                         SEQUENCE LISTING

<110>  Hadasit Medical Research Services and Development Ltd.
       BEN YEHUDA, Dina
       ABD-ELRAHMAN, Ihab
       PERLMAN, Riki
       NACHMIAS, Boaz
       BENITA, Simon
       NASSAR, Taher
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER RESISTANT TO AN 
       ANTI-CANCER AGENT

<130>  77314

<150>  US 62/671,454
<151>  2018-05-15

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tLivin alpha nucleotide sequence

<400>  1
gggcagatcc tgggccagct gcggcccctg acagaggagg aagaggagga gggcgccggg       60

gccaccttgt ccagggggcc tgccttcccc ggcatgggct ctgaggagtt gcgtctggcc      120

tccttctatg actggccgct gactgctgag gtgccacccg agctgctggc tgctgccggc      180

ttcttccaca caggccatca ggacaaggtg aggtgcttct tctgctatgg gggcctgcag      240

agctggaagc gcggggacga cccctggacg gagcatgcca agtggttccc cagctgtcag      300

ttcctgctcc ggtcaaaagg aagagacttt gtccacagtg tgcaggagac tcactcccag      360

ctgctgggct cctgggaccc gtgggaagaa ccggaagacg cagcccctgt ggccccctcc      420

gtccctgcct ctgggtaccc tcgagctgcc cacacccagg agagaggtcc agtctgaaag      480

tgcccaggag ccaggagggg tcagtccagc cgaggcccag agggcgtggt gggttcttga      540

gcccccagga gccagggatg tggaggcgca gctgcggcgg ctgcaggagg agaggacgtg      600

caaggtgtgc ctggaccgcg ccgtgtccat cgtctttgtg ccgtgcggcc acctggtctg      660

tgctgagtgt gcccccggcc tgcagctgtg ccccatctgc agagcccccg tccgcagccg      720

cgtgcgcacc ttcctgtcct aggccaggtg c                                     751


<210>  2
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tLivin alpha AA sequence

<400>  2

Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala Phe Pro Gly Met 
            20                  25                  30          


Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp Trp Pro Leu Thr 
        35                  40                  45              


Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly Phe Phe His Thr 
    50                  55                  60                  


Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr Gly Gly Leu Gln 
65                  70                  75                  80  


Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His Ala Lys Trp Phe 
                85                  90                  95      


Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg Asp Phe Val His 
            100                 105                 110         


Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser Trp Asp Pro Trp 
        115                 120                 125             


Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser Val Pro Ala Ser 
    130                 135                 140                 


Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val Gln Ser Glu Ser 
145                 150                 155                 160 


Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala Gln Arg Ala Trp 
                165                 170                 175     


Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu Ala Gln Leu Arg 
            180                 185                 190         


Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu Asp Arg Ala Val 
        195                 200                 205             


Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys Ala Glu Cys Ala 
    210                 215                 220                 


Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro Val Arg Ser Arg 
225                 230                 235                 240 


Val Arg Thr Phe Leu Ser 
                245     


<210>  3
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tLivin beta nucleotide sequence

<400>  3
gggcagatcc tgggccagct gcggcccctg acagaggagg aagaggagga gggcgccggg       60

gccaccttgt ccagggggcc tgccttcccc ggcatgggct ctgaggagtt gcgtctggcc      120

tccttctatg actggccgct gactgctgag gtgccacccg agctgctggc tgctgccggc      180

ttcttccaca caggccatca ggacaaggtg aggtgcttct tctgctatgg gggcctgcag      240

agctggaagc gcggggacga cccctggacg gagcatgcca agtggttccc cagctgtcag      300

ttcctgctcc ggtcaaaagg aagagacttt gtccacagtg tgcaggagac tcactcccag      360

ctgctgggct cctgggaccc gtgggaagaa ccggaagacg cagcccctgt ggccccctcc      420

gtccctgcct ctgggtaccc tgagctgccc acacccagga gagaggtcca gtctgaaagt      480

gcccaggagc caggagccag ggatgtggag gcgcagctgc ggcggctgca ggaggagagg      540

acgtgcaagg tgtgcctgga ccgcgccgtg tccatcgtct ttgtgccgtg cggccacctg      600

gtctgtgctg agtgtgcccc cggcctgcag ctgtgcccca tctgcagagc ccccgtccgc      660

agccgcgtgc gcaccttcct gtcctag                                          687


<210>  4
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tLivin beta AA sequence

<400>  4

Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala Phe Pro Gly Met 
            20                  25                  30          


Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp Trp Pro Leu Thr 
        35                  40                  45              


Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly Phe Phe His Thr 
    50                  55                  60                  


Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr Gly Gly Leu Gln 
65                  70                  75                  80  


Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His Ala Lys Trp Phe 
                85                  90                  95      


Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg Asp Phe Val His 
            100                 105                 110         


Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser Trp Asp Pro Trp 
        115                 120                 125             


Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser Val Pro Ala Ser 
    130                 135                 140                 


Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val Gln Ser Glu Ser 
145                 150                 155                 160 


Ala Gln Glu Pro Gly Ala Arg Asp Val Glu Ala Gln Leu Arg Arg Leu 
                165                 170                 175     


Gln Glu Glu Arg Thr Cys Lys Val Cys Leu Asp Arg Ala Val Ser Ile 
            180                 185                 190         


Val Phe Val Pro Cys Gly His Leu Val Cys Ala Glu Cys Ala Pro Gly 
        195                 200                 205             


Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro Val Arg Ser Arg Val Arg 
    210                 215                 220                 


Thr Phe Leu Ser 
225             


<210>  5
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mtLivin NA sequence

<400>  5
atggggcaga tcctgggcca gctgcggccc ctgacagagg cgcagctgag gcggctgcag       60

gaggagagga cgtgcaaggt gtgcctggac cgcgccgtgt ccatcgtctt tgtgccgtgc      120

ggccacctgg tctgtgctga gtgtgccccc ggcctgcagc tgtgccccat ctgcagagcc      180

cccgtccgca gccgcgtgcg caccttcctg tcctag                                216


<210>  6
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mtLivin AA sequence

<400>  6

Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu Ala Gln Leu Arg 
1               5                   10                  15      


Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu Asp Arg Ala Val 
            20                  25                  30          


Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys Ala Glu Cys Ala 
        35                  40                  45              


Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro Val Arg Ser Arg 
    50                  55                  60                  


Val Arg Thr Phe Leu Ser 
65                  70  


<210>  7
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mtLivin NA with a his tag and TEV cleavage sequence

<400>  7
atgggcagca gccatcatca tcatcatcac tccgcgggtg aaaacctgta cttccagggg       60

cagatcctgg gccagctgcg gcccctgaca gaggcgcagc tgaggcggct gcaggaggag      120

aggacgtgca aggtgtgcct ggaccgcgcc gtgtccatcg tctttgtgcc gtgcggccac      180

ctggtctgtg ctgagtgtgc ccccggcctg cagctgtgcc ccatctgcag agcccccgtc      240

cgcagccgcg tgcgcacctt cctgtcctag                                       270


<210>  8
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mtLivin AA with a his tag and TEV cleavage sequence

<400>  8

Met Glu Thr Gly Ser Ser His His His His His His Ser Ala Gly Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr 
            20                  25                  30          


Glu Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys 
        35                  40                  45              


Leu Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val 
    50                  55                  60                  


Cys Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala 
65                  70                  75                  80  


Pro Val Arg Ser Arg Val Arg Thr Phe Leu Ser 
                85                  90      


<210>  9
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L polypeptide amino acid sequence

<400>  9

Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
1               5                   10                  15      


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
        35                  40                  45              


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
    50                  55                  60                  


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
65                  70                  75                  80  


Leu Trp Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
                85                  90                  95      


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
            100                 105                 110         


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
        115                 120                 125             


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
    130                 135                 140                 


Gly Leu Leu Lys Leu 
145                 


