                         SEQUENCE LISTING

<110>  HYPHA DISCOVERY LTD et al.
 
<120>  HYDROXYLATION TECHNIQUES

<130>  JWJ02469WO

<150>  GB1807815.4
<151>  2018-05-14

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  2793
<212>  DNA
<213>  Amycolatopsis lurida

<400>  1
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa acggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtaggagga gccatgaaga tcatcgcgga caccgggaaa tgcgtgggcg     1260

cgggccagtg cgtgctcacc gatcccgatc tgttcgatca gagcgaggac gacggaacgg     1320

tcctcgtgct gaacgccgag cctgaaggcg aagaggcgga agaaaacgcc cgcaccgccg     1380

tgcacatctg cccggggcag gccttgtcgc tcgcttaata ggaagcttat gccccgccct     1440

ctgcgggtag ccatcgtcgg atccggcccg gccgggatct acgccgccga cgccctgctc     1500

aagtccgaag tggccgccga ccccggtgtt tccatcgaca tcttcgagcg catgcccgcc     1560

ccgttcggcc tcatccggta cggcgtcgcg cccgaccacc cgcggatcaa gggcatcatc     1620

acggccctcc accaggtgct cgacaagccg cagatccgcc tcttcggcaa cgtgaactac     1680

cccaccgacg tcagcctgga cgatctgcgc gccttctacg acggtgtgat cttcgccacc     1740

ggcgccacgg cggaccggga cctgtccctc ccgggcatcg acctcgacgg ctcgtacggc     1800

gcggccgact tcgtcgcctg gtacgacggc caccccgact tcccgcgcac ctggccgctg     1860

gaggcggaga aagtcgccgt cctcggtgtc ggcaacgtcg ccctggacat cgcgcgcgtc     1920

ctcgccaaga cggccgacga gctgctgccg accgagatcc cgccgaacgt ctacgagggc     1980

ctcaaggcca acaaggcgct ggaggtgcac gtcttcggcc gccgcggccc ggcgcaggcg     2040

aagttcagcc cgatggagct gcgggagctg gaccactccc ccaacatcga ggtgatcgtc     2100

gaccccgagg acatcgacta cgacgagggc tcgatcgcga cccggcgcgg caacaagcag     2160

gccgacatgg tcgccaagac cctggagaac tgggcgatcc gcgacgtcgg cgaccggccg     2220

cacaagctct tcctgcactt cttcgagtcg cccgcggaga tcctcggcga ggacggcagg     2280

gtgaccggcc tgcgcaccga gcgcacggag ctggacggca cgggcaacgt caagggcacc     2340

ggcgagttca aggactggga cgtccaggcg gtctaccggg ccgtcggcta cctctccgac     2400

cagctgccca agctgccctg ggacctcgag acgtgcacgg tcccggacgc gggcggccgg     2460

gtcgtccagg agtccggcga gcacctccag tcgacgtacg tcaccggctg gatccggcgc     2520

ggtccgatcg gcctgatcgg ccacaccaag ggcgacgcca acgagacggt gtccaacctg     2580

ctggacgact acgcgaacgg ccgtctccag acgccctcct cccccgctcc cgaggccgtg     2640

gacgcgttcc tcgccgagcg gaacgtccgc ttcaccacct gggacggctg gtaccggctc     2700

gacgccgcgg agaaggcgca gggcgaaccg cacgggcgtg agcgcgtgaa gtacgtcgag     2760

cgcgaggaca tgctccgcga gagcggcgcc tga                                  2793


<210>  2
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  2

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Thr Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  3
<211>  64
<212>  PRT
<213>  Amycolatopsis lurida

<400>  3

Met Lys Ile Ile Ala Asp Thr Gly Lys Cys Val Gly Ala Gly Gln Cys 
1               5                   10                  15      


Val Leu Thr Asp Pro Asp Leu Phe Asp Gln Ser Glu Asp Asp Gly Thr 
            20                  25                  30          


Val Leu Val Leu Asn Ala Glu Pro Glu Gly Glu Glu Ala Glu Glu Asn 
        35                  40                  45              


Ala Arg Thr Ala Val His Ile Cys Pro Gly Gln Ala Leu Ser Leu Ala 
    50                  55                  60                  


<210>  4
<211>  454
<212>  PRT
<213>  Amycolatopsis lurida

<400>  4

Met Pro Arg Pro Leu Arg Val Ala Ile Val Gly Ser Gly Pro Ala Gly 
1               5                   10                  15      


Ile Tyr Ala Ala Asp Ala Leu Leu Lys Ser Glu Val Ala Ala Asp Pro 
            20                  25                  30          


Gly Val Ser Ile Asp Ile Phe Glu Arg Met Pro Ala Pro Phe Gly Leu 
        35                  40                  45              


Ile Arg Tyr Gly Val Ala Pro Asp His Pro Arg Ile Lys Gly Ile Ile 
    50                  55                  60                  


Thr Ala Leu His Gln Val Leu Asp Lys Pro Gln Ile Arg Leu Phe Gly 
65                  70                  75                  80  


Asn Val Asn Tyr Pro Thr Asp Val Ser Leu Asp Asp Leu Arg Ala Phe 
                85                  90                  95      


Tyr Asp Gly Val Ile Phe Ala Thr Gly Ala Thr Ala Asp Arg Asp Leu 
            100                 105                 110         


Ser Leu Pro Gly Ile Asp Leu Asp Gly Ser Tyr Gly Ala Ala Asp Phe 
        115                 120                 125             


Val Ala Trp Tyr Asp Gly His Pro Asp Phe Pro Arg Thr Trp Pro Leu 
    130                 135                 140                 


Glu Ala Glu Lys Val Ala Val Leu Gly Val Gly Asn Val Ala Leu Asp 
145                 150                 155                 160 


Ile Ala Arg Val Leu Ala Lys Thr Ala Asp Glu Leu Leu Pro Thr Glu 
                165                 170                 175     


Ile Pro Pro Asn Val Tyr Glu Gly Leu Lys Ala Asn Lys Ala Leu Glu 
            180                 185                 190         


Val His Val Phe Gly Arg Arg Gly Pro Ala Gln Ala Lys Phe Ser Pro 
        195                 200                 205             


Met Glu Leu Arg Glu Leu Asp His Ser Pro Asn Ile Glu Val Ile Val 
    210                 215                 220                 


Asp Pro Glu Asp Ile Asp Tyr Asp Glu Gly Ser Ile Ala Thr Arg Arg 
225                 230                 235                 240 


Gly Asn Lys Gln Ala Asp Met Val Ala Lys Thr Leu Glu Asn Trp Ala 
                245                 250                 255     


Ile Arg Asp Val Gly Asp Arg Pro His Lys Leu Phe Leu His Phe Phe 
            260                 265                 270         


Glu Ser Pro Ala Glu Ile Leu Gly Glu Asp Gly Arg Val Thr Gly Leu 
        275                 280                 285             


Arg Thr Glu Arg Thr Glu Leu Asp Gly Thr Gly Asn Val Lys Gly Thr 
    290                 295                 300                 


Gly Glu Phe Lys Asp Trp Asp Val Gln Ala Val Tyr Arg Ala Val Gly 
305                 310                 315                 320 


Tyr Leu Ser Asp Gln Leu Pro Lys Leu Pro Trp Asp Leu Glu Thr Cys 
                325                 330                 335     


Thr Val Pro Asp Ala Gly Gly Arg Val Val Gln Glu Ser Gly Glu His 
            340                 345                 350         


Leu Gln Ser Thr Tyr Val Thr Gly Trp Ile Arg Arg Gly Pro Ile Gly 
        355                 360                 365             


Leu Ile Gly His Thr Lys Gly Asp Ala Asn Glu Thr Val Ser Asn Leu 
    370                 375                 380                 


Leu Asp Asp Tyr Ala Asn Gly Arg Leu Gln Thr Pro Ser Ser Pro Ala 
385                 390                 395                 400 


Pro Glu Ala Val Asp Ala Phe Leu Ala Glu Arg Asn Val Arg Phe Thr 
                405                 410                 415     


Thr Trp Asp Gly Trp Tyr Arg Leu Asp Ala Ala Glu Lys Ala Gln Gly 
            420                 425                 430         


Glu Pro His Gly Arg Glu Arg Val Lys Tyr Val Glu Arg Glu Asp Met 
        435                 440                 445             


Leu Arg Glu Ser Gly Ala 
    450                 


<210>  5
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  5
gatcgcggaa gatgcgacct cac                                               23


<210>  6
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  6
gtgaggtcgc atcttccgcg atc                                               23


<210>  7
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  7
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gatgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  8
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  8

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Asp Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  9
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  9
gatcgcggaa gaagcgacct cac                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  10
gtgaggtcgc ttcttccgcg atc                                               23


<210>  11
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  11
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  12
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  12

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  13
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  13
gatcgcggaa aacgcgacct cac                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  14
gtgaggtcgc gttttccgcg atc                                               23


<210>  15
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  15
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa aacgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  16
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  16

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Asn Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  17
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  17
gatcgcggaa caggcgacct cac                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  18
gtgaggtcgc ctgttccgcg atc                                               23


<210>  19
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  19
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa caggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  20
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  20

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Gln Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  21
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  21
gatcgcggaa gcggcgacct cac                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  22
gtgaggtcgc cgcttccgcg atc                                               23


<210>  23
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  23
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gcggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  24
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  24

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Ala Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  25
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  25
gatcgcggaa gtggcgacct cac                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  26
gtgaggtcgc cacttccgcg atc                                               23


<210>  27
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  27
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gtggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  28
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  28

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Val Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  29
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  29
gatcgcggaa tatgcgacct cac                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  30
gtgaggtcgc atattccgcg atc                                               23


<210>  31
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  31
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa tatgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  32
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  32

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Tyr Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  33
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  33
gatcgcggaa agcgcgacct cac                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  34
gtgaggtcgc gctttccgcg atc                                               23


<210>  35
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  35
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa agcgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  36
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  36

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Ser Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  37
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  37
gatcgcggaa ctggcgacct cac                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  38
gtgaggtcgc cagttccgcg atc                                               23


<210>  39
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  39
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa ctggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  40
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  40

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Leu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  41
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  41
gatcgcggaa attgcgacct cac                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  42
gtgaggtcgc aatttccgcg atc                                               23


<210>  43
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  43
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa attgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  44
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  44

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Ile Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  45
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  45
gatcgcggaa atggcgacct cac                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  46
gtgaggtcgc catttccgcg atc                                               23


<210>  47
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  47
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa atggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  48
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  48

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Met Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  49
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  49
gatcgcggaa ccggcgacct cac                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  50
gtgaggtcgc cggttccgcg atc                                               23


<210>  51
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  51
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa ccggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  52
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  52

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Pro Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  53
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  53
gatcgcggaa tttgcgacct cac                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  54
gtgaggtcgc aaattccgcg atc                                               23


<210>  55
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  55
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa tttgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  56
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  56

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Phe Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  57
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  57
gatcgcggaa tgggcgacct cac                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  58
gtgaggtcgc ccattccgcg atc                                               23


<210>  59
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  59
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa tgggcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  60
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  60

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Trp Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  61
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  61
gatcgcggaa catgcgacct cac                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  62
gtgaggtcgc atgttccgcg atc                                               23


<210>  63
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  63
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa catgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  64
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  64

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu His Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  65
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  65
gatcgcggaa aaagcgacct cac                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  66
gtgaggtcgc tttttccgcg atc                                               23


<210>  67
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  67
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa aaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  68
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  68

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Lys Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  69
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  69
gatcgcggaa cgcgcgacct cac                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  70
gtgaggtcgc gcgttccgcg atc                                               23


<210>  71
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  71
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa cgcgcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  72
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  72

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Arg Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  73
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  73
aacggcttgg tggctcaccc ggc                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  74
gccgggtgag ccaccaagcc gtt                                               23


<210>  75
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  75
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttggtg gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  76
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  76

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Trp Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  77
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  77
aacggcttgg tttctcaccc ggc                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  78
gccgggtgag aaaccaagcc gtt                                               23


<210>  79
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  79
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttggtt tctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  80
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  80

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Phe Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  81
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  81
aacggcttgg attctcaccc ggc                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  82
gccgggtgag aatccaagcc gtt                                               23


<210>  83
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  83
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttggat tctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  84
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  84

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ile Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  85
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  85
gttcccgctg tttgtcgcgc ggc                                               23


<210>  86
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  86
gccgcgcgac aaacagcggg aac                                               23


<210>  87
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  87
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgtttgtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  88
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  88

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Phe Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  89
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  89
gttcccgctg tgggtcgcgc ggc                                               23


<210>  90
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  90
gccgcgcgac ccacagcggg aac                                               23


<210>  91
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  91
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgtgggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  92
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  92

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Trp Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  93
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  93
gttcccgctg gcggtcgcgc ggc                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  94
gccgcgcgac cgccagcggg aac                                               23


<210>  95
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  95
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tggcggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggtgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  96
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  96

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Ala Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Val Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  97
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  97
ggaaggggtg attggcctga gca                                               23


<210>  98
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  98
tgctcaggcc aatcacccct tcc                                               23


<210>  99
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  99
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tgattggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  100
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  100

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Ile Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  101
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  101
ggaaggggtg gcgggcctga gca                                               23


<210>  102
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  102
tgctcaggcc cgccacccct tcc                                               23


<210>  103
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  103
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tggcgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  104
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  104

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Ala Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  105
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  105
ggaaggggtg ctgggcctga gca                                               23


<210>  106
<211>  23
<212>  DNA
<213>  Artifical Sequence

<400>  106
tgctcaggcc cagcacccct tcc                                               23


<210>  107
<211>  1215
<212>  DNA
<213>  Amycolatopsis lurida

<400>  107
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc gctcacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgatggtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa gaagcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tgctgggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtag                                                      1215


<210>  108
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida

<400>  108

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Ala Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Met Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Glu Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Leu Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


<210>  109
<211>  1418
<212>  DNA
<213>  Amycolatopsis lurida


<220>
<221>  misc_feature
<222>  (141)..(143)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (223)..(225)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (871)..(873)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (943)..(945)
<223>  n is a, c, g, or t

<400>  109
atgactgacg tcgaggaaac caccgcgacc ttgccgctgg cccggaaatg cccgttttcg       60

ccgccgcccg aatacgaacg gcttcgccgg gaaagtccgg tttcccgggt cggtctcccg      120

tccggtcaaa cggcttgggc nnncacccgg ctcgaagaca tccgcgaaat gctgagcagc      180

ccgcatttca gttccgaccg gcagagcccg tcgttcccgc tgnnngtcgc gcggcagatc      240

cgccgcgagg acaagccgtt ccgcccctcc ctcatcgcga tggatccgcc ggaacacagc      300

cgggccaggc gtgacgtcgt cggggaattc accgtcaagc ggatgaaggc gctccagccg      360

cgaattcagc agatcgtcga cgaacatctc gacgccctgc tcgcgggccc caaacccgcc      420

gatctcgtcc aggcgctttc cctgcccgtt ccctcgctgg tgatctgcga actgctcggc      480

gtcccctatt cggaccacga gttcttccag tcctgcagtt ccaggatgct cagccgggag      540

gtcaccgccg aagaacggat gaccgcgttc gagcagctcg aaaactatct cgacgaactg      600

gtcaccaaga aggaggcgaa cgccaccgag gacgacctcc tcggccgtca gatcctgaaa      660

cagcgggaaa cgggcgaggc cgaccacggt gaactcgtcg ggctggcgtt cctgctgctc      720

atcgccggac acgagaccac ggcgaacatg atctcgctcg gcacggtgac cctgctggag      780

aatcccgatc agctcgcgaa gatcaaggca gaccccggca agaccctcgc cgccatcgag      840

gaactcctgc gggtcttcac gatcgcggaa nnngcgacct cacgcttcgc cacggcggac      900

gtcgagatcg gcggaacgct gatccgcgcg ggggaagggg tgnnnggcct gagcaacgcg      960

ggcaaccacg atccggacgg cttcgagaac ccggacacct tcgacatcga acgcggcgcg     1020

cggcatcacg tcgcgttcgg attcggggtg caccagtgtc tcggccagaa cttggcgagg     1080

ttggaactcc agatcgtctt cgatacgttg ttccggcgag tgccgggcct ccggatcgcc     1140

gttccggtcg acgaactgcc gttcaagcac gattcgacga tctacggcct ccacgccctt     1200

ccggtcacct ggtaggagga gccatgaaga tcatcgcgga caccgggaaa tgcgtgggcg     1260

cgggccagtg cgtgctcacc gatcccgatc tgttcgatca gagcgaggac gacggaacgg     1320

tcctcgtgct gaacgccgag cctgaaggcg aagaggcgga agaaaacgcc cgcaccgccg     1380

tgcacatctg cccggggcag gccttgtcgc tcgcttaa                             1418


<210>  110
<211>  404
<212>  PRT
<213>  Amycolatopsis lurida


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (291)..(291)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  Xaa can be any naturally occurring amino acid

<400>  110

Met Thr Asp Val Glu Glu Thr Thr Ala Thr Leu Pro Leu Ala Arg Lys 
1               5                   10                  15      


Cys Pro Phe Ser Pro Pro Pro Glu Tyr Glu Arg Leu Arg Arg Glu Ser 
            20                  25                  30          


Pro Val Ser Arg Val Gly Leu Pro Ser Gly Gln Thr Ala Trp Xaa Leu 
        35                  40                  45              


Thr Arg Leu Glu Asp Ile Arg Glu Met Leu Ser Ser Pro His Phe Ser 
    50                  55                  60                  


Ser Asp Arg Gln Ser Pro Ser Phe Pro Leu Xaa Val Ala Arg Gln Ile 
65                  70                  75                  80  


Arg Arg Glu Asp Lys Pro Phe Arg Pro Ser Leu Ile Ala Met Asp Pro 
                85                  90                  95      


Pro Glu His Ser Arg Ala Arg Arg Asp Val Val Gly Glu Phe Thr Val 
            100                 105                 110         


Lys Arg Met Lys Ala Leu Gln Pro Arg Ile Gln Gln Ile Val Asp Glu 
        115                 120                 125             


His Leu Asp Ala Leu Leu Ala Gly Pro Lys Pro Ala Asp Leu Val Gln 
    130                 135                 140                 


Ala Leu Ser Leu Pro Val Pro Ser Leu Val Ile Cys Glu Leu Leu Gly 
145                 150                 155                 160 


Val Pro Tyr Ser Asp His Glu Phe Phe Gln Ser Cys Ser Ser Arg Met 
                165                 170                 175     


Leu Ser Arg Glu Val Thr Ala Glu Glu Arg Met Thr Ala Phe Glu Gln 
            180                 185                 190         


Leu Glu Asn Tyr Leu Asp Glu Leu Val Thr Lys Lys Glu Ala Asn Ala 
        195                 200                 205             


Thr Glu Asp Asp Leu Leu Gly Arg Gln Ile Leu Lys Gln Arg Glu Thr 
    210                 215                 220                 


Gly Glu Ala Asp His Gly Glu Leu Val Gly Leu Ala Phe Leu Leu Leu 
225                 230                 235                 240 


Ile Ala Gly His Glu Thr Thr Ala Asn Met Ile Ser Leu Gly Thr Val 
                245                 250                 255     


Thr Leu Leu Glu Asn Pro Asp Gln Leu Ala Lys Ile Lys Ala Asp Pro 
            260                 265                 270         


Gly Lys Thr Leu Ala Ala Ile Glu Glu Leu Leu Arg Val Phe Thr Ile 
        275                 280                 285             


Ala Glu Xaa Ala Thr Ser Arg Phe Ala Thr Ala Asp Val Glu Ile Gly 
    290                 295                 300                 


Gly Thr Leu Ile Arg Ala Gly Glu Gly Val Xaa Gly Leu Ser Asn Ala 
305                 310                 315                 320 


Gly Asn His Asp Pro Asp Gly Phe Glu Asn Pro Asp Thr Phe Asp Ile 
                325                 330                 335     


Glu Arg Gly Ala Arg His His Val Ala Phe Gly Phe Gly Val His Gln 
            340                 345                 350         


Cys Leu Gly Gln Asn Leu Ala Arg Leu Glu Leu Gln Ile Val Phe Asp 
        355                 360                 365             


Thr Leu Phe Arg Arg Val Pro Gly Leu Arg Ile Ala Val Pro Val Asp 
    370                 375                 380                 


Glu Leu Pro Phe Lys His Asp Ser Thr Ile Tyr Gly Leu His Ala Leu 
385                 390                 395                 400 


Pro Val Thr Trp 
                


