aagccctggg cagcctgcct cccccccctg ctgcccccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccccc tggacaccat taatgtgcat     2400

ctgagggctg ggtatattat ccccctgcag gggcctgggc tgactaccac tgagagcagg     2460

cagcagccta tggccctggc tgtggctctg actaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagaggg gggcctacac ccaggtgatt     2580

ttcctggcca ggaacaacac cattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaagt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tacagccctg acaccaaggt gctggatatt     2760

tgtgtgagcc tgctgatggg ggagcagttc ctggtgagct ggtgctgact cgagagatct     2820

accggtgaat tcaccgcggg tttaaactgt gccttctagt tgccagccat ctgttgtttg     2880

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2940

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     3000

gggggctagc tctaga                                                     3016


<210>  7
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  7
atggctttcc tgtggctgct gtcttgctgg gccctgctgg ggactacctt tggcctgctg       60

gtgcccaggg aactgtctgg ctctagccca gtgctggagg agacccaccc tgcccaccag      120

cagggggctt ctaggcctgg ccccagggat gcccaggccc accctggcag gccaagggct      180

gtgcccaccc agtgtgatgt gccccccaac tctagatttg attgtgcccc tgataaggcc      240

atcacccagg agcagtgtga ggctaggggc tgctgctaca tccctgctaa gcagggcctg      300

cagggggctc agatgggcca gccctggtgc ttcttccccc ccagctatcc ctcttacaag      360

ctggagaatc tgagcagctc tgagatgggc tacactgcca ccctgaccag gactactccc      420

accttcttcc ccaaggacat cctgaccctg aggctggatg tgatgatgga gactgagaac      480

aggctgcatt tcaccatcaa ggatcctgcc aacaggaggt atgaggtgcc tctggagacc      540

ccccatgtgc acagcagggc tccttctccc ctgtactctg tggagttctc tgaggaaccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtcc tgctgaacac cactgtggcc      660

cccctgttct ttgctgatca gttcctgcag ctgtccactt ctctgcctag ccagtacatc      720

actgggctgg ctgagcacct gagccctctg atgctgagca cctcttggac taggatcacc      780

ctgtggaaca gggacctggc ccccacccct ggggccaacc tgtatggcag ccaccccttc      840

tatctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa tagcaatgct      900

atggatgtgg tgctgcagcc cagccctgcc ctgtcttgga ggagcactgg gggcatcctg      960

gatgtgtaca ttttcctggg gcctgagccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctacc ccttcatgcc tccctactgg ggcctgggct tccacctgtg caggtggggc     1080

tacagctcta ctgccatcac caggcaggtg gtggagaata tgaccagggc ccacttcccc     1140

ctggatgtgc agtggaatga cctggactac atggactcta ggagggactt caccttcaat     1200

aaggatggct tcagagactt ccctgccatg gtgcaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgccatcagc tcttctggcc ctgctggctc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactgggca gcccctgatt     1380

gggaaggtgt ggcctggctc tactgccttc cctgacttca ccaatcctac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cctttgatgg catgtggatt     1500

gacatgaatg agccctctaa tttcatcagg ggctctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ccctgcaggc tgccaccatc     1620

tgtgctagct ctcaccagtt cctgagcacc cactacaatc tgcataacct gtatggcctg     1680

actgaggcca ttgccagcca cagggccctg gtgaaggcta ggggcaccag gccctttgtg     1740

atttctagga gcacttttgc tggccatggc aggtatgctg ggcactggac tggggatgtg     1800

tggtctagct gggagcagct ggcttcttct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt gggttcctgg gcaacacttc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttc taccctttca tgaggaacca caacagcctg     1980

ctgagcctgc cccaggagcc ctacagcttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc cacctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc taggcctctg ttcctggagt tccccaagga ctctagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgatcactcc tgtgctgcag     2220

gctgggaagg ctgaggtgac tggctatttc cccctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggccctggg gagcctgccc cccccccctg ctgcccccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccctc tggataccat caatgtgcac     2400

ctgagggctg gctacatcat tcccctgcag ggccctggcc tgaccactac tgagtctagg     2460

cagcagccca tggccctggc tgtggccctg accaaggggg gggaggctag gggggagctg     2520

ttttgggatg atggggagag cctggaggtg ctggagaggg gggcctacac tcaggtgatc     2580

ttcctggcca ggaacaatac cattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tatagccctg ataccaaggt gctggatatt     2760

tgtgtgagcc tgctgatggg ggagcagttc ctggtgagct ggtgctgact cgagagatct     2820

accggtgaat tcaccgcggg tttaaactgt gccttctagt tgccagccat ctgttgtttg     2880

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2940

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     3000

gggggctagc tctaga                                                     3016


<210>  8
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  8
atggctttcc tgtggctgct gtcttgttgg gctctgctgg gcaccacctt tggcctgctg       60

gtgcccaggg agctgtctgg cagcagccct gtgctggagg agacccaccc tgctcatcag      120

cagggggcta gcaggcctgg ccccagggat gcccaggctc accctgggag acccagggct      180

gtgcccactc agtgtgatgt gccccccaac agcaggtttg actgtgctcc tgacaaggct      240

atcacccagg agcagtgtga ggccaggggg tgctgctaca ttcctgctaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc cctcttatcc cagctataag      360

ctggagaacc tgagcagctc tgagatgggc tacactgcca ccctgaccag gaccactccc      420

accttctttc ccaaggatat tctgactctg aggctggatg tgatgatgga gactgagaac      480

aggctgcact tcactatcaa ggaccctgcc aataggaggt atgaggtgcc cctggagact      540

cctcatgtgc atagcagggc cccttctcct ctgtattctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtgc tgctgaacac cactgtggcc      660

cccctgttct ttgctgacca gttcctgcag ctgagcactt ctctgcccag ccagtacatt      720

actgggctgg ctgagcatct gagccccctg atgctgagca cctcttggac caggatcacc      780

ctgtggaaca gggacctggc ccccactcct ggggctaacc tgtatggctc tcaccccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt ttctgctgaa cagcaatgct      900

atggatgtgg tgctgcagcc ctctccagcc ctgtcttgga ggagcactgg gggcattctg      960

gatgtgtaca ttttcctggg gcctgaaccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctacc ccttcatgcc cccctattgg gggctggggt ttcacctgtg caggtggggc     1080

tacagcagca ctgccatcac caggcaggtg gtggagaaca tgaccagggc ccatttcccc     1140

ctggatgtgc agtggaatga cctggactac atggatagca ggagggattt caccttcaac     1200

aaggatggct tcagggactt tcctgccatg gtgcaggagc tgcaccaggg gggcaggagg     1260

tatatgatga ttgtggaccc tgctatcagc agctctggcc ctgctggctc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttt atcactaatg aaactggcca gcctctgatt     1380

ggcaaggtct ggcctggctc tactgccttc cctgatttta ctaaccccac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gatcaggtgc cttttgatgg catgtggatt     1500

gatatgaatg aaccaagcaa cttcatcaga ggctctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ctctgcaggc tgccaccatt     1620

tgtgctagca gccaccagtt cctgagcacc cactacaatc tgcacaacct gtatggcctg     1680

actgaagcca ttgccagcca tagggccctg gtgaaggcca ggggcactag gccttttgtg     1740

atcagcagga gcacttttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggagcagct gggagcagct ggccagctct gtgcctgaga ttctgcagtt taacctgctg     1860

ggggtgcccc tggtgggggc tgatgtgtgt ggcttcctgg gcaacacctc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttt tatcccttca tgaggaacca caacagcctg     1980

ctgagcctgc ctcaggagcc ctactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc cacctgtata ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg ttcctggagt tccccaagga cagcagcacc     2160

tggactgtgg atcatcagct gctgtggggg gaggccctgc tgatcacccc tgtgctgcag     2220

gctggcaagg ctgaggtcac tggctacttc cctctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggctctggg cagcctgccc cccccccctg ctgctcccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgctcccc tggacaccat caatgtgcac     2400

ctgagggctg gctacattat ccccctgcag ggcccagggc tgactaccac tgagagcaga     2460

cagcagccca tggctctggc tgtggccctg accaaggggg gggaagctag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagaggg gggcctatac ccaggtgatc     2580

ttcctggcta ggaacaacac cattgtcaat gagctggtga gggtgacttc tgagggggct     2640

gggctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgctcccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tacagccctg acaccaaggt gctggacatc     2760

tgtgtgtctc tgctgatggg ggagcagttc ctggtgagct ggtgctgact cgagagatct     2820

accggtgaat tcaccgcggg tttaaactgt gccttctagt tgccagccat ctgttgtttg     2880

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2940

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     3000

gggggctagc tctaga                                                     3016


<210>  9
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  9
atggccttcc tgtggctgct gtcttgctgg gctctgctgg ggaccacctt tggcctgctg       60

gtccccaggg agctgtctgg ctcttctcct gtcctggagg agacccaccc tgcccaccag      120

cagggggcta gcaggcctgg ccccagggat gcccaggccc accctggcag gcccagggct      180

gtgcccaccc agtgtgatgt gcctcccaac agcaggtttg actgtgcccc tgacaaggcc      240

atcacccagg agcagtgtga ggccaggggc tgctgctata tccctgccaa gcagggcctg      300

cagggggctc agatgggcca gccctggtgc ttctttcccc cctcttatcc tagctataag      360

ctggagaacc tgagcagctc tgagatgggg tacactgcca ccctgaccag gaccaccccc      420

actttcttcc ctaaggacat cctgaccctg aggctggatg tgatgatgga gactgagaat      480

aggctgcact ttactatcaa ggaccctgcc aacaggaggt atgaggtgcc tctggagacc      540

ccccatgtgc attctagggc ccccagcccc ctgtactctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag acagctggat ggcagggtcc tgctgaacac cactgtggct      660

cccctgtttt ttgctgacca gttcctgcag ctgagcacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcacct gagccccctg atgctgagca ccagctggac caggatcacc      780

ctgtggaaca gggatctggc tcctacccct ggggccaacc tgtatggctc tcaccccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa cagcaatgct      900

atggatgtgg tgctgcagcc cagccctgcc ctgagctgga ggtctactgg gggcatcctg      960

gatgtgtaca tctttctggg gcctgagccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctatc cttttatgcc cccctattgg ggcctgggct tccacctgtg caggtggggc     1080

tacagcagca ctgccatcac cagacaggtg gtggagaaca tgaccagggc ccacttcccc     1140

ctggatgtgc agtggaatga cctggactac atggacagca ggagggactt cacctttaac     1200

aaggatggct ttagggactt ccctgccatg gtgcaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc agccatcagc agctctgggc ctgctgggtc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactggcca gcccctgatt     1380

ggcaaggtgt ggcctgggag cactgccttc cctgatttta ccaaccccac tgccctggcc     1440

tggtgggagg atatggtggc tgagtttcat gaccaggtgc cctttgatgg catgtggatt     1500

gacatgaatg agcccagcaa tttcatcagg ggctctgagg atggctgccc caacaatgag     1560

ctggagaatc ctccctatgt gcctggggtg gtggggggca ccctgcaggc tgccaccatc     1620

tgtgcctcta gccaccagtt cctgagcacc cactataacc tgcataacct gtatggcctg     1680

actgaggcca ttgccagcca tagagccctg gtgaaggcca gagggaccag gccctttgtg     1740

atctctagga gcacctttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggagctctt gggagcagct ggccagctct gtgccagaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt ggcttcctgg gcaatacctc tgaagagctg     1920

tgtgtgaggt ggactcagct gggggccttc tatcccttca tgaggaacca caacagcctg     1980

ctgtctctgc cccaggagcc ctacagcttc tctgagcctg ctcagcaggc tatgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc catctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg tttctggagt ttcccaagga cagcagcacc     2160

tggactgtgg accatcagct gctgtggggg gaggctctgc tgattacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tgggtacttc cccctgggga cttggtatga cctgcagact     2280

gtgcctgtgg aagctctggg cagcctgccc ccaccccctg ctgcccctag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccctc tggacaccat caatgtgcac     2400

ctgagggctg gctatatcat ccccctgcag ggccctgggc tgaccaccac tgagagcagg     2460

cagcagccca tggccctggc tgtggccctg actaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagagag gggcctacac ccaggtgatc     2580

tttctggcca ggaacaacac cattgtgaat gagctggtga gggtgacttc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgtc taacttcacc tacagccctg atactaaggt gctggatatc     2760

tgtgtgagcc tgctgatggg ggagcagttt ctggtgagct ggtgctgact cgagagatct     2820

accggtgaat tcaccgcggg tttaaactgt gccttctagt tgccagccat ctgttgtttg     2880

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2940

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     3000

gggggctagc tctaga                                                     3016


<210>  10
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  10
atggcctttc tgtggctgct gtcctgctgg gccctgctgg ggaccacctt tggcctgctg       60

gtgcccaggg agctgtctgg gagcagccca gtgctggagg agacccaccc tgcccaccag      120

cagggggcca gcaggcctgg ccctagggat gcccaggccc accctggcag gcccagggct      180

gtgcctaccc agtgtgatgt gccacccaat tctaggtttg actgtgctcc tgacaaggcc      240

atcactcagg agcagtgtga agctaggggg tgctgctaca tcccagccaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc ccagctaccc tagctacaag      360

ctggagaatc tgagcagctc tgagatgggc tacactgcta ccctgaccag gaccactcct      420

accttcttcc ccaaggacat cctgactctg aggctggatg tcatgatgga gactgaaaat      480

aggctgcact tcaccatcaa ggaccctgcc aataggaggt atgaggtgcc tctggagacc      540

ccccatgtgc atagcagggc tcccagcccc ctgtattctg tggagttctc tgaggagccc      600

tttggggtca ttgtgaggag acagctggat gggagggtgc tgctgaacac tactgtggct      660

cccctgttct ttgctgacca gttcctgcag ctgtctacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcatct gagccccctg atgctgagca ccagctggac caggatcact      780

ctgtggaaca gggatctggc ccccactcct ggggccaacc tgtatgggag ccatcccttc      840

tacctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa cagcaatgcc      900

atggatgtgg tgctgcagcc tagccctgcc ctgagctgga ggagcactgg gggcatcctg      960

gatgtctaca tcttcctggg gcctgagccc aagtctgtgg tgcagcagta tctggatgtg     1020

gtggggtatc ccttcatgcc cccctactgg ggcctgggct ttcacctgtg caggtggggc     1080

tacagcagca ctgccatcac caggcaggtg gtggagaaca tgaccagggc ccacttccct     1140

ctggatgtgc agtggaatga cctggactat atggattcta ggagagactt tacttttaac     1200

aaggatggct tcagggattt ccctgccatg gtgcaggagc tgcaccaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgctattagc agctctggcc ctgctgggtc ttacaggcct     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactggcca gcccctgatt     1380

ggcaaggtgt ggcctggcag cactgccttc cctgacttca ccaaccccac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cctttgatgg gatgtggatt     1500

gacatgaatg agccctctaa cttcatcagg gggtctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ctctgcaggc tgccactatc     1620

tgtgcttctt ctcaccagtt tctgagcacc cactataatc tgcacaacct gtatggcctg     1680

actgaggcca ttgccagcca tagggccctg gtgaaggcca ggggcaccag gccctttgtg     1740

atcagcaggt ctacctttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggtcttctt gggagcagct ggccagctct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt ggctttctgg gcaacacctc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttt taccccttca tgaggaacca caatagcctg     1980

ctgagcctgc cccaggagcc ttactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgactc tgaggtatgc cctgctgccc catctgtata ccctgtttca ccaggcccat     2100

gtggctgggg agactgtggc taggcctctg tttctggagt tccctaagga ctctagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgatcacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tggctacttc cccctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggccctggg gagcctgcct cccccccctg ctgcccccag ggagcctgcc     2340

attcattctg agggccagtg ggtgaccctg cctgcccctc tggacaccat caatgtgcac     2400

ctgagggctg ggtacatcat ccccctgcag ggccctggcc tgaccaccac tgagagcagg     2460

cagcagccca tggccctggc tgtggctctg accaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagtc tctggaggtg ctggagaggg gggcctacac ccaggtgatc     2580

tttctggcca ggaacaatac tattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtcctg     2700

agcaatgggg tgcctgtgag caacttcacc tactctcctg acaccaaggt gctggacatt     2760

tgtgtgtctc tgctgatggg ggagcagttc ctggtgagct ggtgctgact cgagagatct     2820

accggtgaat tcaccgcggg tttaaactgt gccttctagt tgccagccat ctgttgtttg     2880

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2940

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     3000

gggggctagc tctaga                                                     3016


<210>  11
<211>  3076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  11
atggctttcc tgtggctgct gagctgctgg gctctgctgg gcaccacctt tgggctgctg       60

gtgcctaggg agctgtctgg gtctagccct gtgctggagg agactcaccc tgcccatcag      120

cagggggcta gcaggcctgg ccccagggat gctcaggccc accctggcag gcccagggct      180

gtgcccaccc agtgtgatgt gccccccaac agcaggtttg actgtgcccc tgacaaggcc      240

attacccagg agcagtgtga ggccaggggc tgctgctaca ttccagctaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc ccagctatcc tagctataaa      360

ctggagaacc tgagcagctc tgagatgggc tatactgcca ccctgactag gactactccc      420

accttttttc ctaaggatat cctgaccctg aggctggatg tgatgatgga gactgagaac      480

aggctgcact tcactattaa ggaccctgcc aataggaggt atgaagtgcc tctggagact      540

cctcatgtgc actctagggc ccccagcccc ctgtattctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtgc tgctgaacac cactgtggcc      660

cccctgttct ttgctgacca gttcctgcag ctgagcacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcatct gagccctctg atgctgagca cctcttggac caggatcacc      780

ctgtggaata gggatctggc ccccacccct ggggctaatc tgtatggctc tcatcccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt ttctgctgaa cagcaatgcc      900

atggatgtgg tgctgcagcc ctctcctgcc ctgagctgga ggagcactgg gggcatcctg      960

gatgtgtaca tcttcctggg ccctgagccc aagtctgtgg tccagcagta tctggatgtg     1020

gtgggctacc cctttatgcc cccctattgg ggcctgggct tccacctgtg caggtggggg     1080

tattcttcta ctgctatcac caggcaggtg gtggagaaca tgaccagggc tcacttcccc     1140

ctggatgtgc agtggaatga cctggactat atggactcta ggagggattt caccttcaac     1200

aaggatggct tcagggactt ccctgctatg gtccaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgccatcagc agctctggcc ctgctggcag ctataggccc     1320

tatgatgagg gcctgaggag gggggtgttt atcactaatg aaactgggca gcccctgatt     1380

ggcaaggtgt ggcctggctc tactgccttc cctgacttca ccaaccccac tgctctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cttttgatgg catgtggatt     1500

gacatgaatg agcccagcaa cttcatcagg ggctctgagg atgggtgccc caataatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ccctgcaggc tgccactatt     1620

tgtgccagct ctcaccagtt cctgagcacc cactacaacc tgcacaatct gtatggcctg     1680

actgaggcca ttgccagcca cagggccctg gtgaaggcca ggggcactag gccctttgtg     1740

atctctagaa gcacctttgc tggccatggg aggtatgctg gccactggac tggggatgtg     1800

tggagctctt gggagcagct ggccagctct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcccc tggtgggggc tgatgtgtgt ggcttcctgg gcaacacctc tgaagagctg     1920

tgtgtgaggt ggacccagct gggggccttc taccctttca tgaggaacca caacagcctg     1980

ctgagcctgc ctcaggagcc ttactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc tctgctgccc cacctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg ttcctggagt ttcctaagga tagcagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgattacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tggctacttc cccctgggca cttggtatga cctgcagact     2280

gtgcctgtgg aagccctggg cagcctgcct cccccccctg ctgcccccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccccc tggacaccat taatgtgcat     2400

ctgagggctg ggtatattat ccccctgcag gggcctgggc tgactaccac tgagagcagg     2460

cagcagccta tggccctggc tgtggctctg actaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagaggg gggcctacac ccaggtgatt     2580

ttcctggcca ggaacaacac cattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaagt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tacagccctg acaccaaggt gctggatatt     2760

tgtgtgagcc tgctgatggg ggagcagttc ctggtgagct ggtgctgaag atctagagct     2820

gaattcctgc agccaggggg atcagcctct actgtgcctt ctagttgcca gccatctgtt     2880

gtttgcccct cccccttgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2940

taataaaatg aggaaattgc atcacattgt ctgagtaggt gtcattctat tctggggggt     3000

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3060

gcagtgggct ctatgg                                                     3076


<210>  12
<211>  3076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  12
atggctttcc tgtggctgct gtcttgctgg gccctgctgg ggactacctt tggcctgctg       60

gtgcccaggg aactgtctgg ctctagccca gtgctggagg agacccaccc tgcccaccag      120

cagggggctt ctaggcctgg ccccagggat gcccaggccc accctggcag gccaagggct      180

gtgcccaccc agtgtgatgt gccccccaac tctagatttg attgtgcccc tgataaggcc      240

atcacccagg agcagtgtga ggctaggggc tgctgctaca tccctgctaa gcagggcctg      300

cagggggctc agatgggcca gccctggtgc ttcttccccc ccagctatcc ctcttacaag      360

ctggagaatc tgagcagctc tgagatgggc tacactgcca ccctgaccag gactactccc      420

accttcttcc ccaaggacat cctgaccctg aggctggatg tgatgatgga gactgagaac      480

aggctgcatt tcaccatcaa ggatcctgcc aacaggaggt atgaggtgcc tctggagacc      540

ccccatgtgc acagcagggc tccttctccc ctgtactctg tggagttctc tgaggaaccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtcc tgctgaacac cactgtggcc      660

cccctgttct ttgctgatca gttcctgcag ctgtccactt ctctgcctag ccagtacatc      720

actgggctgg ctgagcacct gagccctctg atgctgagca cctcttggac taggatcacc      780

ctgtggaaca gggacctggc ccccacccct ggggccaacc tgtatggcag ccaccccttc      840

tatctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa tagcaatgct      900

atggatgtgg tgctgcagcc cagccctgcc ctgtcttgga ggagcactgg gggcatcctg      960

gatgtgtaca ttttcctggg gcctgagccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctacc ccttcatgcc tccctactgg ggcctgggct tccacctgtg caggtggggc     1080

tacagctcta ctgccatcac caggcaggtg gtggagaata tgaccagggc ccacttcccc     1140

ctggatgtgc agtggaatga cctggactac atggactcta ggagggactt caccttcaat     1200

aaggatggct tcagagactt ccctgccatg gtgcaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgccatcagc tcttctggcc ctgctggctc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactgggca gcccctgatt     1380

gggaaggtgt ggcctggctc tactgccttc cctgacttca ccaatcctac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cctttgatgg catgtggatt     1500

gacatgaatg agccctctaa tttcatcagg ggctctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ccctgcaggc tgccaccatc     1620

tgtgctagct ctcaccagtt cctgagcacc cactacaatc tgcataacct gtatggcctg     1680

actgaggcca ttgccagcca cagggccctg gtgaaggcta ggggcaccag gccctttgtg     1740

atttctagga gcacttttgc tggccatggc aggtatgctg ggcactggac tggggatgtg     1800

tggtctagct gggagcagct ggcttcttct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt gggttcctgg gcaacacttc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttc taccctttca tgaggaacca caacagcctg     1980

ctgagcctgc cccaggagcc ctacagcttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc cacctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc taggcctctg ttcctggagt tccccaagga ctctagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgatcactcc tgtgctgcag     2220

gctgggaagg ctgaggtgac tggctatttc cccctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggccctggg gagcctgccc cccccccctg ctgcccccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccctc tggataccat caatgtgcac     2400

ctgagggctg gctacatcat tcccctgcag ggccctggcc tgaccactac tgagtctagg     2460

cagcagccca tggccctggc tgtggccctg accaaggggg gggaggctag gggggagctg     2520

ttttgggatg atggggagag cctggaggtg ctggagaggg gggcctacac tcaggtgatc     2580

ttcctggcca ggaacaatac cattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tatagccctg ataccaaggt gctggatatt     2760

tgtgtgagcc tgctgatggg ggagcagttc ctggtgagct ggtgctgaag atctagagct     2820

gaattcctgc agccaggggg atcagcctct actgtgcctt ctagttgcca gccatctgtt     2880

gtttgcccct cccccttgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2940

taataaaatg aggaaattgc atcacattgt ctgagtaggt gtcattctat tctggggggt     3000

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3060

gcagtgggct ctatgg                                                     3076


<210>  13
<211>  3076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  13
atggctttcc tgtggctgct gtcttgttgg gctctgctgg gcaccacctt tggcctgctg       60

gtgcccaggg agctgtctgg cagcagccct gtgctggagg agacccaccc tgctcatcag      120

cagggggcta gcaggcctgg ccccagggat gcccaggctc accctgggag acccagggct      180

gtgcccactc agtgtgatgt gccccccaac agcaggtttg actgtgctcc tgacaaggct      240

atcacccagg agcagtgtga ggccaggggg tgctgctaca ttcctgctaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc cctcttatcc cagctataag      360

ctggagaacc tgagcagctc tgagatgggc tacactgcca ccctgaccag gaccactccc      420

accttctttc ccaaggatat tctgactctg aggctggatg tgatgatgga gactgagaac      480

aggctgcact tcactatcaa ggaccctgcc aataggaggt atgaggtgcc cctggagact      540

cctcatgtgc atagcagggc cccttctcct ctgtattctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag gcagctggat ggcagggtgc tgctgaacac cactgtggcc      660

cccctgttct ttgctgacca gttcctgcag ctgagcactt ctctgcccag ccagtacatt      720

actgggctgg ctgagcatct gagccccctg atgctgagca cctcttggac caggatcacc      780

ctgtggaaca gggacctggc ccccactcct ggggctaacc tgtatggctc tcaccccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt ttctgctgaa cagcaatgct      900

atggatgtgg tgctgcagcc ctctccagcc ctgtcttgga ggagcactgg gggcattctg      960

gatgtgtaca ttttcctggg gcctgaaccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctacc ccttcatgcc cccctattgg gggctggggt ttcacctgtg caggtggggc     1080

tacagcagca ctgccatcac caggcaggtg gtggagaaca tgaccagggc ccatttcccc     1140

ctggatgtgc agtggaatga cctggactac atggatagca ggagggattt caccttcaac     1200

aaggatggct tcagggactt tcctgccatg gtgcaggagc tgcaccaggg gggcaggagg     1260

tatatgatga ttgtggaccc tgctatcagc agctctggcc ctgctggctc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttt atcactaatg aaactggcca gcctctgatt     1380

ggcaaggtct ggcctggctc tactgccttc cctgatttta ctaaccccac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gatcaggtgc cttttgatgg catgtggatt     1500

gatatgaatg aaccaagcaa cttcatcaga ggctctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ctctgcaggc tgccaccatt     1620

tgtgctagca gccaccagtt cctgagcacc cactacaatc tgcacaacct gtatggcctg     1680

actgaagcca ttgccagcca tagggccctg gtgaaggcca ggggcactag gccttttgtg     1740

atcagcagga gcacttttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggagcagct gggagcagct ggccagctct gtgcctgaga ttctgcagtt taacctgctg     1860

ggggtgcccc tggtgggggc tgatgtgtgt ggcttcctgg gcaacacctc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttt tatcccttca tgaggaacca caacagcctg     1980

ctgagcctgc ctcaggagcc ctactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc cacctgtata ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg ttcctggagt tccccaagga cagcagcacc     2160

tggactgtgg atcatcagct gctgtggggg gaggccctgc tgatcacccc tgtgctgcag     2220

gctggcaagg ctgaggtcac tggctacttc cctctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggctctggg cagcctgccc cccccccctg ctgctcccag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgctcccc tggacaccat caatgtgcac     2400

ctgagggctg gctacattat ccccctgcag ggcccagggc tgactaccac tgagagcaga     2460

cagcagccca tggctctggc tgtggccctg accaaggggg gggaagctag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagaggg gggcctatac ccaggtgatc     2580

ttcctggcta ggaacaacac cattgtcaat gagctggtga gggtgacttc tgagggggct     2640

gggctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgctcccca gcaggtgctg     2700

agcaatgggg tgcctgtgag caacttcacc tacagccctg acaccaaggt gctggacatc     2760

tgtgtgtctc tgctgatggg ggagcagttc ctggtgagct ggtgctgaag atctagagct     2820

gaattcctgc agccaggggg atcagcctct actgtgcctt ctagttgcca gccatctgtt     2880

gtttgcccct cccccttgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2940

taataaaatg aggaaattgc atcacattgt ctgagtaggt gtcattctat tctggggggt     3000

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3060

gcagtgggct ctatgg                                                     3076


<210>  14
<211>  3076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  14
atggccttcc tgtggctgct gtcttgctgg gctctgctgg ggaccacctt tggcctgctg       60

gtccccaggg agctgtctgg ctcttctcct gtcctggagg agacccaccc tgcccaccag      120

cagggggcta gcaggcctgg ccccagggat gcccaggccc accctggcag gcccagggct      180

gtgcccaccc agtgtgatgt gcctcccaac agcaggtttg actgtgcccc tgacaaggcc      240

atcacccagg agcagtgtga ggccaggggc tgctgctata tccctgccaa gcagggcctg      300

cagggggctc agatgggcca gccctggtgc ttctttcccc cctcttatcc tagctataag      360

ctggagaacc tgagcagctc tgagatgggg tacactgcca ccctgaccag gaccaccccc      420

actttcttcc ctaaggacat cctgaccctg aggctggatg tgatgatgga gactgagaat      480

aggctgcact ttactatcaa ggaccctgcc aacaggaggt atgaggtgcc tctggagacc      540

ccccatgtgc attctagggc ccccagcccc ctgtactctg tggagttctc tgaggagccc      600

tttggggtga ttgtgaggag acagctggat ggcagggtcc tgctgaacac cactgtggct      660

cccctgtttt ttgctgacca gttcctgcag ctgagcacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcacct gagccccctg atgctgagca ccagctggac caggatcacc      780

ctgtggaaca gggatctggc tcctacccct ggggccaacc tgtatggctc tcaccccttt      840

tacctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa cagcaatgct      900

atggatgtgg tgctgcagcc cagccctgcc ctgagctgga ggtctactgg gggcatcctg      960

gatgtgtaca tctttctggg gcctgagccc aagtctgtgg tgcagcagta cctggatgtg     1020

gtgggctatc cttttatgcc cccctattgg ggcctgggct tccacctgtg caggtggggc     1080

tacagcagca ctgccatcac cagacaggtg gtggagaaca tgaccagggc ccacttcccc     1140

ctggatgtgc agtggaatga cctggactac atggacagca ggagggactt cacctttaac     1200

aaggatggct ttagggactt ccctgccatg gtgcaggagc tgcatcaggg gggcaggagg     1260

tacatgatga ttgtggaccc agccatcagc agctctgggc ctgctgggtc ttacaggccc     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactggcca gcccctgatt     1380

ggcaaggtgt ggcctgggag cactgccttc cctgatttta ccaaccccac tgccctggcc     1440

tggtgggagg atatggtggc tgagtttcat gaccaggtgc cctttgatgg catgtggatt     1500

gacatgaatg agcccagcaa tttcatcagg ggctctgagg atggctgccc caacaatgag     1560

ctggagaatc ctccctatgt gcctggggtg gtggggggca ccctgcaggc tgccaccatc     1620

tgtgcctcta gccaccagtt cctgagcacc cactataacc tgcataacct gtatggcctg     1680

actgaggcca ttgccagcca tagagccctg gtgaaggcca gagggaccag gccctttgtg     1740

atctctagga gcacctttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggagctctt gggagcagct ggccagctct gtgccagaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt ggcttcctgg gcaatacctc tgaagagctg     1920

tgtgtgaggt ggactcagct gggggccttc tatcccttca tgaggaacca caacagcctg     1980

ctgtctctgc cccaggagcc ctacagcttc tctgagcctg ctcagcaggc tatgaggaag     2040

gccctgaccc tgaggtatgc cctgctgccc catctgtaca ccctgttcca ccaggcccat     2100

gtggctgggg agactgtggc caggcccctg tttctggagt ttcccaagga cagcagcacc     2160

tggactgtgg accatcagct gctgtggggg gaggctctgc tgattacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tgggtacttc cccctgggga cttggtatga cctgcagact     2280

gtgcctgtgg aagctctggg cagcctgccc ccaccccctg ctgcccctag ggagcctgcc     2340

atccactctg agggccagtg ggtgaccctg cctgcccctc tggacaccat caatgtgcac     2400

ctgagggctg gctatatcat ccccctgcag ggccctgggc tgaccaccac tgagagcagg     2460

cagcagccca tggccctggc tgtggccctg actaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagag cctggaggtg ctggagagag gggcctacac ccaggtgatc     2580

tttctggcca ggaacaacac cattgtgaat gagctggtga gggtgacttc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtgctg     2700

agcaatgggg tgcctgtgtc taacttcacc tacagccctg atactaaggt gctggatatc     2760

tgtgtgagcc tgctgatggg ggagcagttt ctggtgagct ggtgctgaag atctagagct     2820

gaattcctgc agccaggggg atcagcctct actgtgcctt ctagttgcca gccatctgtt     2880

gtttgcccct cccccttgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2940

taataaaatg aggaaattgc atcacattgt ctgagtaggt gtcattctat tctggggggt     3000

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3060

gcagtgggct ctatgg                                                     3076


<210>  15
<211>  3076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  15
atggcctttc tgtggctgct gtcctgctgg gccctgctgg ggaccacctt tggcctgctg       60

gtgcccaggg agctgtctgg gagcagccca gtgctggagg agacccaccc tgcccaccag      120

cagggggcca gcaggcctgg ccctagggat gcccaggccc accctggcag gcccagggct      180

gtgcctaccc agtgtgatgt gccacccaat tctaggtttg actgtgctcc tgacaaggcc      240

atcactcagg agcagtgtga agctaggggg tgctgctaca tcccagccaa gcagggcctg      300

cagggggccc agatgggcca gccctggtgc ttcttccccc ccagctaccc tagctacaag      360

ctggagaatc tgagcagctc tgagatgggc tacactgcta ccctgaccag gaccactcct      420

accttcttcc ccaaggacat cctgactctg aggctggatg tcatgatgga gactgaaaat      480

aggctgcact tcaccatcaa ggaccctgcc aataggaggt atgaggtgcc tctggagacc      540

ccccatgtgc atagcagggc tcccagcccc ctgtattctg tggagttctc tgaggagccc      600

tttggggtca ttgtgaggag acagctggat gggagggtgc tgctgaacac tactgtggct      660

cccctgttct ttgctgacca gttcctgcag ctgtctacca gcctgcccag ccagtacatc      720

actgggctgg ctgagcatct gagccccctg atgctgagca ccagctggac caggatcact      780

ctgtggaaca gggatctggc ccccactcct ggggccaacc tgtatgggag ccatcccttc      840

tacctggccc tggaggatgg gggctctgcc catggggtgt tcctgctgaa cagcaatgcc      900

atggatgtgg tgctgcagcc tagccctgcc ctgagctgga ggagcactgg gggcatcctg      960

gatgtctaca tcttcctggg gcctgagccc aagtctgtgg tgcagcagta tctggatgtg     1020

gtggggtatc ccttcatgcc cccctactgg ggcctgggct ttcacctgtg caggtggggc     1080

tacagcagca ctgccatcac caggcaggtg gtggagaaca tgaccagggc ccacttccct     1140

ctggatgtgc agtggaatga cctggactat atggattcta ggagagactt tacttttaac     1200

aaggatggct tcagggattt ccctgccatg gtgcaggagc tgcaccaggg gggcaggagg     1260

tacatgatga ttgtggaccc tgctattagc agctctggcc ctgctgggtc ttacaggcct     1320

tatgatgagg gcctgaggag gggggtgttc atcaccaatg agactggcca gcccctgatt     1380

ggcaaggtgt ggcctggcag cactgccttc cctgacttca ccaaccccac tgccctggcc     1440

tggtgggagg acatggtggc tgagttccat gaccaggtgc cctttgatgg gatgtggatt     1500

gacatgaatg agccctctaa cttcatcagg gggtctgagg atggctgccc caacaatgag     1560

ctggagaacc ccccctatgt gcctggggtg gtggggggca ctctgcaggc tgccactatc     1620

tgtgcttctt ctcaccagtt tctgagcacc cactataatc tgcacaacct gtatggcctg     1680

actgaggcca ttgccagcca tagggccctg gtgaaggcca ggggcaccag gccctttgtg     1740

atcagcaggt ctacctttgc tggccatggc aggtatgctg gccactggac tggggatgtg     1800

tggtcttctt gggagcagct ggccagctct gtgcctgaga tcctgcagtt caacctgctg     1860

ggggtgcctc tggtgggggc tgatgtgtgt ggctttctgg gcaacacctc tgaggagctg     1920

tgtgtgaggt ggacccagct gggggccttt taccccttca tgaggaacca caatagcctg     1980

ctgagcctgc cccaggagcc ttactctttc tctgagcctg cccagcaggc catgaggaag     2040

gccctgactc tgaggtatgc cctgctgccc catctgtata ccctgtttca ccaggcccat     2100

gtggctgggg agactgtggc taggcctctg tttctggagt tccctaagga ctctagcacc     2160

tggactgtgg accaccagct gctgtggggg gaggccctgc tgatcacccc tgtgctgcag     2220

gctggcaagg ctgaggtgac tggctacttc cccctgggca cctggtatga cctgcagact     2280

gtgcctgtgg aggccctggg gagcctgcct cccccccctg ctgcccccag ggagcctgcc     2340

attcattctg agggccagtg ggtgaccctg cctgcccctc tggacaccat caatgtgcac     2400

ctgagggctg ggtacatcat ccccctgcag ggccctggcc tgaccaccac tgagagcagg     2460

cagcagccca tggccctggc tgtggctctg accaaggggg gggaggccag gggggagctg     2520

ttctgggatg atggggagtc tctggaggtg ctggagaggg gggcctacac ccaggtgatc     2580

tttctggcca ggaacaatac tattgtgaat gagctggtga gggtgacctc tgagggggct     2640

ggcctgcagc tgcagaaggt gactgtgctg ggggtggcca ctgcccccca gcaggtcctg     2700

agcaatgggg tgcctgtgag caacttcacc tactctcctg acaccaaggt gctggacatt     2760

tgtgtgtctc tgctgatggg ggagcagttc ctggtgagct ggtgctgaag atctagagct     2820

gaattcctgc agccaggggg atcagcctct actgtgcctt ctagttgcca gccatctgtt     2880

gtttgcccct cccccttgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2940

taataaaatg aggaaattgc atcacattgt ctgagtaggt gtcattctat tctggggggt     3000

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3060

gcagtgggct ctatgg                                                     3076


<210>  16
<211>  4730
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  16
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctag taggctcaga ggcacacagg agtttctggg      180

ctcaccctgc ccccttccaa cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc      240

ctctgaagtc cacactgaac aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt      300

gcaagcagca aacagcaaac acacagccct ccctgcctgc tgaccttgga gctggggcag      360

aggtcagaga cctctctggg cccatgccac ctccaacatc cactcgaccc cttggaattt      420

cggtggagag gagcagaggt tgtcctggcg tggtttaggt agtgtgagag gggtacccgg      480

ggatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct      540

aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga      600

cgctgtggtt tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac      660

actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac      720

ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc      780

tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc      840

tcagcttcag gcaccaccac tgacctggga cagtgaatac cactttcaca atctgctagc      900

gtttaaacga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      960

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat     1020

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat     1080

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat     1140

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1200

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1260

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1320

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1380

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1440

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgtcctg ctgggccctg     1500

ctggggacca cctttggcct gctggtgccc agggagctgt ctgggagcag cccagtgctg     1560

gaggagaccc accctgccca ccagcagggg gccagcaggc ctggccctag ggatgcccag     1620

gcccaccctg gcaggcccag ggctgtgcct acccagtgtg atgtgccacc caattctagg     1680

tttgactgtg ctcctgacaa ggccatcact caggagcagt gtgaagctag ggggtgctgc     1740

tacatcccag ccaagcaggg cctgcagggg gcccagatgg gccagccctg gtgcttcttc     1800

ccccccagct accctagcta caagctggag aatctgagca gctctgagat gggctacact     1860

gctaccctga ccaggaccac tcctaccttc ttccccaagg acatcctgac tctgaggctg     1920

gatgtcatga tggagactga aaataggctg cacttcacca tcaaggaccc tgccaatagg     1980

aggtatgagg tgcctctgga gaccccccat gtgcatagca gggctcccag ccccctgtat     2040

tctgtggagt tctctgagga gccctttggg gtcattgtga ggagacagct ggatgggagg     2100

gtgctgctga acactactgt ggctcccctg ttctttgctg accagttcct gcagctgtct     2160

accagcctgc ccagccagta catcactggg ctggctgagc atctgagccc cctgatgctg     2220

agcaccagct ggaccaggat cactctgtgg aacagggatc tggcccccac tcctggggcc     2280

aacctgtatg ggagccatcc cttctacctg gccctggagg atgggggctc tgcccatggg     2340

gtgttcctgc tgaacagcaa tgccatggat gtggtgctgc agcctagccc tgccctgagc     2400

tggaggagca ctgggggcat cctggatgtc tacatcttcc tggggcctga gcccaagtct     2460

gtggtgcagc agtatctgga tgtggtgggg tatcccttca tgccccccta ctggggcctg     2520

ggctttcacc tgtgcaggtg gggctacagc agcactgcca tcaccaggca ggtggtggag     2580

aacatgacca gggcccactt ccctctggat gtgcagtgga atgacctgga ctatatggat     2640

tctaggagag actttacttt taacaaggat ggcttcaggg atttccctgc catggtgcag     2700

gagctgcacc aggggggcag gaggtacatg atgattgtgg accctgctat tagcagctct     2760

ggccctgctg ggtcttacag gccttatgat gagggcctga ggaggggggt gttcatcacc     2820

aatgagactg gccagcccct gattggcaag gtgtggcctg gcagcactgc cttccctgac     2880

ttcaccaacc ccactgccct ggcctggtgg gaggacatgg tggctgagtt ccatgaccag     2940

gtgccctttg atgggatgtg gattgacatg aatgagccct ctaacttcat cagggggtct     3000

gaggatggct gccccaacaa tgagctggag aaccccccct atgtgcctgg ggtggtgggg     3060

ggcactctgc aggctgccac tatctgtgct tcttctcacc agtttctgag cacccactat     3120

aatctgcaca acctgtatgg cctgactgag gccattgcca gccatagggc cctggtgaag     3180

gccaggggca ccaggccctt tgtgatcagc aggtctacct ttgctggcca tggcaggtat     3240

gctggccact ggactgggga tgtgtggtct tcttgggagc agctggccag ctctgtgcct     3300

gagatcctgc agttcaacct gctgggggtg cctctggtgg gggctgatgt gtgtggcttt     3360

ctgggcaaca cctctgagga gctgtgtgtg aggtggaccc agctgggggc cttttacccc     3420

ttcatgagga accacaatag cctgctgagc ctgccccagg agccttactc tttctctgag     3480

cctgcccagc aggccatgag gaaggccctg actctgaggt atgccctgct gccccatctg     3540

tataccctgt ttcaccaggc ccatgtggct ggggagactg tggctaggcc tctgtttctg     3600

gagttcccta aggactctag cacctggact gtggaccacc agctgctgtg gggggaggcc     3660

ctgctgatca cccctgtgct gcaggctggc aaggctgagg tgactggcta cttccccctg     3720

ggcacctggt atgacctgca gactgtgcct gtggaggccc tggggagcct gcctcccccc     3780

cctgctgccc ccagggagcc tgccattcat tctgagggcc agtgggtgac cctgcctgcc     3840

cctctggaca ccatcaatgt gcacctgagg gctgggtaca tcatccccct gcagggccct     3900

ggcctgacca ccactgagag caggcagcag cccatggccc tggctgtggc tctgaccaag     3960

gggggggagg ccagggggga gctgttctgg gatgatgggg agtctctgga ggtgctggag     4020

aggggggcct acacccaggt gatctttctg gccaggaaca atactattgt gaatgagctg     4080

gtgagggtga cctctgaggg ggctggcctg cagctgcaga aggtgactgt gctgggggtg     4140

gccactgccc cccagcaggt cctgagcaat ggggtgcctg tgagcaactt cacctactct     4200

cctgacacca aggtgctgga catttgtgtg tctctgctga tgggggagca gttcctggtg     4260

agctggtgct gaagatctag agctgaattc ctgcagccag ggggatcagc ctctactgtg     4320

ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt gaccctggaa     4380

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca ttgtctgagt     4440

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     4500

gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc agaaagaacc     4560

agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt tggccactcc     4620

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4680

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg                4730


<210>  17
<211>  4701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  17
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctag taggctcaga ggcacacagg agtttctggg      180

ctcaccctgc ccccttccaa cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc      240

ctctgaagtc cacactgaac aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt      300

gcaagcagca aacagcaaac acacagccct ccctgcctgc tgaccttgga gctggggcag      360

aggtcagaga cctctctggg cccatgccac ctccaacatc cactcgaccc cttggaattt      420

cggtggagag gagcagaggt tgtcctggcg tggtttaggt agtgtgagag gggtacccgg      480

ggatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct      540

aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga      600

cgctgtggtt tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac      660

actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac      720

ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc      780

tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc      840

tcagcttcag gcaccaccac tgacctggga cagtgaatag atcctgagaa cttcagggtg      900

agtctatggg acccttgatg ttttctttcc ccttcttttc tatggttaag ttcatgtcat      960

aggaagggga gaagtaacag ggtacacata ttgaccaaat cagggtaatt ttgcatttgt     1020

aattttaaaa aatgctttct tcttttaata tacttttttg tttatcttat ttctaatact     1080

ttccctaatc tctttctttc agggcaataa tgatacaatg tatcatgcct ctttgcacca     1140

ttctaaagaa taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa     1200

atatttctgc atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac     1260

aatccagcta ccattctgct tttattttct ggttgggata aggctggatt attctgagtc     1320

caagctaggc ccttttgcta atcttgttca tacctcttat cttcctccca cagctcctgg     1380

gcaacctgct ggtctctctg ctggcccatc actttggcaa agcacgcgtg ccaccatggc     1440

ctttctgtgg ctgctgtcct gctgggccct gctggggacc acctttggcc tgctggtgcc     1500

cagggagctg tctgggagca gcccagtgct ggaggagacc caccctgccc accagcaggg     1560

ggccagcagg cctggcccta gggatgccca ggcccaccct ggcaggccca gggctgtgcc     1620

tacccagtgt gatgtgccac ccaattctag gtttgactgt gctcctgaca aggccatcac     1680

tcaggagcag tgtgaagcta gggggtgctg ctacatccca gccaagcagg gcctgcaggg     1740

ggcccagatg ggccagccct ggtgcttctt cccccccagc taccctagct acaagctgga     1800

gaatctgagc agctctgaga tgggctacac tgctaccctg accaggacca ctcctacctt     1860

cttccccaag gacatcctga ctctgaggct ggatgtcatg atggagactg aaaataggct     1920

gcacttcacc atcaaggacc ctgccaatag gaggtatgag gtgcctctgg agacccccca     1980

tgtgcatagc agggctccca gccccctgta ttctgtggag ttctctgagg agccctttgg     2040

ggtcattgtg aggagacagc tggatgggag ggtgctgctg aacactactg tggctcccct     2100

gttctttgct gaccagttcc tgcagctgtc taccagcctg cccagccagt acatcactgg     2160

gctggctgag catctgagcc ccctgatgct gagcaccagc tggaccagga tcactctgtg     2220

gaacagggat ctggccccca ctcctggggc caacctgtat gggagccatc ccttctacct     2280

ggccctggag gatgggggct ctgcccatgg ggtgttcctg ctgaacagca atgccatgga     2340

tgtggtgctg cagcctagcc ctgccctgag ctggaggagc actgggggca tcctggatgt     2400

ctacatcttc ctggggcctg agcccaagtc tgtggtgcag cagtatctgg atgtggtggg     2460

gtatcccttc atgcccccct actggggcct gggctttcac ctgtgcaggt ggggctacag     2520

cagcactgcc atcaccaggc aggtggtgga gaacatgacc agggcccact tccctctgga     2580

tgtgcagtgg aatgacctgg actatatgga ttctaggaga gactttactt ttaacaagga     2640

tggcttcagg gatttccctg ccatggtgca ggagctgcac caggggggca ggaggtacat     2700

gatgattgtg gaccctgcta ttagcagctc tggccctgct gggtcttaca ggccttatga     2760

tgagggcctg aggagggggg tgttcatcac caatgagact ggccagcccc tgattggcaa     2820

ggtgtggcct ggcagcactg ccttccctga cttcaccaac cccactgccc tggcctggtg     2880

ggaggacatg gtggctgagt tccatgacca ggtgcccttt gatgggatgt ggattgacat     2940

gaatgagccc tctaacttca tcagggggtc tgaggatggc tgccccaaca atgagctgga     3000

gaaccccccc tatgtgcctg gggtggtggg gggcactctg caggctgcca ctatctgtgc     3060

ttcttctcac cagtttctga gcacccacta taatctgcac aacctgtatg gcctgactga     3120

ggccattgcc agccataggg ccctggtgaa ggccaggggc accaggccct ttgtgatcag     3180

caggtctacc tttgctggcc atggcaggta tgctggccac tggactgggg atgtgtggtc     3240

ttcttgggag cagctggcca gctctgtgcc tgagatcctg cagttcaacc tgctgggggt     3300

gcctctggtg ggggctgatg tgtgtggctt tctgggcaac acctctgagg agctgtgtgt     3360

gaggtggacc cagctggggg ccttttaccc cttcatgagg aaccacaata gcctgctgag     3420

cctgccccag gagccttact ctttctctga gcctgcccag caggccatga ggaaggccct     3480

gactctgagg tatgccctgc tgccccatct gtataccctg tttcaccagg cccatgtggc     3540

tggggagact gtggctaggc ctctgtttct ggagttccct aaggactcta gcacctggac     3600

tgtggaccac cagctgctgt ggggggaggc cctgctgatc acccctgtgc tgcaggctgg     3660

caaggctgag gtgactggct acttccccct gggcacctgg tatgacctgc agactgtgcc     3720

tgtggaggcc ctggggagcc tgcctccccc ccctgctgcc cccagggagc ctgccattca     3780

ttctgagggc cagtgggtga ccctgcctgc ccctctggac accatcaatg tgcacctgag     3840

ggctgggtac atcatccccc tgcagggccc tggcctgacc accactgaga gcaggcagca     3900

gcccatggcc ctggctgtgg ctctgaccaa ggggggggag gccagggggg agctgttctg     3960

ggatgatggg gagtctctgg aggtgctgga gaggggggcc tacacccagg tgatctttct     4020

ggccaggaac aatactattg tgaatgagct ggtgagggtg acctctgagg gggctggcct     4080

gcagctgcag aaggtgactg tgctgggggt ggccactgcc ccccagcagg tcctgagcaa     4140

tggggtgcct gtgagcaact tcacctactc tcctgacacc aaggtgctgg acatttgtgt     4200

gtctctgctg atgggggagc agttcctggt gagctggtgc tgaagatcta gagctgaatt     4260

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     4320

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     4380

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     4440

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     4500

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     4560

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     4620

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4680

gagcgcgcag ctgcctgcag g                                               4701


<210>  18
<211>  4701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  18
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctag taggctcaga ggcacacagg agtttctggg      180

ctcaccctgc ccccttccaa cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc      240

ctctgaagtc cacactgaac aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt      300

gcaagcagca aacagcaaac acacagccct ccctgcctgc tgaccttgga gctggggcag      360

aggtcagaga cctctctggg cccatgccac ctccaacatc cactcgaccc cttggaattt      420

cggtggagag gagcagaggt tgtcctggcg tggtttaggt agtgtgagag gggtacccgg      480

ggatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct      540

aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga      600

cgctgtggtt tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac      660

actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac      720

ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc      780

tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc      840

tcagcttcag gcaccaccac tgacctggga cagtgaatag atcctgagaa cttcagggtg      900

agtctatggg acccttgatg ttttctttcc ccttcttttc tatggttaag ttcatgtcat      960

aggaagggga gaagtaacag ggtacacata ttgaccaaat cagggtaatt ttgcatttgt     1020

aattttaaaa aatgctttct tcttttaata tacttttttg tttatcttat ttctaatact     1080

ttccctaatc tctttctttc agggcaataa tgatacaatg tatcatgcct ctttgcacca     1140

ttctaaagaa taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa     1200

atatttctgc atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac     1260

aatccagcta ccattctgct tttattttct ggttgggata aggctggatt attctgagtc     1320

caagctaggc ccttttgcta atcttgttca tacctcttat cttcctccca cagctcctgg     1380

gcaacctgct ggtctctctg ctggcccatc actttggcaa agcacgcgtg ccaccatggc     1440

tttcctgtgg ctgctgtctt gttgggctct gctgggcacc acctttggcc tgctggtgcc     1500

cagggagctg tctggcagca gccctgtgct ggaggagacc caccctgctc atcagcaggg     1560

ggctagcagg cctggcccca gggatgccca ggctcaccct gggagaccca gggctgtgcc     1620

cactcagtgt gatgtgcccc ccaacagcag gtttgactgt gctcctgaca aggctatcac     1680

ccaggagcag tgtgaggcca gggggtgctg ctacattcct gctaagcagg gcctgcaggg     1740

ggcccagatg ggccagccct ggtgcttctt ccccccctct tatcccagct ataagctgga     1800

gaacctgagc agctctgaga tgggctacac tgccaccctg accaggacca ctcccacctt     1860

ctttcccaag gatattctga ctctgaggct ggatgtgatg atggagactg agaacaggct     1920

gcacttcact atcaaggacc ctgccaatag gaggtatgag gtgcccctgg agactcctca     1980

tgtgcatagc agggcccctt ctcctctgta ttctgtggag ttctctgagg agccctttgg     2040

ggtgattgtg aggaggcagc tggatggcag ggtgctgctg aacaccactg tggcccccct     2100

gttctttgct gaccagttcc tgcagctgag cacttctctg cccagccagt acattactgg     2160

gctggctgag catctgagcc ccctgatgct gagcacctct tggaccagga tcaccctgtg     2220

gaacagggac ctggccccca ctcctggggc taacctgtat ggctctcacc ccttttacct     2280

ggccctggag gatgggggct ctgcccatgg ggtgtttctg ctgaacagca atgctatgga     2340

tgtggtgctg cagccctctc cagccctgtc ttggaggagc actgggggca ttctggatgt     2400

gtacattttc ctggggcctg aacccaagtc tgtggtgcag cagtacctgg atgtggtggg     2460

ctaccccttc atgcccccct attgggggct ggggtttcac ctgtgcaggt ggggctacag     2520

cagcactgcc atcaccaggc aggtggtgga gaacatgacc agggcccatt tccccctgga     2580

tgtgcagtgg aatgacctgg actacatgga tagcaggagg gatttcacct tcaacaagga     2640

tggcttcagg gactttcctg ccatggtgca ggagctgcac caggggggca ggaggtatat     2700

gatgattgtg gaccctgcta tcagcagctc tggccctgct ggctcttaca ggccctatga     2760

tgagggcctg aggagggggg tgtttatcac taatgaaact ggccagcctc tgattggcaa     2820

ggtctggcct ggctctactg ccttccctga ttttactaac cccactgccc tggcctggtg     2880

ggaggacatg gtggctgagt tccatgatca ggtgcctttt gatggcatgt ggattgatat     2940

gaatgaacca agcaacttca tcagaggctc tgaggatggc tgccccaaca atgagctgga     3000

gaaccccccc tatgtgcctg gggtggtggg gggcactctg caggctgcca ccatttgtgc     3060

tagcagccac cagttcctga gcacccacta caatctgcac aacctgtatg gcctgactga     3120

agccattgcc agccataggg ccctggtgaa ggccaggggc actaggcctt ttgtgatcag     3180

caggagcact tttgctggcc atggcaggta tgctggccac tggactgggg atgtgtggag     3240

cagctgggag cagctggcca gctctgtgcc tgagattctg cagtttaacc tgctgggggt     3300

gcccctggtg ggggctgatg tgtgtggctt cctgggcaac acctctgagg agctgtgtgt     3360

gaggtggacc cagctggggg ccttttatcc cttcatgagg aaccacaaca gcctgctgag     3420

cctgcctcag gagccctact ctttctctga gcctgcccag caggccatga ggaaggccct     3480

gaccctgagg tatgccctgc tgccccacct gtataccctg ttccaccagg cccatgtggc     3540

tggggagact gtggccaggc ccctgttcct ggagttcccc aaggacagca gcacctggac     3600

tgtggatcat cagctgctgt ggggggaggc cctgctgatc acccctgtgc tgcaggctgg     3660

caaggctgag gtcactggct acttccctct gggcacctgg tatgacctgc agactgtgcc     3720

tgtggaggct ctgggcagcc tgcccccccc ccctgctgct cccagggagc ctgccatcca     3780

ctctgagggc cagtgggtga ccctgcctgc tcccctggac accatcaatg tgcacctgag     3840

ggctggctac attatccccc tgcagggccc agggctgact accactgaga gcagacagca     3900

gcccatggct ctggctgtgg ccctgaccaa ggggggggaa gctagggggg agctgttctg     3960

ggatgatggg gagagcctgg aggtgctgga gaggggggcc tatacccagg tgatcttcct     4020

ggctaggaac aacaccattg tcaatgagct ggtgagggtg acttctgagg gggctgggct     4080

gcagctgcag aaggtgactg tgctgggggt ggccactgct ccccagcagg tgctgagcaa     4140

tggggtgcct gtgagcaact tcacctacag ccctgacacc aaggtgctgg acatctgtgt     4200

gtctctgctg atgggggagc agttcctggt gagctggtgc tgaagatcta gagctgaatt     4260

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     4320

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     4380

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     4440

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     4500

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     4560

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     4620

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4680

gagcgcgcag ctgcctgcag g                                               4701


<210>  19
<211>  4701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  19
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctag taggctcaga ggcacacagg agtttctggg      180

ctcaccctgc ccccttccaa cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc      240

ctctgaagtc cacactgaac aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt      300

gcaagcagca aacagcaaac acacagccct ccctgcctgc tgaccttgga gctggggcag      360

aggtcagaga cctctctggg cccatgccac ctccaacatc cactcgaccc cttggaattt      420

cggtggagag gagcagaggt tgtcctggcg tggtttaggt agtgtgagag gggtacccgg      480

ggatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct      540

aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga      600

cgctgtggtt tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac      660

actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac      720

ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc      780

tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc      840

tcagcttcag gcaccaccac tgacctggga cagtgaatag atcctgagaa cttcagggtg      900

agtctatggg acccttgatg ttttctttcc ccttcttttc tatggttaag ttcatgtcat      960

aggaagggga gaagtaacag ggtacacata ttgaccaaat cagggtaatt ttgcatttgt     1020

aattttaaaa aatgctttct tcttttaata tacttttttg tttatcttat ttctaatact     1080

ttccctaatc tctttctttc agggcaataa tgatacaatg tatcatgcct ctttgcacca     1140

ttctaaagaa taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa     1200

atatttctgc atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac     1260

aatccagcta ccattctgct tttattttct ggttgggata aggctggatt attctgagtc     1320

caagctaggc ccttttgcta atcttgttca tacctcttat cttcctccca cagctcctgg     1380

gcaacctgct ggtctctctg ctggcccatc actttggcaa agcacgcgtg ccaccatggc     1440

cttcctgtgg ctgctgtctt gctgggctct gctggggacc acctttggcc tgctggtccc     1500

cagggagctg tctggctctt ctcctgtcct ggaggagacc caccctgccc accagcaggg     1560

ggctagcagg cctggcccca gggatgccca ggcccaccct ggcaggccca gggctgtgcc     1620

cacccagtgt gatgtgcctc ccaacagcag gtttgactgt gcccctgaca aggccatcac     1680

ccaggagcag tgtgaggcca ggggctgctg ctatatccct gccaagcagg gcctgcaggg     1740

ggctcagatg ggccagccct ggtgcttctt tcccccctct tatcctagct ataagctgga     1800

gaacctgagc agctctgaga tggggtacac tgccaccctg accaggacca cccccacttt     1860

cttccctaag gacatcctga ccctgaggct ggatgtgatg atggagactg agaataggct     1920

gcactttact atcaaggacc ctgccaacag gaggtatgag gtgcctctgg agacccccca     1980

tgtgcattct agggccccca gccccctgta ctctgtggag ttctctgagg agccctttgg     2040

ggtgattgtg aggagacagc tggatggcag ggtcctgctg aacaccactg tggctcccct     2100

gttttttgct gaccagttcc tgcagctgag caccagcctg cccagccagt acatcactgg     2160

gctggctgag cacctgagcc ccctgatgct gagcaccagc tggaccagga tcaccctgtg     2220

gaacagggat ctggctccta cccctggggc caacctgtat ggctctcacc ccttttacct     2280

ggccctggag gatgggggct ctgcccatgg ggtgttcctg ctgaacagca atgctatgga     2340

tgtggtgctg cagcccagcc ctgccctgag ctggaggtct actgggggca tcctggatgt     2400

gtacatcttt ctggggcctg agcccaagtc tgtggtgcag cagtacctgg atgtggtggg     2460

ctatcctttt atgcccccct attggggcct gggcttccac ctgtgcaggt ggggctacag     2520

cagcactgcc atcaccagac aggtggtgga gaacatgacc agggcccact tccccctgga     2580

tgtgcagtgg aatgacctgg actacatgga cagcaggagg gacttcacct ttaacaagga     2640

tggctttagg gacttccctg ccatggtgca ggagctgcat caggggggca ggaggtacat     2700

gatgattgtg gacccagcca tcagcagctc tgggcctgct gggtcttaca ggccctatga     2760

tgagggcctg aggagggggg tgttcatcac caatgagact ggccagcccc tgattggcaa     2820

ggtgtggcct gggagcactg ccttccctga ttttaccaac cccactgccc tggcctggtg     2880

ggaggatatg gtggctgagt ttcatgacca ggtgcccttt gatggcatgt ggattgacat     2940

gaatgagccc agcaatttca tcaggggctc tgaggatggc tgccccaaca atgagctgga     3000

gaatcctccc tatgtgcctg gggtggtggg gggcaccctg caggctgcca ccatctgtgc     3060

ctctagccac cagttcctga gcacccacta taacctgcat aacctgtatg gcctgactga     3120

ggccattgcc agccatagag ccctggtgaa ggccagaggg accaggccct ttgtgatctc     3180

taggagcacc tttgctggcc atggcaggta tgctggccac tggactgggg atgtgtggag     3240

ctcttgggag cagctggcca gctctgtgcc agagatcctg cagttcaacc tgctgggggt     3300

gcctctggtg ggggctgatg tgtgtggctt cctgggcaat acctctgaag agctgtgtgt     3360

gaggtggact cagctggggg ccttctatcc cttcatgagg aaccacaaca gcctgctgtc     3420

tctgccccag gagccctaca gcttctctga gcctgctcag caggctatga ggaaggccct     3480

gaccctgagg tatgccctgc tgccccatct gtacaccctg ttccaccagg cccatgtggc     3540

tggggagact gtggccaggc ccctgtttct ggagtttccc aaggacagca gcacctggac     3600

tgtggaccat cagctgctgt ggggggaggc tctgctgatt acccctgtgc tgcaggctgg     3660

caaggctgag gtgactgggt acttccccct ggggacttgg tatgacctgc agactgtgcc     3720

tgtggaagct ctgggcagcc tgcccccacc ccctgctgcc cctagggagc ctgccatcca     3780

ctctgagggc cagtgggtga ccctgcctgc ccctctggac accatcaatg tgcacctgag     3840

ggctggctat atcatccccc tgcagggccc tgggctgacc accactgaga gcaggcagca     3900

gcccatggcc ctggctgtgg ccctgactaa ggggggggag gccagggggg agctgttctg     3960

ggatgatggg gagagcctgg aggtgctgga gagaggggcc tacacccagg tgatctttct     4020

ggccaggaac aacaccattg tgaatgagct ggtgagggtg acttctgagg gggctggcct     4080

gcagctgcag aaggtgactg tgctgggggt ggccactgcc ccccagcagg tgctgagcaa     4140

tggggtgcct gtgtctaact tcacctacag ccctgatact aaggtgctgg atatctgtgt     4200

gagcctgctg atgggggagc agtttctggt gagctggtgc tgaagatcta gagctgaatt     4260

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     4320

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     4380

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     4440

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     4500

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     4560

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     4620

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4680

gagcgcgcag ctgcctgcag g                                               4701


<210>  20
<211>  4611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  20
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca ggctcagagg cacacaggag tttctgggct      180

caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg tgtgctgcct      240

ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg caaacattgc      300

aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag      360

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg      420

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gtacccgggg      480

atcttgctac cagtggaaca gccactaagg attctgcagt gagagcagag ggccagctaa      540

gtggtactct cccagagact gtctgactca cgccaccccc tccaccttgg acacaggacg      600

ctgtggtttc tgagccaggt acaatgactc ctttcggtaa gtgcagtgga agctgtacac      660

tgcccaggca aagcgtccgg gcagcgtagg cgggcgactc agatcccagc cagtggactt      720

agcccctgtt tgctcctccg ataactgggg tgaccttggt taatattcac cagcagcctc      780

ccccgttgcc cctctggatc cactgcttaa atacggacga ggacagggcc ctgtctcctc      840

agcttcaggc accaccactg acctgggaca gtgaatagat cctgagaact tcagggtgag      900

tctatgggac ccttgatgtt ttctttcccc ttcttttcta tggttaagtt catgtcatag      960

gaaggggaga agtaacaggg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1020

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1080

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1140

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1200

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1260

tccagctacc attctgcttt tattttctgg ttgggataag gctggattat tctgagtcca     1320

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     1380

aacctgctgg tctctctgct ggcccatcac tttggcaaag cacgcgtgcc accatggctt     1440

tcctgtggct gctgagctgc tgggctctgc tgggcaccac ctttgggctg ctggtgccta     1500

gggagctgtc tgggtctagc cctgtgctgg aggagactca ccctgcccat cagcaggggg     1560

ctagcaggcc tggccccagg gatgctcagg cccaccctgg caggcccagg gctgtgccca     1620

cccagtgtga tgtgcccccc aacagcaggt ttgactgtgc ccctgacaag gccattaccc     1680

aggagcagtg tgaggccagg ggctgctgct acattccagc taagcagggc ctgcaggggg     1740

cccagatggg ccagccctgg tgcttcttcc cccccagcta tcctagctat aaactggaga     1800

acctgagcag ctctgagatg ggctatactg ccaccctgac taggactact cccacctttt     1860

ttcctaagga tatcctgacc ctgaggctgg atgtgatgat ggagactgag aacaggctgc     1920

acttcactat taaggaccct gccaatagga ggtatgaagt gcctctggag actcctcatg     1980

tgcactctag ggcccccagc cccctgtatt ctgtggagtt ctctgaggag ccctttgggg     2040

tgattgtgag gaggcagctg gatggcaggg tgctgctgaa caccactgtg gcccccctgt     2100

tctttgctga ccagttcctg cagctgagca ccagcctgcc cagccagtac atcactgggc     2160

tggctgagca tctgagccct ctgatgctga gcacctcttg gaccaggatc accctgtgga     2220

atagggatct ggcccccacc cctggggcta atctgtatgg ctctcatccc ttttacctgg     2280

ccctggagga tgggggctct gcccatgggg tgtttctgct gaacagcaat gccatggatg     2340

tggtgctgca gccctctcct gccctgagct ggaggagcac tgggggcatc ctggatgtgt     2400

acatcttcct gggccctgag cccaagtctg tggtccagca gtatctggat gtggtgggct     2460

acccctttat gcccccctat tggggcctgg gcttccacct gtgcaggtgg gggtattctt     2520

ctactgctat caccaggcag gtggtggaga acatgaccag ggctcacttc cccctggatg     2580

tgcagtggaa tgacctggac tatatggact ctaggaggga tttcaccttc aacaaggatg     2640

gcttcaggga cttccctgct atggtccagg agctgcatca ggggggcagg aggtacatga     2700

tgattgtgga ccctgccatc agcagctctg gccctgctgg cagctatagg ccctatgatg     2760

agggcctgag gaggggggtg tttatcacta atgaaactgg gcagcccctg attggcaagg     2820

tgtggcctgg ctctactgcc ttccctgact tcaccaaccc cactgctctg gcctggtggg     2880

aggacatggt ggctgagttc catgaccagg tgccttttga tggcatgtgg attgacatga     2940

atgagcccag caacttcatc aggggctctg aggatgggtg ccccaataat gagctggaga     3000

acccccccta tgtgcctggg gtggtggggg gcaccctgca ggctgccact atttgtgcca     3060

gctctcacca gttcctgagc acccactaca acctgcacaa tctgtatggc ctgactgagg     3120

ccattgccag ccacagggcc ctggtgaagg ccaggggcac taggcccttt gtgatctcta     3180

gaagcacctt tgctggccat gggaggtatg ctggccactg gactggggat gtgtggagct     3240

cttgggagca gctggccagc tctgtgcctg agatcctgca gttcaacctg ctgggggtgc     3300

ccctggtggg ggctgatgtg tgtggcttcc tgggcaacac ctctgaagag ctgtgtgtga     3360

ggtggaccca gctgggggcc ttctaccctt tcatgaggaa ccacaacagc ctgctgagcc     3420

tgcctcagga gccttactct ttctctgagc ctgcccagca ggccatgagg aaggccctga     3480

ccctgaggta tgctctgctg ccccacctgt acaccctgtt ccaccaggcc catgtggctg     3540

gggagactgt ggccaggccc ctgttcctgg agtttcctaa ggatagcagc acctggactg     3600

tggaccacca gctgctgtgg ggggaggccc tgctgattac ccctgtgctg caggctggca     3660

aggctgaggt gactggctac ttccccctgg gcacttggta tgacctgcag actgtgcctg     3720

tggaagccct gggcagcctg cctccccccc ctgctgcccc cagggagcct gccatccact     3780

ctgagggcca gtgggtgacc ctgcctgccc ccctggacac cattaatgtg catctgaggg     3840

ctgggtatat tatccccctg caggggcctg ggctgactac cactgagagc aggcagcagc     3900

ctatggccct ggctgtggct ctgactaagg ggggggaggc caggggggag ctgttctggg     3960

atgatgggga gagcctggag gtgctggaga ggggggccta cacccaggtg attttcctgg     4020

ccaggaacaa caccattgtg aatgagctgg tgagggtgac ctctgagggg gctggcctgc     4080

agctgcagaa agtgactgtg ctgggggtgg ccactgcccc ccagcaggtg ctgagcaatg     4140

gggtgcctgt gagcaacttc acctacagcc ctgacaccaa ggtgctggat atttgtgtga     4200

gcctgctgat gggggagcag ttcctggtga gctggtgctg actcgagaga tctaccggtg     4260

aattcaccgc gggtttaaac tgtgccttct agttgccagc catctgttgt ttgcccctcc     4320

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     4380

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtgggggct     4440

agctctagac tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4560

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4611


<210>  21
<211>  4611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  21
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca ggctcagagg cacacaggag tttctgggct      180

caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg tgtgctgcct      240

ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg caaacattgc      300

aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag      360

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg      420

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gtacccgggg      480

atcttgctac cagtggaaca gccactaagg attctgcagt gagagcagag ggccagctaa      540

gtggtactct cccagagact gtctgactca cgccaccccc tccaccttgg acacaggacg      600

ctgtggtttc tgagccaggt acaatgactc ctttcggtaa gtgcagtgga agctgtacac      660

tgcccaggca aagcgtccgg gcagcgtagg cgggcgactc agatcccagc cagtggactt      720

agcccctgtt tgctcctccg ataactgggg tgaccttggt taatattcac cagcagcctc      780

ccccgttgcc cctctggatc cactgcttaa atacggacga ggacagggcc ctgtctcctc      840

agcttcaggc accaccactg acctgggaca gtgaatagat cctgagaact tcagggtgag      900

tctatgggac ccttgatgtt ttctttcccc ttcttttcta tggttaagtt catgtcatag      960

gaaggggaga agtaacaggg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1020

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1080

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1140

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1200

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1260

tccagctacc attctgcttt tattttctgg ttgggataag gctggattat tctgagtcca     1320

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     1380

aacctgctgg tctctctgct ggcccatcac tttggcaaag cacgcgtgcc accatggctt     1440

tcctgtggct gctgtcttgc tgggccctgc tggggactac ctttggcctg ctggtgccca     1500

gggaactgtc tggctctagc ccagtgctgg aggagaccca ccctgcccac cagcaggggg     1560

cttctaggcc tggccccagg gatgcccagg cccaccctgg caggccaagg gctgtgccca     1620

cccagtgtga tgtgcccccc aactctagat ttgattgtgc ccctgataag gccatcaccc     1680

aggagcagtg tgaggctagg ggctgctgct acatccctgc taagcagggc ctgcaggggg     1740

ctcagatggg ccagccctgg tgcttcttcc cccccagcta tccctcttac aagctggaga     1800

atctgagcag ctctgagatg ggctacactg ccaccctgac caggactact cccaccttct     1860

tccccaagga catcctgacc ctgaggctgg atgtgatgat ggagactgag aacaggctgc     1920

atttcaccat caaggatcct gccaacagga ggtatgaggt gcctctggag accccccatg     1980

tgcacagcag ggctccttct cccctgtact ctgtggagtt ctctgaggaa ccctttgggg     2040

tgattgtgag gaggcagctg gatggcaggg tcctgctgaa caccactgtg gcccccctgt     2100

tctttgctga tcagttcctg cagctgtcca cttctctgcc tagccagtac atcactgggc     2160

tggctgagca cctgagccct ctgatgctga gcacctcttg gactaggatc accctgtgga     2220

acagggacct ggcccccacc cctggggcca acctgtatgg cagccacccc ttctatctgg     2280

ccctggagga tgggggctct gcccatgggg tgttcctgct gaatagcaat gctatggatg     2340

tggtgctgca gcccagccct gccctgtctt ggaggagcac tgggggcatc ctggatgtgt     2400

acattttcct ggggcctgag cccaagtctg tggtgcagca gtacctggat gtggtgggct     2460

accccttcat gcctccctac tggggcctgg gcttccacct gtgcaggtgg ggctacagct     2520

ctactgccat caccaggcag gtggtggaga atatgaccag ggcccacttc cccctggatg     2580

tgcagtggaa tgacctggac tacatggact ctaggaggga cttcaccttc aataaggatg     2640

gcttcagaga cttccctgcc atggtgcagg agctgcatca ggggggcagg aggtacatga     2700

tgattgtgga ccctgccatc agctcttctg gccctgctgg ctcttacagg ccctatgatg     2760

agggcctgag gaggggggtg ttcatcacca atgagactgg gcagcccctg attgggaagg     2820

tgtggcctgg ctctactgcc ttccctgact tcaccaatcc tactgccctg gcctggtggg     2880

aggacatggt ggctgagttc catgaccagg tgccctttga tggcatgtgg attgacatga     2940

atgagccctc taatttcatc aggggctctg aggatggctg ccccaacaat gagctggaga     3000

acccccccta tgtgcctggg gtggtggggg gcaccctgca ggctgccacc atctgtgcta     3060

gctctcacca gttcctgagc acccactaca atctgcataa cctgtatggc ctgactgagg     3120

ccattgccag ccacagggcc ctggtgaagg ctaggggcac caggcccttt gtgatttcta     3180

ggagcacttt tgctggccat ggcaggtatg ctgggcactg gactggggat gtgtggtcta     3240

gctgggagca gctggcttct tctgtgcctg agatcctgca gttcaacctg ctgggggtgc     3300

ctctggtggg ggctgatgtg tgtgggttcc tgggcaacac ttctgaggag ctgtgtgtga     3360

ggtggaccca gctgggggcc ttctaccctt tcatgaggaa ccacaacagc ctgctgagcc     3420

tgccccagga gccctacagc ttctctgagc ctgcccagca ggccatgagg aaggccctga     3480

ccctgaggta tgccctgctg ccccacctgt acaccctgtt ccaccaggcc catgtggctg     3540

gggagactgt ggctaggcct ctgttcctgg agttccccaa ggactctagc acctggactg     3600

tggaccacca gctgctgtgg ggggaggccc tgctgatcac tcctgtgctg caggctggga     3660

aggctgaggt gactggctat ttccccctgg gcacctggta tgacctgcag actgtgcctg     3720

tggaggccct ggggagcctg cccccccccc ctgctgcccc cagggagcct gccatccact     3780

ctgagggcca gtgggtgacc ctgcctgccc ctctggatac catcaatgtg cacctgaggg     3840

ctggctacat cattcccctg cagggccctg gcctgaccac tactgagtct aggcagcagc     3900

ccatggccct ggctgtggcc ctgaccaagg ggggggaggc taggggggag ctgttttggg     3960

atgatgggga gagcctggag gtgctggaga ggggggccta cactcaggtg atcttcctgg     4020

ccaggaacaa taccattgtg aatgagctgg tgagggtgac ctctgagggg gctggcctgc     4080

agctgcagaa ggtgactgtg ctgggggtgg ccactgcccc ccagcaggtg ctgagcaatg     4140

gggtgcctgt gagcaacttc acctatagcc ctgataccaa ggtgctggat atttgtgtga     4200

gcctgctgat gggggagcag ttcctggtga gctggtgctg actcgagaga tctaccggtg     4260

aattcaccgc gggtttaaac tgtgccttct agttgccagc catctgttgt ttgcccctcc     4320

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     4380

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtgggggct     4440

agctctagac tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4560

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4611


<210>  22
<211>  4611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  22
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca ggctcagagg cacacaggag tttctgggct      180

caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg tgtgctgcct      240

ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg caaacattgc      300

aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag      360

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg      420

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gtacccgggg      480

atcttgctac cagtggaaca gccactaagg attctgcagt gagagcagag ggccagctaa      540

gtggtactct cccagagact gtctgactca cgccaccccc tccaccttgg acacaggacg      600

ctgtggtttc tgagccaggt acaatgactc ctttcggtaa gtgcagtgga agctgtacac      660

tgcccaggca aagcgtccgg gcagcgtagg cgggcgactc agatcccagc cagtggactt      720

agcccctgtt tgctcctccg ataactgggg tgaccttggt taatattcac cagcagcctc      780

ccccgttgcc cctctggatc cactgcttaa atacggacga ggacagggcc ctgtctcctc      840

agcttcaggc accaccactg acctgggaca gtgaatagat cctgagaact tcagggtgag      900

tctatgggac ccttgatgtt ttctttcccc ttcttttcta tggttaagtt catgtcatag      960

gaaggggaga agtaacaggg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1020

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1080

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1140

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1200

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1260

tccagctacc attctgcttt tattttctgg ttgggataag gctggattat tctgagtcca     1320

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     1380

aacctgctgg tctctctgct ggcccatcac tttggcaaag cacgcgtgcc accatggctt     1440

tcctgtggct gctgtcttgt tgggctctgc tgggcaccac ctttggcctg ctggtgccca     1500

gggagctgtc tggcagcagc cctgtgctgg aggagaccca ccctgctcat cagcaggggg     1560

ctagcaggcc tggccccagg gatgcccagg ctcaccctgg gagacccagg gctgtgccca     1620

ctcagtgtga tgtgcccccc aacagcaggt ttgactgtgc tcctgacaag gctatcaccc     1680

aggagcagtg tgaggccagg gggtgctgct acattcctgc taagcagggc ctgcaggggg     1740

cccagatggg ccagccctgg tgcttcttcc ccccctctta tcccagctat aagctggaga     1800

acctgagcag ctctgagatg ggctacactg ccaccctgac caggaccact cccaccttct     1860

ttcccaagga tattctgact ctgaggctgg atgtgatgat ggagactgag aacaggctgc     1920

acttcactat caaggaccct gccaatagga ggtatgaggt gcccctggag actcctcatg     1980

tgcatagcag ggccccttct cctctgtatt ctgtggagtt ctctgaggag ccctttgggg     2040

tgattgtgag gaggcagctg gatggcaggg tgctgctgaa caccactgtg gcccccctgt     2100

tctttgctga ccagttcctg cagctgagca cttctctgcc cagccagtac attactgggc     2160

tggctgagca tctgagcccc ctgatgctga gcacctcttg gaccaggatc accctgtgga     2220

acagggacct ggcccccact cctggggcta acctgtatgg ctctcacccc ttttacctgg     2280

ccctggagga tgggggctct gcccatgggg tgtttctgct gaacagcaat gctatggatg     2340

tggtgctgca gccctctcca gccctgtctt ggaggagcac tgggggcatt ctggatgtgt     2400

acattttcct ggggcctgaa cccaagtctg tggtgcagca gtacctggat gtggtgggct     2460

accccttcat gcccccctat tgggggctgg ggtttcacct gtgcaggtgg ggctacagca     2520

gcactgccat caccaggcag gtggtggaga acatgaccag ggcccatttc cccctggatg     2580

tgcagtggaa tgacctggac tacatggata gcaggaggga tttcaccttc aacaaggatg     2640

gcttcaggga ctttcctgcc atggtgcagg agctgcacca ggggggcagg aggtatatga     2700

tgattgtgga ccctgctatc agcagctctg gccctgctgg ctcttacagg ccctatgatg     2760

agggcctgag gaggggggtg tttatcacta atgaaactgg ccagcctctg attggcaagg     2820

tctggcctgg ctctactgcc ttccctgatt ttactaaccc cactgccctg gcctggtggg     2880

aggacatggt ggctgagttc catgatcagg tgccttttga tggcatgtgg attgatatga     2940

atgaaccaag caacttcatc agaggctctg aggatggctg ccccaacaat gagctggaga     3000

acccccccta tgtgcctggg gtggtggggg gcactctgca ggctgccacc atttgtgcta     3060

gcagccacca gttcctgagc acccactaca atctgcacaa cctgtatggc ctgactgaag     3120

ccattgccag ccatagggcc ctggtgaagg ccaggggcac taggcctttt gtgatcagca     3180

ggagcacttt tgctggccat ggcaggtatg ctggccactg gactggggat gtgtggagca     3240

gctgggagca gctggccagc tctgtgcctg agattctgca gtttaacctg ctgggggtgc     3300

ccctggtggg ggctgatgtg tgtggcttcc tgggcaacac ctctgaggag ctgtgtgtga     3360

ggtggaccca gctgggggcc ttttatccct tcatgaggaa ccacaacagc ctgctgagcc     3420

tgcctcagga gccctactct ttctctgagc ctgcccagca ggccatgagg aaggccctga     3480

ccctgaggta tgccctgctg ccccacctgt ataccctgtt ccaccaggcc catgtggctg     3540

gggagactgt ggccaggccc ctgttcctgg agttccccaa ggacagcagc acctggactg     3600

tggatcatca gctgctgtgg ggggaggccc tgctgatcac ccctgtgctg caggctggca     3660

aggctgaggt cactggctac ttccctctgg gcacctggta tgacctgcag actgtgcctg     3720

tggaggctct gggcagcctg cccccccccc ctgctgctcc cagggagcct gccatccact     3780

ctgagggcca gtgggtgacc ctgcctgctc ccctggacac catcaatgtg cacctgaggg     3840

ctggctacat tatccccctg cagggcccag ggctgactac cactgagagc agacagcagc     3900

ccatggctct ggctgtggcc ctgaccaagg ggggggaagc taggggggag ctgttctggg     3960

atgatgggga gagcctggag gtgctggaga ggggggccta tacccaggtg atcttcctgg     4020

ctaggaacaa caccattgtc aatgagctgg tgagggtgac ttctgagggg gctgggctgc     4080

agctgcagaa ggtgactgtg ctgggggtgg ccactgctcc ccagcaggtg ctgagcaatg     4140

gggtgcctgt gagcaacttc acctacagcc ctgacaccaa ggtgctggac atctgtgtgt     4200

ctctgctgat gggggagcag ttcctggtga gctggtgctg actcgagaga tctaccggtg     4260

aattcaccgc gggtttaaac tgtgccttct agttgccagc catctgttgt ttgcccctcc     4320

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     4380

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtgggggct     4440

agctctagac tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4560

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4611


<210>  23
<211>  4611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  23
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca ggctcagagg cacacaggag tttctgggct      180

caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg tgtgctgcct      240

ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg caaacattgc      300

aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag      360

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg      420

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gtacccgggg      480

atcttgctac cagtggaaca gccactaagg attctgcagt gagagcagag ggccagctaa      540

gtggtactct cccagagact gtctgactca cgccaccccc tccaccttgg acacaggacg      600

ctgtggtttc tgagccaggt acaatgactc ctttcggtaa gtgcagtgga agctgtacac      660

tgcccaggca aagcgtccgg gcagcgtagg cgggcgactc agatcccagc cagtggactt      720

agcccctgtt tgctcctccg ataactgggg tgaccttggt taatattcac cagcagcctc      780

ccccgttgcc cctctggatc cactgcttaa atacggacga ggacagggcc ctgtctcctc      840

agcttcaggc accaccactg acctgggaca gtgaatagat cctgagaact tcagggtgag      900

tctatgggac ccttgatgtt ttctttcccc ttcttttcta tggttaagtt catgtcatag      960

gaaggggaga agtaacaggg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1020

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1080

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1140

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1200

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1260

tccagctacc attctgcttt tattttctgg ttgggataag gctggattat tctgagtcca     1320

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     1380

aacctgctgg tctctctgct ggcccatcac tttggcaaag cacgcgtgcc accatggcct     1440

tcctgtggct gctgtcttgc tgggctctgc tggggaccac ctttggcctg ctggtcccca     1500

gggagctgtc tggctcttct cctgtcctgg aggagaccca ccctgcccac cagcaggggg     1560

ctagcaggcc tggccccagg gatgcccagg cccaccctgg caggcccagg gctgtgccca     1620

cccagtgtga tgtgcctccc aacagcaggt ttgactgtgc ccctgacaag gccatcaccc     1680

aggagcagtg tgaggccagg ggctgctgct atatccctgc caagcagggc ctgcaggggg     1740

ctcagatggg ccagccctgg tgcttctttc ccccctctta tcctagctat aagctggaga     1800

acctgagcag ctctgagatg gggtacactg ccaccctgac caggaccacc cccactttct     1860

tccctaagga catcctgacc ctgaggctgg atgtgatgat ggagactgag aataggctgc     1920

actttactat caaggaccct gccaacagga ggtatgaggt gcctctggag accccccatg     1980

tgcattctag ggcccccagc cccctgtact ctgtggagtt ctctgaggag ccctttgggg     2040

tgattgtgag gagacagctg gatggcaggg tcctgctgaa caccactgtg gctcccctgt     2100

tttttgctga ccagttcctg cagctgagca ccagcctgcc cagccagtac atcactgggc     2160

tggctgagca cctgagcccc ctgatgctga gcaccagctg gaccaggatc accctgtgga     2220

acagggatct ggctcctacc cctggggcca acctgtatgg ctctcacccc ttttacctgg     2280

ccctggagga tgggggctct gcccatgggg tgttcctgct gaacagcaat gctatggatg     2340

tggtgctgca gcccagccct gccctgagct ggaggtctac tgggggcatc ctggatgtgt     2400

acatctttct ggggcctgag cccaagtctg tggtgcagca gtacctggat gtggtgggct     2460

atccttttat gcccccctat tggggcctgg gcttccacct gtgcaggtgg ggctacagca     2520

gcactgccat caccagacag gtggtggaga acatgaccag ggcccacttc cccctggatg     2580

tgcagtggaa tgacctggac tacatggaca gcaggaggga cttcaccttt aacaaggatg     2640

gctttaggga cttccctgcc atggtgcagg agctgcatca ggggggcagg aggtacatga     2700

tgattgtgga cccagccatc agcagctctg ggcctgctgg gtcttacagg ccctatgatg     2760

agggcctgag gaggggggtg ttcatcacca atgagactgg ccagcccctg attggcaagg     2820

tgtggcctgg gagcactgcc ttccctgatt ttaccaaccc cactgccctg gcctggtggg     2880

aggatatggt ggctgagttt catgaccagg tgccctttga tggcatgtgg attgacatga     2940

atgagcccag caatttcatc aggggctctg aggatggctg ccccaacaat gagctggaga     3000

atcctcccta tgtgcctggg gtggtggggg gcaccctgca ggctgccacc atctgtgcct     3060

ctagccacca gttcctgagc acccactata acctgcataa cctgtatggc ctgactgagg     3120

ccattgccag ccatagagcc ctggtgaagg ccagagggac caggcccttt gtgatctcta     3180

ggagcacctt tgctggccat ggcaggtatg ctggccactg gactggggat gtgtggagct     3240

cttgggagca gctggccagc tctgtgccag agatcctgca gttcaacctg ctgggggtgc     3300

ctctggtggg ggctgatgtg tgtggcttcc tgggcaatac ctctgaagag ctgtgtgtga     3360

ggtggactca gctgggggcc ttctatccct tcatgaggaa ccacaacagc ctgctgtctc     3420

tgccccagga gccctacagc ttctctgagc ctgctcagca ggctatgagg aaggccctga     3480

ccctgaggta tgccctgctg ccccatctgt acaccctgtt ccaccaggcc catgtggctg     3540

gggagactgt ggccaggccc ctgtttctgg agtttcccaa ggacagcagc acctggactg     3600

tggaccatca gctgctgtgg ggggaggctc tgctgattac ccctgtgctg caggctggca     3660

aggctgaggt gactgggtac ttccccctgg ggacttggta tgacctgcag actgtgcctg     3720

tggaagctct gggcagcctg cccccacccc ctgctgcccc tagggagcct gccatccact     3780

ctgagggcca gtgggtgacc ctgcctgccc ctctggacac catcaatgtg cacctgaggg     3840

ctggctatat catccccctg cagggccctg ggctgaccac cactgagagc aggcagcagc     3900

ccatggccct ggctgtggcc ctgactaagg ggggggaggc caggggggag ctgttctggg     3960

atgatgggga gagcctggag gtgctggaga gaggggccta cacccaggtg atctttctgg     4020

ccaggaacaa caccattgtg aatgagctgg tgagggtgac ttctgagggg gctggcctgc     4080

agctgcagaa ggtgactgtg ctgggggtgg ccactgcccc ccagcaggtg ctgagcaatg     4140

gggtgcctgt gtctaacttc acctacagcc ctgatactaa ggtgctggat atctgtgtga     4200

gcctgctgat gggggagcag tttctggtga gctggtgctg actcgagaga tctaccggtg     4260

aattcaccgc gggtttaaac tgtgccttct agttgccagc catctgttgt ttgcccctcc     4320

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     4380

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtgggggct     4440

agctctagac tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4560

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4611


<210>  24
<211>  4611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  24
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca ggctcagagg cacacaggag tttctgggct      180

caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg tgtgctgcct      240

ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg caaacattgc      300

aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag      360

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg      420

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gtacccgggg      480

atcttgctac cagtggaaca gccactaagg attctgcagt gagagcagag ggccagctaa      540

gtggtactct cccagagact gtctgactca cgccaccccc tccaccttgg acacaggacg      600

ctgtggtttc tgagccaggt acaatgactc ctttcggtaa gtgcagtgga agctgtacac      660

tgcccaggca aagcgtccgg gcagcgtagg cgggcgactc agatcccagc cagtggactt      720

agcccctgtt tgctcctccg ataactgggg tgaccttggt taatattcac cagcagcctc      780

ccccgttgcc cctctggatc cactgcttaa atacggacga ggacagggcc ctgtctcctc      840

agcttcaggc accaccactg acctgggaca gtgaatagat cctgagaact tcagggtgag      900

tctatgggac ccttgatgtt ttctttcccc ttcttttcta tggttaagtt catgtcatag      960

gaaggggaga agtaacaggg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1020

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1080

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1140

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1200

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1260

tccagctacc attctgcttt tattttctgg ttgggataag gctggattat tctgagtcca     1320

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     1380

aacctgctgg tctctctgct ggcccatcac tttggcaaag cacgcgtgcc accatggcct     1440

ttctgtggct gctgtcctgc tgggccctgc tggggaccac ctttggcctg ctggtgccca     1500

gggagctgtc tgggagcagc ccagtgctgg aggagaccca ccctgcccac cagcaggggg     1560

ccagcaggcc tggccctagg gatgcccagg cccaccctgg caggcccagg gctgtgccta     1620

cccagtgtga tgtgccaccc aattctaggt ttgactgtgc tcctgacaag gccatcactc     1680

aggagcagtg tgaagctagg gggtgctgct acatcccagc caagcagggc ctgcaggggg     1740

cccagatggg ccagccctgg tgcttcttcc cccccagcta ccctagctac aagctggaga     1800

atctgagcag ctctgagatg ggctacactg ctaccctgac caggaccact cctaccttct     1860

tccccaagga catcctgact ctgaggctgg atgtcatgat ggagactgaa aataggctgc     1920

acttcaccat caaggaccct gccaatagga ggtatgaggt gcctctggag accccccatg     1980

tgcatagcag ggctcccagc cccctgtatt ctgtggagtt ctctgaggag ccctttgggg     2040

tcattgtgag gagacagctg gatgggaggg tgctgctgaa cactactgtg gctcccctgt     2100

tctttgctga ccagttcctg cagctgtcta ccagcctgcc cagccagtac atcactgggc     2160

tggctgagca tctgagcccc ctgatgctga gcaccagctg gaccaggatc actctgtgga     2220

acagggatct ggcccccact cctggggcca acctgtatgg gagccatccc ttctacctgg     2280

ccctggagga tgggggctct gcccatgggg tgttcctgct gaacagcaat gccatggatg     2340

tggtgctgca gcctagccct gccctgagct ggaggagcac tgggggcatc ctggatgtct     2400

acatcttcct ggggcctgag cccaagtctg tggtgcagca gtatctggat gtggtggggt     2460

atcccttcat gcccccctac tggggcctgg gctttcacct gtgcaggtgg ggctacagca     2520

gcactgccat caccaggcag gtggtggaga acatgaccag ggcccacttc cctctggatg     2580

tgcagtggaa tgacctggac tatatggatt ctaggagaga ctttactttt aacaaggatg     2640

gcttcaggga tttccctgcc atggtgcagg agctgcacca ggggggcagg aggtacatga     2700

tgattgtgga ccctgctatt agcagctctg gccctgctgg gtcttacagg ccttatgatg     2760

agggcctgag gaggggggtg ttcatcacca atgagactgg ccagcccctg attggcaagg     2820

tgtggcctgg cagcactgcc ttccctgact tcaccaaccc cactgccctg gcctggtggg     2880

aggacatggt ggctgagttc catgaccagg tgccctttga tgggatgtgg attgacatga     2940

atgagccctc taacttcatc agggggtctg aggatggctg ccccaacaat gagctggaga     3000

acccccccta tgtgcctggg gtggtggggg gcactctgca ggctgccact atctgtgctt     3060

cttctcacca gtttctgagc acccactata atctgcacaa cctgtatggc ctgactgagg     3120

ccattgccag ccatagggcc ctggtgaagg ccaggggcac caggcccttt gtgatcagca     3180

ggtctacctt tgctggccat ggcaggtatg ctggccactg gactggggat gtgtggtctt     3240

cttgggagca gctggccagc tctgtgcctg agatcctgca gttcaacctg ctgggggtgc     3300

ctctggtggg ggctgatgtg tgtggctttc tgggcaacac ctctgaggag ctgtgtgtga     3360

ggtggaccca gctgggggcc ttttacccct tcatgaggaa ccacaatagc ctgctgagcc     3420

tgccccagga gccttactct ttctctgagc ctgcccagca ggccatgagg aaggccctga     3480

ctctgaggta tgccctgctg ccccatctgt ataccctgtt tcaccaggcc catgtggctg     3540

gggagactgt ggctaggcct ctgtttctgg agttccctaa ggactctagc acctggactg     3600

tggaccacca gctgctgtgg ggggaggccc tgctgatcac ccctgtgctg caggctggca     3660

aggctgaggt gactggctac ttccccctgg gcacctggta tgacctgcag actgtgcctg     3720

tggaggccct ggggagcctg cctccccccc ctgctgcccc cagggagcct gccattcatt     3780

ctgagggcca gtgggtgacc ctgcctgccc ctctggacac catcaatgtg cacctgaggg     3840

ctgggtacat catccccctg cagggccctg gcctgaccac cactgagagc aggcagcagc     3900

ccatggccct ggctgtggct ctgaccaagg ggggggaggc caggggggag ctgttctggg     3960

atgatgggga gtctctggag gtgctggaga ggggggccta cacccaggtg atctttctgg     4020

ccaggaacaa tactattgtg aatgagctgg tgagggtgac ctctgagggg gctggcctgc     4080

agctgcagaa ggtgactgtg ctgggggtgg ccactgcccc ccagcaggtc ctgagcaatg     4140

gggtgcctgt gagcaacttc acctactctc ctgacaccaa ggtgctggac atttgtgtgt     4200

ctctgctgat gggggagcag ttcctggtga gctggtgctg actcgagaga tctaccggtg     4260

aattcaccgc gggtttaaac tgtgccttct agttgccagc catctgttgt ttgcccctcc     4320

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     4380

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtgggggct     4440

agctctagac tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     4500

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4560

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g              4611


<210>  25
<211>  935
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAA peptide

<400>  25

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val Leu 
            20                  25                  30          


Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly Pro 
        35                  40                  45              


Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln 
    50                  55                  60                  


Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala 
65                  70                  75                  80  


Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala 
                85                  90                  95      


Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe 
            100                 105                 110         


Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu 
        115                 120                 125             


Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro 
    130                 135                 140                 


Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn 
145                 150                 155                 160 


Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val 
                165                 170                 175     


Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr 
            180                 185                 190         


Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln 
        195                 200                 205             


Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe 
    210                 215                 220                 


Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile 
225                 230                 235                 240 


Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp 
                245                 250                 255     


Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala 
            260                 265                 270         


Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly 
        275                 280                 285             


Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val 
    290                 295                 300                 


Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln 
                325                 330                 335     


Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu 
            340                 345                 350         


Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg 
        355                 360                 365             


Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln 
    370                 375                 380                 


Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn 
385                 390                 395                 400 


Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln 
                405                 410                 415     


Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser 
            420                 425                 430         


Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly 
        435                 440                 445             


Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp 
    450                 455                 460                 


Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala 
465                 470                 475                 480 


Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp 
                485                 490                 495     


Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser 
            500                 505                 510         


Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro 
        515                 520                 525             


Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser 
    530                 535                 540                 


His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu 
545                 550                 555                 560 


Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr 
                565                 570                 575     


Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr 
            580                 585                 590         


Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala 
        595                 600                 605             


Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu 
    610                 615                 620                 


Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu 
625                 630                 635                 640 


Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn 
                645                 650                 655     


His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu 
            660                 665                 670         


Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu 
        675                 680                 685             


Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu 
    690                 695                 700                 


Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr 
705                 710                 715                 720 


Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr 
                725                 730                 735     


Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu 
            740                 745                 750         


Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser 
        755                 760                 765             


Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu 
    770                 775                 780                 


Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His 
785                 790                 795                 800 


Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr 
                805                 810                 815     


Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys 
            820                 825                 830         


Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu 
        835                 840                 845             


Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg 
    850                 855                 860                 


Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala 
865                 870                 875                 880 


Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro 
                885                 890                 895     


Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser 
            900                 905                 910         


Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu 
        915                 920                 925             


Gln Phe Leu Val Ser Trp Cys 
    930                 935 


<210>  26
<211>  268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Nucleic Acid

<400>  26
agatctagag ctgaattcct gcagccaggg ggatcagcct ctactgtgcc ttctagttgc       60

cagccatctg ttgtttgccc ctcccccttg ccttccttga ccctggaagg tgccactccc      120

actgtccttt cctaataaaa tgaggaaatt gcatcacatt gtctgagtag gtgtcattct      180

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg      240

catgctgggg atgcagtggg ctctatgg                                         268


<210>  27
<211>  202
<212>  DNA
<213>  Bos taurus

<400>  27
agatctaccg gtgaattcac cgcgggttta aactgtgcct tctagttgcc agccatctgt       60

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc      120

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg      180

tggggtgggg gctagctcta ga                                               202


<210>  28
<211>  456
<212>  DNA
<213>  Homo sapiens

<400>  28
gggcccatgc cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga       60

ggttgtcctg gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg      120

gaacagccac taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag      180

agactgtctg actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc      240

caggtacaat gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg      300

tccgggcagc gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc      360

ctccgataac tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct      420

ggatccactg cttaaatacg gacgaggaca gggccc                                456


<210>  29
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  29
atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt       60

cctggcgtgg tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag      120

ccactaagga ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg      180

tctgactcac gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta      240

caatgactcc tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg      300

cagcgtaggc gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga      360

taactggggt gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc      420

actgcttaaa tacggacgag gaca                                             444


<210>  30
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV vector capsid

<400>  30

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  31
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV vector capsid

<400>  31

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Pro Ser Pro Gln Arg Ser 
1               5                   10                  15      


Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Lys 
            20                  25                  30          


Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp 
        35                  40                  45              


Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser Gly Leu Gly Ser 
    50                  55                  60                  


Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu 
65                  70                  75                  80  


Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser 
                85                  90                  95      


Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala 
            100                 105                 110         


Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr 
        115                 120                 125             


Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro 
    130                 135                 140                 


Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg 
145                 150                 155                 160 


Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg 
                165                 170                 175     


Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn 
            180                 185                 190         


Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val 
        195                 200                 205             


Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His 
    210                 215                 220                 


Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln 
225                 230                 235                 240 


Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser 
                245                 250                 255     


Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
            260                 265                 270         


Asn Asn Phe Glu Phe Ser Tyr Asn Phe Glu Asp Val Pro Phe His Ser 
        275                 280                 285             


Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
    290                 295                 300                 


Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly Gly Thr 
305                 310                 315                 320 


Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn Asn Met 
                325                 330                 335     


Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
            340                 345                 350         


Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe Ala Trp 
        355                 360                 365             


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn 
    370                 375                 380                 


Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe 
385                 390                 395                 400 


Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly Lys Asp 
                405                 410                 415     


Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu Ile Lys 
            420                 425                 430         


Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala Asp Asn 
        435                 440                 445             


Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn Ser Gln 
    450                 455                 460                 


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
465                 470                 475                 480 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
                485                 490                 495     


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
            500                 505                 510         


Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn 
        515                 520                 525             


Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
    530                 535                 540                 


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
545                 550                 555                 560 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Asn Val 
                565                 570                 575     


Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg Pro Ile 
            580                 585                 590         


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        595                 600     


<210>  32
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV vector capsid

<400>  32

Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly 
    50                  55                  60                  


Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly 
        115                 120                 125             


Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Glu Phe Ser Tyr Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly 
                245                 250                 255     


Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala 
            260                 265                 270         


Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 
        275                 280                 285             


Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly 
    290                 295                 300                 


Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly 
305                 310                 315                 320 


Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser 
                325                 330                 335     


Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val 
            340                 345                 350         


Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr 
        355                 360                 365             


Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln 
    370                 375                 380                 


Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro 
                405                 410                 415     


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
            420                 425                 430         


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala 
    450                 455                 460                 


Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
465                 470                 475                 480 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe 
            500                 505                 510         


Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Arg Asn Leu 
    530                 535 


<210>  33
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV vector capsid

<400>  33

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


