                         SEQUENCE LISTING - Correction

<110>  Immunomic Therapeutics, Inc
 
<120>  IMPROVED LAMP CONSTRUCTS COMPRISING ALLERGENS

<130>  ITI-13-PCT

<150>  US 62/672,005
<151>  2018-05-15

<150>  US 62/672,378
<151>  2018-05-16

<150>  US 62/673,932
<151>  2018-05-20

<160>  250   

<170>  PatentIn version 3.5

<210>  1
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe 
        275                 280                 285             


Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  2
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  3
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  4
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 
            180                 185                 190         


Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala 
            340                 345                 350         


Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  5
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val 
                165                 170                 175     


Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg 
            180                 185                 190         


Asn Tyr His Thr Leu 
        195         


<210>  6
<211>  406
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Ala Pro Gly Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Leu Ala His Gly Ala Ser Ala Leu Phe Glu Val Lys Asn Asn Gly 
            20                  25                  30          


Thr Thr Cys Ile Met Ala Ser Phe Ser Ala Ser Phe Leu Thr Thr Tyr 
        35                  40                  45              


Glu Thr Ala Asn Gly Ser Gln Ile Val Asn Ile Ser Leu Pro Ala Ser 
    50                  55                  60                  


Ala Glu Val Leu Lys Asn Gly Ser Ser Cys Gly Lys Glu Asn Val Ser 
65                  70                  75                  80  


Asp Pro Ser Leu Thr Ile Thr Phe Gly Arg Gly Tyr Leu Leu Thr Leu 
                85                  90                  95      


Asn Phe Thr Lys Asn Thr Thr Arg Tyr Ser Val Gln His Met Tyr Phe 
            100                 105                 110         


Thr Tyr Asn Leu Ser Asp Thr Glu His Phe Pro Asn Ala Ile Ser Lys 
        115                 120                 125             


Glu Ile Tyr Thr Met Asp Ser Thr Thr Asp Ile Lys Ala Asp Ile Asn 
    130                 135                 140                 


Lys Ala Tyr Arg Cys Val Ser Asp Ile Arg Val Tyr Met Lys Asn Val 
145                 150                 155                 160 


Thr Val Val Leu Arg Asp Ala Thr Ile Gln Ala Tyr Leu Ser Ser Gly 
                165                 170                 175     


Asn Phe Ser Lys Glu Glu Thr His Cys Thr Gln Asp Gly Pro Ser Pro 
            180                 185                 190         


Thr Thr Gly Pro Pro Ser Pro Ser Pro Pro Leu Val Pro Thr Asn Pro 
        195                 200                 205             


Thr Val Ser Lys Tyr Asn Val Thr Gly Asn Asn Gly Thr Cys Leu Leu 
    210                 215                 220                 


Ala Ser Met Ala Leu Gln Leu Asn Ile Thr Tyr Leu Lys Lys Asp Asn 
225                 230                 235                 240 


Lys Thr Val Thr Arg Ala Phe Asn Ile Ser Pro Asn Asp Thr Ser Ser 
                245                 250                 255     


Gly Ser Cys Gly Ile Asn Leu Val Thr Leu Lys Val Glu Asn Lys Asn 
            260                 265                 270         


Arg Ala Leu Glu Leu Gln Phe Gly Met Asn Ala Ser Ser Ser Leu Phe 
        275                 280                 285             


Phe Leu Gln Gly Val Arg Leu Asn Met Thr Leu Pro Asp Ala Leu Val 
    290                 295                 300                 


Pro Thr Phe Ser Ile Ser Asn His Ser Leu Lys Ala Leu Gln Ala Thr 
305                 310                 315                 320 


Val Gly Asn Ser Tyr Lys Cys Asn Thr Glu Glu His Ile Phe Val Ser 
                325                 330                 335     


Lys Met Leu Ser Leu Asn Val Phe Ser Val Gln Val Gln Ala Phe Lys 
            340                 345                 350         


Val Asp Ser Asp Arg Phe Gly Ser Val Glu Glu Cys Val Gln Asp Gly 
        355                 360                 365             


Asn Asn Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu 
    370                 375                 380                 


Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His 
385                 390                 395                 400 


Ala Gly Tyr Gln Thr Ile 
                405     


<210>  7
<211>  411
<212>  PRT
<213>  Danio rerio

<400>  7

Met Ala Arg Ala Ala Gly Val Cys Trp Thr Leu Leu Met Gly Cys Val 
1               5                   10                  15      


Phe Ala Ala His Ala Val Thr Phe Glu Val Thr Asp Gly Asn Ser Thr 
            20                  25                  30          


Cys Ile Lys Gly Glu Leu Asn Ala Ser Phe Ser Ile Ser Tyr Asn Thr 
        35                  40                  45              


Thr Asn Gly Thr Ser Val Ser Val Phe Ala Leu Pro Ala Ser Ala Ser 
    50                  55                  60                  


Val Ser Glu Arg Ser Ser Cys Gly Ser Ala Ala Val Pro Pro Glu Leu 
65                  70                  75                  80  


Ala Leu Val Phe Gly Asp Thr His Thr His Thr Leu Ser Leu Leu Phe 
                85                  90                  95      


Ser Arg Asp Gln Arg Leu Tyr Arg Val Ser Asn Ile Ser Leu Gln Tyr 
            100                 105                 110         


Asn Leu Ser Asp Gly Asp Ile Phe Pro Gln Ser Ser Ser Ala Gly Val 
        115                 120                 125             


Gln Ser Val Met Ala Ser Val Ser Glu Leu Met Ser Ala Arg Leu Asn 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Ser Ser Ser Ile Ser Leu Ser Ala Ala 
145                 150                 155                 160 


Val Asn Leu Thr Leu Ser Gly Val Gln Met Glu Ala Tyr Met Ser Ser 
                165                 170                 175     


Ala Asn Leu Ser Ala Asp Glu Ser Val Cys Ser Ala Asp Gln Pro Ser 
            180                 185                 190         


Thr Thr Val Ala Pro Pro Pro Ser Thr Thr Thr Ser Pro Pro Pro Ile 
        195                 200                 205             


Pro Pro Val Pro Glu Arg Gly Asn Tyr Ser Val Thr Asp Gly Asn Gly 
    210                 215                 220                 


Thr Val Cys Val Leu Ala Leu Met Gly Leu Gln Leu Asn Ile Thr His 
225                 230                 235                 240 


Thr Thr Thr Gln Asn Gln Ser Val Ser Glu Leu Met Asn Leu Gln Pro 
                245                 250                 255     


Asn Gln Thr Thr Val Ser Gly Ser Cys Gly Val Thr Glu Ser Ser Leu 
            260                 265                 270         


Arg Leu Ser Asp Glu Thr Thr Asn Leu Thr Phe Ser Phe Thr Met Asn 
        275                 280                 285             


Ser Thr Thr Gln Lys Tyr Tyr Leu Ser Ala Val Ser Val Ser Ala Leu 
    290                 295                 300                 


Trp Pro Asp Met Ser Val Val Phe Glu Ala Gly Asn Thr Ser Leu Ser 
305                 310                 315                 320 


Ala Leu Gln Cys Ser Val Gly Arg Ser Tyr Val Cys Ser Ala Gln Gln 
                325                 330                 335     


Met Leu Ser Val Thr Pro Val Phe Ser Ile Asn Thr Phe Arg Leu Gln 
            340                 345                 350         


Leu Gln Pro Phe Asn Ile Thr Ala Asn Arg Phe Ser Thr Ala Glu Glu 
        355                 360                 365             


Cys Arg Val Asp Gln Glu Asn Met Leu Ile Pro Ile Ile Val Gly Ala 
    370                 375                 380                 


Ala Leu Ala Gly Leu Val Leu Ile Val Leu Val Ala Tyr Leu Ile Gly 
385                 390                 395                 400 


Arg Lys Arg Thr His Ala Gly Tyr Gln Thr Ile 
                405                 410     


<210>  8
<211>  417
<212>  PRT
<213>  Xenopus laevis

<400>  8

Met Ser Trp Arg Gln Val Lys Met Pro Val Tyr Trp Met Ala Val Met 
1               5                   10                  15      


Leu Leu Ile Gly Val Val Gln Val Ala Thr Ala Val Gln Phe Glu Val 
            20                  25                  30          


Lys Asp Gly Lys Thr Asn Ile Thr Cys Ile Leu Ala Asp Leu Ser Ile 
        35                  40                  45              


Asn Phe Ser Val Ser Tyr Asn Val Ser Ser Lys Met Glu Leu Ala Thr 
    50                  55                  60                  


Phe Val Leu Pro Ser Glu Ala Val Thr Asn Ile Asn Lys Ser Ser Cys 
65                  70                  75                  80  


Gly Val Glu Asn Thr Thr Ala Pro Val Leu Ala Ile Gln Phe Gly Ser 
                85                  90                  95      


Asn His Ser Leu Ser Ile His Phe Ala Arg Asn Asn Thr Arg Tyr Glu 
            100                 105                 110         


Val Ala Glu Leu Val Met Ser Tyr Asn Leu Ser Asp Lys Ile Ile Phe 
        115                 120                 125             


Pro Asn Ala Ser Glu Asn Gly Thr Lys Thr Val Ser Thr Asn Lys Thr 
    130                 135                 140                 


Ala Val Leu Ala Glu Asn Asp Thr Val Tyr Lys Cys Met Asn Pro His 
145                 150                 155                 160 


Leu Ile Arg Met Asp Asn Ala Asn Ala Thr Phe His Asp Ile Arg Leu 
                165                 170                 175     


Glu Ala Tyr Leu Lys Gln Ser Asn Phe Ser Gln Lys Val Ser Thr Cys 
            180                 185                 190         


Ser Glu Asp Ile Thr Pro Thr Ser Ala Pro Ala Pro Val Thr Thr Thr 
        195                 200                 205             


Ala Pro Val Pro Ala Pro Val Pro Asp Pro Pro Val Val Gln Tyr Ser 
    210                 215                 220                 


Val Asn Arg Ser Ser Glu Pro Cys Leu Leu Ala Lys Val Gly Leu Gln 
225                 230                 235                 240 


Met Asn Ile Thr Tyr Thr Thr Lys Asp Gly Lys Asn Gly Ser Tyr Val 
                245                 250                 255     


Phe Asn Ile Glu Ser Lys Gly Val Thr Val Asp Gly Asn Cys Thr Asn 
            260                 265                 270         


Thr Thr Ala Tyr Leu Ser Leu Ser Thr Gly Ser Ile Asp Leu Arg Phe 
        275                 280                 285             


Asn Phe Thr Leu Asn Ser Ser Leu Glu Val Phe Tyr Leu Asp Gly Val 
    290                 295                 300                 


Ser Leu Ser Thr Gly Leu Pro Ala Asp Ala Asn Asp Thr His Phe Glu 
305                 310                 315                 320 


Ala Ala Asn Ser Ser Leu Asn Tyr Met Gln Thr Asn Val His Lys Ser 
                325                 330                 335     


Phe Lys Cys Asn Ser Lys Gln Thr Leu Gln Ile Thr Asp Pro Phe Thr 
            340                 345                 350         


Val Asn Thr Tyr His Leu Gln Val Gln Ala Phe Asn Ser Asp Asn Thr 
        355                 360                 365             


Phe Ala Ser Ala Val Glu Cys Ser Leu Asp Glu Asn Gly Met Leu Val 
    370                 375                 380                 


Pro Ile Val Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  9
<211>  417
<212>  PRT
<213>  Pan troglodytes

<400>  9

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ser Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Glu Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Ser Thr Val Leu Leu Phe 
        275                 280                 285             


Leu Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Thr Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Val Leu Asp Glu Asn Asn Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  10
<211>  415
<212>  PRT
<213>  Macaca mulatta

<400>  10

Met Ala Ala Pro Gly Ser Ala Arg Arg Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Thr His Cys Ala Ser Ala Ala Met Phe Ile Val 
            20                  25                  30          


Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala 
        35                  40                  45              


Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Phe 
    50                  55                  60                  


Asp Leu Pro Ser Asp Ala Lys Val Val Leu Asn Ser Ser Ser Cys Gly 
65                  70                  75                  80  


Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly 
                85                  90                  95      


Gln Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val 
            100                 105                 110         


Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro 
        115                 120                 125             


Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile 
    130                 135                 140                 


Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val 
145                 150                 155                 160 


His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala 
                165                 170                 175     


Tyr Leu Ser Asn Ser Ser Phe Ser Arg Glu Glu Thr Arg Cys Glu Gln 
            180                 185                 190         


Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser 
        195                 200                 205             


Pro Ser Pro Val Pro Glu Ser Pro Ser Val Asp Lys Tyr Asn Val Ser 
    210                 215                 220                 


Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn 
225                 230                 235                 240 


Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn 
                245                 250                 255     


Ile Asn Pro Asn Lys Thr Leu Ala Ser Gly Ser Cys Gly Ala His Leu 
            260                 265                 270         


Val Thr Leu Glu Leu His Ser Glu Gly Ser Thr Val Leu Leu Phe Gln 
        275                 280                 285             


Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln 
    290                 295                 300                 


Leu Asn Thr Thr Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala 
305                 310                 315                 320 


Asn Ser Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys 
                325                 330                 335     


Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn 
            340                 345                 350         


Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe 
        355                 360                 365             


Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Asn Met Leu Ile Pro 
    370                 375                 380                 


Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile 
385                 390                 395                 400 


Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415 


<210>  11
<211>  413
<212>  PRT
<213>  Canis lupus familiaris

<400>  11

Met Ala Ala Phe Gly Gly Ala Arg Pro Arg Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Val His Gly Ala Ala Ala Val Phe Val Val Lys Asp 
            20                  25                  30          


Ala Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala Phe Leu 
        35                  40                  45              


Ala Ser Tyr Glu Thr Arg Ser Gly Pro Lys Asn Val Thr Phe Asp Leu 
    50                  55                  60                  


Pro Ser Asp Ala Val Val Leu Asn Ser Ser Ser Cys Gly Lys Glu Asn 
65                  70                  75                  80  


Thr Ser Asp Pro Ser Leu Met Ile Ala Phe Gly Lys Gly His Gly Leu 
                85                  90                  95      


Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val Gln Leu Met 
            100                 105                 110         


Ser Phe Ile Tyr Asn Leu Ser Asp Thr Gln Ile Phe Pro Asn Ala Ser 
        115                 120                 125             


Ser Lys Glu Thr Lys Thr Val Glu Ser Ala Thr Asp Ile Arg Ala Asp 
    130                 135                 140                 


Ile Asn Lys Lys Tyr Arg Cys Val Ser Asn Thr Gln Ile His Met His 
145                 150                 155                 160 


Asn Val Thr Val Thr Phe His Asp Val Thr Ile Gln Ala Tyr Leu Ala 
                165                 170                 175     


Asn Ser Asn Phe Ser Lys Glu Glu Thr Arg Cys Glu Gln Asp Gly Pro 
            180                 185                 190         


Phe Pro Thr Thr Ala Pro Pro Pro Pro Pro His Pro Ser Pro Ser Pro 
        195                 200                 205             


Ala Pro Glu Ser Pro Ser Val His Lys Tyr Asn Val Ser Gly Ala Asn 
    210                 215                 220                 


Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn Val Thr Tyr 
225                 230                 235                 240 


Lys Lys Lys Asp Asn Thr Thr Val Val Lys Val Val Ser Ile Asn Pro 
                245                 250                 255     


Asn Lys Thr Thr Ala Gly Gly Ser Cys Gly Ala Gln Leu Val Thr Leu 
            260                 265                 270         


Glu Leu Arg Ser Glu Ser Val Thr Leu Leu Ala Phe Gln Phe Gly Met 
        275                 280                 285             


Asn Ala Ser Thr Ser Arg Phe Phe Leu Gln Gly Ile Gln Leu Asn Met 
    290                 295                 300                 


Thr Leu Pro Asp Ala Arg Asp Pro Thr Phe Lys Ala Gly Asn Asn Ser 
305                 310                 315                 320 


Leu Arg Ala Leu Gln Ala Thr Ile Gly Asn Ser Tyr Lys Cys Asn Ala 
                325                 330                 335     


Gly Glu His Val Gln Val Thr Glu Ala Phe Ser Val Asn Ile Ile Lys 
            340                 345                 350         


Val Trp Val Gln Ala Phe Gln Val Gln Gly Asp Lys Phe Gly Ser Val 
        355                 360                 365             


Glu Glu Cys Gln Leu Asp Glu Asn Ser Met Leu Ile Pro Ile Ala Val 
    370                 375                 380                 


Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile Ala Tyr Leu 
385                 390                 395                 400 


Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 410             


<210>  12
<211>  417
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Met Glu Ala Pro Gly Gly Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Val His Gly Ala Ser Ala Val Phe Val Val Arg Asn Ser 
            20                  25                  30          


Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Val Phe Ser Val 
        35                  40                  45              


Ile Tyr Glu Ser Lys Ser Gly Tyr Lys Asn Ala Ser Phe Glu Leu Pro 
    50                  55                  60                  


Ala Thr Ala Glu Val Gln Asn Thr Ser Ser Cys Gly Arg Glu Asn Thr 
65                  70                  75                  80  


Ser Asn Pro Ser Leu Gln Ile Ala Phe Gly Arg Gly His Val Leu Ala 
                85                  90                  95      


Leu Asn Phe Thr Arg Asn Ala Thr Leu Tyr Ser Val Pro Leu Leu Ser 
            100                 105                 110         


Phe Val Tyr Asn Leu Ser Asp Ser Asp Leu Phe Pro Asn Ala Ser Ser 
        115                 120                 125             


Lys Asp Ile Lys Thr Val Gly Ser Thr Thr Asp Ile Lys Ala Asp Ile 
    130                 135                 140                 


Asp Lys Arg Tyr Arg Cys Val Ser Asp Ser Lys Val Pro Met Gly Asn 
145                 150                 155                 160 


Val Thr Val Thr Leu Gln Asp Ala Thr Ile Gln Ala Tyr Leu Trp Asn 
                165                 170                 175     


Asn Ser Phe Ser Gln Ala Glu Ser Arg Cys Arg Gln Asp Met Pro Ser 
            180                 185                 190         


Pro Thr Thr Ala Pro Pro Ala Pro Pro Val Pro Pro Ser Pro Pro Ser 
        195                 200                 205             


Pro Ser Pro Pro Pro Lys Pro Glu Ser Pro Ser Val Ser Arg Tyr Asn 
    210                 215                 220                 


Val Ser Asp Gly Asn Ala Thr Cys Leu Leu Ala Ser Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Leu Thr Tyr Val His Arg Asp Asn Ala Thr Val Thr Arg Val 
                245                 250                 255     


Phe Asn Ile Asn Pro Asn Lys Thr Lys Pro Ser Gly His Cys Gly Ala 
            260                 265                 270         


Gln Gln Val Thr Leu Glu Leu Gln Ser Glu Arg Ser Thr Val Leu Val 
        275                 280                 285             


Phe Gln Phe Gly Met Asn Ala Ser Ser Gly Gln Tyr Phe Leu Gln Gly 
    290                 295                 300                 


Val Leu Leu Asn Thr Thr Leu Pro Asp Ala Arg Glu Pro Ala Phe Ser 
305                 310                 315                 320 


Ala Ser Asn Ser Ser Leu Arg Ala Leu Gln Ala Thr Leu Gly Asn Ser 
                325                 330                 335     


Tyr Lys Cys Asn Ser Glu Glu His Val Arg Val Thr Pro Ala Phe Ser 
            340                 345                 350         


Leu Ser Ile Phe Lys Val Trp Val Gln Ala Phe Gln Val Lys Gly Asp 
        355                 360                 365             


Lys Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Gln Asp Ser Met Leu 
    370                 375                 380                 


Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Val Val 
385                 390                 395                 400 


Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln 
                405                 410                 415     


Thr 
    


<210>  13
<211>  409
<212>  PRT
<213>  Bos taurus

<400>  13

Met Ala Ala Pro Gly Gly Ala Arg Arg Arg Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ala Gly Leu Val His Gly Ala Ser Ala Val Phe Val Val Lys Asn 
            20                  25                  30          


Gly Asn Gly Thr Ala Cys Ile Met Ala Asp Phe Ser Ala Thr Phe Leu 
        35                  40                  45              


Thr Ser Tyr Asp Thr Arg Ser Gly Pro Gln Asn Lys Ser Phe Glu Leu 
    50                  55                  60                  


Pro Ala Gly Ala Glu Val Ser Asn Ser Ser Ser Cys Gly Lys Glu Asn 
65                  70                  75                  80  


Ala Ser Asp Ser Ser Leu Val Ile Thr Phe Gly Arg Gly His Thr Leu 
                85                  90                  95      


Thr Leu Ile Phe Thr Arg Asn Ala Thr Arg Tyr Glu Val Gln Leu Met 
            100                 105                 110         


Arg Phe Ala Tyr Asn Leu Ser Asp Thr Asp Thr Phe Pro Asn Ser Ser 
        115                 120                 125             


Ser Thr Gly Val Lys Thr Val Glu Ser Ala Thr Asp Ile Lys Ala Asp 
    130                 135                 140                 


Ile Asn Lys Thr Tyr Arg Cys Val Ser Glu Thr Gln Val Asn Met Asp 
145                 150                 155                 160 


Asn Val Thr Val Thr Leu Arg Asp Ala Ala Ile Gln Ala Tyr Leu Ser 
                165                 170                 175     


Ser Ser Asn Phe Ser Arg Glu Glu Thr Arg Cys Glu Gln Asp Leu Pro 
            180                 185                 190         


Thr Pro Thr Thr Pro Pro Gln Pro Ala Pro Thr Pro Ala Pro Ala Ser 
        195                 200                 205             


Pro Ala Val Phe Arg Tyr Asn Val Ser Gly Ser Asn Gly Thr Cys Leu 
    210                 215                 220                 


Leu Ala Ser Met Gly Leu Gln Leu Asn Val Thr Tyr Arg Arg Val Asp 
225                 230                 235                 240 


Asn Lys Thr Val Thr Arg Glu Phe Asn Val Asn Pro Asn Lys Thr Thr 
                245                 250                 255     


Phe Gly Gly Asn Cys Ser Ala Thr Leu Ala Thr Leu Glu Leu His Ser 
            260                 265                 270         


Glu Asn Leu Leu Leu Leu Ala Leu Gln Phe Val Met Asn Glu Ser Ser 
        275                 280                 285             


Ser Arg Val Phe Leu Gln Gly Val Gln Leu Asn Leu Thr Leu Pro Asp 
    290                 295                 300                 


Ala Lys Glu Gly Ser Phe Thr Ala Thr Asn Ser Ser Leu Arg Ala Leu 
305                 310                 315                 320 


Gln Ala Thr Ala Gly Asn Ser Tyr Lys Cys Asn Ala Glu Gln Arg Leu 
                325                 330                 335     


Arg Val Thr Ser Ser Phe Ser Leu Asn Met Phe Arg Val Trp Leu Gln 
            340                 345                 350         


Ala Phe Arg Val Asp Gly Asp Lys Phe Gly Pro Val Glu Glu Cys Gln 
        355                 360                 365             


Leu Asp Glu Asn Ser Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu 
    370                 375                 380                 


Ala Gly Leu Val Leu Ile Val Leu Leu Ala Tyr Leu Ile Gly Arg Lys 
385                 390                 395                 400 


Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 


<210>  14
<211>  407
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Ala Ala Pro Gly Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Leu Ala His Ser Ala Pro Ala Leu Phe Glu Val Lys Asp Asn Asn 
            20                  25                  30          


Gly Thr Ala Cys Ile Met Ala Ser Phe Ser Ala Ser Phe Leu Thr Thr 
        35                  40                  45              


Tyr Asp Ala Gly His Val Ser Lys Val Ser Asn Met Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Glu Val Leu Lys Asn Ser Ser Ser Cys Gly Glu Lys Asn Ala 
65                  70                  75                  80  


Ser Glu Pro Thr Leu Ala Ile Thr Phe Gly Glu Gly Tyr Leu Leu Lys 
                85                  90                  95      


Leu Thr Phe Thr Lys Asn Thr Thr Arg Tyr Ser Val Gln His Met Tyr 
            100                 105                 110         


Phe Thr Tyr Asn Leu Ser Asp Thr Gln Phe Phe Pro Asn Ala Ser Ser 
        115                 120                 125             


Lys Gly Pro Asp Thr Val Asp Ser Thr Thr Asp Ile Lys Ala Asp Ile 
    130                 135                 140                 


Asn Lys Thr Tyr Arg Cys Val Ser Asp Ile Arg Val Tyr Met Lys Asn 
145                 150                 155                 160 


Val Thr Ile Val Leu Trp Asp Ala Thr Ile Gln Ala Tyr Leu Pro Ser 
                165                 170                 175     


Ser Asn Phe Ser Lys Glu Glu Thr Arg Cys Pro Gln Asp Gln Pro Ser 
            180                 185                 190         


Pro Thr Thr Gly Pro Pro Ser Pro Ser Pro Pro Leu Val Pro Thr Asn 
        195                 200                 205             


Pro Ser Val Ser Lys Tyr Asn Val Thr Gly Asp Asn Gly Thr Cys Leu 
    210                 215                 220                 


Leu Ala Ser Met Ala Leu Gln Leu Asn Ile Thr Tyr Met Lys Lys Asp 
225                 230                 235                 240 


Asn Thr Thr Val Thr Arg Ala Phe Asn Ile Asn Pro Ser Asp Lys Tyr 
                245                 250                 255     


Ser Gly Thr Cys Gly Ala Gln Leu Val Thr Leu Lys Val Gly Asn Lys 
            260                 265                 270         


Ser Arg Val Leu Glu Leu Gln Phe Gly Met Asn Ala Thr Ser Ser Leu 
        275                 280                 285             


Phe Phe Leu Gln Gly Val Gln Leu Asn Met Thr Leu Pro Asp Ala Ile 
    290                 295                 300                 


Glu Pro Thr Phe Ser Thr Ser Asn Tyr Ser Leu Lys Ala Leu Gln Ala 
305                 310                 315                 320 


Ser Val Gly Asn Ser Tyr Lys Cys Asn Ser Glu Glu His Ile Phe Val 
                325                 330                 335     


Ser Lys Ala Leu Ala Leu Asn Val Phe Ser Val Gln Val Gln Ala Phe 
            340                 345                 350         


Arg Val Glu Ser Asp Arg Phe Gly Ser Val Glu Glu Cys Val Gln Asp 
        355                 360                 365             


Gly Asn Asn Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly 
    370                 375                 380                 


Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser 
385                 390                 395                 400 


His Ala Gly Tyr Gln Thr Ile 
                405         


<210>  15
<211>  414
<212>  PRT
<213>  Gallus gallus

<400>  15

Met Gly Gly Ala Ala Arg Ala Val Leu Leu Gly Phe Leu Gln Ala Ser 
1               5                   10                  15      


Ser Ser Phe Asp Val Arg Asp Ser Thr Gly Lys Val Cys Ile Ile Ala 
            20                  25                  30          


Asn Leu Thr Val Ala Phe Ser Val Glu Tyr Lys Ser Ser Gly Gln Lys 
        35                  40                  45              


Gln Phe Ala His Phe Phe Leu Pro Gln Asn Ala Thr Ser Gln Ser His 
    50                  55                  60                  


Ser Ser Cys Gly Glu Gly Asn Thr Ser His Pro Ile Leu Ala Leu Ser 
65                  70                  75                  80  


Phe Gly Ala Gly His Leu Ile Ser Leu Asn Phe Ser Lys Thr Leu Asp 
                85                  90                  95      


Lys Tyr Gln Val Glu Glu Leu Thr Phe His Tyr Asn Leu Ser Asp Glu 
            100                 105                 110         


Thr Leu Phe Pro Asn Ala Thr Glu Gly Lys Val Met Val Ala Thr Gln 
        115                 120                 125             


Lys Ser Val Ile Gln Ala Arg Ile Gly Thr Glu Tyr Arg Cys Ile Asn 
    130                 135                 140                 


Ser Lys Tyr Val Arg Met Lys His Val Asn Ile Thr Phe Ser Asn Val 
145                 150                 155                 160 


Thr Leu Glu Ala Tyr Pro Thr Asn Asp Thr Phe Ser Ala Asn Lys Thr 
                165                 170                 175     


Glu Cys Arg Glu Asp Met Val Ser Thr Thr Thr Val Ala Pro Thr Thr 
            180                 185                 190         


Pro Lys His Ala Thr Ser Gln Val Pro Thr Thr Ser Pro Ala Pro Thr 
        195                 200                 205             


Ala Ala Pro Ser Ser Pro Ala Val Gly Lys Tyr Asn Val Thr Gly Ala 
    210                 215                 220                 


Asn Gly Thr Cys Val Leu Ala Ser Met Gly Leu Gln Leu Asn Ile Thr 
225                 230                 235                 240 


Tyr Val Lys Lys Asp Glu Lys Met Gly Leu Asp Leu Leu Asn Phe Ile 
                245                 250                 255     


Pro His Asn Thr Ser Ala Ser Gly Met Cys Glu Ser Thr Ser Ala Phe 
            260                 265                 270         


Leu Asn Leu Ala Phe Glu Lys Thr Lys Ile Thr Phe His Phe Val Leu 
        275                 280                 285             


Asn Ala Ser Ser Glu Lys Phe Phe Leu Gln Gly Val Asn Val Ser Thr 
    290                 295                 300                 


Thr Leu Pro Ser Glu Ala Lys Ala Pro Thr Phe Glu Ala Ser Asn Asp 
305                 310                 315                 320 


Ser Met Ser Glu Ser Arg Ala Thr Val Gly Asn Ser Tyr Lys Cys Ser 
                325                 330                 335     


Ala Glu Glu Asn Phe Gln Val Thr Asp Lys Ala Leu Val Asn Val Phe 
            340                 345                 350         


Asn Val Gln Val Gln Ala Phe Lys Val Asp Gly Asp Lys Phe Gly Ala 
        355                 360                 365             


Met Glu Glu Cys Gln Leu Asp Glu Asn Asn Met Leu Ile Pro Ile Ile 
    370                 375                 380                 


Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile Ala Tyr 
385                 390                 395                 400 


Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 410                 


<210>  16
<211>  413
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Ala Ala Pro Gly Gly Ala Trp Arg Arg Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ala Arg Gly Ala Ser Ala Val Phe Val Val Ser 
            20                  25                  30          


Asp Gly Asn Gly Thr Ala Cys Ile Met Ala Asp Phe Ala Ala Ala Phe 
        35                  40                  45              


Glu Ile Ser Tyr Asp Ser Arg Ser Gly Ala Lys Asn Thr Thr Phe Ser 
    50                  55                  60                  


Leu Pro Ala Ser Ala Gln Val Leu Asn Ser Ser Ser Cys Gly Lys Glu 
65                  70                  75                  80  


Asn Thr Ser Asp Ser Ser Leu Val Ile Ala Phe Gly Arg Gly His Thr 
                85                  90                  95      


Leu Thr Leu Ser Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val Gln Leu 
            100                 105                 110         


Met Thr Leu Val Tyr Asn Leu Ser Asp Ala Glu Phe Phe Pro Ser Ala 
        115                 120                 125             


Ser Ser Lys Gly Thr Lys Thr Val Ala Ala Ser Thr Asp Ile Arg Ala 
    130                 135                 140                 


Asp Leu Asn Thr Lys Tyr Arg Cys Val Ser Asn Ser Gln Val His Leu 
145                 150                 155                 160 


Leu Asn Val Thr Val Thr Leu Gly Asn Ala Thr Ile Gln Ala Tyr Leu 
                165                 170                 175     


Ala Asn Asn Ser Phe Ser Gln Gln Glu Thr Arg Cys Glu Gln Asp Lys 
            180                 185                 190         


Pro Ser Pro Pro Thr Pro Thr Ala Pro Pro Thr Pro Thr Pro Thr Pro 
        195                 200                 205             


Ala Pro Thr Ser Pro Val Val Ser Arg Tyr Asn Val Ser Gly Ala Asn 
    210                 215                 220                 


Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn Val Thr Tyr 
225                 230                 235                 240 


Arg Thr Lys Asp Asn Thr Thr Val Thr Arg Gly Leu Asn Ile Asn Pro 
                245                 250                 255     


Asn Lys Thr Thr Phe Gly Gly Ser Cys Ser Ala Gln Leu Val Thr Leu 
            260                 265                 270         


Glu Leu Gln Gly Glu Ser Leu Arg Leu Leu Ala Leu Gln Phe Ala Leu 
        275                 280                 285             


Asn Thr Ser Ser Ser Arg Val Phe Leu Gln Gly Val Gln Leu Asn Met 
    290                 295                 300                 


Thr Leu Pro Asp Ala Arg Asp Pro Ser Phe Ser Ala Ala Asn Ser Ser 
305                 310                 315                 320 


Leu Arg Ala Leu Gln Ala Thr Ala Gly Asn Ser Tyr Lys Cys Arg Ser 
                325                 330                 335     


Glu Gln Arg Leu Gln Val Thr Glu Ala Phe Ala Leu Asn Val Phe Gln 
            340                 345                 350         


Val Arg Val Gln Ala Phe Arg Val Asp Gly Asp Lys Phe Gly Pro Ala 
        355                 360                 365             


Glu Glu Cys Gln Leu Asp Glu Asn Ser Met Leu Ile Pro Ile Ala Val 
    370                 375                 380                 


Gly Gly Ala Leu Ala Gly Leu Val Leu Val Val Leu Met Ala Tyr Leu 
385                 390                 395                 400 


Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 410             


<210>  17
<211>  422
<212>  PRT
<213>  Monodelphis domestica

<400>  17

Met Ala Glu Pro Gly Gly Ala Arg Thr Pro Gln Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Leu Ile His Val Ala Ser Ser Ile Phe Val Val Lys Asn 
            20                  25                  30          


Gly Thr Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Thr Phe Ser 
        35                  40                  45              


Met Asn Tyr Thr Thr Lys Ser Gly Leu Glu Ser Thr Thr Phe Arg Leu 
    50                  55                  60                  


Pro Gln Asn Ala Ser Val Met Asn Ser Ser Ser Cys Gly Lys Glu Asn 
65                  70                  75                  80  


Thr Ser Asn Pro Ile Leu Glu Ile Gly Phe Gly Gly Gly His Thr Leu 
                85                  90                  95      


Thr Met Asn Phe Ser Ser Thr Thr Gln Ser Tyr Gln Val Glu Leu Leu 
            100                 105                 110         


Ser Phe Ser Tyr Asn Leu Ser Asp Ala Thr Leu Phe Pro Asn Ala Ser 
        115                 120                 125             


Lys Gly Ser Glu Glu Ser Ser Val Lys Ser Lys Thr Asp Ile Gln Ala 
    130                 135                 140                 


Asp Ile His Lys Lys Tyr Arg Cys Val Ser Ser Asn Arg Ile Thr Met 
145                 150                 155                 160 


Ser Asn Val Thr Ile Val Leu Ser Asp Val Thr Ile Gln Ala Tyr Leu 
                165                 170                 175     


Ser Asn Asn Thr Phe Ser Lys Glu Glu Thr Arg Cys Ser Gln Asp Thr 
            180                 185                 190         


Pro Ser Pro Ser Pro Val Pro Thr Thr His Pro Thr Thr Ile Pro Val 
        195                 200                 205             


Pro Thr Pro Thr Pro Thr Arg Pro Pro Thr Pro Ala Glu Ile Pro Pro 
    210                 215                 220                 


Ile Phe Lys Tyr Asn Val Ser Asp Ala Asn Gly Thr Cys Leu Leu Ala 
225                 230                 235                 240 


Ser Met Gly Leu Gln Leu Asn Ile Thr Tyr Ala Lys Lys Asp Asn Ser 
                245                 250                 255     


Ser Ala Arg Ile Ile Trp Asn Ile Asn Pro Asn Lys Thr Val Ala Gly 
            260                 265                 270         


Gly Ser Cys Ser Pro Gln Val Ala Ile Leu Glu Leu Gln Thr Glu Asn 
        275                 280                 285             


Ser Thr Leu Ala Phe Ser Phe Gly Met Asn Ala Thr Thr Ser Lys Phe 
    290                 295                 300                 


Phe Leu Arg Glu Ile Arg Phe His Lys Phe Phe Pro Asp Ala Lys Asp 
305                 310                 315                 320 


Pro Ala Phe Gly Ala Val Asn Ser Ser Leu Lys Glu Leu Gln Ala Thr 
                325                 330                 335     


Val Gly Asn Ser Tyr Lys Cys Asn Ala Glu Glu Asn Val His Val Thr 
            340                 345                 350         


Asp Gly Phe Ser Val Asn Ile Phe Arg Val Arg Val Gln Ala Phe Lys 
        355                 360                 365             


Val Glu Gly Asp Lys Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu 
    370                 375                 380                 


Asn Asn Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu 
385                 390                 395                 400 


Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His 
                405                 410                 415     


Ala Gly Tyr Gln Thr Ile 
            420         


<210>  18
<211>  415
<212>  PRT
<213>  Meleagris gallopavo

<400>  18

Met Ala Arg Ala Leu Leu Ala Ala Val Leu Leu Gly Phe Leu Gln Ala 
1               5                   10                  15      


Ser Ser Ser Phe Asp Val Arg Asp Ser Thr Gly Lys Val Cys Ile Ile 
            20                  25                  30          


Ala Asn Leu Thr Val Ala Phe Ser Val Glu Tyr Lys Ser Asn Gly Gln 
        35                  40                  45              


Lys Gln Phe Ala His Phe Phe Leu Pro Gln Asn Ala Thr Ser Gln Ser 
    50                  55                  60                  


His Ser Ser Cys Gly Glu Gly Asn Thr Ser His Pro Ile Leu Ala Leu 
65                  70                  75                  80  


Ser Phe Gly Ala Gly His Leu Leu Ser Leu Asn Phe Ser Lys Thr Leu 
                85                  90                  95      


Asp Lys Tyr Gln Val Glu Glu Leu Thr Phe His Tyr Asn Leu Ser Asp 
            100                 105                 110         


Glu Thr Leu Phe Pro Asn Ala Ser Glu Gly Lys Val Met Glu Val Thr 
        115                 120                 125             


Gln Lys Ser Val Ile Gln Ala Arg Ile Gly Thr Glu Tyr Arg Cys Ile 
    130                 135                 140                 


Asn Ser Lys Tyr Ile Tyr Ile Arg His Val Asn Ile Thr Phe Ser Asn 
145                 150                 155                 160 


Val Thr Leu Glu Ala Tyr Pro Thr Asn Gly Thr Phe Ser Thr Asn Lys 
                165                 170                 175     


Thr Glu Cys Ser Glu Asp Met Val Ser Thr Thr Thr Val Ala Pro Thr 
            180                 185                 190         


Thr Pro Lys His Ile Thr Ser Gln Val Pro Ala Thr Ser Pro Ala Pro 
        195                 200                 205             


Thr Ala Ala Pro Ser Asn Pro Ala Val Gly Lys Tyr Asn Val Thr Gly 
    210                 215                 220                 


Ala Asn Gly Thr Cys Val Leu Ala Ser Met Gly Leu Gln Leu Asn Ile 
225                 230                 235                 240 


Thr Tyr Leu Lys Lys Asp Gly Lys Thr Gly Leu Asp Leu Leu Asn Phe 
                245                 250                 255     


Val Pro His Asn Thr Asn Ala Ser Gly Thr Cys Glu Asn Thr Ser Ala 
            260                 265                 270         


Phe Leu Asn Leu Ala Phe Glu Lys Thr Lys Ile Thr Phe His Phe Val 
        275                 280                 285             


Leu Asn Ala Ser Ser Glu Lys Phe Phe Leu Gln Gly Val Asn Val Ser 
    290                 295                 300                 


Thr Thr Leu Pro Ser Glu Ala Lys Ala Pro Met Phe Glu Ala Ser Asn 
305                 310                 315                 320 


Asp Ser Met Ser Glu Leu Arg Ala Thr Val Gly Asn Ser Tyr Lys Cys 
                325                 330                 335     


Ser Ala Glu Glu Asn Leu Gln Val Thr Asp Lys Ala Leu Val Asn Val 
            340                 345                 350         


Phe Asn Val Gln Val Gln Ala Phe Lys Val Asp Gly Asp Lys Phe Gly 
        355                 360                 365             


Ala Val Glu Glu Cys Gln Leu Asp Glu Asn Asn Met Leu Ile Pro Ile 
    370                 375                 380                 


Ile Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile Ala 
385                 390                 395                 400 


Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 410                 415 


<210>  19
<211>  415
<212>  PRT
<213>  Taeniopygia guttata

<400>  19

Met Ala Arg Gly Leu Leu Ala Ala Ala Ala Leu Leu Gly Phe Leu Gln 
1               5                   10                  15      


Ala Ser Ser Ser Phe Glu Val Lys Asp Ser Ser Gly Lys Val Cys Ile 
            20                  25                  30          


Leu Ala Asp Leu Thr Val Ala Phe Ser Val Glu Tyr Lys Thr Asn Val 
        35                  40                  45              


Gln Lys Glu Phe Val His Phe Phe Leu Pro Gln Asn Ala Ser Val Asp 
    50                  55                  60                  


Ser Gln Ser Ser Cys Gly Lys Asp Asn Ala Ser His Pro Ile Leu Val 
65                  70                  75                  80  


Leu Asp Phe Gly Gly Gly His Ser Leu Ser Leu Asn Phe Ser Glu Ser 
                85                  90                  95      


Ala Asp Lys Tyr Gln Val Glu Glu Leu Val Phe His Tyr Asn Leu Ser 
            100                 105                 110         


Asp Ala Thr Leu Phe Pro Asn Ser Ser Thr Gly Gly Met Lys Thr Val 
        115                 120                 125             


Ser His Lys Ser Ile Ile Gln Ala His Met Gly Thr Gln Tyr Arg Cys 
    130                 135                 140                 


Ile Asn Ser Lys His Ile Asn Met Lys Asn Val Asn Val Thr Phe Ser 
145                 150                 155                 160 


Asn Val Thr Leu Glu Ala Tyr Leu Thr Asn Gly Thr Leu Ser Val Asn 
                165                 170                 175     


Lys Thr Glu Cys Ala Glu Asp Arg Val Ser Thr Thr Thr Met Val Pro 
            180                 185                 190         


Thr Thr Pro Lys Gln Thr Thr Ser Gln Ser Pro Thr Thr Gly Pro Ala 
        195                 200                 205             


Pro Thr Ser Pro Pro Asn Pro Thr Val Gly Lys Tyr Asn Val Thr Gly 
    210                 215                 220                 


Pro Asn Gly Thr Cys Val Leu Ala Tyr Met Gly Leu Gln Leu Asn Ile 
225                 230                 235                 240 


Thr Tyr Gln Gln Lys Asp Glu Lys Met Gly Leu Asp Leu Leu Asn Phe 
                245                 250                 255     


Val Pro His Asn Thr Thr Ser Ser Gly Arg Cys Asp Asn Thr Ser Ala 
            260                 265                 270         


Leu Leu Asn Leu Thr Phe Glu Lys Thr Arg Val Ile Phe Gln Phe Ala 
        275                 280                 285             


Leu Asn Ala Thr Ala Glu Lys Phe Phe Leu Gln Gly Val Ser Val Ser 
    290                 295                 300                 


Thr Thr Leu Pro Ser Glu Ala Lys Asn Pro Lys Phe Glu Ala Thr Asn 
305                 310                 315                 320 


Asn Ser Met Ser Glu Leu Arg Ala Ser Val Gly Asn Ser Tyr Lys Cys 
                325                 330                 335     


Ser Ser Glu Glu Asn Leu Gln Val Thr Asp Gln Ala Leu Val Asn Val 
            340                 345                 350         


Phe Asn Val Gln Val Gln Ile Phe Lys Ile Asp Gly Asp Lys Phe Gly 
        355                 360                 365             


Pro Val Glu Glu Cys Gln Leu Asp Glu Asn Asn Met Leu Ile Pro Ile 
    370                 375                 380                 


Ile Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile Ala 
385                 390                 395                 400 


Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 410                 415 


<210>  20
<211>  418
<212>  PRT
<213>  Anolis carolinensis

<400>  20

Met Val Ser Ser Ser Ser Cys Arg Arg Gly Leu Leu Leu Ala Ala Val 
1               5                   10                  15      


Leu Leu Gly Phe Leu Gln Ala Ser Ser Thr Phe Glu Val Arg Asp Lys 
            20                  25                  30          


Thr Gly Lys Ile Cys Ile Leu Ala Asn Phe Ser Ala Glu Phe Thr Val 
        35                  40                  45              


Asp Tyr Ser Thr Lys Ala Lys Val Glu Arg Lys Thr Phe Gln Leu Pro 
    50                  55                  60                  


Ser Ser Ala His Ile Asn Lys Glu Ser Ser Ser Cys Gly Lys Glu Lys 
65                  70                  75                  80  


Glu Thr Ser Gln Val Leu Val Val Glu Phe Gly Thr Gly Asn Ser Leu 
                85                  90                  95      


Thr Phe Thr Phe Glu Lys Ser Asn Asp Phe Tyr His Val Ser Asn Leu 
            100                 105                 110         


Thr Phe Ser Tyr Asn Leu Ser Asp Ser Ser Phe Phe Pro Asn Ser Ser 
        115                 120                 125             


Gly Gly Gln Arg Glu Val Ser Arg Ala Gly Asp Ile Gln Ala Asn Ile 
    130                 135                 140                 


Asn Thr Thr Tyr Arg Cys Arg Ser Asn His Arg Val Asn Met Thr Asn 
145                 150                 155                 160 


Val Thr Val Leu Phe Ser Asn Val Thr Leu Glu Ala Tyr Leu Pro Asn 
                165                 170                 175     


Asn Ala Phe Ser Lys Asn Asp Ser Val Cys Ala Glu Asp Lys Thr Ser 
            180                 185                 190         


Thr Val Ala Pro Pro Ile Thr Thr His Ile Pro Thr Thr Thr Ser Leu 
        195                 200                 205             


Ala Pro Pro Thr Pro Pro Pro Thr Asp Thr Pro Lys Ile Gly Arg Tyr 
    210                 215                 220                 


Asn Val Thr Gly Leu His Gly Ile Cys Leu Leu Ala Thr Met Gly Leu 
225                 230                 235                 240 


Gln Val Asn Val Thr Tyr Ser Thr Lys Asn Lys Thr Ser Lys Ser Glu 
                245                 250                 255     


Leu Leu Asn Leu Pro Pro Thr Ala Glu Val Ser Gly Thr Cys Glu Asn 
            260                 265                 270         


Ser Ser Ile Thr Leu Asn Leu Thr Ser Glu Ser Thr Ser Leu Ser Phe 
        275                 280                 285             


Gln Phe Ser Gln Asn Thr Ser Thr Glu Lys Tyr Phe Leu Gln Gly Ile 
    290                 295                 300                 


Ile Val Thr Ala Asn Leu Pro Pro Glu Ala Thr Glu Lys Asn Ile Ser 
305                 310                 315                 320 


Tyr Ser Asn His Thr Leu Asn Ala Leu Lys Thr Ser Val Gly Lys Ser 
                325                 330                 335     


Tyr Lys Cys Ile Ala Glu Glu Ser Ile Trp Ile Ser Gly Lys Ala Ala 
            340                 345                 350         


Val Asn Ile Phe Asn Ile Gln Leu Gln Ala Phe Lys Ile Pro Gly Asp 
        355                 360                 365             


Lys Phe Gly Ala Val Glu Glu Cys Gln Leu Asp Glu Asn Asn Met Leu 
    370                 375                 380                 


Ile Pro Ile Ile Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile Val 
385                 390                 395                 400 


Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln 
                405                 410                 415     


Thr Ile 
        


<210>  21
<211>  418
<212>  PRT
<213>  Oryzias latipes

<400>  21

Met Lys Ser Phe Pro Ser Phe Val Ala Leu Phe Ile Val Cys Ser Ala 
1               5                   10                  15      


Val Leu Ala Asp Thr Gln Ala Val Val Thr Leu Glu Val Lys Glu Gly 
            20                  25                  30          


Asn Ser Thr Cys Ile Lys Ala Glu Phe Ser Ala Val Phe Ser Ile Thr 
        35                  40                  45              


Tyr Asn Thr Thr Asn Asp Thr Arg Thr Val Ser Val Phe Leu Pro Asn 
    50                  55                  60                  


Ser Thr Thr Val Asp Ser Ala Asn Ser Ser Cys Gly Ser Asn Gly Ser 
65                  70                  75                  80  


Thr Pro Gly Leu Met Ala Lys Phe Gly Pro Gly His Tyr Phe Gly Met 
                85                  90                  95      


Asn Phe Ser Thr Asn Gly Ser Leu Tyr Ser Val Asp Thr Leu Phe Leu 
            100                 105                 110         


Arg Tyr Asn Leu Ser Asp Ala Ser Leu Phe Pro Glu Ala Asn Ser Ser 
        115                 120                 125             


Gly Pro Val Asp Phe Glu Leu Ser Ala Ser Val Gly Ile Trp Ala Pro 
    130                 135                 140                 


Thr Asn Thr Thr Tyr Arg Cys Leu Ser Pro Thr Thr Ile Thr Ile Thr 
145                 150                 155                 160 


Arg Pro Ser Val Thr Phe Ser Glu Met Lys Leu Glu Ala Tyr Met Pro 
                165                 170                 175     


Gly Asn Asp Phe Ser Pro Ala Glu Arg Val Cys Ala Ala Asp Gln Thr 
            180                 185                 190         


Thr Thr Gly Ala Pro Thr Thr Thr Thr Ser Ala Ala Thr Pro Thr Thr 
        195                 200                 205             


Pro Ser Pro Thr Pro Ala Gly Thr Pro Glu Gln Gly Ser Tyr Ser Val 
    210                 215                 220                 


Lys Asn Ala Ser Gly Thr Val Cys Leu Met Ala Lys Met Gly Val Gln 
225                 230                 235                 240 


Leu Asn Val Ser Tyr Phe Ser Gln Ser Gln Asn Lys Thr Val Gln Glu 
                245                 250                 255     


Leu Leu Asn Leu Thr Pro Asn Leu Thr Ser Ser Ser Gly Leu Cys Gly 
            260                 265                 270         


Gly Thr Asn Ala Thr Leu Val Leu Ala Gln Glu Glu Thr Thr Val Leu 
        275                 280                 285             


Ser Phe Leu Phe Thr Val Asn Ser Thr Ser Asn Lys Tyr His Leu Ser 
    290                 295                 300                 


Gly Ile Thr Leu Gln Ala Asn Trp Thr Asp Met Met Ser Pro Phe Ser 
305                 310                 315                 320 


Ala Ser Asn Thr Ser Leu Asp Tyr Leu Arg Ser Ser Leu Gly His Ser 
                325                 330                 335     


Tyr Met Cys Asn Ala Glu Gln Thr Leu Phe Val Val Ser Thr Phe Ser 
            340                 345                 350         


Ile Asn Met Phe Glu Leu Gln Val Gln Pro Phe Gly Val Thr Ser Thr 
        355                 360                 365             


Gln Phe Ala Ser Ala Glu Val Cys Gln Ile Asp Gln Asp Gln Met Leu 
    370                 375                 380                 


Ile Pro Ile Ile Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile Val 
385                 390                 395                 400 


Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr Gln 
                405                 410                 415     


Thr Ile 
        


<210>  22
<211>  420
<212>  PRT
<213>  Takifugu rubripes

<400>  22

Met Lys Arg Ser His Ala Leu Val Val Leu Ile Ile Ala Trp Phe Ser 
1               5                   10                  15      


Leu Ser Gly Cys Ile Gln Ala Val Ser Leu Glu Val Lys Glu Gly Asn 
            20                  25                  30          


Ser Thr Cys Ile Lys Ala Asn Leu Ser Ala Tyr Phe Ser Ile Thr Tyr 
        35                  40                  45              


Asn Thr Ser Ser Ser Thr Arg Thr Ala Gln Phe Ile Leu Pro Asp Ser 
    50                  55                  60                  


Ala Thr Val Asp Pro Asp Ser Ser Thr Cys Gly Gly Asn Gly Ser Ser 
65                  70                  75                  80  


Pro Trp Leu Val Ala Val Phe Gly Ala Gly His Ala Leu Gly Leu Gly 
                85                  90                  95      


Phe Ser Thr Asn Gly Ser Phe Tyr Ser Val Ala Asn Leu Thr Leu Gln 
            100                 105                 110         


Tyr Asn Leu Ser Asp Ala Ser Val Phe Pro Asp Ala Asn Ser Ser Gly 
        115                 120                 125             


Val Val Thr Val Val Ser Ser Ser Val Gly Ile Trp Ala Ala Val Asn 
    130                 135                 140                 


Thr Thr Tyr Arg Cys Leu Ser Ser Val Leu Phe Gln Val Gly Gly Ala 
145                 150                 155                 160 


Thr Val Thr Phe Ser Asp Met Arg Leu Glu Ala Tyr Met Pro Gly Asn 
                165                 170                 175     


Asp Leu Ser Pro Arg Glu Ser Phe Cys Ala Ala Asp Gln Thr Thr Thr 
            180                 185                 190         


Ala Pro Pro Thr Thr Thr Ala Ala Pro Thr Thr Thr Ala Ala Thr Thr 
        195                 200                 205             


Met Ala Pro Pro Ala Pro Thr Pro Pro Gly Thr Pro Val Arg Gly Thr 
    210                 215                 220                 


Tyr Ser Val Val Asn Gly Asn Asp Thr Thr Cys Leu Leu Ala Gln Met 
225                 230                 235                 240 


Gly Leu Gln Leu Asn Val Ser Tyr Phe Ser Arg Ser Gln Asn Lys Thr 
                245                 250                 255     


Val Gln Ser Leu Val Asn Leu Thr Pro Asn Leu Thr Asn Ser Thr Gly 
            260                 265                 270         


Ser Cys Glu Lys Gly Ser Ala Thr Leu Ile Leu Thr Gln Gln Thr Thr 
        275                 280                 285             


Ile Leu Ile Phe Thr Phe Ser Leu Asn Ser Thr Ser Ser Lys Tyr His 
    290                 295                 300                 


Leu Ser Gly Leu Ser Leu Gln Ala Asn Trp Ser Asp Met Ala Ala Ala 
305                 310                 315                 320 


Phe Ser Ala Ser Asn Ala Ser Leu Ser Tyr Leu Arg Ser Thr Phe Gly 
                325                 330                 335     


His Ser Tyr Met Cys Asn Ala Glu Gln Ile Leu Ala Val Thr Pro Val 
            340                 345                 350         


Phe Ser Leu Asn Thr Phe Ser Leu Gln Ile Gln Pro Phe Gly Val Thr 
        355                 360                 365             


Thr Asn Gln Phe Ala Ala Ala Glu Glu Cys Gln Met Asp Gln Asp Gln 
    370                 375                 380                 


Met Leu Ile Pro Ile Ile Val Gly Ala Ser Leu Ala Gly Leu Val Leu 
385                 390                 395                 400 


Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Lys Ser His Ala Gly 
                405                 410                 415     


Tyr Gln Thr Ile 
            420 


<210>  23
<211>  419
<212>  PRT
<213>  Salmo salar

<400>  23

Met Thr Arg Thr Cys Pro Phe Val Val Gly Ile Ala Cys Phe Ala Ile 
1               5                   10                  15      


Leu Gly Cys Val Thr Val Val Gln Ser Gln Val Thr Leu Glu Val Thr 
            20                  25                  30          


Glu Gly Asn Ser Thr Cys Ile Lys Ala Glu Leu Ser Ala Ser Phe Ser 
        35                  40                  45              


Ile Thr Tyr Asp Thr Ala Asn Gly Thr Arg Thr Val Met Val Pro Leu 
    50                  55                  60                  


Pro Gly Ser Ala Val Val Gly Val Ala Ser Ser Cys Gly Gly Asp Gly 
65                  70                  75                  80  


Arg Ser Pro Trp Leu Val Ala Leu Phe Gly Asp Gly His Ala Leu Gly 
                85                  90                  95      


Leu Gly Phe Ser Ser Asn Asp Ser Leu Tyr Ser Val Ala Lys Leu Thr 
            100                 105                 110         


Leu Gln Tyr Asn Leu Ser Asp Val Ser Asn Phe Pro Glu Ala Asn Ser 
        115                 120                 125             


Thr Asp Val Val Thr Val Glu Thr Thr Ser Val Gly Met Val Ala Arg 
    130                 135                 140                 


Val Asn Thr Thr Tyr Arg Cys Ile Ser Ala Ser Pro Val Ile Val Gly 
145                 150                 155                 160 


Gly Ala Thr Val Thr Phe Ser Asn Val Thr Met Glu Ala Phe Met Thr 
                165                 170                 175     


Gly Glu Asp Leu Ser Pro Asn Glu Ser Val Cys Thr Ala Asp Gln Ser 
            180                 185                 190         


Phe Thr Thr Ala Pro Pro Pro Pro Pro Ser Thr Thr Thr Ala Ala Pro 
        195                 200                 205             


Ala Pro Val Pro Thr Pro Pro Gly Thr Pro Ser Gln Gly Ser Tyr Ser 
    210                 215                 220                 


Val Ser Asn Ser Asn Gly Thr Val Cys Leu Leu Ala Arg Met Ala Leu 
225                 230                 235                 240 


Gln Leu Asn Ile Ser His Phe Ser Ala Ser Gln Asn Lys Thr Ile Gln 
                245                 250                 255     


Glu Val Val Asn Leu Leu Pro Asn Gln Thr Thr Ser Ser Gly Ser Cys 
            260                 265                 270         


Asp Pro Thr Ser Ala Thr Leu Val Leu Thr Gln Ala Asn Ala Thr Asn 
        275                 280                 285             


Leu Ser Phe Leu Phe Thr Leu Asn Ser Thr Ser Asn Arg Tyr His Leu 
    290                 295                 300                 


Thr Gly Leu Ser Val Val Ala Ala Trp Ser Asp Met Thr Ala Pro Phe 
305                 310                 315                 320 


Asn Thr Ser Asn Ser Ser Leu Asp Tyr Gln Arg Gly Ser Leu Gly Arg 
                325                 330                 335     


Ser Tyr Met Cys Ile Ser Glu Gln Thr Leu Val Val Asp Gln Asn Phe 
            340                 345                 350         


Ser Leu Asn Thr Phe Gln Leu Gln Val Gln Pro Phe Gly Ile Thr Arg 
        355                 360                 365             


Gly Gln Phe Ala Gln Ala Glu Glu Cys Gln Leu Asp Gln Asp Asn Met 
    370                 375                 380                 


Leu Ile Pro Ile Val Val Gly Ala Ala Leu Ala Gly Leu Val Leu Ile 
385                 390                 395                 400 


Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His Ala Gly Tyr 
                405                 410                 415     


Gln Thr Ile 
            


<210>  24
<211>  247
<212>  PRT
<213>  Oreochromis niloticus

<400>  24

Met Val Gln Ile Cys Arg Val Gln Ser Trp Phe Val Gly Val Thr Pro 
1               5                   10                  15      


Leu Leu Ile Phe Ala Thr Val Leu His Gln Gly Phe Ala Thr Val Ala 
            20                  25                  30          


Pro Pro Thr Pro Ala Pro His Lys Glu Pro Gly Arg Pro Glu Arg Gly 
        35                  40                  45              


Tyr Tyr Asn Val Thr Asn His Asn Gly Thr Ile Cys Leu Met Ala Tyr 
    50                  55                  60                  


Met Gly Leu Gln Leu Asn Ile Ser Tyr Asn Ser Thr Ser Gln Lys Lys 
65                  70                  75                  80  


Val Val Gln Asp Val Met Asn Leu Gln Pro Asn Leu Thr Lys His Ser 
                85                  90                  95      


Gly Leu Cys Asp Ser Asp Ile Ala Ser Leu Asn Leu Thr Val Asp Ala 
            100                 105                 110         


Val Lys Thr Asn Leu Thr Phe Val Phe Thr Met Asn Ser Thr Ser Asn 
        115                 120                 125             


Lys Tyr His Leu Ser Glu Val Thr Val Ser Ala Ala Trp Pro Glu Met 
    130                 135                 140                 


Lys Glu Pro Val Ser Val His Asn Ser Ser Leu Asp Tyr Leu Arg Gly 
145                 150                 155                 160 


Thr Val Gly Tyr Ser Tyr Phe Cys Arg Asp Glu Gln Thr Leu Asn Val 
                165                 170                 175     


Ala Gln Asn Leu Ser Ile Asn Thr Phe Gln Leu Gln Val Gln Pro Phe 
            180                 185                 190         


Ala Val Lys Gly Asp Gln Phe Gly Ala Ala Glu Glu Cys Gln Leu Asp 
        195                 200                 205             


Glu Asp Asp Met Leu Ile Pro Ile Val Val Gly Ala Ala Leu Ala Gly 
    210                 215                 220                 


Leu Val Val Ile Val Leu Leu Ala Tyr Leu Ile Gly Arg Lys Arg Ser 
225                 230                 235                 240 


His Ala Gly Tyr Gln Ser Ile 
                245         


<210>  25
<211>  415
<212>  PRT
<213>  Mus musculus

<400>  25

Met Cys Leu Ser Pro Val Lys Gly Ala Lys Leu Ile Leu Ile Phe Leu 
1               5                   10                  15      


Phe Leu Gly Ala Val Gln Ser Asn Ala Leu Ile Val Asn Leu Thr Asp 
            20                  25                  30          


Ser Lys Gly Thr Cys Leu Tyr Ala Glu Trp Glu Met Asn Phe Thr Ile 
        35                  40                  45              


Thr Tyr Glu Thr Thr Asn Gln Thr Asn Lys Thr Ile Thr Ile Ala Val 
    50                  55                  60                  


Pro Asp Lys Ala Thr His Asp Gly Ser Ser Cys Gly Asp Asp Arg Asn 
65                  70                  75                  80  


Ser Ala Lys Ile Met Ile Gln Phe Gly Phe Ala Val Ser Trp Ala Val 
                85                  90                  95      


Asn Phe Thr Lys Glu Ala Ser His Tyr Ser Ile His Asp Ile Val Leu 
            100                 105                 110         


Ser Tyr Asn Thr Ser Asp Ser Thr Val Phe Pro Gly Ala Val Ala Lys 
        115                 120                 125             


Gly Val His Thr Val Lys Asn Pro Glu Asn Phe Lys Val Pro Leu Asp 
    130                 135                 140                 


Val Ile Phe Lys Cys Asn Ser Val Leu Thr Tyr Asn Leu Thr Pro Val 
145                 150                 155                 160 


Val Gln Lys Tyr Trp Gly Ile His Leu Gln Ala Phe Val Gln Asn Gly 
                165                 170                 175     


Thr Val Ser Lys Asn Glu Gln Val Cys Glu Glu Asp Gln Thr Pro Thr 
            180                 185                 190         


Thr Val Ala Pro Ile Ile His Thr Thr Ala Pro Ser Thr Thr Thr Thr 
        195                 200                 205             


Leu Thr Pro Thr Ser Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr 
    210                 215                 220                 


Val Gly Asn Tyr Ser Ile Arg Asn Gly Asn Thr Thr Cys Leu Leu Ala 
225                 230                 235                 240 


Thr Met Gly Leu Gln Leu Asn Ile Thr Glu Glu Lys Val Pro Phe Ile 
                245                 250                 255     


Phe Asn Ile Asn Pro Ala Thr Thr Asn Phe Thr Gly Ser Cys Gln Pro 
            260                 265                 270         


Gln Ser Ala Gln Leu Arg Leu Asn Asn Ser Gln Ile Lys Tyr Leu Asp 
        275                 280                 285             


Phe Ile Phe Ala Val Lys Asn Glu Lys Arg Phe Tyr Leu Lys Glu Val 
    290                 295                 300                 


Asn Val Tyr Met Tyr Leu Ala Asn Gly Ser Ala Phe Asn Ile Ser Asn 
305                 310                 315                 320 


Lys Asn Leu Ser Phe Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys 
                325                 330                 335     


Asn Lys Glu Gln Val Leu Ser Val Ser Arg Ala Phe Gln Ile Asn Thr 
            340                 345                 350         


Phe Asn Leu Lys Val Gln Pro Phe Asn Val Thr Lys Gly Gln Tyr Ser 
        355                 360                 365             


Thr Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile 
    370                 375                 380                 


Ile Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala 
385                 390                 395                 400 


Tyr Leu Ile Gly Arg Arg Lys Thr Tyr Ala Gly Tyr Gln Thr Leu 
                405                 410                 415 


<210>  26
<211>  415
<212>  PRT
<213>  Xenopus laevis

<400>  26

Met Gly Asp Thr Gly Ala Met Glu Arg Cys Ala Cys Pro Ala Ala Val 
1               5                   10                  15      


Leu Leu Leu Ser Leu Val Leu Met Gly Ala Thr Ala Phe Glu Val Glu 
            20                  25                  30          


Ile Lys Asp Asp Lys Asn Ala Thr Cys Ile Tyr Ala Lys Leu Ser Val 
        35                  40                  45              


Asn Ile Thr Val Gln Tyr Glu Thr Asp Thr Ser Ser Ser Lys Asn Ile 
    50                  55                  60                  


Thr Phe Pro Val Pro Ser Asp Val Thr Thr Asn Gly Ser Ser Cys Gly 
65                  70                  75                  80  


Ser Asp Gly Lys Ala Pro Leu Leu Val Ile Asn Phe Gly Asn Ser Gln 
                85                  90                  95      


Ser Trp Ser Leu Asn Phe Thr Arg Asn Asn Ser Thr Tyr Ser Gly Ser 
            100                 105                 110         


Ala Leu Ile Phe Thr Tyr Asn Thr Asn Asp Thr Ile Leu Phe Pro Asp 
        115                 120                 125             


Ala Leu Arg Lys Gly Leu Ile Ser Ser Thr Ala Met Phe Leu Gly Pro 
    130                 135                 140                 


Val Pro Leu Asn Ser Thr Tyr Lys Cys Ile Ser Arg Glu Val Val Val 
145                 150                 155                 160 


Ser Glu Asn Val Thr Gln Ile Ile Tyr Asp Val Lys Leu Glu Ala Phe 
                165                 170                 175     


Met Ala Asn Gly Thr Leu Gly Lys Glu Ile Ile Cys Asp Ala Asp Lys 
            180                 185                 190         


Pro Ser Pro Val Pro Ser Pro Thr Gln Pro Ser Thr Thr Ala Ser Thr 
        195                 200                 205             


Ala Ile Pro Ala Pro Thr Ser Lys Pro Leu Asp Lys Pro Thr Met Gly 
    210                 215                 220                 


Asn Tyr Thr Val Ser Asp Ala Ser Gly Ile Cys Leu Leu Ala Ser Met 
225                 230                 235                 240 


Gly Leu Gln Ile Asn Thr Ser Leu Leu Ser Glu Gly Lys Asn Ile Trp 
                245                 250                 255     


Arg Pro Phe Asn Ile Asp Pro Leu Gly Ile Lys Thr Asn Gly Thr Cys 
            260                 265                 270         


Thr Asn Gln Thr Gly Thr Leu Ile Leu Thr Glu Asn Arg Thr Ile Ile 
        275                 280                 285             


Glu Phe Thr Phe Ala Leu Lys Asn Lys Asn His Phe Tyr Leu Glu Glu 
    290                 295                 300                 


Val Asn Ile Thr Leu Ile Asn Gly Ser Ala Phe Ser Ser Arg Gln Asn 
305                 310                 315                 320 


Gln Asn Leu Ser Thr Trp Glu Ala Ser Val Asp Ser Ser Tyr Met Cys 
                325                 330                 335     


His Lys Glu Gln Gln Ile Lys Val Ser Glu Asp Leu Phe Ile Asn Ala 
            340                 345                 350         


Phe Asp Val Arg Val Gln Pro Phe Gly Val Asn Asn Gly Thr Phe Ala 
        355                 360                 365             


Thr Ala Glu Asp Cys Phe Ala Asp Gln Asn Phe Ile Val Pro Ile Val 
    370                 375                 380                 


Val Gly Ala Ala Leu Gly Val Leu Val Val Leu Val Met Val Ala Tyr 
385                 390                 395                 400 


Phe Ile Gly Arg Arg Lys Gln Ser Ser Ala Gly Tyr Glu Gln Met 
                405                 410                 415 


<210>  27
<211>  355
<212>  PRT
<213>  Danio rerio

<400>  27

Met Ala Val Arg Gly Phe Leu Pro Leu Leu Phe Ile Leu Leu Ser Gly 
1               5                   10                  15      


Ile Val His Ala Asp Asp Met Met Thr Ser Pro Leu Pro Ser Thr Ala 
            20                  25                  30          


Glu Leu Lys Thr Ala Asn Leu Pro Leu Val Ile Gln Thr Thr Ser Ser 
        35                  40                  45              


Thr Thr Ser Thr Thr Thr Thr Ser Arg Pro Ser Ser Thr Ser Thr His 
    50                  55                  60                  


Ser Thr Leu Thr Thr Glu Pro Ala Ala Lys Thr Thr Thr Ala Arg Thr 
65                  70                  75                  80  


Thr Val Thr Thr Ser Ala Pro Thr Ser Thr Gln Ser Thr Ser Ser Ser 
                85                  90                  95      


Ser Thr Ser Ala Thr Val Thr Thr Leu Ala Pro Thr Thr Thr Gly His 
            100                 105                 110         


Asn Thr Thr Asn Ser Thr Thr Glu Pro Pro Thr Thr Thr Gly His Asn 
        115                 120                 125             


Thr Thr Asn Ser Thr Thr Asp Ala Pro Thr Thr Thr His Thr Asn Ala 
    130                 135                 140                 


Thr Val Ala Pro Thr Pro Pro Pro Thr Thr Pro Ser Val Pro Lys Pro 
145                 150                 155                 160 


Thr Val Gly Asn Tyr Ser Val Lys Thr Asp Asn Val Ser Asp Cys Leu 
                165                 170                 175     


Leu Ala Lys Met Gly Leu Gln Phe Ser Phe Lys Ile Ser Gly Asn Ala 
            180                 185                 190         


Ser Leu Gln Thr Val Asn Leu Asp Pro Asn Val Thr Lys Val Asn Gly 
        195                 200                 205             


Thr Cys Gly Ser Gly Gly Ser Asp Ser Ser Leu Phe Leu Thr Ser Lys 
    210                 215                 220                 


Asp Ile Thr Val His Phe Val Phe Thr Asn Asp Ser Gln Lys Phe Arg 
225                 230                 235                 240 


Leu His Ala Leu Thr Leu Thr Val Asp Leu Gly Asn Gly Asn Ile Phe 
                245                 250                 255     


Asn Asp Ser Asn Thr Asn Leu Ser Leu Trp Glu Ala Ser Val Gly Ser 
            260                 265                 270         


Ser Tyr Met Cys Arg Lys Glu Gln Ser Tyr Asn Ile Ser Asp Lys Leu 
        275                 280                 285             


Thr Leu Asn Thr Phe Glu Leu Gln Val Gln Pro Phe Asp Val Lys Lys 
    290                 295                 300                 


Asn Ser Phe Ser Thr Ala His Glu Cys Ser Leu Asp Asp Thr Ser Leu 
305                 310                 315                 320 


Leu Ile Pro Ile Ile Val Gly Ala Ala Leu Ala Gly Leu Ile Phe Ile 
                325                 330                 335     


Val Val Ile Ala Tyr Val Ile Gly Arg Arg Arg Thr Tyr Val Gly Tyr 
            340                 345                 350         


Gln Thr Leu 
        355 


<210>  28
<211>  411
<212>  PRT
<213>  Papio anubis

<400>  28

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Gln Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Gly Lys Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp Arg Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Ser Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Ile Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Ile Thr Val Asp Glu Leu Leu Ala Ile Lys 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln Asn Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Glu Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys 
        355                 360                 365             


Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val 
    370                 375                 380                 


Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
                405                 410     


<210>  29
<211>  410
<212>  PRT
<213>  Macaca mulatta

<400>  29

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Gln Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Gly Lys Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp Arg Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Ser Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Ile Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Ile Thr Val Asp Glu Leu Leu Ala Ile Lys 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln Asn Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Glu Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Glu Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys Arg His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  30
<211>  364
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  SITE
<222>  (200)..(200)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser His Ala Leu Glu Leu Asn 
            20                  25                  30          


Glu Ala Asp Ser Ala Ile Asn Cys Ser Lys Cys Lys Thr Val Thr Ile 
        35                  40                  45              


Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly Asp Asp 
    50                  55                  60                  


Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe Ser Trp 
65                  70                  75                  80  


Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp Ser Ile 
                85                  90                  95      


Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp Ala Glu 
            100                 105                 110         


Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Lys Ile Pro 
        115                 120                 125             


Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu Lys Asn 
    130                 135                 140                 


Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe Val Gln 
145                 150                 155                 160 


Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp Lys Thr 
                165                 170                 175     


Ser Thr Val Ala Pro Thr Val His Thr Thr Val Pro Ser Pro Thr Thr 
            180                 185                 190         


Thr Pro Thr Arg Ile Pro Pro Xaa Val Ala Ser Val Ile Asn Ile Asn 
        195                 200                 205             


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
    210                 215                 220                 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
225                 230                 235                 240 


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
                245                 250                 255     


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
            260                 265                 270         


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
        275                 280                 285             


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
    290                 295                 300                 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu 
305                 310                 315                 320 


Cys Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly 
                325                 330                 335     


Val Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile 
            340                 345                 350         


Gly Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
        355                 360                 


<210>  31
<211>  411
<212>  PRT
<213>  Canis lupus familiaris

<400>  31

Met Val Cys Phe Arg Leu Ser Pro Ala Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Leu Cys Leu Val Leu Gly Ala Val Ser Ser Tyr Ala Leu Glu Val Asn 
            20                  25                  30          


Val Thr Asp Ser Glu Lys Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Ile Gln Tyr Asn Thr Thr Ser Lys Asn Phe Lys Thr Ala 
    50                  55                  60                  


Thr Ile Ser Asp Phe Ser Thr Ala Thr Tyr Asn Gly Ser Val Cys Gly 
65                  70                  75                  80  


Asn Asp Gln Asn Asn Pro Lys Ile Val Val Gln Phe Gly Ser Gly Phe 
                85                  90                  95      


Ser Trp Ile Val Asn Phe Thr Lys Lys Glu Ser Ala Tyr Leu Ile Asp 
            100                 105                 110         


Ser Ile Ser Phe Ser Tyr Asn Leu Ser Asp Asn Ala Thr Phe Pro Asp 
        115                 120                 125             


Ala Lys Glu Lys Gly Ile Leu Thr Val His Asp Leu Val Gly Phe Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asn Ile Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Gly Val Val Gln Tyr Tyr Trp Asp Val His Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Lys Glu Phe Leu Cys Glu Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Thr Val Val Pro Thr Ile Ser Thr Thr Thr Pro Ser 
        195                 200                 205             


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Val Gly Ser Tyr 
    210                 215                 220                 


Ser Val Asn Asn Ser Asn Gly Thr Cys Leu Leu Ala Thr Met Gly Leu 
225                 230                 235                 240 


Gln Leu Asn Ile Thr His Asn Lys Val Ala Ser Val Ile Asn Ile Asn 
                245                 250                 255     


Pro Asn Thr Thr Asp Phe Thr Gly Ser Cys Gln Pro Gln Thr Ala Leu 
            260                 265                 270         


Leu Arg Leu Asn Ser Ser Asn Ile Lys Tyr Leu Asp Phe Val Phe Ala 
        275                 280                 285             


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Met 
    290                 295                 300                 


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
305                 310                 315                 320 


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
                325                 330                 335     


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
            340                 345                 350         


Val Gln Pro Phe Asn Val Met Glu Gly Lys Tyr Ser Thr Ala Gln Glu 
        355                 360                 365             


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
    370                 375                 380                 


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Leu Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
                405                 410     


<210>  32
<211>  417
<212>  PRT
<213>  Equus caballus

<400>  32

Met Val Cys Phe Arg Leu Ser Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Leu Cys Leu Val Leu Gly Ala Val Ser Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Lys Ala Leu Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Ile Pro Tyr Glu Thr Thr Ser Lys Ser Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asn Phe Gly Thr Pro Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asn Gln Asn Gly Ser Arg Ile Ala Val Gln Phe Gly Ser Gly Phe 
                85                  90                  95      


Ser Trp Ile Val Asn Phe Thr Lys Ser Val Ser Val Tyr Ser Ile Asp 
            100                 105                 110         


Ser Ile Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Lys Asp Lys Gly Ile Leu Thr Val Asn Glu Ser Val Ala Phe Lys 
    130                 135                 140                 


Ile Pro Leu Asn Asp Ile Phe Arg Cys Asn Ser Leu Ser Ser Leu Val 
145                 150                 155                 160 


Lys Asn Gly Val Val Gln Asn Tyr Trp Asp Val His Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Tyr Leu Cys Glu Lys Asp 
            180                 185                 190         


Asn Thr Thr Thr Thr Val Ala Pro Ile Val Pro Thr Thr Val Pro Ser 
        195                 200                 205             


Pro Thr Thr Thr Ser Ser Pro Thr Thr Thr Pro Ser Pro Lys Glu Lys 
    210                 215                 220                 


Pro Asp Val Gly Ser Tyr Leu Val Lys Asn Gly Ser Asp Thr Cys Leu 
225                 230                 235                 240 


Leu Ala Thr Met Gly Leu Gln Leu Asn Val Thr His Asp Lys Val Ala 
                245                 250                 255     


Ser Val Ile Asn Ile Asn Pro Asn Val Thr Gly Tyr Ser Gly Ser Cys 
            260                 265                 270         


His Pro Gln Thr Ala Leu Leu Arg Leu Asn Ser Ser Asn Ile Lys Tyr 
        275                 280                 285             


Leu Asp Phe Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys 
    290                 295                 300                 


Glu Val Asn Val Ser Met Tyr Leu Ala Asn Gly Ser Val Phe Ser Phe 
305                 310                 315                 320 


Ala Asn Asn Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr 
                325                 330                 335     


Met Cys Asn Lys Glu Gln Thr Val Ser Val Ser Gly Glu Phe Gln Ile 
            340                 345                 350         


Asn Thr Phe Asp Leu Arg Val Gln Pro Phe Asn Val Lys Asp Gly Lys 
        355                 360                 365             


Tyr Ser Thr Ala Gln Asp Cys Arg Ala Asp Asp Asp Asn Phe Leu Val 
    370                 375                 380                 


Pro Ile Ala Val Gly Ala Ala Leu Ala Gly Val Leu Ile Leu Val Leu 
385                 390                 395                 400 


Leu Ala Tyr Phe Ile Gly Leu Lys Arg His His Ala Gly Tyr Glu Gln 
                405                 410                 415     


Phe 
    


<210>  33
<211>  407
<212>  PRT
<213>  Bos taurus

<400>  33

Met Val Cys Phe Arg Leu Ala Pro Val Pro Gly Ser Gly Phe Leu Leu 
1               5                   10                  15      


Leu Cys Leu Val Leu Gly Ala Val Ser Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Ser Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Ile Arg Tyr Glu Thr Thr Asp Lys His Asn Lys Thr Val 
    50                  55                  60                  


Pro Ile Ser Asp Leu Gly Ala Ala Thr Tyr Asn Gly Ser Phe Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Ser Gly Phe 
                85                  90                  95      


Ser Trp Ile Val Asn Phe Thr Lys Glu Ala Ala Ser Pro Ser Thr Tyr 
            100                 105                 110         


Leu Val Asp Thr Ile Ser Phe Ser Tyr Asn Thr Asn Asp Asn Lys Thr 
        115                 120                 125             


Phe Pro Asp Ala Lys Glu Lys Glu Val Phe Thr Val Asn Asn Arg Val 
    130                 135                 140                 


Ala Leu Lys Ile Pro Leu Asn Asp Ile Phe Arg Cys Asn Ser Leu Ser 
145                 150                 155                 160 


Thr Leu Glu Asn Arg Asp Val Val Gln His Tyr Trp Asp Val His Val 
                165                 170                 175     


Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Thr Glu Phe Leu Cys 
            180                 185                 190         


Asp Lys Asp Lys Thr Val Thr Thr Ala Val Pro Ile Val Pro Thr Thr 
        195                 200                 205             


Leu Pro Ser Pro Thr Lys Pro Val Val Gly Ser Tyr Ser Val Val Asn 
    210                 215                 220                 


Ser Asn Gly Thr Cys Leu Leu Ala Thr Met Gly Leu Gln Leu Asn Ile 
225                 230                 235                 240 


Thr His Asp Lys Val Ala Ser Val Phe Asn Ile Asn Pro Asn Thr Thr 
                245                 250                 255     


Asn Ala Thr Gly Ser Cys Gln Pro Gln Thr Ala Leu Leu Arg Leu Ser 
            260                 265                 270         


Ser Ser Asn Ile Lys Tyr Leu Asp Phe Val Phe Ala Val Lys Asn Glu 
        275                 280                 285             


Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Met Ile Leu Val Asn 
    290                 295                 300                 


Gly Ser Val Tyr Ser Ile Ser Asn Thr Asn Leu Ser Tyr Trp Asp Ala 
305                 310                 315                 320 


Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr Val Ser Val 
                325                 330                 335     


Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val Gln Pro Phe 
            340                 345                 350         


Ser Val Thr Glu Gly Lys Tyr Ser Thr Ala Gln Glu Cys Ser Leu Asp 
        355                 360                 365             


Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly Leu Ser Gly 
    370                 375                 380                 


Leu Ile Ile Val Ile Val Ile Ala Tyr Leu Ile Gly Arg Arg Lys Ser 
385                 390                 395                 400 


Tyr Ala Gly Tyr Gln Thr Leu 
                405         


<210>  34
<211>  411
<212>  PRT
<213>  Sus scrofa

<400>  34

Met Val Cys Phe Arg Leu Ser Pro Val Pro Gly Ser Gly Leu Leu Met 
1               5                   10                  15      


Leu Cys Leu Val Leu Gly Ala Val Ser Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asn Ser Glu Lys Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Ile Arg Tyr Glu Thr Thr Asn Asn Ser His Lys Thr Val 
    50                  55                  60                  


Ser Ile Ser Asp Phe Gly Ala Ala Thr Tyr Asn Gly Ser Phe Cys Gly 
65                  70                  75                  80  


Asp Asp His Asn Asp Pro Gln Ile Val Met Gln Phe Gly Ser Gly Phe 
                85                  90                  95      


Ser Trp Ile Val Asn Phe Ala Lys Glu Ser Ser Ser Tyr Leu Ile Asn 
            100                 105                 110         


Ser Ile Ser Phe Ser Tyr Asn Thr Ser Asp Thr Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Lys Lys Lys Gly Val Leu Thr Val Asn Asp Ser Val Gly Phe Gln 
    130                 135                 140                 


Val Pro Leu Asn Asp Ile Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asp Asn Val Val Gln His Tyr Trp Asp Val His Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Lys Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Leu Thr Thr Thr Val Pro Val Ile Pro Thr Ser Val Pro Ser 
        195                 200                 205             


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Thr Gly Ser Tyr 
    210                 215                 220                 


Ser Val Thr Ser Ser Asn Gly Thr Cys Leu Leu Ala Asn Met Gly Leu 
225                 230                 235                 240 


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
                245                 250                 255     


Pro Asn Thr Thr Asn Ala Thr Gly Asn Cys His Ser Lys Thr Ala Leu 
            260                 265                 270         


Leu Arg Leu Ser Gly Ser Asn Ile Lys Tyr Leu Asp Phe Val Phe Ala 
        275                 280                 285             


Val Lys Asn Asp Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Val 
    290                 295                 300                 


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
305                 310                 315                 320 


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
                325                 330                 335     


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asn Leu Arg 
            340                 345                 350         


Val Gln Pro Phe Ser Val Met Glu Gly Lys Tyr Ser Thr Ala Gln Asp 
        355                 360                 365             


Cys Ser Ala Asp Asp Asp Asn Phe Ile Val Pro Ile Ala Val Gly Ala 
    370                 375                 380                 


Ala Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly 
385                 390                 395                 400 


Leu Lys Arg His His Ala Gly Tyr Glu Gln Phe 
                405                 410     


<210>  35
<211>  408
<212>  PRT
<213>  Ovis aries

<400>  35

Met Val Cys Phe Arg Leu Ala Pro Val Pro Gly Cys Gly Phe Leu Leu 
1               5                   10                  15      


Phe Cys Leu Val Leu Gly Thr Val Ser Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Ser Lys Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Ile Arg Tyr Glu Thr Thr Asp Lys His Asn Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp Phe Asp Ala Ala Ala Tyr Asn Gly Ser Val Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Ser Gly Phe 
                85                  90                  95      


Ser Trp Ile Val Asn Phe Thr Lys Glu Ala Ser Ser Thr Ser Thr Tyr 
            100                 105                 110         


Leu Val Asp Ser Ile Ser Phe Ser Tyr Asn Thr Asn Asp Asn Ala Thr 
        115                 120                 125             


Phe Pro Asp Ala Lys Glu Lys Gly Val Phe Thr Val Asn Asn Arg Val 
    130                 135                 140                 


Ala Leu Lys Ile Pro Leu Asn Asp Ile Phe Arg Cys Asn Ser Leu Ser 
145                 150                 155                 160 


Thr Leu Glu Lys Ser Asp Val Val Gln His Tyr Trp Asp Val His Val 
                165                 170                 175     


Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Thr Glu Phe Leu Cys 
            180                 185                 190         


Asp Lys Asp Lys Thr Val Thr Thr Ala Met Pro Ile Val Pro Thr Thr 
        195                 200                 205             


Ala Pro Ser Pro Thr Lys Pro Val Val Gly Ser Tyr Ser Val Val Asn 
    210                 215                 220                 


Ser Asn Gly Thr Cys Leu Leu Ala Thr Met Gly Leu Gln Leu Asn Ile 
225                 230                 235                 240 


Thr His Asp Lys Val Ala Ser Val Phe Asn Ile Asn Pro Asn Thr Thr 
                245                 250                 255     


Asn Ala Thr Gly Ser Cys Gln Pro Gln Thr Ala Leu Leu Arg Leu Ser 
            260                 265                 270         


Ser Ser Asn Ile Lys Tyr Leu Asp Phe Val Phe Ala Val Lys Asn Glu 
        275                 280                 285             


Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Met Ile Leu Val Asn 
    290                 295                 300                 


Gly Ser Val Tyr Ser Ile Ser Asn Thr Asn Leu Ser Tyr Trp Asp Ala 
305                 310                 315                 320 


Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr Val Ser Val 
                325                 330                 335     


Ser Gly Ala Leu Gln Ile Asn Thr Phe Asp Leu Arg Val Gln Pro Phe 
            340                 345                 350         


Ser Val Thr Glu Gly Lys Tyr Ser Thr Ala Glu Glu Cys Ser Ala Asp 
        355                 360                 365             


Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val Ala Leu Gly 
    370                 375                 380                 


Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly Arg Arg Lys 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Gln Ser Val 
                405             


<210>  36
<211>  411
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Met Arg Leu Leu Ser Pro Val Thr Gly Ser Lys Leu Val Leu Leu Phe 
1               5                   10                  15      


Leu Phe Leu Gly Ala Val Arg Ser Asp Ala Leu Lys Leu Asn Leu Thr 
            20                  25                  30          


Asp Ser Lys Gly Thr Cys Leu Tyr Ala Glu Trp Glu Met Asn Phe Thr 
        35                  40                  45              


Ile Thr Tyr Glu Ala Leu Lys Val Asn Glu Thr Val Thr Ile Thr Val 
    50                  55                  60                  


Pro Asp Lys Val Thr Tyr Asn Gly Ser Ser Cys Gly Asp Asp Lys Asn 
65                  70                  75                  80  


Gly Ala Lys Ile Met Ile Gln Tyr Gly Ser Thr Leu Ser Trp Ala Val 
                85                  90                  95      


Asn Phe Thr Lys Glu Ala Ser Gln Tyr Phe Ile Asn Asn Ile Thr Leu 
            100                 105                 110         


Ser Tyr Asn Thr Asn Asp Thr Lys Thr Phe Pro Gly Ala Val Pro Lys 
        115                 120                 125             


Gly Ile Leu Thr Val Ile Ile Pro Val Gly Ser Gln Leu Pro Leu Gly 
    130                 135                 140                 


Val Ile Phe Lys Cys Ser Ser Val Leu Thr Phe Asn Leu Ser Pro Val 
145                 150                 155                 160 


Val Gln His Tyr Trp Gly Ile His Leu Gln Ala Phe Val Gln Asn Gly 
                165                 170                 175     


Thr Val Ser Lys His Glu Gln Val Cys Lys Glu Asp Lys Thr Ala Thr 
            180                 185                 190         


Thr Val Ala Pro Ile Ile His Thr Thr Val Pro Ser Pro Thr Thr Thr 
        195                 200                 205             


Leu Thr Pro Thr Ser Ile Pro Val Pro Thr Pro Thr Val Gly Asn Tyr 
    210                 215                 220                 


Thr Ile Ser Asn Gly Asn Ala Thr Cys Leu Leu Ala Thr Met Gly Leu 
225                 230                 235                 240 


Gln Leu Asn Ile Thr Glu Glu Lys Val Pro Phe Ile Phe Asn Ile Asn 
                245                 250                 255     


Pro Ala Thr Thr Asn Phe Thr Gly Ser Cys Gln Pro Gln Thr Ala Gln 
            260                 265                 270         


Leu Arg Leu Asn Asn Ser Gln Ile Lys Tyr Leu Asp Phe Ile Phe Ala 
        275                 280                 285             


Val Lys Asn Glu Lys Arg Phe Tyr Leu Lys Glu Val Asn Val Asn Met 
    290                 295                 300                 


Tyr Leu Ala Asn Gly Ser Ala Phe His Val Ser Asn Asn Asn Leu Ser 
305                 310                 315                 320 


Phe Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
                325                 330                 335     


Val Val Ser Val Ser Arg Thr Phe Gln Ile Asn Thr Phe Asn Leu Lys 
            340                 345                 350         


Val Gln Pro Phe Asn Val Thr Lys Gly Glu Tyr Ser Thr Ala Gln Asp 
        355                 360                 365             


Cys Ser Ala Asp Glu Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala 
    370                 375                 380                 


Ala Leu Gly Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly 
385                 390                 395                 400 


Leu Lys Arg His His Thr Gly Tyr Glu Gln Phe 
                405                 410     


<210>  37
<211>  570
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  37

Met Ala Met Lys Asn Phe Thr Leu Gln Gln Glu Arg Asp Thr Ser Val 
1               5                   10                  15      


Ala Leu Ile Ile Arg Thr Tyr Val Arg Ala Phe Leu Lys Val Tyr Thr 
            20                  25                  30          


Lys Val Pro Lys Pro Gln Arg Cys His Asn Gln Trp Gln Ser Leu Asn 
        35                  40                  45              


Ile Glu Gly Ile Glu Gly Ile Glu Ile Val Lys Gly Ser Lys Trp Arg 
    50                  55                  60                  


Ser Ala Leu Glu Thr Ile Ile Thr Ile Gln Val Lys Arg Lys Ser Gln 
65                  70                  75                  80  


Val Gln Lys Tyr His Pro Phe Ser Leu His Ser Glu Cys Gln Lys Thr 
                85                  90                  95      


Asn Gln Glu Gly Thr Gly Gly Val Ala Thr Val Ile Ala Asp Glu Cys 
            100                 105                 110         


Leu Leu Trp Pro Ser Ile Pro Phe Ser Thr Leu Ala Gln Lys Val Asn 
        115                 120                 125             


Leu Gly Ser Cys Glu Ala Phe Ser Ile Ile Gly Tyr Ser Val Phe Ala 
    130                 135                 140                 


Leu Phe Ile Tyr Leu Lys Pro Asn Met Leu Asp Phe Ile Glu Leu Ala 
145                 150                 155                 160 


Glu Leu Met Leu Ser Thr Glu Thr Gln Leu Leu Glu Pro Thr Arg Val 
                165                 170                 175     


Cys Cys Gly Ile Cys Gln Ser Tyr Ala Leu Glu Ile Asn Leu Thr Asp 
            180                 185                 190         


Ser Lys Asn Ala Thr Cys Leu Tyr Ser Lys Trp Gln Met Thr Phe Thr 
        195                 200                 205             


Ile Asn Tyr Glu Thr Thr Gly Asn Glu Thr Lys Asn Val Thr Val Thr 
    210                 215                 220                 


Val Pro Glu Asn Val Thr Tyr Asp Gly Ser Ser Cys Gly Asp Asn Gln 
225                 230                 235                 240 


Thr Val Pro Gln Ile Ala Val Gln Phe Gly Leu Gly Tyr Ser Trp His 
                245                 250                 255     


Leu Asn Phe Thr Lys Lys Glu Asn Asn Ser Tyr Ser Phe Asp Thr Ile 
            260                 265                 270         


Val Phe Thr Tyr Asn Thr Ser Asp Asn Glu Thr Phe Pro Glu Ala Lys 
        275                 280                 285             


Glu Lys Gly Gln Val Leu Ser Val Phe Glu Phe Arg Tyr Ala Arg Ile 
    290                 295                 300                 


Pro Leu Asn Lys Ile Phe Arg Cys His Ser Glu Glu Ser Leu Ile Gly 
305                 310                 315                 320 


Asp Lys Ala Thr His His Tyr Trp Glu Thr Val Val Gln Ala Phe Ile 
                325                 330                 335     


Gln Asn Gly Thr Ile Ser Lys Glu Glu Phe Ile Cys Ser Lys Asp Arg 
            340                 345                 350         


Ala Ser Thr Thr Val Ala Pro Val Thr Thr Gln Val Val Pro Ser Thr 
        355                 360                 365             


Thr Ala Thr Pro Val Pro Gln Asp Lys Pro Tyr Pro Gly Lys Tyr Ala 
    370                 375                 380                 


Val Lys Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
385                 390                 395                 400 


Leu Asn Val Thr Gln Asn Lys Val Asn Ser Val Ile Asn Ile Asn Pro 
                405                 410                 415     


Asn Val Thr Asp Phe Thr Gly Ser Cys Ser Asn Glu Thr Ala Glu Leu 
            420                 425                 430         


Arg Leu Ser Gly Ser Asn Val Lys Tyr Ile Asp Phe Ile Phe Ala Val 
        435                 440                 445             


Lys Asn Gly Asn Arg Phe Tyr Leu Lys Glu Val Asn Val Ser Ile Ser 
    450                 455                 460                 


Phe Val Asn Ala Ser Asp Leu Asn Val Ala Asn Asn Asn Leu Ser Tyr 
465                 470                 475                 480 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                485                 490                 495     


Leu Ala Leu Ala Asp Ser Leu Gln Ile Asn Thr Phe Asn Leu Arg Val 
            500                 505                 510         


Gln Pro Phe Ser Val Val Ala Gly Lys Tyr Ser Thr Ala Glu Asp Cys 
        515                 520                 525             


Ser Ala Asp Asp Asp Asn Phe Ile Val Pro Ile Ala Val Gly Ala Ala 
    530                 535                 540                 


Leu Gly Gly Leu Val Ile Leu Val Leu Met Ala Tyr Phe Val Gly Arg 
545                 550                 555                 560 


Lys Arg Arg Ala Thr Gly Tyr Glu Gln Phe 
                565                 570 


<210>  38
<211>  425
<212>  PRT
<213>  Gallus gallus

<400>  38

Met Ala Pro Pro Arg Cys Pro Ala Gly Leu Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Ala Cys Gly Phe Phe Gln Ser Tyr Ala Val Glu Val Asp Val 
            20                  25                  30          


Lys Asp Ala Ser Asn Phe Thr Cys Leu Tyr Ala Gln Trp Met Met Lys 
        35                  40                  45              


Phe Leu Ile Lys Tyr Glu Thr Asn Ser Ser Asp Tyr Lys Asn Ala Ser 
    50                  55                  60                  


Leu Asp Leu Thr Ser Thr Val Thr His Asn Gly Ser Ile Cys Gly Ser 
65                  70                  75                  80  


Asp Thr Gln Ala Ala Leu Leu Ala Val Gln Phe Gly Asp Gly His Ser 
                85                  90                  95      


Trp Ser Ile Asn Phe Thr Lys Asn Asn Glu Thr Tyr Arg Ala Glu Phe 
            100                 105                 110         


Ile Thr Phe Thr Tyr Asn Thr Asn Asp Thr Ala Val Phe Pro Asp Ala 
        115                 120                 125             


Arg Arg Gln Gly Pro Val Thr Ile Val Val Lys Asp Ala Met His Pro 
    130                 135                 140                 


Ile Gln Leu Asn Asn Val Phe Val Cys His His Thr Thr Ser Leu Glu 
145                 150                 155                 160 


Ala Glu Asn Val Thr Gln Ile Phe Trp Asn Val Thr Met Gln Pro Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Ile Ser Lys Lys Glu Ser Arg Cys Tyr Ala Asp 
            180                 185                 190         


Thr Pro Thr Ala Ala Pro Thr Val Leu Pro Thr Val Ala Asn Val Thr 
        195                 200                 205             


Thr Ala Ser Thr Thr Ile Ser Pro Ala Pro Thr Thr Ala Pro Lys Pro 
    210                 215                 220                 


Ala Glu Asn Pro Val Thr Gly Asn Tyr Ser Leu Lys Thr Gly Asn Lys 
225                 230                 235                 240 


Thr Cys Leu Leu Ala Thr Val Gly Leu Gln Leu Asn Ile Ser Gln Asp 
                245                 250                 255     


Lys Pro Leu Leu Ile Asn Ile Asp Pro Lys Thr Thr His Ala Asp Gly 
            260                 265                 270         


Thr Cys Gly Asn Thr Ser Ala Thr Leu Lys Leu Asn Asp Gly Asn Arg 
        275                 280                 285             


Thr Leu Ile Asp Phe Thr Phe Ile Val Asn Ala Ser Ala Ser Val Gln 
    290                 295                 300                 


Lys Phe Tyr Leu Arg Glu Val Asn Val Thr Leu Leu Asn Tyr Gln Asn 
305                 310                 315                 320 


Gly Ser Val Ile Leu Ser Ala Asp Asn Asn Asn Leu Ser Lys Trp Asp 
                325                 330                 335     


Ala Ser Leu Gly Asn Ser Tyr Met Cys Arg Lys Glu Gln Thr Leu Glu 
            340                 345                 350         


Ile Asn Glu Asn Leu Gln Val His Thr Phe Asn Leu Trp Val Gln Pro 
        355                 360                 365             


Phe Leu Val Lys Glu Asn Lys Phe Ser Ile Ala Glu Glu Cys Phe Ala 
    370                 375                 380                 


Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Met Ala Leu 
385                 390                 395                 400 


Gly Phe Leu Ile Ile Leu Val Phe Ile Ser Tyr Ile Ile Gly Arg Arg 
                405                 410                 415     


Lys Ser Arg Thr Gly Tyr Gln Ser Val 
            420                 425 


<210>  39
<211>  556
<212>  PRT
<213>  Taeniopygia guttata

<400>  39

Met Glu Cys Arg Glu Gly Glu Val Thr Arg Cys Lys Gln Lys Asn Asn 
1               5                   10                  15      


Leu Phe Ser Gly Ile Asn Asp Asp Ile Ser Gly Ala Lys Gln Ala Lys 
            20                  25                  30          


Gln Arg Gln Cys Thr Pro Gln Lys Pro Pro Lys Arg Ala Thr Ala Thr 
        35                  40                  45              


Leu Pro Leu Gln Arg Pro Pro Arg Gly Ile Pro Gly Pro Ala Pro Ala 
    50                  55                  60                  


Ala Val Ala Ala Ala Val Ala Ala Asp Arg Ile Thr Pro Ser Gly Ser 
65                  70                  75                  80  


His Gln Thr Arg Pro Pro Glu Ala Ala Arg Asp Glu Arg Pro Val Arg 
                85                  90                  95      


Asp Pro Arg Asn Arg Ala Ala Ala Pro Ser Gly His Trp Arg Arg Ala 
            100                 105                 110         


Gly Gly Pro Gln Arg His Arg His His Arg His Arg Arg His Gly Pro 
        115                 120                 125             


Ala Pro Leu Arg Arg Leu Leu Leu Arg Pro Pro Pro Pro Ala Ala Ala 
    130                 135                 140                 


Ala Ala Arg Phe Leu Gly Phe Phe Gln Ser Tyr Ala Val Glu Val Asp 
145                 150                 155                 160 


Ile Lys Asp Ala Ser Asn Ala Thr Cys Leu Tyr Ala Asp Trp Met Met 
                165                 170                 175     


Arg Phe Leu Ile Lys Tyr Glu Ser Asn Ser Gly Asp Tyr Lys Thr Thr 
            180                 185                 190         


Thr Leu Asn Leu Ser Ser Ser Val Thr His Asn Gly Ser Val Cys Gly 
        195                 200                 205             


Asn Asp Thr Gln Ala Ala Leu Val Ala Val Gln Phe Gly Glu Gly His 
    210                 215                 220                 


Ser Trp Ser Ile Asn Ile Thr Lys Asn Asn Glu Thr Tyr Gln Gly Asp 
225                 230                 235                 240 


Phe Ile Thr Leu Thr Tyr Asn Thr Asn Asp Thr Ala Val Phe Pro Asp 
                245                 250                 255     


Ala Lys Arg Lys Gly Pro Ile Thr Val Leu Val Arg Asp Pro Ser Arg 
            260                 265                 270         


Pro Ile Gln Leu Asn Thr Val Phe Val Cys His Asn Ser Phe Val Ile 
        275                 280                 285             


Glu Ala Glu Asn Thr Thr Gln Ile Phe Trp Asn Val Thr Met Gln Ala 
    290                 295                 300                 


Phe Val Gln Asn Gly Thr Val Ser Lys Lys Glu Ser Arg Cys Pro Ala 
305                 310                 315                 320 


Asp Thr Pro Thr Ser Glu Pro Thr Val Pro Pro Thr Ile Ala Asn Val 
                325                 330                 335     


Thr Thr Ala Ser Thr Thr Thr Leu Ser Pro Ala Pro Thr Thr Ala Pro 
            340                 345                 350         


Lys Pro Val Glu Asn Pro Val Thr Gly Asn Tyr Ser Leu Lys Ser Gly 
        355                 360                 365             


Asn Lys Thr Cys Phe Leu Ala Thr Val Gly Leu Gln Leu Asn Val Ser 
    370                 375                 380                 


Gln Glu Lys Pro Leu Leu Ile Asn Ile Asn Pro Lys Thr Thr Val Ala 
385                 390                 395                 400 


Asp Gly Ala Cys Gly Asn Thr Thr Ala Thr Leu Lys Leu Asn Asp Gly 
                405                 410                 415     


Asn Ser Thr Leu Ile Gly Phe Thr Phe Ala Val Lys Asn Thr Ser Ala 
            420                 425                 430         


Ser Val Gln Lys Phe Tyr Leu Arg Glu Val Asn Val Thr Leu Leu Asn 
        435                 440                 445             


Arg Leu Asn Gly Ser Val Ile Ser Ser Ala Asp Asn Ser Asn Leu Ser 
    450                 455                 460                 


Lys Trp Asp Ala Phe Leu Gly Ser Ser Tyr Met Cys Arg Lys Glu Gln 
465                 470                 475                 480 


Thr Leu Gln Ile Asn Glu Asn Val Gln Val His Thr Phe Asn Leu Trp 
                485                 490                 495     


Ile Gln Pro Phe Leu Val Glu Ala Asn Lys Phe Ala Thr Ala Glu Glu 
            500                 505                 510         


Cys Ile Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Ile Ala Val Gly 
        515                 520                 525             


Val Ala Leu Gly Phe Leu Ile Ile Leu Val Phe Ile Ser Tyr Ile Ile 
    530                 535                 540                 


Gly Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
545                 550                 555     


<210>  40
<211>  408
<212>  PRT
<213>  Xenopus tropicalis

<400>  40

Met Glu Arg Cys Ala Cys Pro Ala Ala Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Leu Met Gly Ala Met Ala Phe Asp Val Glu Ile Lys Asp Asp Lys Asn 
            20                  25                  30          


Ala Thr Cys Ile Tyr Ala Lys Leu Ser Val Asn Val Thr Val Gln Tyr 
        35                  40                  45              


Glu Thr Asn Thr Ser Ser Thr Lys Asn Val Thr Phe Ser Val Pro Ser 
    50                  55                  60                  


Glu Val Thr Thr Asn Gly Ser Ser Cys Gly Ser Asn Gly Lys Ala Pro 
65                  70                  75                  80  


Ile Leu Val Ile Asn Phe Gly Asn Gly His Ser Trp Ser Leu Asn Phe 
                85                  90                  95      


Thr Arg Asn Asp Ser Met Tyr Ser Gly Gly Ala Leu Ile Phe Thr Tyr 
            100                 105                 110         


Asn Thr Asn Asp Ser Thr Leu Phe Pro Asp Ala Leu Lys Glu Gly Leu 
        115                 120                 125             


Ile Ser Ser Thr Ala Ala Phe Leu Gly Pro Ile Pro Leu Asn Ser Thr 
    130                 135                 140                 


Tyr Lys Cys Ile Ser Ser Glu Val Val Val Ser Glu Asn Val Thr Gln 
145                 150                 155                 160 


Ile Ile Ser Asp Val Lys Leu Glu Ala Phe Met Gln Asn Gly Thr Leu 
                165                 170                 175     


Gly Lys Glu Val Ser Cys Asp Ala Asp Lys Pro Ser Pro Thr Pro Thr 
            180                 185                 190         


Thr Asn Pro Ser Thr Thr Ala Ser Thr Thr Thr Pro Thr Pro Thr Ser 
        195                 200                 205             


Lys Pro Leu Asp Asn Pro Thr Thr Gly Asn Tyr Ser Val Ser Asp Val 
    210                 215                 220                 


Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Ile Asn Thr Ser 
225                 230                 235                 240 


Leu Leu Ser Glu Gly Lys Asn Ile Trp Thr Ala Phe Asn Ile Asp Pro 
                245                 250                 255     


Thr Ala Met Ser Lys Asn Gly Thr Cys Ser Asn Gln Thr Gly Thr Leu 
            260                 265                 270         


Ile Leu Thr Asp Asn Ser Thr Val Ile Glu Phe Thr Leu Ala Leu Lys 
        275                 280                 285             


Asn Lys Asn His Phe Tyr Leu Lys Glu Val Asn Val Ala Leu Ile Asn 
    290                 295                 300                 


Gly Ser Ala Ser Ser Thr Arg Gln Asn Gln Asn Leu Ser Ala Trp Glu 
305                 310                 315                 320 


Ala Ser Val Gly Ser Ser Tyr Met Cys His Lys Glu Gln Gln Ile Lys 
                325                 330                 335     


Val Ser Glu Asp Leu Val Ile Asn Ser Phe Asp Val Arg Val Gln Leu 
            340                 345                 350         


Phe Gly Val Lys Asn Glu Thr Phe Ala Thr Ala Gln Gln Cys Ser Leu 
        355                 360                 365             


Asp Asp Asp Ser Ile Val Ile Pro Ile Val Val Gly Ala Ala Leu Ala 
    370                 375                 380                 


Gly Leu Ile Val Ile Ile Val Ile Ala Tyr Leu Ile Gly Arg Arg Lys 
385                 390                 395                 400 


Gly Tyr Ser Gly Tyr Gln Thr Leu 
                405             


<210>  41
<211>  404
<212>  PRT
<213>  Salmo salar

<400>  41

Met Phe Arg Cys Ala Phe Leu Ile Leu Phe Leu Ala Leu Gly Asn Glu 
1               5                   10                  15      


Leu His Leu Ser His Gly Thr Glu Val Ser Val Asn Asn Thr Glu Asn 
            20                  25                  30          


Lys Leu Cys Leu Tyr Ala Asn Leu Met Val Asn Phe Ser Val Thr Tyr 
        35                  40                  45              


Glu Val Gly Val Asn Lys Asn Glu Thr Val Ile Phe Val Leu Pro Glu 
    50                  55                  60                  


Asn Val Thr Thr Glu Gly Ser Thr Cys Asp Asn Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Lys Leu Ser Phe Gly His Gly His Ser Trp Thr Val Glu Phe Thr Lys 
                85                  90                  95      


Lys Asn Lys Thr Tyr Gln Val Asp Thr Ile Val Phe Ser Tyr Asn Leu 
            100                 105                 110         


Asn Asp Ser Ser Val Phe Pro Asn Ser Thr Ser Lys Glu Thr Lys Phe 
        115                 120                 125             


Val Thr Val Lys Ser Ile Ile Thr Asn Val Ser Val Asp Thr Tyr Tyr 
    130                 135                 140                 


Ser Cys Lys Ser Glu Asn Val Leu Thr Val Glu Ser Val Ile Gln Thr 
145                 150                 155                 160 


Leu Tyr Asp Val Ala Leu Gln Ala Phe Val Ile Asn Gly Ser Lys Ser 
                165                 170                 175     


Asp Thr Asp Thr Val Cys Ser Ala Asp Met Thr Ser Thr Thr Val Ala 
            180                 185                 190         


Pro Thr Thr Thr Val Thr Ser Thr Ala Ala Pro Thr Ser Thr Pro Thr 
        195                 200                 205             


Leu Pro Thr Pro Thr Thr Gly Lys Tyr Ser Ile Ala Pro Asp Val Asn 
    210                 215                 220                 


Ser Thr Ala Cys Leu Met Ala Thr Phe Gly Leu Gln Ile Gly Tyr Lys 
225                 230                 235                 240 


Gln Gly Asp Lys Glu Glu Thr Ile Asn Leu Val Pro Asn Ile Thr Glu 
                245                 250                 255     


Val Gly Gly Ala Cys Gly Ala Asn Ser Ser Asp Leu Ile Leu Thr Ser 
            260                 265                 270         


Asp Thr Ile Thr Ile Met Phe Thr Phe Ser Asn Asp Gly Lys Lys Phe 
        275                 280                 285             


His Leu His Ala Leu Lys Val Thr Val Lys Pro Ala Thr Gly Asp Pro 
    290                 295                 300                 


Val Ile Ala Val Asn Asn Asn Met Ser Ile Trp Ala Ala Ala Val Gly 
305                 310                 315                 320 


Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr Leu Asn Val Thr Asp Thr 
                325                 330                 335     


Leu Thr Leu Tyr Thr Phe Glu Leu Arg Val Gln Pro Phe Glu Val Asn 
            340                 345                 350         


Lys Gly Glu Phe Ala Thr Ala His Glu Cys Ser Leu Asp Asp Thr Ser 
        355                 360                 365             


Ile Leu Ile Pro Ile Ile Val Gly Ala Ala Leu Ala Gly Leu Ile Leu 
    370                 375                 380                 


Ile Val Val Ile Ala Tyr Val Ile Gly Arg Arg Lys Thr Tyr Val Gly 
385                 390                 395                 400 


Tyr Gln Thr Leu 
                


<210>  42
<211>  410
<212>  PRT
<213>  Oreochromis niloticus

<400>  42

Met Lys Val Ser His Ala Thr Ala Gly Leu Val Val Trp Phe Val Val 
1               5                   10                  15      


Leu Gly Cys Ile Asp Ala Val Thr Leu Glu Val Lys Glu Ser Asn Thr 
            20                  25                  30          


Thr Cys Ile Lys Ala Asp Leu Ser Ala Ser Phe Ser Ile Ile Tyr Asn 
        35                  40                  45              


Thr Thr His Ala Glu Arg Thr Val Gln Val Leu Leu Pro Asn Ser Thr 
    50                  55                  60                  


Thr Val Asp Thr Ala Asn Ser Thr Cys Gly Lys Asp Gly Ser Ser Pro 
65                  70                  75                  80  


Arg Leu Val Ala Val Phe Gly Ser Gly Tyr Thr Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Thr Asn Gly Thr Leu Tyr Gln Val Ser Ser Leu Thr Leu Gln Tyr 
            100                 105                 110         


Asn Leu Ser Asp Thr Ser Val Phe Pro Asn Ala Thr Ile Ser Gly Val 
        115                 120                 125             


Val Thr Leu Val Ser Ala Ser Val Gly Ile Glu Ala Asn Val Asn Thr 
    130                 135                 140                 


Thr Tyr Lys Cys Ala Ser Pro Thr Val Ile Asp Val Ala Thr Ala Lys 
145                 150                 155                 160 


Val Asn Phe Thr Asp Met Arg Leu Glu Ala Tyr Met Pro Gly Asn Glu 
                165                 170                 175     


Leu Ser Pro Asn Glu Thr Val Cys Phe Ala Asp Gln Thr Ser Thr Thr 
            180                 185                 190         


Pro Ser Pro Thr Thr Val Ser Thr Thr Ala Val Pro Thr Gln Thr Pro 
        195                 200                 205             


Pro Gly Thr Pro Gln Gln Gly Asn Tyr Thr Val Lys Asp Ala Asn Asp 
    210                 215                 220                 


Thr Ile Cys Leu Leu Ala Lys Met Gly Leu Gln Leu Asn Val Ser Tyr 
225                 230                 235                 240 


Thr Ser Gln Asn Lys Thr Val Gln Asp Val Leu Asn Leu Asn Pro Asn 
                245                 250                 255     


Val Thr Asn Ser Thr Gly Ser Cys Gly Ala Ser Ser Ala Thr Leu Val 
            260                 265                 270         


Leu Thr Gln Thr Gln Ser Thr Ile Leu Thr Phe Asn Phe Thr Leu Asn 
        275                 280                 285             


Ser Thr Thr Asn Lys Tyr His Leu Ser Gly Val Thr Leu Ile Ala Asn 
    290                 295                 300                 


Trp Phe Asp Ser Ala His Phe Ser Met Ser Asn Asn Ser Leu Asn Tyr 
305                 310                 315                 320 


Leu Arg Ser Thr Leu Gly Tyr Ser Tyr Met Cys Asn Ala Glu Gln Thr 
                325                 330                 335     


Leu Phe Val Thr Pro Ser Phe Ser Leu Asn Thr Phe Asp Leu Gln Val 
            340                 345                 350         


Gln Pro Phe Gly Val Lys Ser Gly Arg Phe Ala Thr Ala Glu Glu Cys 
        355                 360                 365             


Gln Met Asp Gln Asn Gln Met Ile Ile Pro Ile Ile Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Leu Val Leu Ile Thr Leu Ile Ala Tyr Leu Ile Gly Lys 
385                 390                 395                 400 


Arg Arg Ser His Ala Gly Tyr Gln Ala Ile 
                405                 410 


<210>  43
<211>  249
<212>  PRT
<213>  Takifugu rubripes

<400>  43

Met Thr Gln Ile Gly Gly Val Gln Pro Val Phe Leu Ala Val Thr Val 
1               5                   10                  15      


His Leu Ile Leu Ala Thr Val Leu His Gln Thr Phe Ala Thr Val Thr 
            20                  25                  30          


Pro Pro Val Thr Thr Ala Val Pro His Lys Glu Pro Gly Arg Pro Asp 
        35                  40                  45              


Gln Gly Asp Tyr Gln Val Thr Ser Ser Asn Gly Thr Val Cys Phe Leu 
    50                  55                  60                  


Ala Ser Met Gly Leu Gln Leu Asn Ile Thr Phe Asn Ser Thr Ser Gln 
65                  70                  75                  80  


Asn Lys Thr Leu Gln Glu Val Ile Asn Ile Gln Pro Asn Arg Thr Lys 
                85                  90                  95      


Ser Ser Gly Ser Cys Asp Thr Ser Ser Ala Leu Leu Thr Leu Thr Thr 
            100                 105                 110         


Asp Ala Glu Lys Thr Asn Leu Thr Phe Val Phe Ala Leu Asn Thr Thr 
        115                 120                 125             


Ser Asn Lys Tyr His Leu Ser Glu Val Ser Leu Ser Ala Ala Leu Ser 
    130                 135                 140                 


Asp Met Lys Glu Thr Phe Val Ala Gln Asn His Ser Leu Asp Tyr Leu 
145                 150                 155                 160 


Arg Gly Thr Leu Gly Phe Ser Tyr Met Cys Arg Glu Arg Gln Thr Leu 
                165                 170                 175     


Gly Val Thr Pro Asp Phe Ala Ile Asn Thr Phe Gln Val Gln Val Gln 
            180                 185                 190         


Pro Phe Gly Val Thr Gly Lys Gln Phe Ala Ala Ala Glu Glu Cys Gln 
        195                 200                 205             


Leu Asp Lys Asp Asp Met Leu Ile Pro Ile Ile Val Gly Ala Ala Leu 
    210                 215                 220                 


Ala Ala Leu Val Leu Ile Val Leu Ser Ala Tyr Leu Ile Gly Arg Lys 
225                 230                 235                 240 


Arg Ser His Ala Gly Tyr Gln Ser Ile 
                245                 


<210>  44
<211>  418
<212>  PRT
<213>  Pan troglodytes

<400>  44

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Ser Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Thr Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Val Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Ser Trp 
                245                 250                 255     


Gly His Arg Thr Ile Thr Leu Ser Ser Lys Ser Leu Ser Gly Gly Cys 
            260                 265                 270         


Leu Ala Arg Asn Glu His Ser Pro His Pro Leu Phe Leu Phe Phe Glu 
        275                 280                 285             


Lys Gly Pro Pro Ser Val Thr Gln Ala Glu Asp Glu Glu Ser Tyr Tyr 
    290                 295                 300                 


Ile Ser Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile 
305                 310                 315                 320 


Tyr Gln Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly 
                325                 330                 335     


His Ser Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His 
            340                 345                 350         


Leu Gln Leu Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu 
        355                 360                 365             


Asp Asp His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile 
    370                 375                 380                 


Val Leu Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly 
385                 390                 395                 400 


Met Gly Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln 
                405                 410                 415     


Arg Ile 
        


<210>  45
<211>  416
<212>  PRT
<213>  Papio anubis

<400>  45

Met Pro Arg Gln Leu Ser Ala Ala Ala Val Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Lys 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Gly Gln Asp Ile 
        35                  40                  45              


Ala Lys Pro Val Gln Gln Pro Ala Asn Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Leu Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Ile Lys Thr Pro Thr Thr Thr Pro Val Thr Thr Lys Asn Thr Pro Thr 
                85                  90                  95      


Thr Ser Pro Ile Ile Tyr Thr Leu Val Thr Thr Gln Ala Thr Ser Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Leu Thr Lys Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Asn His Thr Thr Gly Asn Ala Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Ser Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Leu Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Asn Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Gly Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Cys Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Met Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Leu Lys Thr Thr Asn Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Val Gly Ile Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  46
<211>  416
<212>  PRT
<213>  Macaca mulatta

<400>  46

Met Pro Arg Gln Leu Ser Ala Ala Ala Val Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Lys 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Gly Gln Asp Ile 
        35                  40                  45              


Ala Lys Pro Val Gln Gln Pro Ala Asn Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Leu Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Ile Lys Thr Pro Thr Thr Thr Pro Val Thr Thr Lys Asn Thr Pro Thr 
                85                  90                  95      


Thr Ser Pro Ile Ile Tyr Thr Leu Val Thr Thr Gln Ala Thr Ser Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Leu Thr Lys Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Asn His Thr Thr Gly Asn Ala Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Pro 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Ser Thr Leu Ala Pro Gln Pro Ser Ser Ile Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Leu Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Asn Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Gly Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Cys Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Met Lys His Ala Val Val Met Phe Gln Thr Val Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Leu Lys Thr Thr Asn Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Val Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  47
<211>  428
<212>  PRT
<213>  Canis lupus familiaris

<400>  47

Met Ser Trp Gln Leu Ser Ala Ala Val Ala Leu Phe Val Ser Leu Ala 
1               5                   10                  15      


Leu Ile Leu His Tyr Gly Ser Gln Ile Arg Ala Lys Met Phe Pro Glu 
            20                  25                  30          


Thr Val Asp Phe Gln Pro Thr Thr Ala Ala Thr Val Arg Ala Thr Ala 
        35                  40                  45              


Lys Pro Phe Leu His Leu Thr Asn Gln Val Pro Ser Gln Thr Leu Ala 
    50                  55                  60                  


Ala Arg Ser Met Asp Gly His Ile Ala Ser Gln Arg Ala Ala Thr Thr 
65                  70                  75                  80  


Ser Ser Ser Glu Pro Pro Thr Thr His Thr Thr Val Lys Thr Leu Val 
                85                  90                  95      


Thr Thr Ser Leu Val Thr Ala Asn Ser Thr Pro Ser Ser Ser Pro Ile 
            100                 105                 110         


Ile Tyr Thr Leu Val Thr Thr Ile Val Thr Pro Asn Asn Ser Asn Thr 
        115                 120                 125             


Ala Ala Pro Val Thr Glu Ala Thr Ile Gly Pro Ser Ala Asp Pro Gly 
    130                 135                 140                 


Ser Leu Pro Thr Thr Ser Thr Pro Leu Ala His Thr Thr Arg Thr Asn 
145                 150                 155                 160 


Pro Ser Thr Leu Ser His Lys Thr Arg Lys Thr Thr His Phe Gly Asn 
                165                 170                 175     


Gln Thr Thr Leu Pro Ala Thr Leu Ser Thr Ser Thr His Lys Ser Thr 
            180                 185                 190         


Ser Ser His Lys Ser Ala Gln Ser Thr His Ala Pro Gly Pro Thr Thr 
        195                 200                 205             


Ala Ala His Asn Thr Thr Gln Thr Ala Ser Pro Ala Thr Pro Ala Ser 
    210                 215                 220                 


Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Pro Lys Thr Gly Ile Tyr 
225                 230                 235                 240 


Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala Glu Met Gly Ile 
                245                 250                 255     


Glu Leu Met Val Gln Asp Thr Lys Ser Val Phe Ser Pro Gln Arg Tyr 
            260                 265                 270         


Phe Asn Ile Asp Pro Asn Ala Thr Gln Thr Ser Gly Asn Cys Gly Ser 
        275                 280                 285             


Gln Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly Phe Val Asn Leu 
    290                 295                 300                 


Thr Phe Leu Lys Asp Glu Asn Ser Tyr Tyr Ile Asn Glu Val Gly Ala 
305                 310                 315                 320 


Tyr Leu Ala Val Ser Asn Pro Glu Lys Ile Tyr Gln Gly Met Lys Ser 
                325                 330                 335     


Ser Val Val Met Phe Glu Thr Gly Val Gly His Ser Phe Lys Cys Val 
            340                 345                 350         


Ser Glu Gln Ser Ile Gln Leu Ser Thr His Leu Gln Leu Lys Thr Met 
        355                 360                 365             


Asn Val Gln Phe Gln Ala Phe Asp Phe Glu Asp Asp His Phe Gly Asn 
    370                 375                 380                 


Val Asp Glu Cys Ser Ser Asp Tyr Thr Val Val Leu Pro Val Ile Gly 
385                 390                 395                 400 


Ala Ile Val Leu Gly Leu Cys Ala Val Gly Leu Ile Val Tyr Gly Ile 
                405                 410                 415     


His Leu Arg Arg Glu Ser Ser Gly Tyr Gln Arg Ile 
            420                 425             


<210>  48
<211>  430
<212>  PRT
<213>  Sus scrofa

<400>  48

Met Ser Trp Arg Leu Ser Ala Val Leu Val Ser Phe Val Ser Leu Ala 
1               5                   10                  15      


Val Phe Leu His Tyr Gly His His Met Lys Ala Lys Val Phe Pro Glu 
            20                  25                  30          


Ile Thr Asp Ser Ser Ser Pro Thr Thr Ala Ala Thr Val Gln Ala Thr 
        35                  40                  45              


Ala Glu Pro Ser Leu Trp Lys Pro Thr Asn His Thr Pro His Lys Thr 
    50                  55                  60                  


Leu Ala Ala Lys Ser Thr Asp Gly His Val Thr Ser Gln Ile Ala Thr 
65                  70                  75                  80  


Thr Val Thr Asp Ser Glu Thr Leu Thr Thr His Thr Thr Ile Thr Thr 
                85                  90                  95      


Leu Ala Ala Thr Ser Leu Ala Ala Thr Asn Ser Thr Pro Ser Thr Ser 
            100                 105                 110         


Pro Thr Thr His Thr Leu Phe Thr Thr Leu Ala Thr Pro Asn Thr Ser 
        115                 120                 125             


His Met Ala Ala Pro Val Thr Glu Ala Ala Ile Ser Pro Ser Ala Gly 
    130                 135                 140                 


Leu Ser Ser Leu Leu Pro Thr Ile Ile Pro Pro Ala His Thr Thr Gly 
145                 150                 155                 160 


Thr Arg Ser Ser Thr Leu Ser Pro Thr Ala Gly Lys Thr Thr Gln Pro 
                165                 170                 175     


Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Thr Ser Pro His Asn 
            180                 185                 190         


Ser Thr Ala Ser Gln Lys Pro Thr His Pro Asn His Thr Pro Gly Pro 
        195                 200                 205             


Thr Thr Gly Ala His Asn Thr Thr Gln Thr Ala Ser Pro Ala Thr Ile 
    210                 215                 220                 


Ala Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Ala Lys Thr Gly 
225                 230                 235                 240 


Ile Tyr Gln Val Leu Asn Gly Ser Lys Leu Cys Ile Lys Ala Glu Met 
                245                 250                 255     


Gly Ile Glu Leu Thr Val Gln Asp Thr Gln Ser Val Phe Ser Pro Gln 
            260                 265                 270         


Arg Tyr Phe Asn Ile Asp Pro Asn Thr Thr Gln Ala Ser Gly Asn Cys 
        275                 280                 285             


Gly Ser Arg Lys Ser Lys Leu Leu Leu Asn Phe Gln Gly Gly Phe Val 
    290                 295                 300                 


Asn Leu Thr Phe Thr Lys Asp Glu Asn Ser Tyr Tyr Val Ser Gly Val 
305                 310                 315                 320 


Gly Ala Tyr Leu Thr Val Ser Asn Pro Glu Lys Val Tyr Gln Gly Met 
                325                 330                 335     


Lys Asn Ala Val Val Met Phe Glu Thr Met Ile Gly His Ser Phe Lys 
            340                 345                 350         


Cys Val Ser Glu Gln Ser Ile Gln Leu Ser Pro His Leu Gln Leu Asn 
        355                 360                 365             


Thr Met Asn Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp His Phe 
    370                 375                 380                 


Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu Pro Val 
385                 390                 395                 400 


Ile Gly Ala Ile Val Leu Gly Leu Cys Ala Val Gly Leu Ile Val Tyr 
                405                 410                 415     


Gly Ile Arg Leu Lys Arg Glu Ser Ser Glu Tyr Gln Arg Ile 
            420                 425                 430 


<210>  49
<211>  259
<212>  PRT
<213>  Danio rerio

<400>  49

Met Thr Gln Ser Ser Arg Ser Val Leu Leu Leu Met Leu Ser Ser Leu 
1               5                   10                  15      


His Cys Leu Gly Ser Ser Leu Glu Ser Asn Pro Lys Asp Pro Ser Val 
            20                  25                  30          


Leu Ala Glu Ala Pro Gly Gln Asn Lys Arg Asp Ser Asp Ile Ser Leu 
        35                  40                  45              


Val Pro Gln Met Pro Val Leu Gln Pro Lys Glu Thr Ala Pro Pro Leu 
    50                  55                  60                  


Val Thr Tyr Thr Ile Arg Asn Pro Gln Gly Lys Val Cys Val Arg Ala 
65                  70                  75                  80  


Ser Phe Gly Val Glu Phe Val Val Arg Glu Asn Lys Lys Lys Tyr Tyr 
                85                  90                  95      


Phe Asn Leu Thr Pro Asn Ser Ala Arg Ala Thr Gly Tyr Cys Ala Asn 
            100                 105                 110         


Gln Lys Thr Val Leu Ser Leu Glu Phe Ser Gly Gly Asn Leu Glu Phe 
        115                 120                 125             


Thr Phe Ile Lys Asp Gly Asp Gln Ser Tyr Val Lys Thr Val Lys Gly 
    130                 135                 140                 


Ser Leu Arg Ala Ala Pro Pro Cys Lys Asn Cys Pro Ser Lys Ile Tyr 
145                 150                 155                 160 


Val Gly Leu Val Asp Asn Glu Lys Leu Phe Lys Ala Lys Asn Gly Leu 
                165                 170                 175     


Ser Phe Asn Cys Lys Ser Glu Thr Met Leu Ile Leu Ala Asp Tyr Phe 
            180                 185                 190         


Arg Leu Lys Leu Val Pro Leu Gln Ile Gln Ala Phe Asp Leu Val Asn 
        195                 200                 205             


Gly Ala Phe Gly Lys Glu Val Glu Cys Trp Ala Asp Tyr Asn Lys Arg 
    210                 215                 220                 


Met Ile Pro Ile Ile Leu Gly Ala Val Ala Ala Ala Ile Cys Leu Ile 
225                 230                 235                 240 


Ala Ile Leu Thr Tyr Val Leu Val Arg Glu His Arg Asn Gln Gly Tyr 
                245                 250                 255     


Glu Gln Leu 
            


<210>  50
<211>  432
<212>  PRT
<213>  Equus caballus

<400>  50

Met Ala Trp Gln Leu Ser Ala Val Val Val Leu Phe Val Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu Tyr Tyr Gly Ser His Val Arg Ala Asn Val Phe Pro Glu 
            20                  25                  30          


Ile Thr Asp Tyr Ser Gln Pro Thr Thr Ala Ala Thr Ile Gln Thr Arg 
        35                  40                  45              


Ala Gln Pro Ser Leu Ser Gln Pro Thr Asn Gln Val Pro His Lys Thr 
    50                  55                  60                  


Leu Ala Thr Arg Ser Met Asp Gly Gln Val Thr Ser Gln Thr Ala Ala 
65                  70                  75                  80  


Thr Thr Val Asn Pro Glu Thr Pro Val Thr His Thr Thr Ile Lys Thr 
                85                  90                  95      


Ala Ala Ala Thr Ser Leu Val Thr Thr Asn Ser Thr Leu Ser Thr Ser 
            100                 105                 110         


Pro Ile Thr Asn Thr Leu Leu Thr Thr Leu Ala Thr Pro Asp Asn Thr 
        115                 120                 125             


His Thr Thr Thr Pro Val Thr Glu Ala Thr Ile Gly Pro Ser Ala Gly 
    130                 135                 140                 


Pro Gly Ser Pro Pro Thr Thr Ile Thr Thr Thr Ser Ser Ala Tyr Thr 
145                 150                 155                 160 


Thr Gly Thr Arg Ser Ser Thr Val Ser His Thr Thr Gly Lys Thr Thr 
                165                 170                 175     


Gln Leu Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Thr Ser Pro 
            180                 185                 190         


His Asn Ser Thr Thr Ser Gln Asn Pro Ala His Ser Thr His Thr Pro 
        195                 200                 205             


Gly Pro Thr Thr Gly Thr Cys Asn Thr Thr Gln Thr Ala Ser Pro Thr 
    210                 215                 220                 


Thr Thr Ala Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Thr Gly Met Tyr Gln Ile Leu Asn Gly Ser Lys Leu Cys Ile Lys Ala 
                245                 250                 255     


Glu Met Gly Ile Gln Leu Thr Val Gln Asp Thr Lys Ser Ala Ser Pro 
            260                 265                 270         


Pro Gln Gly Tyr Phe Asn Ile Asp Pro Asn Thr Thr Gln Val Ser Gly 
        275                 280                 285             


Ile Cys Gly Ser Arg Lys Ser Asn Leu Leu Leu Asn Phe Trp Gly Gly 
    290                 295                 300                 


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Asn Ser Tyr Tyr Ile Ser 
305                 310                 315                 320 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asn Pro Glu Lys Thr Tyr Gln 
                325                 330                 335     


Gly Met Lys Ser Pro Val Val Met Phe Glu Thr Val Ile Gly His Ser 
            340                 345                 350         


Phe Lys Cys Val Ser Glu Gln Ser Leu Glu Leu Ser Thr Gln Leu His 
        355                 360                 365             


Leu Lys Thr Thr Asn Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
    370                 375                 380                 


Asn Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Val Val Leu 
385                 390                 395                 400 


Pro Val Ile Gly Ala Ile Val Leu Gly Leu Phe Ala Val Gly Leu Ile 
                405                 410                 415     


Val Tyr Gly Val Arg Val Arg Arg Glu Ala Ser Gly Tyr Gln Arg Ile 
            420                 425                 430         


<210>  51
<211>  433
<212>  PRT
<213>  Bos taurus

<400>  51

Met Ser Trp Gln Ile Pro Ala Val Val Met Ser Phe Met Ala Leu Val 
1               5                   10                  15      


Ala Ile Trp Tyr Tyr Asp Ser His Tyr Asn Ser His Met Gln Ala Lys 
            20                  25                  30          


Val Phe Pro Glu Ile Thr Gly Tyr Ser Ser Pro Thr Thr Gly Gln Ala 
        35                  40                  45              


Thr Val Lys Pro Ser Leu Leu Gln Pro Thr Asn Tyr Val Pro His Lys 
    50                  55                  60                  


Thr Ala Ala Ala Arg Ser Thr Asp Gly His Val Thr Ser Gln Thr Val 
65                  70                  75                  80  


Ala Lys Thr Ser Ser Ser Glu Thr Leu Thr Thr Asn Thr Thr Ile Asp 
                85                  90                  95      


Val Leu Ala Thr Thr Ser Pro Val Thr Thr Lys Ser Thr Leu Pro Thr 
            100                 105                 110         


Thr Pro Thr Thr His Thr Leu Val Thr Thr Leu Ala Thr Pro Asn Lys 
        115                 120                 125             


Ser His Val Thr Phe Pro Val Thr Glu Ala Lys Val Gly Leu Ser Val 
    130                 135                 140                 


Gly Pro Ser Ser Pro Pro Val Thr Val Asn Pro Thr Ala His Thr Thr 
145                 150                 155                 160 


Gly Asn Arg Pro Ser Thr Ala Ser His Thr Thr Gly Lys Thr Thr Gln 
                165                 170                 175     


Leu Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Thr Ser Pro His 
            180                 185                 190         


Asn Ile Thr Thr Ser Gln Lys Pro Thr Gln Pro Thr His Thr Pro Gly 
        195                 200                 205             


Pro Thr Thr Ala Thr Tyr Asn Thr Thr Gln Thr Ala Ser Pro Ala Thr 
    210                 215                 220                 


Ile Ala Pro Arg Pro Thr Leu Ala Pro Gln Pro Leu Ser Pro Lys Thr 
225                 230                 235                 240 


Gly Ile Tyr Gln Val His Asn Gly Ser Lys Leu Cys Ile Lys Ala Glu 
                245                 250                 255     


Met Gly Ile Gln Leu Thr Val Gln Asp Ser Val Ser Val Phe Ser Pro 
            260                 265                 270         


Gln Lys Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly Asn 
        275                 280                 285             


Cys Gly Ser Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly Phe 
    290                 295                 300                 


Val Asn Leu Thr Phe Thr Lys Gly Glu Lys Ser Tyr Tyr Ile Ser Glu 
305                 310                 315                 320 


Val Glu Ala Tyr Leu Thr Val Ser Asn Pro Ala Lys Val Tyr Gln Gly 
                325                 330                 335     


Leu Lys His Ala Met Met Met Phe Glu Thr Val Val Gly His Ser Phe 
            340                 345                 350         


Lys Cys Val Ser Glu Gln Ser Ile Gln Leu Ser Thr Tyr Leu Gln Leu 
        355                 360                 365             


Lys Thr Met Asn Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp His 
    370                 375                 380                 


Phe Gly Asn Ala Asp Glu Cys Ile Ser Asp Arg Asn Arg Arg Glu Ile 
385                 390                 395                 400 


Pro Val Ala Val Gly Leu Ser Ile Ala Val Leu Leu Ala Val Leu Leu 
                405                 410                 415     


Thr Ala Cys Leu Val Thr Arg Lys Arg Pro Ser Arg Gly Tyr Glu Arg 
            420                 425                 430         


Met 
    


<210>  52
<211>  429
<212>  PRT
<213>  Ovis aries

<400>  52

Met Ser Trp Gln Ile Ser Ala Val Val Leu Phe Phe Val Ser Leu Ala 
1               5                   10                  15      


Val Ile Trp Tyr Tyr Asp Ser His Met Lys Ala Asn Val Phe Pro Glu 
            20                  25                  30          


Ile Thr Gly Tyr Ser Ser Pro Thr Thr Gly Gln Ala Thr Val Lys Pro 
        35                  40                  45              


Ser Leu Leu Gln Pro Thr Asn His Val Pro Cys Asn Thr Ala Ala Ala 
    50                  55                  60                  


Lys Ser Thr Asp Gly His Val Thr Ser Gln Thr Val Ala Lys Thr Ser 
65                  70                  75                  80  


Ser Pro Glu Thr Leu Thr Thr Asn Thr Thr Ile Glu Val Leu Val Thr 
                85                  90                  95      


Thr Ser Pro Val Thr Thr Gln Ser Thr Leu Pro Thr Thr Pro Thr Thr 
            100                 105                 110         


His Thr Leu Val Thr Thr Leu Ala Thr Pro Ser Lys Ser His Val Thr 
        115                 120                 125             


Phe Pro Val Thr Glu Ala Lys Ala Gly Leu Ser Ile Gly Pro Ser Ser 
    130                 135                 140                 


Pro Pro Val Thr Ile Asn Pro Ala Ala His Thr Thr Gly Asn Arg Pro 
145                 150                 155                 160 


Ser Thr Ala Ser His Thr Thr Gly Lys Thr Thr Gln Leu Ser Asn Gln 
                165                 170                 175     


Thr Thr Leu Pro Ala Thr Leu Ser Thr Ser Pro His Asn Ile Thr Thr 
            180                 185                 190         


Ser Gln Lys Pro Thr Gln Pro Thr His Thr Pro Gly Pro Thr Thr Ala 
        195                 200                 205             


Ala Asn Asn Thr Thr His Thr Ala Ser Pro Ala Thr Ile Ala Pro Arg 
    210                 215                 220                 


Pro Thr Leu Ala Pro Gln Pro Leu Ser Pro Lys Thr Gly Leu Tyr Gln 
225                 230                 235                 240 


Val Leu Asn Gly Ser Lys Leu Cys Ile Lys Ala Glu Met Gly Ile Gln 
                245                 250                 255     


Leu Thr Val Gln Asp Ser Val Ser Val Phe Ser Pro Gln Lys Tyr Phe 
            260                 265                 270         


Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly Asn Cys Gly Ser Arg 
        275                 280                 285             


Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly Phe Val Asn Leu Thr 
    290                 295                 300                 


Phe Ile Lys Asp Glu Asn Ser Tyr Tyr Ile Ser Glu Val Glu Ala Tyr 
305                 310                 315                 320 


Leu Thr Val Ser Asn Pro Ala Lys Val Tyr Gln Gly Met Lys Tyr Ala 
                325                 330                 335     


Met Met Met Phe Glu Thr Val Val Gly His Ser Phe Lys Cys Val Ser 
            340                 345                 350         


Glu Gln Ser Ile Gln Leu Ser Asn His Leu Gln Leu Lys Thr Val Asn 
        355                 360                 365             


Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp Arg Phe Gly Asn Ala 
    370                 375                 380                 


Asp Glu Cys Ile Ser Asp Arg Asn Arg Arg Glu Ile Pro Val Ala Val 
385                 390                 395                 400 


Gly Leu Ser Ile Ala Val Leu Leu Ala Val Leu Leu Thr Ala Cys Leu 
                405                 410                 415     


Val Thr Arg Lys Arg Pro Ser Arg Gly Tyr Glu Arg Met 
            420                 425                 


<210>  53
<211>  408
<212>  PRT
<213>  Rattus norvegicus

<400>  53

Met Pro Gly Gln Thr Ser Ala Val Ala Val Leu Leu Cys Leu Ala Val 
1               5                   10                  15      


Ile Leu His Gly Tyr Gln Ile Arg Glu Lys Glu Phe Pro Glu Ala Arg 
            20                  25                  30          


Gly Tyr Leu Gln Tyr Thr Ala Thr Thr Thr Glu Gln Ile Thr Ala Lys 
        35                  40                  45              


Pro Pro Leu Pro Leu Thr Asn Gln Thr Ser His Ala Thr Leu Ala Ser 
    50                  55                  60                  


Arg Ser Lys Asp Asp Tyr Ile Gln Thr Ala Ala Glu Thr Ser Thr Phe 
65                  70                  75                  80  


Glu Asp Thr Ala His Ile Thr Met Lys Thr Ala Ile Pro Val Thr Thr 
                85                  90                  95      


Lys Ser Leu Leu Pro Ile Ser Ser Thr Ser Tyr Thr Phe Val Arg Thr 
            100                 105                 110         


Asn Asn Ser His Met Thr Ala Ser Ser Thr Glu Asp Thr Ile Gly Ser 
        115                 120                 125             


Gly Ser Ile Thr His Leu Pro Phe Pro Thr Thr Arg Ala Ser Leu Ala 
    130                 135                 140                 


Ala Val Asn His Ile Thr Gly Arg Ser Thr Gln Leu Gly Gly Gln Thr 
145                 150                 155                 160 


Thr Leu Pro Lys Ala Leu Phe Thr Pro Ser His Glu Ser Thr Thr Thr 
                165                 170                 175     


Gln Arg Pro Thr Leu Ser Thr Ile Val Ser Glu Leu Thr Pro Thr Gly 
            180                 185                 190         


Lys Asp Arg Ser Thr Thr Ser Ser Val Pro Leu Val Pro Arg Pro Thr 
        195                 200                 205             


Phe Val Thr Trp Ser Ser Pro Ala Lys Ile Gly Thr Tyr Glu Val Leu 
    210                 215                 220                 


Asn Gly Ser Arg Leu Cys Ile Lys Ala Glu Met Gly Ile Ala Leu Ile 
225                 230                 235                 240 


Val Gln Glu Lys Gly Leu Asp Ser Ala Thr Gln Arg His Phe Asn Ile 
                245                 250                 255     


Asp Pro Ser Leu Thr His Ala Ser Gly Lys Cys Gly Ser Gln Asn Ser 
            260                 265                 270         


Asn Leu Phe Leu Asn Phe Gln Gly Gly Ser Val Asn Val Thr Phe Thr 
        275                 280                 285             


Lys Glu Glu Asn Leu Tyr Tyr Val Ser Glu Val Gly Ala Tyr Leu Thr 
    290                 295                 300                 


Ile Ser Asn Thr Glu Lys Thr Tyr Gln Gly Lys Ser Thr Met Met Met 
305                 310                 315                 320 


Phe Glu Thr Val Val Gly His Ser Phe Lys Cys Val Ser Glu Gln Ser 
                325                 330                 335     


Ile Gln Leu Ser Ala Gln Leu Gln Met Lys Thr Met Asn Ile His Leu 
            340                 345                 350         


Gln Ala Phe Asp Phe Glu Gly Asp Ser Phe Gly Ile Val Asp Glu Cys 
        355                 360                 365             


Leu Ser Asp Tyr Thr Val Val Leu Pro Val Val Gly Ile Ile Val Val 
    370                 375                 380                 


Val Leu Cys Val Val Gly Leu Gly Ile Tyr Lys Ile Arg Gln Arg Arg 
385                 390                 395                 400 


Gln Ser Ser Ala Tyr Gln Arg Ile 
                405             


<210>  54
<211>  411
<212>  PRT
<213>  Mus musculus

<400>  54

Met Pro Gly Gln Ile Ser Ala Val Ala Val Leu Phe Leu Ser Leu Thr 
1               5                   10                  15      


Val Ile Leu His Gly Tyr Gln Ile Arg Glu Lys Glu Phe Pro Lys Ala 
            20                  25                  30          


Arg Gly Tyr Leu Gln Tyr Thr Ala Thr Ser Ala Glu Gln Ile Thr Thr 
        35                  40                  45              


Lys Pro Leu Leu Gln Leu Ile Asn Gln Arg Ser His Ile Thr Leu Ala 
    50                  55                  60                  


Ser Arg Phe Lys Asp Asp Tyr Ile Gln Met Ala Ala Glu Thr Ser Ala 
65                  70                  75                  80  


Ile Glu Asn Thr Ala His Ile Thr Met Lys Thr Val Thr Pro Val Thr 
                85                  90                  95      


Thr Lys Ser Leu Pro Pro Ile Ser Ser Ala Ser Tyr Thr Phe Val Arg 
            100                 105                 110         


Ser Asn Asn Ala His Met Thr Ala Ser Ser Thr Asp Asp Thr Ile Gly 
        115                 120                 125             


Ser Gly Ser Ile Ala His Leu Pro Val Pro Thr Thr Arg Ala Ser Leu 
    130                 135                 140                 


Ala Ile Val Asn Tyr Ile Thr Gly Arg Ala Thr Gln Leu Gly Gly Gln 
145                 150                 155                 160 


Thr Thr Leu Pro Lys Thr Phe Phe Thr Ala Ser His Lys Ser Thr Thr 
                165                 170                 175     


Asn Gln Arg Pro Thr Leu Ser Thr Asn Val Leu Gly Thr Ser Thr Pro 
            180                 185                 190         


Thr His Lys Asp Arg Ser Thr Thr Ser Pro Val Pro Leu Val Pro Arg 
        195                 200                 205             


Pro Thr Leu Val Thr Trp Ser Ser Pro Ala Lys Ile Gly Thr Tyr Glu 
    210                 215                 220                 


Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala Glu Met Gly Leu Ala 
225                 230                 235                 240 


Leu Ile Val Gln Glu Lys Asp Leu Asp Ser Ala Thr Gln Arg Tyr Phe 
                245                 250                 255     


Asn Ile Asp Pro Ser Leu Thr His Ala Ser Gly Lys Cys Asp Ser Gln 
            260                 265                 270         


Lys Ser Asn Leu Phe Leu Asn Phe Gln Gly Gly Ser Val Asn Ile Thr 
        275                 280                 285             


Phe Thr Lys Glu Glu Asn Leu Tyr Tyr Ile Ser Glu Val Gly Ala Tyr 
    290                 295                 300                 


Leu Thr Ile Ser Asn Thr Glu Lys Thr Tyr Gln Gly Lys Lys Asn Thr 
305                 310                 315                 320 


Leu Met Met Phe Glu Thr Val Val Gly His Ser Phe Lys Cys Val Ser 
                325                 330                 335     


Glu Gln Ser Ile Gln Leu Ser Ala Gln Leu Gln Met Lys Thr Met Asn 
            340                 345                 350         


Ile His Leu Gln Ala Phe Asp Phe Glu Gly Asp Ser Phe Gly Asn Val 
        355                 360                 365             


Asn Glu Cys Leu Ser Asp Tyr Thr Val Val Leu Pro Met Val Ala Ile 
    370                 375                 380                 


Ile Val Val Val Ile Cys Val Val Gly Leu Ser Val Tyr Lys Ile Arg 
385                 390                 395                 400 


Gln Arg His Gln Ser Ser Ala Tyr Gln Arg Ile 
                405                 410     


<210>  55
<211>  314
<212>  PRT
<213>  Xenopus tropicalis

<400>  55

Met Asp Arg Val Ser Leu Leu Ser Thr Ile Leu Leu Leu Tyr Gly Leu 
1               5                   10                  15      


Leu Tyr Ile Asn Asp Ala Tyr Ser Glu Asn Thr Phe Ala Gln Pro Ser 
            20                  25                  30          


Asn Thr Thr Thr Pro Ala Pro Asn Thr Thr Thr Thr His Val Thr Ser 
        35                  40                  45              


Asn Thr Thr Thr Leu Ala Pro Asn Thr Thr Thr Thr His Val Thr Ser 
    50                  55                  60                  


Asn Thr Thr Thr Leu Ala Pro Asn Thr Thr Thr Thr His Ile Thr Ser 
65                  70                  75                  80  


Asn Thr Thr Thr Leu Ala Pro Asn Thr Thr Thr Thr Leu Ala Pro Asn 
                85                  90                  95      


Thr Thr Thr Thr His Ser Val Thr Thr Thr Lys Thr Ala Ser Thr Thr 
            100                 105                 110         


Thr Pro Thr Pro Thr Leu Glu Pro Lys Pro Ser Pro Pro Glu Thr Gly 
        115                 120                 125             


Asn Tyr Thr Val Lys Ile Lys Asn Glu Phe Cys Ile Glu Ala Leu Met 
    130                 135                 140                 


Gly Leu Glu Leu Glu Leu Thr Asn Ser Thr Lys Thr Gln Gln Tyr Phe 
145                 150                 155                 160 


Asn Ile Val Pro Ser Gln Ile Asn Ser Asn Gly Thr Cys Glu Lys Ser 
                165                 170                 175     


Lys Ala Asn Leu Asn Leu Thr Phe Ala Asn Ser Tyr Ile Asn Phe Val 
            180                 185                 190         


Phe Ala Gln Asp Asp Asn Ser Tyr Tyr Leu Asp Asn Val Thr Val Tyr 
        195                 200                 205             


Phe Asn Leu Thr Arg Ser Glu Ser Trp Tyr Gly Asn Ala Thr Asn Gln 
    210                 215                 220                 


Lys Leu Leu Lys Thr Glu Asn Gly Tyr Ser Val Lys Cys Lys Asn Thr 
225                 230                 235                 240 


Pro Lys Ile Gln Leu Gly Asp Thr Met Asn Leu Val Met Thr Asn Val 
                245                 250                 255     


Lys Leu Gln Val Phe Asn Phe Lys Asp Asn Ser Phe Gly Lys Glu Thr 
            260                 265                 270         


Thr Cys Lys Tyr Asp His Asn Phe Gly Leu Met Ile Ala Gly Ile Val 
        275                 280                 285             


Ile Val Val Ile Val Val Leu Gly Val Ile Ile Tyr Phe Ile Trp His 
    290                 295                 300                 


Lys Arg Lys Ser Ser Gly Tyr Gln Arg Ile 
305                 310                 


<210>  56
<211>  478
<212>  PRT
<213>  Pan troglodytes

<400>  56

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Glu Trp Ser Gln Val Arg Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 
            180                 185                 190         


Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala 
            340                 345                 350         


Ile Glu Gly Met His Pro Asn Lys Glu Asp His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  57
<211>  478
<212>  PRT
<213>  Macaca mulatta

<400>  57

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Val Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 
            180                 185                 190         


Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala 
            340                 345                 350         


Ile Glu Gly Met His Pro Asn Lys Glu Asp His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val Leu 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Val Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Phe Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  58
<211>  478
<212>  PRT
<213>  Canis lupus familiaris

<400>  58

Met Gly Arg Cys Cys Phe Tyr Thr Val Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Ile Ala Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Thr Ile Glu Lys Asn Ile Val Leu Arg Asn Gly Ser Glu 
        35                  40                  45              


Thr Phe Asp Ser Trp Lys Lys Pro Pro Leu Pro Val Tyr Ala Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Ile 
65                  70                  75                  80  


Pro Arg Leu Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asp 
                85                  90                  95      


Lys Ala Asp Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asn Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Thr Asp Leu Ile Arg Thr Leu Asn Ile Pro Ala Val Thr Ala Met 
    130                 135                 140                 


Glu Trp Ala His Leu His Phe Phe Arg Glu Leu Ile Glu Ala Leu Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Thr Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile Asn Val Phe Lys 
            180                 185                 190         


Pro Glu Ile Ser Pro Tyr Phe Gly Leu Tyr Tyr Gly Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn 
    210                 215                 220                 


Phe Ser Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Thr Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Asp Lys Asp Glu Ile Leu Tyr Val Phe Pro Ser Glu 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Phe Lys Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Gly Glu Val Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Val Pro Lys Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Ile Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Ile Ser Phe Pro His Phe Tyr Glu Ala Asp Lys Lys Phe Val Ser Ala 
            340                 345                 350         


Ile Asp Gly Met Arg Pro Asn Lys Asp Tyr His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Arg Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Val Tyr Val Lys Lys Leu Asp Asp Phe Ile Glu Thr Gly Asn 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Ile Asn Glu Ser Val Leu 
                405                 410                 415     


Ile Asp Lys Asp Thr Ala Ser Arg Leu Lys Ser Val Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Ile Thr Asn Ile Pro Tyr Ile Val Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Ile Phe Thr Trp Leu Ala Cys Arg Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Pro Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  59
<211>  478
<212>  PRT
<213>  Bos taurus

<400>  59

Met Gly Arg Cys Cys Phe Tyr Ala Val Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Ile Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Thr Ile Glu Lys Asn Ile Val Leu Arg Asn Gly Ser Glu 
        35                  40                  45              


Thr Phe Asp Ser Trp Lys Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Asn Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Leu Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Asp Asp Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Lys Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Leu Arg Thr Leu Asn Ile Pro Ala Leu Thr Ala Met 
    130                 135                 140                 


Glu Trp Thr Gln Leu Pro Leu Leu Arg Asp Ile Ile Glu Ala Leu Leu 
145                 150                 155                 160 


Lys Ala Tyr Arg Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile Asn Thr Phe Lys 
            180                 185                 190         


His Asp Val Ser Pro Tyr Phe Gly Leu Phe Tyr Gly Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn 
    210                 215                 220                 


Phe Ser Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Thr Ala Asp Glu Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Thr Phe 
                245                 250                 255     


His Pro Leu Ile Thr Arg Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Phe Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Leu Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Lys Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Val Ser Val Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Lys Phe Val Ser Ala 
            340                 345                 350         


Ile Gly Gly Met His Pro Asn Lys Glu Tyr His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Arg Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Val Tyr Val Arg Lys Leu Asp Asp Phe Val Glu Thr Gly Asn 
385                 390                 395                 400 


Ile Gln Thr Leu Val Phe Pro Val Met Tyr Ile Asn Glu Ser Val Leu 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Val Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Val Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Ile Phe Thr Trp Leu Ala Cys Arg Gly Gln Gly Ser Thr 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  60
<211>  478
<212>  PRT
<213>  Mus musculus

<400>  60

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Thr Ile Glu Lys Asn Met Val Leu Gln Asn Gly Thr Lys 
        35                  40                  45              


Val Phe Asn Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Ile Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Gln Gly Glu Ile 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Ile Gln Phe Gly Glu Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Thr Asn Lys Ala Tyr Val Phe Glu Arg Asn Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Asn Val Asp Leu Ile Arg Thr Ile Asn Ile Pro Leu Leu Thr Val Val 
    130                 135                 140                 


Asp Leu Ala Gln Leu Thr Leu Leu Arg Glu Leu Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Ile His Thr Val His Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Val His Ile Phe Lys 
            180                 185                 190         


Pro Asp Val Ser Pro Asn Phe Gly Leu Phe Tyr Glu Arg Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Glu Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn 
    210                 215                 220                 


Phe Ser Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Thr Thr Asp Thr Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Ser Lys Asp Glu Val Leu Tyr Leu Phe Pro Ser Asp 
            260                 265                 270         


Leu Cys Arg Ser Val His Ile Thr Phe Ser Ser Phe Glu Asn Val Glu 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Glu Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Met Asp 
305                 310                 315                 320 


Ser Gly Val Leu Asn Ile Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Lys Phe Val Ser Ala 
            340                 345                 350         


Ile Lys Gly Met His Pro Asn Lys Glu Glu His Glu Ser Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Arg Gly Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Thr Tyr Val Arg Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val Leu 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Asn Gln Leu Lys Ser Val Ile Asn Thr Thr 
            420                 425                 430         


Leu Val Val Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Arg Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  61
<211>  531
<212>  PRT
<213>  Danio rerio

<400>  61

Met Thr Arg Arg Ser Cys Thr Ile Tyr Ala Thr Gly Ile Val Cys Ala 
1               5                   10                  15      


His Leu Leu Ile Leu Gly Ile Ala Leu Leu Leu Ala Gln Val Phe Gln 
            20                  25                  30          


Thr Met Ile Gln Glu Arg Ile Lys Lys Glu Ile Thr Leu Ala Glu Asn 
        35                  40                  45              


Ser Arg Val Leu Asp Gly Trp Ile Asn Pro Pro Pro Pro Val Tyr Met 
    50                  55                  60                  


Gln Tyr Phe Phe Phe Asn Val Thr Asn Pro Asp Glu Phe Leu Ala Gly 
65                  70                  75                  80  


Lys Glu Lys Ala Lys Val Thr Gln Met Gly Pro Tyr Thr Tyr Arg Glu 
                85                  90                  95      


Tyr Arg Pro Arg Glu Asn Val Thr Tyr Leu Glu Asn Gly Thr Lys Ile 
            100                 105                 110         


Phe Ala Thr Asn Pro Lys Ser Phe Val Phe Leu Arg Asn Met Ser Ala 
        115                 120                 125             


Gly Asp Pro Glu Val Asp Arg Val Thr Thr Val Asn Ile Pro Met Ile 
    130                 135                 140                 


Ala Val Met Asn Glu Leu Asn Ser Tyr Ser Phe Phe Val Arg Thr Ala 
145                 150                 155                 160 


Val Ser Met Tyr Met Gly Ser Met Gly Met Gly Leu Phe Met Asn Arg 
                165                 170                 175     


Thr Val His Glu Ile Leu Trp Gly Phe Lys Asp Pro Leu Leu Thr Lys 
            180                 185                 190         


Leu His Ala Met Arg Pro Glu Val Asp Glu His Phe Gly Leu Met Tyr 
        195                 200                 205             


Asn Lys Asn Gly Thr His Glu Gly Glu Phe Val Phe His Thr Gly Glu 
    210                 215                 220                 


Lys Asn Tyr Met Asn Tyr Gly Lys Ile Asp Thr Trp Asn Gly Ile Ser 
225                 230                 235                 240 


Gln Met Asn Trp Trp Ser Ser Asn Gln Ser Asn Met Ile Asn Gly Thr 
                245                 250                 255     


Asp Gly Ser Val Phe His Thr Phe Leu Ser Arg Lys Glu Leu Leu Tyr 
            260                 265                 270         


Ile Phe Ala Ala Asp Leu Cys Arg Ser Ile His Leu Gly Tyr Val Arg 
        275                 280                 285             


Asp Met Glu Val Lys Gly Ile Pro Ala Phe Arg Phe Ala Pro Pro Ser 
    290                 295                 300                 


Asp Val Leu Ala Pro Pro Asp Glu Asn Pro Ala Asn Ala Gly Phe Cys 
305                 310                 315                 320 


Val Pro Ala Gly Asp Cys Leu Gly Lys Gly Val Leu Lys Val Ser Val 
                325                 330                 335     


Cys Arg Gln Gly Ala Pro Ile Val Val Ser Phe Pro His Phe Tyr Gln 
            340                 345                 350         


Ala Asp Glu Arg Tyr Ile Asn Ala Ile Glu Gly Met Asn Pro Asn Glu 
        355                 360                 365             


Glu Glu His Glu Thr Tyr Leu Asp Ile Asn Pro Thr Thr Gly Val Pro 
    370                 375                 380                 


Ile Arg Ala Cys Lys Arg Ala Gln Leu Asn Ile Ile Leu Lys Arg Val 
385                 390                 395                 400 


Arg Gly Phe Pro Asn Thr Lys Phe Leu Asn Glu Thr Ile Phe Pro Ile 
                405                 410                 415     


Met Tyr Val Asn Glu Thr Ala Thr Ile Asp Asp Glu Ser Ala Ala Gln 
            420                 425                 430         


Met Arg Met Leu Leu Leu Ile Val Thr Val Val Ser Asn Phe Pro Val 
        435                 440                 445             


Ile Ile Leu Ala Leu Gly Val Ile Leu Leu Val Val Leu Ile Phe Leu 
    450                 455                 460                 


Val Cys Arg Asn Arg Gln Arg Lys Asn Glu Val Lys Arg Ile Asp Phe 
465                 470                 475                 480 


Thr Glu Ala Phe His Ser Phe Ala Thr Thr Lys Asp Glu Thr Ala Tyr 
                485                 490                 495     


Thr Gln Val Ser Asn Gln Ala Glu Asp Ser Pro Glu Asn Arg Asn Asn 
            500                 505                 510         


Gln Pro Leu Arg Asn Gly Ser Tyr Ile Ala Met Ser Pro Val Glu Ala 
        515                 520                 525             


Gln Lys Cys 
    530     


<210>  62
<211>  478
<212>  PRT
<213>  Rattus norvegicus

<400>  62

Met Ala Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Thr Ile Glu Lys Asn Met Val Leu Gln Asn Gly Thr Lys 
        35                  40                  45              


Val Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Ile Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Gln Gly Glu Ile 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Val Gln Phe Gly Glu Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Thr Asn Lys Ala Tyr Ile Phe Glu Arg Asn Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Thr Val Asp Leu Ile Arg Thr Ile Asn Ile Pro Leu Leu Thr Val Val 
    130                 135                 140                 


Glu Met Ala Gln Gln Pro Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Thr Leu Phe Val Thr His Thr Val His Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Val Leu Ser Leu Val His Ile Phe Arg 
            180                 185                 190         


Pro Asp Val Ser Pro Asn Phe Gly Leu Phe Tyr Glu Arg Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Glu Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Thr Thr Asp Thr Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Ser Lys Asp Glu Thr Leu Tyr Ile Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Ser Phe Glu Asn Val Glu 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Ser Ser Glu Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Met Asp 
305                 310                 315                 320 


Ala Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Lys Phe Val Ser Ala 
            340                 345                 350         


Ile Lys Gly Met Arg Pro Asn Lys Glu Glu His Glu Ser Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Arg Gly Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Thr Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asn 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val Leu 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Gln Leu Lys Ser Val Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Val Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Ile Phe Thr Trp Leu Ala Cys Arg Gly Gln Gly Ser Thr 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  63
<211>  481
<212>  PRT
<213>  Gallus gallus

<400>  63

Met Arg Ser Leu Cys Leu Val Thr Val Gly Val Leu Ala Leu Thr Leu 
1               5                   10                  15      


Leu Ile Ala Ser Ile Ser Leu Leu Val Ala His Val Phe Gln Thr Val 
            20                  25                  30          


Val Asp Leu Gln Val Lys Gln Gly Thr Val Leu Lys Asn Gly Thr Glu 
        35                  40                  45              


Thr Phe Glu Ala Trp Glu Asp Pro Pro Pro Pro Val Tyr Met Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Leu Glu Val Leu Gln Gly Ala Thr 
65                  70                  75                  80  


Pro Leu Val Glu Glu Lys Gly Pro Tyr Thr Tyr Arg Glu Tyr Arg Pro 
                85                  90                  95      


Arg Val His Val Gln Phe Leu Asp Asn Gly Thr Lys Val Ser Ala Leu 
            100                 105                 110         


Asn Pro Lys Thr Tyr Val Phe Glu Pro Glu Lys Ser Val Gly Asn Pro 
        115                 120                 125             


Glu Val Asp Leu Ile Arg Thr Ile Asn Val Pro Ala Val Thr Ala Met 
    130                 135                 140                 


Glu Trp Thr Arg Ala Thr Ser Leu Gln Phe Ala Thr Glu Val Leu Leu 
145                 150                 155                 160 


Leu Leu Tyr Gln Glu Ser Leu Phe Thr Val Arg Thr Val His Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Lys Leu Leu Ser Thr Ile His Val Leu His 
            180                 185                 190         


Pro Glu Ile Asp Pro Val Phe Gly Phe Phe Asn Lys Met Asn Gly Thr 
        195                 200                 205             


Asp Asp Gly Glu Tyr Val Phe Leu Ser Gly Glu Met Asn Tyr Leu Asn 
    210                 215                 220                 


Phe Ser Arg Ile Val Glu Trp Lys Gly Lys Glu Ser Leu Asn Trp Trp 
225                 230                 235                 240 


Thr Thr Lys Thr Cys Asn Met Ile Asn Gly Thr Asp Gly Thr Ser Phe 
                245                 250                 255     


His Pro Leu Ile Ser Lys Asp Glu Asn Ile Tyr Ile Phe Ser Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Leu Tyr Leu Val Tyr Asp Ser Ser Gly Ser Val Ala 
        275                 280                 285             


Gly Val Pro Thr Tyr Arg Phe Val Pro Ser Pro Met Val Phe Ala Asn 
    290                 295                 300                 


Thr Thr Val Asn Pro Asp Asn Ala Gly Phe Cys Val Pro Pro Gly Asn 
305                 310                 315                 320 


Cys Pro Gly Ala Gly Val Leu Asn Val Ser Ile Cys Lys Gln Gly Ala 
                325                 330                 335     


Pro Ile Phe Leu Ser Ala Pro His Phe Tyr Gln Ala Asp Gln Lys Phe 
            340                 345                 350         


Val Ser Asp Ile Glu Gly Met His Pro Thr Lys Glu Tyr His Glu Thr 
        355                 360                 365             


Phe Val Asp Ile Asn Pro Leu Thr Gly Leu Val Leu Gln Ala Ala Lys 
    370                 375                 380                 


Arg Met Gln Ile Asn Ile His Val Arg Lys Leu Pro Glu Phe Phe Glu 
385                 390                 395                 400 


Thr Gly Asn Ile Arg Thr Leu Ile Phe Pro Val Met Tyr Ile Asn Glu 
                405                 410                 415     


Ser Val Leu Ile Asp Glu Ala Ser Ala Asn Lys Leu Lys His Val Leu 
            420                 425                 430         


Leu Glu Ala Ser Val Val Thr Gly Ile Pro Phe Val Ile Met Ala Ile 
        435                 440                 445             


Gly Ile Val Phe Gly Ile Val Phe Ser Val Leu Val Cys Arg Ala Gln 
    450                 455                 460                 


Gly Ala Arg Glu Glu Ser Thr Glu Glu Glu Arg Ser Pro Leu Ile Arg 
465                 470                 475                 480 


Thr 
    


<210>  64
<211>  483
<212>  PRT
<213>  Xenopus tropicalis

<400>  64

Met Val Lys Trp Ala Val Phe Gly Thr Ala Ala Val Ser Val Thr Leu 
1               5                   10                  15      


Leu Ile Val Ser Ile Val Leu Leu Leu Thr His Thr Phe Met Asp Ile 
            20                  25                  30          


Val Glu Gly Gln Val Lys Gln Ala Ile Val Leu Lys Asn Glu Ser Glu 
        35                  40                  45              


Val Phe Glu Asp Trp Ala Asn Pro Pro Pro Pro Val Tyr Met Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Leu Glu Val Leu Ser Gly Glu Lys 
65                  70                  75                  80  


Pro Phe Val Asp Glu Ile Gly Pro Tyr Thr Tyr Arg Glu Tyr Arg Pro 
                85                  90                  95      


Arg Glu Asn Ile Thr Phe Ser Val Asn Gly Thr Glu Val Ser Ala Val 
            100                 105                 110         


Thr Pro Lys Thr Tyr Val Phe Glu Pro Glu Lys Ser Ile Gly Asp Pro 
        115                 120                 125             


Lys Val Asp Leu Ile Arg Thr Val Asn Ile Pro Leu Val Thr Ile Leu 
    130                 135                 140                 


Glu Met Thr Lys Asp Ser Ser Leu Leu Arg Pro Phe Ile Ile Ala Ala 
145                 150                 155                 160 


Leu Lys Thr Tyr Lys Glu Gly Met Phe Val Thr Arg Thr Val Asp Glu 
                165                 170                 175     


Leu Leu Trp Gly Tyr Lys Asp Ala Val Leu Ser Ile Leu His Pro Phe 
            180                 185                 190         


Lys Lys Asn Ile Ser Asp Thr Phe Gly Leu Phe Tyr Lys Met Asn Thr 
        195                 200                 205             


Thr Asp Asp Gly Glu Tyr Ile Phe Leu Ser Gly Glu Lys Asp Tyr Leu 
    210                 215                 220                 


Glu Phe Thr Gln Ile Ala Glu Trp Lys Gly Gln Lys Ala Leu Asn Trp 
225                 230                 235                 240 


Trp Thr Thr Glu Thr Cys Asn Met Ile Asn Gly Thr Asp Gly Thr Ser 
                245                 250                 255     


Phe His Pro Leu Leu Asn Lys Asp Asp Thr Ile Tyr Met Phe Ser Ser 
            260                 265                 270         


Asp Leu Cys Arg Ser Ile Tyr Ala Val Tyr Glu Ser Ser Glu Asn Ile 
        275                 280                 285             


Lys Asp Ile Ser Val Phe Arg Phe Ser Pro Pro Ala Ser Val Phe Ala 
    290                 295                 300                 


Asn Val Ser Val Asn Pro Gln Asn Lys Gly Phe Cys Val Pro Glu Gly 
305                 310                 315                 320 


Asn Cys Leu Pro Ser Gly Leu Leu Asn Val Ser Ile Cys Lys Glu Gly 
                325                 330                 335     


Ala Pro Ile Val Leu Ser Ser Pro His Phe Tyr Gln Ala Asp Glu Asn 
            340                 345                 350         


Val Ile Asn Ser Ile Arg Gly Met Lys Pro Val Lys Glu His His Met 
        355                 360                 365             


Thr Phe Leu Asp Leu Asn Pro Leu Thr Gly Thr Leu Ile Gln Ala Ala 
    370                 375                 380                 


Lys Arg Ile Gln Val Asn Val Tyr Val Arg Lys Ile Asn Val Tyr Leu 
385                 390                 395                 400 


Ile Thr Gln Asp Ile Gln Thr Leu Phe Phe Pro Val Met His Leu Asn 
                405                 410                 415     


Glu Ser Val Leu Ile Asp Asp Lys Ser Ala Gly Arg Leu Arg Ser Ile 
            420                 425                 430         


Leu Phe Gln Gly Arg Val Val Ala Asn Ile Pro Phe Ile Ile Met Gly 
        435                 440                 445             


Leu Gly Ile Ile Leu Ala Phe Leu Phe Thr Thr Leu Ser Cys Leu Gln 
    450                 455                 460                 


Lys Arg Ser Arg Asp Glu Gly Thr Glu Glu Glu Arg Gly Pro Leu Ile 
465                 470                 475                 480 


Arg Ala Ser 
            


<210>  65
<211>  551
<212>  PRT
<213>  Drosophila melanogaster

<400>  65

Met Gln Leu Asp Asp Ile Leu His Ile Asn Asn Cys Lys Ala Asp Cys 
1               5                   10                  15      


Ser Ser Leu Ser Thr Thr Pro Asn Pro Lys Thr Asp Leu Val Asn Met 
            20                  25                  30          


Asn Gly Pro Lys His Lys Phe Cys Thr Lys Leu Ser Ser Thr Tyr Leu 
        35                  40                  45              


Arg Lys Trp Trp Ile Thr Ile Val Val Ala Ala Ala Leu Ile Ile Gly 
    50                  55                  60                  


Gly Ile Val Val Ala Cys Glu Phe Thr Val Leu Ile Asp Ala Val Val 
65                  70                  75                  80  


Asp Arg Met Val Ala Leu Arg Pro Gly Ala Lys Thr Phe Gly Trp Trp 
                85                  90                  95      


Ala Lys Pro Pro Val Glu Pro Arg Ile Ser Leu Tyr Ile Tyr Asn Val 
            100                 105                 110         


Thr Asn Ala Asp Asp Phe Leu Ser Asn Gly Ser Lys Ala Ile Val Asp 
        115                 120                 125             


Glu Val Gly Pro Tyr Val Tyr Ser Glu Thr Trp Glu Lys Val Asn Ile 
    130                 135                 140                 


Val Glu Asn Asp Asn Gly Thr Leu Ser Tyr Asn Leu Arg Lys Ile Tyr 
145                 150                 155                 160 


Ser Phe Arg Glu Asp Leu Ser Val Gly Pro Glu Asp Asp Val Val Ile 
                165                 170                 175     


Val Pro Asn Ile Pro Met Leu Ser Ala Thr Ser Gln Ser Lys His Ala 
            180                 185                 190         


Ala Arg Phe Leu Arg Leu Ala Met Ala Ser Ile Met Asp Ile Leu Lys 
        195                 200                 205             


Ile Lys Pro Phe Val Gln Val Ser Val Gly Gln Leu Leu Trp Gly Tyr 
    210                 215                 220                 


Glu Asp Pro Leu Leu Lys Leu Ala Lys Asp Val Val Pro Lys Glu Gln 
225                 230                 235                 240 


Lys Leu Pro Tyr Glu Glu Phe Gly Leu Leu Tyr Gly Lys Asn Gly Thr 
                245                 250                 255     


Ser Ser Asp Arg Val Thr Val Asn Thr Gly Val Asp Asp Ile Arg Arg 
            260                 265                 270         


Tyr Gly Ile Ile Asp Asn Phe Asn Gly Arg Thr His Leu Pro His Trp 
        275                 280                 285             


Thr Thr Asp Ala Cys Asn Thr Leu Ala Gly Thr Asp Gly Ser Ile Phe 
    290                 295                 300                 


Pro Pro His Ile Asp His Asp Arg Ile Leu His Val Tyr Asp Lys Asp 
305                 310                 315                 320 


Leu Cys Arg Leu Leu Pro Leu Val Phe Glu Lys Glu Val Met Thr Ser 
                325                 330                 335     


Asn Glu Val Pro Gly Tyr Arg Phe Thr Pro Pro Glu Trp Val Phe Ala 
            340                 345                 350         


Asp Val Asp Ser His Pro Asp Asn Met Cys Phe Cys Pro Ala Gly Lys 
        355                 360                 365             


Pro Ser Cys Ser Pro Asn Gly Leu Phe Asn Val Ser Leu Cys Gln Tyr 
    370                 375                 380                 


Asp Ser Pro Ile Met Leu Ser Phe Pro His Phe Tyr Leu Ala Asp Glu 
385                 390                 395                 400 


Ser Leu Arg Thr Gln Val Glu Gly Ile Ser Pro Pro Met Lys Glu Lys 
                405                 410                 415     


His Gln Phe Phe Phe Asp Val Gln Pro Lys Met Gly Thr Thr Leu Arg 
            420                 425                 430         


Val Arg Ala Arg Ile Gln Ile Asn Leu Ala Val Ser Gln Val Phe Asp 
        435                 440                 445             


Ile Lys Gln Val Ala Asn Phe Pro Asp Ile Ile Phe Pro Ile Leu Trp 
    450                 455                 460                 


Phe Glu Glu Gly Ile Asp Asn Leu Pro Asp Glu Val Thr Asp Leu Met 
465                 470                 475                 480 


Arg Phe Ala Glu Gln Val Pro Pro Lys Ile Arg Val Ala Leu Ile Val 
                485                 490                 495     


Gly Leu Cys Ala Leu Gly Val Ile Leu Leu Leu Leu Ser Thr Phe Cys 
            500                 505                 510         


Leu Ile Arg Asn Ser His Arg Gln Ser Thr Leu His Leu Glu Gly Ser 
        515                 520                 525             


Asn Tyr Leu Ala Thr Ala Gln Val Asp Met Asn Lys Lys Gln Asn Lys 
    530                 535                 540                 


Asp Asn Gln Pro Ala Arg Tyr 
545                 550     


<210>  66
<211>  522
<212>  PRT
<213>  Anopheles gambiae str. PEST

<400>  66

Met Tyr Gly Arg Ser Asn Arg Leu Cys Ala Lys Leu Ser Ser Ala Phe 
1               5                   10                  15      


Leu Arg Lys Trp Trp Phe Val Ile Ala Phe Ala Leu Ser Leu Leu Val 
            20                  25                  30          


Leu Gly Ala Leu Val Thr Phe Gly Phe Thr Ala Phe Ile Arg Thr Ile 
        35                  40                  45              


Ile Asp His Gln Val Ala Leu Arg Val Gly Gly Gln Ser Phe Gly Trp 
    50                  55                  60                  


Trp Ser Arg Pro Pro Val Glu Pro Ile Ile Arg Ile Phe Val Tyr Asn 
65                  70                  75                  80  


Val Thr Asn Ala Asp Glu Phe Leu Asn Asn Gly Thr Lys Pro Ile Leu 
                85                  90                  95      


Asp Glu Leu Gly Pro Tyr Val Tyr Val Gln Thr Trp Glu Lys Val Asn 
            100                 105                 110         


Ile Lys Glu Asn Pro Asn Gly Thr Ile Ser Tyr Asn Gln Lys Arg Val 
        115                 120                 125             


Tyr Ile Phe Asn Glu Asp Leu Ser Gly Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Ile Val Pro Asn Ile Pro Met Leu Ser Ala Thr Ser Gln Ser Lys His 
145                 150                 155                 160 


Ala Ala Arg Phe Leu Arg Leu Ala Met Ala Ser Ile Met Asp Ile Leu 
                165                 170                 175     


Lys Ile Lys Pro Phe Val Glu Val Ser Val Gly Gln Leu Leu Trp Gly 
            180                 185                 190         


Tyr Glu Asp Pro Leu Leu Lys Leu Ala Lys Asp Val Val Pro Lys Glu 
        195                 200                 205             


Gln Lys Leu Pro Tyr Glu Glu Phe Gly Leu Met Tyr Gly Lys Asn Ser 
    210                 215                 220                 


Thr Ser Lys Asp Thr Val Thr Val Trp Thr Gly Val Asp Asp Ile Thr 
225                 230                 235                 240 


Gln Tyr Gly Ile Ile Asp Lys Tyr Asn Gly Arg Ser His Gln Thr His 
                245                 250                 255     


Trp Leu Ser Glu Gln Cys Asn Arg Leu Asn Gly Thr Asp Gly Ser Ile 
            260                 265                 270         


Phe Pro Pro Arg Ile Thr Lys Asn Ser Thr Leu His Val Tyr Glu Lys 
        275                 280                 285             


Asp Leu Cys Arg Leu Leu Pro Leu Ser Phe Glu Lys Glu Val Thr Val 
    290                 295                 300                 


Arg Gly Gly Val Lys Gly Tyr Arg Phe Thr Pro Ser Pro Asp Val Phe 
305                 310                 315                 320 


Ala Ser Val Asp Lys Asn Pro Asn Asn Met Cys Tyr Cys Pro Ala Gly 
                325                 330                 335     


Pro Pro Cys Ala Pro His Gly Leu Phe Asn Val Ser Leu Cys Gln Tyr 
            340                 345                 350         


Asp Ser Pro Ile Leu Leu Ser Phe Pro His Phe Tyr Met Ala Asp Gln 
        355                 360                 365             


Thr Leu Arg Thr Ala Val Glu Gly Ile Ser Pro Pro Glu Lys Asp Lys 
    370                 375                 380                 


His Gln Leu Phe Ile Asp Val Gln Pro Asp Met Gly Thr Ala Leu Arg 
385                 390                 395                 400 


Ala Arg Ala Arg Ile Gln Ile Asn Leu Ala Val Ser Gln Val Val Asp 
                405                 410                 415     


Ile Lys Gln Val Ala Asn Phe Pro Asp Ile Val Phe Pro Ile Leu Trp 
            420                 425                 430         


Phe Glu Glu Gly Ile Asp Ser Leu Pro Asp Glu Ile Leu Asp Leu Met 
        435                 440                 445             


Lys Val Ala Thr Asn Ile Pro Pro Arg Ala Lys Phe Ile Leu Thr Ile 
    450                 455                 460                 


Ala Leu Phe Gly Leu Gly Gly Phe Leu Phe Val Val Ala Val Ile Cys 
465                 470                 475                 480 


Leu Val Arg Lys Ser His Arg Gln Ser Thr Leu His Leu Glu Gly Ser 
                485                 490                 495     


Asn Tyr Leu Ala Thr Ala Ser Val Asp Gln Ala Lys Lys Lys Ala Lys 
            500                 505                 510         


Met Asp Asn Gly Met Ser Ser Lys Ser Asn 
        515                 520         


<210>  67
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Val Arg Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  68
<211>  338
<212>  PRT
<213>  Pan troglodytes

<400>  68

Met Val Arg Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  69
<211>  338
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  69

Met Gly Ala Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  70
<211>  341
<212>  PRT
<213>  Mus musculus

<400>  70

Met Val Gly Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ala Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Leu Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Ser Lys Tyr Ala Lys Thr Glu Pro Asp Ser Met Gln Val Ile 
305                 310                 315                 320 


Glu Phe Leu His Ile Asp Leu Lys Ser Ile Arg His Pro Leu Lys Val 
                325                 330                 335     


Asn Pro Ile Gln Lys 
            340     


<210>  71
<211>  337
<212>  PRT
<213>  Xenopus laevis

<400>  71

Met Val Gly Arg Ser Gln Ser Asp Arg Asn Gln Leu Pro Leu Phe Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Gly 
            20                  25                  30          


Asp Phe Asn Arg Ser Thr Asp Asn Met Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Phe Val Glu Asp Lys Ser Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Val Asp Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg Ser Pro Phe Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Ser Asp Glu Gly Pro Tyr Ile Cys Ser 
            100                 105                 110         


Val Gln Thr Asn Gln His Thr Lys Thr Met Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ala Asp Ile Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Met Cys Ile Ala Tyr Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Met Ile Thr Trp Arg His Leu Thr Pro Thr Ala Arg Asp Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Phe Leu Glu Ile Gln Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Arg Tyr Glu Cys Lys Ala Ala Asn Glu Val Ala Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Arg Val Thr Val Asn Tyr Pro Pro Ile Ile Thr Glu Ser 
    210                 215                 220                 


Asn Ser Asn Glu Ala Thr Thr Gly Lys Gln Ala Ile Leu Arg Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Lys Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Gln Gly Leu Glu Ile Arg Asn Thr Gly Ser Arg 
            260                 265                 270         


Ser Val Leu Met Val Ala Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Ile Thr Asn Thr Ser Leu Tyr 
    290                 295                 300                 


Leu Tyr Ile Gly Pro Gly Thr Pro Ile Asp Asn Ala Thr Ser Leu Ala 
305                 310                 315                 320 


Ala Ser Leu Trp Leu Met Ala Asn Ile Leu Leu Cys Leu Phe Cys Thr 
                325                 330                 335     


Cys 
    


<210>  72
<211>  333
<212>  PRT
<213>  Danio rerio

<400>  72

Met Ser Cys Leu Trp Ile His Ser Val Phe Ile Pro Gly Phe Phe Leu 
1               5                   10                  15      


Leu Phe Gly Phe Glu Gly Phe Pro Val Ile Ser Val Glu Ser Gln Arg 
            20                  25                  30          


Ser Thr Asp Asn Ile Thr Ile Arg Gln Gly Asp Thr Thr Val Ile Arg 
        35                  40                  45              


Cys Tyr Val Asp Asp Lys Val Ser Lys Val Ala Trp Leu Asn Arg Ser 
    50                  55                  60                  


Asn Ile Ile Phe Ala Gly Glu Asp Lys Trp Ser Leu Asp Pro Arg Val 
65                  70                  75                  80  


Glu Leu Val Thr Gln Gly Gln Leu Glu Tyr Ser Leu Arg Ile Gln Lys 
                85                  90                  95      


Val Asp Val Phe Asp Glu Gly Pro Tyr Thr Cys Ser Ile Gln Thr Lys 
            100                 105                 110         


Gln Gln Ser Lys Thr Ser Gln Val Tyr Leu Ile Val Gln Val Pro Ala 
        115                 120                 125             


Ile Ile Tyr Lys Val Ser Glu Asp Ile Thr Val Asn Glu Gly Ser Asn 
    130                 135                 140                 


Val Ala Leu Thr Cys Leu Ala Asn Gly Arg Pro Asp Pro Ala Ile Thr 
145                 150                 155                 160 


Trp Arg Leu Leu Asn Pro Ser Ala Glu Ala Leu Asp Val Gly Glu Tyr 
                165                 170                 175     


Leu Glu Ile Ser Gly Val Val Arg Ser Gln Ala Gly Arg Tyr Glu Cys 
            180                 185                 190         


Lys Ala Ser Asn Asp Val Ser Thr Pro Asp Val Lys Tyr Val Asn Val 
        195                 200                 205             


Val Val Asn Tyr Pro Pro Tyr Ile Lys Asp Val Arg Ser Ser Glu Thr 
    210                 215                 220                 


Ala Val Gly Gln Ala Gly Val Leu His Cys Glu Ala Ser Ala Val Pro 
225                 230                 235                 240 


Gln Pro Glu Phe Glu Trp Tyr Arg Asp Glu Arg Arg Leu Ser Ser Ser 
                245                 250                 255     


Gln Ser Leu Thr Ile Gln Val Ser Gly Ser Arg Thr Val Leu Val Val 
            260                 265                 270         


Ala Asn Val Thr Glu Glu Asp Tyr Gly Asn Tyr Thr Cys Val Ala Thr 
        275                 280                 285             


Asn Arg Leu Gly Val His Asn Ala Ser Val Phe Leu Tyr Lys Pro Gly 
    290                 295                 300                 


Met Gly Arg Asp Ile Asn Ser Ala Gly Cys Ile Cys Gln Ser Leu Trp 
305                 310                 315                 320 


Leu Leu Leu Leu Cys Val Ser Ser Ala Leu Leu Gln Cys 
                325                 330             


<210>  73
<211>  197
<212>  PRT
<213>  Mus musculus

<400>  73

Met Ser Gly Ser Ser Arg Arg Leu Leu Trp Ala Ala Thr Cys Leu Ala 
1               5                   10                  15      


Val Leu Cys Val Ser Ala Ala Gln Pro Asn Ile Thr Thr Leu Ala Pro 
            20                  25                  30          


Asn Val Thr Glu Val Pro Thr Thr Thr Thr Lys Val Val Pro Thr Thr 
        35                  40                  45              


Gln Met Pro Thr Val Leu Pro Glu Thr Cys Ala Ser Phe Asn Ser Cys 
    50                  55                  60                  


Val Ser Cys Val Asn Ala Thr Phe Thr Asn Asn Ile Thr Cys Phe Trp 
65                  70                  75                  80  


Leu His Cys Gln Glu Ala Asn Lys Thr Tyr Cys Ala Asn Glu Pro Leu 
                85                  90                  95      


Ser Asn Cys Ser Gln Val Asn Arg Thr Asp Leu Cys Ser Val Ile Pro 
            100                 105                 110         


Pro Thr Thr Pro Val Pro Thr Asn Ser Thr Ala Lys Pro Thr Thr Arg 
        115                 120                 125             


Pro Ser Ser Pro Thr Pro Thr Pro Ser Val Val Thr Ser Ala Gly Thr 
    130                 135                 140                 


Thr Asn Thr Thr Leu Thr Pro Thr Ser Gln Pro Glu Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val 
                165                 170                 175     


Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg 
            180                 185                 190         


Asn Tyr His Thr Leu 
        195         


<210>  74
<211>  197
<212>  PRT
<213>  Macaca mulatta

<400>  74

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Val Thr Cys Leu Ala 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Glu Glu Asn Pro Thr Pro His Thr Asn 
            20                  25                  30          


Val Thr Ser Leu Ala Pro Thr Ser Asn Ile Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Ala Ser Thr Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Pro 
            100                 105                 110         


Thr Ala Thr Leu Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Thr Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val 
                165                 170                 175     


Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg 
            180                 185                 190         


Asn Tyr His Thr Leu 
        195         


<210>  75
<211>  194
<212>  PRT
<213>  Sus scrofa

<400>  75

Met Leu Gly Leu Ser Arg Gln Leu Leu Trp Ala Val Gly Cys Leu Ala 
1               5                   10                  15      


Ala Leu Cys Val Leu Thr Ala Ala Lys Asn Ser Thr Ile Leu Pro Pro 
            20                  25                  30          


Ser Thr Thr Thr Pro Trp Leu Ser Pro Pro Thr Thr Gln Thr Thr Ser 
        35                  40                  45              


Ala Pro Pro Lys Thr Leu Pro Thr Pro Ala Pro Glu Ile Cys Glu Asn 
    50                  55                  60                  


Arg Asn Ser Cys Ile Ser Cys Phe Asp Ala Asn Asn Thr Cys Phe Trp 
65                  70                  75                  80  


Ile Glu Cys Lys Gly Lys Ser Tyr Cys Ser Asp Asn Ser Thr Val Ser 
                85                  90                  95      


Asp Cys His Val Val Asn Gly Thr Asp Phe Cys Ser Gly Pro Thr Val 
            100                 105                 110         


Thr Pro Leu Pro Thr Asn Ser Thr Ala Lys Thr Thr Thr Leu Pro Ser 
        115                 120                 125             


Pro Ser Ser Ala Ser Thr Thr Ala Thr Thr Ser Gly Thr Thr Asn Thr 
    130                 135                 140                 


Thr Leu Ala Pro Thr Thr Gln Pro Met Arg Lys Ser Thr Phe Asp Ala 
145                 150                 155                 160 


Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala Val 
                165                 170                 175     


Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His 
            180                 185                 190         


Thr Leu 
        


<210>  76
<211>  198
<212>  PRT
<213>  Bos taurus

<400>  76

Met Ser Gly Leu Ser Arg Pro Leu Leu Leu Ala Val Gly Cys Leu Ala 
1               5                   10                  15      


Ala Leu Cys Val Ile Thr Ala Ala Gly Asn Thr Thr Leu Ala Pro Asn 
            20                  25                  30          


Val Thr Thr Ala Ser Ser Pro Pro Pro Thr Thr Thr Thr Val Pro Val 
        35                  40                  45              


Ser Pro Thr Thr Leu Ser Pro Leu Pro Val Thr Thr Pro Ala Pro Asp 
    50                  55                  60                  


Ile Cys Gly Ser Arg Asn Ser Cys Val Ser Cys Val Asp Gly Asn Ala 
65                  70                  75                  80  


Thr Cys Phe Trp Ile Glu Cys Lys Gly Lys Ser Tyr Cys Ser Asp Asn 
                85                  90                  95      


Ser Thr Ala Gly Asp Cys Lys Val Val Asn Thr Thr Gly Phe Cys Ser 
            100                 105                 110         


Val Pro Thr Thr Thr Pro Thr Pro Thr Asn Ser Thr Ala Lys Thr Thr 
        115                 120                 125             


Thr Leu Pro Ser Thr Thr Thr Thr Ser Thr Thr Ala Thr Thr Ser Gly 
    130                 135                 140                 


Thr Thr Asn Thr Thr Leu Ser Pro Thr Ile Gln Pro Thr Arg Lys Ser 
145                 150                 155                 160 


Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly 
                165                 170                 175     


Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu 
            180                 185                 190         


Arg Asn Tyr His Thr Leu 
        195             


<210>  77
<211>  198
<212>  PRT
<213>  Ovis aries

<400>  77

Met Ser Gly Leu Ser Arg Pro Leu Leu Leu Ala Val Gly Tyr Leu Ala 
1               5                   10                  15      


Ala Leu Cys Val Ile Thr Ala Ala Arg Asn Thr Thr Val Thr Pro Asn 
            20                  25                  30          


Val Thr Thr Pro Ser Ser Pro Pro Pro Thr Thr Ala Thr Val Pro Val 
        35                  40                  45              


Ser Pro Thr Thr Leu Thr Pro Pro Pro Val Thr Thr Pro Ala Pro Asp 
    50                  55                  60                  


Ile Cys Gly Ser Arg Asn Ser Cys Ile Ser Cys Val Asp Gly Asn Ala 
65                  70                  75                  80  


Thr Cys Phe Trp Ile Glu Cys Lys Gly Lys Ser Tyr Cys Ser Asp Asn 
                85                  90                  95      


Ser Thr Val Ser Asp Cys Lys Val Val Asn Thr Thr Gly Phe Cys Ala 
            100                 105                 110         


Val Pro Thr Thr Thr Pro Thr Pro Thr Asn Ser Thr Ala Lys Thr Thr 
        115                 120                 125             


Thr Leu Pro Ser Thr Thr Thr Thr Ser Thr Thr Ala Thr Thr Ser Gly 
    130                 135                 140                 


Thr Ala Asn Thr Thr Leu Thr Pro Thr Ile Gln Pro Met Arg Lys Ser 
145                 150                 155                 160 


Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly 
                165                 170                 175     


Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu 
            180                 185                 190         


Arg Asn Tyr His Thr Leu 
        195             


<210>  78
<211>  198
<212>  PRT
<213>  Canis lupus familiaris

<400>  78

Met Ser Gly Leu Ser Arg Gln Leu Cys Trp Ala Ala Ala Cys Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ala Leu Thr Ala Ala Gln Ser Phe Ser Ser Asp Pro Asn 
            20                  25                  30          


Gly Thr Thr Thr Thr Thr Gln Ala Thr Thr Asp Ala Ala Thr Thr Arg 
        35                  40                  45              


Val Thr Thr Ala Ala Pro Ala Thr Thr Pro Ala Pro Asp Pro Cys Asp 
    50                  55                  60                  


Asn Arg Asn Ser Cys Val Ser Cys Val Asn Thr Ser Val Asp Ala Thr 
65                  70                  75                  80  


Ala Cys Ser Trp Ile Glu Cys Lys Glu Lys Ser Tyr Cys Ser His Asn 
                85                  90                  95      


Thr Thr Val Ser Asp Cys Gln Val Val Asn Ser Thr Gln Leu Cys Ser 
            100                 105                 110         


Ala Pro Glu Pro Thr Met Met Pro Thr Asn Ser Thr Ala Lys Thr Thr 
        115                 120                 125             


Thr Gln Pro Ser Ser Ser Thr Ala Thr Thr Thr Ala Thr Thr Ser Gly 
    130                 135                 140                 


Thr Thr Asn Ile Thr Leu Ser Pro Thr Ser Gln Pro Gly Arg Lys Ser 
145                 150                 155                 160 


Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Ile Leu Gly 
                165                 170                 175     


Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu 
            180                 185                 190         


Arg Asn Tyr His Thr Leu 
        195             


<210>  79
<211>  195
<212>  PRT
<213>  Rattus norvegicus

<400>  79

Met Ser Gly Ala Ser Arg Gly Leu Phe Trp Ala Ala Thr Cys Leu Ala 
1               5                   10                  15      


Ala Leu Cys Leu Ser Ala Ala Gln Ser Asn Ser Ser Ala Ser Pro Asn 
            20                  25                  30          


Val Thr Asp Pro Pro Thr Thr Thr Ser Lys Val Val Pro Thr Thr Leu 
        35                  40                  45              


Thr Thr Thr Lys Pro Pro Glu Thr Cys Glu Ser Phe Asn Ser Cys Val 
    50                  55                  60                  


Ser Cys Val Asn Ala Thr Leu Thr Asn Asn Ile Thr Cys Val Trp Leu 
65                  70                  75                  80  


Asp Cys His Glu Ala Asn Lys Thr Tyr Cys Ser Ser Glu Leu Val Ser 
                85                  90                  95      


Asn Cys Thr Gln Lys Thr Ser Thr Asp Ser Cys Ser Val Ile Pro Thr 
            100                 105                 110         


Thr Pro Val Pro Thr Asn Ser Thr Ala Lys Pro Thr Thr Arg Pro Ser 
        115                 120                 125             


Ser Pro Thr Pro Thr Pro Ser Val Val Thr Ser Ala Gly Ala Thr Asn 
    130                 135                 140                 


Thr Thr Val Thr Pro Thr Ser Gln Pro Glu Arg Lys Ser Thr Phe Asp 
145                 150                 155                 160 


Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala 
                165                 170                 175     


Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr 
            180                 185                 190         


His Thr Leu 
        195 


<210>  80
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Ser Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  81
<211>  354
<212>  PRT
<213>  Pan troglodytes

<400>  81

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Ala Ser His Gly Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Ser Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Ala Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Arg Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  82
<211>  335
<212>  PRT
<213>  Bos taurus

<400>  82

Met Arg Leu Ala Val Phe Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Ala Thr Glu Ser Thr Pro Ser 
        35                  40                  45              


Pro Gly Thr Thr Ser His Arg Thr Thr Lys Ser His Arg Thr Thr Thr 
    50                  55                  60                  


Trp Arg Ile Ser Thr Thr Thr His Thr Thr Asn Thr Thr Gly Thr Thr 
65                  70                  75                  80  


Ser Ser Glu Ser Pro Thr Ala Thr His Ser Pro Ala Thr Thr Thr Ser 
                85                  90                  95      


His Gln Asn Thr Thr Val His Pro Thr Ser Asn Ile Thr Ala Thr Ser 
            100                 105                 110         


Pro Gly Pro Ser Thr Arg Ser Pro His Pro Glu Pro Pro Pro Ser Pro 
        115                 120                 125             


Ser Pro Ser Pro Gly Ser Lys Glu Ala Ile Gly Asp Tyr Thr Trp Ser 
    130                 135                 140                 


Asn Gly Ser Gln Pro Cys Val Arg Leu Gln Ala Gln Ile Gln Ile Arg 
145                 150                 155                 160 


Val Leu Tyr Pro Thr Gln Gly Gly Gly Glu Ala Trp Gly Ile Ser Val 
                165                 170                 175     


Leu Asn Pro Asn Arg Thr Lys Ala Gln Gly Gly Cys Glu Gly Thr His 
            180                 185                 190         


Ser His Leu Leu Leu Ser Phe Pro Ser Gly Gln Leu Ser Phe Gly Phe 
        195                 200                 205             


Lys Gln Asp Pro Leu Gln Ser Ala Val Tyr Leu Asn Tyr Met Ala Val 
    210                 215                 220                 


Glu Tyr Asn Val Ser Phe Pro Gln Ala Val Gln Trp Thr Phe Ser Val 
225                 230                 235                 240 


Gln Asn Ser Ser Leu Arg Asp Leu Gln Thr Pro Leu Gly His Ser Phe 
                245                 250                 255     


Ser Cys Arg Asn Ala Ser Ile Ile Val Ser Pro Ala Leu His Leu Asp 
            260                 265                 270         


Leu Leu Ser Leu Lys Leu Gln Ala Ala Gln Leu Ser Pro Ser Gly Ala 
        275                 280                 285             


Phe Gly Pro Ser Phe Ser Cys Pro Asn Asp Lys Ser Ile Leu Leu Pro 
    290                 295                 300                 


Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Thr Leu Val Leu Val 
305                 310                 315                 320 


Thr Phe Cys Ile Ile Arg Arg Arg Pro Pro Thr Tyr Gln Pro Leu 
                325                 330                 335 


<210>  83
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  83

Met Arg Leu Pro Val Cys Leu Ile Leu Leu Gly Pro Leu Ile Ala Gln 
1               5                   10                  15      


Gly Thr Glu Glu Asp Cys Pro His Lys Lys Ala Val Thr Leu Leu Pro 
            20                  25                  30          


Ser Phe Thr Met Thr Pro Thr Ala Thr Glu Ser Thr Ala Ser Pro Thr 
        35                  40                  45              


Thr Ser His Arg Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His 
    50                  55                  60                  


Thr Ser Ser Gly Pro Thr Thr Val Thr His Asn Pro Ala Thr Thr Thr 
65                  70                  75                  80  


Ser His Gly Asn Ala Thr Ile Ser His Ala Thr Val Ser Pro Thr Thr 
                85                  90                  95      


Asn Gly Thr Ala Thr Ser Pro Arg Ser Ser Thr Val Gly Pro His Pro 
            100                 105                 110         


Gly Pro Pro Pro Pro Ser Pro Ser Pro Arg Ser Lys Gly Ala Leu Gly 
        115                 120                 125             


Asn Tyr Thr Trp Ala Asn Gly Ser Gln Pro Cys Val Gln Leu Gln Ala 
    130                 135                 140                 


Gln Ile Gln Ile Arg Ile Leu Tyr Pro Ile Gln Gly Gly Arg Lys Val 
145                 150                 155                 160 


Lys Leu Lys Trp Gly Leu Lys Arg Ala Trp Gly Ile Ser Val Leu Asn 
                165                 170                 175     


Pro Asn Lys Thr Lys Val Gln Gly Gly Cys Asp Gly Thr His Pro His 
            180                 185                 190         


Leu Ser Leu Ser Phe Pro Tyr Gly Gln Leu Thr Phe Gly Phe Lys Gln 
        195                 200                 205             


Asp Leu His Gln Ser Pro Ser Thr Val Tyr Leu Asp Tyr Met Ala Val 
    210                 215                 220                 


Glu Tyr Asn Val Ser Phe Pro Gln Ala Ala Gln Trp Thr Phe Met Ala 
225                 230                 235                 240 


Gln Asn Ser Ser Leu Arg Glu Leu Gln Ala Pro Leu Gly Gln Ser Phe 
                245                 250                 255     


Cys Cys Gly Asn Ala Ser Ile Val Leu Ser Pro Ala Val His Leu Asp 
            260                 265                 270         


Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro Asp Lys Gly His 
        275                 280                 285             


Phe Gly Pro Cys Phe Ser Cys Asn Arg Asp Gln Ser Leu Leu Leu Pro 
    290                 295                 300                 


Leu Ile Ile Gly Leu Val Leu Leu Gly Leu Leu Thr Leu Val Leu Ile 
305                 310                 315                 320 


Ala Phe Cys Ile Thr Arg Arg Arg Gln Ser Thr Tyr Gln Pro Leu 
                325                 330                 335 


<210>  84
<211>  354
<212>  PRT
<213>  Macaca mulatta

<400>  84

Met Arg Leu Ala Val Leu Phe Leu Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Ala Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Thr Ser His Arg Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Arg Asn Ala Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Arg Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Leu Thr Ser Ser Ala His Pro Gly Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Ala Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Met Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Arg Val Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Val Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Val Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  85
<211>  330
<212>  PRT
<213>  Rattus norvegicus

<400>  85

Met Arg Phe Pro Val Cys Leu Thr Leu Leu Val Leu Leu Val Ala Gln 
1               5                   10                  15      


Gly Thr Gly Lys Asp Cys Pro His Lys Lys Ala Ala Thr Leu Leu Pro 
            20                  25                  30          


Ser Phe Thr Glu Thr Pro Thr Thr Thr Gly Ser Thr Ala Ser Pro Thr 
        35                  40                  45              


Thr Thr His Arg Pro Thr Thr Thr Ser His Arg Pro Thr Thr Thr Ser 
    50                  55                  60                  


His Arg Pro Thr Thr Thr Ser His Arg Pro Thr Thr Thr Ser His Arg 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Arg Pro Thr Thr Thr Ser His Gly Asn Ala 
                85                  90                  95      


Thr Val Ser Pro Thr Thr Asn Ser Pro Gly Phe Ser Thr Val Gly Pro 
            100                 105                 110         


His Pro Gly Pro Pro Pro Pro Ser Pro Ser Pro Ser Pro Ser Ser Thr 
        115                 120                 125             


Gly Ala Leu Gly Asn Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys Val 
    130                 135                 140                 


Gln Leu Gln Ala Gln Ile Gln Ile Arg Ile Leu Tyr Leu Thr Gln Gly 
145                 150                 155                 160 


Gly Lys Lys Ala Trp Gly Leu Ser Val Leu Asn Pro Asn Lys Thr Lys 
                165                 170                 175     


Val Gln Gly Gly Cys Asp Ser Ala His Pro His Leu Ala Leu Ser Phe 
            180                 185                 190         


Pro Tyr Gly Gln Leu Thr Phe Gly Phe Lys Gln Asp Arg His Gln Ser 
        195                 200                 205             


His Ser Thr Val Tyr Leu Asn Tyr Met Ala Val Glu Tyr Asn Val Ser 
    210                 215                 220                 


Phe Pro Gln Ala Ala Gln Trp Thr Phe Ser Ala Gln Asn Ser Ser Leu 
225                 230                 235                 240 


Gln Glu Leu Gln Ala Pro Leu Gly Gln Ser Phe Cys Cys Gly Asn Thr 
                245                 250                 255     


Ser Ile Val Leu Ser Pro Ala Ile His Leu Asp Leu Leu Ser Leu Arg 
            260                 265                 270         


Leu Gln Ala Ala Gln Leu Pro Asp Lys Gly His Phe Gly Pro Cys Phe 
        275                 280                 285             


Ser Cys Ala Ser Asp Gln Ser Leu Leu Leu Pro Leu Ile Ile Gly Leu 
    290                 295                 300                 


Val Leu Leu Gly Leu Leu Thr Leu Val Leu Ile Ala Phe Cys Val Thr 
305                 310                 315                 320 


Arg Arg Arg Gln Ser Thr Tyr Gln Pro Leu 
                325                 330 


<210>  86
<211>  329
<212>  PRT
<213>  Canis lupus familiaris

<400>  86

Met Arg Pro Ala Val Phe Phe Leu Gly Ala Leu Val Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Arg Ser Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Ala Thr Glu Ser Thr Gly Ser 
        35                  40                  45              


Pro Gly Thr Thr Ser His Ser Thr Thr Thr Ala Glu Thr Thr Ser His 
    50                  55                  60                  


Ala Pro Asn Thr Thr Thr His Gln Ala Pro Thr Thr Pro Gly His Arg 
65                  70                  75                  80  


Asn Thr Thr Ile His Pro Thr Thr Ser Asn Ser Thr Ser Asn Thr Thr 
                85                  90                  95      


Gly Thr Thr Gly Thr Gly Lys Pro His Thr Ser Thr Ser Tyr Thr Gln 
            100                 105                 110         


Pro Gly Pro Gly Pro Arg Pro Pro Pro Pro Ser Pro Gly Pro Gly Pro 
        115                 120                 125             


Gln Asp Ala Ile Gly Asp Tyr Thr Trp Thr Thr Gly Ser Gln Pro Cys 
    130                 135                 140                 


Ala Arg Leu Gln Ala Arg Ile Gln Ile Gly Val Val Tyr Pro Thr Gln 
145                 150                 155                 160 


Ala Gly Gly Gln Ala Trp Gly Ile Ser Val Leu Asn Pro Asn Ser Thr 
                165                 170                 175     


Lys Pro Trp Gly Asp Cys Asp Gly Ala Arg Pro His Leu Leu Leu Ser 
            180                 185                 190         


Phe Pro Phe Gly Gln Leu Ser Phe Gly Phe Thr Gln Glu Pro Gln Gln 
        195                 200                 205             


Gly Ser Val Tyr Leu Asp Tyr Leu Ala Leu Gln Tyr Asn Val Ser Phe 
    210                 215                 220                 


Pro Gln Ala Ala Gln Trp Thr Phe Ser Gly Gln Asn Ala Ser Leu Arg 
225                 230                 235                 240 


Ala Leu Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Arg Asn Ala Ser 
                245                 250                 255     


Ile Leu Leu Thr Pro Ala Leu Arg Leu Asp Leu Leu His Leu Lys Leu 
            260                 265                 270         


Gln Ala Ala Gln Leu Pro Pro Ser Gly Ala Phe Gly Pro Ser Phe Ser 
        275                 280                 285             


Cys Pro Ser Glu His Phe Asn Leu Leu Pro Leu Ile Val Gly Val Ile 
    290                 295                 300                 


Ser Leu Gly Leu Leu Ala Leu Ala Leu Val Thr Phe Cys Ile Ile Arg 
305                 310                 315                 320 


Arg Arg Pro Pro Thr Tyr Gln Pro Leu 
                325                 


<210>  87
<211>  322
<212>  PRT
<213>  Equus caballus

<400>  87

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Glu Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Ala Thr Glu Ser Thr Ala Ser 
        35                  40                  45              


Pro Gly Thr Thr Ser His Gln Thr Thr Gln Ser His Arg Thr Thr Thr 
    50                  55                  60                  


Thr Gly Thr Thr Ser Asp His Pro Thr Thr Ala Thr His Asn Pro Thr 
65                  70                  75                  80  


Thr Thr Ser His Gly Asn Thr Thr Val His Pro Thr Thr Ser Asn Ser 
                85                  90                  95      


Thr Val Thr Ser Pro Gly Ser Ala Ser Ser Ser Pro His Pro Arg Pro 
            100                 105                 110         


Pro Pro Pro Ser Pro Ser Pro Ser Pro Gly Ser Lys Glu Ala Ile Gly 
        115                 120                 125             


Asp Tyr Ile Trp Thr Asn Gly Ser Gln Pro Cys Val Arg Leu Gln Ala 
    130                 135                 140                 


Gln Ile Gln Ile Arg Val Leu Tyr Pro Thr Leu Gly Gly Gly Lys Ala 
145                 150                 155                 160 


Trp Gly Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Ala Gln Gly Gly 
                165                 170                 175     


Cys Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly Gln Leu Ser 
            180                 185                 190         


Phe Gly Phe Lys Gln Glu Pro Leu Gln Ser Thr Val Tyr Leu Asn Tyr 
        195                 200                 205             


Ile Ala Val Glu Tyr Asn Val Ser Phe Pro Gln Ala Ala Gln Trp Thr 
    210                 215                 220                 


Phe Leu Val Gln Asn Ser Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
225                 230                 235                 240 


Gln Arg Phe Ser Cys Arg Asn Ala Ser Ile Ala Leu Ser Pro Ala Phe 
                245                 250                 255     


His Leu Asp Leu Leu Ser Leu Lys Leu Gln Ala Ala Gln Leu Thr Pro 
            260                 265                 270         


Thr Gly Ala Phe Gly Pro Ser Phe Ser Cys Pro Ser Asp Gln Ser Ile 
        275                 280                 285             


Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Phe Ala Leu 
    290                 295                 300                 


Val Leu Ile Thr Phe Cys Val Ile Arg Arg Arg Pro Pro Thr Tyr Gln 
305                 310                 315                 320 


Ala Leu 
        


<210>  88
<211>  305
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  88

Met Arg Leu Pro Val Leu Phe Leu Ala Leu Leu Gly Leu His Ala Ala 
1               5                   10                  15      


Ser Ser Gly Thr Thr Ser His Arg Thr Thr Lys Asn Pro His Thr Thr 
            20                  25                  30          


Ser His Ser Thr Ala Thr Pro Gly Thr Thr Ser His Arg Pro Thr Thr 
        35                  40                  45              


Ala Thr Pro Thr Thr Gly His Gly Asn Val Thr Val His Pro Thr Thr 
    50                  55                  60                  


Ser Asn Thr Thr Ser Asn Thr Thr Thr Thr Thr Gly Thr Ser Pro Gly 
65                  70                  75                  80  


Phe Ser Thr Ser Thr Pro His Pro Gly Pro Pro Pro Pro Pro Pro Ser 
                85                  90                  95      


Pro Ser Pro Gly Ser Arg Glu Ala Val Gly Asn Tyr Thr Trp Thr Asn 
            100                 105                 110         


Gly Ser Gln Pro Cys Val Gln Leu Gln Ala Gln Ile Gln Ile Arg Val 
        115                 120                 125             


Leu Tyr Pro Thr Gln Gly Gly Gly Gln Ala Trp Gly Met Ser Val Leu 
    130                 135                 140                 


Asn Pro Asn Arg Thr Lys Ala Gln Gly Gly Cys Glu Gly Pro Arg Pro 
145                 150                 155                 160 


His Leu Leu Leu Ser Phe Pro Tyr Gly Gln Leu Ser Phe Gly Phe Lys 
                165                 170                 175     


Gln Asp Pro Gly Gln Gly Gln Ser Ala Val Tyr Leu Ser Tyr Leu Ala 
            180                 185                 190         


Val Glu Tyr Asn Val Ser Phe Pro Gln Ala Ala Arg Trp Thr Phe Ser 
        195                 200                 205             


Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly Gln Ser 
    210                 215                 220                 


Phe Ser Cys Arg Asn Ala Ser Ile Ala Val Ser Pro Ala Leu His Leu 
225                 230                 235                 240 


Asp Leu Leu Ser Leu Arg Val Gln Ala Ala Gln Leu Pro Arg Thr Gly 
                245                 250                 255     


Ile Phe Gly Pro Ser Phe Ser Cys Pro Ala Asp His Pro Ser Ile Leu 
            260                 265                 270         


Val Pro Leu Ile Ile Gly Leu Ile Leu Val Gly Leu Leu Ala Leu Val 
        275                 280                 285             


Leu Val Ala Phe Cys Ile Ala Arg Arg Arg Pro Ser Ala Tyr Gln Ala 
    290                 295                 300                 


Leu 
305 


<210>  89
<211>  291
<212>  PRT
<213>  Sus scrofa

<400>  89

Met Thr Leu Ala Val Leu Phe Leu Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Glu Ser Thr Thr Ser His Arg Thr Thr Thr Pro Arg Thr Thr Thr Thr 
            20                  25                  30          


Gly Thr Thr Ser His Gly Pro Thr Thr Val Thr His Asn Pro Ala Thr 
        35                  40                  45              


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Ser Ser Thr 
    50                  55                  60                  


Ala Thr Ser Pro Gly Ser Ser Thr Arg Pro Pro His Pro Gly Pro Pro 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Pro Ser Pro Gly Ser Gln Glu Ala Ile Gly Asp 
                85                  90                  95      


Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys Val Gln Leu Gln Ala Gln 
            100                 105                 110         


Ile Gln Ile Arg Val Leu Tyr Pro Thr Gln Gly Gly Gly Glu Ala Trp 
        115                 120                 125             


Gly Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Ala Leu Gly Gly Cys 
    130                 135                 140                 


Glu Gly Ala His Pro His Val Arg Leu Ser Phe Pro Tyr Gly Gln Leu 
145                 150                 155                 160 


Thr Phe Gly Phe Lys Gln Gln Pro Gln Glu Ser Thr Val Tyr Leu Asn 
                165                 170                 175     


Tyr Met Ala Val Glu Tyr Asn Val Ser Phe Pro Arg Ala Ala Gln Trp 
            180                 185                 190         


Thr Phe Ser Val Gln Asn Ser Ser Leu Arg Asp Leu Gln Thr Pro Val 
        195                 200                 205             


Gly Arg Ser Tyr Ser Cys Arg Asn Ala Ser Ile Ile Leu Ser Thr Ala 
    210                 215                 220                 


Phe His Leu Asp Leu Leu Ser Leu Lys Leu Gln Ala Ala Gln Leu Pro 
225                 230                 235                 240 


Pro Thr Gly Asn Phe Gly Pro Ser Phe Ser Cys Pro Ser Asp Gln Thr 
                245                 250                 255     


Ile Leu Leu Pro Leu Ile Ile Gly Leu Ile Phe Leu Gly Leu Leu Ile 
            260                 265                 270         


Leu Val Leu Val Thr Phe Cys Ile Ile Arg Arg Arg Pro Pro Ala Tyr 
        275                 280                 285             


Gln Pro Leu 
    290     


<210>  90
<211>  354
<212>  PRT
<213>  Papio anubis

<400>  90

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Ala Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Thr Ser His Arg Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Asn Thr Thr Ser His Arg Asn Ala Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Arg Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Leu Thr Ser Ser Ala His Pro Gly Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Ala Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Met Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Arg Val Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Val Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Val Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  91
<211>  323
<212>  PRT
<213>  Monodelphis domestica

<400>  91

Met Arg Leu Ser Leu Leu Leu Ser Gly Ile Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Glu Gln Gly Ala Gly Asp Lys Cys Pro Gln Glu Lys Ser Val Thr Leu 
            20                  25                  30          


Val Pro Ser Phe Thr Val Thr Thr Ile Ala Thr Glu Arg Ser Thr Thr 
        35                  40                  45              


Ser Pro Glu Thr Thr Thr Ser Ser Gly Ser Thr Ala Thr Thr Tyr Arg 
    50                  55                  60                  


Thr Ser Thr Ala Ala Thr Thr Pro His Ser Asn Ser Thr Ala Thr Ser 
65                  70                  75                  80  


Tyr Ser Thr Thr Ser Glu Gly Thr Ala Val Thr His Gly Thr Thr Thr 
                85                  90                  95      


Ser Pro Arg Asn Thr Ser Thr Thr Ser Thr Ser Gln Ser Val Pro Val 
            100                 105                 110         


Pro Pro Ser Pro Gln Pro Thr Ser Ser Pro Ser Gly Ala Val Gly Asp 
        115                 120                 125             


Tyr Ile Gly Ala Asn Gly Ser Gln Leu Cys Val His Leu Arg Ala Gln 
    130                 135                 140                 


Ile Gln Met Arg Val Leu Tyr Gln Ala Ser Gly Gly Gly Lys Leu Trp 
145                 150                 155                 160 


Gly Ile Phe Val Leu Asn Pro Asn Arg Thr Met Ala Gln Gly Asn Cys 
                165                 170                 175     


Glu Ala Asn His Ser Ser Leu Ile Leu Ser Phe Pro Asn Gly Lys Leu 
            180                 185                 190         


Ile Phe Gly Phe Lys Gln Asp Ser Ile Lys Lys Ile Val Tyr Leu Ser 
        195                 200                 205             


His Leu Ala Thr Glu Phe Asn Val Ser Phe Pro Ser Ala Thr Arg Trp 
    210                 215                 220                 


Ile Phe Ser Val Glu Asn Ser Ser Leu Gln Asp Leu Gln Thr Pro Leu 
225                 230                 235                 240 


Gly His Ser Phe Ser Cys Arg Asn Arg Ser Ile Ala Leu Ser Pro Asp 
                245                 250                 255     


Ile His Leu Asp Leu Leu Ser Leu Gln Leu Gln Ala Ala Gln Leu Ser 
            260                 265                 270         


Ser Ser Gly Ala Phe Gly Ala Ala Phe Ser Cys Ser Ala Asp Leu Asn 
        275                 280                 285             


Ile Leu Val Pro Leu Val Val Gly Leu Val Leu Leu Thr Leu Leu Ile 
    290                 295                 300                 


Leu Val Leu Ser Ala Phe Cys Ile Ser Arg Arg Arg Pro Pro Ala Tyr 
305                 310                 315                 320 


Gln Pro Leu 
            


<210>  92
<211>  263
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  92

Met Gly Leu Thr Leu Pro Leu Pro Ala Gln Gly Ser Gln Cys Arg Ala 
1               5                   10                  15      


Asn Cys Pro His Lys Lys Ser Ala Thr Leu Val Pro Ser Phe Thr Val 
            20                  25                  30          


Thr Pro Thr Ala Thr Ser Gly Pro Thr Thr Thr Ala His Gln Thr Thr 
        35                  40                  45              


Thr Asp His Gly Thr Thr Thr Ser His Glu Thr Thr Thr Ser Gln Gly 
    50                  55                  60                  


Thr Ser Thr His Gly Thr Ser Thr Pro His Thr Thr Thr Thr Gly His 
65                  70                  75                  80  


Gly Thr Thr Thr Gly His Gln Asn Thr Ser His Ser Thr Thr Thr Ser 
                85                  90                  95      


His Gly Thr Ser Thr Pro His Lys Thr Thr Thr Arg His Pro Thr Thr 
            100                 105                 110         


Ser His Gly Thr Thr Thr Ser His Gly Thr Ser Thr Gly His Trp Thr 
        115                 120                 125             


Ala Arg Pro Thr Ile Arg Pro Gly Pro Pro Pro Pro Pro Pro Ser Pro 
    130                 135                 140                 


Gly Lys Ala Val Gly Asn Tyr Thr Val Phe Asn Gly Ser Gln Pro Cys 
145                 150                 155                 160 


Leu Arg Leu Arg Ala Glu Ile Arg Leu Trp Val Leu Tyr Gln Ala Gln 
                165                 170                 175     


Glu Glu Gly Glu Ala Pro Pro Val Ser Gly Ala Ala Ser Phe Pro Pro 
            180                 185                 190         


Pro Arg Pro Arg Pro Val Ala Gly Glu Gly Asp Gly Glu Arg Ser Arg 
        195                 200                 205             


Val Thr Pro Val Ala Ser Ala Met Thr Val Glu Gly Gly Ser Arg Ala 
    210                 215                 220                 


Gly Phe Ala Met Leu Gly Ala Glu Val Arg Ser Arg Ala Pro Ser Leu 
225                 230                 235                 240 


Gly Arg Ala Gly Lys Thr Arg Leu Arg Ile His Gln Pro Val Val Val 
                245                 250                 255     


Leu Gln His Thr Tyr Tyr Val 
            260             


<210>  93
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Asp Leu Gln Gly Arg Gly Val Pro Ser Ile Asp Arg Leu Arg Val 
1               5                   10                  15      


Leu Leu Met Leu Phe His Thr Met Ala Gln Ile Met Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Asp Ile Ala Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly Arg Cys Gly His Ser Gln Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Ala Leu Lys Met Leu Phe Val Lys Glu Ser His Asn Met 
        115                 120                 125             


Ser Lys Gly Pro Glu Ala Thr Trp Arg Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Met Val Thr Leu Ala Ile Tyr 
                245                 250                 255     


His Val His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  94
<211>  280
<212>  PRT
<213>  Pan troglodytes

<400>  94

Met Asp Leu Arg Gly Arg Ala Val Pro Ser Ile Asp Arg Leu Arg Val 
1               5                   10                  15      


Leu Leu Met Leu Phe His Thr Met Ala Gln Ile Met Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Asp Ile Ala Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly Arg Cys Gly His Ser Glu Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Ala Leu Lys Met Leu Phe Val Lys Glu Ser His Asn Met 
        115                 120                 125             


Ser Lys Gly Pro Glu Ala Thr Trp Arg Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Leu Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Met Val Thr Leu Ala Ile Tyr 
                245                 250                 255     


His Val His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  95
<211>  280
<212>  PRT
<213>  Macaca mulatta

<400>  95

Met Asp Leu Gln Gly Arg Ala Val Pro Ser Val Asp Arg Leu Arg Val 
1               5                   10                  15      


Leu Leu Met Leu Phe His Thr Met Ala Gln Ile Met Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Asp Ile Ala Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly Arg Cys Gly His Ser Glu Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Ala Leu Lys Met Leu Phe Val Lys Glu Ser His Asn Thr 
        115                 120                 125             


Ser Lys Gly Pro Glu Ala Thr Trp Arg Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Met Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Val Val Thr Leu Thr Ile Tyr 
                245                 250                 255     


His Val His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  96
<211>  280
<212>  PRT
<213>  Canis lupus familiaris

<400>  96

Met Asp Leu Arg Gly Arg Ala Phe Pro Ser Val Tyr Arg Leu Arg Val 
1               5                   10                  15      


Leu Leu Met Leu Phe Tyr Thr Met Ala Arg Ile Thr Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Asp Ile Ser Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly His Cys Gly His Asn Glu Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Ala Leu Lys Met Leu Phe Val Lys Glu Ser Arg Asn Ala 
        115                 120                 125             


Ser Lys Gly Pro Glu Ala Thr Trp Arg Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His Arg Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Ser Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Val Val Thr Leu Ala Ile Tyr 
                245                 250                 255     


His Ile His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  97
<211>  280
<212>  PRT
<213>  Bos taurus

<400>  97

Met Asp Leu Arg Arg Arg Ala Leu Leu Gly Val Asp Gly Leu Arg Val 
1               5                   10                  15      


Leu Leu Met Leu Phe His Thr Val Thr Arg Ile Met Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Asp Ile Ser Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly His Cys Gly His Asp Glu Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Ala Leu Lys Met Leu Phe Leu Lys Glu Ser His Asn Thr 
        115                 120                 125             


Pro Lys Gly Pro Glu Ala Thr Trp Lys Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Val Val Thr Leu Val Ile Tyr 
                245                 250                 255     


His Ile His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  98
<211>  280
<212>  PRT
<213>  Mus musculus

<400>  98

Met Asp Leu Arg Val Arg Thr Leu Leu Gly Gly Asp Arg Leu Arg Ile 
1               5                   10                  15      


Leu Leu Met Phe Phe His Val Met Val Gln Thr Val Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Glu Ile Ser Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly His Cys Gly His Asn Glu Ser Glu Leu Glu Val Phe Trp Val Asp 
            100                 105                 110         


His Ala Tyr Thr Leu Arg Met Leu Phe Val Lys Glu Ser His Asn Thr 
        115                 120                 125             


Ser Lys Gly Pro Glu Ala Thr Trp Asn Leu Asn Lys Val His Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Ala Pro Val Lys Val Asn 
145                 150                 155                 160 


Lys Tyr Ile Ala Ser Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Met Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Gln Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Val Ile Thr Leu Val Ile Tyr 
                245                 250                 255     


His Ile His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  99
<211>  280
<212>  PRT
<213>  Rattus norvegicus

<400>  99

Met Asp Leu Arg Gly Arg Ala Leu Leu Gly Gly Asp Arg Leu Arg Ile 
1               5                   10                  15      


Leu Leu Met Phe Phe His Ala Met Ala Gln Thr Val Ala Glu Gln Glu 
            20                  25                  30          


Val Glu Asn Leu Ser Gly Leu Ser Thr Asn Pro Glu Lys Asp Ile Phe 
        35                  40                  45              


Val Val Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ala Ala 
    50                  55                  60                  


Lys Phe Ile Val Pro Tyr Asp Val Trp Ala Ser Asn Tyr Val Asp Leu 
65                  70                  75                  80  


Ile Thr Glu Gln Ala Glu Ile Ser Leu Thr Arg Gly Ala Glu Val Lys 
                85                  90                  95      


Gly Arg Cys Gly His Asn Glu Ser Glu Leu Gln Val Phe Trp Val Asp 
            100                 105                 110         


Arg Ala Tyr Thr Leu Lys Met Leu Phe Val Lys Glu Ser His Asn Thr 
        115                 120                 125             


Ser Lys Gly Leu Glu Ala Thr Trp Lys Leu Ser Lys Val Gln Phe Val 
    130                 135                 140                 


Tyr Asp Ser Ser Glu Lys Thr His Phe Lys Asp Ala Val Ser Ala Gly 
145                 150                 155                 160 


Lys His Thr Ala Asn Ser His His Leu Ser Ala Leu Val Thr Pro Ala 
                165                 170                 175     


Gly Met Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser Leu Ala Ser 
            180                 185                 190         


Ser Asp Pro Gln Lys Thr Val Thr Met Ile Leu Ser Ala Val His Ile 
        195                 200                 205             


Gln Pro Phe Asp Ile Ile Ser Asp Phe Val Phe Ser Glu Glu His Lys 
    210                 215                 220                 


Cys Pro Val Asp Glu Arg Glu Gln Leu Glu Glu Thr Leu Pro Leu Ile 
225                 230                 235                 240 


Leu Gly Leu Ile Leu Gly Leu Val Ile Val Ile Thr Leu Val Ile Tyr 
                245                 250                 255     


His Ile His His Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp 
            260                 265                 270         


Arg Ser Gln Tyr Lys His Met Gly 
        275                 280 


<210>  100
<211>  299
<212>  PRT
<213>  Gallus gallus

<400>  100

Met Ala Ala Gly Arg Leu Pro Gly Leu Leu Phe Leu Leu His Ala Ala 
1               5                   10                  15      


Ala Arg Leu Ala Ala Glu Gln Glu Val Glu Asn Leu Ser Gly Leu Ser 
            20                  25                  30          


Pro Asn Pro Glu Lys Asp Ile Phe Val Val Arg Glu Asn Arg Thr Thr 
        35                  40                  45              


Cys Leu Met Ala Glu Phe Ala Ala Lys Phe Val Val Pro Tyr Asp Val 
    50                  55                  60                  


Trp Ala Ser Asn Tyr Val Asp Leu Ile Thr Glu Gln Ala Asp Ile Pro 
65                  70                  75                  80  


Leu Ser Arg Gly Ala Glu Met Lys Gly Lys Cys Gly Thr Asn Glu Ser 
                85                  90                  95      


Glu Leu Glu Ile Ser Trp Leu Glu Arg Ala Tyr Thr Leu Lys Leu Phe 
            100                 105                 110         


Phe Leu Lys Val Arg Gly Cys Pro Arg Arg Leu Gly Arg Gly Arg Cys 
        115                 120                 125             


Ala Ala Ala Leu Arg Gly Pro Asp Gln Pro Cys Pro Pro Gln Glu Gly 
    130                 135                 140                 


His Asn Thr Ser Arg Gly Pro Glu Ala Phe Trp Arg Leu Ser Arg Ile 
145                 150                 155                 160 


Gln Phe Ser Tyr Asp Thr Ser Glu Arg Thr Tyr Phe Lys Asp Ala Val 
                165                 170                 175     


Ser Pro Gly Lys His Thr Ala Ser Ser His Arg Leu Ser Ala Leu Val 
            180                 185                 190         


Thr Pro Ala Gly Lys Ser Tyr Glu Cys Gln Ala Gln Gln Thr Ile Ser 
        195                 200                 205             


Leu Ile Ser Ser Asp His Gln Lys Ser Val Gln Leu Leu Leu Ser Glu 
    210                 215                 220                 


Val Arg Ile Gln Pro Phe Asp Ile Thr Ala Asp Phe Val Phe Ser Glu 
225                 230                 235                 240 


Glu His Lys Cys Pro Val Asp Gln Arg Glu Gln Leu Glu Glu Thr Leu 
                245                 250                 255     


Pro Leu Ile Leu Gly Leu Ile Leu Gly Leu Val Ile Val Ile Thr Leu 
            260                 265                 270         


Cys Val Tyr His Ile His His Lys Leu Thr Ala Asn Gln Val Gln Ile 
        275                 280                 285             


Pro Arg Asp Arg Ser Gln Tyr Lys His Met Gly 
    290                 295                 


<210>  101
<211>  276
<212>  PRT
<213>  Xenopus tropicalis

<400>  101

Met Asp Tyr Arg Ala Cys Thr Ser Ala Leu Arg Met Pro Val Leu Leu 
1               5                   10                  15      


Leu Leu Leu Cys Thr Phe Ser Cys Asn Leu Ala Glu Gln Glu Val Glu 
            20                  25                  30          


Asn Leu Ser Gly Leu Ser Ser Asn Pro Asp Lys Asn Ile Phe Ala Ile 
        35                  40                  45              


Arg Glu Asn Gly Thr Thr Cys Leu Met Ala Glu Phe Ser Ala Arg Ile 
    50                  55                  60                  


Leu Val Pro Tyr Glu Val Pro Ser Ser Asn Glu Val Asp Trp Asp Leu 
65                  70                  75                  80  


Glu Glu Ala Ser Ile Gln Leu Pro Arg Asp Thr Glu Ile Arg Gly Lys 
                85                  90                  95      


Cys Trp Asn Asn Glu Ser Glu Leu His Leu Ser Trp Leu Asp Lys Ala 
            100                 105                 110         


Tyr Thr Leu Lys Leu Phe Phe Ser Lys Glu Gly Gln Asp Ala Ser Lys 
        115                 120                 125             


Ser Arg Ser Trp Lys Met Ser Lys Ile Gln Phe Leu Tyr Asp Pro Ser 
    130                 135                 140                 


Glu His Thr Ile Phe Lys Ser Gly Ala Arg Pro Gly Arg His Thr Ala 
145                 150                 155                 160 


Asn Ser His His Leu Ser Leu Met Val Thr Pro Ala Gly Met Ser Tyr 
                165                 170                 175     


Glu Cys Glu Ala Thr Gln Arg Ile Ser Leu Thr Ser Thr Asp His Gln 
            180                 185                 190         


Lys Ile Val Val Leu Tyr Leu Ser Glu Val His Leu Gln Pro Phe Asp 
        195                 200                 205             


Ile Lys Ser Asp Phe Val Tyr Ser Glu Glu Tyr Lys Cys Pro Thr Asp 
    210                 215                 220                 


Gln Arg Lys Gln Leu Glu Glu Thr Leu Pro Leu Ile Leu Gly Leu Thr 
225                 230                 235                 240 


Leu Gly Val Ala Ile Leu Ile Ile Val Ala Val Tyr His Ile His His 
                245                 250                 255     


Lys Met Thr Ala Asn Gln Val Gln Ile Pro Arg Asp Arg Ser Leu Tyr 
            260                 265                 270         


Lys His Met Gly 
        275     


<210>  102
<211>  338
<212>  PRT
<213>  Rattus norvegicus

<400>  102

Met Val Gly Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ala Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Leu Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Phe Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  103
<211>  338
<212>  PRT
<213>  Equus caballus

<400>  103

Met Val Gly Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Thr Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Ala Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Asn Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  104
<211>  338
<212>  PRT
<213>  Sus scrofa

<400>  104

Met Val Ala Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Leu Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Lys Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Asn Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  105
<211>  338
<212>  PRT
<213>  Bos taurus

<400>  105

Met Val Ala Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Lys Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Asn Leu Gly Met Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  106
<211>  417
<212>  PRT
<213>  Anopheles gambiae str. PEST

<400>  106

Met Ser Phe Ala Gly Glu Ala Ala Ser Gln Ile Leu Asn Lys Ala Glu 
1               5                   10                  15      


Pro Leu Phe Ile Ser Arg Ser Glu Ala Phe Lys Phe Ala Val Gly Asp 
            20                  25                  30          


Thr Ile Thr Leu Pro Cys Glu Val Ala Ser Pro Gly Thr Tyr Val Leu 
        35                  40                  45              


Ala Trp Lys Arg Gly Ile Ala Ile Leu Thr Ala Gly Ser Val Lys Val 
    50                  55                  60                  


Thr Pro Asp Pro Arg Val Arg Leu Val Asn Gly Tyr Ser Leu Gln Ile 
65                  70                  75                  80  


Arg Asp Ala Val Pro Gln Asp Ala Gly Asp Tyr Ile Cys Gln Ile Ala 
                85                  90                  95      


Met Leu Asp Pro Arg Glu Ile Thr His Ser Val Glu Ile Leu Val Pro 
            100                 105                 110         


Pro Lys Ile Thr His Val Thr Ser Gly Gly His Leu Gln Val Arg Lys 
        115                 120                 125             


Gly Ser Pro Val Arg Leu Glu Cys Ser Ala Thr Gly Asn Pro Met Pro 
    130                 135                 140                 


Asn Ile Thr Trp Thr Arg Lys Asn Asn Leu Leu Pro Asn Gly Glu Glu 
145                 150                 155                 160 


Gln Phe Thr Asn Pro Val Tyr Val Ile Glu Asn Met Asp Arg His Lys 
                165                 170                 175     


Gly Gly Thr Tyr Ile Cys Thr Ala Asn Asn Gly Val Gly Gln Val Ala 
            180                 185                 190         


Thr Ser Gln Ile Ile Leu His Val Leu Tyr Pro Pro Glu Ile Ser Val 
        195                 200                 205             


Glu Asn Pro Thr Val Tyr Ser Gly Glu Gly Gln Glu Ala Met Leu Val 
    210                 215                 220                 


Cys Ile Val His Gly Glu Ser Gln Pro Glu Val Leu Trp His Lys Asp 
225                 230                 235                 240 


Thr Met Gln Ile Asp Gln Thr Glu Arg His Val Ile Glu Asn Arg Gly 
                245                 250                 255     


Ala Arg His Thr Leu Ile Ile Arg Lys Val His Pro Gln Asp Phe Gly 
            260                 265                 270         


Asn Tyr Ser Cys Ile Ala Asp Asn Gln Leu Gly Lys Thr Arg Lys Thr 
        275                 280                 285             


Val Thr Leu Thr Gly Lys Pro Lys Thr Ala Val Phe Arg Ser Val Pro 
    290                 295                 300                 


Asn Ser Gln Trp Lys Asp Lys Tyr Asn Ile Ser Trp Ile Val Asp Ser 
305                 310                 315                 320 


His Ser Pro Ile Glu Glu Phe Lys Leu Tyr Tyr Arg Gln Met Thr Phe 
                325                 330                 335     


Ser Ile Gly Gln Leu Gln Pro Leu Gln Thr Asp Trp Arg Asp Ile Val 
            340                 345                 350         


Leu Pro Ala Phe Pro Tyr Ser His His Tyr Thr Gln Gly Met Ser Tyr 
        355                 360                 365             


Leu Ile Arg Gly Leu Glu Pro Asp Gln Gln Tyr Glu Ala Arg Val Gln 
    370                 375                 380                 


Ser Arg Asn Arg Tyr Gly Trp Ser Asp Phe Ser Glu Ser Phe Leu Phe 
385                 390                 395                 400 


Thr Thr Ser Asn Thr Gly Lys Trp Met Gly Gln Cys Cys Thr Asn Pro 
                405                 410                 415     


Gly 
    


<210>  107
<211>  334
<212>  PRT
<213>  Xenopus tropicalis

<400>  107

Met Arg Pro Cys Leu Leu His Ser Ile Trp Met Leu Gly Phe Val Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gln Gly Leu Pro Val Arg Ser Gly Asp Phe Asn 
            20                  25                  30          


Arg Ser Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr Ala Ile Leu 
        35                  40                  45              


Arg Cys Phe Val Glu Asp Arg Ser Ser Arg Val Ala Trp Leu Asn Arg 
    50                  55                  60                  


Ser Gly Ile Ile Phe Ala Gly Asp Asp Lys Trp Ser Leu Asp Pro Arg 
65                  70                  75                  80  


Val Glu Leu Glu Lys Arg Ser Leu Leu Glu Tyr Ser Leu Arg Ile Gln 
                85                  90                  95      


Lys Val Asp Val Ser Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr 
            100                 105                 110         


Lys Gln His Thr Lys Thr Thr Gln Val Tyr Leu Ile Val Gln Val Pro 
        115                 120                 125             


Pro Lys Ile Ser Asn Ile Ser Ala Asp Ile Thr Val Asn Glu Gly Ser 
    130                 135                 140                 


Asn Val Thr Leu Met Cys Ile Ala Tyr Gly Arg Pro Glu Pro Met Ile 
145                 150                 155                 160 


Thr Trp Arg His Leu Thr Pro Thr Ala Arg Asp Phe Glu Gly Glu Glu 
                165                 170                 175     


Glu Phe Leu Glu Ile Gln Gly Ile Thr Arg Glu Gln Ser Gly Arg Tyr 
            180                 185                 190         


Glu Cys Lys Ala Ala Asn Glu Val Ala Ser Ala Asp Val Lys Gln Val 
        195                 200                 205             


Arg Val Thr Val Asn Tyr Pro Pro Ile Ile Thr Glu Ser Lys Ser Asn 
    210                 215                 220                 


Glu Ala Thr Thr Gly Lys Gln Ala Ile Leu Arg Cys Glu Ala Ser Ala 
225                 230                 235                 240 


Val Pro Ala Pro Asp Phe Glu Trp Tyr Lys Asp Asp Thr Arg Ile Asn 
                245                 250                 255     


Ser Ala Gln Gly Leu Glu Ile Arg Asn Thr Gly Ser Arg Ser Val Leu 
            260                 265                 270         


Met Val Ala Asn Val Thr Glu Glu His Tyr Gly Asn Tyr Thr Cys Val 
        275                 280                 285             


Ala Ala Asn Lys Leu Gly Ile Thr Asn Thr Ser Leu Tyr Leu Tyr Ile 
    290                 295                 300                 


Gly Pro Gly Thr Pro Ile Asp Ser Ala Thr Ser Leu Ala Ala Ser Leu 
305                 310                 315                 320 


Trp Leu Met Ala Asn Leu Leu Phe Cys Leu Phe Cys Thr Cys 
                325                 330                 


<210>  108
<211>  338
<212>  PRT
<213>  Canis lupus familiaris

<400>  108

Met Leu Gly Ala Arg Arg Pro Pro Arg Ser Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Arg Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Lys Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Asn Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  109
<211>  338
<212>  PRT
<213>  Monodelphis domestica

<400>  109

Met Val Gly Arg Val His Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Gly Val 
            20                  25                  30          


Asp Phe Thr Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Tyr Val Glu Asp Lys Ser Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg Thr Ala Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Gln Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Ile Glu Gly Gln 
            260                 265                 270         


Ser Leu Leu Met Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Ile 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Phe Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  110
<211>  338
<212>  PRT
<213>  Gallus gallus

<400>  110

Met Val Ala Arg Ala Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Thr Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Phe Val Glu Asp Arg Ser Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly Glu Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg Ser Pro Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His His Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Ile Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Lys Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ala Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Arg Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Ala Thr Gly Arg Gln Ala Leu Leu Arg Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Thr Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Gly Ser Gln 
            260                 265                 270         


Ser Leu Leu Met Val Ala Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Tyr 
    290                 295                 300                 


Leu Tyr Arg Pro Gly Thr Gly Arg Val Asp Asn Gly Ser Val Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  111
<211>  335
<212>  PRT
<213>  Taeniopygia guttata

<400>  111

Met Arg Thr Tyr Trp Leu His Ser Ile Trp Val Leu Gly Phe Phe Leu 
1               5                   10                  15      


Ser Leu Phe Ser Leu Gln Gly Leu Pro Val Arg Ser Val Asp Phe Thr 
            20                  25                  30          


Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr Ala Ile Leu 
        35                  40                  45              


Arg Cys Tyr Val Glu Asp Arg Ser Ser Lys Val Ala Trp Leu Asn Arg 
    50                  55                  60                  


Ser Gly Ile Ile Phe Ala Gly Glu Asp Lys Trp Ser Leu Asp Pro Arg 
65                  70                  75                  80  


Val Glu Leu Glu Lys Arg Asn Pro Leu Glu Tyr Ser Leu Arg Ile Gln 
                85                  90                  95      


Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser Val Gln Thr 
            100                 105                 110         


Gln His His Pro Lys Thr Ser Gln Val Tyr Leu Ile Val Gln Val Pro 
        115                 120                 125             


Pro Lys Ile Ser Asn Ile Ser Ser Asp Ile Thr Val Asn Glu Gly Ser 
    130                 135                 140                 


Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu Pro Val Ile 
145                 150                 155                 160 


Thr Trp Arg His Leu Thr Pro Thr Gly Lys Glu Phe Glu Gly Glu Glu 
                165                 170                 175     


Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser Gly Lys Tyr 
            180                 185                 190         


Glu Cys Lys Ala Ala Asn Glu Val Ala Ser Ala Asp Val Lys Gln Val 
        195                 200                 205             


Arg Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser Lys Ser Asn 
    210                 215                 220                 


Glu Ala Ala Thr Gly Arg Gln Ala Leu Leu Arg Cys Glu Ala Ser Ala 
225                 230                 235                 240 


Val Pro Thr Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr Arg Ile Asn 
                245                 250                 255     


Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Gly Ser Gln Ser Leu Leu 
            260                 265                 270         


Met Val Ala Asn Val Thr Glu Glu His Tyr Gly Asn Tyr Thr Cys Val 
        275                 280                 285             


Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Tyr Leu Tyr Arg 
    290                 295                 300                 


Pro Gly Thr Gly Arg Val Asp Asn Gly Ser Met Ser Leu Ala Val Pro 
305                 310                 315                 320 


Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser Lys Cys 
                325                 330                 335 


<210>  112
<211>  334
<212>  PRT
<213>  Xenopus tropicalis

<400>  112

Met Arg Pro Cys Leu Leu His Ser Ile Trp Met Leu Gly Phe Val Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gln Gly Leu Pro Val Arg Ser Gly Asp Phe Asn 
            20                  25                  30          


Arg Ser Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr Ala Ile Leu 
        35                  40                  45              


Arg Cys Phe Val Glu Asp Arg Ser Ser Arg Val Ala Trp Leu Asn Arg 
    50                  55                  60                  


Ser Gly Ile Ile Phe Ala Gly Asp Asp Lys Trp Ser Leu Asp Pro Arg 
65                  70                  75                  80  


Val Glu Leu Glu Lys Arg Ser Leu Leu Glu Tyr Ser Leu Arg Ile Gln 
                85                  90                  95      


Lys Val Asp Val Ser Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr 
            100                 105                 110         


Lys Gln His Thr Lys Thr Thr Gln Val Tyr Leu Ile Val Gln Val Pro 
        115                 120                 125             


Pro Lys Ile Ser Asn Ile Ser Ala Asp Ile Thr Val Asn Glu Gly Ser 
    130                 135                 140                 


Asn Val Thr Leu Met Cys Ile Ala Tyr Gly Arg Pro Glu Pro Met Ile 
145                 150                 155                 160 


Thr Trp Arg His Leu Thr Pro Thr Ala Arg Asp Phe Glu Gly Glu Glu 
                165                 170                 175     


Glu Phe Leu Glu Ile Gln Gly Ile Thr Arg Glu Gln Ser Gly Arg Tyr 
            180                 185                 190         


Glu Cys Lys Ala Ala Asn Glu Val Ala Ser Ala Asp Val Lys Gln Val 
        195                 200                 205             


Arg Val Thr Val Asn Tyr Pro Pro Ile Ile Thr Glu Ser Lys Ser Asn 
    210                 215                 220                 


Glu Ala Thr Thr Gly Lys Gln Ala Ile Leu Arg Cys Glu Ala Ser Ala 
225                 230                 235                 240 


Val Pro Ala Pro Asp Phe Glu Trp Tyr Lys Asp Asp Thr Arg Ile Asn 
                245                 250                 255     


Ser Ala Gln Gly Leu Glu Ile Arg Asn Thr Gly Ser Arg Ser Val Leu 
            260                 265                 270         


Met Val Ala Asn Val Thr Glu Glu His Tyr Gly Asn Tyr Thr Cys Val 
        275                 280                 285             


Ala Ala Asn Lys Leu Gly Ile Thr Asn Thr Ser Leu Tyr Leu Tyr Ile 
    290                 295                 300                 


Gly Pro Gly Thr Pro Ile Asp Ser Ala Thr Ser Leu Ala Ala Ser Leu 
305                 310                 315                 320 


Trp Leu Met Ala Asn Leu Leu Phe Cys Leu Phe Cys Thr Cys 
                325                 330                 


<210>  113
<211>  337
<212>  PRT
<213>  Oreochromis niloticus

<400>  113

Met Gln Val Gly Arg Lys Ser Cys Trp Arg Gln Leu Gln Ala Ser Phe 
1               5                   10                  15      


Phe Arg Leu Leu Cys Leu Ile Pro Thr Gly Phe Pro Val Arg Ser Val 
            20                  25                  30          


Asp Met Gln Arg Ala Thr Asp Asn Ile Thr Ile Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Ile Arg Cys Tyr Val Asp Asp Lys Val Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Asn Ile Ile Phe Ala Gly Gln Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Asp Leu Val Thr Lys Gly Gln Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Ile Gln Thr Lys Gln Gln Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Ala Ser Ile Tyr Gln Val Ser Asn Asp Ile Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Ser Cys Leu Ala Asn Gly Arg Pro Asp 
145                 150                 155                 160 


Pro Ala Ile Thr Trp Arg Leu Leu Asn Pro Ser Ala Glu Pro Leu Asp 
                165                 170                 175     


Gly Glu Glu Tyr Leu Asp Ile Ile Gly Ile Met Arg Thr Gln Ala Gly 
            180                 185                 190         


Arg Tyr Glu Cys Lys Ala Ser Asn Asp Val Ala Thr Pro Asp Val Lys 
        195                 200                 205             


Tyr Val Asn Val Ile Val Asn Tyr Pro Pro Thr Ile Lys Lys Thr Gln 
    210                 215                 220                 


Ser Ser Glu Thr Pro Val Gly Arg Asn Gly Thr Leu Arg Cys Glu Val 
225                 230                 235                 240 


Thr Ala Val Pro Thr Pro Glu Phe Glu Trp Tyr Arg Asp Asp Lys Arg 
                245                 250                 255     


Leu Ala Asn Thr Gln Ser Ile Thr Ile Gln Thr Ser Gly Thr Thr Thr 
            260                 265                 270         


Ser Leu Thr Ile Ala Asn Ile Thr Glu Glu Asp Tyr Gly Asn Tyr Thr 
        275                 280                 285             


Cys Val Ala Ser Asn Arg Leu Gly Val Gln Asn Ala Ser Leu Phe Leu 
    290                 295                 300                 


Tyr Arg Pro Gly Thr Gly Arg Asp Ile Asn Gly Ser Ala Cys Val Ser 
305                 310                 315                 320 


Gln Ser Leu Trp Leu Leu Leu Ala Ser Phe Ala Cys Leu Phe Leu Lys 
                325                 330                 335     


Cys 
    


<210>  114
<211>  492
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  114
ctcgagatgg gcgtgttctg ctacgaggac gaggccacaa gcgtgatccc tcccgccaga       60

ctgttcaaga gcttcgtgct ggacgccgac aatctgatcc ccaaagtggc cccccagcac      120

ttcaccagcg ccgagaatct ggaaggcaat ggcggacccg gcaccatcaa gaagatcaca      180

ttcgccgagg gcaacgagtt caagtacatg aagcacaaag tggaagagat cgaccacgcc      240

aacttcaagt actgctacag catcatcgaa ggcggccctc tgggccacac actggaaaag      300

atcagctacg agatcaagat ggccgctgcc cctcacggcg gaggcagcat tctgaagatc      360

accagcaagt accacaccaa gggcaacgcc agcatcaacg aggaagaaat caaggccggc      420

aaagagaaag ccgccggact gtttaaggcc gtggaagcct atctgctggc ccaccccgat      480

gcctacgaat tc                                                          492


<210>  115
<211>  160
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  115

Met Gly Val Phe Cys Tyr Glu Asp Glu Ala Thr Ser Val Ile Pro Pro 
1               5                   10                  15      


Ala Arg Leu Phe Lys Ser Phe Val Leu Asp Ala Asp Asn Leu Ile Pro 
            20                  25                  30          


Lys Val Ala Pro Gln His Phe Thr Ser Ala Glu Asn Leu Glu Gly Asn 
        35                  40                  45              


Gly Gly Pro Gly Thr Ile Lys Lys Ile Thr Phe Ala Glu Gly Asn Glu 
    50                  55                  60                  


Phe Lys Tyr Met Lys His Lys Val Glu Glu Ile Asp His Ala Asn Phe 
65                  70                  75                  80  


Lys Tyr Cys Tyr Ser Ile Ile Glu Gly Gly Pro Leu Gly His Thr Leu 
                85                  90                  95      


Glu Lys Ile Ser Tyr Glu Ile Lys Met Ala Ala Ala Pro His Gly Gly 
            100                 105                 110         


Gly Ser Ile Leu Lys Ile Thr Ser Lys Tyr His Thr Lys Gly Asn Ala 
        115                 120                 125             


Ser Ile Asn Glu Glu Glu Ile Lys Ala Gly Lys Glu Lys Ala Ala Gly 
    130                 135                 140                 


Leu Phe Lys Ala Val Glu Ala Tyr Leu Leu Ala His Pro Asp Ala Tyr 
145                 150                 155                 160 


<210>  116
<211>  906
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  116
ctcgagatca acgtgggact gcggagacag cagcagcggt acttcggcga gtgcaatctg       60

gaccggctga acgctctgga acccaccaac agaatcgagg ccgaggcttg ccagatcgag      120

agctgggacc acaacgacca gcagttccag tgtgctggcg tggccgtgat cagacggacc      180

atcgagccca acggactgct gctgccccag tacagcaatg cccccgagct gatctacatc      240

gagcggggca gaggaatcac cggcgtgctg tttcccggct gccccgagac attcgaggac      300

cctcagcagc agagccagca aggccagaga caaggccaag gccagtccca gagaagcgag      360

caagaccggc accagaagat ccggcacttc agagagggcg acatcattgc tctgccagcc      420

ggcgtggccc actggtgcta caatgatggc gatagccccg tcgtgaccgt gtctctgctg      480

cacaccaaca actacgccaa ccagctggac gagaacccca gacacttcta tctggccggc      540

aaccccgacg acgagcacca gaggcaaggg cagcagcagt tcggccagag aagaaggcag      600

cagcagcaca gccatggcga gcaaggcgag caagagcagc aaggcgaggg caacaacgtg      660

ttcagcggct tcgacgccga gtttctggcc gacgccttca acgtggacgt ggacacagcc      720

agacggctgc agtccaacca agacaagcgg cggaacatcg tgaaagtgga aggccggctc      780

caagtcgtgc ggcccgagag atctagacaa gagtgggagc ggcaagagcg gcaagaacgc      840

gagagcgagc aagagagaga gcggcagaga aggcaaggcg gcagaggcag agatgtgaac      900

gaattc                                                                 906


<210>  117
<211>  298
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  117

Ile Asn Val Gly Leu Arg Arg Gln Gln Gln Arg Tyr Phe Gly Glu Cys 
1               5                   10                  15      


Asn Leu Asp Arg Leu Asn Ala Leu Glu Pro Thr Asn Arg Ile Glu Ala 
            20                  25                  30          


Glu Ala Cys Gln Ile Glu Ser Trp Asp His Asn Asp Gln Gln Phe Gln 
        35                  40                  45              


Cys Ala Gly Val Ala Val Ile Arg Arg Thr Ile Glu Pro Asn Gly Leu 
    50                  55                  60                  


Leu Leu Pro Gln Tyr Ser Asn Ala Pro Glu Leu Ile Tyr Ile Glu Arg 
65                  70                  75                  80  


Gly Arg Gly Ile Thr Gly Val Leu Phe Pro Gly Cys Pro Glu Thr Phe 
                85                  90                  95      


Glu Asp Pro Gln Gln Gln Ser Gln Gln Gly Gln Arg Gln Gly Gln Gly 
            100                 105                 110         


Gln Ser Gln Arg Ser Glu Gln Asp Arg His Gln Lys Ile Arg His Phe 
        115                 120                 125             


Arg Glu Gly Asp Ile Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys 
    130                 135                 140                 


Tyr Asn Asp Gly Asp Ser Pro Val Val Thr Val Ser Leu Leu His Thr 
145                 150                 155                 160 


Asn Asn Tyr Ala Asn Gln Leu Asp Glu Asn Pro Arg His Phe Tyr Leu 
                165                 170                 175     


Ala Gly Asn Pro Asp Asp Glu His Gln Arg Gln Gly Gln Gln Gln Phe 
            180                 185                 190         


Gly Gln Arg Arg Arg Gln Gln Gln His Ser His Gly Glu Gln Gly Glu 
        195                 200                 205             


Gln Glu Gln Gln Gly Glu Gly Asn Asn Val Phe Ser Gly Phe Asp Ala 
    210                 215                 220                 


Glu Phe Leu Ala Asp Ala Phe Asn Val Asp Val Asp Thr Ala Arg Arg 
225                 230                 235                 240 


Leu Gln Ser Asn Gln Asp Lys Arg Arg Asn Ile Val Lys Val Glu Gly 
                245                 250                 255     


Arg Leu Gln Val Val Arg Pro Glu Arg Ser Arg Gln Glu Trp Glu Arg 
            260                 265                 270         


Gln Glu Arg Gln Glu Arg Glu Ser Glu Gln Glu Arg Glu Arg Gln Arg 
        275                 280                 285             


Arg Gln Gly Gly Arg Gly Arg Asp Val Asn 
    290                 295             


<210>  118
<211>  1410
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  118
catatgctcg agatgggcgt gttctgctac gaggacgagg ccacaagcgt gatccctccc       60

gccagactgt tcaagagctt cgtgctggac gccgacaatc tgatccccaa agtggccccc      120

cagcacttca ccagcgccga gaatctggaa ggcaatggcg gacccggcac catcaagaag      180

atcacattcg ccgagggcaa cgagttcaag tacatgaagc acaaagtgga agagatcgac      240

cacgccaact tcaagtactg ctacagcatc atcgaaggcg gccctctggg ccacacactg      300

gaaaagatca gctacgagat caagatggcc gctgcccctc acggcggagg cagcattctg      360

aagatcacca gcaagtacca caccaagggc aacgccagca tcaacgagga agaaatcaag      420

gccggcaaag agaaagccgc cggactgttt aaggccgtgg aagcctatct gctggcccac      480

cccgatgcct acggcggagg gggcatcaac gtgggactgc ggagacagca gcagcggtac      540

ttcggcgagt gcaatctgga ccggctgaac gctctggaac ccaccaacag aatcgaggcc      600

gaggcttgcc agatcgagag ctgggaccac aacgaccagc agttccagtg tgctggcgtg      660

gccgtgatca gacggaccat cgagcccaac ggactgctgc tgccccagta cagcaatgcc      720

cccgagctga tctacatcga gcggggcaga ggaatcaccg gcgtgctgtt tcccggctgc      780

cccgagacat tcgaggaccc tcagcagcag agccagcaag gccagagaca aggccaaggc      840

cagtcccaga gaagcgagca agaccggcac cagaagatcc ggcacttcag agagggcgac      900

atcattgctc tgccagccgg cgtggcccac tggtgctaca atgatggcga tagccccgtc      960

gtgaccgtgt ctctgctgca caccaacaac tacgccaacc agctggacga gaaccccaga     1020

cacttctatc tggccggcaa ccccgacgac gagcaccaga ggcaagggca gcagcagttc     1080

ggccagagaa gaaggcagca gcagcacagc catggcgagc aaggcgagca agagcagcaa     1140

ggcgagggca acaacgtgtt cagcggcttc gacgccgagt ttctggccga cgccttcaac     1200

gtggacgtgg acacagccag acggctgcag tccaaccaag acaagcggcg gaacatcgtg     1260

aaagtggaag gccggctcca agtcgtgcgg cccgagagat ctagacaaga gtgggagcgg     1320

caagagcggc aagaacgcga gagcgagcaa gagagagagc ggcagagaag gcaaggcggc     1380

agaggcagag atgtgaacga attcgtcgac                                      1410


<210>  119
<211>  462
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  119

Met Gly Val Phe Cys Tyr Glu Asp Glu Ala Thr Ser Val Ile Pro Pro 
1               5                   10                  15      


Ala Arg Leu Phe Lys Ser Phe Val Leu Asp Ala Asp Asn Leu Ile Pro 
            20                  25                  30          


Lys Val Ala Pro Gln His Phe Thr Ser Ala Glu Asn Leu Glu Gly Asn 
        35                  40                  45              


Gly Gly Pro Gly Thr Ile Lys Lys Ile Thr Phe Ala Glu Gly Asn Glu 
    50                  55                  60                  


Phe Lys Tyr Met Lys His Lys Val Glu Glu Ile Asp His Ala Asn Phe 
65                  70                  75                  80  


Lys Tyr Cys Tyr Ser Ile Ile Glu Gly Gly Pro Leu Gly His Thr Leu 
                85                  90                  95      


Glu Lys Ile Ser Tyr Glu Ile Lys Met Ala Ala Ala Pro His Gly Gly 
            100                 105                 110         


Gly Ser Ile Leu Lys Ile Thr Ser Lys Tyr His Thr Lys Gly Asn Ala 
        115                 120                 125             


Ser Ile Asn Glu Glu Glu Ile Lys Ala Gly Lys Glu Lys Ala Ala Gly 
    130                 135                 140                 


Leu Phe Lys Ala Val Glu Ala Tyr Leu Leu Ala His Pro Asp Ala Tyr 
145                 150                 155                 160 


Gly Gly Gly Gly Ile Asn Val Gly Leu Arg Arg Gln Gln Gln Arg Tyr 
                165                 170                 175     


Phe Gly Glu Cys Asn Leu Asp Arg Leu Asn Ala Leu Glu Pro Thr Asn 
            180                 185                 190         


Arg Ile Glu Ala Glu Ala Cys Gln Ile Glu Ser Trp Asp His Asn Asp 
        195                 200                 205             


Gln Gln Phe Gln Cys Ala Gly Val Ala Val Ile Arg Arg Thr Ile Glu 
    210                 215                 220                 


Pro Asn Gly Leu Leu Leu Pro Gln Tyr Ser Asn Ala Pro Glu Leu Ile 
225                 230                 235                 240 


Tyr Ile Glu Arg Gly Arg Gly Ile Thr Gly Val Leu Phe Pro Gly Cys 
                245                 250                 255     


Pro Glu Thr Phe Glu Asp Pro Gln Gln Gln Ser Gln Gln Gly Gln Arg 
            260                 265                 270         


Gln Gly Gln Gly Gln Ser Gln Arg Ser Glu Gln Asp Arg His Gln Lys 
        275                 280                 285             


Ile Arg His Phe Arg Glu Gly Asp Ile Ile Ala Leu Pro Ala Gly Val 
    290                 295                 300                 


Ala His Trp Cys Tyr Asn Asp Gly Asp Ser Pro Val Val Thr Val Ser 
305                 310                 315                 320 


Leu Leu His Thr Asn Asn Tyr Ala Asn Gln Leu Asp Glu Asn Pro Arg 
                325                 330                 335     


His Phe Tyr Leu Ala Gly Asn Pro Asp Asp Glu His Gln Arg Gln Gly 
            340                 345                 350         


Gln Gln Gln Phe Gly Gln Arg Arg Arg Gln Gln Gln His Ser His Gly 
        355                 360                 365             


Glu Gln Gly Glu Gln Glu Gln Gln Gly Glu Gly Asn Asn Val Phe Ser 
    370                 375                 380                 


Gly Phe Asp Ala Glu Phe Leu Ala Asp Ala Phe Asn Val Asp Val Asp 
385                 390                 395                 400 


Thr Ala Arg Arg Leu Gln Ser Asn Gln Asp Lys Arg Arg Asn Ile Val 
                405                 410                 415     


Lys Val Glu Gly Arg Leu Gln Val Val Arg Pro Glu Arg Ser Arg Gln 
            420                 425                 430         


Glu Trp Glu Arg Gln Glu Arg Gln Glu Arg Glu Ser Glu Gln Glu Arg 
        435                 440                 445             


Glu Arg Gln Arg Arg Gln Gly Gly Arg Gly Arg Asp Val Asn 
    450                 455                 460         


<210>  120
<211>  1053
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  120
ctcgaggcca gacagagcca gctgagcccc cagaatcagt gccagctgaa ccagctgcaa       60

gccagagagc ccgacaaccg gattcaagcc gaggccggcc agatcgagac atggaacttc      120

aaccaagagg acttccagtg tgccggcgtg gccgccagca gaatcaccat ccagcggaac      180

ggactgcatc tgcccagcta cagcaacgcc ccccagctga tctacatcgt gcaaggcaga      240

ggcgtgctgg gcgccgtgtt tagcggatgc cccgagacat tcgaggaaag ccagcagagc      300

agccagcaag gccggcagca agagcaagaa caagagagac aacagcagca gcaaggggag      360

caaggcagac agcaaggaca gcaagagcag cagcaagagc gccaaggacg gcagcaaggg      420

cgccagcagc aagaagaggg cagacagcaa gaacagcagc aaggccagca agggcggcct      480

cagcagcagc agcagttccg gcagttcgac cggcaccaga aaacccggcg gatcagagaa      540

ggcgacgtgg tggctattcc agccggggtg gcctactggt cctacaacga cggcgaccaa      600

gaactggtgg ccgtgaatct gttccacgtg tccagcgacc acaaccagct ggaccagaac      660

ccccggaagt tctatctggc tggcaacccc gagaacgagt tcaaccagca agggcagagc      720

cagcccagac agcaaggcga acaaggacgg cccggacagc accagcagcc tttcggcaga      780

ccacggcagc aagagcagca aggcagcggc aacaacgtgt tcagcggctt caacacccag      840

ctgctggccc aagctctgaa cgtgaacgag gaaaccgccc ggaatctgca aggccagaac      900

gacaacagaa accagatcat cagagtgcgg ggcaatctgg acttcgtgca gccccctaga      960

gggcggcaag agagagagca cgaagagagg cagcaagaac agctgcagca agagcggcag     1020

cagcaaggcg gacagctgat ggccaacgaa ttc                                  1053


<210>  121
<211>  347
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  121

Ala Arg Gln Ser Gln Leu Ser Pro Gln Asn Gln Cys Gln Leu Asn Gln 
1               5                   10                  15      


Leu Gln Ala Arg Glu Pro Asp Asn Arg Ile Gln Ala Glu Ala Gly Gln 
            20                  25                  30          


Ile Glu Thr Trp Asn Phe Asn Gln Glu Asp Phe Gln Cys Ala Gly Val 
        35                  40                  45              


Ala Ala Ser Arg Ile Thr Ile Gln Arg Asn Gly Leu His Leu Pro Ser 
    50                  55                  60                  


Tyr Ser Asn Ala Pro Gln Leu Ile Tyr Ile Val Gln Gly Arg Gly Val 
65                  70                  75                  80  


Leu Gly Ala Val Phe Ser Gly Cys Pro Glu Thr Phe Glu Glu Ser Gln 
                85                  90                  95      


Gln Ser Ser Gln Gln Gly Arg Gln Gln Glu Gln Glu Gln Glu Arg Gln 
            100                 105                 110         


Gln Gln Gln Gln Gly Glu Gln Gly Arg Gln Gln Gly Gln Gln Glu Gln 
        115                 120                 125             


Gln Gln Glu Arg Gln Gly Arg Gln Gln Gly Arg Gln Gln Gln Glu Glu 
    130                 135                 140                 


Gly Arg Gln Gln Glu Gln Gln Gln Gly Gln Gln Gly Arg Pro Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Phe Arg Gln Phe Asp Arg His Gln Lys Thr Arg Arg Ile 
                165                 170                 175     


Arg Glu Gly Asp Val Val Ala Ile Pro Ala Gly Val Ala Tyr Trp Ser 
            180                 185                 190         


Tyr Asn Asp Gly Asp Gln Glu Leu Val Ala Val Asn Leu Phe His Val 
        195                 200                 205             


Ser Ser Asp His Asn Gln Leu Asp Gln Asn Pro Arg Lys Phe Tyr Leu 
    210                 215                 220                 


Ala Gly Asn Pro Glu Asn Glu Phe Asn Gln Gln Gly Gln Ser Gln Pro 
225                 230                 235                 240 


Arg Gln Gln Gly Glu Gln Gly Arg Pro Gly Gln His Gln Gln Pro Phe 
                245                 250                 255     


Gly Arg Pro Arg Gln Gln Glu Gln Gln Gly Ser Gly Asn Asn Val Phe 
            260                 265                 270         


Ser Gly Phe Asn Thr Gln Leu Leu Ala Gln Ala Leu Asn Val Asn Glu 
        275                 280                 285             


Glu Thr Ala Arg Asn Leu Gln Gly Gln Asn Asp Asn Arg Asn Gln Ile 
    290                 295                 300                 


Ile Arg Val Arg Gly Asn Leu Asp Phe Val Gln Pro Pro Arg Gly Arg 
305                 310                 315                 320 


Gln Glu Arg Glu His Glu Glu Arg Gln Gln Glu Gln Leu Gln Gln Glu 
                325                 330                 335     


Arg Gln Gln Gln Gly Gly Gln Leu Met Ala Asn 
            340                 345         


<210>  122
<211>  1548
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  122
ctcgagaaga tcgaccccga gctgaagcag tgcaagcacc agtgcaaagt gcagcggcag       60

tacgacgagc agcagaaaga acagtgcgtg aaagagtgcg agaagtacta caaagagaag      120

aagggccgcg agcgcgagca cgaagaggaa gaggaagaat ggggcaccgg cggagtggac      180

gagccttcta cacacgagcc cgccgagaaa catctgagcc agtgcatgag acagtgcgaa      240

cggcaagagg gcggccagca gaaacagctg tgccggttcc ggtgccaaga gcggtacaag      300

aaagagcggg gccagcacaa ctacaagaga gaggacgacg aggacgaaga tgaggacgag      360

gctgaggaag aggacgagaa cccctacgtg ttcgaggatg aggacttcac caccaaagtg      420

aaaaccgagc aaggcaaagt ggtgctgctg cccaagttca cccagaagtc caagctgctg      480

cacgctctgg aaaagtaccg gctggccgtt ctggtggcca accctcaagc cttcgtggtg      540

cccagccaca tggacgccga cagcatcttc ttcgtgtctt ggggcagagg caccatcacc      600

aagattctgg aaaacaagcg cgagagcatc aacgtgcggc aaggcgacat cgtgtccatc      660

agcagcggca cccccttcta cattgccaac aacgacgaga acgagaagct gtatctggtg      720

cagtttctgc ggcccgtgaa tctgcccggc cactttgaag tgttccacgg acccggcgga      780

gagaaccccg agagcttcta cagagccttc agctgggaaa ttctggaagc cgctctgaaa      840

acatccaagg acacactgga aaagctgttc gagaagcaag accaagggac catcatgaag      900

gccagcaaag aacagatccg ggccatgagc agaagaggcg agggccccaa gatctggccc      960

ttcaccgagg aaagcaccgg cagcttcaag ctgtttaaga aggaccccag ccagagcaac     1020

aaatacgggc agctgtttga ggccgagcgg atcgactacc ccccactgga aaagctggac     1080

atggtggtgt cctacgccaa tatcaccaag ggcggcatga gcgtgccctt ttacaacagc     1140

agagccacca agatcgccat cgtggtgtcc ggcgagggct gcgtggaaat cgcttgccct     1200

catctgagca gcagcaagtc cagccacccc agctacaaga agctgcgggc cagaatccgg     1260

aaggacaccg tgttcatcgt gccagccggc cacccttttg ccacagtggc cagcggcaac     1320

gagaatctgg aaatcgtgtg cttcgaagtg aacgccgagg gcaacatccg gtacacactg     1380

gccggcaaga agaacatcat caaagtgatg gaaaaggaag ccaaagaact ggcctttaag     1440

atggaaggcg aggaagtgga caaagtgttc ggcaagcaag atgaagagtt cttctttcaa     1500

ggccccgagt ggcgcaaaga gaaagagggc agagccgacg aggaattc                  1548


<210>  123
<211>  512
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  123

Lys Ile Asp Pro Glu Leu Lys Gln Cys Lys His Gln Cys Lys Val Gln 
1               5                   10                  15      


Arg Gln Tyr Asp Glu Gln Gln Lys Glu Gln Cys Val Lys Glu Cys Glu 
            20                  25                  30          


Lys Tyr Tyr Lys Glu Lys Lys Gly Arg Glu Arg Glu His Glu Glu Glu 
        35                  40                  45              


Glu Glu Glu Trp Gly Thr Gly Gly Val Asp Glu Pro Ser Thr His Glu 
    50                  55                  60                  


Pro Ala Glu Lys His Leu Ser Gln Cys Met Arg Gln Cys Glu Arg Gln 
65                  70                  75                  80  


Glu Gly Gly Gln Gln Lys Gln Leu Cys Arg Phe Arg Cys Gln Glu Arg 
                85                  90                  95      


Tyr Lys Lys Glu Arg Gly Gln His Asn Tyr Lys Arg Glu Asp Asp Glu 
            100                 105                 110         


Asp Glu Asp Glu Asp Glu Ala Glu Glu Glu Asp Glu Asn Pro Tyr Val 
        115                 120                 125             


Phe Glu Asp Glu Asp Phe Thr Thr Lys Val Lys Thr Glu Gln Gly Lys 
    130                 135                 140                 


Val Val Leu Leu Pro Lys Phe Thr Gln Lys Ser Lys Leu Leu His Ala 
145                 150                 155                 160 


Leu Glu Lys Tyr Arg Leu Ala Val Leu Val Ala Asn Pro Gln Ala Phe 
                165                 170                 175     


Val Val Pro Ser His Met Asp Ala Asp Ser Ile Phe Phe Val Ser Trp 
            180                 185                 190         


Gly Arg Gly Thr Ile Thr Lys Ile Leu Glu Asn Lys Arg Glu Ser Ile 
        195                 200                 205             


Asn Val Arg Gln Gly Asp Ile Val Ser Ile Ser Ser Gly Thr Pro Phe 
    210                 215                 220                 


Tyr Ile Ala Asn Asn Asp Glu Asn Glu Lys Leu Tyr Leu Val Gln Phe 
225                 230                 235                 240 


Leu Arg Pro Val Asn Leu Pro Gly His Phe Glu Val Phe His Gly Pro 
                245                 250                 255     


Gly Gly Glu Asn Pro Glu Ser Phe Tyr Arg Ala Phe Ser Trp Glu Ile 
            260                 265                 270         


Leu Glu Ala Ala Leu Lys Thr Ser Lys Asp Thr Leu Glu Lys Leu Phe 
        275                 280                 285             


Glu Lys Gln Asp Gln Gly Thr Ile Met Lys Ala Ser Lys Glu Gln Ile 
    290                 295                 300                 


Arg Ala Met Ser Arg Arg Gly Glu Gly Pro Lys Ile Trp Pro Phe Thr 
305                 310                 315                 320 


Glu Glu Ser Thr Gly Ser Phe Lys Leu Phe Lys Lys Asp Pro Ser Gln 
                325                 330                 335     


Ser Asn Lys Tyr Gly Gln Leu Phe Glu Ala Glu Arg Ile Asp Tyr Pro 
            340                 345                 350         


Pro Leu Glu Lys Leu Asp Met Val Val Ser Tyr Ala Asn Ile Thr Lys 
        355                 360                 365             


Gly Gly Met Ser Val Pro Phe Tyr Asn Ser Arg Ala Thr Lys Ile Ala 
    370                 375                 380                 


Ile Val Val Ser Gly Glu Gly Cys Val Glu Ile Ala Cys Pro His Leu 
385                 390                 395                 400 


Ser Ser Ser Lys Ser Ser His Pro Ser Tyr Lys Lys Leu Arg Ala Arg 
                405                 410                 415     


Ile Arg Lys Asp Thr Val Phe Ile Val Pro Ala Gly His Pro Phe Ala 
            420                 425                 430         


Thr Val Ala Ser Gly Asn Glu Asn Leu Glu Ile Val Cys Phe Glu Val 
        435                 440                 445             


Asn Ala Glu Gly Asn Ile Arg Tyr Thr Leu Ala Gly Lys Lys Asn Ile 
    450                 455                 460                 


Ile Lys Val Met Glu Lys Glu Ala Lys Glu Leu Ala Phe Lys Met Glu 
465                 470                 475                 480 


Gly Glu Glu Val Asp Lys Val Phe Gly Lys Gln Asp Glu Glu Phe Phe 
                485                 490                 495     


Phe Gln Gly Pro Glu Trp Arg Lys Glu Lys Glu Gly Arg Ala Asp Glu 
            500                 505                 510         


<210>  124
<211>  1383
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  124
ctcgagctga gcgtgtgctt tctgattctg ttccacggct gtctggccag ccggcaagaa       60

tggcagcagc aagacgagtg ccagatcgac cggctggacg ctctggaacc cgacaaccgg      120

gtggaatacg aggccggcac agtggaagct tgggacccca accacgagca gttcagatgt      180

gccggcgtgg cactcgtgcg gcacaccatc cagccaaacg gactgctgct gccccagtac      240

agcaacgccc cccagctgat ctatgtggtg caaggcgagg gcatgaccgg catcagctat      300

cccggctgcc ccgagacata tcaagcccct cagcaaggca gacagcaagg ccagagcggc      360

cggttccaag accggcacca gaagatccgg cggttcagac ggggcgacat cattgccatt      420

ccagccgggg tggcccactg gtgctacaac gagggcaata gccccgtcgt gaccgtgaca      480

ctgctggacg tgtccaacag ccagaaccag ctggaccgga ccccccggaa gtttcatctg      540

gccggcaacc ccaaggacgt gttccagcaa cagcagcagc accagagccg gggcagaaat      600

ctgttcagcg gcttcgacac cgagctgctg gccgaggctt ttcaagtgga cgagcggctg      660

atcaagcagc tgaagtccga ggacaacaga ggcggcatcg tgaaagtgaa ggacgacgag      720

ctgagagtga tccggcccag cagaagccag agcgagagag gcagcgagag cgaggaagag      780

tctgaggacg agaagcggag atggggccag cgggacaacg gcatcgaaga gacaatctgc      840

accatgcggc tgaaagagaa catcaacgac cccgccagag ccgacatcta cacccccgaa      900

gtgggccggc tgacaactct gaactctctg aatctgccca ttctgaagtg gctgcagctg      960

tccgtggaaa agggggtgct gtacaagaac gctctggtgc tgcctcactg gaatctgaac     1020

agccacagca tcatctacgg ctgcaagggc aagggccaag tccaagtggt ggacaacttc     1080

ggcaacagag tgttcgacgg cgaagtgcgc gagggccaga tgctcgtggt gccccagaat     1140

ttcgccgtcg tgaagcgggc cagagaagaa agattcgagt ggatcagctt caagaccaac     1200

gaccgggcca tgaccagccc tctggccgga agaacatctg tgctgggcgg catgcccgag     1260

gaagtgctgg ctaacgcctt ccagatcagc agagaggacg cccggaagat caagttcaac     1320

aaccagcaga ccacactgac cagcggcgag agcagccacc acatgagaga tgacgccgaa     1380

ttc                                                                   1383


<210>  125
<211>  457
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  125

Leu Ser Val Cys Phe Leu Ile Leu Phe His Gly Cys Leu Ala Ser Arg 
1               5                   10                  15      


Gln Glu Trp Gln Gln Gln Asp Glu Cys Gln Ile Asp Arg Leu Asp Ala 
            20                  25                  30          


Leu Glu Pro Asp Asn Arg Val Glu Tyr Glu Ala Gly Thr Val Glu Ala 
        35                  40                  45              


Trp Asp Pro Asn His Glu Gln Phe Arg Cys Ala Gly Val Ala Leu Val 
    50                  55                  60                  


Arg His Thr Ile Gln Pro Asn Gly Leu Leu Leu Pro Gln Tyr Ser Asn 
65                  70                  75                  80  


Ala Pro Gln Leu Ile Tyr Val Val Gln Gly Glu Gly Met Thr Gly Ile 
                85                  90                  95      


Ser Tyr Pro Gly Cys Pro Glu Thr Tyr Gln Ala Pro Gln Gln Gly Arg 
            100                 105                 110         


Gln Gln Gly Gln Ser Gly Arg Phe Gln Asp Arg His Gln Lys Ile Arg 
        115                 120                 125             


Arg Phe Arg Arg Gly Asp Ile Ile Ala Ile Pro Ala Gly Val Ala His 
    130                 135                 140                 


Trp Cys Tyr Asn Glu Gly Asn Ser Pro Val Val Thr Val Thr Leu Leu 
145                 150                 155                 160 


Asp Val Ser Asn Ser Gln Asn Gln Leu Asp Arg Thr Pro Arg Lys Phe 
                165                 170                 175     


His Leu Ala Gly Asn Pro Lys Asp Val Phe Gln Gln Gln Gln Gln His 
            180                 185                 190         


Gln Ser Arg Gly Arg Asn Leu Phe Ser Gly Phe Asp Thr Glu Leu Leu 
        195                 200                 205             


Ala Glu Ala Phe Gln Val Asp Glu Arg Leu Ile Lys Gln Leu Lys Ser 
    210                 215                 220                 


Glu Asp Asn Arg Gly Gly Ile Val Lys Val Lys Asp Asp Glu Leu Arg 
225                 230                 235                 240 


Val Ile Arg Pro Ser Arg Ser Gln Ser Glu Arg Gly Ser Glu Ser Glu 
                245                 250                 255     


Glu Glu Ser Glu Asp Glu Lys Arg Arg Trp Gly Gln Arg Asp Asn Gly 
            260                 265                 270         


Ile Glu Glu Thr Ile Cys Thr Met Arg Leu Lys Glu Asn Ile Asn Asp 
        275                 280                 285             


Pro Ala Arg Ala Asp Ile Tyr Thr Pro Glu Val Gly Arg Leu Thr Thr 
    290                 295                 300                 


Leu Asn Ser Leu Asn Leu Pro Ile Leu Lys Trp Leu Gln Leu Ser Val 
305                 310                 315                 320 


Glu Lys Gly Val Leu Tyr Lys Asn Ala Leu Val Leu Pro His Trp Asn 
                325                 330                 335     


Leu Asn Ser His Ser Ile Ile Tyr Gly Cys Lys Gly Lys Gly Gln Val 
            340                 345                 350         


Gln Val Val Asp Asn Phe Gly Asn Arg Val Phe Asp Gly Glu Val Arg 
        355                 360                 365             


Glu Gly Gln Met Leu Val Val Pro Gln Asn Phe Ala Val Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Arg Phe Glu Trp Ile Ser Phe Lys Thr Asn Asp Arg 
385                 390                 395                 400 


Ala Met Thr Ser Pro Leu Ala Gly Arg Thr Ser Val Leu Gly Gly Met 
                405                 410                 415     


Pro Glu Glu Val Leu Ala Asn Ala Phe Gln Ile Ser Arg Glu Asp Ala 
            420                 425                 430         


Arg Lys Ile Lys Phe Asn Asn Gln Gln Thr Thr Leu Thr Ser Gly Glu 
        435                 440                 445             


Ser Ser His His Met Arg Asp Asp Ala 
    450                 455         


<210>  126
<211>  366
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  126
ctcgagagca tctaccgggc catcgtggaa gtggaagagg acagcggcag agagcagagc       60

tgccagcggc agttcgagga acagcagcgg ttcagaaact gccagagata cgtgaagcaa      120

gaagtgcaga gaggcggcag atacaaccag agacaagagt ctctgagaga gtgctgccaa      180

gagctgcaag aagtggaccg gcgctgccgg tgccagaatc tggaacagat ggtgcgccag      240

ctgcagcagc aagagcagat caagggcgag gaagtgcgcg agctgtacga gacagccagc      300

gagctgcctc ggatctgcag catcagccca agccaaggct gccagttcca gagcagctac      360

gaattc                                                                 366


<210>  127
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  127

Ser Ile Tyr Arg Ala Ile Val Glu Val Glu Glu Asp Ser Gly Arg Glu 
1               5                   10                  15      


Gln Ser Cys Gln Arg Gln Phe Glu Glu Gln Gln Arg Phe Arg Asn Cys 
            20                  25                  30          


Gln Arg Tyr Val Lys Gln Glu Val Gln Arg Gly Gly Arg Tyr Asn Gln 
        35                  40                  45              


Arg Gln Glu Ser Leu Arg Glu Cys Cys Gln Glu Leu Gln Glu Val Asp 
    50                  55                  60                  


Arg Arg Cys Arg Cys Gln Asn Leu Glu Gln Met Val Arg Gln Leu Gln 
65                  70                  75                  80  


Gln Gln Glu Gln Ile Lys Gly Glu Glu Val Arg Glu Leu Tyr Glu Thr 
                85                  90                  95      


Ala Ser Glu Leu Pro Arg Ile Cys Ser Ile Ser Pro Ser Gln Gly Cys 
            100                 105                 110         


Gln Phe Gln Ser Ser Tyr 
        115             


<210>  128
<211>  3297
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  128
ctcgagctga gcgtgtgctt tctgattctg ttccacggct gtctggccag ccggcaagaa       60

tggcagcagc aagacgagtg ccagatcgac cggctggacg ctctggaacc cgacaaccgg      120

gtggaatacg aggccggcac agtggaagct tgggacccca accacgagca gttcagatgt      180

gccggcgtgg cactcgtgcg gcacaccatc cagccaaacg gactgctgct gccccagtac      240

agcaacgccc cccagctgat ctatgtggtg caaggcgagg gcatgaccgg catcagctat      300

cccggctgcc ccgagacata tcaagcccct cagcaaggca gacagcaagg ccagagcggc      360

cggttccaag accggcacca gaagatccgg cggttcagac ggggcgacat cattgccatt      420

ccagccgggg tggcccactg gtgctacaac gagggcaata gccccgtcgt gaccgtgaca      480

ctgctggacg tgtccaacag ccagaaccag ctggaccgga ccccccggaa gtttcatctg      540

gccggcaacc ccaaggacgt gttccagcaa cagcagcagc accagagccg gggcagaaat      600

ctgttcagcg gcttcgacac cgagctgctg gccgaggctt ttcaagtgga cgagcggctg      660

atcaagcagc tgaagtccga ggacaacaga ggcggcatcg tgaaagtgaa ggacgacgag      720

ctgagagtga tccggcccag cagaagccag agcgagagag gcagcgagag cgaggaagag      780

tctgaggacg agaagcggag atggggccag cgggacaacg gcatcgaaga gacaatctgc      840

accatgcggc tgaaagagaa catcaacgac cccgccagag ccgacatcta cacccccgaa      900

gtgggccggc tgacaactct gaactctctg aatctgccca ttctgaagtg gctgcagctg      960

tccgtggaaa agggggtgct gtacaagaac gctctggtgc tgcctcactg gaatctgaac     1020

agccacagca tcatctacgg ctgcaagggc aagggccaag tccaagtggt ggacaacttc     1080

ggcaacagag tgttcgacgg cgaagtgcgc gagggccaga tgctcgtggt gccccagaat     1140

ttcgccgtcg tgaagcgggc cagagaagaa agattcgagt ggatcagctt caagaccaac     1200

gaccgggcca tgaccagccc tctggccgga agaacatctg tgctgggcgg catgcccgag     1260

gaagtgctgg ctaacgcctt ccagatcagc agagaggacg cccggaagat caagttcaac     1320

aaccagcaga ccacactgac cagcggcgag agcagccacc acatgagaga tgacgccggc     1380

ggagggggca agatcgaccc cgagctgaag cagtgcaagc accagtgcaa agtgcagcgg     1440

cagtacgacg agcagcagaa agaacagtgc gtgaaagagt gcgagaagta ctacaaagag     1500

aagaagggcc gcgagcgcga gcacgaagag gaagaggaag aatggggcac cggcggagtg     1560

gacgagcctt ctacacacga gcccgccgag aaacatctga gccagtgcat gagacagtgc     1620

gaacggcaag agggcggcca gcagaaacag ctgtgccggt tccggtgcca agagcggtac     1680

aagaaagagc ggggccagca caactacaag agagaggacg acgaggacga agatgaggac     1740

gaggctgagg aagaggacga gaacccctac gtgttcgagg atgaggactt caccaccaaa     1800

gtgaaaaccg agcaaggcaa agtggtgctg ctgcccaagt tcacccagaa gtccaagctg     1860

ctgcacgctc tggaaaagta ccggctggcc gttctggtgg ccaaccctca agccttcgtg     1920

gtgcccagcc acatggacgc cgacagcatc ttcttcgtgt cttggggcag aggcaccatc     1980

accaagattc tggaaaacaa gcgcgagagc atcaacgtgc ggcaaggcga catcgtgtcc     2040

atcagcagcg gcaccccctt ctacattgcc aacaacgacg agaacgagaa gctgtatctg     2100

gtgcagtttc tgcggcccgt gaatctgccc ggccactttg aagtgttcca cggacccggc     2160

ggagagaacc ccgagagctt ctacagagcc ttcagctggg aaattctgga agccgctctg     2220

aaaacatcca aggacacact ggaaaagctg ttcgagaagc aagaccaagg gaccatcatg     2280

aaggccagca aagaacagat ccgggccatg agcagaagag gcgagggccc caagatctgg     2340

cccttcaccg aggaaagcac cggcagcttc aagctgttta agaaggaccc cagccagagc     2400

aacaaatacg ggcagctgtt tgaggccgag cggatcgact accccccact ggaaaagctg     2460

gacatggtgg tgtcctacgc caatatcacc aagggcggca tgagcgtgcc cttttacaac     2520

agcagagcca ccaagatcgc catcgtggtg tccggcgagg gctgcgtgga aatcgcttgc     2580

cctcatctga gcagcagcaa gtccagccac cccagctaca agaagctgcg ggccagaatc     2640

cggaaggaca ccgtgttcat cgtgccagcc ggccaccctt ttgccacagt ggccagcggc     2700

aacgagaatc tggaaatcgt gtgcttcgaa gtgaacgccg agggcaacat ccggtacaca     2760

ctggccggca agaagaacat catcaaagtg atggaaaagg aagccaaaga actggccttt     2820

aagatggaag gcgaggaagt ggacaaagtg ttcggcaagc aagatgaaga gttcttcttt     2880

caaggccccg agtggcgcaa agagaaagag ggcagagccg acgagggcgg agggggcagc     2940

atctaccggg ccatcgtgga agtggaagag gacagcggca gagagcagag ctgccagcgg     3000

cagttcgagg aacagcagcg gttcagaaac tgccagagat acgtgaagca agaagtgcag     3060

agaggcggca gatacaacca gagacaagag tctctgagag agtgctgcca agagctgcaa     3120

gaagtggacc ggcgctgccg gtgccagaat ctggaacaga tggtgcgcca gctgcagcag     3180

caagagcaga tcaagggcga ggaagtgcgc gagctgtacg agacagccag cgagctgcct     3240

cggatctgca gcatcagccc aagccaaggc tgccagttcc agagcagcta cgaattc        3297


<210>  129
<211>  1095
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  129

Leu Ser Val Cys Phe Leu Ile Leu Phe His Gly Cys Leu Ala Ser Arg 
1               5                   10                  15      


Gln Glu Trp Gln Gln Gln Asp Glu Cys Gln Ile Asp Arg Leu Asp Ala 
            20                  25                  30          


Leu Glu Pro Asp Asn Arg Val Glu Tyr Glu Ala Gly Thr Val Glu Ala 
        35                  40                  45              


Trp Asp Pro Asn His Glu Gln Phe Arg Cys Ala Gly Val Ala Leu Val 
    50                  55                  60                  


Arg His Thr Ile Gln Pro Asn Gly Leu Leu Leu Pro Gln Tyr Ser Asn 
65                  70                  75                  80  


Ala Pro Gln Leu Ile Tyr Val Val Gln Gly Glu Gly Met Thr Gly Ile 
                85                  90                  95      


Ser Tyr Pro Gly Cys Pro Glu Thr Tyr Gln Ala Pro Gln Gln Gly Arg 
            100                 105                 110         


Gln Gln Gly Gln Ser Gly Arg Phe Gln Asp Arg His Gln Lys Ile Arg 
        115                 120                 125             


Arg Phe Arg Arg Gly Asp Ile Ile Ala Ile Pro Ala Gly Val Ala His 
    130                 135                 140                 


Trp Cys Tyr Asn Glu Gly Asn Ser Pro Val Val Thr Val Thr Leu Leu 
145                 150                 155                 160 


Asp Val Ser Asn Ser Gln Asn Gln Leu Asp Arg Thr Pro Arg Lys Phe 
                165                 170                 175     


His Leu Ala Gly Asn Pro Lys Asp Val Phe Gln Gln Gln Gln Gln His 
            180                 185                 190         


Gln Ser Arg Gly Arg Asn Leu Phe Ser Gly Phe Asp Thr Glu Leu Leu 
        195                 200                 205             


Ala Glu Ala Phe Gln Val Asp Glu Arg Leu Ile Lys Gln Leu Lys Ser 
    210                 215                 220                 


Glu Asp Asn Arg Gly Gly Ile Val Lys Val Lys Asp Asp Glu Leu Arg 
225                 230                 235                 240 


Val Ile Arg Pro Ser Arg Ser Gln Ser Glu Arg Gly Ser Glu Ser Glu 
                245                 250                 255     


Glu Glu Ser Glu Asp Glu Lys Arg Arg Trp Gly Gln Arg Asp Asn Gly 
            260                 265                 270         


Ile Glu Glu Thr Ile Cys Thr Met Arg Leu Lys Glu Asn Ile Asn Asp 
        275                 280                 285             


Pro Ala Arg Ala Asp Ile Tyr Thr Pro Glu Val Gly Arg Leu Thr Thr 
    290                 295                 300                 


Leu Asn Ser Leu Asn Leu Pro Ile Leu Lys Trp Leu Gln Leu Ser Val 
305                 310                 315                 320 


Glu Lys Gly Val Leu Tyr Lys Asn Ala Leu Val Leu Pro His Trp Asn 
                325                 330                 335     


Leu Asn Ser His Ser Ile Ile Tyr Gly Cys Lys Gly Lys Gly Gln Val 
            340                 345                 350         


Gln Val Val Asp Asn Phe Gly Asn Arg Val Phe Asp Gly Glu Val Arg 
        355                 360                 365             


Glu Gly Gln Met Leu Val Val Pro Gln Asn Phe Ala Val Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Arg Phe Glu Trp Ile Ser Phe Lys Thr Asn Asp Arg 
385                 390                 395                 400 


Ala Met Thr Ser Pro Leu Ala Gly Arg Thr Ser Val Leu Gly Gly Met 
                405                 410                 415     


Pro Glu Glu Val Leu Ala Asn Ala Phe Gln Ile Ser Arg Glu Asp Ala 
            420                 425                 430         


Arg Lys Ile Lys Phe Asn Asn Gln Gln Thr Thr Leu Thr Ser Gly Glu 
        435                 440                 445             


Ser Ser His His Met Arg Asp Asp Ala Gly Gly Gly Gly Lys Ile Asp 
    450                 455                 460                 


Pro Glu Leu Lys Gln Cys Lys His Gln Cys Lys Val Gln Arg Gln Tyr 
465                 470                 475                 480 


Asp Glu Gln Gln Lys Glu Gln Cys Val Lys Glu Cys Glu Lys Tyr Tyr 
                485                 490                 495     


Lys Glu Lys Lys Gly Arg Glu Arg Glu His Glu Glu Glu Glu Glu Glu 
            500                 505                 510         


Trp Gly Thr Gly Gly Val Asp Glu Pro Ser Thr His Glu Pro Ala Glu 
        515                 520                 525             


Lys His Leu Ser Gln Cys Met Arg Gln Cys Glu Arg Gln Glu Gly Gly 
    530                 535                 540                 


Gln Gln Lys Gln Leu Cys Arg Phe Arg Cys Gln Glu Arg Tyr Lys Lys 
545                 550                 555                 560 


Glu Arg Gly Gln His Asn Tyr Lys Arg Glu Asp Asp Glu Asp Glu Asp 
                565                 570                 575     


Glu Asp Glu Ala Glu Glu Glu Asp Glu Asn Pro Tyr Val Phe Glu Asp 
            580                 585                 590         


Glu Asp Phe Thr Thr Lys Val Lys Thr Glu Gln Gly Lys Val Val Leu 
        595                 600                 605             


Leu Pro Lys Phe Thr Gln Lys Ser Lys Leu Leu His Ala Leu Glu Lys 
    610                 615                 620                 


Tyr Arg Leu Ala Val Leu Val Ala Asn Pro Gln Ala Phe Val Val Pro 
625                 630                 635                 640 


Ser His Met Asp Ala Asp Ser Ile Phe Phe Val Ser Trp Gly Arg Gly 
                645                 650                 655     


Thr Ile Thr Lys Ile Leu Glu Asn Lys Arg Glu Ser Ile Asn Val Arg 
            660                 665                 670         


Gln Gly Asp Ile Val Ser Ile Ser Ser Gly Thr Pro Phe Tyr Ile Ala 
        675                 680                 685             


Asn Asn Asp Glu Asn Glu Lys Leu Tyr Leu Val Gln Phe Leu Arg Pro 
    690                 695                 700                 


Val Asn Leu Pro Gly His Phe Glu Val Phe His Gly Pro Gly Gly Glu 
705                 710                 715                 720 


Asn Pro Glu Ser Phe Tyr Arg Ala Phe Ser Trp Glu Ile Leu Glu Ala 
                725                 730                 735     


Ala Leu Lys Thr Ser Lys Asp Thr Leu Glu Lys Leu Phe Glu Lys Gln 
            740                 745                 750         


Asp Gln Gly Thr Ile Met Lys Ala Ser Lys Glu Gln Ile Arg Ala Met 
        755                 760                 765             


Ser Arg Arg Gly Glu Gly Pro Lys Ile Trp Pro Phe Thr Glu Glu Ser 
    770                 775                 780                 


Thr Gly Ser Phe Lys Leu Phe Lys Lys Asp Pro Ser Gln Ser Asn Lys 
785                 790                 795                 800 


Tyr Gly Gln Leu Phe Glu Ala Glu Arg Ile Asp Tyr Pro Pro Leu Glu 
                805                 810                 815     


Lys Leu Asp Met Val Val Ser Tyr Ala Asn Ile Thr Lys Gly Gly Met 
            820                 825                 830         


Ser Val Pro Phe Tyr Asn Ser Arg Ala Thr Lys Ile Ala Ile Val Val 
        835                 840                 845             


Ser Gly Glu Gly Cys Val Glu Ile Ala Cys Pro His Leu Ser Ser Ser 
    850                 855                 860                 


Lys Ser Ser His Pro Ser Tyr Lys Lys Leu Arg Ala Arg Ile Arg Lys 
865                 870                 875                 880 


Asp Thr Val Phe Ile Val Pro Ala Gly His Pro Phe Ala Thr Val Ala 
                885                 890                 895     


Ser Gly Asn Glu Asn Leu Glu Ile Val Cys Phe Glu Val Asn Ala Glu 
            900                 905                 910         


Gly Asn Ile Arg Tyr Thr Leu Ala Gly Lys Lys Asn Ile Ile Lys Val 
        915                 920                 925             


Met Glu Lys Glu Ala Lys Glu Leu Ala Phe Lys Met Glu Gly Glu Glu 
    930                 935                 940                 


Val Asp Lys Val Phe Gly Lys Gln Asp Glu Glu Phe Phe Phe Gln Gly 
945                 950                 955                 960 


Pro Glu Trp Arg Lys Glu Lys Glu Gly Arg Ala Asp Glu Gly Gly Gly 
                965                 970                 975     


Gly Ser Ile Tyr Arg Ala Ile Val Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Glu Gln Ser Cys Gln Arg Gln Phe  Glu Glu Gln Gln Arg  Phe Arg Asn 
        995                 1000                 1005             


Cys Gln  Arg Tyr Val Lys Gln  Glu Val Gln Arg Gly  Gly Arg Tyr 
    1010                 1015                 1020             


Asn Gln  Arg Gln Glu Ser Leu  Arg Glu Cys Cys Gln  Glu Leu Gln 
    1025                 1030                 1035             


Glu Val  Asp Arg Arg Cys Arg  Cys Gln Asn Leu Glu  Gln Met Val 
    1040                 1045                 1050             


Arg Gln  Leu Gln Gln Gln Glu  Gln Ile Lys Gly Glu  Glu Val Arg 
    1055                 1060                 1065             


Glu Leu  Tyr Glu Thr Ala Ser  Glu Leu Pro Arg Ile  Cys Ser Ile 
    1070                 1075                 1080             


Ser Pro  Ser Gln Gly Cys Gln  Phe Gln Ser Ser Tyr  
    1085                 1090                 1095 


<210>  130
<211>  381
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  130
ctcgagcgga ccaccatcac caccatggaa atcgacgagg acatcgacaa ccccagaaga       60

agaggcgagg gctgccaaga gcagatccag cggcagcaga atctgaacca ctgccagtac      120

tatctgaggc agcagagcag aagcggcggc tacgacgagg ataaccagag acagcacttc      180

agacagtgct gccagcagct gagccagatc gaggaacagt gccagtgcga gggactgaga      240

caagccgtgc ggagacaaca gcagcagcaa ggactgcggg gcgaagagat ggaagaaatg      300

gtgcagagcg ccagagatct gcccaaagag tgcggcatca gcagccagag atgcgagatc      360

cggcggagtt ggttcgaatt c                                                381


<210>  131
<211>  123
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  131

Arg Thr Thr Ile Thr Thr Met Glu Ile Asp Glu Asp Ile Asp Asn Pro 
1               5                   10                  15      


Arg Arg Arg Gly Glu Gly Cys Gln Glu Gln Ile Gln Arg Gln Gln Asn 
            20                  25                  30          


Leu Asn His Cys Gln Tyr Tyr Leu Arg Gln Gln Ser Arg Ser Gly Gly 
        35                  40                  45              


Tyr Asp Glu Asp Asn Gln Arg Gln His Phe Arg Gln Cys Cys Gln Gln 
    50                  55                  60                  


Leu Ser Gln Ile Glu Glu Gln Cys Gln Cys Glu Gly Leu Arg Gln Ala 
65                  70                  75                  80  


Val Arg Arg Gln Gln Gln Gln Gln Gly Leu Arg Gly Glu Glu Met Glu 
                85                  90                  95      


Glu Met Val Gln Ser Ala Arg Asp Leu Pro Lys Glu Cys Gly Ile Ser 
            100                 105                 110         


Ser Gln Arg Cys Glu Ile Arg Arg Ser Trp Phe 
        115                 120             


<210>  132
<211>  1791
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  132
ctcgagagag gccgggacga cgacgatgag gaaaacccca gagatccccg cgagcagtac       60

cggcagtgcc aagagtactg cagaaggcaa ggccaaggcc agagacagca gcagcagtgc      120

cagatcagat gcgaggaacg gctggaagag gaccagcgga gccaagagga acgcgagcgg      180

agaagaggca gagatgtgga cgaccagaac ccccgggacc ccgagcagag atacgagcag      240

tgtcagcagc agtgtgaacg gcagcggaga ggccaagagc agacactgtg tcggcggaga      300

tgcgagcagc ggcggcagca agaggaaaga gaacgccagc ggggcagaga cagacaagac      360

ccccagcagc agtaccaccg gtgccagaga agatgccaga tccaagaaca gagccccgag      420

cggcagcgcc agtgccagca gagatgcgaa agacagtaca aagagcagca aggcagagag      480

aggggcccag aggccagccc tagaagagag tccagaggac gggaagaaga acagcagcgg      540

cacaacccct actacttcca cagccagagc atcagaagcc ggcacgagag cgaagagggc      600

gaagtgaagt atctggaacg gttcaccgag cggaccgagc tgctgagagg catcgagaac      660

taccgggtcg tgattctgga cgccaacccc aacacatcca tgctgcccca ccacaaggac      720

gccgagtctg tggccgtcgt gacaaggggc agagccacac tgacactggt gtcccaagag      780

actcgcgaga gcttcaatct ggaatgcggc gacgtgatcc gggtgccagc tggggctaca      840

gtgtacgtga tcaaccaaga cagcaacgag cggctggaaa tggtcaagct gctgcagccc      900

gtgaacaacc ccggccagtt cagagagtac tacgccgctg gcgccaagtc ccccgaccag      960

agctatctgc gggtgttcag caacgacatt ctggtggccg ctctgaatac ccctcgggac     1020

agactggaaa gattcttcga tcagcaagag cagcgcgagg gcgtgatcat cagagccagc     1080

caagagaagc tgcgggctct gagccagcac gccatgtctg ctggacagag gccttggggc     1140

agaagaagct ctggcggccc tatctctctg aagtccgaga gcccctccta cagcaaccag     1200

tttggccagt tcttcgaggc ttgccccgag gaacaccggc agctgcaaga aatggacgtg     1260

ctcgtgaact acgccgagat caagaggggc gccatgatgg tgccccacta caacagcaag     1320

gccaccgtgg tggtgtacgt ggtggaaggc accggcagat acgagatggc atgcccccac     1380

gtgtccagcc agtcttacga gggccaagga cgcagagagc aagaagagga agagtccacc     1440

ggacggttcc agaaagtgac cgccagactg gccagaggcg acatcttcgt gatcccagcc     1500

ggacacccta tcgccatcac cgccagccag aacgagaatc tgcggctgct gggcttcgac     1560

atcaacggcg agaacaacca gcgggacttt ctggccggac agaacaacat catcaaccag     1620

ctggaacggg aagccaaaga actgagcttc aacatgcccc gcgaggaaat cgaagagatt     1680

ttcgagagcc agatggaaag ctacttcgtg cccaccgagc gccagagcag aaggggccaa     1740

gggcgggatc acccactggc ctctattctg gatttcgcct tcttcgaatt c              1791


<210>  133
<211>  593
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  133

Arg Gly Arg Asp Asp Asp Asp Glu Glu Asn Pro Arg Asp Pro Arg Glu 
1               5                   10                  15      


Gln Tyr Arg Gln Cys Gln Glu Tyr Cys Arg Arg Gln Gly Gln Gly Gln 
            20                  25                  30          


Arg Gln Gln Gln Gln Cys Gln Ile Arg Cys Glu Glu Arg Leu Glu Glu 
        35                  40                  45              


Asp Gln Arg Ser Gln Glu Glu Arg Glu Arg Arg Arg Gly Arg Asp Val 
    50                  55                  60                  


Asp Asp Gln Asn Pro Arg Asp Pro Glu Gln Arg Tyr Glu Gln Cys Gln 
65                  70                  75                  80  


Gln Gln Cys Glu Arg Gln Arg Arg Gly Gln Glu Gln Thr Leu Cys Arg 
                85                  90                  95      


Arg Arg Cys Glu Gln Arg Arg Gln Gln Glu Glu Arg Glu Arg Gln Arg 
            100                 105                 110         


Gly Arg Asp Arg Gln Asp Pro Gln Gln Gln Tyr His Arg Cys Gln Arg 
        115                 120                 125             


Arg Cys Gln Ile Gln Glu Gln Ser Pro Glu Arg Gln Arg Gln Cys Gln 
    130                 135                 140                 


Gln Arg Cys Glu Arg Gln Tyr Lys Glu Gln Gln Gly Arg Glu Arg Gly 
145                 150                 155                 160 


Pro Glu Ala Ser Pro Arg Arg Glu Ser Arg Gly Arg Glu Glu Glu Gln 
                165                 170                 175     


Gln Arg His Asn Pro Tyr Tyr Phe His Ser Gln Ser Ile Arg Ser Arg 
            180                 185                 190         


His Glu Ser Glu Glu Gly Glu Val Lys Tyr Leu Glu Arg Phe Thr Glu 
        195                 200                 205             


Arg Thr Glu Leu Leu Arg Gly Ile Glu Asn Tyr Arg Val Val Ile Leu 
    210                 215                 220                 


Asp Ala Asn Pro Asn Thr Ser Met Leu Pro His His Lys Asp Ala Glu 
225                 230                 235                 240 


Ser Val Ala Val Val Thr Arg Gly Arg Ala Thr Leu Thr Leu Val Ser 
                245                 250                 255     


Gln Glu Thr Arg Glu Ser Phe Asn Leu Glu Cys Gly Asp Val Ile Arg 
            260                 265                 270         


Val Pro Ala Gly Ala Thr Val Tyr Val Ile Asn Gln Asp Ser Asn Glu 
        275                 280                 285             


Arg Leu Glu Met Val Lys Leu Leu Gln Pro Val Asn Asn Pro Gly Gln 
    290                 295                 300                 


Phe Arg Glu Tyr Tyr Ala Ala Gly Ala Lys Ser Pro Asp Gln Ser Tyr 
305                 310                 315                 320 


Leu Arg Val Phe Ser Asn Asp Ile Leu Val Ala Ala Leu Asn Thr Pro 
                325                 330                 335     


Arg Asp Arg Leu Glu Arg Phe Phe Asp Gln Gln Glu Gln Arg Glu Gly 
            340                 345                 350         


Val Ile Ile Arg Ala Ser Gln Glu Lys Leu Arg Ala Leu Ser Gln His 
        355                 360                 365             


Ala Met Ser Ala Gly Gln Arg Pro Trp Gly Arg Arg Ser Ser Gly Gly 
    370                 375                 380                 


Pro Ile Ser Leu Lys Ser Glu Ser Pro Ser Tyr Ser Asn Gln Phe Gly 
385                 390                 395                 400 


Gln Phe Phe Glu Ala Cys Pro Glu Glu His Arg Gln Leu Gln Glu Met 
                405                 410                 415     


Asp Val Leu Val Asn Tyr Ala Glu Ile Lys Arg Gly Ala Met Met Val 
            420                 425                 430         


Pro His Tyr Asn Ser Lys Ala Thr Val Val Val Tyr Val Val Glu Gly 
        435                 440                 445             


Thr Gly Arg Tyr Glu Met Ala Cys Pro His Val Ser Ser Gln Ser Tyr 
    450                 455                 460                 


Glu Gly Gln Gly Arg Arg Glu Gln Glu Glu Glu Glu Ser Thr Gly Arg 
465                 470                 475                 480 


Phe Gln Lys Val Thr Ala Arg Leu Ala Arg Gly Asp Ile Phe Val Ile 
                485                 490                 495     


Pro Ala Gly His Pro Ile Ala Ile Thr Ala Ser Gln Asn Glu Asn Leu 
            500                 505                 510         


Arg Leu Leu Gly Phe Asp Ile Asn Gly Glu Asn Asn Gln Arg Asp Phe 
        515                 520                 525             


Leu Ala Gly Gln Asn Asn Ile Ile Asn Gln Leu Glu Arg Glu Ala Lys 
    530                 535                 540                 


Glu Leu Ser Phe Asn Met Pro Arg Glu Glu Ile Glu Glu Ile Phe Glu 
545                 550                 555                 560 


Ser Gln Met Glu Ser Tyr Phe Val Pro Thr Glu Arg Gln Ser Arg Arg 
                565                 570                 575     


Gly Gln Gly Arg Asp His Pro Leu Ala Ser Ile Leu Asp Phe Ala Phe 
            580                 585                 590         


Phe 
    


<210>  134
<211>  2172
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  134
ctcgagcgga ccaccatcac caccatggaa atcgacgagg acatcgacaa ccccagaaga       60

agaggcgagg gctgccaaga gcagatccag cggcagcaga atctgaacca ctgccagtac      120

tatctgaggc agcagagcag aagcggcggc tacgacgagg ataaccagag acagcacttc      180

agacagtgct gccagcagct gagccagatc gaggaacagt gccagtgcga gggactgaga      240

caagccgtgc ggagacaaca gcagcagcaa ggactgcggg gcgaagagat ggaagaaatg      300

gtgcagagcg ccagagatct gcccaaagag tgcggcatca gcagccagag atgcgagatc      360

cggcggagtt ggttcggcgg agggggcaga ggccgggacg acgacgatga ggaaaacccc      420

agagatcccc gcgagcagta ccggcagtgc caagagtact gcagaaggca aggccaaggc      480

cagagacagc agcagcagtg ccagatcaga tgcgaggaac ggctggaaga ggaccagcgg      540

agccaagagg aacgcgagcg gagaagaggc agagatgtgg acgaccagaa cccccgggac      600

cccgagcaga gatacgagca gtgtcagcag cagtgtgaac ggcagcggag aggccaagag      660

cagacactgt gtcggcggag atgcgagcag cggcggcagc aagaggaaag agaacgccag      720

cggggcagag acagacaaga cccccagcag cagtaccacc ggtgccagag aagatgccag      780

atccaagaac agagccccga gcggcagcgc cagtgccagc agagatgcga aagacagtac      840

aaagagcagc aaggcagaga gaggggccca gaggccagcc ctagaagaga gtccagagga      900

cgggaagaag aacagcagcg gcacaacccc tactacttcc acagccagag catcagaagc      960

cggcacgaga gcgaagaggg cgaagtgaag tatctggaac ggttcaccga gcggaccgag     1020

ctgctgagag gcatcgagaa ctaccgggtc gtgattctgg acgccaaccc caacacatcc     1080

atgctgcccc accacaagga cgccgagtct gtggccgtcg tgacaagggg cagagccaca     1140

ctgacactgg tgtcccaaga gactcgcgag agcttcaatc tggaatgcgg cgacgtgatc     1200

cgggtgccag ctggggctac agtgtacgtg atcaaccaag acagcaacga gcggctggaa     1260

atggtcaagc tgctgcagcc cgtgaacaac cccggccagt tcagagagta ctacgccgct     1320

ggcgccaagt cccccgacca gagctatctg cgggtgttca gcaacgacat tctggtggcc     1380

gctctgaata cccctcggga cagactggaa agattcttcg atcagcaaga gcagcgcgag     1440

ggcgtgatca tcagagccag ccaagagaag ctgcgggctc tgagccagca cgccatgtct     1500

gctggacaga ggccttgggg cagaagaagc tctggcggcc ctatctctct gaagtccgag     1560

agcccctcct acagcaacca gtttggccag ttcttcgagg cttgccccga ggaacaccgg     1620

cagctgcaag aaatggacgt gctcgtgaac tacgccgaga tcaagagggg cgccatgatg     1680

gtgccccact acaacagcaa ggccaccgtg gtggtgtacg tggtggaagg caccggcaga     1740

tacgagatgg catgccccca cgtgtccagc cagtcttacg agggccaagg acgcagagag     1800

caagaagagg aagagtccac cggacggttc cagaaagtga ccgccagact ggccagaggc     1860

gacatcttcg tgatcccagc cggacaccct atcgccatca ccgccagcca gaacgagaat     1920

ctgcggctgc tgggcttcga catcaacggc gagaacaacc agcgggactt tctggccgga     1980

cagaacaaca tcatcaacca gctggaacgg gaagccaaag aactgagctt caacatgccc     2040

cgcgaggaaa tcgaagagat tttcgagagc cagatggaaa gctacttcgt gcccaccgag     2100

cgccagagca gaaggggcca agggcgggat cacccactgg cctctattct ggatttcgcc     2160

ttcttcgaat tc                                                         2172


<210>  135
<211>  720
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  135

Arg Thr Thr Ile Thr Thr Met Glu Ile Asp Glu Asp Ile Asp Asn Pro 
1               5                   10                  15      


Arg Arg Arg Gly Glu Gly Cys Gln Glu Gln Ile Gln Arg Gln Gln Asn 
            20                  25                  30          


Leu Asn His Cys Gln Tyr Tyr Leu Arg Gln Gln Ser Arg Ser Gly Gly 
        35                  40                  45              


Tyr Asp Glu Asp Asn Gln Arg Gln His Phe Arg Gln Cys Cys Gln Gln 
    50                  55                  60                  


Leu Ser Gln Ile Glu Glu Gln Cys Gln Cys Glu Gly Leu Arg Gln Ala 
65                  70                  75                  80  


Val Arg Arg Gln Gln Gln Gln Gln Gly Leu Arg Gly Glu Glu Met Glu 
                85                  90                  95      


Glu Met Val Gln Ser Ala Arg Asp Leu Pro Lys Glu Cys Gly Ile Ser 
            100                 105                 110         


Ser Gln Arg Cys Glu Ile Arg Arg Ser Trp Phe Gly Gly Gly Gly Arg 
        115                 120                 125             


Gly Arg Asp Asp Asp Asp Glu Glu Asn Pro Arg Asp Pro Arg Glu Gln 
    130                 135                 140                 


Tyr Arg Gln Cys Gln Glu Tyr Cys Arg Arg Gln Gly Gln Gly Gln Arg 
145                 150                 155                 160 


Gln Gln Gln Gln Cys Gln Ile Arg Cys Glu Glu Arg Leu Glu Glu Asp 
                165                 170                 175     


Gln Arg Ser Gln Glu Glu Arg Glu Arg Arg Arg Gly Arg Asp Val Asp 
            180                 185                 190         


Asp Gln Asn Pro Arg Asp Pro Glu Gln Arg Tyr Glu Gln Cys Gln Gln 
        195                 200                 205             


Gln Cys Glu Arg Gln Arg Arg Gly Gln Glu Gln Thr Leu Cys Arg Arg 
    210                 215                 220                 


Arg Cys Glu Gln Arg Arg Gln Gln Glu Glu Arg Glu Arg Gln Arg Gly 
225                 230                 235                 240 


Arg Asp Arg Gln Asp Pro Gln Gln Gln Tyr His Arg Cys Gln Arg Arg 
                245                 250                 255     


Cys Gln Ile Gln Glu Gln Ser Pro Glu Arg Gln Arg Gln Cys Gln Gln 
            260                 265                 270         


Arg Cys Glu Arg Gln Tyr Lys Glu Gln Gln Gly Arg Glu Arg Gly Pro 
        275                 280                 285             


Glu Ala Ser Pro Arg Arg Glu Ser Arg Gly Arg Glu Glu Glu Gln Gln 
    290                 295                 300                 


Arg His Asn Pro Tyr Tyr Phe His Ser Gln Ser Ile Arg Ser Arg His 
305                 310                 315                 320 


Glu Ser Glu Glu Gly Glu Val Lys Tyr Leu Glu Arg Phe Thr Glu Arg 
                325                 330                 335     


Thr Glu Leu Leu Arg Gly Ile Glu Asn Tyr Arg Val Val Ile Leu Asp 
            340                 345                 350         


Ala Asn Pro Asn Thr Ser Met Leu Pro His His Lys Asp Ala Glu Ser 
        355                 360                 365             


Val Ala Val Val Thr Arg Gly Arg Ala Thr Leu Thr Leu Val Ser Gln 
    370                 375                 380                 


Glu Thr Arg Glu Ser Phe Asn Leu Glu Cys Gly Asp Val Ile Arg Val 
385                 390                 395                 400 


Pro Ala Gly Ala Thr Val Tyr Val Ile Asn Gln Asp Ser Asn Glu Arg 
                405                 410                 415     


Leu Glu Met Val Lys Leu Leu Gln Pro Val Asn Asn Pro Gly Gln Phe 
            420                 425                 430         


Arg Glu Tyr Tyr Ala Ala Gly Ala Lys Ser Pro Asp Gln Ser Tyr Leu 
        435                 440                 445             


Arg Val Phe Ser Asn Asp Ile Leu Val Ala Ala Leu Asn Thr Pro Arg 
    450                 455                 460                 


Asp Arg Leu Glu Arg Phe Phe Asp Gln Gln Glu Gln Arg Glu Gly Val 
465                 470                 475                 480 


Ile Ile Arg Ala Ser Gln Glu Lys Leu Arg Ala Leu Ser Gln His Ala 
                485                 490                 495     


Met Ser Ala Gly Gln Arg Pro Trp Gly Arg Arg Ser Ser Gly Gly Pro 
            500                 505                 510         


Ile Ser Leu Lys Ser Glu Ser Pro Ser Tyr Ser Asn Gln Phe Gly Gln 
        515                 520                 525             


Phe Phe Glu Ala Cys Pro Glu Glu His Arg Gln Leu Gln Glu Met Asp 
    530                 535                 540                 


Val Leu Val Asn Tyr Ala Glu Ile Lys Arg Gly Ala Met Met Val Pro 
545                 550                 555                 560 


His Tyr Asn Ser Lys Ala Thr Val Val Val Tyr Val Val Glu Gly Thr 
                565                 570                 575     


Gly Arg Tyr Glu Met Ala Cys Pro His Val Ser Ser Gln Ser Tyr Glu 
            580                 585                 590         


Gly Gln Gly Arg Arg Glu Gln Glu Glu Glu Glu Ser Thr Gly Arg Phe 
        595                 600                 605             


Gln Lys Val Thr Ala Arg Leu Ala Arg Gly Asp Ile Phe Val Ile Pro 
    610                 615                 620                 


Ala Gly His Pro Ile Ala Ile Thr Ala Ser Gln Asn Glu Asn Leu Arg 
625                 630                 635                 640 


Leu Leu Gly Phe Asp Ile Asn Gly Glu Asn Asn Gln Arg Asp Phe Leu 
                645                 650                 655     


Ala Gly Gln Asn Asn Ile Ile Asn Gln Leu Glu Arg Glu Ala Lys Glu 
            660                 665                 670         


Leu Ser Phe Asn Met Pro Arg Glu Glu Ile Glu Glu Ile Phe Glu Ser 
        675                 680                 685             


Gln Met Glu Ser Tyr Phe Val Pro Thr Glu Arg Gln Ser Arg Arg Gly 
    690                 695                 700                 


Gln Gly Arg Asp His Pro Leu Ala Ser Ile Leu Asp Phe Ala Phe Phe 
705                 710                 715                 720 


<210>  136

<400>  136
000

<210>  137
<211>  371
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  137

Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu 
1               5                   10                  15      


Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys Trp Arg Gly Lys 
            20                  25                  30          


Ala Asp Trp Ala Glu Asn Arg Lys Ala Leu Ala Asp Cys Ala Gln Gly 
        35                  40                  45              


Phe Gly Lys Gly Thr Val Gly Gly Lys Asp Gly Asp Ile Tyr Thr Val 
    50                  55                  60                  


Thr Ser Glu Leu Asp Asp Asp Val Ala Asn Pro Lys Glu Gly Thr Leu 
65                  70                  75                  80  


Arg Phe Gly Ala Ala Gln Asn Arg Pro Leu Trp Ile Ile Phe Glu Arg 
                85                  90                  95      


Asp Met Val Ile Arg Leu Asp Lys Glu Met Val Val Asn Ser Asp Lys 
            100                 105                 110         


Thr Ile Asp Gly Arg Gly Ala Lys Val Glu Ile Ile Asn Ala Gly Phe 
        115                 120                 125             


Thr Leu Asn Gly Val Lys Asn Val Ile Ile His Asn Ile Asn Met His 
    130                 135                 140                 


Asp Val Lys Val Asn Pro Gly Gly Leu Ile Lys Ser Asn Asp Gly Pro 
145                 150                 155                 160 


Ala Ala Pro Arg Ala Gly Ser Asp Gly Asp Ala Ile Ser Ile Ser Gly 
                165                 170                 175     


Ser Ser Gln Ile Trp Ile Asp His Cys Ser Leu Ser Lys Ser Val Asp 
            180                 185                 190         


Gly Leu Val Asp Ala Lys Leu Gly Thr Thr Arg Leu Thr Val Ser Asn 
        195                 200                 205             


Ser Leu Phe Thr Gln His Gln Phe Val Leu Leu Phe Gly Ala Gly Asp 
    210                 215                 220                 


Glu Asn Ile Glu Asp Arg Gly Met Leu Ala Thr Val Ala Phe Asn Thr 
225                 230                 235                 240 


Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg Cys Arg His Gly Phe 
                245                 250                 255     


Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile 
            260                 265                 270         


Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Gln Gly Asn Arg Phe Cys 
        275                 280                 285             


Ala Pro Asp Glu Arg Ser Lys Lys Asn Val Leu Gly Arg His Gly Glu 
    290                 295                 300                 


Ala Ala Ala Glu Ser Met Lys Trp Asn Trp Arg Thr Asn Lys Asp Val 
305                 310                 315                 320 


Leu Glu Asn Gly Ala Ile Phe Val Ala Ser Gly Val Asp Pro Val Leu 
                325                 330                 335     


Thr Pro Glu Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser 
            340                 345                 350         


Ala Leu Ser Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Gln Pro Gly 
        355                 360                 365             


Ala Pro Cys 
    370     


<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141
<211>  159
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  141

Gly Val Phe Asn Tyr Glu Thr Glu Thr Thr Ser Val Ile Pro Ala Ala 
1               5                   10                  15      


Arg Leu Phe Lys Ala Phe Ile Leu Asp Gly Asp Asn Leu Phe Pro Lys 
            20                  25                  30          


Val Ala Pro Gln Ala Ile Ser Ser Val Glu Asn Ile Glu Gly Asn Gly 
        35                  40                  45              


Gly Pro Gly Thr Ile Lys Lys Ile Ser Phe Pro Glu Gly Phe Pro Phe 
    50                  55                  60                  


Lys Tyr Val Lys Asp Arg Val Asp Glu Val Asp His Thr Asn Phe Lys 
65                  70                  75                  80  


Tyr Asn Tyr Ser Val Ile Glu Gly Gly Pro Ile Gly Asp Thr Leu Glu 
                85                  90                  95      


Lys Ile Ser Asn Glu Ile Lys Ile Val Ala Thr Pro Asp Gly Gly Ser 
            100                 105                 110         


Ile Leu Lys Ile Ser Asn Lys Tyr His Thr Lys Gly Asp His Glu Val 
        115                 120                 125             


Lys Ala Glu Gln Val Lys Ala Ser Lys Glu Met Gly Glu Thr Leu Leu 
    130                 135                 140                 


Arg Ala Val Glu Ser Tyr Leu Leu Ala His Ser Asp Ala Tyr Asn 
145                 150                 155                 


<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145
<211>  156
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  145

Gln Asp Thr Pro Ala Leu Gly Lys Asp Thr Val Ala Val Ser Gly Lys 
1               5                   10                  15      


Trp Tyr Leu Lys Ala Met Thr Ala Asp Gln Glu Val Pro Glu Lys Pro 
            20                  25                  30          


Asp Ser Val Thr Pro Met Ile Leu Lys Ala Gln Lys Gly Gly Asn Leu 
        35                  40                  45              


Glu Ala Lys Ile Thr Met Leu Thr Asn Gly Gln Cys Gln Asn Ile Thr 
    50                  55                  60                  


Val Val Leu His Lys Thr Ser Glu Pro Gly Lys Tyr Thr Ala Tyr Glu 
65                  70                  75                  80  


Gly Gln Arg Val Val Phe Ile Gln Pro Ser Pro Val Arg Asp His Tyr 
                85                  90                  95      


Ile Leu Tyr Cys Glu Gly Glu Leu His Gly Arg Gln Ile Arg Met Ala 
            100                 105                 110         


Lys Leu Leu Gly Arg Asp Pro Glu Gln Ser Gln Glu Ala Leu Glu Asp 
        115                 120                 125             


Phe Arg Glu Phe Ser Arg Ala Lys Gly Leu Asn Gln Glu Ile Leu Glu 
    130                 135                 140                 


Leu Ala Gln Ser Glu Thr Cys Ser Pro Gly Gly Gln 
145                 150                 155     


<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149
<211>  246
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  149

Ala Ile Gly Asp Lys Pro Gly Pro Asn Ile Thr Ala Thr Tyr Gly Ser 
1               5                   10                  15      


Lys Trp Leu Glu Ala Arg Ala Thr Phe Tyr Gly Ser Asn Pro Arg Gly 
            20                  25                  30          


Ala Ala Pro Asp Asp His Gly Gly Ala Cys Gly Tyr Lys Asp Val Asp 
        35                  40                  45              


Lys Pro Pro Phe Asp Gly Met Thr Ala Cys Gly Asn Glu Pro Ile Phe 
    50                  55                  60                  


Lys Asp Gly Leu Gly Cys Arg Ala Cys Tyr Glu Ile Lys Cys Lys Glu 
65                  70                  75                  80  


Pro Val Glu Cys Ser Gly Glu Pro Val Leu Val Lys Ile Thr Asp Lys 
                85                  90                  95      


Asn Tyr Glu His Ile Ala Ala Tyr His Phe Asp Leu Ser Gly Lys Ala 
            100                 105                 110         


Phe Gly Ala Met Ala Lys Lys Gly Gln Glu Asp Lys Leu Arg Lys Ala 
        115                 120                 125             


Gly Glu Leu Thr Leu Gln Phe Arg Arg Val Lys Cys Lys Tyr Pro Ser 
    130                 135                 140                 


Gly Thr Lys Ile Thr Phe His Ile Glu Lys Gly Ser Asn Asp His Tyr 
145                 150                 155                 160 


Leu Ala Leu Leu Val Lys Tyr Ala Ala Gly Asp Gly Asn Ile Val Ala 
                165                 170                 175     


Val Asp Ile Lys Pro Arg Asp Ser Asp Glu Phe Ile Pro Met Lys Ser 
            180                 185                 190         


Ser Trp Gly Ala Ile Trp Arg Ile Asp Pro Lys Lys Pro Leu Lys Gly 
        195                 200                 205             


Pro Phe Ser Ile Arg Leu Thr Ser Glu Gly Gly Ala His Leu Val Gln 
    210                 215                 220                 


Asp Asp Val Ile Pro Ala Asn Trp Lys Pro Asp Thr Val Tyr Thr Ser 
225                 230                 235                 240 


Lys Leu Gln Phe Gly Ala 
                245     


<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153
<211>  303
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  153

Arg Pro Ala Ser Ile Lys Thr Phe Glu Glu Phe Lys Lys Ala Phe Asn 
1               5                   10                  15      


Lys Asn Tyr Ala Thr Val Glu Glu Glu Glu Val Ala Arg Lys Asn Phe 
            20                  25                  30          


Leu Glu Ser Leu Lys Tyr Val Glu Ala Asn Lys Gly Ala Ile Asn His 
        35                  40                  45              


Leu Ser Asp Leu Ser Leu Asp Glu Phe Lys Asn Arg Tyr Leu Met Ser 
    50                  55                  60                  


Ala Glu Ala Phe Glu Gln Leu Lys Thr Gln Phe Asp Leu Asn Ala Glu 
65                  70                  75                  80  


Thr Ser Ala Cys Arg Ile Asn Ser Val Asn Val Pro Ser Glu Leu Asp 
                85                  90                  95      


Leu Arg Ser Leu Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly Cys 
            100                 105                 110         


Gly Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala Tyr 
        115                 120                 125             


Leu Ala Tyr Arg Asn Thr Ser Leu Asp Leu Ser Glu Gln Glu Leu Val 
    130                 135                 140                 


Asp Cys Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg Gly 
145                 150                 155                 160 


Ile Glu Tyr Ile Gln Gln Asn Gly Val Val Glu Glu Arg Ser Tyr Pro 
                165                 170                 175     


Tyr Val Ala Arg Glu Gln Arg Cys Arg Arg Pro Asn Ser Gln His Tyr 
            180                 185                 190         


Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asp Val Lys Gln Ile 
        195                 200                 205             


Arg Glu Ala Leu Thr Gln Thr His Thr Ala Ile Ala Val Ile Ile Gly 
    210                 215                 220                 


Ile Lys Asp Leu Arg Ala Phe Gln His Tyr Asp Gly Arg Thr Ile Ile 
225                 230                 235                 240 


Gln His Asp Asn Gly Tyr Gln Pro Asn Tyr His Ala Val Asn Ile Val 
                245                 250                 255     


Gly Tyr Gly Ser Thr Gln Gly Asp Asp Tyr Trp Ile Val Arg Asn Ser 
            260                 265                 270         


Trp Asp Thr Thr Trp Gly Asp Ser Gly Tyr Gly Tyr Phe Gln Ala Gly 
        275                 280                 285             


Asn Asn Leu Met Met Ile Glu Gln Tyr Pro Tyr Val Val Ile Met 
    290                 295                 300             


<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157
<211>  223
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  157

Thr Ser Ala Cys Arg Ile Asn Ser Val Asn Val Pro Ser Glu Leu Asp 
1               5                   10                  15      


Leu Arg Ser Leu Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly Cys 
            20                  25                  30          


Gly Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala Tyr 
        35                  40                  45              


Leu Ala Tyr Arg Asn Thr Ser Leu Asp Leu Ser Glu Gln Glu Leu Val 
    50                  55                  60                  


Asp Cys Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg Gly 
65                  70                  75                  80  


Ile Glu Tyr Ile Gln Gln Asn Gly Val Val Glu Glu Arg Ser Tyr Pro 
                85                  90                  95      


Tyr Val Ala Arg Glu Gln Arg Cys Arg Arg Pro Asn Ser Gln His Tyr 
            100                 105                 110         


Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asp Val Lys Gln Ile 
        115                 120                 125             


Arg Glu Ala Leu Thr Gln Thr His Thr Ala Ile Ala Val Ile Ile Gly 
    130                 135                 140                 


Ile Lys Asp Leu Arg Ala Phe Gln His Tyr Asp Gly Arg Thr Ile Ile 
145                 150                 155                 160 


Gln His Asp Asn Gly Tyr Gln Pro Asn Tyr His Ala Val Asn Ile Val 
                165                 170                 175     


Gly Tyr Gly Ser Thr Gln Gly Asp Asp Tyr Trp Ile Val Arg Asn Ser 
            180                 185                 190         


Trp Asp Thr Thr Trp Gly Asp Ser Gly Tyr Gly Tyr Phe Gln Ala Gly 
        195                 200                 205             


Asn Asn Leu Met Met Ile Glu Gln Tyr Pro Tyr Val Val Ile Met 
    210                 215                 220             


<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161
<211>  129
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  161

Asp Gln Val Asp Val Lys Asp Cys Ala Asn His Glu Ile Lys Lys Val 
1               5                   10                  15      


Leu Val Pro Gly Cys His Gly Ser Glu Pro Cys Ile Ile His Arg Gly 
            20                  25                  30          


Lys Pro Phe Gln Leu Glu Ala Val Phe Glu Ala Asn Gln Asn Thr Lys 
        35                  40                  45              


Thr Ala Lys Ile Glu Ile Lys Ala Ser Ile Asp Gly Leu Glu Val Asp 
    50                  55                  60                  


Val Pro Gly Ile Asp Pro Asn Ala Cys His Tyr Met Lys Cys Pro Leu 
65                  70                  75                  80  


Val Lys Gly Gln Gln Tyr Asp Ile Lys Tyr Thr Trp Asn Val Pro Lys 
                85                  90                  95      


Ile Ala Pro Lys Ser Glu Asn Val Val Val Thr Val Lys Val Met Gly 
            100                 105                 110         


Asp Asp Gly Val Leu Ala Cys Ala Ile Ala Thr His Ala Lys Ile Arg 
        115                 120                 125             


Asp 
    


<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165
<211>  129
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  165

Asp Gln Val Asp Val Lys Asp Cys Ala Asn Asn Glu Ile Lys Lys Val 
1               5                   10                  15      


Met Val Asp Gly Cys His Gly Ser Asp Pro Cys Ile Ile His Arg Gly 
            20                  25                  30          


Lys Pro Phe Thr Leu Glu Ala Leu Phe Asp Ala Asn Gln Asn Thr Lys 
        35                  40                  45              


Thr Ala Lys Ile Glu Val Lys Ala Ser Leu Asp Gly Leu Glu Ile Asp 
    50                  55                  60                  


Val Pro Gly Ile Asp Thr Asn Ala Cys His Phe Val Lys Cys Pro Leu 
65                  70                  75                  80  


Val Lys Gly Gln Gln Tyr Asp Ile Lys Tyr Thr Trp Asn Val Pro Lys 
                85                  90                  95      


Ile Ala Pro Lys Ser Glu Asn Val Val Val Thr Val Lys Leu Ile Gly 
            100                 105                 110         


Asp Asn Gly Val Leu Ala Cys Ala Ile Ala Thr His Gly Lys Ile Arg 
        115                 120                 125             


Asp 
    


<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169
<211>  212
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  169

Thr Asn Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile Asp Leu 
1               5                   10                  15      


Arg Gln Met Arg Thr Val Thr Pro Ile Arg Ser Gly Val Ala Ala Thr 
            20                  25                  30          


Glu Ser Ala Tyr Leu Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu 
        35                  40                  45              


Gln Glu Leu Val Asp Cys Ala Ser Gln His Asn Gly Cys His Gly Asp 
    50                  55                  60                  


Thr Ile Pro Arg Gly Ile Glu Tyr Ile Gln His Asn Gly Val Val Gln 
65                  70                  75                  80  


Glu Ser Tyr Tyr Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg Arg Pro 
                85                  90                  95      


Asn Ala Gln Arg Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Gln 
            100                 105                 110         


Asn Val Asn Lys Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala Ile 
        115                 120                 125             


Ala Val Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr Asp 
    130                 135                 140                 


Gly Arg Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr His 
145                 150                 155                 160 


Ala Val Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly Val Asp Tyr Trp 
                165                 170                 175     


Ile Val Arg Asn Ser Trp Asp Thr Asn Trp Gly Asp Asn Gly Tyr Gly 
            180                 185                 190         


Tyr Phe Ala Ala Asn Ile Asp Leu Met Met Ile Glu Glu Tyr Pro Tyr 
        195                 200                 205             


Val Val Ile Leu 
    210         


<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173
<211>  177
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  173

Glu Ile Cys Pro Ala Val Lys Arg Asp Val Asp Leu Phe Leu Thr Gly 
1               5                   10                  15      


Thr Pro Asp Glu Tyr Val Glu Gln Val Ala Gln Tyr Lys Ala Leu Pro 
            20                  25                  30          


Val Val Leu Glu Asn Ala Arg Ile Leu Lys Asn Cys Val Asp Ala Lys 
        35                  40                  45              


Met Thr Glu Glu Asp Lys Glu Asn Ala Leu Ser Leu Leu Asp Lys Ile 
    50                  55                  60                  


Tyr Thr Ser Pro Leu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Val Lys Met Ala Glu Thr Cys Pro Ile Phe Tyr 
                85                  90                  95      


Asp Val Phe Phe Ala Val Ala Asn Gly Asn Glu Leu Leu Leu Asp Leu 
            100                 105                 110         


Ser Leu Thr Lys Val Asn Ala Thr Glu Pro Glu Arg Thr Ala Met Lys 
        115                 120                 125             


Lys Ile Gln Asp Cys Tyr Val Glu Asn Gly Leu Ile Ser Arg Val Leu 
    130                 135                 140                 


Asp Gly Leu Val Met Thr Thr Ile Ser Ser Ser Lys Asp Cys Met Gly 
145                 150                 155                 160 


Glu Ala Val Gln Asn Thr Val Glu Asp Leu Lys Leu Asn Thr Leu Gly 
                165                 170                 175     


Arg 
    


<210>  174
<211>  162
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  174

Glu Ile Cys Pro Ala Val Lys Arg Asp Val Asp Leu Phe Leu Thr Gly 
1               5                   10                  15      


Thr Pro Asp Glu Tyr Val Glu Gln Val Ala Gln Tyr Lys Ala Leu Pro 
            20                  25                  30          


Val Val Leu Glu Asn Ala Arg Ile Leu Lys Asn Cys Val Asp Ala Lys 
        35                  40                  45              


Met Thr Glu Glu Asp Lys Glu Asn Ala Leu Ser Leu Leu Asp Lys Ile 
    50                  55                  60                  


Tyr Thr Ser Pro Leu Cys Val Lys Met Ala Glu Thr Cys Pro Ile Phe 
65                  70                  75                  80  


Tyr Asp Val Phe Phe Ala Val Ala Asn Gly Asn Glu Leu Leu Leu Asp 
                85                  90                  95      


Leu Ser Leu Thr Lys Val Asn Ala Thr Glu Pro Glu Arg Thr Ala Met 
            100                 105                 110         


Lys Lys Ile Gln Asp Cys Tyr Val Glu Asn Gly Leu Ile Ser Arg Val 
        115                 120                 125             


Leu Asp Gly Leu Val Met Thr Thr Ile Ser Ser Ser Lys Asp Cys Met 
    130                 135                 140                 


Gly Glu Ala Val Gln Asn Thr Val Glu Asp Leu Lys Leu Asn Thr Leu 
145                 150                 155                 160 


Gly Arg 
        


<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178
<211>  584
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  178

Glu Ala His Gln Ser Glu Ile Ala His Arg Phe Asn Asp Leu Gly Glu 
1               5                   10                  15      


Glu His Phe Arg Gly Leu Val Leu Val Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Gly Cys Val Ala Asp Gln Ser Ala Ala Asn Cys Glu Lys 
    50                  55                  60                  


Ser Leu His Glu Leu Leu Gly Asp Lys Leu Cys Thr Val Ala Ser Leu 
65                  70                  75                  80  


Arg Asp Lys Tyr Gly Glu Met Ala Asp Cys Cys Glu Lys Lys Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Gly Phe 
            100                 105                 110         


Gly Gln Leu Val Thr Pro Glu Ala Asp Ala Met Cys Thr Ala Phe His 
        115                 120                 125             


Glu Asn Glu Gln Arg Phe Leu Gly Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Glu 
145                 150                 155                 160 


Tyr Lys Gly Val Phe Thr Glu Cys Cys Glu Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Thr Pro Lys Val Asp Ala Leu Arg Glu Lys Val Leu Ala Ser 
            180                 185                 190         


Ser Ala Lys Glu Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ser Val Ala Arg Leu Ser Gln Lys Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Ile Ser Lys Leu Val Thr Asp Leu Ala Lys 
225                 230                 235                 240 


Ile His Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Thr Lys Leu Lys Glu Cys Cys Gly Lys Pro Val Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ser Glu Val Glu Arg Asp Glu Leu Pro Ala Asp Leu Pro Pro 
    290                 295                 300                 


Leu Ala Val Asp Phe Val Glu Asp Lys Glu Val Cys Lys Asn Tyr Gln 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Glu Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Glu 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Thr Asp Asp Pro Pro Ala 
        355                 360                 365             


Cys Tyr Ala His Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


His Asn Leu Val Lys Thr Asn Cys Glu Leu Phe Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Ser Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Thr His Pro Glu Ala Glu Arg Leu Ser Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Arg Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Gln Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Ser Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Leu Cys Thr Leu Pro Glu Ala Glu Lys Gln Ile Lys Lys Gln Ser Ala 
        515                 520                 525             


Leu Val Glu Leu Leu Lys His Lys Pro Lys Ala Thr Glu Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Gly Asp Phe Gly Ser Phe Val Asp Lys Cys Cys Ala 
545                 550                 555                 560 


Ala Glu Asp Lys Glu Ala Cys Phe Ala Glu Glu Gly Pro Lys Leu Val 
                565                 570                 575     


Ala Ala Ala Gln Ala Ala Leu Ala 
            580                 


<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182
<211>  171
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  182

His Glu Glu Glu Asn Val Val Arg Ser Asn Ile Asp Ile Ser Lys Ile 
1               5                   10                  15      


Ser Gly Glu Trp Tyr Ser Ile Leu Leu Ala Ser Asp Val Lys Glu Lys 
            20                  25                  30          


Ile Glu Glu Asn Gly Ser Met Arg Val Phe Val Glu His Ile Lys Ala 
        35                  40                  45              


Leu Asp Asn Ser Ser Leu Ser Phe Val Phe His Thr Lys Glu Asn Gly 
    50                  55                  60                  


Lys Cys Thr Glu Ile Phe Leu Val Ala Asp Lys Thr Lys Asp Gly Val 
65                  70                  75                  80  


Tyr Thr Val Val Tyr Asp Gly Tyr Asn Val Phe Ser Ile Val Glu Thr 
                85                  90                  95      


Val Tyr Asp Glu Tyr Ile Leu Leu His Leu Leu Asn Phe Asp Lys Thr 
            100                 105                 110         


Arg Pro Phe Gln Leu Val Glu Phe Tyr Ala Arg Glu Pro Asp Val Ser 
        115                 120                 125             


Gln Lys Leu Lys Glu Lys Phe Val Lys Tyr Cys Gln Glu His Gly Ile 
    130                 135                 140                 


Val Asn Ile Leu Asp Leu Thr Glu Val Asp Arg Cys Leu Gln Ala Arg 
145                 150                 155                 160 


Gly Ser Glu Val Ala Gln Asp Ser Ser Val Glu 
                165                 170     


<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186
<211>  284
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  186

Met Asp Ala Ile Lys Lys Lys Met Gln Ala Met Lys Leu Glu Lys Asp 
1               5                   10                  15      


Asn Ala Met Asp Arg Ala Asp Thr Leu Glu Gln Gln Asn Lys Glu Ala 
            20                  25                  30          


Asn Asn Arg Ala Glu Lys Ser Glu Glu Glu Val His Asn Leu Gln Lys 
        35                  40                  45              


Arg Met Gln Gln Leu Glu Asn Asp Leu Asp Gln Val Gln Glu Ser Leu 
    50                  55                  60                  


Leu Lys Ala Asn Ile Gln Leu Val Glu Lys Asp Lys Ala Leu Ser Asn 
65                  70                  75                  80  


Ala Glu Gly Glu Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Leu Glu 
                85                  90                  95      


Glu Asp Leu Glu Arg Ser Glu Glu Arg Leu Asn Thr Ala Thr Thr Lys 
            100                 105                 110         


Leu Ala Glu Ala Ser Gln Ala Ala Asp Glu Ser Glu Arg Met Arg Lys 
        115                 120                 125             


Val Leu Glu Asn Arg Ser Leu Ser Asp Glu Glu Arg Met Asp Ala Leu 
    130                 135                 140                 


Glu Asn Gln Leu Lys Glu Ala Arg Phe Leu Ala Glu Glu Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Asp Glu Val Ala Arg Lys Leu Ala Met Val Glu Ala Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Thr Gly Glu Ser Lys Ile Val Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Arg Val Val Gly Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Val Ser Glu Glu Lys Ala Asn Gln Arg Glu Glu Ala Tyr Lys Glu Gln 
    210                 215                 220                 


Ile Lys Thr Leu Thr Asn Lys Leu Lys Ala Ala Glu Ala Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Gln Lys Leu Gln Lys Glu Val Asp Arg Leu 
                245                 250                 255     


Glu Asp Glu Leu Val Asn Glu Lys Glu Lys Tyr Lys Ser Ile Thr Asp 
            260                 265                 270         


Glu Leu Asp Gln Thr Phe Ser Glu Leu Ser Gly Tyr 
        275                 280                 


<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190
<211>  247
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  190

Ala Asp Ala Gly Tyr Thr Pro Ala Ala Ala Ala Thr Pro Ala Thr Pro 
1               5                   10                  15      


Ala Ala Thr Pro Ala Ala Ala Gly Gly Lys Ala Thr Thr Asp Glu Gln 
            20                  25                  30          


Lys Leu Leu Glu Asp Val Asn Ala Gly Phe Lys Ala Ala Val Ala Ala 
        35                  40                  45              


Ala Ala Asn Ala Pro Pro Ala Asp Lys Phe Lys Ile Phe Glu Ala Ala 
    50                  55                  60                  


Phe Ser Glu Ser Ser Lys Gly Leu Leu Ala Thr Ser Ala Ala Lys Ala 
65                  70                  75                  80  


Pro Gly Leu Ile Pro Lys Leu Asp Thr Ala Tyr Asp Val Ala Tyr Lys 
                85                  90                  95      


Ala Ala Glu Ala Thr Pro Glu Ala Lys Tyr Asp Ala Phe Val Thr Ala 
            100                 105                 110         


Leu Thr Glu Ala Leu Arg Val Ile Ala Gly Ala Leu Glu Val His Ala 
        115                 120                 125             


Val Lys Pro Ala Thr Glu Glu Val Leu Ala Ala Lys Ile Pro Thr Gly 
    130                 135                 140                 


Glu Leu Gln Ile Val Asp Lys Ile Asp Ala Ala Phe Lys Ile Ala Ala 
145                 150                 155                 160 


Thr Ala Ala Asn Ala Ala Pro Thr Asn Asp Lys Phe Thr Val Phe Glu 
                165                 170                 175     


Ser Ala Phe Asn Lys Ala Leu Asn Glu Cys Thr Gly Gly Ala Tyr Glu 
            180                 185                 190         


Thr Tyr Lys Phe Ile Pro Ser Leu Glu Ala Ala Val Lys Gln Ala Tyr 
        195                 200                 205             


Ala Ala Thr Val Ala Ala Ala Pro Glu Val Lys Tyr Ala Val Phe Glu 
    210                 215                 220                 


Ala Ala Leu Thr Lys Ala Ile Thr Ala Met Thr Gln Ala Gln Lys Ala 
225                 230                 235                 240 


Gly Lys Pro Ala Ala Ala Ala 
                245         


<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194
<211>  240
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  194

Ile Pro Lys Val Pro Pro Gly Pro Asn Ile Thr Ala Thr Tyr Gly Asp 
1               5                   10                  15      


Lys Trp Leu Asp Ala Lys Ser Thr Trp Tyr Gly Lys Pro Thr Gly Ala 
            20                  25                  30          


Gly Pro Lys Asp Asn Gly Gly Ala Cys Gly Tyr Lys Asp Val Asp Lys 
        35                  40                  45              


Pro Pro Phe Ser Gly Met Thr Gly Cys Gly Asn Thr Pro Ile Phe Lys 
    50                  55                  60                  


Ser Gly Arg Gly Cys Gly Ser Cys Phe Glu Ile Lys Cys Thr Lys Pro 
65                  70                  75                  80  


Glu Ala Cys Ser Gly Glu Pro Val Val Val His Ile Thr Asp Asp Asn 
                85                  90                  95      


Glu Glu Pro Ile Ala Pro Tyr His Phe Asp Leu Ser Gly His Ala Phe 
            100                 105                 110         


Gly Ala Met Ala Lys Lys Gly Asp Glu Gln Lys Leu Arg Ser Ala Gly 
        115                 120                 125             


Glu Leu Glu Leu Gln Phe Arg Arg Val Lys Cys Lys Tyr Pro Glu Gly 
    130                 135                 140                 


Thr Lys Val Thr Phe His Val Glu Lys Gly Ser Asn Pro Asn Tyr Leu 
145                 150                 155                 160 


Ala Leu Leu Val Lys Tyr Val Asn Gly Asp Gly Asp Val Val Ala Val 
                165                 170                 175     


Asp Ile Lys Glu Lys Gly Lys Asp Lys Trp Ile Glu Leu Lys Glu Ser 
            180                 185                 190         


Trp Gly Ala Ile Trp Arg Ile Asp Thr Pro Asp Lys Leu Thr Gly Pro 
        195                 200                 205             


Phe Thr Val Arg Tyr Thr Thr Glu Gly Gly Thr Lys Thr Glu Ala Glu 
    210                 215                 220                 


Asp Val Ile Pro Glu Gly Trp Lys Ala Asp Thr Ser Tyr Glu Ser Lys 
225                 230                 235                 240 


<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198
<211>  264
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  198

Ala Ala Asp Leu Gly Tyr Gly Pro Ala Thr Pro Ala Ala Pro Ala Ala 
1               5                   10                  15      


Gly Tyr Thr Pro Ala Thr Pro Ala Ala Pro Ala Glu Ala Ala Pro Ala 
            20                  25                  30          


Gly Lys Ala Thr Thr Glu Glu Gln Lys Leu Ile Glu Lys Ile Asn Ala 
        35                  40                  45              


Gly Phe Lys Ala Ala Leu Ala Ala Ala Ala Gly Val Gln Pro Ala Asp 
    50                  55                  60                  


Lys Tyr Arg Thr Phe Val Ala Thr Phe Gly Ala Ala Ser Asn Lys Ala 
65                  70                  75                  80  


Phe Ala Glu Gly Leu Ser Gly Glu Pro Lys Gly Ala Ala Glu Ser Ser 
                85                  90                  95      


Ser Lys Ala Ala Leu Thr Ser Lys Leu Asp Ala Ala Tyr Lys Leu Ala 
            100                 105                 110         


Tyr Lys Thr Ala Glu Gly Ala Thr Pro Glu Ala Lys Tyr Asp Ala Tyr 
        115                 120                 125             


Val Ala Thr Leu Ser Glu Ala Leu Arg Ile Ile Ala Gly Thr Leu Glu 
    130                 135                 140                 


Val His Ala Val Lys Pro Ala Ala Glu Glu Val Lys Val Ile Pro Ala 
145                 150                 155                 160 


Gly Glu Leu Gln Val Ile Glu Lys Val Asp Ala Ala Phe Lys Val Ala 
                165                 170                 175     


Ala Thr Ala Ala Asn Ala Ala Pro Ala Asn Asp Lys Phe Thr Val Phe 
            180                 185                 190         


Glu Ala Ala Phe Asn Asp Ala Ile Lys Ala Ser Thr Gly Gly Ala Tyr 
        195                 200                 205             


Glu Ser Tyr Lys Phe Ile Pro Ala Leu Glu Ala Ala Val Lys Gln Ala 
    210                 215                 220                 


Tyr Ala Ala Thr Val Ala Thr Ala Pro Glu Val Lys Tyr Thr Val Phe 
225                 230                 235                 240 


Glu Thr Ala Leu Lys Lys Ala Ile Thr Ala Met Ser Glu Ala Gln Lys 
                245                 250                 255     


Ala Ala Lys Pro Ala Ala Ala Ala 
            260                 


<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201
<211>  536
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  201

Ser Ile Lys Arg Asp His Asn Asp Tyr Ser Lys Asn Pro Met Arg Ile 
1               5                   10                  15      


Val Cys Tyr Val Gly Thr Trp Ser Val Tyr His Lys Val Asp Pro Tyr 
            20                  25                  30          


Thr Ile Glu Asp Ile Asp Pro Phe Lys Cys Thr His Leu Met Tyr Gly 
        35                  40                  45              


Phe Ala Lys Ile Asp Glu Tyr Lys Tyr Thr Ile Gln Val Phe Asp Pro 
    50                  55                  60                  


Tyr Gln Asp Asp Asn His Asn Ser Trp Glu Lys Arg Gly Tyr Glu Arg 
65                  70                  75                  80  


Phe Asn Asn Leu Arg Leu Lys Asn Pro Glu Leu Thr Thr Met Ile Ser 
                85                  90                  95      


Leu Gly Gly Trp Tyr Glu Gly Ser Glu Lys Tyr Ser Asp Met Ala Ala 
            100                 105                 110         


Asn Pro Thr Tyr Arg Gln Gln Phe Ile Gln Ser Val Leu Asp Phe Leu 
        115                 120                 125             


Gln Glu Tyr Lys Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly 
    130                 135                 140                 


Ser Arg Leu Gly Asn Pro Lys Ile Asp Lys Gln Asn Tyr Leu Ala Leu 
145                 150                 155                 160 


Val Arg Glu Leu Lys Asp Ala Phe Glu Pro His Gly Tyr Leu Leu Thr 
                165                 170                 175     


Ala Ala Val Ser Pro Gly Lys Asp Lys Ile Asp Arg Ala Tyr Asp Ile 
            180                 185                 190         


Lys Glu Leu Asn Lys Leu Phe Asp Trp Met Asn Val Met Thr Tyr Asp 
        195                 200                 205             


Tyr His Gly Gly Trp Glu Asn Phe Tyr Gly His Asn Ala Pro Leu Tyr 
    210                 215                 220                 


Lys Arg Pro Asp Glu Thr Asp Glu Leu His Thr Tyr Phe Asn Val Asn 
225                 230                 235                 240 


Tyr Thr Met His Tyr Tyr Leu Asn Asn Gly Ala Thr Arg Asp Lys Leu 
                245                 250                 255     


Val Met Gly Val Pro Phe Tyr Gly Arg Ala Trp Ser Ile Glu Asp Arg 
            260                 265                 270         


Ser Lys Leu Lys Leu Gly Asp Pro Ala Lys Gly Met Ser Pro Pro Gly 
        275                 280                 285             


Phe Ile Ser Gly Glu Glu Gly Val Leu Ser Tyr Ile Glu Leu Cys Gln 
    290                 295                 300                 


Leu Phe Gln Lys Glu Glu Trp His Ile Gln Tyr Asp Glu Tyr Tyr Asn 
305                 310                 315                 320 


Ala Pro Tyr Gly Tyr Asn Asp Lys Ile Trp Val Gly Tyr Asp Asp Leu 
                325                 330                 335     


Ala Ser Ile Ser Cys Lys Leu Ala Phe Leu Lys Glu Leu Gly Val Ser 
            340                 345                 350         


Gly Val Met Val Trp Ser Leu Glu Asn Asp Asp Phe Lys Gly His Cys 
        355                 360                 365             


Gly Pro Lys Asn Pro Leu Leu Asn Lys Val His Asn Met Ile Asn Gly 
    370                 375                 380                 


Asp Glu Lys Asn Ser Phe Glu Cys Ile Leu Gly Pro Ser Thr Thr Thr 
385                 390                 395                 400 


Pro Thr Pro Thr Thr Thr Pro Thr Thr Pro Thr Thr Thr Pro Thr Thr 
                405                 410                 415     


Pro Ser Pro Thr Thr Pro Thr Thr Thr Pro Ser Pro Thr Thr Pro Thr 
            420                 425                 430         


Thr Thr Pro Ser Pro Thr Thr Pro Thr Thr Thr Pro Ser Pro Thr Thr 
        435                 440                 445             


Pro Thr Pro Thr Thr Pro Thr Pro Ala Pro Thr Thr Ser Thr Pro Ser 
    450                 455                 460                 


Pro Thr Thr Thr Glu His Thr Ser Glu Thr Pro Lys Tyr Thr Thr Tyr 
465                 470                 475                 480 


Val Asp Gly His Leu Ile Lys Cys Tyr Lys Glu Gly Asp Ile Pro His 
                485                 490                 495     


Pro Thr Asn Ile His Lys Tyr Leu Val Cys Glu Phe Val Asn Gly Gly 
            500                 505                 510         


Trp Trp Val His Ile Met Pro Cys Pro Pro Gly Thr Ile Trp Cys Gln 
        515                 520                 525             


Glu Lys Leu Thr Cys Ile Gly Glu 
    530                 535     


<210>  202
<211>  424
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  202

Ser Asn Ile Arg Pro Asn Val Ala Thr Leu Glu Pro Lys Thr Val Cys 
1               5                   10                  15      


Tyr Tyr Glu Ser Trp Val His Trp Arg Gln Gly Glu Gly Lys Met Asp 
            20                  25                  30          


Pro Glu Asp Ile Asp Thr Ser Leu Cys Thr His Ile Val Tyr Ser Tyr 
        35                  40                  45              


Phe Gly Ile Asp Ala Ala Thr His Glu Ile Lys Leu Leu Asp Glu Tyr 
    50                  55                  60                  


Leu Met Lys Asp Leu His Asp Met Glu His Phe Thr Gln His Lys Gly 
65                  70                  75                  80  


Asn Ala Lys Ala Met Ile Ala Val Gly Gly Ser Thr Met Ser Asp Gln 
                85                  90                  95      


Phe Ser Lys Thr Ala Ala Val Glu His Tyr Arg Glu Thr Phe Val Val 
            100                 105                 110         


Ser Thr Val Asp Leu Met Thr Arg Tyr Gly Phe Asp Gly Val Met Ile 
        115                 120                 125             


Asp Trp Ser Gly Met Gln Ala Lys Asp Ser Asp Asn Phe Ile Lys Leu 
    130                 135                 140                 


Leu Asp Lys Phe Asp Glu Asn Tyr Asn Ile Pro Ala Ile Ser Asn Tyr 
145                 150                 155                 160 


Val Asp Phe Met Asn Val Leu Ser Leu Asp Tyr Thr Gly Ser Trp Ala 
                165                 170                 175     


His Thr Val Gly His Ala Ser Pro Phe Pro Glu Gln Leu Lys Thr Leu 
            180                 185                 190         


Glu Ala Tyr His Lys Arg Gly Ala Pro Arg His Lys Met Val Met Ala 
        195                 200                 205             


Val Pro Phe Tyr Ala Arg Thr Trp Ile Leu Glu Lys Met Asn Lys Gln 
    210                 215                 220                 


Asp Ile Gly Asp Lys Ala Ser Gly Pro Gly Pro Arg Gly Gln Phe Thr 
225                 230                 235                 240 


Gln Thr Asp Gly Phe Leu Ser Tyr Asn Glu Leu Cys Val Gln Ile Gln 
                245                 250                 255     


Ala Glu Thr Asn Ala Phe Thr Ile Thr Arg Asp His Asp Asn Thr Ala 
            260                 265                 270         


Ile Tyr Ala Val Tyr Val His Ser Asn His Ala Glu Trp Ile Ser Phe 
        275                 280                 285             


Glu Asp Arg His Thr Leu Gly Glu Lys Ala Lys Asn Ile Thr Gln Gln 
    290                 295                 300                 


Gly Tyr Ala Gly Met Ser Val Tyr Thr Leu Ser Asn Glu Asp Val His 
305                 310                 315                 320 


Gly Val Cys Gly Asp Lys Asn Pro Leu Leu His Ala Ile Gln Ser Asn 
                325                 330                 335     


Tyr Tyr His Gly Val Val Thr Glu Pro Thr Val Val Thr Leu Pro Pro 
            340                 345                 350         


Val Thr His Thr Thr Glu His Val Thr Asp Ile Pro Gly Val Phe His 
        355                 360                 365             


Cys His Glu Glu Gly Phe Phe Arg Asp Lys Thr Tyr Cys Ala Thr Tyr 
    370                 375                 380                 


Tyr Glu Cys Lys Lys Gly Asp Phe Gly Leu Glu Lys Thr Val His His 
385                 390                 395                 400 


Cys Ala Asn His Leu Gln Ala Phe Asp Glu Val Ser Arg Thr Cys Ile 
                405                 410                 415     


Asp His Thr Lys Ile Pro Gly Cys 
            420                 


<210>  203
<211>  478
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  203

Asn Pro Arg Phe Lys Arg Asp Asn Arg Asp Asp Val Leu Lys Gln Thr 
1               5                   10                  15      


Glu Glu Leu Ile Lys Ser Ala Gln Asp Val Leu Glu Lys Leu Pro Asp 
            20                  25                  30          


Ser Asp Leu Lys Asp Glu Ile Ala Glu Lys Leu Ala Thr Met Lys His 
        35                  40                  45              


Tyr Lys His Glu Leu Glu Asn Ala Lys Asn Pro Ile Lys Ile Ala His 
    50                  55                  60                  


Phe Glu Leu Glu Leu Leu Thr Met Phe Lys Lys Phe Gln Ser Leu Leu 
65                  70                  75                  80  


Asn Glu Ala Asn Glu Ile Ile Lys Ser Leu Thr Thr Thr Thr Thr Glu 
                85                  90                  95      


Pro Thr Thr Pro Thr Pro Glu Pro Thr Thr Thr Thr Pro Glu Pro Thr 
            100                 105                 110         


Thr Lys Thr Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro Thr Thr Pro 
        115                 120                 125             


Thr Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro Thr Thr Lys Thr Pro 
    130                 135                 140                 


Glu Pro Thr Thr Pro Thr Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro 
145                 150                 155                 160 


Thr Thr Pro Thr Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro Thr Thr 
                165                 170                 175     


Lys Thr Pro Glu Pro Ser Thr Pro Thr Pro Glu Pro Thr Thr Lys Thr 
            180                 185                 190         


Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro Ser Thr Pro Thr Pro Glu 
        195                 200                 205             


Pro Thr Thr Lys Thr Pro Glu Pro Ser Thr Pro Thr Pro Glu Pro Thr 
    210                 215                 220                 


Thr Lys Thr Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro Ser Thr Pro 
225                 230                 235                 240 


Thr Pro Glu Pro Thr Thr Lys Thr Pro Glu Pro Ser Thr Pro Thr Pro 
                245                 250                 255     


Glu Pro Thr Thr Lys Thr Pro Glu Pro Ser Thr Thr Lys Lys Pro Asn 
            260                 265                 270         


Arg Asp Asp Val Leu Lys Gln Ala Glu Glu Leu Ile Lys Arg Ala Glu 
        275                 280                 285             


Asp Val Phe Glu Lys Leu Pro Asp Ser Asp Leu Lys Asn Glu Ile Ala 
    290                 295                 300                 


Glu Lys Leu Ala Thr Met Lys Asn Tyr Lys His Glu Leu Glu Asn Ala 
305                 310                 315                 320 


Lys Asn Pro Ile Lys Ile Ala His Leu Glu Ser Glu Leu Leu Thr Met 
                325                 330                 335     


Phe Lys Met Phe Gln Ser Leu Leu Asn Glu Ala Asp Glu Ile Ile Arg 
            340                 345                 350         


Ser Leu Thr Thr Thr Thr Glu Pro Thr Thr Leu Asn Ser Thr Thr Pro 
        355                 360                 365             


Glu Pro Thr Thr Leu Asn Ser Thr Thr Pro Glu Pro Thr Thr Leu Asn 
    370                 375                 380                 


Ser Thr Thr Pro Glu Pro Thr Thr Leu Asn Ser Thr Thr Pro Glu Pro 
385                 390                 395                 400 


Thr Thr Leu Asn Ser Thr Thr Pro Glu Pro Thr Thr Leu Asn Ser Thr 
                405                 410                 415     


Thr Pro Glu Pro Thr Thr Leu Asn Ser Thr Thr Pro Glu Pro Thr Thr 
            420                 425                 430         


Leu Asn Ser Thr Thr Pro Glu Pro Thr Thr Ser Asn Ser Thr Thr Ser 
        435                 440                 445             


Glu Pro Thr Asn Ser Ile Asn Arg Lys Thr Ser Glu Ile Ser Phe Leu 
    450                 455                 460                 


Ser Asp Trp Phe His Lys Ile Arg Thr Arg Phe Asn Ile Phe 
465                 470                 475             


<210>  204
<211>  158
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  204

Glu Asp Ile Trp Lys Val Asn Lys Lys Cys Thr Ser Gly Gly Lys Asn 
1               5                   10                  15      


Gln Asp Arg Lys Leu Asp Gln Ile Ile Gln Lys Gly Gln Gln Val Lys 
            20                  25                  30          


Ile Gln Asn Ile Cys Lys Leu Ile Arg Asp Lys Pro His Thr Asn Gln 
        35                  40                  45              


Glu Lys Glu Lys Cys Met Lys Phe Cys Lys Lys Val Cys Lys Gly Tyr 
    50                  55                  60                  


Arg Gly Ala Cys Asp Gly Asn Ile Cys Tyr Cys Ser Arg Pro Ser Asn 
65                  70                  75                  80  


Leu Gly Pro Asp Trp Lys Val Ser Lys Glu Cys Lys Asp Pro Asn Asn 
                85                  90                  95      


Lys Asp Ser Arg Pro Thr Glu Ile Val Pro Tyr Arg Gln Gln Leu Ala 
            100                 105                 110         


Ile Pro Asn Ile Cys Lys Leu Lys Asn Ser Glu Thr Asn Glu Asp Ser 
        115                 120                 125             


Lys Cys Lys Lys His Cys Lys Glu Lys Cys Arg Gly Gly Asn Asp Ala 
    130                 135                 140                 


Gly Cys Asp Gly Asn Phe Cys Tyr Cys Arg Pro Lys Asn Lys 
145                 150                 155             


<210>  205
<211>  965
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  205

Ser Ile Lys Arg Asp His Asn Asp Tyr Ser Lys Asn Pro Met Arg Ile 
1               5                   10                  15      


Val Cys Tyr Val Gly Thr Trp Ser Val Tyr His Lys Val Asp Pro Tyr 
            20                  25                  30          


Thr Ile Glu Asp Ile Asp Pro Phe Lys Cys Thr His Leu Met Tyr Gly 
        35                  40                  45              


Phe Ala Lys Ile Asp Glu Tyr Lys Tyr Thr Ile Gln Val Phe Asp Pro 
    50                  55                  60                  


Tyr Gln Asp Asp Asn His Asn Ser Trp Glu Lys Arg Gly Tyr Glu Arg 
65                  70                  75                  80  


Phe Asn Asn Leu Arg Leu Lys Asn Pro Glu Leu Thr Thr Met Ile Ser 
                85                  90                  95      


Leu Gly Gly Trp Tyr Glu Gly Ser Glu Lys Tyr Ser Asp Met Ala Ala 
            100                 105                 110         


Asn Pro Thr Tyr Arg Gln Gln Phe Ile Gln Ser Val Leu Asp Phe Leu 
        115                 120                 125             


Gln Glu Tyr Lys Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly 
    130                 135                 140                 


Ser Arg Leu Gly Asn Pro Lys Ile Asp Lys Gln Asn Tyr Leu Ala Leu 
145                 150                 155                 160 


Val Arg Glu Leu Lys Asp Ala Phe Glu Pro His Gly Tyr Leu Leu Thr 
                165                 170                 175     


Ala Ala Val Ser Pro Gly Lys Asp Lys Ile Asp Arg Ala Tyr Asp Ile 
            180                 185                 190         


Lys Glu Leu Asn Lys Leu Phe Asp Trp Met Asn Val Met Thr Tyr Asp 
        195                 200                 205             


Tyr His Gly Gly Trp Glu Asn Phe Tyr Gly His Asn Ala Pro Leu Tyr 
    210                 215                 220                 


Lys Arg Pro Asp Glu Thr Asp Glu Leu His Thr Tyr Phe Asn Val Asn 
225                 230                 235                 240 


Tyr Thr Met His Tyr Tyr Leu Asn Asn Gly Ala Thr Arg Asp Lys Leu 
                245                 250                 255     


Val Met Gly Val Pro Phe Tyr Gly Arg Ala Trp Ser Ile Glu Asp Arg 
            260                 265                 270         


Ser Lys Leu Lys Leu Gly Asp Pro Ala Lys Gly Met Ser Pro Pro Gly 
        275                 280                 285             


Phe Ile Ser Gly Glu Glu Gly Val Leu Ser Tyr Ile Glu Leu Cys Gln 
    290                 295                 300                 


Leu Phe Gln Lys Glu Glu Trp His Ile Gln Tyr Asp Glu Tyr Tyr Asn 
305                 310                 315                 320 


Ala Pro Tyr Gly Tyr Asn Asp Lys Ile Trp Val Gly Tyr Asp Asp Leu 
                325                 330                 335     


Ala Ser Ile Ser Cys Lys Leu Ala Phe Leu Lys Glu Leu Gly Val Ser 
            340                 345                 350         


Gly Val Met Val Trp Ser Leu Glu Asn Asp Asp Phe Lys Gly His Cys 
        355                 360                 365             


Gly Pro Lys Asn Pro Leu Leu Asn Lys Val His Asn Met Ile Asn Gly 
    370                 375                 380                 


Asp Glu Lys Asn Ser Phe Glu Cys Ile Leu Gly Pro Ser Thr Thr Thr 
385                 390                 395                 400 


Pro Thr Pro Thr Thr Thr Pro Thr Thr Pro Thr Thr Thr Pro Thr Thr 
                405                 410                 415     


Pro Ser Pro Thr Thr Pro Thr Thr Thr Pro Ser Pro Thr Thr Pro Thr 
            420                 425                 430         


Thr Thr Pro Ser Pro Thr Thr Pro Thr Thr Thr Pro Ser Pro Thr Thr 
        435                 440                 445             


Pro Thr Pro Thr Thr Pro Thr Pro Ala Pro Thr Thr Ser Thr Pro Ser 
    450                 455                 460                 


Pro Thr Thr Thr Glu His Thr Ser Glu Thr Pro Lys Tyr Thr Thr Tyr 
465                 470                 475                 480 


Val Asp Gly His Leu Ile Lys Cys Tyr Lys Glu Gly Asp Ile Pro His 
                485                 490                 495     


Pro Thr Asn Ile His Lys Tyr Leu Val Cys Glu Phe Val Asn Gly Gly 
            500                 505                 510         


Trp Trp Val His Ile Met Pro Cys Pro Pro Gly Thr Ile Trp Cys Gln 
        515                 520                 525             


Glu Lys Leu Thr Cys Ile Gly Glu Gly Pro Gly Pro Gly Ser Asn Ile 
    530                 535                 540                 


Arg Pro Asn Val Ala Thr Leu Glu Pro Lys Thr Val Cys Tyr Tyr Glu 
545                 550                 555                 560 


Ser Trp Val His Trp Arg Gln Gly Glu Gly Lys Met Asp Pro Glu Asp 
                565                 570                 575     


Ile Asp Thr Ser Leu Cys Thr His Ile Val Tyr Ser Tyr Phe Gly Ile 
            580                 585                 590         


Asp Ala Ala Thr His Glu Ile Lys Leu Leu Asp Glu Tyr Leu Met Lys 
        595                 600                 605             


Asp Leu His Asp Met Glu His Phe Thr Gln His Lys Gly Asn Ala Lys 
    610                 615                 620                 


Ala Met Ile Ala Val Gly Gly Ser Thr Met Ser Asp Gln Phe Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Val Glu His Tyr Arg Glu Thr Phe Val Val Ser Thr Val 
                645                 650                 655     


Asp Leu Met Thr Arg Tyr Gly Phe Asp Gly Val Met Ile Asp Trp Ser 
            660                 665                 670         


Gly Met Gln Ala Lys Asp Ser Asp Asn Phe Ile Lys Leu Leu Asp Lys 
        675                 680                 685             


Phe Asp Glu Asn Tyr Asn Ile Pro Ala Ile Ser Asn Tyr Val Asp Phe 
    690                 695                 700                 


Met Asn Val Leu Ser Leu Asp Tyr Thr Gly Ser Trp Ala His Thr Val 
705                 710                 715                 720 


Gly His Ala Ser Pro Phe Pro Glu Gln Leu Lys Thr Leu Glu Ala Tyr 
                725                 730                 735     


His Lys Arg Gly Ala Pro Arg His Lys Met Val Met Ala Val Pro Phe 
            740                 745                 750         


Tyr Ala Arg Thr Trp Ile Leu Glu Lys Met Asn Lys Gln Asp Ile Gly 
        755                 760                 765             


Asp Lys Ala Ser Gly Pro Gly Pro Arg Gly Gln Phe Thr Gln Thr Asp 
    770                 775                 780                 


Gly Phe Leu Ser Tyr Asn Glu Leu Cys Val Gln Ile Gln Ala Glu Thr 
785                 790                 795                 800 


Asn Ala Phe Thr Ile Thr Arg Asp His Asp Asn Thr Ala Ile Tyr Ala 
                805                 810                 815     


Val Tyr Val His Ser Asn His Ala Glu Trp Ile Ser Phe Glu Asp Arg 
            820                 825                 830         


His Thr Leu Gly Glu Lys Ala Lys Asn Ile Thr Gln Gln Gly Tyr Ala 
        835                 840                 845             


Gly Met Ser Val Tyr Thr Leu Ser Asn Glu Asp Val His Gly Val Cys 
    850                 855                 860                 


Gly Asp Lys Asn Pro Leu Leu His Ala Ile Gln Ser Asn Tyr Tyr His 
865                 870                 875                 880 


Gly Val Val Thr Glu Pro Thr Val Val Thr Leu Pro Pro Val Thr His 
                885                 890                 895     


Thr Thr Glu His Val Thr Asp Ile Pro Gly Val Phe His Cys His Glu 
            900                 905                 910         


Glu Gly Phe Phe Arg Asp Lys Thr Tyr Cys Ala Thr Tyr Tyr Glu Cys 
        915                 920                 925             


Lys Lys Gly Asp Phe Gly Leu Glu Lys Thr Val His His Cys Ala Asn 
    930                 935                 940                 


His Leu Gln Ala Phe Asp Glu Val Ser Arg Thr Cys Ile Asp His Thr 
945                 950                 955                 960 


Lys Ile Pro Gly Cys 
                965 


<210>  206
<211>  965
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  206

Ser Ile Lys Arg Asp His Asn Asp Tyr Ser Lys Asn Pro Met Arg Ile 
1               5                   10                  15      


Val Cys Tyr Val Gly Thr Trp Ser Val Tyr His Lys Val Asp Pro Tyr 
            20                  25                  30          


Thr Ile Glu Asp Ile Asp Pro Phe Lys Cys Thr His Leu Met Tyr Gly 
        35                  40                  45              


Phe Ala Lys Ile Asp Glu Tyr Lys Tyr Thr Ile Gln Val Phe Asp Pro 
    50                  55                  60                  


Tyr Gln Asp Asp Asn His Asn Ser Trp Glu Lys Arg Gly Tyr Glu Arg 
65                  70                  75                  80  


Phe Asn Asn Leu Arg Leu Lys Asn Pro Glu Leu Thr Thr Met Ile Ser 
                85                  90                  95      


Leu Gly Gly Trp Tyr Glu Gly Ser Glu Lys Tyr Ser Asp Met Ala Ala 
            100                 105                 110         


Asn Pro Thr Tyr Arg Gln Gln Phe Ile Gln Ser Val Leu Asp Phe Leu 
        115                 120                 125             


Gln Glu Tyr Lys Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly 
    130                 135                 140                 


Ser Arg Leu Gly Asn Pro Lys Ile Asp Lys Gln Asn Tyr Leu Ala Leu 
145                 150                 155                 160 


Val Arg Glu Leu Lys Asp Ala Phe Glu Pro His Gly Tyr Leu Leu Thr 
                165                 170                 175     


Ala Ala Val Ser Pro Gly Lys Asp Lys Ile Asp Arg Ala Tyr Asp Ile 
            180                 185                 190         


Lys Glu Leu Asn Lys Leu Phe Asp Trp Met Asn Val Met Thr Tyr Asp 
        195                 200                 205             


Tyr His Gly Gly Trp Glu Asn Phe Tyr Gly His Asn Ala Pro Leu Tyr 
    210                 215                 220                 


Lys Arg Pro Asp Glu Thr Asp Glu Leu His Thr Tyr Phe Asn Val Asn 
225                 230                 235                 240 


Tyr Thr Met His Tyr Tyr Leu Asn Asn Gly Ala Thr Arg Asp Lys Leu 
                245                 250                 255     


Val Met Gly Val Pro Phe Tyr Gly Arg Ala Trp Ser Ile Glu Asp Arg 
            260                 265                 270         


Ser Lys Leu Lys Leu Gly Asp Pro Ala Lys Gly Met Ser Pro Pro Gly 
        275                 280                 285             


Phe Ile Ser Gly Glu Glu Gly Val Leu Ser Tyr Ile Glu Leu Cys Gln 
    290                 295                 300                 


Leu Phe Gln Lys Glu Glu Trp His Ile Gln Tyr Asp Glu Tyr Tyr Asn 
305                 310                 315                 320 


Ala Pro Tyr Gly Tyr Asn Asp Lys Ile Trp Val Gly Tyr Asp Asp Leu 
                325                 330                 335     


Ala Ser Ile Ser Cys Lys Leu Ala Phe Leu Lys Glu Leu Gly Val Ser 
            340                 345                 350         


Gly Val Met Val Trp Ser Leu Glu Asn Asp Asp Phe Lys Gly His Cys 
        355                 360                 365             


Gly Pro Lys Asn Pro Leu Leu Asn Lys Val His Asn Met Ile Asn Gly 
    370                 375                 380                 


Asp Glu Lys Asn Ser Phe Glu Cys Ile Leu Gly Pro Ser Thr Thr Thr 
385                 390                 395                 400 


Pro Thr Pro Thr Thr Thr Pro Thr Thr Pro Thr Thr Thr Pro Thr Thr 
                405                 410                 415     


Pro Ser Pro Thr Thr Pro Thr Thr Thr Pro Ser Pro Thr Thr Pro Thr 
            420                 425                 430         


Thr Thr Pro Ser Pro Thr Thr Pro Thr Thr Thr Pro Ser Pro Thr Thr 
        435                 440                 445             


Pro Thr Pro Thr Thr Pro Thr Pro Ala Pro Thr Thr Ser Thr Pro Ser 
    450                 455                 460                 


Pro Thr Thr Thr Glu His Thr Ser Glu Thr Pro Lys Tyr Thr Thr Tyr 
465                 470                 475                 480 


Val Asp Gly His Leu Ile Lys Cys Tyr Lys Glu Gly Asp Ile Pro His 
                485                 490                 495     


Pro Thr Asn Ile His Lys Tyr Leu Val Cys Glu Phe Val Asn Gly Gly 
            500                 505                 510         


Trp Trp Val His Ile Met Pro Cys Pro Pro Gly Thr Ile Trp Cys Gln 
        515                 520                 525             


Glu Lys Leu Thr Cys Ile Gly Glu Gly Pro Gly Pro Gly Ser Asn Ile 
    530                 535                 540                 


Arg Pro Asn Val Ala Thr Leu Glu Pro Lys Thr Val Cys Tyr Tyr Glu 
545                 550                 555                 560 


Ser Trp Val His Trp Arg Gln Gly Glu Gly Lys Met Asp Pro Glu Asp 
                565                 570                 575     


Ile Asp Thr Ser Leu Cys Thr His Ile Val Tyr Ser Tyr Phe Gly Ile 
            580                 585                 590         


Asp Ala Ala Thr His Glu Ile Lys Leu Leu Asp Glu Tyr Leu Met Lys 
        595                 600                 605             


Asp Leu His Asp Met Glu His Phe Thr Gln His Lys Gly Asn Ala Lys 
    610                 615                 620                 


Ala Met Ile Ala Val Gly Gly Ser Thr Met Ser Asp Gln Phe Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Val Glu His Tyr Arg Glu Thr Phe Val Val Ser Thr Val 
                645                 650                 655     


Asp Leu Met Thr Arg Tyr Gly Phe Asp Gly Val Met Ile Asp Trp Ser 
            660                 665                 670         


Gly Met Gln Ala Lys Asp Ser Asp Asn Phe Ile Lys Leu Leu Asp Lys 
        675                 680                 685             


Phe Asp Glu Asn Tyr Asn Ile Pro Ala Ile Ser Asn Tyr Val Asp Phe 
    690                 695                 700                 


Met Asn Val Leu Ser Leu Asp Tyr Thr Gly Ser Trp Ala His Thr Val 
705                 710                 715                 720 


Gly His Ala Ser Pro Phe Pro Glu Gln Leu Lys Thr Leu Glu Ala Tyr 
                725                 730                 735     


His Lys Arg Gly Ala Pro Arg His Lys Met Val Met Ala Val Pro Phe 
            740                 745                 750         


Tyr Ala Arg Thr Trp Ile Leu Glu Lys Met Asn Lys Gln Asp Ile Gly 
        755                 760                 765             


Asp Lys Ala Ser Gly Pro Gly Pro Arg Gly Gln Phe Thr Gln Thr Asp 
    770                 775                 780                 


Gly Phe Leu Ser Tyr Asn Glu Leu Cys Val Gln Ile Gln Ala Glu Thr 
785                 790                 795                 800 


Asn Ala Phe Thr Ile Thr Arg Asp His Asp Asn Thr Ala Ile Tyr Ala 
                805                 810                 815     


Val Tyr Val His Ser Asn His Ala Glu Trp Ile Ser Phe Glu Asp Arg 
            820                 825                 830         


His Thr Leu Gly Glu Lys Ala Lys Asn Ile Thr Gln Gln Gly Tyr Ala 
        835                 840                 845             


Gly Met Ser Val Tyr Thr Leu Ser Asn Glu Asp Val His Gly Val Cys 
    850                 855                 860                 


Gly Asp Lys Asn Pro Leu Leu His Ala Ile Gln Ser Asn Tyr Tyr His 
865                 870                 875                 880 


Gly Val Val Thr Glu Pro Thr Val Val Thr Leu Pro Pro Val Thr His 
                885                 890                 895     


Thr Thr Glu His Val Thr Asp Ile Pro Gly Val Phe His Cys His Glu 
            900                 905                 910         


Glu Gly Phe Phe Arg Asp Lys Thr Tyr Cys Ala Thr Tyr Tyr Glu Cys 
        915                 920                 925             


Lys Lys Gly Asp Phe Gly Leu Glu Lys Thr Val His His Cys Ala Asn 
    930                 935                 940                 


His Leu Gln Ala Phe Asp Glu Val Ser Arg Thr Cys Ile Asp His Thr 
945                 950                 955                 960 


Lys Ile Pro Gly Cys 
                965 


<210>  207
<211>  134
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  207

Ile Ile Tyr Pro Gly Thr Leu Trp Cys Gly His Gly Asn Lys Ser Ser 
1               5                   10                  15      


Gly Pro Asn Glu Leu Gly Arg Phe Lys His Thr Asp Ala Cys Cys Arg 
            20                  25                  30          


Thr His Asp Met Cys Pro Asp Val Met Ser Ala Gly Glu Ser Lys His 
        35                  40                  45              


Gly Leu Thr Asn Thr Ala Ser His Thr Arg Leu Ser Cys Asp Cys Asp 
    50                  55                  60                  


Asp Lys Phe Tyr Asp Cys Leu Lys Asn Ser Ala Asp Thr Ile Ser Ser 
65                  70                  75                  80  


Tyr Phe Val Gly Lys Met Tyr Phe Asn Leu Ile Asp Thr Lys Cys Tyr 
                85                  90                  95      


Lys Leu Glu His Pro Val Thr Gly Cys Gly Glu Arg Thr Glu Gly Arg 
            100                 105                 110         


Cys Leu His Tyr Thr Val Asp Lys Ser Lys Pro Lys Val Tyr Gln Trp 
        115                 120                 125             


Phe Asp Leu Arg Lys Tyr 
    130                 


<210>  208
<211>  349
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  208

Pro Asp Asn Asn Lys Thr Val Arg Glu Phe Asn Val Tyr Trp Asn Val 
1               5                   10                  15      


Pro Thr Phe Met Cys His Lys Tyr Gly Leu Arg Phe Glu Glu Val Ser 
            20                  25                  30          


Glu Lys Tyr Gly Ile Leu Gln Asn Trp Met Asp Lys Phe Arg Gly Glu 
        35                  40                  45              


Glu Ile Ala Ile Leu Tyr Asp Pro Gly Met Phe Pro Ala Leu Leu Lys 
    50                  55                  60                  


Asp Pro Asn Gly Asn Val Val Ala Arg Asn Gly Gly Val Pro Gln Leu 
65                  70                  75                  80  


Gly Asn Leu Thr Lys His Leu Gln Val Phe Arg Asp His Leu Ile Asn 
                85                  90                  95      


Gln Ile Pro Asp Lys Ser Phe Pro Gly Val Gly Val Ile Asp Phe Glu 
            100                 105                 110         


Ser Trp Arg Pro Ile Phe Arg Gln Asn Trp Ala Ser Leu Gln Pro Tyr 
        115                 120                 125             


Lys Lys Leu Ser Val Glu Val Val Arg Arg Glu His Pro Phe Trp Asp 
    130                 135                 140                 


Asp Gln Arg Val Glu Gln Glu Ala Lys Arg Arg Phe Glu Lys Tyr Gly 
145                 150                 155                 160 


Gln Leu Phe Met Glu Glu Thr Leu Lys Ala Ala Lys Arg Met Arg Pro 
                165                 170                 175     


Ala Ala Asn Trp Gly Tyr Tyr Ala Tyr Pro Tyr Cys Tyr Asn Leu Thr 
            180                 185                 190         


Pro Asn Gln Pro Ser Ala Gln Cys Glu Ala Thr Thr Met Gln Glu Asn 
        195                 200                 205             


Asp Lys Met Ser Trp Leu Phe Glu Ser Glu Asp Val Leu Leu Pro Ser 
    210                 215                 220                 


Val Tyr Leu Arg Trp Asn Leu Thr Ser Gly Glu Arg Val Gly Leu Val 
225                 230                 235                 240 


Gly Gly Arg Val Lys Glu Ala Leu Arg Ile Ala Arg Gln Met Thr Thr 
                245                 250                 255     


Ser Arg Lys Lys Val Leu Pro Tyr Tyr Trp Tyr Lys Tyr Gln Asp Arg 
            260                 265                 270         


Arg Asp Thr Asp Leu Ser Arg Ala Asp Leu Glu Ala Thr Leu Arg Lys 
        275                 280                 285             


Ile Thr Asp Leu Gly Ala Asp Gly Phe Ile Ile Trp Gly Ser Ser Asp 
    290                 295                 300                 


Asp Ile Asn Thr Lys Ala Lys Cys Leu Gln Phe Arg Glu Tyr Leu Asn 
305                 310                 315                 320 


Asn Glu Leu Gly Pro Ala Val Lys Arg Ile Ala Leu Asn Asn Asn Ala 
                325                 330                 335     


Asn Asp Arg Leu Thr Val Asp Val Ser Val Asp Gln Val 
            340                 345                 


<210>  209
<211>  373
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  209

Glu Leu Lys Gln Ile Asn Val Ile Phe Arg His Gly Asp Arg Ile Pro 
1               5                   10                  15      


Asp Glu Lys Asn Glu Met Tyr Pro Lys Asp Pro Tyr Leu Tyr Tyr Asp 
            20                  25                  30          


Phe Tyr Pro Leu Glu Arg Gly Glu Leu Thr Asn Ser Gly Lys Met Arg 
        35                  40                  45              


Glu Tyr Gln Leu Gly Gln Phe Leu Arg Glu Arg Tyr Gly Asp Phe Leu 
    50                  55                  60                  


Gly Asp Ile Tyr Thr Glu Glu Ser Val Ser Ala Leu Ser Ser Phe Tyr 
65                  70                  75                  80  


Asp Arg Thr Lys Met Ser Leu Gln Leu Val Leu Ala Ala Leu Tyr Pro 
                85                  90                  95      


Pro Asn Lys Leu Gln Gln Trp Asn Glu Asp Leu Asn Trp Gln Pro Ile 
            100                 105                 110         


Ala Thr Lys Tyr Leu Arg Arg Tyr Glu Asp Asn Ile Phe Leu Pro Glu 
        115                 120                 125             


Asp Cys Leu Leu Phe Thr Ile Glu Leu Asp Arg Val Leu Glu Ser Pro 
    130                 135                 140                 


Arg Gly Lys Tyr Glu Phe Ser Lys Tyr Asp Lys Leu Lys Lys Lys Leu 
145                 150                 155                 160 


Glu Glu Trp Thr Gly Lys Asn Ile Thr Thr Pro Trp Asp Tyr Tyr Tyr 
                165                 170                 175     


Ile Tyr His Thr Leu Val Ala Glu Gln Ser Tyr Gly Leu Thr Leu Pro 
            180                 185                 190         


Ser Trp Thr Asn Asn Ile Phe Pro Arg Gly Glu Leu Phe Asp Ala Thr 
        195                 200                 205             


Val Phe Thr Tyr Asn Ile Thr Asn Ser Thr Pro Leu Leu Lys Lys Leu 
    210                 215                 220                 


Tyr Gly Gly Pro Leu Leu Arg Ile Phe Thr Lys His Met Leu Asp Val 
225                 230                 235                 240 


Val Ser Gly Thr Gln Lys Lys Lys Arg Lys Ile Tyr Leu Phe Ser Gly 
                245                 250                 255     


His Glu Ser Asn Ile Ala Ser Val Leu His Ala Leu Gln Leu Tyr Tyr 
            260                 265                 270         


Pro His Val Pro Glu Tyr Ser Ser Ser Ile Ile Met Glu Leu His Asn 
        275                 280                 285             


Ile Glu Gly Thr His Tyr Val Lys Ile Val Tyr Tyr Leu Gly Ile Pro 
    290                 295                 300                 


Ser Glu Ala Arg Glu Leu Gln Leu Pro Gly Cys Glu Val Leu Cys Pro 
305                 310                 315                 320 


Leu Tyr Lys Tyr Leu Gln Leu Ile Glu Asn Val Ile Pro Ser Asn Glu 
                325                 330                 335     


Glu Leu Ile Cys Asp Lys Arg Phe Val Asp Glu Ser Ala Asn Asn Leu 
            340                 345                 350         


Ser Ile Glu Glu Leu Asp Phe Val Lys Leu Asn Leu Ile Arg Ile Ala 
        355                 360                 365             


Gly Thr Glu Asn Lys 
    370             


<210>  210
<211>  752
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  210

Lys Ser Val Pro Arg Val Ile Asp Gln Asp Leu Glu Arg Tyr Glu Pro 
1               5                   10                  15      


Leu Glu Glu Glu Asp His Arg Gly Ala Arg Val Pro Phe Asn Leu Glu 
            20                  25                  30          


Glu Thr Tyr Asp Gln Ser Phe Arg Ala Asn Ser Phe Asn Gly Thr Trp 
        35                  40                  45              


Lys Thr Asp Arg Glu Ile Leu Tyr Ser Asp Asn Tyr Val Gly Asp Ile 
    50                  55                  60                  


Arg Leu Phe Asp Val Thr Thr Gly Ser Gly Thr Val Leu Leu Asp Ser 
65                  70                  75                  80  


Ser Val Thr Ala Asp Phe Asp Lys Ala Ser Val Met Phe Ser Phe Asp 
                85                  90                  95      


Asn Ser His Val Ala Ile Gly His Asp Tyr Val Asn Gly Phe Arg Tyr 
            100                 105                 110         


Ser Ile His Gln Lys Cys Thr Val Tyr Asn Ile Lys Ser Arg Thr Phe 
        115                 120                 125             


Thr Asp Ile Ala Asn Gly Asp Arg Ile Pro Leu Phe Lys Trp Ser Pro 
    130                 135                 140                 


Thr Arg Asn Ala Leu Ile Tyr Val His Lys Asn Asp Ile Tyr Tyr Gln 
145                 150                 155                 160 


Val Phe Phe Glu Gly Gly Ser Asp Thr Arg Arg Ile Thr Asn Thr Gly 
                165                 170                 175     


Val Pro Asp Ile Val Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu 
            180                 185                 190         


Glu Val Leu Gly Ser Pro Val Ala Phe Trp Ile Ser Pro Asp Gly Arg 
        195                 200                 205             


His Leu Ala Phe Ala Thr Phe Asn Asp Thr Asn Val Arg Asp Ile Val 
    210                 215                 220                 


Ile Ser Lys Tyr Gly Ser Pro Gly Asn Ser Arg Asp Gln Tyr Pro Asn 
225                 230                 235                 240 


Glu Ile Arg Ile Lys Tyr Pro Lys Ala Gly Thr Thr Asn Pro Phe Val 
                245                 250                 255     


Ser Leu Ser Val Ile Asp Leu His Asp Pro Ser Ser Lys Leu Ile Asp 
            260                 265                 270         


Leu Pro Pro Pro Val Asp Val Val Gly Ala Asp Asn Val Leu Tyr Thr 
        275                 280                 285             


Ala Asn Trp Arg Arg Asp Gly Glu Ile Val Ala Thr Trp Thr Asn Arg 
    290                 295                 300                 


Val Gln Asn Lys Ala Gln Leu Val Leu Tyr Asp Thr Lys Gly Asn Ala 
305                 310                 315                 320 


Asn Asn Ile Tyr Tyr Glu Glu Glu Thr Glu Gly Trp Leu Arg Ile Gln 
                325                 330                 335     


Pro Pro Leu Tyr His Asp Arg Tyr Val Ile Val Ala Lys Leu Gln Asp 
            340                 345                 350         


Ser Gly Thr Lys Ala Gly Arg Phe Leu His Ala Thr Arg Leu Glu Tyr 
        355                 360                 365             


Arg Asn Gly Ala Leu Val Asp Glu Thr Asp Leu Thr Pro Gly Thr Cys 
    370                 375                 380                 


Glu Val Ile Ser Leu Leu Leu Val Asp His Ala Arg Ala Arg Leu Tyr 
385                 390                 395                 400 


Tyr Leu Gly Thr Glu Leu Gly Lys Pro Ser His Lys Asn Leu Tyr Ser 
                405                 410                 415     


Val Gln Leu Ser Gly Asn Glu Pro Pro Val Cys Leu Ser Cys Asp Val 
            420                 425                 430         


Leu Thr Pro Glu Gly Asn Arg Cys Thr Tyr Ala Tyr Ala Tyr Phe Ser 
        435                 440                 445             


Thr Asn Gly Ser His Tyr Ala Leu Tyr Cys Ala Gly Pro Asp Pro Val 
    450                 455                 460                 


Phe Ile Ala Ile Val Asn Ala Asn His Arg Gln Ile Ser Ile Trp Glu 
465                 470                 475                 480 


Glu Asn Arg Ser Leu Arg Arg Lys Leu Ala Ala Arg Thr Gln Pro Ile 
                485                 490                 495     


Val Lys Asn Phe Asn Val Asn Ala Asn Gly Tyr Thr Asn Lys Val Lys 
            500                 505                 510         


Leu Tyr Leu Pro Pro Asp Phe Asp Glu Thr Lys Lys Tyr Pro Leu Leu 
        515                 520                 525             


Ile Thr Val Tyr Ala Gly Pro Asn Thr Ile Arg Ile Thr Glu Glu Ala 
    530                 535                 540                 


Thr Tyr Gly Phe Glu Ser Tyr Ile Val Thr Asn Arg Ser Val Ile Tyr 
545                 550                 555                 560 


Gly Arg Ile Asp Gly Arg Gly Ser Ala Tyr Lys Gly Ser Lys Met Leu 
                565                 570                 575     


Phe Glu Ile Tyr Arg Arg Leu Gly Thr Val Glu Ile Glu Asp Gln Ile 
            580                 585                 590         


Ile Ile Thr Arg Thr Leu Gln Glu Lys Tyr Ser Trp Ile Asp Ser Asn 
        595                 600                 605             


Arg Thr Gly Ile Trp Gly Trp Ser Tyr Gly Gly Phe Ser Ala Ala Met 
    610                 615                 620                 


Val Leu Ala Thr Asp Ala Glu Ser Val Phe Lys Cys Gly Ile Ser Val 
625                 630                 635                 640 


Ala Pro Val Thr Ser Trp Ile Tyr Tyr Asp Ser Leu Tyr Thr Glu Arg 
                645                 650                 655     


Phe Met Gly Leu Pro Thr Pro Glu Asp Asn Gln Ser Gly Tyr Asn Asp 
            660                 665                 670         


Thr Asp Val Ser Arg Arg Val Glu Gly Met Arg Gly Lys Lys Tyr Met 
        675                 680                 685             


Leu Ile His Gly Thr Ala Asp Asp Asn Val His Tyr Gln Gln Thr Met 
    690                 695                 700                 


Met Leu Asn Lys Ala Leu Val Asn Ser Asp Ile Met Phe Gln Gln Gln 
705                 710                 715                 720 


Thr Tyr Thr Asp Glu Ala His Ala Leu Gly Asn Val Phe Pro His Leu 
                725                 730                 735     


Tyr His Thr Thr Asp Arg Phe Trp Ala Asn Cys Leu Gly Tyr Ser His 
            740                 745                 750         


<210>  211
<211>  204
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  211

Phe Pro Gly Ala His Asp Glu Asp Ser Lys Glu Glu Arg Lys Asn Val 
1               5                   10                  15      


Asp Thr Val Leu Val Leu Pro Ser Ile Glu Arg Asp Gln Met Met Ala 
            20                  25                  30          


Ala Thr Phe Asp Phe Pro Ser Leu Ser Phe Glu Asp Ser Asp Glu Gly 
        35                  40                  45              


Ser Asn Trp Asn Trp Asn Thr Leu Leu Arg Pro Asn Phe Leu Asp Gly 
    50                  55                  60                  


Trp Tyr Gln Thr Leu Gln Ser Ala Ile Ser Ala His Met Lys Lys Val 
65                  70                  75                  80  


Arg Glu Gln Met Ala Gly Ile Leu Ser Arg Ile Pro Glu Gln Gly Val 
                85                  90                  95      


Val Asn Trp Asn Lys Ile Pro Glu Gly Ala Asn Thr Thr Ser Thr Thr 
            100                 105                 110         


Lys Ile Ile Asp Gly His Val Val Thr Ile Asn Glu Thr Thr Tyr Thr 
        115                 120                 125             


Asp Gly Ser Asp Asp Tyr Ser Thr Leu Ile Arg Val Arg Val Ile Asp 
    130                 135                 140                 


Val Arg Pro Gln Asn Glu Thr Ile Leu Thr Thr Val Ser Ser Glu Ala 
145                 150                 155                 160 


Asp Ser Asp Val Thr Thr Leu Pro Thr Leu Ile Gly Lys Asn Glu Thr 
                165                 170                 175     


Ser Thr Gln Ser Ser Arg Ser Val Glu Ser Val Glu Asp Phe Asp Asn 
            180                 185                 190         


Glu Ile Pro Lys Asn Gln Gly Asp Val Leu Thr Ala 
        195                 200                 


<210>  212
<211>  300
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  212

Gly Pro Lys Cys Pro Phe Asn Ser Asp Thr Val Ser Ile Ile Ile Glu 
1               5                   10                  15      


Thr Arg Glu Asn Arg Asn Arg Asp Leu Tyr Thr Leu Gln Thr Leu Gln 
            20                  25                  30          


Asn His Pro Glu Phe Lys Lys Lys Thr Ile Thr Arg Pro Val Val Phe 
        35                  40                  45              


Ile Thr His Gly Phe Thr Ser Ser Ala Ser Glu Thr Asn Phe Ile Asn 
    50                  55                  60                  


Leu Ala Lys Ala Leu Val Asp Lys Asp Asn Tyr Met Val Ile Ser Ile 
65                  70                  75                  80  


Asp Trp Gln Thr Ala Ala Cys Thr Asn Glu Ala Ala Gly Leu Lys Tyr 
                85                  90                  95      


Leu Tyr Tyr Pro Thr Ala Ala Arg Asn Thr Arg Leu Val Gly Gln Tyr 
            100                 105                 110         


Ile Ala Thr Ile Thr Gln Lys Leu Val Lys His Tyr Lys Ile Ser Met 
        115                 120                 125             


Ala Asn Ile Arg Leu Ile Gly His Ser Leu Gly Ala His Ala Ser Gly 
    130                 135                 140                 


Phe Ala Gly Lys Lys Val Gln Glu Leu Lys Leu Gly Lys Tyr Ser Glu 
145                 150                 155                 160 


Ile Ile Gly Leu Asp Pro Ala Arg Pro Ser Phe Asp Ser Asn His Cys 
                165                 170                 175     


Ser Glu Arg Leu Cys Glu Thr Asp Ala Glu Tyr Val Gln Ile Ile His 
            180                 185                 190         


Thr Ser Asn Tyr Leu Gly Thr Glu Lys Thr Leu Gly Thr Val Asp Phe 
        195                 200                 205             


Tyr Met Asn Asn Gly Lys Asn Gln Pro Gly Cys Gly Arg Phe Phe Ser 
    210                 215                 220                 


Glu Val Cys Ser His Ser Arg Ala Val Ile Tyr Met Ala Glu Cys Ile 
225                 230                 235                 240 


Lys His Glu Cys Cys Leu Ile Gly Ile Pro Lys Ser Lys Ser Ser Gln 
                245                 250                 255     


Pro Ile Ser Ser Cys Thr Lys Gln Glu Cys Val Cys Val Gly Leu Asn 
            260                 265                 270         


Ala Lys Lys Tyr Pro Ser Arg Gly Ser Phe Tyr Val Pro Val Glu Ser 
        275                 280                 285             


Thr Ala Pro Phe Cys Asn Asn Lys Gly Lys Ile Ile 
    290                 295                 300 


<210>  213
<211>  331
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  213

Ser Glu Arg Pro Lys Arg Val Phe Asn Ile Tyr Trp Asn Val Pro Thr 
1               5                   10                  15      


Phe Met Cys His Gln Tyr Asp Leu Tyr Phe Asp Glu Val Thr Asn Phe 
            20                  25                  30          


Asn Ile Lys Arg Asn Ser Lys Asp Asp Phe Gln Gly Asp Lys Ile Ala 
        35                  40                  45              


Ile Phe Tyr Asp Pro Gly Glu Phe Pro Ala Leu Leu Ser Leu Lys Asp 
    50                  55                  60                  


Gly Lys Tyr Lys Lys Arg Asn Gly Gly Val Pro Gln Glu Gly Asn Ile 
65                  70                  75                  80  


Thr Ile His Leu Gln Lys Phe Ile Glu Asn Leu Asp Lys Ile Tyr Pro 
                85                  90                  95      


Asn Arg Asn Phe Ser Gly Ile Gly Val Ile Asp Phe Glu Arg Trp Arg 
            100                 105                 110         


Pro Ile Phe Arg Gln Asn Trp Gly Asn Met Lys Ile His Lys Asn Phe 
        115                 120                 125             


Ser Ile Asp Leu Val Arg Asn Glu His Pro Thr Trp Asn Lys Lys Met 
    130                 135                 140                 


Ile Glu Leu Glu Ala Ser Lys Arg Phe Glu Lys Tyr Ala Arg Phe Phe 
145                 150                 155                 160 


Met Glu Glu Thr Leu Lys Leu Ala Lys Lys Thr Arg Lys Gln Ala Asp 
                165                 170                 175     


Trp Gly Tyr Tyr Gly Tyr Pro Tyr Cys Phe Asn Met Ser Pro Asn Asn 
            180                 185                 190         


Leu Val Pro Glu Cys Asp Val Thr Ala Met His Glu Asn Asp Lys Met 
        195                 200                 205             


Ser Trp Leu Phe Asn Asn Gln Asn Val Leu Leu Pro Ser Val Tyr Val 
    210                 215                 220                 


Arg Gln Glu Leu Thr Pro Asp Gln Arg Ile Gly Leu Val Gln Gly Arg 
225                 230                 235                 240 


Val Lys Glu Ala Val Arg Ile Ser Asn Asn Leu Lys His Ser Pro Lys 
                245                 250                 255     


Val Leu Ser Tyr Trp Trp Tyr Val Tyr Gln Asp Glu Thr Asn Thr Phe 
            260                 265                 270         


Leu Thr Glu Thr Asp Val Lys Lys Thr Phe Gln Glu Ile Val Ile Asn 
        275                 280                 285             


Gly Gly Asp Gly Ile Ile Ile Trp Gly Ser Ser Ser Asp Val Asn Ser 
    290                 295                 300                 


Leu Ser Lys Cys Lys Arg Leu Gln Asp Tyr Leu Leu Thr Val Leu Gly 
305                 310                 315                 320 


Pro Ile Ala Ile Asn Val Thr Glu Ala Val Asn 
                325                 330     


<210>  214
<211>  751
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  214

Arg Val Ile Asp Lys Asp Asn Ser Asp Arg Ile Val Lys Thr Gln Asn 
1               5                   10                  15      


Asp Gln Asn Leu Ser Lys Val Pro Phe Asn Leu Glu Glu Thr Tyr Thr 
            20                  25                  30          


Ala Asp Phe Leu Ala Tyr Val Phe Asn Gly Thr Trp Thr Ser Asp Thr 
        35                  40                  45              


Thr Ile Val Tyr Thr Asp Arg Arg Thr Gly Asp Ile Leu Gln Phe Asp 
    50                  55                  60                  


Val Ile Lys Gln Arg Ser Thr Leu Ile Val Asp Ser Ser Val Met Asp 
65                  70                  75                  80  


Ala Tyr Ile Val Ser Asn Tyr Val Leu Ser Pro Lys Gly Arg Tyr Leu 
                85                  90                  95      


Leu Ile Gly Tyr Asp Leu Lys Lys Gly Tyr Arg Tyr Ser Thr Phe Met 
            100                 105                 110         


Arg Tyr Val Ile Tyr Asp Ile Glu His Arg Ala Tyr His Lys Ile Gly 
        115                 120                 125             


Asn Asp Met His Ile Ala Leu Ala Lys Trp Ala Pro Leu Thr Asp Asp 
    130                 135                 140                 


Leu Ile Tyr Ile Leu Asp Asn Asp Ile Tyr Tyr Met Arg Phe Ser Asn 
145                 150                 155                 160 


Asn Gly Phe Asn Asp Val Gln Arg Val Thr Tyr Asp Gly Ile Ser Gly 
                165                 170                 175     


Ile Val Tyr Asn Gly Val Pro Asp Trp Val Tyr Glu Glu Glu Val Leu 
            180                 185                 190         


Gln Asp Ser Ser Ala Ile Trp Phe Ser Pro Asp Gly Asn His Leu Ala 
        195                 200                 205             


Tyr Ala Ser Phe Asp Asp Arg Asn Val Gln Glu Ile Leu Tyr Leu His 
    210                 215                 220                 


Tyr Gly Glu Pro Gly Asn Leu Asp Asp Gln Tyr Pro Thr Glu Val Lys 
225                 230                 235                 240 


Ile Lys Tyr Pro Lys Val Gly Thr Leu Asn Pro Val Val Ser Leu Thr 
                245                 250                 255     


Leu Val Asp Leu His Asp Pro Thr Leu Asn Lys Ile Asp Leu Lys Ala 
            260                 265                 270         


Pro His Tyr Ala Val Gly Thr Asp Asn Leu Leu Tyr Asn Val Gln Trp 
        275                 280                 285             


Lys Asp Phe Asp His Val Val Val Thr Trp Ser Asn Arg Val Gln Asn 
    290                 295                 300                 


Lys Thr Glu Ile Val Trp Tyr Asn Met Tyr Gly Glu Ile Val Lys Thr 
305                 310                 315                 320 


Leu His Val Val Glu His Lys Gly Trp Leu Asp Ile Lys His Leu Phe 
                325                 330                 335     


Phe Tyr Lys Gly Ser Val Tyr Ile Arg Lys Leu Gln Pro Ser Gly Thr 
            340                 345                 350         


Lys Ala Gly Arg Phe His His Val Thr Arg Tyr Asp Glu Thr Phe Lys 
        355                 360                 365             


Gln Ser Pro Thr Gln Met Asp Leu Thr Pro Asp Ala Ile Glu Val Gln 
    370                 375                 380                 


Asn Ile Cys Thr Ile Asp Gln Ser Asn Gly Arg Ile Tyr Tyr Leu Ala 
385                 390                 395                 400 


Ser Gly Leu Gly Lys Pro Ser Gln Lys Asn Leu Tyr Ser Val Pro Ala 
                405                 410                 415     


Asp Gly Ser Glu Lys Pro Thr Cys Ile Ser Cys Asn Val Leu Thr Pro 
            420                 425                 430         


Glu Gly Asn Val Cys Thr Tyr Ala Asp Ala Ile Phe Ser Pro Leu Gly 
        435                 440                 445             


Gln Tyr Tyr Val Leu Val Cys His Gly Pro Asp Pro Ala Phe Val Ser 
    450                 455                 460                 


Ile Phe Asn Asn Ala His Gln Lys Val Tyr Ser Trp Glu Asn Asn Leu 
465                 470                 475                 480 


Ser Leu Arg Lys Lys Leu Ala Lys Arg His Leu Pro Leu Val Lys Asp 
                485                 490                 495     


Leu Asp Val Arg Ala Asn Gly Tyr Glu Ser Lys Val Arg Leu Phe Leu 
            500                 505                 510         


Pro His Asn Phe Asp Glu Ser Lys Ser Tyr Pro Met Leu Val Asn Val 
        515                 520                 525             


Tyr Ala Gly Pro Asn Thr Leu Lys Ile Ile Asp Ala Ala Ser Tyr Gly 
    530                 535                 540                 


His Gln Val Tyr Met Thr Thr Asn Arg Ser Val Ile Tyr Ala Tyr Ile 
545                 550                 555                 560 


Asp Gly Arg Gly Ser Ser Asn Lys Gly Ser Lys Met Leu Phe Ser Ile 
                565                 570                 575     


Tyr Arg Lys Leu Gly Thr Val Glu Val Glu Asp Gln Ile Thr Val Thr 
            580                 585                 590         


Arg Gln Leu Gln Glu Met Phe Pro Trp Ile Asp Ser Lys Arg Thr Gly 
        595                 600                 605             


Val Trp Gly Trp Ser Tyr Gly Gly Phe Ser Thr Ala Met Ile Leu Ala 
    610                 615                 620                 


Lys Asp Thr Ser Phe Val Phe Lys Cys Gly Ile Ala Ile Ala Pro Val 
625                 630                 635                 640 


Ser Ser Trp Ile Tyr Tyr Asp Ser Ile Tyr Thr Glu Arg Phe Met Gly 
                645                 650                 655     


Phe Pro Thr Pro Glu Asp Asn Leu Ser Gly Tyr Asn Glu Thr Asp Val 
            660                 665                 670         


Ser Arg Arg Val Glu Asp Ile Arg Gly Lys Lys Phe Met Leu Ile His 
        675                 680                 685             


Gly Ser Gly Asp Asp Asn Val His Tyr Gln Gln Ser Leu Ala Leu Ala 
    690                 695                 700                 


Lys Ala Leu Glu Lys Ala Asp Val Met Phe Glu Gln Ile Thr Tyr Thr 
705                 710                 715                 720 


Asp Glu Ala His Ala Leu Phe Gly Val Leu Pro His Leu Tyr His Thr 
                725                 730                 735     


Met Asp Arg Phe Trp Ser Asp Cys Phe Ser Leu Ser His Ala His 
            740                 745                 750     


<210>  215
<211>  204
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  215

Asn Asn Tyr Cys Lys Ile Lys Cys Leu Lys Gly Gly Val His Thr Ala 
1               5                   10                  15      


Cys Lys Tyr Gly Ser Leu Lys Pro Asn Cys Gly Asn Lys Val Val Val 
            20                  25                  30          


Ser Tyr Gly Leu Thr Lys Gln Glu Lys Gln Asp Ile Leu Lys Glu His 
        35                  40                  45              


Asn Asp Phe Arg Gln Lys Ile Ala Arg Gly Leu Glu Thr Arg Gly Asn 
    50                  55                  60                  


Pro Gly Pro Gln Pro Pro Ala Lys Asn Met Lys Asn Leu Val Trp Asn 
65                  70                  75                  80  


Asp Glu Leu Ala Tyr Val Ala Gln Val Trp Ala Asn Gln Cys Gln Tyr 
                85                  90                  95      


Gly His Asp Thr Cys Arg Asp Val Ala Lys Tyr Gln Val Gly Gln Asn 
            100                 105                 110         


Val Ala Leu Thr Gly Ser Thr Ala Ala Lys Tyr Asp Asp Pro Val Lys 
        115                 120                 125             


Leu Val Lys Met Trp Glu Asp Glu Val Lys Asp Tyr Asn Pro Lys Lys 
    130                 135                 140                 


Lys Phe Ser Gly Asn Asp Phe Leu Lys Thr Gly His Tyr Thr Gln Met 
145                 150                 155                 160 


Val Trp Ala Asn Thr Lys Glu Val Gly Cys Gly Ser Ile Lys Tyr Ile 
                165                 170                 175     


Gln Glu Lys Trp His Lys His Tyr Leu Val Cys Asn Tyr Gly Pro Ser 
            180                 185                 190         


Gly Asn Phe Met Asn Glu Glu Leu Tyr Gln Thr Lys 
        195                 200                 


<210>  216
<211>  302
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  216

Gly Ile Thr Pro Asp Cys Thr Phe Asn Glu Lys Asp Ile Glu Leu His 
1               5                   10                  15      


Val Tyr Ser Arg Asp Lys Arg Asn Gly Ile Ile Leu Lys Lys Glu Ile 
            20                  25                  30          


Leu Lys Asn Tyr Asp Leu Phe Gln Lys Ser Gln Ile Ser His Gln Ile 
        35                  40                  45              


Ala Ile Leu Ile His Gly Phe Leu Ser Thr Gly Asn Asn Glu Asn Phe 
    50                  55                  60                  


Asp Ala Met Ala Lys Ala Leu Ile Glu Ile Asp Asn Phe Leu Val Ile 
65                  70                  75                  80  


Ser Val Asp Trp Lys Lys Gly Ala Cys Asn Ala Phe Ala Ser Thr Asn 
                85                  90                  95      


Asp Val Leu Gly Tyr Ser Gln Ala Val Gly Asn Thr Arg His Val Gly 
            100                 105                 110         


Lys Tyr Val Ala Asp Phe Thr Lys Leu Leu Val Glu Gln Tyr Lys Val 
        115                 120                 125             


Pro Met Ser Asn Ile Arg Leu Ile Gly His Ser Leu Gly Ala His Thr 
    130                 135                 140                 


Ser Gly Phe Ala Gly Lys Glu Val Gln Arg Leu Lys Leu Gly Lys Tyr 
145                 150                 155                 160 


Lys Glu Ile Ile Gly Leu Asp Pro Ala Gly Pro Ser Phe Leu Thr Asn 
                165                 170                 175     


Lys Cys Pro Asn Arg Leu Cys Glu Thr Asp Ala Glu Tyr Val Gln Ala 
            180                 185                 190         


Ile His Thr Ser Ala Ile Leu Gly Val Tyr Tyr Asn Val Gly Ser Val 
        195                 200                 205             


Asp Phe Tyr Val Asn Tyr Gly Lys Ser Gln Pro Gly Cys Ser Glu Pro 
    210                 215                 220                 


Ser Cys Ser His Thr Lys Ala Val Lys Tyr Leu Thr Glu Cys Ile Lys 
225                 230                 235                 240 


Arg Glu Cys Cys Leu Ile Gly Thr Pro Trp Lys Ser Tyr Phe Ser Thr 
                245                 250                 255     


Pro Lys Pro Ile Ser Gln Cys Lys Arg Asp Thr Cys Val Cys Val Gly 
            260                 265                 270         


Leu Asn Ala Gln Ser Tyr Pro Ala Lys Gly Ser Phe Tyr Val Pro Val 
        275                 280                 285             


Asp Lys Asp Ala Pro Tyr Cys His Asn Glu Gly Ile Lys Leu 
    290                 295                 300         


<210>  217
<211>  206
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  217

Asn Asp Tyr Cys Lys Ile Lys Cys Ser Ser Gly Val His Thr Val Cys 
1               5                   10                  15      


Gln Tyr Gly Glu Ser Thr Lys Pro Ser Lys Asn Cys Ala Gly Lys Leu 
            20                  25                  30          


Ile Lys Ser Val Gly Pro Thr Glu Glu Glu Lys Lys Leu Ile Val Glu 
        35                  40                  45              


Glu His Asn Arg Phe Arg Gln Lys Val Ala Lys Gly Leu Glu Thr Arg 
    50                  55                  60                  


Gly Asn Pro Gly Pro Gln Pro Ala Ala Ser Asn Met Asn Asn Leu Val 
65                  70                  75                  80  


Trp Asn Asp Glu Leu Ala Lys Ile Ala Gln Val Trp Ala Ser Gln Cys 
                85                  90                  95      


Gln Ile Leu Val His Asp Lys Cys Arg Asn Thr Glu Lys Tyr Gln Val 
            100                 105                 110         


Gly Gln Asn Ile Ala Tyr Ala Gly Ser Ser Asn His Phe Pro Ser Val 
        115                 120                 125             


Thr Lys Leu Ile Gln Leu Trp Glu Asn Glu Val Lys Asp Phe Asn Tyr 
    130                 135                 140                 


Asn Thr Gly Ile Thr Asn Lys Asn Phe Gly Lys Val Gly His Tyr Thr 
145                 150                 155                 160 


Gln Met Val Trp Gly Asn Thr Lys Glu Val Gly Cys Gly Ser Leu Lys 
                165                 170                 175     


Tyr Val Glu Lys Asn Met Gln Ile His Tyr Leu Ile Cys Asn Tyr Gly 
            180                 185                 190         


Pro Ala Gly Asn Tyr Leu Gly Gln Pro Ile Tyr Thr Lys Lys 
        195                 200                 205     


<210>  218
<211>  626
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  218

Met Arg Gly Arg Val Ser Pro Leu Met Leu Leu Leu Gly Ile Leu Val 
1               5                   10                  15      


Leu Ala Ser Val Ser Ala Thr His Ala Lys Ser Ser Pro Tyr Gln Lys 
            20                  25                  30          


Lys Thr Glu Asn Pro Cys Ala Gln Arg Cys Leu Gln Ser Cys Gln Gln 
        35                  40                  45              


Glu Pro Asp Asp Leu Lys Gln Lys Ala Cys Glu Ser Arg Cys Thr Lys 
    50                  55                  60                  


Leu Glu Tyr Asp Pro Arg Cys Val Tyr Asp Pro Arg Gly His Thr Gly 
65                  70                  75                  80  


Thr Thr Asn Gln Arg Ser Pro Pro Gly Glu Arg Thr Arg Gly Arg Gln 
                85                  90                  95      


Pro Gly Asp Tyr Asp Asp Asp Arg Arg Gln Pro Arg Arg Glu Glu Gly 
            100                 105                 110         


Gly Arg Trp Gly Pro Ala Gly Pro Arg Glu Arg Glu Arg Glu Glu Asp 
        115                 120                 125             


Trp Arg Gln Pro Arg Glu Asp Trp Arg Arg Pro Ser His Gln Gln Pro 
    130                 135                 140                 


Arg Lys Ile Arg Pro Glu Gly Arg Glu Gly Glu Gln Glu Trp Gly Thr 
145                 150                 155                 160 


Pro Gly Ser His Val Arg Glu Glu Thr Ser Arg Asn Asn Pro Phe Tyr 
                165                 170                 175     


Phe Pro Ser Arg Arg Phe Ser Thr Arg Tyr Gly Asn Gln Asn Gly Arg 
            180                 185                 190         


Ile Arg Val Leu Gln Arg Phe Asp Gln Arg Ser Arg Gln Phe Gln Asn 
        195                 200                 205             


Leu Gln Asn His Arg Ile Val Gln Ile Glu Ala Lys Pro Asn Thr Leu 
    210                 215                 220                 


Val Leu Pro Lys His Ala Asp Ala Asp Asn Ile Leu Val Ile Gln Gln 
225                 230                 235                 240 


Gly Gln Ala Thr Val Thr Val Ala Asn Gly Asn Asn Arg Lys Ser Phe 
                245                 250                 255     


Asn Leu Asp Glu Gly His Ala Leu Arg Ile Pro Ser Gly Phe Ile Ser 
            260                 265                 270         


Tyr Ile Leu Asn Arg His Asp Asn Gln Asn Leu Arg Val Ala Lys Ile 
        275                 280                 285             


Ser Met Pro Val Asn Thr Pro Gly Gln Phe Glu Asp Phe Phe Pro Ala 
    290                 295                 300                 


Ser Ser Arg Asp Gln Ser Ser Tyr Leu Gln Gly Phe Ser Arg Asn Thr 
305                 310                 315                 320 


Leu Glu Ala Ala Phe Asn Ala Glu Phe Asn Glu Ile Arg Arg Val Leu 
                325                 330                 335     


Leu Glu Glu Asn Ala Gly Gly Glu Gln Glu Glu Arg Gly Gln Arg Arg 
            340                 345                 350         


Trp Ser Thr Arg Ser Ser Glu Asn Asn Glu Gly Val Ile Val Lys Val 
        355                 360                 365             


Ser Lys Glu His Val Glu Glu Leu Thr Lys His Ala Lys Ser Val Ser 
    370                 375                 380                 


Lys Lys Gly Ser Glu Glu Glu Gly Asp Ile Thr Asn Pro Ile Asn Leu 
385                 390                 395                 400 


Arg Glu Gly Glu Pro Asp Leu Ser Asn Asn Phe Gly Lys Leu Phe Glu 
                405                 410                 415     


Val Lys Pro Asp Lys Lys Asn Pro Gln Leu Gln Asp Leu Asp Met Met 
            420                 425                 430         


Leu Thr Cys Val Glu Ile Lys Glu Gly Ala Leu Met Leu Pro His Phe 
        435                 440                 445             


Asn Ser Lys Ala Met Val Ile Val Val Val Asn Lys Gly Thr Gly Asn 
    450                 455                 460                 


Leu Glu Leu Val Ala Val Arg Lys Glu Gln Gln Gln Arg Gly Arg Arg 
465                 470                 475                 480 


Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Gly Ser Asn Arg Glu 
                485                 490                 495     


Val Arg Arg Tyr Thr Ala Arg Leu Lys Glu Gly Asp Val Phe Ile Met 
            500                 505                 510         


Pro Ala Ala His Pro Val Ala Ile Asn Ala Ser Ser Glu Leu His Leu 
        515                 520                 525             


Leu Gly Phe Gly Ile Asn Ala Glu Asn Asn His Arg Ile Phe Leu Ala 
    530                 535                 540                 


Gly Asp Lys Asp Asn Val Ile Asp Gln Ile Glu Lys Gln Ala Lys Asp 
545                 550                 555                 560 


Leu Ala Phe Pro Gly Ser Gly Glu Gln Val Glu Lys Leu Ile Lys Asn 
                565                 570                 575     


Gln Lys Glu Ser His Phe Val Ser Ala Arg Pro Gln Ser Gln Ser Gln 
            580                 585                 590         


Ser Pro Ser Ser Pro Glu Lys Glu Ser Pro Glu Lys Glu Asp Gln Glu 
        595                 600                 605             


Glu Glu Asn Gln Gly Gly Lys Gly Pro Leu Leu Ser Ile Leu Lys Ala 
    610                 615                 620                 


Phe Asn 
625     


<210>  219
<211>  169
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  219

Leu Thr Ile Leu Val Ala Pro Ala Leu Phe Leu Leu Ala Ala His Ala 
1               5                   10                  15      


Ser Ala Arg Gln Gln Trp Glu Leu Gln Gly Asp Arg Arg Cys Gln Ser 
            20                  25                  30          


Gln Leu Glu Arg Ala Asn Leu Arg Pro Cys Glu Gln His Leu Met Gln 
        35                  40                  45              


Lys Ile Gln Arg Asp Glu Asp Ser Tyr Gly Arg Asp Pro Tyr Ser Pro 
    50                  55                  60                  


Ser Gln Asp Pro Tyr Ser Pro Ser Gln Asp Pro Asp Arg Arg Asp Pro 
65                  70                  75                  80  


Tyr Ser Pro Ser Pro Tyr Asp Arg Arg Gly Ala Gly Ser Ser Gln His 
                85                  90                  95      


Gln Glu Arg Cys Cys Asn Glu Leu Asn Glu Phe Glu Asn Asn Gln Arg 
            100                 105                 110         


Cys Met Cys Glu Ala Leu Gln Gln Ile Met Glu Asn Gln Ser Asp Arg 
        115                 120                 125             


Leu Gln Gly Arg Gln Gln Glu Gln Gln Phe Lys Arg Glu Leu Arg Asn 
    130                 135                 140                 


Leu Pro Gln Gln Cys Gly Leu Arg Ala Pro Gln Arg Cys Asp Leu Glu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Arg Asp Arg Tyr 
                165                 


<210>  220
<211>  512
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  220

Met Ala Lys Leu Leu Ala Leu Ser Leu Cys Phe Cys Val Leu Val Leu 
1               5                   10                  15      


Gly Ala Ser Ser Val Thr Phe Arg Gln Gly Gly Glu Glu Asn Glu Cys 
            20                  25                  30          


Gln Phe Gln Arg Leu Asn Ala Gln Arg Pro Asp Asn Arg Ile Glu Ser 
        35                  40                  45              


Glu Gly Gly Tyr Ile Glu Thr Trp Asn Pro Asn Asn Gln Glu Phe Gln 
    50                  55                  60                  


Cys Ala Gly Val Ala Leu Ser Arg Thr Val Leu Arg Arg Asn Ala Leu 
65                  70                  75                  80  


Arg Arg Pro Phe Tyr Ser Asn Ala Pro Leu Glu Ile Tyr Val Gln Gln 
                85                  90                  95      


Gly Ser Gly Tyr Phe Gly Leu Ile Phe Pro Gly Cys Pro Ser Thr Tyr 
            100                 105                 110         


Glu Glu Pro Ala Gln Glu Gly Arg Arg Tyr Gln Ser Gln Lys Pro Ser 
        115                 120                 125             


Arg Arg Phe Gln Val Gly Gln Asp Asp Pro Ser Gln Gln Gln Gln Asp 
    130                 135                 140                 


Ser His Gln Lys Val His Arg Phe Asp Glu Gly Asp Leu Ile Ala Val 
145                 150                 155                 160 


Pro Thr Gly Val Ala Phe Trp Met Tyr Asn Asp Glu Asp Thr Asp Val 
                165                 170                 175     


Val Thr Val Thr Leu Ser Asp Thr Ser Ser Ile His Asn Gln Leu Asp 
            180                 185                 190         


Gln Phe Pro Arg Arg Phe Tyr Leu Ala Gly Asn Gln Glu Gln Glu Phe 
        195                 200                 205             


Leu Arg Tyr Gln Gln Gln Gln Gly Ser Arg Pro His Tyr Arg Gln Ile 
    210                 215                 220                 


Ser Pro Arg Val Arg Gly Asp Glu Gln Glu Asn Glu Gly Ser Asn Ile 
225                 230                 235                 240 


Phe Ser Gly Phe Ala Gln Glu Phe Leu Gln His Ala Phe Gln Val Asp 
                245                 250                 255     


Arg Gln Thr Val Glu Asn Leu Arg Gly Glu Asn Glu Arg Glu Glu Gln 
            260                 265                 270         


Gly Ala Ile Val Thr Val Lys Gly Gly Leu Arg Ile Leu Ser Pro Asp 
        275                 280                 285             


Glu Glu Asp Glu Ser Ser Arg Ser Pro Pro Asn Arg Arg Glu Glu Phe 
    290                 295                 300                 


Asp Glu Asp Arg Ser Arg Pro Gln Gln Arg Gly Lys Tyr Asp Glu Asn 
305                 310                 315                 320 


Arg Arg Gly Tyr Lys Asn Gly Ile Glu Glu Thr Ile Cys Ser Ala Ser 
                325                 330                 335     


Val Lys Lys Asn Leu Gly Arg Ser Ser Asn Pro Asp Ile Tyr Asn Pro 
            340                 345                 350         


Gln Ala Gly Ser Leu Arg Ser Val Asn Glu Leu Asp Leu Pro Ile Leu 
        355                 360                 365             


Gly Trp Leu Gly Leu Ser Ala Gln His Gly Thr Ile Tyr Arg Asn Ala 
    370                 375                 380                 


Met Phe Val Pro His Tyr Thr Leu Asn Ala His Thr Ile Val Val Ala 
385                 390                 395                 400 


Leu Asn Gly Arg Ala His Val Gln Val Val Asp Ser Asn Gly Asn Arg 
                405                 410                 415     


Val Tyr Asp Glu Glu Leu Gln Glu Gly His Val Leu Val Val Pro Gln 
            420                 425                 430         


Asn Phe Ala Val Ala Ala Lys Ala Gln Ser Glu Asn Tyr Glu Tyr Leu 
        435                 440                 445             


Ala Phe Lys Thr Asp Ser Arg Pro Ser Ile Ala Asn Gln Ala Gly Glu 
    450                 455                 460                 


Asn Ser Ile Ile Asp Asn Leu Pro Glu Glu Val Val Ala Asn Ser Tyr 
465                 470                 475                 480 


Arg Leu Pro Arg Glu Gln Ala Arg Gln Leu Lys Asn Asn Asn Pro Phe 
                485                 490                 495     


Lys Phe Phe Val Pro Pro Phe Asp His Gln Ser Met Arg Glu Val Ala 
            500                 505                 510         


<210>  221
<211>  1270
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  221

Lys Ser Ser Pro Tyr Gln Lys Lys Thr Glu Asn Pro Cys Ala Gln Arg 
1               5                   10                  15      


Cys Leu Gln Ser Cys Gln Gln Glu Pro Asp Asp Leu Lys Gln Lys Ala 
            20                  25                  30          


Cys Glu Ser Arg Cys Thr Lys Leu Glu Tyr Asp Pro Arg Cys Val Tyr 
        35                  40                  45              


Asp Pro Arg Gly His Thr Gly Thr Thr Asn Gln Arg Ser Pro Pro Gly 
    50                  55                  60                  


Glu Arg Thr Arg Gly Arg Gln Pro Gly Asp Tyr Asp Asp Asp Arg Arg 
65                  70                  75                  80  


Gln Pro Arg Arg Glu Glu Gly Gly Arg Trp Gly Pro Ala Gly Pro Arg 
                85                  90                  95      


Glu Arg Glu Arg Glu Glu Asp Trp Arg Gln Pro Arg Glu Asp Trp Arg 
            100                 105                 110         


Arg Pro Ser His Gln Gln Pro Arg Lys Ile Arg Pro Glu Gly Arg Glu 
        115                 120                 125             


Gly Glu Gln Glu Trp Gly Thr Pro Gly Ser His Val Arg Glu Glu Thr 
    130                 135                 140                 


Ser Arg Asn Asn Pro Phe Tyr Phe Pro Ser Arg Arg Phe Ser Thr Arg 
145                 150                 155                 160 


Tyr Gly Asn Gln Asn Gly Arg Ile Arg Val Leu Gln Arg Phe Asp Gln 
                165                 170                 175     


Arg Ser Arg Gln Phe Gln Asn Leu Gln Asn His Arg Ile Val Gln Ile 
            180                 185                 190         


Glu Ala Lys Pro Asn Thr Leu Val Leu Pro Lys His Ala Asp Ala Asp 
        195                 200                 205             


Asn Ile Leu Val Ile Gln Gln Gly Gln Ala Thr Val Thr Val Ala Asn 
    210                 215                 220                 


Gly Asn Asn Arg Lys Ser Phe Asn Leu Asp Glu Gly His Ala Leu Arg 
225                 230                 235                 240 


Ile Pro Ser Gly Phe Ile Ser Tyr Ile Leu Asn Arg His Asp Asn Gln 
                245                 250                 255     


Asn Leu Arg Val Ala Lys Ile Ser Met Pro Val Asn Thr Pro Gly Gln 
            260                 265                 270         


Phe Glu Asp Phe Phe Pro Ala Ser Ser Arg Asp Gln Ser Ser Tyr Leu 
        275                 280                 285             


Gln Gly Phe Ser Arg Asn Thr Leu Glu Ala Ala Phe Asn Ala Glu Phe 
    290                 295                 300                 


Asn Glu Ile Arg Arg Val Leu Leu Glu Glu Asn Ala Gly Gly Glu Gln 
305                 310                 315                 320 


Glu Glu Arg Gly Gln Arg Arg Trp Ser Thr Arg Ser Ser Glu Asn Asn 
                325                 330                 335     


Glu Gly Val Ile Val Lys Val Ser Lys Glu His Val Glu Glu Leu Thr 
            340                 345                 350         


Lys His Ala Lys Ser Val Ser Lys Lys Gly Ser Glu Glu Glu Gly Asp 
        355                 360                 365             


Ile Thr Asn Pro Ile Asn Leu Arg Glu Gly Glu Pro Asp Leu Ser Asn 
    370                 375                 380                 


Asn Phe Gly Lys Leu Phe Glu Val Lys Pro Asp Lys Lys Asn Pro Gln 
385                 390                 395                 400 


Leu Gln Asp Leu Asp Met Met Leu Thr Cys Val Glu Ile Lys Glu Gly 
                405                 410                 415     


Ala Leu Met Leu Pro His Phe Asn Ser Lys Ala Met Val Ile Val Val 
            420                 425                 430         


Val Asn Lys Gly Thr Gly Asn Leu Glu Leu Val Ala Val Arg Lys Glu 
        435                 440                 445             


Gln Gln Gln Arg Gly Arg Arg Glu Glu Glu Glu Asp Glu Asp Glu Glu 
    450                 455                 460                 


Glu Glu Gly Ser Asn Arg Glu Val Arg Arg Tyr Thr Ala Arg Leu Lys 
465                 470                 475                 480 


Glu Gly Asp Val Phe Ile Met Pro Ala Ala His Pro Val Ala Ile Asn 
                485                 490                 495     


Ala Ser Ser Glu Leu His Leu Leu Gly Phe Gly Ile Asn Ala Glu Asn 
            500                 505                 510         


Asn His Arg Ile Phe Leu Ala Gly Asp Lys Asp Asn Val Ile Asp Gln 
        515                 520                 525             


Ile Glu Lys Gln Ala Lys Asp Leu Ala Phe Pro Gly Ser Gly Glu Gln 
    530                 535                 540                 


Val Glu Lys Leu Ile Lys Asn Gln Lys Glu Ser His Phe Val Ser Ala 
545                 550                 555                 560 


Arg Pro Gln Ser Gln Ser Gln Ser Pro Ser Ser Pro Glu Lys Glu Ser 
                565                 570                 575     


Pro Glu Lys Glu Asp Gln Glu Glu Glu Asn Gln Gly Gly Lys Gly Pro 
            580                 585                 590         


Leu Leu Ser Ile Leu Lys Ala Phe Asn Gly Gly Gly Gly Leu Thr Ile 
        595                 600                 605             


Leu Val Ala Pro Ala Leu Phe Leu Leu Ala Ala His Ala Ser Ala Arg 
    610                 615                 620                 


Gln Gln Trp Glu Leu Gln Gly Asp Arg Arg Cys Gln Ser Gln Leu Glu 
625                 630                 635                 640 


Arg Ala Asn Leu Arg Pro Cys Glu Gln His Leu Met Gln Lys Ile Gln 
                645                 650                 655     


Arg Asp Glu Asp Ser Tyr Gly Arg Asp Pro Tyr Ser Pro Ser Gln Asp 
            660                 665                 670         


Pro Tyr Ser Pro Ser Gln Asp Pro Asp Arg Arg Asp Pro Tyr Ser Pro 
        675                 680                 685             


Ser Pro Tyr Asp Arg Arg Gly Ala Gly Ser Ser Gln His Gln Glu Arg 
    690                 695                 700                 


Cys Cys Asn Glu Leu Asn Glu Phe Glu Asn Asn Gln Arg Cys Met Cys 
705                 710                 715                 720 


Glu Ala Leu Gln Gln Ile Met Glu Asn Gln Ser Asp Arg Leu Gln Gly 
                725                 730                 735     


Arg Gln Gln Glu Gln Gln Phe Lys Arg Glu Leu Arg Asn Leu Pro Gln 
            740                 745                 750         


Gln Cys Gly Leu Arg Ala Pro Gln Arg Cys Asp Leu Glu Val Glu Ser 
        755                 760                 765             


Gly Gly Arg Asp Arg Tyr Gly Gly Gly Gly Val Thr Phe Arg Gln Gly 
    770                 775                 780                 


Gly Glu Glu Asn Glu Cys Gln Phe Gln Arg Leu Asn Ala Gln Arg Pro 
785                 790                 795                 800 


Asp Asn Arg Ile Glu Ser Glu Gly Gly Tyr Ile Glu Thr Trp Asn Pro 
                805                 810                 815     


Asn Asn Gln Glu Phe Gln Cys Ala Gly Val Ala Leu Ser Arg Thr Val 
            820                 825                 830         


Leu Arg Arg Asn Ala Leu Arg Arg Pro Phe Tyr Ser Asn Ala Pro Leu 
        835                 840                 845             


Glu Ile Tyr Val Gln Gln Gly Ser Gly Tyr Phe Gly Leu Ile Phe Pro 
    850                 855                 860                 


Gly Cys Pro Ser Thr Tyr Glu Glu Pro Ala Gln Glu Gly Arg Arg Tyr 
865                 870                 875                 880 


Gln Ser Gln Lys Pro Ser Arg Arg Phe Gln Val Gly Gln Asp Asp Pro 
                885                 890                 895     


Ser Gln Gln Gln Gln Asp Ser His Gln Lys Val His Arg Phe Asp Glu 
            900                 905                 910         


Gly Asp Leu Ile Ala Val Pro Thr Gly Val Ala Phe Trp Met Tyr Asn 
        915                 920                 925             


Asp Glu Asp Thr Asp Val Val Thr Val Thr Leu Ser Asp Thr Ser Ser 
    930                 935                 940                 


Ile His Asn Gln Leu Asp Gln Phe Pro Arg Arg Phe Tyr Leu Ala Gly 
945                 950                 955                 960 


Asn Gln Glu Gln Glu Phe Leu Arg Tyr Gln Gln Gln Gln Gly Ser Arg 
                965                 970                 975     


Pro His Tyr Arg Gln Ile Ser Pro Arg Val Arg Gly Asp Glu Gln Glu 
            980                 985                 990         


Asn Glu Gly Ser Asn Ile Phe Ser  Gly Phe Ala Gln Glu  Phe Leu Gln 
        995                 1000                 1005             


His Ala  Phe Gln Val Asp Arg  Gln Thr Val Glu Asn  Leu Arg Gly 
    1010                 1015                 1020             


Glu Asn  Glu Arg Glu Glu Gln  Gly Ala Ile Val Thr  Val Lys Gly 
    1025                 1030                 1035             


Gly Leu  Arg Ile Leu Ser Pro  Asp Glu Glu Asp Glu  Ser Ser Arg 
    1040                 1045                 1050             


Ser Pro  Pro Asn Arg Arg Glu  Glu Phe Asp Glu Asp  Arg Ser Arg 
    1055                 1060                 1065             


Pro Gln  Gln Arg Gly Lys Tyr  Asp Glu Asn Arg Arg  Gly Tyr Lys 
    1070                 1075                 1080             


Asn Gly  Ile Glu Glu Thr Ile  Cys Ser Ala Ser Val  Lys Lys Asn 
    1085                 1090                 1095             


Leu Gly  Arg Ser Ser Asn Pro  Asp Ile Tyr Asn Pro  Gln Ala Gly 
    1100                 1105                 1110             


Ser Leu  Arg Ser Val Asn Glu  Leu Asp Leu Pro Ile  Leu Gly Trp 
    1115                 1120                 1125             


Leu Gly  Leu Ser Ala Gln His  Gly Thr Ile Tyr Arg  Asn Ala Met 
    1130                 1135                 1140             


Phe Val  Pro His Tyr Thr Leu  Asn Ala His Thr Ile  Val Val Ala 
    1145                 1150                 1155             


Leu Asn  Gly Arg Ala His Val  Gln Val Val Asp Ser  Asn Gly Asn 
    1160                 1165                 1170             


Arg Val  Tyr Asp Glu Glu Leu  Gln Glu Gly His Val  Leu Val Val 
    1175                 1180                 1185             


Pro Gln  Asn Phe Ala Val Ala  Ala Lys Ala Gln Ser  Glu Asn Tyr 
    1190                 1195                 1200             


Glu Tyr  Leu Ala Phe Lys Thr  Asp Ser Arg Pro Ser  Ile Ala Asn 
    1205                 1210                 1215             


Gln Ala  Gly Glu Asn Ser Ile  Ile Asp Asn Leu Pro  Glu Glu Val 
    1220                 1225                 1230             


Val Ala  Asn Ser Tyr Arg Leu  Pro Arg Glu Gln Ala  Arg Gln Leu 
    1235                 1240                 1245             


Lys Asn  Asn Asn Pro Phe Lys  Phe Phe Val Pro Pro  Phe Asp His 
    1250                 1255                 1260             


Gln Ser  Met Arg Glu Val Ala  
    1265                 1270 


<210>  222
<211>  374
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  222

Met Asp Ser Pro Cys Leu Val Ala Leu Leu Val Phe Ser Phe Val Ile 
1               5                   10                  15      


Gly Ser Cys Phe Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ser Asn Trp Ala Gln Asn Arg Met Lys Leu Ala Asp Cys Ala Val Gly 
        35                  40                  45              


Phe Gly Ser Ser Thr Met Gly Gly Lys Gly Gly Asp Leu Tyr Thr Val 
    50                  55                  60                  


Thr Asn Ser Asp Asp Asp Pro Val Asn Pro Ala Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Asp Arg Pro Leu Trp Ile Ile Phe Ser Gly Asn 
                85                  90                  95      


Met Asn Ile Lys Leu Lys Met Pro Met Tyr Ile Ala Gly Tyr Lys Thr 
            100                 105                 110         


Phe Asp Gly Arg Gly Ala Gln Val Tyr Ile Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Val Phe Ile Lys Arg Val Ser Asn Val Ile Ile His Gly Leu Tyr Leu 
    130                 135                 140                 


Tyr Gly Cys Ser Thr Ser Val Leu Gly Asn Val Leu Ile Asn Glu Ser 
145                 150                 155                 160 


Phe Gly Val Glu Pro Val His Pro Gln Asp Gly Asp Ala Leu Thr Leu 
                165                 170                 175     


Arg Thr Ala Thr Asn Ile Trp Ile Asp His Asn Ser Phe Ser Asn Ser 
            180                 185                 190         


Ser Asp Gly Leu Val Asp Val Thr Leu Thr Ser Thr Gly Val Thr Ile 
        195                 200                 205             


Ser Asn Asn Leu Phe Phe Asn His His Lys Val Met Ser Leu Gly His 
    210                 215                 220                 


Asp Asp Ala Tyr Ser Asp Asp Lys Ser Met Lys Val Thr Val Ala Phe 
225                 230                 235                 240 


Asn Gln Phe Gly Pro Asn Cys Gly Gln Arg Met Pro Arg Ala Arg Tyr 
                245                 250                 255     


Gly Leu Val His Val Ala Asn Asn Asn Tyr Asp Pro Trp Thr Ile Tyr 
            260                 265                 270         


Ala Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser 
        275                 280                 285             


Phe Thr Ala Pro Asn Glu Ser Tyr Lys Lys Gln Val Thr Ile Arg Ile 
    290                 295                 300                 


Gly Cys Lys Thr Ser Ser Ser Cys Ser Asn Trp Val Trp Gln Ser Thr 
305                 310                 315                 320 


Gln Asp Val Phe Tyr Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Tyr 
                325                 330                 335     


Glu Gly Gly Asn Ile Tyr Thr Lys Lys Glu Ala Phe Asn Val Glu Asn 
            340                 345                 350         


Gly Asn Ala Thr Pro His Leu Thr Gln Asn Ala Gly Val Leu Thr Cys 
        355                 360                 365             


Ser Leu Ser Lys Arg Cys 
    370                 


<210>  223
<211>  514
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  223

Met Ala Met Lys Leu Ile Ala Pro Met Ala Phe Leu Ala Met Gln Leu 
1               5                   10                  15      


Ile Ile Met Ala Ala Val Glu Asp Gln Ser Ala Gln Ile Met Leu Asp 
            20                  25                  30          


Ser Val Val Glu Lys Tyr Leu Arg Ser Asn Arg Ser Leu Arg Lys Val 
        35                  40                  45              


Glu His Ser Arg His Asp Ala Ile Asn Ile Phe Asn Val Glu Lys Tyr 
    50                  55                  60                  


Gly Ala Val Gly Asp Gly Lys His Asp Cys Thr Glu Ala Phe Ser Thr 
65                  70                  75                  80  


Ala Trp Gln Ala Ala Cys Lys Asn Pro Ser Ala Met Leu Leu Val Pro 
                85                  90                  95      


Gly Ser Lys Lys Phe Val Val Asn Asn Leu Phe Phe Asn Gly Pro Cys 
            100                 105                 110         


Gln Pro His Phe Thr Phe Lys Val Asp Gly Ile Ile Ala Ala Tyr Gln 
        115                 120                 125             


Asn Pro Ala Ser Trp Lys Asn Asn Arg Ile Trp Leu Gln Phe Ala Lys 
    130                 135                 140                 


Leu Thr Gly Phe Thr Leu Met Gly Lys Gly Val Ile Asp Gly Gln Gly 
145                 150                 155                 160 


Lys Gln Trp Trp Ala Gly Gln Cys Lys Trp Val Asn Gly Arg Glu Ile 
                165                 170                 175     


Cys Asn Asp Arg Asp Arg Pro Thr Ala Ile Lys Phe Asp Phe Ser Thr 
            180                 185                 190         


Gly Leu Ile Ile Gln Gly Leu Lys Leu Met Asn Ser Pro Glu Phe His 
        195                 200                 205             


Leu Val Phe Gly Asn Cys Glu Gly Val Lys Ile Ile Gly Ile Ser Ile 
    210                 215                 220                 


Thr Ala Pro Arg Asp Ser Pro Asn Thr Asp Gly Ile Asp Ile Phe Ala 
225                 230                 235                 240 


Ser Lys Asn Phe His Leu Gln Lys Asn Thr Ile Gly Thr Gly Asp Asp 
                245                 250                 255     


Cys Val Ala Ile Gly Thr Gly Ser Ser Asn Ile Val Ile Glu Asp Leu 
            260                 265                 270         


Ile Cys Gly Pro Gly His Gly Ile Ser Ile Gly Ser Leu Gly Arg Glu 
        275                 280                 285             


Asn Ser Arg Ala Glu Val Ser Tyr Val His Val Asn Gly Ala Lys Phe 
    290                 295                 300                 


Ile Asp Thr Gln Asn Gly Leu Arg Ile Lys Thr Trp Gln Gly Gly Ser 
305                 310                 315                 320 


Gly Met Ala Ser His Ile Ile Tyr Glu Asn Val Glu Met Ile Asn Ser 
                325                 330                 335     


Glu Asn Pro Ile Leu Ile Asn Gln Phe Tyr Cys Thr Ser Ala Ser Ala 
            340                 345                 350         


Cys Gln Asn Gln Arg Ser Ala Val Gln Ile Gln Asp Val Thr Tyr Lys 
        355                 360                 365             


Asn Ile Arg Gly Thr Ser Ala Thr Ala Ala Ala Ile Gln Leu Lys Cys 
    370                 375                 380                 


Ser Asp Ser Met Pro Cys Lys Asp Ile Lys Leu Ser Asp Ile Ser Leu 
385                 390                 395                 400 


Lys Leu Thr Ser Gly Lys Ile Ala Ser Cys Leu Asn Asp Asn Ala Asn 
                405                 410                 415     


Gly Tyr Phe Ser Gly His Val Ile Pro Ala Cys Lys Asn Leu Ser Pro 
            420                 425                 430         


Ser Ala Lys Arg Lys Glu Ser Lys Ser His Lys His Pro Lys Thr Val 
        435                 440                 445             


Met Val Glu Asn Met Arg Ala Tyr Asp Lys Gly Asn Arg Thr Arg Ile 
    450                 455                 460                 


Leu Leu Gly Ser Arg Pro Pro Asn Cys Thr Asn Lys Cys His Gly Cys 
465                 470                 475                 480 


Ser Pro Cys Lys Ala Lys Leu Val Ile Val His Arg Ile Met Pro Gln 
                485                 490                 495     


Glu Tyr Tyr Pro Gln Arg Trp Ile Cys Ser Cys His Gly Lys Ile Tyr 
            500                 505                 510         


His Pro 
        


<210>  224
<211>  852
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  224

Glu Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp Ser Asn Trp Ala 
1               5                   10                  15      


Gln Asn Arg Met Lys Leu Ala Asp Cys Ala Val Gly Phe Gly Ser Ser 
            20                  25                  30          


Thr Met Gly Gly Lys Gly Gly Asp Leu Tyr Thr Val Thr Asn Ser Asp 
        35                  40                  45              


Asp Asp Pro Val Asn Pro Ala Pro Gly Thr Leu Arg Tyr Gly Ala Thr 
    50                  55                  60                  


Arg Asp Arg Pro Leu Trp Ile Ile Phe Ser Gly Asn Met Asn Ile Lys 
65                  70                  75                  80  


Leu Lys Met Pro Met Tyr Ile Ala Gly Tyr Lys Thr Phe Asp Gly Arg 
                85                  90                  95      


Gly Ala Gln Val Tyr Ile Gly Asn Gly Gly Pro Cys Val Phe Ile Lys 
            100                 105                 110         


Arg Val Ser Asn Val Ile Ile His Gly Leu His Leu Tyr Gly Cys Ser 
        115                 120                 125             


Thr Ser Val Leu Gly Asn Val Leu Ile Asn Glu Ser Phe Gly Val Glu 
    130                 135                 140                 


Pro Val His Pro Gln Asp Gly Asp Ala Leu Thr Leu Arg Thr Ala Thr 
145                 150                 155                 160 


Asn Ile Trp Ile Asp His Asn Ser Phe Ser Asn Ser Ser Asp Gly Leu 
                165                 170                 175     


Val Asp Val Thr Leu Ser Ser Thr Gly Val Thr Ile Ser Asn Asn Leu 
            180                 185                 190         


Phe Phe Asn His His Lys Val Met Leu Leu Gly His Asp Asp Ala Tyr 
        195                 200                 205             


Ser Asp Asp Lys Ser Met Lys Val Thr Val Ala Phe Asn Gln Phe Gly 
    210                 215                 220                 


Pro Asn Cys Gly Gln Arg Met Pro Arg Ala Arg Tyr Gly Leu Val His 
225                 230                 235                 240 


Val Ala Asn Asn Asn Tyr Asp Pro Trp Thr Ile Tyr Ala Ile Gly Gly 
                245                 250                 255     


Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser Phe Thr Ala Pro 
            260                 265                 270         


Asn Glu Ser Tyr Lys Lys Gln Val Thr Ile Arg Ile Gly Cys Lys Thr 
        275                 280                 285             


Ser Ser Ser Cys Ser Asn Trp Val Trp Gln Ser Thr Gln Asp Val Phe 
    290                 295                 300                 


Tyr Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Tyr Glu Gly Gly Asn 
305                 310                 315                 320 


Ile Tyr Thr Lys Lys Glu Ala Phe Asn Val Glu Asn Gly Asn Ala Thr 
                325                 330                 335     


Pro Gln Leu Thr Lys Asn Ala Gly Val Leu Thr Cys Ser Leu Ser Lys 
            340                 345                 350         


Arg Cys Gly Pro Gly Pro Gly Leu Glu Asp Gln Ser Ala Gln Ile Met 
        355                 360                 365             


Leu Asp Ser Val Val Glu Lys Tyr Leu Arg Ser Asn Arg Ser Leu Arg 
    370                 375                 380                 


Lys Val Glu His Ser Arg His Asp Ala Ile Asn Ile Phe Asn Val Glu 
385                 390                 395                 400 


Lys Tyr Gly Ala Val Gly Asp Gly Lys His Asp Cys Thr Glu Ala Phe 
                405                 410                 415     


Ser Thr Ala Trp Gln Ala Ala Cys Lys Asn Pro Ser Ala Met Leu Leu 
            420                 425                 430         


Val Pro Gly Ser Lys Lys Phe Val Val Asn Asn Leu Phe Phe Asn Gly 
        435                 440                 445             


Pro Cys Gln Pro His Phe Thr Phe Lys Val Asp Gly Ile Ile Ala Ala 
    450                 455                 460                 


Tyr Gln Asn Pro Ala Ser Trp Lys Asn Asn Arg Ile Trp Leu Gln Phe 
465                 470                 475                 480 


Ala Lys Leu Thr Gly Phe Thr Leu Met Gly Lys Gly Val Ile Asp Gly 
                485                 490                 495     


Gln Gly Lys Gln Trp Trp Ala Gly Gln Cys Lys Trp Val Asn Gly Arg 
            500                 505                 510         


Glu Ile Cys Asn Asp Arg Asp Arg Pro Thr Ala Ile Lys Phe Asp Phe 
        515                 520                 525             


Ser Thr Gly Leu Ile Ile Gln Gly Leu Lys Leu Met Asn Ser Pro Glu 
    530                 535                 540                 


Phe His Leu Val Phe Gly Asn Cys Glu Gly Val Lys Ile Ile Gly Ile 
545                 550                 555                 560 


Ser Ile Thr Ala Pro Arg Asp Ser Pro Asn Thr Asp Gly Ile Asp Ile 
                565                 570                 575     


Phe Ala Ser Lys Asn Phe His Leu Gln Lys Asn Thr Ile Gly Thr Gly 
            580                 585                 590         


Asp Asp Cys Val Ala Ile Gly Thr Gly Ser Ser Asn Ile Val Ile Glu 
        595                 600                 605             


Asp Leu Ile Cys Gly Pro Gly His Gly Ile Ser Ile Gly Ser Leu Gly 
    610                 615                 620                 


Arg Glu Asn Ser Arg Ala Glu Val Ser Tyr Val His Val Asn Gly Ala 
625                 630                 635                 640 


Lys Phe Ile Asp Thr Gln Asn Gly Leu Arg Ile Lys Thr Trp Gln Gly 
                645                 650                 655     


Gly Ser Gly Met Ala Ser His Ile Ile Tyr Glu Asn Val Glu Met Ile 
            660                 665                 670         


Asn Ser Glu Asn Pro Ile Leu Ile Asn Gln Phe Tyr Cys Thr Ser Ala 
        675                 680                 685             


Ser Ala Cys Gln Asn Gln Arg Ser Ala Val Gln Ile Gln Asp Val Thr 
    690                 695                 700                 


Tyr Lys Asn Ile Arg Gly Thr Ser Ala Thr Ala Ala Ala Ile Gln Leu 
705                 710                 715                 720 


Lys Cys Ser Asp Ser Met Pro Cys Lys Asp Ile Lys Leu Ser Asp Ile 
                725                 730                 735     


Ser Leu Lys Leu Thr Ser Gly Lys Ile Ala Ser Cys Leu Asn Asp Asn 
            740                 745                 750         


Ala Asn Gly Tyr Phe Ser Gly His Val Ile Pro Ala Cys Lys Asn Leu 
        755                 760                 765             


Ser Pro Ser Ala Lys Arg Lys Glu Ser Lys Ser His Lys His Pro Lys 
    770                 775                 780                 


Thr Val Met Val Glu Asn Met Arg Ala Tyr Asp Lys Gly Asn Arg Thr 
785                 790                 795                 800 


Arg Ile Leu Leu Gly Ser Arg Pro Pro Asn Cys Thr Asn Lys Cys His 
                805                 810                 815     


Gly Cys Ser Pro Cys Lys Ala Lys Leu Val Ile Val His Arg Ile Met 
            820                 825                 830         


Pro Gln Glu Tyr Tyr Pro Gln Arg Trp Ile Cys Ser Cys His Gly Lys 
        835                 840                 845             


Ile Tyr His Pro 
    850         


<210>  225
<211>  225
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  225

Met Ala Lys Val Ser Asp Leu Ala Leu Leu Leu Val Ala Gly Met Ala 
1               5                   10                  15      


Ile Ser Leu Tyr Ile Gln Glu Thr Gly Ala Val Lys Phe Asp Ile Lys 
            20                  25                  30          


Asn Gln Cys Gly Tyr Thr Val Trp Ala Ala Gly Leu Pro Gly Gly Gly 
        35                  40                  45              


Gln Gln Leu Thr Gln Gly Gln Thr Trp Thr Val Asn Leu Ala Ala Gly 
    50                  55                  60                  


Thr Gln Ser Ala Arg Phe Trp Gly Arg Thr Gly Cys Ser Phe Asp Ala 
65                  70                  75                  80  


Ser Gly Lys Gly Thr Cys Gln Thr Gly Asp Cys Gly Gly Gln Leu Ser 
                85                  90                  95      


Cys Thr Val Ser Gly Ala Val Pro Ala Thr Leu Ala Glu Tyr Thr Gln 
            100                 105                 110         


Ser Asp Gln Asp Tyr Tyr Asp Val Ser Leu Val Asp Gly Phe Asn Ile 
        115                 120                 125             


Pro Leu Ser Ile Asn Pro Thr Asn Ala Gln Cys Thr Ala Pro Ala Cys 
    130                 135                 140                 


Lys Ala Asp Val Asn Ala Val Cys Pro Ala Glu Leu Lys Val Asp Gly 
145                 150                 155                 160 


Gly Cys Lys Ser Ala Cys Ala Ala Phe Gln Thr Asp Gln Tyr Cys Cys 
                165                 170                 175     


Thr Gly Thr Tyr Ala Asn Ser Cys Pro Ala Thr Asn Tyr Ser Met Ile 
            180                 185                 190         


Phe Lys Asn Gln Cys Pro Gln Ala Tyr Ser Tyr Pro Lys Asp Asp Thr 
        195                 200                 205             


Ala Thr Phe Ala Cys Pro Ser Gly Thr Asp Tyr Ser Ile Val Phe Cys 
    210                 215                 220                 


Pro 
225 


<210>  226
<211>  281
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  226

Met Gly Ile Met Ala Thr Gln Asn Ser Lys Ser Asn Ile Phe Trp Ser 
1               5                   10                  15      


Ser Ser Ala Ser Val Val Leu Val Leu Leu Leu Leu Val Asp Val Gly 
            20                  25                  30          


Val Cys Gln Asn Cys Gly Cys Asn Gly Leu Cys Cys Ser Gln Tyr Gly 
        35                  40                  45              


Tyr Cys Gly Ser Gly Glu Ala Tyr Cys Gly Ala Gly Cys Lys Glu Gly 
    50                  55                  60                  


Pro Cys Ser Ser Ser Ser Pro Pro Ser Thr Gly Thr Gly Val Gly Ser 
65                  70                  75                  80  


Ile Val Ser Ser Asp Val Phe Asn Ser Ile Val Gly Gly Ala Ala Ser 
                85                  90                  95      


Gly Cys Ala Gly Asn Gly Phe Tyr Thr Tyr Asp Ser Phe Ile Ser Ala 
            100                 105                 110         


Ala Asn Ala Phe Asn Gly Phe Gly Thr Ser Gly Ser Ser Asp Val Asn 
        115                 120                 125             


Lys Arg Glu Ile Ala Ala Phe Phe Ala Asn Ala Ala His Glu Thr Gly 
    130                 135                 140                 


Gly Phe Cys Tyr Ile Glu Glu Gln Asn Pro Thr Ser Ile Tyr Cys Asp 
145                 150                 155                 160 


Ala Ser Asn Thr Gln Tyr Pro Cys Ala Ser Gly Lys Thr Tyr His Gly 
                165                 170                 175     


Arg Gly Pro Leu Gln Leu Ser Trp Asn Tyr Asn Tyr Gly Ala Ala Gly 
            180                 185                 190         


Ser Tyr Ile Gln Phe Asp Gly Leu Asn Asn Pro Glu Ile Val Gly Thr 
        195                 200                 205             


Asp Ser Thr Ile Ser Phe Lys Thr Ala Val Trp Phe Trp Met Val Asn 
    210                 215                 220                 


Ser Asn Cys His Thr Ala Ile Thr Ser Gly Gln Gly Phe Gly Ala Thr 
225                 230                 235                 240 


Ile Arg Ala Ile Asn Ser Met Glu Cys Asp Gly Gly Asn Ala Ala Thr 
                245                 250                 255     


Val Ala Ser Arg Val Asn Tyr Tyr Gln Lys Phe Cys Gln Gln Leu Asn 
            260                 265                 270         


Val Asp Thr Gly Ser Ala Leu Gln Cys 
        275                 280     


<210>  227
<211>  306
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  227

Met Gly Gly Ser Arg Val Leu Ile Ile Gly Gly Thr Gly Tyr Ile Gly 
1               5                   10                  15      


Arg His Val Thr Asn Ala Ser Leu Ala Gln Gly His Pro Thr Phe Leu 
            20                  25                  30          


Leu Val Arg Glu Ile Thr Pro Ser Asn Pro Glu Lys Ala Gln Leu Leu 
        35                  40                  45              


Glu Ser Phe Thr Ser Lys Gly Ala Thr Leu Val Gln Gly Ser Ile Asp 
    50                  55                  60                  


Asp His Ala Ser Leu Val Ala Ala Leu Lys Lys Val Asp Val Val Ile 
65                  70                  75                  80  


Ser Thr Leu Gly Ala Pro Gln Ile Ala Asp Gln Phe Asn Leu Ile Lys 
                85                  90                  95      


Ala Ile Lys Glu Val Gly Thr Ile Lys Arg Phe Phe Pro Ser Glu Phe 
            100                 105                 110         


Gly Asn Asp Val Asp Lys His His Ala Val Glu Pro Met Lys Ser Met 
        115                 120                 125             


Phe Asp Leu Lys Ile Lys Leu Arg Arg Thr Ile Glu Ala Glu Gly Ile 
    130                 135                 140                 


Pro His Thr Tyr Val Val Pro His Cys Phe Ala Gly Tyr Phe Leu Thr 
145                 150                 155                 160 


Asn Leu Ala Gln Leu Gly Leu Ala Ala Pro Pro Arg Asp Lys Ile Val 
                165                 170                 175     


Ile Tyr Gly Asp Gly Thr Thr Lys Ala Val Tyr Met Lys Glu Glu Asp 
            180                 185                 190         


Ile Gly Thr Phe Thr Ile Lys Ala Val Asp Asp Pro Arg Thr Leu Asn 
        195                 200                 205             


Lys Thr Leu Tyr Leu Lys Pro Pro Ala Asn Thr Ile Ser Thr Asn Asp 
    210                 215                 220                 


Leu Val Ala Leu Trp Glu Ala Lys Ile Gly Lys Thr Leu Glu Lys Val 
225                 230                 235                 240 


Tyr Leu Ser Glu Glu Gln Val Leu Lys Leu Leu Gln Asp Thr Pro Phe 
                245                 250                 255     


Pro Gly Thr Phe Met Val Ser Ile Phe His Thr Ile Tyr Val Lys Gly 
            260                 265                 270         


Asp Gln Thr Asn Phe Gln Ile Gly Pro Asp Gly Val Glu Ala Ser Ala 
        275                 280                 285             


Leu Tyr Pro Asp Val Lys Tyr Thr Thr Val Glu Glu Tyr Ile Ser Ala 
    290                 295                 300                 


Phe Val 
305     


<210>  228
<211>  165
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  228

Met Ala Met Arg Met Lys Ser Ser Ser Met Ser Ser Tyr Arg Phe Ser 
1               5                   10                  15      


Tyr Cys Gln Met Met Leu Val Leu Met Val Met Thr Leu Val Gln Ile 
            20                  25                  30          


Gly Ala Ala Gln Ser Asp Thr Asn Ser Cys Val Asn Ser Leu Val Pro 
        35                  40                  45              


Cys Ala Ser Tyr Leu Asn Ala Thr Thr Lys Pro Pro Asp Ser Cys Cys 
    50                  55                  60                  


Val Pro Leu Leu Asn Val Ile Gln Thr Gln Gln Gln Cys Leu Cys Asn 
65                  70                  75                  80  


Leu Leu Asn Ser Ser Ile Val Lys Gln Ser Ser Ile Asn Ile Thr Gln 
                85                  90                  95      


Ala Leu Asn Ile Pro Arg Leu Cys Gly Asp Thr Asn Val Ser Thr Asp 
            100                 105                 110         


Ala Cys Ser Thr Asn Ala Thr Ala Asn Ala Pro Ser Ala Ser Thr Thr 
        115                 120                 125             


Pro Ser Val Pro Ala Asp Thr Gly Asp Ser Ser Gly Ile Gly Ala Thr 
    130                 135                 140                 


Ser Leu Gln Ile Phe Leu Pro Leu Leu Ala Val Phe Phe Leu Gly Val 
145                 150                 155                 160 


Phe Lys Ser Phe Pro 
                165 


<210>  229
<211>  472
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  229

Met Ala Arg Arg Leu Cys Ser Phe Leu Leu Ser Phe Leu Ile Ile Val 
1               5                   10                  15      


Ser Val Trp Ala Glu Asn Ser Lys Phe Ala Arg Leu Asn Leu Ala Ser 
            20                  25                  30          


Phe Thr Trp Lys Asp Ala Glu Asp Asn Lys Asn Cys Ser Ala Gly Glu 
        35                  40                  45              


Leu Glu Thr Ser Ser Leu Ser Val Met His Ile Gln Gly Lys Cys Ser 
    50                  55                  60                  


Pro Phe Arg Leu Leu Asn Ser Ser Trp Trp Thr Ala Val Ser Glu Ser 
65                  70                  75                  80  


Ile Lys Gly Asp Thr Ala Arg Tyr Arg Ala Met Val Lys Gly Gly Trp 
                85                  90                  95      


Ser Ala Gly Lys Thr Met Val Asn Pro Gln Glu Asp Ala Asp Ile Pro 
            100                 105                 110         


Leu Ala Ser Gly Gln Ala Glu Ser Ser Ser Asn Tyr Ile Ile Lys Leu 
        115                 120                 125             


Gly Phe Gly Thr Pro Pro Gln Ser Phe Tyr Thr Val Leu Asp Thr Gly 
    130                 135                 140                 


Ser Asn Ile Ala Trp Ile Pro Cys Asn Pro Cys Ser Gly Cys Ser Ser 
145                 150                 155                 160 


Lys Gln Gln Pro Phe Glu Pro Ser Lys Ser Ser Thr Tyr Asn Tyr Leu 
                165                 170                 175     


Thr Cys Ala Ser Gln Gln Cys Gln Leu Leu Arg Val Cys Thr Lys Ser 
            180                 185                 190         


Asp Asn Ser Val Asn Cys Ser Leu Thr Gln Arg Tyr Gly Asp Gln Ser 
        195                 200                 205             


Glu Val Asp Glu Ile Leu Ser Ser Glu Thr Leu Ser Val Gly Ser Gln 
    210                 215                 220                 


Gln Val Glu Asn Phe Val Phe Gly Cys Ser Asn Ala Ala Arg Gly Leu 
225                 230                 235                 240 


Ile Gln Arg Thr Pro Ser Leu Val Gly Phe Gly Arg Asn Pro Leu Ser 
                245                 250                 255     


Phe Val Ser Gln Thr Ala Thr Leu Tyr Asp Ser Thr Phe Ser Tyr Cys 
            260                 265                 270         


Leu Pro Ser Leu Phe Ser Ser Ala Phe Thr Gly Ser Leu Leu Leu Gly 
        275                 280                 285             


Lys Glu Ala Leu Ser Ala Gln Gly Leu Lys Phe Thr Pro Leu Leu Ser 
    290                 295                 300                 


Asn Ser Arg Tyr Pro Ser Phe Tyr Tyr Val Gly Leu Asn Gly Ile Ser 
305                 310                 315                 320 


Val Gly Glu Glu Leu Val Ser Ile Pro Ala Gly Thr Leu Ser Leu Asp 
                325                 330                 335     


Glu Ser Thr Gly Arg Gly Thr Ile Ile Asp Ser Gly Thr Val Ile Thr 
            340                 345                 350         


Arg Leu Val Glu Pro Ala Tyr Asn Ala Met Arg Asp Ser Phe Arg Ser 
        355                 360                 365             


Gln Leu Ser Asn Leu Thr Met Ala Ser Pro Thr Asp Leu Phe Asp Thr 
    370                 375                 380                 


Cys Thr Asn Arg Pro Ser Gly Asp Val Glu Phe Pro Leu Ile Thr Leu 
385                 390                 395                 400 


His Phe Asp Asp Asn Leu Asp Leu Thr Leu Pro Leu Asp Asn Ile Leu 
                405                 410                 415     


Tyr Pro Gly Asn Asp Asp Gly Ser Val Leu Cys Leu Ala Phe Gly Leu 
            420                 425                 430         


Pro Pro Gly Gly Gly Asp Asp Val Leu Ser Thr Phe Gly Asn Tyr Gln 
        435                 440                 445             


Gln Gln Lys Leu Arg Ile Val His Asp Val Ala Glu Ser Arg Leu Gly 
    450                 455                 460                 


Ile Ala Ser Gly Asn Cys Asp Gly 
465                 470         


<210>  230
<211>  348
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  230

Met Glu Leu Leu Lys Gln His Arg Tyr Met Phe Leu Leu Ile Ser Cys 
1               5                   10                  15      


Ile Val Ile Leu Leu Asn Ser Met His Ala Asp Cys Glu Gln Ile Gly 
            20                  25                  30          


Val Asn Tyr Gly Met Asp Gly Asn Asn Leu Pro Ser Ala Gly Asp Val 
        35                  40                  45              


Val Ser Leu Met Lys Lys Asn Asn Ile Gly Lys Met Arg Ile Phe Gly 
    50                  55                  60                  


Pro Asn Ala Asp Val Leu Arg Ala Phe Ala Asn Ser Arg Ile Glu Val 
65                  70                  75                  80  


Ile Val Gly Val Glu Asn Lys Gly Leu Glu Ala Val Ala Ser Ser Gln 
                85                  90                  95      


Asp Ser Ala Asn Gly Trp Val Asn Asp Asn Ile Lys Pro Phe Tyr Pro 
            100                 105                 110         


Ser Thr Asn Ile Lys Tyr Ile Ala Val Gly Asn Glu Val Leu Glu Met 
        115                 120                 125             


Pro Asp Asn Ala Gln Tyr Val Ser Phe Leu Val Pro Ala Ile Lys Asn 
    130                 135                 140                 


Ile Gln Thr Ala Leu Glu Asn Ala Asn Leu Gln Asn Asn Ile Lys Val 
145                 150                 155                 160 


Ser Thr Ala His Ala Met Thr Val Ile Gly Thr Ser Ser Pro Pro Ser 
                165                 170                 175     


Lys Gly Thr Phe Lys Asp Ala Val Lys Asp Ser Met Ser Ser Ile Leu 
            180                 185                 190         


Gln Phe Leu Gln Asp His Gly Ser Pro Phe Met Ala Asn Val Tyr Pro 
        195                 200                 205             


Tyr Phe Ser Tyr Asp Gly Asp Arg Ser Ile Lys Leu Asp Tyr Ala Leu 
    210                 215                 220                 


Phe Asn Pro Thr Pro Pro Val Val Asp Glu Gly Leu Ser Tyr Thr Asn 
225                 230                 235                 240 


Leu Phe Asp Ala Met Val Asp Ala Val Leu Ser Ala Met Glu Ser Leu 
                245                 250                 255     


Gly His Pro Asn Ile Pro Ile Val Ile Thr Glu Ser Gly Trp Pro Ser 
            260                 265                 270         


Ala Gly Lys Ser Val Ala Thr Ile Glu Asn Ala Gln Thr Tyr Asn Asn 
        275                 280                 285             


Asn Leu Ile Lys His Val Leu Ser Asn Ala Gly Thr Pro Lys Arg Pro 
    290                 295                 300                 


Gly Ser Ser Ile Glu Thr Tyr Ile Phe Ala Leu Phe Asn Glu Asn Leu 
305                 310                 315                 320 


Lys Gly Pro Ala Glu Val Glu Lys His Phe Gly Leu Phe Asn Pro Asp 
                325                 330                 335     


Glu Gln Pro Val Tyr Pro Val Lys Phe Ser Leu Asn 
            340                 345             


<210>  231
<211>  375
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  231

Met Ala Ser Cys Thr Leu Leu Ala Val Leu Val Phe Leu Cys Ala Ile 
1               5                   10                  15      


Val Ser Cys Phe Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ala Asn Trp Asp Gln Asn Arg Met Lys Leu Ala Asp Cys Ala Val Gly 
        35                  40                  45              


Phe Gly Ser Ser Ala Met Gly Gly Lys Gly Gly Ala Phe Tyr Thr Val 
    50                  55                  60                  


Thr Ser Ser Asp Asp Asp Pro Val Asn Pro Ala Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Glu Arg Ser Leu Trp Ile Ile Phe Ser Lys Asn 
                85                  90                  95      


Leu Asn Ile Lys Leu Asn Met Pro Leu Tyr Ile Ala Gly Asn Lys Thr 
            100                 105                 110         


Ile Asp Gly Arg Gly Ala Glu Val His Ile Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Leu Phe Met Arg Thr Val Ser His Val Ile Leu His Gly Leu Asn Ile 
    130                 135                 140                 


His Gly Cys Asn Thr Ser Val Ser Gly Asn Val Leu Ile Ser Glu Ala 
145                 150                 155                 160 


Ser Gly Val Val Pro Val His Ala Gln Asp Gly Asp Ala Ile Thr Met 
                165                 170                 175     


Arg Asn Val Thr Asp Val Trp Ile Asp His Asn Ser Leu Ser Asp Ser 
            180                 185                 190         


Ser Asp Gly Leu Val Asp Val Thr Leu Ala Ser Thr Gly Val Thr Ile 
        195                 200                 205             


Ser Asn Asn His Phe Phe Asn His His Lys Val Met Leu Leu Gly His 
    210                 215                 220                 


Ser Asp Ile Tyr Ser Asp Asp Lys Ser Met Lys Val Thr Val Ala Phe 
225                 230                 235                 240 


Asn Gln Phe Gly Pro Asn Ala Gly Gln Arg Met Pro Arg Ala Arg Tyr 
                245                 250                 255     


Gly Leu Ile His Val Ala Asn Asn Asn Tyr Asp Pro Trp Ser Ile Tyr 
            260                 265                 270         


Ala Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser 
        275                 280                 285             


Phe Thr Ala Pro Asn Asp Ser Asp Lys Lys Glu Val Thr Arg Arg Val 
    290                 295                 300                 


Gly Cys Glu Ser Pro Ser Thr Cys Ala Asn Trp Val Trp Arg Ser Thr 
305                 310                 315                 320 


Gln Asp Ser Phe Asn Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Asn 
                325                 330                 335     


Glu Gly Thr Asn Ile Tyr Asn Asn Asn Glu Ala Phe Lys Val Glu Asn 
            340                 345                 350         


Gly Ser Ala Ala Pro Gln Leu Thr Lys Asn Ala Gly Val Leu Thr Cys 
        355                 360                 365             


Ile Leu Ser Lys Pro Cys Ser 
    370                 375 


<210>  232
<211>  367
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  232

Met Ala Ser Pro Cys Leu Ile Ala Val Leu Val Phe Leu Cys Ala Ile 
1               5                   10                  15      


Val Ser Cys Tyr Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ser Asn Trp Asp Gln Asn Arg Met Lys Leu Ala Asp Cys Ala Val Gly 
        35                  40                  45              


Phe Gly Ser Ser Thr Met Gly Gly Lys Gly Gly Asp Phe Tyr Thr Val 
    50                  55                  60                  


Thr Ser Thr Asp Asp Asn Pro Val Asn Pro Thr Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Glu Lys Ala Leu Trp Ile Ile Phe Ser Gln Asn 
                85                  90                  95      


Met Asn Ile Lys Leu Lys Met Pro Leu Tyr Val Ala Gly His Lys Thr 
            100                 105                 110         


Ile Asp Gly Arg Gly Ala Asp Val His Leu Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Leu Phe Met Arg Lys Val Ser His Val Ile Leu His Ser Leu His Ile 
    130                 135                 140                 


His Gly Cys Asn Thr Ser Val Leu Gly Asp Val Leu Val Ser Glu Ser 
145                 150                 155                 160 


Ile Gly Val Glu Pro Val His Ala Gln Asp Gly Asp Ala Ile Thr Met 
                165                 170                 175     


Arg Asn Val Thr Asn Ala Trp Ile Asp His Asn Ser Leu Ser Asp Cys 
            180                 185                 190         


Ser Asp Gly Leu Ile Asp Val Thr Leu Gly Ser Thr Gly Ile Thr Ile 
        195                 200                 205             


Ser Asn Asn His Phe Phe Asn His His Lys Val Met Leu Leu Gly His 
    210                 215                 220                 


Asp Asp Thr Tyr Asp Asp Asp Lys Ser Met Lys Val Thr Val Ala Phe 
225                 230                 235                 240 


Asn Gln Phe Gly Pro Asn Ala Gly Gln Arg Met Pro Arg Ala Arg Tyr 
                245                 250                 255     


Gly Leu Val His Val Ala Asn Asn Asn Tyr Asp Pro Trp Asn Ile Tyr 
            260                 265                 270         


Ala Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser 
        275                 280                 285             


Phe Thr Ala Pro Ser Glu Ser Tyr Lys Lys Glu Val Thr Lys Arg Ile 
    290                 295                 300                 


Gly Cys Glu Ser Pro Ser Ala Cys Ala Asn Trp Val Trp Arg Ser Thr 
305                 310                 315                 320 


Arg Asp Ala Phe Ile Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Thr 
                325                 330                 335     


Glu Glu Thr Asn Ile Tyr Asn Ser Asn Glu Ala Phe Lys Val Glu Asn 
            340                 345                 350         


Gly Asn Ala Ala Pro Gln Leu Thr Lys Asn Ala Gly Val Val Thr 
        355                 360                 365         


<210>  233
<211>  367
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  233

Met Ala Ser Pro Cys Leu Ile Ala Phe Leu Val Phe Leu Cys Ala Ile 
1               5                   10                  15      


Val Ser Cys Cys Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ser Asn Trp Gly Gln Asn Arg Met Lys Leu Ala Asp Cys Ala Val Gly 
        35                  40                  45              


Phe Gly Ser Ser Thr Met Gly Gly Lys Gly Gly Asp Phe Tyr Thr Val 
    50                  55                  60                  


Thr Ser Ala Asp Asp Asn Pro Val Asn Pro Thr Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Glu Lys Thr Leu Trp Ile Ile Phe Ser Gln Asn 
                85                  90                  95      


Met Asn Ile Lys Leu Lys Met Pro Leu Tyr Val Ala Gly His Lys Thr 
            100                 105                 110         


Ile Asp Gly Arg Gly Ala Asp Val His Leu Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Leu Phe Met Arg Lys Val Ser His Val Ile Leu His Gly Leu His Ile 
    130                 135                 140                 


His Gly Cys Asn Thr Ser Val Leu Gly Asp Val Leu Val Ser Glu Ser 
145                 150                 155                 160 


Ile Gly Val Val Pro Val His Ala Gln Asp Gly Asp Ala Ile Thr Met 
                165                 170                 175     


Arg Asn Val Thr Asn Ala Trp Ile Asp His Asn Ser Leu Ser Asp Cys 
            180                 185                 190         


Ser Asp Gly Leu Ile Asp Val Thr Leu Gly Ser Thr Gly Ile Thr Ile 
        195                 200                 205             


Phe Asn Asn His Phe Phe Asn His His Lys Val Met Leu Leu Gly His 
    210                 215                 220                 


Asp Asp Thr Tyr Asp Asp Asp Lys Ser Met Lys Val Thr Val Ala Phe 
225                 230                 235                 240 


Asn Gln Phe Gly Pro Asn Ala Gly Gln Arg Met Pro Arg Ala Arg Tyr 
                245                 250                 255     


Gly Leu Val His Val Ala Asn Asn Asn Tyr Asp Pro Trp Asn Ile Tyr 
            260                 265                 270         


Ala Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser 
        275                 280                 285             


Phe Thr Ala Pro Asn Glu Asn Tyr Lys Tyr Glu Val Thr Lys Arg Ile 
    290                 295                 300                 


Gly Cys Glu Ser Thr Ser Ala Cys Ala Asn Trp Val Trp Arg Ser Thr 
305                 310                 315                 320 


Arg Asp Ala Phe Ser Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Ile 
                325                 330                 335     


Glu Glu Thr Asn Ile Tyr Asn Ser Asn Glu Ala Phe Lys Val Glu Asn 
            340                 345                 350         


Gly Asn Ala Ala Pro Gln Leu Thr Lys Asn Ala Gly Val Val Ala 
        355                 360                 365         


<210>  234
<211>  367
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  234

Met Ala Ser Pro Cys Leu Val Ala Val Leu Val Phe Leu Cys Ala Ile 
1               5                   10                  15      


Val Ser Cys Tyr Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ser Asn Trp Asp Gln Asn Arg Met Lys Leu Ala Asp Cys Val Val Gly 
        35                  40                  45              


Phe Gly Ser Leu Thr Met Gly Gly Lys Gly Gly Glu Ile Tyr Thr Val 
    50                  55                  60                  


Thr Ser Ser Asp Asp Asn Pro Val Asn Pro Thr Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Glu Lys Ala Leu Trp Ile Ile Phe Ser Gln Asn 
                85                  90                  95      


Met Asn Ile Lys Leu Gln Met Pro Leu Tyr Val Ala Gly Tyr Lys Thr 
            100                 105                 110         


Ile Asp Gly Arg Gly Ala Asp Val His Leu Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Leu Phe Met Arg Thr Ala Ser His Val Ile Leu His Gly Leu His Ile 
    130                 135                 140                 


His Gly Cys Asn Thr Ser Val Leu Gly Asp Val Leu Val Ser Glu Ser 
145                 150                 155                 160 


Ile Gly Val Glu Pro Val His Ala Gln Asp Gly Asp Ala Ile Thr Met 
                165                 170                 175     


Arg Asn Val Thr Asn Ala Trp Ile Asp His Asn Ser Leu Ser Asp Cys 
            180                 185                 190         


Ser Asp Gly Leu Ile Asp Val Thr Leu Gly Ser Thr Gly Ile Thr Ile 
        195                 200                 205             


Ser Asn Asn His Phe Phe Asn His His Lys Val Met Leu Leu Gly His 
    210                 215                 220                 


Asp Asp Thr Tyr Asp Asp Asp Ile Ser Met Lys Val Thr Val Ala Phe 
225                 230                 235                 240 


Asn Gln Phe Gly Pro Asn Ala Gly Gln Arg Met Pro Arg Ala Arg Tyr 
                245                 250                 255     


Gly Leu Val His Val Ala Asn Asn Asn Tyr Asp Gln Trp Asn Ile Tyr 
            260                 265                 270         


Ala Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser 
        275                 280                 285             


Pro Thr Ala Pro Ser Glu Ser Tyr Lys Lys Glu Val Thr Lys Arg Ile 
    290                 295                 300                 


Gly Cys Glu Ser Thr Ser Ala Cys Ala Asn Trp Val Trp Arg Phe Thr 
305                 310                 315                 320 


Arg Asp Ala Phe Thr Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Ala 
                325                 330                 335     


Glu Glu Thr Asn Ile Tyr Asn Ser Asn Glu Ala Phe Lys Val Glu Asn 
            340                 345                 350         


Gly Asn Ala Ala Pro Gln Leu Thr Gln Asn Ala Gly Val Val Thr 
        355                 360                 365         


<210>  235
<211>  366
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  235

Met Ala Ser Pro Cys Leu Arg Ala Val Leu Val Phe Leu Cys Ala Ile 
1               5                   10                  15      


Val Ser Cys Tyr Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ser Asn Trp Gly Gln Asn Arg Met Lys Leu Ala Asp Cys Val Val Gly 
        35                  40                  45              


Phe Gly Ser Ser Thr Met Gly Gly Lys Gly Gly Glu Phe Tyr Thr Val 
    50                  55                  60                  


Thr Ser Ala Glu Asp Asn Pro Val Asn Pro Thr Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Glu Lys Ala Leu Trp Ile Ile Phe Ser Gln Asn 
                85                  90                  95      


Met Asn Ile Lys Leu Lys Met Pro Leu Tyr Val Ala Gly His Lys Thr 
            100                 105                 110         


Ile Asp Gly Arg Gly Ala Asp Val His Leu Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Leu Phe Met Arg Lys Val Ser His Val Ile Leu His Gly Leu His Ile 
    130                 135                 140                 


Gly Cys Asn Thr Ser Val Leu Gly Asp Val Leu Val Ser Glu Ser Ile 
145                 150                 155                 160 


Gly Val Glu Pro Val His Ala Gln Asp Gly Asp Ala Ile Thr Met Arg 
                165                 170                 175     


Asn Val Thr Asn Ala Trp Ile Asp His Asn Ser Leu Ser Asp Cys Ser 
            180                 185                 190         


Asp Gly Leu Ile Asp Val Thr Leu Gly Ser Thr Gly Ile Thr Ile Ser 
        195                 200                 205             


Asn Asn His Phe Phe Asn His His Lys Val Met Leu Leu Gly His Asp 
    210                 215                 220                 


Asp Thr Tyr Asp Asn Asp Lys Ser Met Lys Val Thr Val Ala Phe Asn 
225                 230                 235                 240 


Gln Phe Gly Pro Asn Ala Gly Gln Arg Met Pro Arg Ala Arg Tyr Gly 
                245                 250                 255     


Leu Val His Val Ala Asn Asn Asn Tyr Asp Pro Trp Asn Ile Tyr Ala 
            260                 265                 270         


Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser Phe 
        275                 280                 285             


Thr Ala Pro Ser Glu Ser Tyr Lys Lys Glu Val Thr Lys Arg Ile Gly 
    290                 295                 300                 


Cys Glu Ser Thr Ser Ala Cys Ala Asn Trp Val Trp Arg Ser Thr Arg 
305                 310                 315                 320 


Asp Ala Phe Thr Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Ile Glu 
                325                 330                 335     


Glu Thr Asn Ile Tyr Asn Ser Asn Glu Ala Phe Lys Val Glu Asn Gly 
            340                 345                 350         


Asn Ala Ala Pro Gln Leu Thr Lys Asn Ala Gly Val Val Thr 
        355                 360                 365     


<210>  236
<211>  367
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  236

Met Asp Ser Pro Cys Leu Ile Ala Val Leu Val Phe Leu Cys Ala Ile 
1               5                   10                  15      


Val Ser Cys Tyr Ser Asp Asn Pro Ile Asp Ser Cys Trp Arg Gly Asp 
            20                  25                  30          


Ser Asn Trp Asp Gln Asn Arg Met Lys Leu Ala Asp Cys Ala Val Gly 
        35                  40                  45              


Phe Gly Ser Ser Thr Met Gly Gly Lys Gly Gly Asp Ile Tyr Thr Val 
    50                  55                  60                  


Thr Ser Ala Glu Asp Asn Pro Val Asn Pro Thr Pro Gly Thr Leu Arg 
65                  70                  75                  80  


Tyr Gly Ala Thr Arg Glu Lys Ala Leu Trp Ile Ile Phe Ser Gln Asn 
                85                  90                  95      


Met Asn Ile Lys Leu Lys Met Pro Leu Tyr Val Ala Gly His Lys Thr 
            100                 105                 110         


Ile Asp Gly Arg Gly Ala Asp Val His Leu Gly Asn Gly Gly Pro Cys 
        115                 120                 125             


Leu Phe Met Arg Lys Val Ser His Val Ile Leu His Gly Leu His Ile 
    130                 135                 140                 


His Gly Cys Asn Thr Ser Val Leu Gly Asn Val Leu Val Ser Glu Ser 
145                 150                 155                 160 


Ile Gly Val Glu Pro Val His Ala Gln Asp Gly Asp Ala Ile Thr Met 
                165                 170                 175     


Arg Asn Val Thr Asn Ala Trp Ile Asp His Asn Ser Leu Ser Asp Cys 
            180                 185                 190         


Ser Asp Gly Leu Ile Asp Val Thr Leu Ser Ser Thr Gly Ile Thr Ile 
        195                 200                 205             


Ser Asn Asn His Phe Phe Asn His His Lys Val Met Leu Leu Gly His 
    210                 215                 220                 


Asp Asp Thr Tyr Asp Asp Asp Lys Ser Met Lys Val Thr Val Ala Phe 
225                 230                 235                 240 


Asn Gln Phe Gly Pro Asn Ala Gly Gln Arg Met Pro Arg Ala Arg Tyr 
                245                 250                 255     


Gly Leu Val His Val Ala Asn Asn Asn Tyr Asp Gln Trp Asn Ile Tyr 
            260                 265                 270         


Ala Ile Gly Gly Ser Ser Asn Pro Thr Ile Leu Ser Glu Gly Asn Ser 
        275                 280                 285             


Phe Ala Ala Pro Asn Glu Asn Tyr Lys Lys Glu Val Thr Lys Arg Ile 
    290                 295                 300                 


Gly Cys Val Ser Thr Ser Ala Cys Ala Asn Trp Val Trp Arg Ser Thr 
305                 310                 315                 320 


Arg Asp Ala Phe Ser Asn Gly Ala Tyr Phe Val Ser Ser Gly Lys Thr 
                325                 330                 335     


Glu Glu Thr Asn Ile Tyr Thr Ser Asn Glu Ala Phe Lys Val Glu Asn 
            340                 345                 350         


Gly Asn Leu Ala Pro Gln Leu Thr Lys Asn Ala Gly Val Val Ala 
        355                 360                 365         


<210>  237
<211>  514
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  237

Met Gly Met Lys Phe Met Ala Ala Val Ala Phe Leu Ala Leu Gln Leu 
1               5                   10                  15      


Ile Val Met Ala Ala Ala Glu Asp Gln Ser Ala Gln Ile Met Leu Asp 
            20                  25                  30          


Ser Asp Ile Glu Glu Tyr Leu Arg Ser Asn Arg Ser Leu Lys Lys Leu 
        35                  40                  45              


Val His Ser Arg His Asp Ala Ala Thr Val Phe Asn Val Glu Gln Tyr 
    50                  55                  60                  


Gly Ala Val Gly Asp Gly Lys His Asp Ser Thr Glu Ala Phe Ala Thr 
65                  70                  75                  80  


Thr Trp Asn Ala Ala Cys Lys Lys Ala Ser Ala Val Leu Leu Val Pro 
                85                  90                  95      


Ala Asn Lys Lys Phe Phe Val Asn Asn Leu Val Phe Arg Gly Pro Cys 
            100                 105                 110         


Gln Pro His Leu Ser Phe Lys Val Asp Gly Thr Ile Val Ala Gln Pro 
        115                 120                 125             


Asp Pro Ala Arg Trp Lys Asn Ser Lys Ile Trp Leu Gln Phe Ala Gln 
    130                 135                 140                 


Leu Thr Asp Phe Asn Leu Met Gly Thr Phe Val Ile Asp Gly Gln Gly 
145                 150                 155                 160 


Gln Gln Trp Trp Ala Gly Gln Cys Lys Val Val Asn Gly Arg Thr Val 
                165                 170                 175     


Cys Asn Asp Arg Asn Arg Pro Thr Ala Ile Lys Ile Asp Tyr Ser Lys 
            180                 185                 190         


Ser Val Thr Val Lys Glu Leu Thr Leu Met Asn Ser Pro Glu Phe His 
        195                 200                 205             


Leu Val Phe Gly Glu Cys Glu Gly Val Lys Ile Gln Gly Leu Lys Ile 
    210                 215                 220                 


Lys Ala Pro Arg Asp Ser Pro Asn Thr Asp Gly Ile Asp Ile Phe Ala 
225                 230                 235                 240 


Ser Lys Arg Phe His Ile Glu Lys Cys Val Ile Gly Thr Gly Asp Asp 
                245                 250                 255     


Cys Ile Ala Ile Gly Thr Gly Ser Ser Asn Ile Thr Ile Lys Asp Leu 
            260                 265                 270         


Ile Cys Gly Pro Gly His Gly Ile Ser Ile Gly Ser Leu Gly Arg Asp 
        275                 280                 285             


Asn Ser Arg Ala Glu Val Ser His Val His Val Asn Arg Ala Lys Phe 
    290                 295                 300                 


Ile Asp Thr Gln Asn Gly Leu Arg Ile Lys Thr Trp Gln Gly Gly Ser 
305                 310                 315                 320 


Gly Leu Ala Ser Tyr Ile Thr Tyr Glu Asn Val Glu Met Ile Asn Ser 
                325                 330                 335     


Glu Asn Pro Ile Leu Ile Asn Gln Phe Tyr Cys Thr Ser Ala Ser Ala 
            340                 345                 350         


Cys Gln Asn Gln Arg Ser Ala Val Gln Ile Gln Gly Val Thr Tyr Lys 
        355                 360                 365             


Asn Ile His Gly Thr Ser Ala Thr Ala Ala Ala Ile Gln Leu Met Cys 
    370                 375                 380                 


Ser Asp Ser Val Pro Cys Thr Gly Ile Gln Leu Ser Asn Val Ser Leu 
385                 390                 395                 400 


Lys Leu Thr Ser Gly Lys Pro Ala Ser Cys Val Asp Lys Asn Ala Arg 
                405                 410                 415     


Gly Phe Tyr Ser Gly Arg Leu Ile Pro Thr Cys Lys Asn Leu Arg Pro 
            420                 425                 430         


Gly Pro Ser Pro Lys Glu Phe Glu Leu Gln Gln Gln Pro Thr Thr Val 
        435                 440                 445             


Met Asp Glu Asn Lys Gly Ala Cys Ala Lys Gly Asp Ser Thr Cys Ile 
    450                 455                 460                 


Ser Leu Ser Ser Ser Pro Pro Asn Cys Lys Asn Lys Cys Lys Gly Cys 
465                 470                 475                 480 


Gln Pro Cys Lys Pro Lys Leu Ile Ile Val His Pro Asn Lys Pro Gln 
                485                 490                 495     


Asp Tyr Tyr Pro Gln Lys Trp Val Cys Ser Cys His Asn Lys Ile Tyr 
            500                 505                 510         


Asn Pro 
        


<210>  238
<211>  507
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  238

Met Ser Met Lys Phe Met Ala Ala Leu Ala Phe Leu Ala Leu Gln Leu 
1               5                   10                  15      


Ile Val Met Ala Ala Gly Glu Asp Gln Ser Ala Gln Ile Met Leu Asp 
            20                  25                  30          


Ser Asp Thr Lys Gln Tyr His Arg Ser Ser Arg Asn Leu Arg Lys Ala 
        35                  40                  45              


Val His His Ala Arg His Asp Val Ala Ile Val Phe Asn Val Glu His 
    50                  55                  60                  


Tyr Gly Ala Val Gly Asp Gly Lys His Asp Ser Thr Asp Ala Phe Glu 
65                  70                  75                  80  


Lys Thr Trp Asn Ala Ala Cys Asn Lys Leu Ser Ala Val Phe Leu Val 
                85                  90                  95      


Pro Ala Asn Lys Lys Phe Val Val Asn Asn Leu Val Phe Tyr Gly Pro 
            100                 105                 110         


Cys Gln Pro His Phe Ser Phe Lys Val Asp Gly Thr Ile Ala Ala Tyr 
        115                 120                 125             


Pro Asp Pro Ala Lys Trp Leu Asn Ser Lys Ile Trp Met His Phe Ala 
    130                 135                 140                 


Arg Leu Thr Asp Phe Asn Leu Met Gly Thr Gly Val Ile Asp Gly Gln 
145                 150                 155                 160 


Gly Asn Arg Trp Trp Ser Asp Gln Cys Lys Thr Ile Asn Gly Arg Thr 
                165                 170                 175     


Val Cys Asn Asp Lys Gly Arg Pro Thr Ala Ile Lys Ile Asp Phe Ser 
            180                 185                 190         


Lys Ser Val Thr Val Lys Glu Leu Thr Leu Thr Asn Ser Pro Glu Phe 
        195                 200                 205             


His Leu Val Phe Gly Glu Cys Asp Gly Val Lys Ile Gln Gly Ile Lys 
    210                 215                 220                 


Ile Lys Ala Pro Arg Asp Ser Pro Asn Thr Asp Gly Ile Asp Ile Phe 
225                 230                 235                 240 


Ala Ser Lys Arg Phe Glu Ile Glu Lys Cys Thr Ile Gly Thr Gly Asp 
                245                 250                 255     


Asp Cys Val Ala Val Gly Thr Gly Ser Ser Asn Ile Thr Ile Lys Asp 
            260                 265                 270         


Leu Thr Cys Gly Pro Gly His Gly Met Ser Ile Gly Ser Leu Gly Lys 
        275                 280                 285             


Gly Asn Ser Arg Ser Glu Val Ser Phe Val His Leu Asp Gly Ala Lys 
    290                 295                 300                 


Phe Ile Asp Thr Gln Asn Gly Leu Arg Ile Lys Thr Trp Gln Gly Gly 
305                 310                 315                 320 


Ser Gly Leu Ala Ser His Ile Thr Tyr Glu Asn Val Glu Met Ile Asn 
                325                 330                 335     


Ala Glu Asn Pro Ile Leu Ile Asn Gln Phe Tyr Cys Thr Ser Ala Ala 
            340                 345                 350         


Ala Cys Lys Asn Gln Arg Ser Ala Val Lys Ile Gln Asp Val Thr Phe 
        355                 360                 365             


Lys Asn Ile His Gly Thr Ser Ala Thr Thr Ala Ala Ile Gln Leu Met 
    370                 375                 380                 


Cys Ser Asp Ser Val Pro Cys Ser Asn Ile Lys Leu Ser Asn Val Phe 
385                 390                 395                 400 


Leu Lys Leu Thr Ser Gly Lys Val Ala Thr Cys Val Asn Lys Asn Ala 
                405                 410                 415     


Asn Gly Tyr Tyr Thr Asn Pro Leu Asn Pro Ser Cys Lys Ser Leu His 
            420                 425                 430         


Pro Gly Arg Thr Pro Lys Glu Leu Glu Leu His Gln Lys Pro Thr Thr 
        435                 440                 445             


Leu Leu Met Asp Glu Lys Met Gly Ala Ser Leu Asn Ser Ser Pro Pro 
    450                 455                 460                 


Asn Cys Lys Asn Lys Cys Lys Gly Cys Gln Pro Cys Lys Pro Lys Leu 
465                 470                 475                 480 


Ile Ile Val His Pro Asn Gln Pro Glu Asp Tyr Tyr Pro Gln Arg Trp 
                485                 490                 495     


Val Cys Ser Cys His Asn Lys Ile Tyr Asn Pro 
            500                 505         


<210>  239
<211>  384
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  239

His Asp Val Ala Ile Val Phe Asn Val Glu His His Gly Ala Val Gly 
1               5                   10                  15      


Asp Gly Asn His Asp Ser Thr Asp Ala Phe Glu Lys Thr Trp Asn Glu 
            20                  25                  30          


Ala Cys Lys Thr Leu Ser Ala Val Phe Leu Val Pro Ala Asn Lys Lys 
        35                  40                  45              


Phe Val Val Val Asn Asn Leu Val Phe Tyr Gly Pro Cys Gln Pro His 
    50                  55                  60                  


Phe Ser Pro Lys Val Asp Gly Ile Ile Ala Ala Tyr Pro Asp Pro Val 
65                  70                  75                  80  


Lys Trp Lys Asn Ser Lys Ile Trp Met His Phe Ala Arg Leu Thr Asp 
                85                  90                  95      


Phe Asn Leu Met Gly Thr Gly Val Ile Asp Gly Gln Gly Ser Lys Trp 
            100                 105                 110         


Trp Ser Asp Gln Cys Lys Thr Val Asn Gly Arg Thr Val Cys Asn Asp 
        115                 120                 125             


Lys Gly Arg Pro Thr Ala Ile Lys Ile Asp Phe Ser Lys Ser Val Thr 
    130                 135                 140                 


Val Lys Glu Leu Thr Leu Met Asn Ser Pro Glu Phe His Leu Val Phe 
145                 150                 155                 160 


Gly Glu Cys Asp Gly Val Lys Ile Gln Gly Ile Lys Ile Lys Ala Pro 
                165                 170                 175     


Lys Glu Ser Pro Asn Thr Asp Gly Ile Asp Ile Phe Gly Ser Lys Arg 
            180                 185                 190         


Phe Glu Ile Glu Lys Cys Ile Ile Gly Thr Gly Asp Asp Cys Val Ala 
        195                 200                 205             


Ile Gly Thr Gly Ser Ser Asn Ile Thr Ile Thr Asp Leu Thr Cys Gly 
    210                 215                 220                 


Pro Gly His Gly Met Ser Ile Gly Ser Leu Gly Lys Gly Asn Ser Arg 
225                 230                 235                 240 


Ser Glu Val Ser Phe Val His Leu Asp Gly Ala Lys Phe Ile Asp Thr 
                245                 250                 255     


Gln Asn Gly Leu Arg Ile Lys Thr Trp Gln Gly Gly Ser Gly Leu Ala 
            260                 265                 270         


Ser His Ile Thr Tyr Glu Asn Val Glu Met Val Asn Ala Glu Asn Pro 
        275                 280                 285             


Ile Leu Ile Asn Gln Phe Tyr Cys Thr Ser Ala Ala Cys Glu Asn Gln 
    290                 295                 300                 


Arg Ser Ala Val Lys Ile Glu Asp Val Trp Phe Lys Asn Ile His Gly 
305                 310                 315                 320 


Thr Ser Ala Thr Ala Ala Ala Ile Gln Leu Met Cys Ser Asp Ser Val 
                325                 330                 335     


Pro Cys Ser Asn Ile Lys Leu Ser Asn Val Val Leu Lys Leu Ser Ser 
            340                 345                 350         


Gly Lys Val Ala Ala Cys Val Asn Lys Asn Ala Asn Gly Tyr Tyr Thr 
        355                 360                 365             


Asn Pro Leu Asn Pro Pro Cys Lys Ser Leu His Pro Gly Pro Thr Pro 
    370                 375                 380                 


<210>  240
<211>  225
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  240

Met Ala Arg Val Ser Glu Leu Ala Phe Leu Leu Ala Ala Thr Leu Ala 
1               5                   10                  15      


Ile Ser Leu His Met Gln Glu Ala Gly Val Val Lys Phe Asp Ile Lys 
            20                  25                  30          


Asn Gln Cys Gly Tyr Thr Val Trp Ala Ala Gly Leu Pro Gly Gly Gly 
        35                  40                  45              


Lys Arg Leu Asp Gln Gly Gln Thr Trp Thr Val Asn Leu Ala Ala Gly 
    50                  55                  60                  


Thr Ala Ser Ala Arg Phe Trp Gly Arg Thr Gly Cys Thr Phe Asp Ala 
65                  70                  75                  80  


Ser Gly Lys Gly Ser Cys Gln Thr Gly Asp Cys Gly Gly Gln Leu Ser 
                85                  90                  95      


Cys Thr Val Ser Gly Ala Val Pro Ala Thr Leu Ala Glu Tyr Thr Gln 
            100                 105                 110         


Ser Asp Gln Asp Tyr Tyr Asp Val Ser Leu Val Asp Gly Phe Asn Ile 
        115                 120                 125             


Pro Leu Ala Ile Asn Pro Thr Asn Ala Gln Cys Thr Ala Pro Ala Cys 
    130                 135                 140                 


Lys Ala Asp Ile Asn Ala Val Cys Pro Ser Glu Leu Lys Val Asp Gly 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Cys Asn Val Phe Lys Thr Asp Gln Tyr Cys Cys 
                165                 170                 175     


Arg Asn Ala Tyr Val Asp Asn Cys Pro Ala Thr Asn Tyr Ser Lys Ile 
            180                 185                 190         


Phe Lys Asn Gln Cys Pro Gln Ala Tyr Ser Tyr Ala Lys Asp Asp Thr 
        195                 200                 205             


Ala Thr Phe Ala Cys Ala Ser Gly Thr Asp Tyr Ser Ile Val Phe Cys 
    210                 215                 220                 


Pro 
225 


<210>  241
<211>  225
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  241

Met Ala Arg Val Ser Glu Leu Ala Leu Leu Leu Val Ala Thr Leu Ala 
1               5                   10                  15      


Ile Ser Leu His Met Gln Glu Ala Gly Ala Val Lys Phe Asp Ile Lys 
            20                  25                  30          


Asn Gln Cys Gly Tyr Thr Val Trp Ala Ala Gly Leu Pro Gly Gly Gly 
        35                  40                  45              


Lys Arg Leu Asp Gln Gly Gln Thr Trp Thr Leu Asn Leu Ala Ala Gly 
    50                  55                  60                  


Thr Ala Ser Ala Arg Phe Trp Gly Arg Thr Gly Cys Thr Phe Asp Ala 
65                  70                  75                  80  


Ser Gly Lys Gly Ser Cys Lys Thr Gly Asp Cys Gly Gly Gln Leu Ser 
                85                  90                  95      


Cys Thr Val Ser Gly Ala Val Pro Ala Thr Leu Ala Glu Tyr Thr Gln 
            100                 105                 110         


Ser Asp Gln Asp Tyr Tyr Asp Val Ser Leu Val Asp Gly Phe Asn Ile 
        115                 120                 125             


Pro Leu Ala Ile Asn Pro Thr Asn Ala Gln Cys Thr Ala Pro Ala Cys 
    130                 135                 140                 


Lys Ala Asp Ile Asn Ala Val Cys Pro Ser Glu Leu Lys Val Glu Gly 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Cys Asn Val Phe Gln Thr Asp Gln Tyr Cys Cys 
                165                 170                 175     


Arg Asn Ala Tyr Val Asp Asn Cys Pro Ala Thr Asn Tyr Ser Lys Ile 
            180                 185                 190         


Phe Lys Asn Gln Cys Pro Gln Ala Tyr Ser Tyr Ala Lys Asp Asp Thr 
        195                 200                 205             


Ala Thr Phe Ala Cys Ala Ser Gly Thr Asp Tyr Ser Ile Val Phe Cys 
    210                 215                 220                 


Pro 
225 


<210>  242
<211>  224
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  242

Met Ala Arg Val Ser Glu Leu Ala Leu Leu Leu Val Ala Thr Leu Ala 
1               5                   10                  15      


Ile Ser Leu His Met Gln Glu Ala Gly Ala Val Lys Phe Asp Ile Lys 
            20                  25                  30          


Asn Gln Cys Gly Tyr Thr Val Trp Ala Ala Gly Leu Pro Gly Gly Gly 
        35                  40                  45              


Lys Arg Leu Asp Gln Gly Gln Thr Trp Thr Val Asn Leu Ala Ala Gly 
    50                  55                  60                  


Thr Ala Ser Ala Arg Phe Trp Gly Arg Thr Gly Cys Thr Phe Asp Ala 
65                  70                  75                  80  


Ser Gly Lys Gly Ser Cys Arg Ser Gly Asp Cys Gly Gly Gln Leu Ser 
                85                  90                  95      


Cys Thr Val Ser Gly Ala Val Pro Ala Thr Leu Ala Glu Tyr Thr Gln 
            100                 105                 110         


Ser Asp Lys Asp Tyr Tyr Asp Val Ser Leu Val Asp Gly Phe Asn Ile 
        115                 120                 125             


Pro Leu Ala Ile Asn Pro Thr Asn Thr Lys Cys Thr Ala Pro Ala Cys 
    130                 135                 140                 


Lys Ala Asp Ile Asn Ala Val Cys Pro Ser Glu Leu Lys Val Asp Gly 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Cys Asn Val Leu Gln Thr Asp Gln Tyr Cys Cys 
                165                 170                 175     


Arg Asn Ala Tyr Val Asp Asn Cys Pro Ala Thr Asn Tyr Ser Lys Ile 
            180                 185                 190         


Phe Lys Asn Gln Cys Pro Gln Ala Tyr Ser Tyr Ala Lys Asp Asp Thr 
        195                 200                 205             


Ala Thr Phe Ala Cys Ala Ser Gly Thr Asp Tyr Ser Ile Val Phe Cys 
    210                 215                 220                 


<210>  243
<211>  199
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  243

Val Lys Phe Asp Ile Lys Asn Gln Cys Gly Tyr Thr Val Trp Ala Ala 
1               5                   10                  15      


Gly Leu Pro Gly Gly Gly Lys Glu Phe Asp Gln Gly Gln Thr Trp Thr 
            20                  25                  30          


Val Asn Leu Ala Ala Gly Thr Ala Ser Ala Arg Phe Trp Gly Arg Thr 
        35                  40                  45              


Gly Cys Thr Phe Asp Ala Ser Gly Lys Gly Ser Cys Arg Ser Gly Asp 
    50                  55                  60                  


Cys Gly Gly Gln Leu Ser Cys Thr Val Ser Gly Ala Val Pro Ala Thr 
65                  70                  75                  80  


Leu Ala Glu Tyr Thr Gln Ser Asp Gln Asp Tyr Tyr Asp Val Ser Leu 
                85                  90                  95      


Val Asp Gly Phe Asn Ile Pro Leu Ala Ile Asn Pro Thr Asn Thr Lys 
            100                 105                 110         


Cys Thr Ala Pro Ala Cys Lys Ala Asp Ile Asn Ala Val Cys Pro Ser 
        115                 120                 125             


Glu Leu Lys Val Asp Gly Gly Cys Asn Ser Ala Cys Asn Val Leu Gln 
    130                 135                 140                 


Thr Asp Gln Tyr Cys Cys Arg Asn Ala Tyr Val Asn Asn Cys Pro Ala 
145                 150                 155                 160 


Thr Asn Tyr Ser Lys Ile Phe Lys Asn Gln Cys Pro Gln Ala Tyr Ser 
                165                 170                 175     


Tyr Ala Lys Asp Asp Thr Ala Thr Phe Ala Cys Ala Ser Gly Thr Asp 
            180                 185                 190         


Tyr Ser Ile Val Phe Cys Pro 
        195                 


<210>  244
<211>  274
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  244

Met Gly Asn Ser Ser Gly Asn Ser Leu Met Val Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Leu Val Gly Val Thr Val Asn Ala Gln Asn Cys Gly Cys Ala Ser 
            20                  25                  30          


Gly Leu Cys Cys Ser Gln Tyr Gly Tyr Cys Gly Ser Ser Ser Ala Tyr 
        35                  40                  45              


Cys Gly Ala Gly Cys Lys Ser Gly Pro Cys Ser Gly Gly Gly Ser Pro 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Val Gly Thr Ile Ile Ser Gln Ser Phe Phe 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Gly Ala Ala Ser Ser Cys Glu Gly Lys Gly Phe 
                85                  90                  95      


Tyr Thr Tyr Asn Ala Phe Ile Ala Ala Ala Asn Ala Tyr Ser Gly Phe 
            100                 105                 110         


Gly Thr Thr Gly Ser Ala Asp Val Thr Lys Arg Glu Leu Ala Ala Phe 
        115                 120                 125             


Leu Ala Asn Val Met His Gly Thr Gly Gly Met Cys Tyr Ile Asn Glu 
    130                 135                 140                 


Arg Thr Pro Pro Met Ile Tyr Cys Met Ser Ser Ala Thr Trp Pro Cys 
145                 150                 155                 160 


Ala Ser Gly Lys Ser Tyr His Gly Arg Gly Pro Leu Gln Leu Ser Trp 
                165                 170                 175     


Asn Tyr Asn Tyr Gly Ala Ala Gly Gln Ser Ile Gly Phe Asp Gly Val 
            180                 185                 190         


Asn Asn Pro Glu Lys Val Gly Gln Asp Ser Thr Ile Ser Phe Lys Thr 
        195                 200                 205             


Ala Val Trp Phe Trp Met Lys Asn Ser Asn Cys His Ser Ala Ile Thr 
    210                 215                 220                 


Ser Gly Gln Gly Phe Gly Gly Thr Ile Lys Ala Ile Asn Ser Gln Glu 
225                 230                 235                 240 


Cys Asn Gly Gly Asn Ser Gly Glu Val Asn Ser Arg Val Asn Tyr Tyr 
                245                 250                 255     


Lys Asn Ile Cys Ser Gln Leu Gly Val Asp Pro Gly Ala Asn Leu Ser 
            260                 265                 270         


Cys His 
        


<210>  245
<211>  277
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  245

Met Gly Lys Thr Gly Gly Glu Lys Trp Val Met Ala Leu Val Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Gly Val Ser Val Asn Ala Gln Asn Cys Gly Cys Ala 
            20                  25                  30          


Ser Gly Leu Cys Cys Ser Lys Tyr Gly Tyr Cys Gly Thr Thr Ser Ala 
        35                  40                  45              


Tyr Cys Gly Thr Gly Cys Arg Ser Gly Pro Cys Ser Ser Asn Ser Gly 
    50                  55                  60                  


Gly Gly Ser Pro Ser Gly Gly Gly Gly Ser Val Gly Thr Ile Ile Ser 
65                  70                  75                  80  


Gln Ser Ile Phe Asn Gly Leu Ala Gly Gly Ala Ala Ser Ser Cys Glu 
                85                  90                  95      


Gly Lys Gly Phe Tyr Thr Tyr Thr Ala Phe Ile Lys Ala Ala Ser Ala 
            100                 105                 110         


Tyr Ser Gly Phe Gly Thr Thr Gly Ser Asn Asp Val Lys Lys Arg Glu 
        115                 120                 125             


Leu Ala Ala Phe Phe Ala Asn Val Met His Glu Thr Gly Gly Leu Cys 
    130                 135                 140                 


Tyr Ile Asn Glu Arg Asn Pro Pro Met Ile Tyr Cys Asn Ser Ser Ser 
145                 150                 155                 160 


Thr Trp Pro Cys Ala Ser Gly Lys Ser Tyr His Gly Arg Gly Pro Leu 
                165                 170                 175     


Gln Leu Ser Trp Asn Tyr Asn Tyr Gly Ala Ala Gly Lys Ser Ile Gly 
            180                 185                 190         


Phe Asp Gly Leu Asn Asn Pro Glu Lys Val Gly Gln Asp Ala Thr Ile 
        195                 200                 205             


Ser Phe Lys Thr Ala Val Trp Phe Trp Met Asn Asn Ser Asn Cys His 
    210                 215                 220                 


Ser Ala Ile Thr Gly Gly Gln Gly Phe Gly Ala Thr Ile Lys Ala Ile 
225                 230                 235                 240 


Asn Ser Gly Glu Cys Asn Gly Gly Asn Ser Gly Glu Val Ser Ser Arg 
                245                 250                 255     


Val Asn Tyr Tyr Arg Lys Ile Cys Ser Gln Leu Gly Val Asp Pro Gly 
            260                 265                 270         


Ala Asn Val Ser Cys 
        275         


<210>  246
<211>  308
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  246

Met Gly Ser Arg Ser Arg Ile Leu Leu Ile Gly Ala Thr Gly Tyr Ile 
1               5                   10                  15      


Gly Arg His Val Ala Lys Ala Ser Leu Asp Leu Gly His Pro Thr Phe 
            20                  25                  30          


Leu Leu Val Arg Glu Ser Thr Ala Ser Ser Asn Ser Glu Lys Ala Gln 
        35                  40                  45              


Leu Leu Glu Ser Phe Lys Ala Ser Gly Ala Asn Ile Val His Gly Ser 
    50                  55                  60                  


Ile Asp Asp His Ala Ser Leu Val Glu Ala Val Lys Asn Val Asp Val 
65                  70                  75                  80  


Val Ile Ser Thr Val Gly Ser Leu Gln Ile Glu Ser Gln Val Asn Ile 
                85                  90                  95      


Ile Lys Ala Ile Lys Glu Val Gly Thr Val Lys Arg Phe Phe Pro Ser 
            100                 105                 110         


Glu Phe Gly Asn Asp Val Asp Asn Val His Ala Val Glu Pro Ala Lys 
        115                 120                 125             


Ser Val Phe Glu Val Lys Ala Lys Val Arg Arg Ala Ile Glu Ala Glu 
    130                 135                 140                 


Gly Ile Pro Tyr Thr Tyr Val Ser Ser Asn Cys Phe Ala Gly Tyr Phe 
145                 150                 155                 160 


Leu Arg Ser Leu Ala Gln Ala Gly Leu Thr Ala Pro Pro Arg Asp Lys 
                165                 170                 175     


Val Val Ile Leu Gly Asp Gly Asn Ala Arg Val Val Phe Val Lys Glu 
            180                 185                 190         


Glu Asp Ile Gly Thr Phe Thr Ile Lys Ala Val Asp Asp Pro Arg Thr 
        195                 200                 205             


Leu Asn Lys Thr Leu Tyr Leu Arg Leu Pro Ala Asn Thr Leu Ser Leu 
    210                 215                 220                 


Asn Glu Leu Val Ala Leu Trp Glu Lys Lys Ile Asp Lys Thr Leu Glu 
225                 230                 235                 240 


Lys Ala Tyr Val Pro Glu Glu Glu Val Leu Lys Leu Ile Ala Asp Thr 
                245                 250                 255     


Pro Phe Pro Ala Asn Ile Ser Ile Ala Ile Ser His Ser Ile Phe Val 
            260                 265                 270         


Lys Gly Asp Gln Thr Asn Phe Glu Ile Gly Pro Ala Gly Val Glu Ala 
        275                 280                 285             


Ser Gln Leu Tyr Pro Asp Val Lys Tyr Thr Thr Val Asp Glu Tyr Leu 
    290                 295                 300                 


Ser Asn Phe Val 
305             


<210>  247
<211>  173
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  247

Met Asp Ser Arg Arg Leu Lys Arg Ser Gly Ile Val Cys Met Val Leu 
1               5                   10                  15      


Met Ser Met Leu Met Leu Val Val Cys Glu Asp Ser Asp Asn Thr Ala 
            20                  25                  30          


Cys Leu Ser Ser Leu Ser Ser Cys Ala Pro Tyr Leu Asn Ala Thr Thr 
        35                  40                  45              


Lys Pro Asp Ser Ser Cys Cys Ser Ala Leu Ile Ser Val Ile Asp Lys 
    50                  55                  60                  


Asp Ser Gln Cys Leu Cys Asn Leu Leu Asn Ser Asp Thr Val Lys Gln 
65                  70                  75                  80  


Leu Gly Val Asn Val Thr Gln Ala Met Lys Met Pro Ala Glu Cys Gly 
                85                  90                  95      


Lys Asn Val Ser Ala Thr Gln Cys Asn Lys Thr Ala Thr Ser Gly Gly 
            100                 105                 110         


Ser Ser Val Gly Lys Thr Pro Thr Ser Thr Pro Pro Pro Ser Ser Ala 
        115                 120                 125             


Thr Pro Ser Thr Thr Thr Ile Thr Lys Ser Asn Ser Asn Ala Ala Ala 
    130                 135                 140                 


Ser Val Ser Val Lys Met Phe Pro Val Ala Ala Leu Val Phe Val Ala 
145                 150                 155                 160 


Val Ala Ser Val Leu Gly Leu Lys Gly Pro Cys Leu Arg 
                165                 170             


<210>  248
<211>  124
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  248

Met Arg Arg Glu Arg Gly Arg Gln Gly Asp Ser Ser Ser Cys Glu Arg 
1               5                   10                  15      


Gln Val Asp Arg Val Asn Leu Lys Pro Cys Glu Gln His Ile Met Gln 
            20                  25                  30          


Arg Ile Met Gly Glu Gln Glu Gln Tyr Asp Ser Tyr Asp Ile Arg Ser 
        35                  40                  45              


Thr Arg Ser Ser Asp Gln Gln Gln Arg Cys Cys Asp Glu Leu Asn Glu 
    50                  55                  60                  


Met Glu Asn Thr Gln Arg Cys Met Cys Glu Ala Leu Gln Gln Ile Met 
65                  70                  75                  80  


Glu Asn Gln Cys Asp Arg Leu Gln Asp Arg Gln Met Val Gln Gln Phe 
                85                  90                  95      


Lys Arg Glu Leu Met Asn Leu Pro Gln Gln Cys Asn Phe Arg Ala Pro 
            100                 105                 110         


Gln Arg Cys Asp Leu Asp Val Ser Gly Gly Arg Cys 
        115                 120                 


<210>  249
<211>  157
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  249

Met Gly Val Phe Thr Phe Glu Asp Glu Ile Thr Ser Thr Val Pro Pro 
1               5                   10                  15      


Ala Lys Leu Tyr Asn Ala Met Lys Asp Ala Asp Ser Ile Thr Pro Lys 
            20                  25                  30          


Ile Ile Asp Asp Val Lys Ser Val Glu Ile Val Glu Gly Asn Gly Gly 
        35                  40                  45              


Pro Gly Thr Ile Lys Lys Leu Thr Ile Val Glu Asp Gly Glu Thr Lys 
    50                  55                  60                  


Phe Ile Leu His Lys Val Glu Ser Ile Asp Glu Ala Asn Tyr Ala Tyr 
65                  70                  75                  80  


Asn Tyr Ser Val Val Gly Gly Val Ala Leu Pro Pro Thr Ala Glu Lys 
                85                  90                  95      


Ile Thr Phe Glu Thr Lys Leu Val Glu Gly Pro Asn Gly Gly Ser Ile 
            100                 105                 110         


Gly Lys Leu Thr Leu Lys Tyr His Thr Lys Gly Asp Ala Lys Pro Asp 
        115                 120                 125             


Glu Glu Glu Leu Lys Lys Gly Lys Ala Lys Gly Glu Gly Leu Phe Arg 
    130                 135                 140                 


Ala Ile Glu Gly Tyr Val Leu Ala Asn Pro Thr Gln Tyr 
145                 150                 155         


<210>  250
<211>  92
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic

<400>  250

Ile Ser Cys Gly Gln Val Asn Ser Ala Leu Ala Pro Cys Ile Pro Phe 
1               5                   10                  15      


Leu Thr Lys Gly Gly Ala Pro Pro Pro Ala Cys Cys Ser Gly Val Arg 
            20                  25                  30          


Gly Leu Leu Gly Ala Leu Arg Thr Thr Ala Asp Arg Gln Ala Ala Cys 
        35                  40                  45              


Asn Cys Leu Lys Ala Ala Ala Gly Ser Leu Arg Gly Leu Asn Gln Gly 
    50                  55                  60                  


Asn Ala Ala Ala Leu Pro Gly Arg Cys Gly Val Ser Ile Pro Tyr Lys 
65                  70                  75                  80  


Ile Ser Thr Ser Thr Asn Cys Ala Thr Ile Lys Phe 
                85                  90          


