                         SEQUENCE LISTING

<110>  UMC Utrecht Holding B.V.
       Gadeta B.V.
 
<120>  COMPOSITIONS AND METHODS FOR CELL TARGETING THERAPIES

<130>  P6076171PCT1

<150>  PCT/EP2018/063210
<151>  2018-05-18

<150>  EP18205587.1
<151>  2018-11-12

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic 
       peptide"/note="See specification as filed for detailed 
       description of substitutions and preferred embodiments"

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic 
       oligonucleotide"

<400>  2
gaactatgtg gcagatatcg                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic 
       oligonucleotide"

<400>  3
gtggtgggcg acggcgcgtg                                                   20


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic 
       oligonucleotide"

<400>  4
gaaagaagct ggtgatcgt                                                    19


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic 
       oligonucleotide"

<400>  5
gtgaaccgca tcgagctgaa                                                   20


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic 6xHis tag"

<400>  6

His His His His His His 
1               5       


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  7
cgccatatga tggccgccat ccg                                               23


<210>  8
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  8
cgcctcgagt tagcagcagt tgatgcagc                                         29


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  9

Cys Lys Val Leu 
1               


<210>  10
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  10
gcgccatggg gcaacagcag gaggaaaaa                                         29


<210>  11
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  11
cgctcgaggg gcccctggaa cagaacttcc agaccaccag acgctggaca aatagtc          57


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  12
ttcaccagac aagcgaca                                                     18


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  13
tctcttctgg gcaggagtc                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  14
tccttggggc tctgtgtgt                                                    19


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  15
ggggaaacat ctgcatca                                                     18


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  16
cccagctctt tcacctccca cagggcgcag                                        30


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  17
ccagctcttg cacctcccac agggcgcag                                         29


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  18
cccaggcctt caacctccca cagggcgcag                                        30


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  19
agctcgccgg cctcccacag ggcgcag                                           27


<210>  20
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  20
cagctcttgc cgcacctccc acagggcgca g                                      31


<210>  21
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  21
cagctcccgc acctcccaca gggcgcag                                          28


<210>  22
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  22
ccagttccac ttgagcctcc cacagggcgc ag                                     32


<210>  23
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  23
cagcttcttg tagtatctca cctcccacag ggcgcag                                37


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  24
cccaggccca cctcccacag ggcgcag                                           27


<210>  25
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  25
cagctcgcca gacacctccc acagggcgca g                                      31


<210>  26
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  26
cccagctccc tcttcacctc ccacagggcg cag                                    33


<210>  27
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  27
gggaggtgaa agagctgggc aagaaaatca aggtgttcg                              39


<210>  28
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  28
gggaggtgca agagctgggc aagaaaatca aggtgttcg                              39


<210>  29
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  29
ggaggttgaa ggcctgggca agaaaatcaa ggtgttcg                               38


<210>  30
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  30
gaggccggcg agctgggcaa gaaaatcaag gtgttcg                                37


<210>  31
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  31
gaggtgcggc aagagctggg caagaaaatc aaggtgttcg                             40


<210>  32
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  32
ggaggtgcgg gagctgggca agaaaatcaa ggtgttcg                               38


<210>  33
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  33
gggaggctca agtggaactg ggcaagaaaa tcaaggtgtt cg                          42


<210>  34
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  34
gggaggtgag atactacaag aagctgttcg gcagc                                  35


<210>  35
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  35
ggaggtgggc ctgggcaaga aaatcaaggt gttcg                                  35


<210>  36
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  36
ggaggtgtct ggcgagctgg gcaagaaaat caaggtgttc g                           41


<210>  37
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  37
gaggtgaaga gggagctggg caagaaaatc aaggtgttcg                             40


<210>  38
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  38
gctgtcgccc agaagcagca gtgtgtcgca ggcgcagtag tag                         43


<210>  39
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  39
gtagccgcca ggttcagctg tgtcgcaggc gcagtagtag                             40


<210>  40
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  40
tgtgtggccc caggcgtcgc aggcgcagta gtag                                   34


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  41
gctgcctgta tcgcccaggg cgtcgcaggc                                        30


<210>  42
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  42
gtacagcgcc cccagtgtgt cgcaggcgca gtagtag                                37


<210>  43
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  43
ggggtcgccc agctggtcgc aggcgcagta gtag                                   34


<210>  44
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  44
tatgccccaa tcgggatcgc tgtcgcaggc gcagtagtag                             40


<210>  45
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  45
agtgtcctga gcagcgggaa taccccacgg agtgtcgcag gcgcagtagt ag               52


<210>  46
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  46
agtagttccc caggctagaa accttgggtc gcaggcgcag tagtag                      46


<210>  47
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  47
cggtatcgtg gatagaaggt acagggtcgc aggcgcagta gtag                        44


<210>  48
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  48
agggccaccc gcttggtcgc aggcgcagta gtag                                   34


<210>  49
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  49
ctggtagccg ccagacactg tgtcgcaggc gcagtagtag                             40


<210>  50
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  50
cttgtctgta tctcccagag ctaatgtgtc gcaggcgcag tagtag                      46


<210>  51
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  51
gaggtatcgc caggggcaag aaggtcgcag gcgcagtagt ag                          42


<210>  52
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  52
atctctgtaa ccacctgtgc caagcaccac tgtgtcgcag gcgcagtagt ag               52


<210>  53
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  53
ccaagaacta gcatcaccca tgtcgcaggc gcagtagtag                             40


<210>  54
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  54
ctgcttctgg gcgacagcag cgacaagctg atcttcggca agg                         43


<210>  55
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  55
gctgaacctg gcggctacaa ggacaagctg atcttcggca agg                         43


<210>  56
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  56
gcctggggcc acacagacaa gctgatcttc ggcaagg                                37


<210>  57
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  57
ctgggcgata caggcagcga caagctgatc ttcggcaagg                             40


<210>  58
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  58
cactgggggc gctgtacacc gacaagctga tcttcgg                                37


<210>  59
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  59
cagctgggcg accccgacaa gctgatcttc ggcaagg                                37


<210>  60
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  60
gcgatcccga ttggggcata ctgaacacgg acaagctgat cttcggcaag g                51


<210>  61
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  61
actccgtggg gtattcccgc tgctcaggac actgacaagc tgatcttcgg caagg            55


<210>  62
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  62
ccaaggtttc tagcctgggg aactactgac aagctgatct tcggcaagg                   49


<210>  63
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  63
cctgtacctt ctatccacga taccgacaag ctgatcttcg gc                          42


<210>  64
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  64
caagcgggtg gccctgacaa gctgatcttc ggcaagg                                37


<210>  65
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  65
gtgtctggcg gctaccagta cactgacaag ctgatcttcg gcaagg                      46


<210>  66
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  66
acattagctc tgggagatac agacaagctg atcttcggca agg                         43


<210>  67
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  67
gcccctggcg atacctcttt caccgacaag ctgatcttcg gc                          42


<210>  68
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  68
cttggcacag gtggttacag agatgacaag ctgatcttcg gcaagg                      46


<210>  69
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  69
cgacatgggt gatgctagtt cttgggacac tcgccaaatg                             40


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  70
ctgccatgga gcggatcagc                                                   20


<210>  71
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  71
gccatggtgt ccctgctg                                                     18


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  72
atgcggatcc tcacagg                                                      17


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  73
tagtggatcc tcagctcttc tc                                                22


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  74

Cys Ala Leu Trp Glu Val Lys Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  75

Cys Ala Leu Trp Glu Val Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  76

Cys Ala Leu Trp Glu Val Glu Gly Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  77

Cys Ala Leu Trp Glu Ala Gly Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  78

Cys Ala Leu Trp Glu Val Arg Gln Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15      


Phe 
    


<210>  79
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  79

Cys Ala Leu Trp Glu Val Arg Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  80

Cys Ala Leu Trp Glu Ala Gln Val Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15      


Phe 
    


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  81

Cys Ala Leu Trp Glu Val Arg Tyr Tyr Lys Lys Leu Phe 
1               5                   10              


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  82

Cys Ala Leu Trp Glu Val Gly Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15  


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  83

Cys Ala Leu Trp Glu Val Ser Gly Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15      


Phe 
    


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  84

Cys Ala Leu Trp Glu Val Lys Arg Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15      


Phe 
    


<210>  85
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  85

Cys Ala Leu Trp Glu Val Ile Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  86
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  86

Cys Ala Cys Asp Thr Leu Leu Leu Leu Gly Asp Ser Ser Asp Lys Leu 
1               5                   10                  15      


Ile Phe 
        


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  87

Cys Ala Cys Asp Thr Ala Glu Pro Gly Gly Tyr Lys Asp Lys Leu Ile 
1               5                   10                  15      


Phe 
    


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  88

Cys Ala Cys Asp Ala Trp Gly His Thr Asp Lys Leu Ile Phe 
1               5                   10                  


<210>  89
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  89

Cys Ala Cys Asp Ala Leu Gly Asp Thr Gly Ser Asp Lys Leu Ile Phe 
1               5                   10                  15      


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  90

Cys Ala Cys Asp Thr Leu Gly Ala Leu Tyr Thr Asp Lys Leu Ile Phe 
1               5                   10                  15      


<210>  91
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  91

Cys Ala Cys Asp Gln Leu Gly Asp Pro Asp Lys Leu Ile Phe 
1               5                   10                  


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic polypeptide"

<400>  92

Cys Ala Cys Asp Ser Asp Pro Asp Trp Gly Ile Leu Asn Thr Asp Lys 
1               5                   10                  15      


Leu Ile Phe Cys Ala Cys Asp Thr Val Gly His Gln Gly Lys Leu Ile 
            20                  25                  30          


Phe 
    


<210>  93
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  93

Cys Ala Cys Asp Thr Pro Trp Gly Ile Pro Ala Ala Gln Asp Thr Asp 
1               5                   10                  15      


Lys Leu Ile Phe 
            20  


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  94

Cys Ala Cys Asp Pro Arg Phe Leu Ala Trp Gly Thr Thr Asp Lys Leu 
1               5                   10                  15      


Ile Phe 
        


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  95

Cys Ala Cys Asp Pro Val Pro Ser Ile His Asp Thr Asp Lys Leu Ile 
1               5                   10                  15      


Phe 
    


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  96

Cys Ala Cys Asp Gln Ala Gly Gly Pro Asp Lys Leu Ile Phe 
1               5                   10                  


<210>  97
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  97

Cys Ala Cys Asp Thr Val Ser Gly Gly Tyr Gln Tyr Thr Asp Lys Leu 
1               5                   10                  15      


Ile Phe 
        


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  98

Cys Ala Cys Asp Thr Leu Ala Leu Gly Asp Thr Asp Lys Leu Ile Phe 
1               5                   10                  15      


<210>  99
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  99

Cys Ala Cys Asp Leu Leu Ala Pro Gly Asp Thr Ser Phe Thr Asp Lys 
1               5                   10                  15      


Leu Ile Phe 
            


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  100

Cys Ala Cys Asp Thr Val Val Leu Gly Thr Gly Gly Tyr Arg Asp Asp 
1               5                   10                  15      


Lys Leu Ile Phe 
            20  


<210>  101
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  101

Cys Ala Cys Asp Met Gly Asp Ala Ser Ser Trp Asp Thr Arg Gln Met 
1               5                   10                  15      


Phe Phe 
        


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  102

Cys Ala Cys Val Pro Leu Leu Ala Asp Thr Asp Lys Leu Ile Phe 
1               5                   10                  15  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  103

Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15      


Phe 
    


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  104

Cys Ala Leu Trp Glu Glu Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15  


<210>  105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  105

Cys Ala Leu Trp Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  106
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  106

Cys Ala Cys Asp Thr Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu 
1               5                   10                  15      


Ile Phe 
        


<210>  107
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  107

Cys Ala Cys Asp Leu Leu Gly Tyr Thr Asp Lys Leu Ile Phe 
1               5                   10                  


<210>  108
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic peptide"

<400>  108

Cys Ala Cys Asp Ala Leu Lys Arg Thr Asp Thr Asp Lys Leu Ile Phe 
1               5                   10                  15      


<210>  109
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  109

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      


Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          


Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              


Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  


Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys Lys Ile Lys Val 
            100                 105                 110         


Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu Asp Ala 
        115                 120                 125             


Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr 
    130                 135                 140                 


Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe 
145                 150                 155                 160 


Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn Thr Ile 
                165                 170                 175     


Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met 
            180                 185                 190         


Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His 
        195                 200                 205             


Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu 
    210                 215                 220                 


Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys 
225                 230                 235                 240 


Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr 
                245                 250                 255     


Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val 
            260                 265                 270         


Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe 
        275                 280                 285             


Cys Cys Asn Gly Glu Lys Ser 
    290                 295 


<210>  110
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      


Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          


Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Met Thr Phe 
        35                  40                  45              


Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  


Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  


Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Thr 
                85                  90                  95      


Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly 
            100                 105                 110         


Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser 
        115                 120                 125             


Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu 
    130                 135                 140                 


Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile 
145                 150                 155                 160 


Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn 
                165                 170                 175     


Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser 
            180                 185                 190         


Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys 
        195                 200                 205             


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
    210                 215                 220                 


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
225                 230                 235                 240 


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
                245                 250                 255     


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
            260                 265                 270         


Leu 
    


<210>  111
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  111

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      


Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          


Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              


Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  


Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Trp Glu Glu Glu Leu Gly Lys Lys Ile Lys Val Phe Gly 
            100                 105                 110         


Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu Asp Ala Asp Val 
        115                 120                 125             


Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu 
    130                 135                 140                 


Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp 
145                 150                 155                 160 


Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn Thr Ile Leu Gly 
                165                 170                 175     


Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe 
            180                 185                 190         


Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys 
        195                 200                 205             


Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile 
    210                 215                 220                 


Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn 
225                 230                 235                 240 


Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr 
                245                 250                 255     


Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr 
            260                 265                 270         


Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys 
        275                 280                 285             


Asn Gly Glu Lys Ser 
    290             


<210>  112
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  112

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      


Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          


Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Met Thr Phe 
        35                  40                  45              


Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  


Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  


Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Leu 
                85                  90                  95      


Leu Gly Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr 
            100                 105                 110         


Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met 
        115                 120                 125             


Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys 
    130                 135                 140                 


Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp 
145                 150                 155                 160 


Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu 
                165                 170                 175     


Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp 
            180                 185                 190         


Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr 
        195                 200                 205             


Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys 
    210                 215                 220                 


Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
225                 230                 235                 240 


Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val 
                245                 250                 255     


Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu 
            260                 265                 


<210>  113
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  113

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      


Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          


Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              


Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  


Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Trp Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
            100                 105                 110         


Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu Asp Ala Asp 
        115                 120                 125             


Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys 
    130                 135                 140                 


Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro 
145                 150                 155                 160 


Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn Thr Ile Leu 
                165                 170                 175     


Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys 
            180                 185                 190         


Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg 
        195                 200                 205             


Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile 
    210                 215                 220                 


Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp 
225                 230                 235                 240 


Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn 
                245                 250                 255     


Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val 
            260                 265                 270         


Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys 
        275                 280                 285             


Cys Asn Gly Glu Lys Ser 
    290                 


<210>  114
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  114

Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly 
1               5                   10                  15      


Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn 
            20                  25                  30          


Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Met Thr Phe 
        35                  40                  45              


Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe 
    50                  55                  60                  


Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu 
65                  70                  75                  80  


Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Ala 
                85                  90                  95      


Leu Lys Arg Thr Asp Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg 
            100                 105                 110         


Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser Val Phe 
        115                 120                 125             


Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu 
145                 150                 155                 160 


Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val 
                165                 170                 175     


Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val Gln 
            180                 185                 190         


His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr Asp 
        195                 200                 205             


Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro 
    210                 215                 220                 


Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val 
225                 230                 235                 240 


Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys 
                245                 250                 255     


Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu 
            260                 265                 270     


<210>  115
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys 
        115                 120                 125             


Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys 
    130                 135                 140                 


Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
145                 150                 155                 160 


Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu 
                165                 170                 175     


Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys 
            180                 185                 190         


Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn 
        195                 200                 205             


Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu 
    210                 215                 220                 


Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly 
225                 230                 235                 240 


Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr 
                245                 250                 255     


Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu 
            260                 265                 270         


Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu 
        275                 280                 285             


Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg 
    290                 295                 300                 


Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
305                 310                 315 


<210>  116
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly 
1               5                   10                  15      


Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
            20                  25                  30          


Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
        35                  40                  45              


Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
    50                  55                  60                  


Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
65                  70                  75                  80  


Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
                85                  90                  95      


Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
            100                 105                 110         


Cys Asp Thr Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu Ile Phe 
        115                 120                 125             


Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr 
    130                 135                 140                 


Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu 
145                 150                 155                 160 


Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser 
                165                 170                 175     


Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly 
            180                 185                 190         


Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val 
        195                 200                 205             


Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe 
    210                 215                 220                 


Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu 
225                 230                 235                 240 


Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val 
                245                 250                 255     


His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg 
            260                 265                 270         


Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys 
        275                 280                 285             


Leu Phe Phe Leu 
    290         


<210>  117
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Glu Glu Leu Gly Lys Lys Ile 
        115                 120                 125             


Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu 
    130                 135                 140                 


Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala 
145                 150                 155                 160 


Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys 
                165                 170                 175     


Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn 
            180                 185                 190         


Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr 
        195                 200                 205             


Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys 
    210                 215                 220                 


Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp 
225                 230                 235                 240 


Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
                245                 250                 255     


Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln 
            260                 265                 270         


Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys 
        275                 280                 285             


Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr 
    290                 295                 300                 


Ala Phe Cys Cys Asn Gly Glu Lys Ser 
305                 310             


<210>  118
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly 
1               5                   10                  15      


Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
            20                  25                  30          


Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
        35                  40                  45              


Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
    50                  55                  60                  


Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
65                  70                  75                  80  


Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
                85                  90                  95      


Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
            100                 105                 110         


Cys Asp Leu Leu Gly Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr 
        115                 120                 125             


Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser Val 
    130                 135                 140                 


Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr 
                165                 170                 175     


Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala 
            180                 185                 190         


Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val 
        195                 200                 205             


Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr 
    210                 215                 220                 


Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln 
225                 230                 235                 240 


Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys 
                245                 250                 255     


Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala 
            260                 265                 270         


Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu 
        275                 280                 285             


<210>  119
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ile Gln Glu Leu Gly Lys Lys 
        115                 120                 125             


Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln 
    130                 135                 140                 


Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile 
145                 150                 155                 160 


Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu 
                165                 170                 175     


Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser 
            180                 185                 190         


Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp 
        195                 200                 205             


Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp 
    210                 215                 220                 


Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val 
225                 230                 235                 240 


Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met 
                245                 250                 255     


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
            260                 265                 270         


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
        275                 280                 285             


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg 
    290                 295                 300                 


Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
305                 310                 


<210>  120
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly 
1               5                   10                  15      


Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
            20                  25                  30          


Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
        35                  40                  45              


Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
    50                  55                  60                  


Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
65                  70                  75                  80  


Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
                85                  90                  95      


Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
            100                 105                 110         


Cys Asp Ala Leu Lys Arg Thr Asp Thr Asp Lys Leu Ile Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro 
    130                 135                 140                 


Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys 
145                 150                 155                 160 


Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys 
                165                 170                 175     


Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr 
            180                 185                 190         


Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys 
        195                 200                 205             


Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val 
    210                 215                 220                 


Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr 
225                 230                 235                 240 


Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr 
                245                 250                 255     


Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu 
            260                 265                 270         


Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe 
        275                 280                 285             


Phe Leu 
    290 


