                               SEQUENCE LISTING

<110> HARPOON THERAPEUTICS, INC.
 
<120> CONDITIONALLY ACTIVATED BINDING PROTEIN COMPRISING A STERICALLY 
      OCCLUDED TARGET BINDING DOMAIN

<130> 47517-732.601

<140> PCT/US2019/032306
<141> 2019-05-14

<150> 62/756,498
<151> 2018-11-06

<150> 62/671,355
<151> 2018-05-14

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 1
Lys Arg Ala Leu Gly Leu Pro Gly 
1               5               


<210> 2
<211> 40
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 2
Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu 
1               5                   10                  15      


Arg Pro Leu Ala Leu Trp Arg Ser Asp Arg Asp Arg Asp Arg Asp Arg 
            20                  25                  30          


Asp Arg Asp Arg Asp Arg Asp Arg 
        35                  40  


<210> 3
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ser or Thr

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser or Thr

<400> 3
Pro Arg Xaa Xaa Xaa 
1               5   


<210> 4
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 4
Leu Glu Ala Thr Ala 
1               5   


<210> 5
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 5
Gly Gly Ala Ala Asn Leu Val Arg Gly Gly 
1               5                   10  


<210> 6
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 6
Ser Gly Arg Ile Gly Phe Leu Arg Thr Ala 
1               5                   10  


<210> 7
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 7
Pro Leu Gly Leu Ala Gly 
1               5       


<210> 8
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 8
Pro Leu Gly Leu Ala Xaa 
1               5       


<210> 9
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 9
Pro Leu Gly Cys Ala Gly 
1               5       


<210> 10
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 10
Glu Ser Pro Ala Tyr Tyr Thr Ala 
1               5               


<210> 11
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 11
Arg Leu Gln Leu Lys Leu 
1               5       


<210> 12
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 12
Arg Leu Gln Leu Lys Ala Cys 
1               5           


<210> 13
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Cit

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Hof

<400> 13
Glu Pro Xaa Gly Xaa Tyr Leu 
1               5           


<210> 14
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 14
Ser Gly Arg Ser Ala 
1               5   


<210> 15
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 15
Asp Ala Phe Lys 
1               


<210> 16
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 16
Gly Gly Gly Arg Arg 
1               5   


<210> 17
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 17
Gly Phe Leu Gly 
1               


<210> 18
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 18
Ala Leu Ala Leu 
1               


<210> 19
<211> 2
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 19
Phe Lys 
1       


<210> 20
<211> 3
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 20
Asn Leu Leu 
1           


<210> 21
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 21
Pro Ile Cys Phe Phe 
1               5   


<210> 22
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 22
Gly Gly Pro Arg Gly Leu Pro Gly 
1               5               


<210> 23
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 23
His Ser Ser Lys Leu Gln 
1               5       


<210> 24
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 24
His Ser Ser Lys Leu Gln Leu 
1               5           


<210> 25
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 25
His Ser Ser Lys Leu Gln Glu Asp Ala 
1               5                   


<210> 26
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 26
Leu Val Leu Ala Ser Ser Ser Phe Gly Tyr 
1               5                   10  


<210> 27
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 27
Gly Val Ser Gln Asn Tyr Pro Ile Val Gly 
1               5                   10  


<210> 28
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 28
Gly Val Val Gln Ala Ser Cys Arg Leu Ala 
1               5                   10  


<210> 29
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Pip

<400> 29
Phe Xaa Arg Ser 
1               


<210> 30
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 30
Asp Pro Arg Ser Phe Leu 
1               5       


<210> 31
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 31
Pro Pro Arg Ser Phe Leu 
1               5       


<210> 32
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 32
Asp Glu Val Asp 
1               


<210> 33
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 33
Asp Glu Val Asp Pro 
1               5   


<210> 34
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 34
Lys Gly Ser Gly Asp Val Glu Gly 
1               5               


<210> 35
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 35
Gly Trp Glu His Asp Gly 
1               5       


<210> 36
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 36
Glu Asp Asp Asp Asp Lys Ala 
1               5           


<210> 37
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 37
Lys Gln Glu Gln Asn Pro Gly Ser Thr 
1               5                   


<210> 38
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 38
Gly Lys Ala Phe Arg Arg 
1               5       


<210> 39
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 39
Asp Ala Phe Lys 
1               


<210> 40
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 40
Asp Val Leu Lys 
1               


<210> 41
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 41
Asp Ala Phe Lys 
1               


<210> 42
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 42
Ala Leu Leu Leu Ala Leu Leu 
1               5           


<210> 43
<211> 115
<212> PRT
<213> Homo sapiens

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 44
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 45
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ala Asp Thr Leu Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Lys Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 46
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Lys Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 47
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Thr Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 48
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Lys Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 49
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 50
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 51
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Thr Asp Thr Leu Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 52
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 53
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 54
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gly Gly Gly Gly Lys Pro Leu Gly Leu Gln Ala Arg Val Val Gly Gly 
1               5                   10                  15      


Gly Gly Thr 
            


<210> 55
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210> 57
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ala Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser His 
        115                 120                 125             


His His His His His 
    130             


<210> 58
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                165                 170                 175     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    210                 215                 220                 


His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210> 59
<211> 372
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ile Phe Arg Ala Ala Ser Met Ala Trp Tyr Arg Gln Ser Pro Gly Asn 
    50                  55                  60                  


Glu Arg Glu Leu Val Ala Ser Ile Ser Ser Gly Ala Phe Thr Asn Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gly Ala Thr Phe Leu Arg Ser Asp Gly His His Thr 
        115                 120                 125             


Ile Asn Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Asp Tyr 
    130                 135                 140                 


Lys Asp Asp Asp Asp Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
145                 150                 155                 160 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
                165                 170                 175     


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
            180                 185                 190         


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
        195                 200                 205             


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210> 60
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Gly Ser Gly Glu Val Gln Leu Leu Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Ile Phe Arg Ala Ala Ser Met Ala Trp Tyr Arg Gln 
            180                 185                 190         


Ser Pro Gly Asn Glu Arg Glu Leu Val Ala Ser Ile Ser Ser Gly Ala 
        195                 200                 205             


Phe Thr Asn Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Gly Ala Thr Phe Leu Arg Ser Asp 
                245                 250                 255     


Gly His His Thr Ile Asn Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Thr Ser Asp Tyr Lys Asp Asp Asp Asp Lys Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210> 61
<211> 368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
65                  70                  75                  80  


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                85                  90                  95      


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Asp Tyr Lys Asp Asp Asp 
    130                 135                 140                 


Asp Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210> 62
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 62
Lys Pro Leu Gly Leu Gln Ala Arg Val Val 
1               5                   10  


<210> 63
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 63
Pro Gln Ala Ser Thr Gly Arg Ser Gly Gly 
1               5                   10  


<210> 64
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 64
Pro Gln Gly Ser Thr Gly Arg Ala Ala Gly 
1               5                   10  


<210> 65
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 65
Pro Pro Ala Ser Ser Gly Arg Ala Gly Gly 
1               5                   10  


<210> 66
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 66
Pro Ile Pro Val Gln Gly Arg Ala His 
1               5                   


<210> 67
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage site sequence

<400> 67
Pro Gln Gly Ser Thr Ala Arg Ser Ala Gly 
1               5                   10  


<210> 68
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      metalloproteinase cleavage site

<400> 68
Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210> 69
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      metalloproteinase cleavage site

<400> 69
Ala Val Arg Trp Leu Leu Thr Ala 
1               5               


<210> 70
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      furin cleavage site

<400> 70
Arg Arg Arg Arg Arg Arg 
1               5       


