                         SEQUENCE LISTING

<110>  NATIONAL RESEARCH COUNCIL OF CANADA
 
<120>  ANTIBODIES AND ANTIBODY FRAGMENTS AGAINST HNAV1.7 CHANNEL AND 
       THEIR USE IN PAIN AND CANCER INDICATIONS

<130>  05002139-48PCT

<150>  US 62/673210
<151>  2018-05-18

<160>  132   

<170>  PatentIn version 3.5

<210>  1
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIE3IR = 70 amino acid sequence located on loop3 of the D1 domain
       of the Nav1.7 polypeptide

<400>  1

Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu 
1               5                   10                  15      


Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe 
            20                  25                  30          


Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr 
        35                  40                  45              


Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg 
    50                  55                  60                  


Asn Pro Asp Tyr Gly Tyr 
65                  70  


<210>  2
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric FC5DIE3IR protein with signal peptide

<400>  2

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile 
        35                  40                  45              


Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser 
65                  70                  75                  80  


Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Ser Thr Lys His Lys Cys Phe Arg Asn Ser 
        115                 120                 125             


Leu Glu Asn Asn Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser 
    130                 135                 140                 


Glu Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp 
145                 150                 155                 160 


Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly 
                165                 170                 175     


Tyr Thr Cys Val Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Arg Val 
            180                 185                 190         


Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        195                 200                 205 


<210>  3
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric FC5DIE3IR protein without signal peptide

<400>  3

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn 
            100                 105                 110         


Asn Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp 
        115                 120                 125             


Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu 
    130                 135                 140                 


Cys Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys 
145                 150                 155                 160 


Val Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Arg Val Asp Tyr Trp 
                165                 170                 175     


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
            180                 185     


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #1 = 30 amino acid sequence located on loop3 of the D1 
       domain of the Nav1.7 polypeptide

<400>  4

Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu 
1               5                   10                  15      


Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #2 = 30 amino acid sequence located on loop3 of the D1 
       domain of the Nav1.7 polypeptide

<400>  5

Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu 
1               5                   10                  15      


Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #3 = 30 amino acid sequence located on loop3 of the D1 
       domain of the Nav1.7 polypeptide

<400>  6

Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly 
1               5                   10                  15      


Tyr Thr Cys Val Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr 
            20                  25                  30  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of the 3A8 antibody

<400>  7

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of the 3A8 antibody

<400>  8

Ile Asn Pro Ser Asn Gly Arg Ala 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of the 3A8 antibody

<400>  9

Ala Arg Ser Pro Tyr Gly Tyr Tyr Asp Tyr 
1               5                   10  


<210>  10
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the heavy chain of the 3A8 antibody

<400>  10

Thr Thr Thr Thr Thr Gly Gly Thr Ala Gly Cys Ala Ala Cys Ala Gly 
1               5                   10                  15      


Cys Thr Ala Cys Ala Gly Ala Thr Gly Thr Cys Cys Ala Cys Thr Cys 
            20                  25                  30          


Cys Cys Ala Gly Gly Thr Cys Cys Ala Ala Cys Thr Gly Cys Ala Gly 
        35                  40                  45              


Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Ala Cys 
    50                  55                  60                  


Thr Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys 
65                  70                  75                  80  


Thr Thr Cys Ala Gly Thr Gly Ala Ala Gly Cys Thr Gly Thr Cys Cys 
                85                  90                  95      


Thr Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr 
            100                 105                 110         


Ala Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Ala Cys Thr Ala 
        115                 120                 125             


Cys Thr Gly Gly Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ala Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Ala Cys 
145                 150                 155                 160 


Ala Ala Gly Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr 
                165                 170                 175     


Thr Gly Gly Ala Gly Ala Gly Ala Thr Thr Ala Ala Thr Cys Cys Thr 
            180                 185                 190         


Ala Gly Cys Ala Ala Cys Gly Gly Thr Cys Gly Thr Gly Cys Thr Ala 
        195                 200                 205             


Ala Cys Thr Ala Cys Ala Ala Thr Gly Ala Gly Ala Ala Gly Thr Thr 
    210                 215                 220                 


Cys Ala Ala Gly Ala Gly Cys Ala Ala Gly Gly Cys Cys Ala Cys Ala 
225                 230                 235                 240 


Cys Thr Gly Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Ala Ala Thr 
                245                 250                 255     


Cys Cys Thr Cys Cys Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr Ala 
            260                 265                 270         


Cys Ala Thr Gly Cys Ala Ala Cys Thr Cys Ala Gly Cys Ala Gly Cys 
        275                 280                 285             


Cys Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Thr 
    290                 295                 300                 


Cys Thr Gly Cys Gly Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Ala Gly Ala Thr Cys Cys Cys Cys Thr Thr Ala Thr 
                325                 330                 335     


Gly Gly Thr Thr Ala Cys Thr Ala Cys Gly Ala Cys Thr Ala Cys Thr 
            340                 345                 350         


Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Cys Ala Cys Cys Ala Cys 
        355                 360                 365             


Thr Cys Thr Cys Ala Cys Ala Gly Thr Cys Thr Cys Cys Thr Cys Ala 
    370                 375                 380                 


Gly Cys Cys Ala Ala Ala Ala Cys Ala Ala Cys Ala Gly Cys Cys Cys 
385                 390                 395                 400 


Cys Ala Thr Cys Gly Gly Thr Cys Thr Ala Thr Cys Cys Cys Cys Thr 
                405                 410                 415     


Gly Gly Cys Cys Cys Cys Thr 
            420             


<210>  11
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 3A8 antibody with leader sequence

<400>  11

Phe Leu Val Ala Thr Ala Thr Asp Val His Ser Gln Val Gln Leu Gln 
1               5                   10                  15      


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
            20                  25                  30          


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Trp Met His Trp Val 
        35                  40                  45              


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro 
    50                  55                  60                  


Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr 
65                  70                  75                  80  


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                85                  90                  95      


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Pro Tyr 
            100                 105                 110         


Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 125             


Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140     


<210>  12
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 3A8 antibody without leader sequence

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Tyr Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro 
    130 


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1 of the 3A8 antibody

<400>  13

Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2 of the 3A8 antibody

<400>  14

Lys Val Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3 of the 3A8 antibody

<400>  15

Ser Gln Ile Thr His Val Pro Leu Thr 
1               5                   


<210>  16
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the 3A8 antibody

<400>  16
ctgatgaagt tgcctgttag gctgttggtg ctgatgttct ggattcctgc ttccagcagt       60

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      120

atctcttgca gatctagtca gagcctttta cacagtaatg gaaacaccta tttccattgg      180

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      240

tttggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      300

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaattac acatgttccg      360

ctcacgttcg gtgctgggac caagctggag ctgaaacggg ctgatgctgc accaactgta      420

tccatcttcc caccatccag t                                                441


<210>  17
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 3A8 antibody with leader sequence

<400>  17

Leu Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro 
1               5                   10                  15      


Ala Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Phe Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
            100                 105                 110         


Cys Ser Gln Ile Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser 
145         


<210>  18
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 3A8 antibody without leader sequence

<400>  18

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ile 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125         


<210>  19
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the heavy chain of the 1G5 and 1G9 
       antibodies

<400>  19
tttttggtag ctgcagctac aggtgtccac tcccaggtcc aactgcagca gcctggggct       60

gagcttgtga agcctggggc ttcagtgaag ctgtcctgca aggcttctgg ctacactttc      120

accagctact ggataaactg ggtgaagcag aggcctggac aaggccttga gtggattgga      180

aatatttatc ctggtaatag taatactaac tacaatgaga agttcaagag caaggccaca      240

ctgactgtag acaaatcctc cagcacagcc tacatgcagc tcagcagcct gacatctgag      300

gactctgcgg tctattattg tgcaagacgg tactactatg attacgacga tgctatggac      360

tactggggtc aaggaacctc agtcaccgtc tcctcagcca aaacgacacc cccatctgtc      420

tatcccctgg cccct                                                       435


<210>  20
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 1G5 and 1G9 antibodies with leader sequence

<400>  20

Phe Leu Val Ala Ala Ala Thr Gly Val His Ser Gln Val Gln Leu Gln 
1               5                   10                  15      


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
            20                  25                  30          


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn Trp Val 
        35                  40                  45              


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asn Ile Tyr Pro 
    50                  55                  60                  


Gly Asn Ser Asn Thr Asn Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr 
65                  70                  75                  80  


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                85                  90                  95      


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Tyr Tyr 
            100                 105                 110         


Tyr Asp Tyr Asp Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
        115                 120                 125             


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
    130                 135                 140                 


Pro 
145 


<210>  21
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 1G5 and 1G9 antibodies without leader sequence

<400>  21

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Asn Ser Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Tyr Asp Tyr Asp Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro 
    130                 


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of the 1G5 and 1G9 antibodies

<400>  22

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of the 1G5 and the 1G9 antibodies

<400>  23

Ile Tyr Pro Gly Asn Ser Asn Thr 
1               5               


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of the 1G5 and 1G9 antibodies

<400>  24

Ala Arg Arg Tyr Tyr Tyr Asp Tyr Asp Asp Ala Met Asp Tyr 
1               5                   10                  


<210>  25
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the 1G5 and 1G9 
       antibodies

<400>  25
cttatgttgc tgctgctatg ggttccaggt tccacaggtg acattgtgct gacccaatct       60

ccagcttctt tggctgtgtc tctagggcag agggccacca tatcctgcag agccagtgaa      120

agtgttgata gttatggcaa tggttttatg cactggtacc agcagaaacc aggacagcca      180

cccaaactcc tcatctatcg tgcatccaac ctagaatctg ggatccctgc cagggtcagt      240

ggcagtgggt ctaggacaga cttcaccctc accattaatc ctgtggaggc tgatgatgtt      300

gcaacctatt actgtcagca aagtaatgag gatccgtgga cgttcggtgg aggcaccaag      360

ctggaaatca aacgggctga tgctgcacca actgtatcca tcttcccacc atccagt         417


<210>  26
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 1G5 and the 1G9 antibodies with leader 
       sequence

<400>  26

Leu Met Leu Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Val 
1               5                   10                  15      


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
            20                  25                  30          


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Gly 
        35                  40                  45              


Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
    50                  55                  60                  


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Val Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
                85                  90                  95      


Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
            100                 105                 110         


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
        115                 120                 125             


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135                 


<210>  27
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 1G5 and 1G9 antibodies without leader sequence

<400>  27

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Val Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125     


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1 of the 1G5 and the 1G9 antibodies

<400>  28

Glu Ser Val Asp Ser Tyr Gly Asn Gly Phe 
1               5                   10  


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2 of the 1G5 and 1G9 antibodies

<400>  29

Arg Ala Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3 of the 1G5 antibodies

<400>  30

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  31
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-A

<400>  31
caggctcagg tacagctggt ggagtctggg ggaggattgg tgcagcctgg gggctctctg       60

agactctcct gtgcagcctc tggacgcacc atcagtagct ttaccatggg ctggttccgc      120

caggctccag gggcggagcg tgagtttgta gcagctatta gtcggagtgg tagtagtaca      180

gtctatgcag gctccgtgaa gggccgattc accatctcca gagacaacgc caagaacacg      240

gtgtatctgc aaatgaacag cctgaaacct gaggacacgg ccgtctatta ctgtaatgca      300

gttattaccg aacccctcta caaaacggac gatagttact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  32
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-A

<400>  32

Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser 
            20                  25                  30          


Ser Phe Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Ser Ser Thr Val Tyr Ala Gly 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Ala Val Ile Thr Glu Pro Leu Tyr Lys Thr Asp Asp Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  33
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-B

<400>  33
caggtaaagc tggaggagtc tgggggaggc ttggtgccgc ctggggagtc tctgaggctc       60

acctgtgcgg ccactggaca aaccgctagt gtatatgaaa tggcctggtt ccgccgcgct      120

ccagagaagg agcaagtata tgtggcatct attaactggc gggatggtga cacacaatat      180

cataactccg tgaagggccg attcatcatc tctagagaca atgccaagaa cacggtattt      240

ctccaaatga acagtttaac acctgaggac acggccatct attactgcgc agcgcgaaaa      300

gaattggcgg ggtatgacta ctggggccaa gggacccagg tcaccgtctc ctca            354


<210>  34
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-B

<400>  34

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Thr Gly Gln Thr Ala Ser Val Tyr 
            20                  25                  30          


Glu Met Ala Trp Phe Arg Arg Ala Pro Glu Lys Glu Gln Val Tyr Val 
        35                  40                  45              


Ala Ser Ile Asn Trp Arg Asp Gly Asp Thr Gln Tyr His Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Lys Glu Leu Ala Gly Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  35
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-C

<400>  35

Cys Ala Gly Gly Thr Ala Ala Ala Gly Cys Thr Gly Gly Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr 
            20                  25                  30          


Gly Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Ala Gly 
        35                  40                  45              


Thr Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Gly Thr 
    50                  55                  60                  


Gly Thr Gly Thr Ala Gly Gly Thr Thr Cys Thr Gly Gly Ala Thr Thr 
65                  70                  75                  80  


Cys Ala Ala Cys Thr Thr Cys Ala Gly Gly Ala Thr Cys Cys Ala Gly 
                85                  90                  95      


Gly Cys Cys Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Thr Cys Cys 
            100                 105                 110         


Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala 
        115                 120                 125             


Gly Gly Ala Gly Cys Gly Thr Gly Ala Ala Thr Thr Thr Gly Thr Cys 
    130                 135                 140                 


Gly Cys Cys Ala Gly Thr Ala Thr Thr Ala Gly Cys Gly Gly Gly Ala 
145                 150                 155                 160 


Gly Cys Gly Gly Thr Gly Cys Thr Ala Cys Cys Ala Cys Cys Gly Ala 
                165                 170                 175     


Cys Cys Ala Thr Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Gly Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Cys Ala Ala Ala Gly Ala Cys Ala Ala Cys Gly Cys 
    210                 215                 220                 


Cys Ala Gly Gly Gly Ala Cys Ala Cys Ala Ala Thr Gly Thr Ala Thr 
225                 230                 235                 240 


Thr Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Ala Cys Cys 
                245                 250                 255     


Thr Gly Ala Ala Ala Cys Cys Gly Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Cys 
        275                 280                 285             


Thr Ala Thr Gly Cys Ala Ala Thr Thr Ala Gly Thr Cys Ala Ala Cys 
    290                 295                 300                 


Ala Thr Gly Thr Ala Cys Cys Gly Cys Cys Gly Thr Ala Thr Cys Ala 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly 
                325                 330                 335     


Ala Cys Cys Cys Ala Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr 
            340                 345                 350         


Cys Cys Thr Cys Ala 
        355         


<210>  36
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-C

<400>  36

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Asn Phe Arg Ile Gln 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Ser Gly Ala Thr Thr Asp His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Arg Asp Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Ile Ser Gln His Val Pro Pro Tyr His Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-D

<400>  37
caggtaaagc tggaggagtc tggggggggc ttggtacagc ccggggggtc tctgaaactc       60

tcgtgtgtag cctctggatt cgccttcagc tccgctccaa tggactgggt ccgtaaggct      120

ccagggaagg acgttgagtg gctctcaact attgaaagtg accaagacca caccatatat      180

tatgcaaact ccgtgaaggg ccgattcact atttcccgag atgatgtcca gaacatcttg      240

tatctgcaaa tgaacgacct gaaaattgag gacacggcca catattactg tcagaaacgt      300

ggagagaaga aaacccgggg ccaggggacc caggtcaccg tctcctca                   348


<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-D

<400>  38

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Ala Phe Ser Ser Ala 
            20                  25                  30          


Pro Met Asp Trp Val Arg Lys Ala Pro Gly Lys Asp Val Glu Trp Leu 
        35                  40                  45              


Ser Thr Ile Glu Ser Asp Gln Asp His Thr Ile Tyr Tyr Ala Asn Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Val Gln Asn Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asp Leu Lys Ile Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Gln Lys Arg Gly Glu Lys Lys Thr Arg Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of DI-D

<400>  39

Gly Phe Ala Phe Ser Ser Ala Pro 
1               5               


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of DI-D

<400>  40

Ile Glu Ser Asp Gln Asp His Thr Ile 
1               5                   


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of DI-D

<400>  41

Gln Lys Arg Gly Glu Lys Lys Thr 
1               5               


<210>  42
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-E

<400>  42
caggtaaagc tggaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctgaatt caccttcagt agctcctggg ggcattgggt ccgtcaggct      120

ccagggaagg ggctcaagtg ggtctcaagt attaattctg gtggcgaagg cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acggcaagaa cacgctgtat      240

ctggaaatga acagtctgaa atctgaagac acggccgtgt attactgcac atcagcctcc      300

ggggcgtggg gccaggggat ccaggtcacc gtctcctca                             339


<210>  43
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-E

<400>  43

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Trp Gly His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ser Gly Gly Glu Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Ala Ser Gly Ala Trp Gly Gln Gly Ile Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  44
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-H

<400>  44
caggtaaagc tggaggagtc tgggggaggc ttggtgcagg ctggggagtc tctgagactc       60

tcctgtgtaa attctggaag taccttcagt atctatgcca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagcc attagtagtg ttggtaggac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagccggag ccaagaacac agtctatctt      240

catatgaaca accttaaacc cgaggacacg gccgtctatt cgtgtataac gtactaccag      300

aacgcaatgt attttggcca gggcacccag gtcaccgtct cctca                      345


<210>  45
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-H

<400>  45

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asn Ser Gly Ser Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Val Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Ala Gly Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


His Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ile 
                85                  90                  95      


Thr Tyr Tyr Gln Asn Ala Met Tyr Phe Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  46
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-4

<400>  46
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactactgga tgtattgggt ccgacaggct      120

ccagggaagg ggctcgagcg ggtctcatcc atttatatca gtggtggtaa tacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga atagtctgaa atctgaggac acggccgtgt attactgtgt aaaaggggat      300

acttttggcg gcatggacta ttggggcaaa gggacccagg tcaccgtctc ctca            354


<210>  47
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-4

<400>  47

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val 
        35                  40                  45              


Ser Ser Ile Tyr Ile Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Asp Thr Phe Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  48
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence encoding DI-16

<400>  48
caggctcagg tacagctggt ggagtctggg ggaggattgg tgcaggctgg gggctctctg       60

agactctcct gtgcagcctc tggacgcacc gtcagtagct ataccatggg ctggttccgc      120

caggctccag ggaaggagcg tagattcgta gcgactgtta attctagtgg tagaggaact      180

cattatgcag actccgtgaa gggccgattc accatctcca gagacaacgc caagaacacg      240

gtgtatctgc aaatgaacag cctgaaacct gaggacacgg ccgtttatta ctgtgcagca      300

gctccgtatc ccgacggatc gctgggaccg ggatatgact actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  49
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-16

<400>  49

Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser 
            20                  25                  30          


Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Arg 
        35                  40                  45              


Phe Val Ala Thr Val Asn Ser Ser Gly Arg Gly Thr His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Pro Tyr Pro Asp Gly Ser Leu Gly Pro Gly Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of DI-16

<400>  50

Gly Arg Thr Val Ser Ser Tyr Thr 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of DI-16

<400>  51

Val Asn Ser Ser Gly Arg Gly Thr 
1               5               


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of DI-16

<400>  52

Ala Ala Ala Pro Tyr Pro Asp Gly Ser Leu Gly Pro Gly Tyr Asp Tyr 
1               5                   10                  15      


<210>  53
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-28

<400>  53
caggctcagg tacagctggt ggagtctggg ggaggcttgg tgcaggctgg gggctctctg       60

agactctcct gtgcagcctc tggacgcacg ttcagtagtt ctggcatggg ctggttccgc      120

caggctccag ggaaggaccg tgaacttgta gcaggtatta gttggagtgg tgatagcgca      180

tactatgcaa actccgtggc gggccgattc accatctcca gagacaacat caacaacacg      240

gtgtatctgc aaatgaatag cctgaaacct gaggacacgg ccgtttatta ctgtgcagcc      300

cgacaaggtg gtcgtaacta cgcaacaagt ccgcgagaat atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  54
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-28

<400>  54

Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Ser Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu 
        35                  40                  45              


Leu Val Ala Gly Ile Ser Trp Ser Gly Asp Ser Ala Tyr Tyr Ala Asn 
    50                  55                  60                  


Ser Val Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Ile Asn Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Gln Gly Gly Arg Asn Tyr Ala Thr Ser Pro Arg 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of DI-28

<400>  55

Gly Arg Thr Phe Ser Ser Ser Gly 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of DI-28

<400>  56

Ile Ser Trp Ser Gly Asp Ser Ala 
1               5               


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of DI-28

<400>  57

Ala Ala Arg Gln Gly Gly Arg Asn Tyr Ala Thr Ser Pro Arg Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  58
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding DI-48

<400>  58
caggctcagg tacagctggt ggagtctggg ggaggattgg tgcaggctgg gggctctctg       60

agactctcct gtgcagcctc tggacgcacc ttcagtacct atgtcatggg ctggttccgc      120

cagactccag ggaaggagcg tgagtttgta gcaggtttta gttggagtgg cgattacgca      180

atctatgtca actccgtgaa gggccgattc accatctcca gagacaacgc caagaacacg      240

gtgtatctgc aaatgaacag tctgagacct gaggacacgg ccgtttatta ctgcgcagca      300

cgccaacgag ggggctatag tggtagatcc tattacaccg ggcgaaatga ctatgagtac      360

tggggccagg ggacccaggt caccgtctcc tca                                   393


<210>  59
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI-48

<400>  59

Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Tyr Val Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Phe Ser Trp Ser Gly Asp Tyr Ala Ile Tyr Val Asn 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Gln Arg Gly Gly Tyr Ser Gly Arg Ser Tyr Tyr 
            100                 105                 110         


Thr Gly Arg Asn Asp Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  60
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 of the framework of FC5

<400>  60

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 of the framework of FC5

<400>  61

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
1               5                   10                  15      


Arg 
    


<210>  62
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 of the framework of FC5

<400>  62

Phe Tyr Ser Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Asp Tyr Tyr Cys 
        35              


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 of the framework of FC5

<400>  63

Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of FC5

<400>  64

Gly Phe Lys Ile Thr His Tyr Thr 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of FC5

<400>  65

Ile Thr Trp Gly Gly Asp Asn Thr 
1               5               


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of FC5

<400>  66

Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr 
1               5                   10                  15  


<210>  67
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5DIE3IR with signal sequence

<400>  67

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile 
        35                  40                  45              


Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser 
65                  70                  75                  80  


Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Ser Thr Lys His Lys Cys Phe Arg Asn Ser 
        115                 120                 125             


Leu Glu Asn Asn Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser 
    130                 135                 140                 


Glu Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp 
145                 150                 155                 160 


Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly 
                165                 170                 175     


Tyr Thr Cys Val Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Arg Val 
            180                 185                 190         


Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        195                 200                 205 


<210>  68
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5DIE3IR without signal sequence

<400>  68

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn 
            100                 105                 110         


Asn Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp 
        115                 120                 125             


Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu 
    130                 135                 140                 


Cys Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys 
145                 150                 155                 160 


Val Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Arg Val Asp Tyr Trp 
                165                 170                 175     


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
            180                 185     


<210>  69
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence of FC5DIE3IR

<400>  69

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  70
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogen with no epitope with signal sequence


<220>
<221>  VARIANT
<222>  (121)..(121)
<223>  Xaa is the peptide epitope

<400>  70

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile 
        35                  40                  45              


Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser 
65                  70                  75                  80  


Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Ser Thr Xaa Arg Val Asp Tyr Trp Gly Lys 
        115                 120                 125             


Gly Thr Gln Val Thr Val Ser Ser Ala Ser 
    130                 135             


<210>  71
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogen with no epitope without signal sequence


<220>
<221>  VARIANT
<222>  (102)..(102)
<223>  Xaa is the peptide epitope

<400>  71

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Xaa Arg Val Asp Tyr Trp Gly Lys Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser 
        115                 


<210>  72
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys 
    1970                 1975         


<210>  73
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the heavy chain of the 1B6 antibody

<400>  73
tgcctggtga cgttcccaag ctgtgtcctg tcccaggtgc agctgaagga gtcaggacct       60

ggcctggtgg caccctcaca gagcctgtcc atcacatgca ctgtctctgg gttctcatta      120

tccagatata atgtacactg ggttcgccag cctccaggaa agggtctgga gtggctggga      180

atgatatggg gtggtggaag cacagactat aattcagctc tcaaatccag acttagcatc      240

agcaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca aactgatgac      300

acagccatgt actactgtgc cagaaatgga gctaactggg actggtttgc ttactggggc      360

caagggactc tggtcactgt ctctgcagcc aaaacgacac ccccatctgt ctat            414


<210>  74
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 1B6 antibody

<400>  74

Cys Leu Val Thr Phe Pro Ser Cys Val Leu Ser Gln Val Gln Leu Lys 
1               5                   10                  15      


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr 
            20                  25                  30          


Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Asn Val His Trp Val 
        35                  40                  45              


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 
    50                  55                  60                  


Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 
65                  70                  75                  80  


Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
                85                  90                  95      


Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asn Gly Ala Asn 
            100                 105                 110         


Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
    130                 135             


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of the 1B6 antibody

<400>  75

Gly Phe Ser Leu Ser Arg Tyr Asn 
1               5               


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of the 1B6 antibody

<400>  76

Ile Trp Gly Gly Gly Ser Thr 
1               5           


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of the 1B6 antibody

<400>  77

Ala Arg Asn Gly Ala Asn Trp Asp Trp Phe Ala Tyr 
1               5                   10          


<210>  78
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the 1B6 antibody

<400>  78
ctgctatggg tatctggtac ctgtggggac attgtgatgt cacagtctcc atcctcccta       60

cctgtgtcag ttggagagaa ggttactatg agctgcaagt ccagtcagag ccttttatat      120

agtagcaatc aaaagaacta cttggcctgg taccagcaga aaccagggca gtctcctaaa      180

ctgctgattt actgggcatc cactagggaa tctggggtcc ctgatcgctt cacaggcagt      240

ggatctggga cagatttcac tctcaccatc agcagtgtga aggctgaaga cctggcagtt      300

tattactgtc agcaatatta tagctatcca ttcacgttcg gctcggggac aaagttggaa      360

ataaaacggg ctgatgctgc accaactgta tccatcttcc caccatccag tgtc            414


<210>  79
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 1B6 antibody

<400>  79

Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Val Ser Val Gly Glu Lys Val Thr Met Ser Cys 
            20                  25                  30          


Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
        35                  40                  45              


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
    50                  55                  60                  


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu 
                85                  90                  95      


Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
            100                 105                 110         


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
        115                 120                 125             


Thr Val Ser Ile Phe Pro Pro Ser Ser Val 
    130                 135             


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1 of the 1B6 antibody

<400>  80

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  81
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2 of the 1B6 antibody

<400>  81

Trp Ala Ser 
1           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3 of the 1B6 antibody

<400>  82

Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  83
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the heavy chain of the 2G11 antibody

<400>  83
tttttggtag caacagctac agatgtccac tcccaggtcc aactgcagca gcctggggct       60

gaactggtga agcctggggc ttcagtgaag ctgtcctgca aggcttctgg ctacaccttc      120

accacctact ggatgcactg ggtgaagcag aggcctggac aaggccttga gtggattgga      180

gagattaatc ctagcaacgg tcgtgctaac tacaatgaga agttcaagag caaggccaca      240

ctgactgtag acaaatcctc cagcacagcc tacatgcaac tcagcagcct gacatctgag      300

gactctgcgg tctattactg tttaagatca ctaggctact ttgactactg gggccaaggc      360

accactctca cagtctcctc agccaaaaca acagccccat cggtctatcc actggcccct      420

ggg                                                                    423


<210>  84
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 2G11 antibody

<400>  84

Phe Leu Val Ala Thr Ala Thr Asp Val His Ser Gln Val Gln Leu Gln 
1               5                   10                  15      


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
            20                  25                  30          


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Trp Met His Trp Val 
        35                  40                  45              


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro 
    50                  55                  60                  


Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr 
65                  70                  75                  80  


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                85                  90                  95      


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Leu Arg Ser Leu Gly 
            100                 105                 110         


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala 
        115                 120                 125             


Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly 
    130                 135                 140     


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of the 2G11 antibody

<400>  85

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of the 2G11 antibody

<400>  86

Ile Asn Pro Ser Asn Gly Arg Ala 
1               5               


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of the 2G11 antibody

<400>  87

Leu Arg Ser Leu Gly Tyr Phe Asp Tyr 
1               5                   


<210>  88
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the 2G11 antibody

<400>  88
aagttgcctg ttaggctgtt ggtgctgatg ttctggattc ctgcttccag cagtgatgtt       60

gtgatgaccc aaagtccact ctccctgcct gtcagtcttg gagatcaagc ctccatctct      120

tgcagatcta gtcagagcct tgtacacagt aatggaaaca cctatttaca ttggtacctg      180

cagaaggcag gccagtctcc aaagttcctg atctacaaag tttccaaccg attttctggg      240

gtcccagaca ggttcagtgg cagtggatca gggacagatt tcacactcaa gatcagcaga      300

gtggaggctg aggatctggg agtttatttc tgctctcaaa gtacacatgt tccgtacacg      360

ttcggagggg ggaccaagct ggaaataaaa cgggctgatg ctgcaccaac tgtatccatc      420

ttcccaccat ccagt                                                       435


<210>  89
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 2G11 antibody

<400>  89

Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala Ser 
1               5                   10                  15      


Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser 
            20                  25                  30          


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
        35                  40                  45              


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Ala Gly 
    50                  55                  60                  


Gln Ser Pro Lys Phe Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
            100                 105                 110         


Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 


Ser 
145 


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1 of the 2G11 antibody

<400>  90

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  91
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2 of the 2G11 antibody

<400>  91

Lys Val Ser 
1           


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3 of the 2G11 antibody

<400>  92

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  93
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the heavy chain of the 1H5 antibody

<400>  93
agcttgattt tccttgtcct tgttttaaaa ggtgtccagt gtgaggtgaa gctggtggag       60

tctgggggag gcttagtgaa gcctggaggg tccctgaaac tctcctgtgc agcctctgga      120

ttcactttca gaagttatgc catgtcttgg gttcgccaga ctccagaaaa ggggctggag      180

tgggtcgcat ccattagtag tggtggtagc acctactatc cagacagtgt gaagggccga      240

ttcaccatct ccagagataa tgccgggaac atcctgtacc tgcaaatgag cagtctgagg      300

tctgaggaca cggccatgta ttactgtgca agaggctatg atggttacta cgagaggata      360

tggtactatg ctatggacta ttggggtcaa ggaacctcag tcaccgtctc ctcagccaaa      420

acgacacccc catctgtcta t                                                441


<210>  94
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 1H5 antibody

<400>  94

Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly Val Gln Cys Glu Val 
1               5                   10                  15      


Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
            20                  25                  30          


Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr Ala Met 
        35                  40                  45              


Ser Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val Ala Ser 
    50                  55                  60                  


Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg 
65                  70                  75                  80  


Phe Thr Ile Ser Arg Asp Asn Ala Gly Asn Ile Leu Tyr Leu Gln Met 
                85                  90                  95      


Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly 
            100                 105                 110         


Tyr Asp Gly Tyr Tyr Glu Arg Ile Trp Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr 
145         


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1 of the 1H5 antibody

<400>  95

Gly Phe Thr Phe Arg Ser Tyr Ala 
1               5               


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2 of the 1H5 antibody

<400>  96

Ile Ser Ser Gly Gly Ser Thr 
1               5           


<210>  97
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3 of the 1H5 antibody

<400>  97

Ala Arg Gly Tyr Asp Gly Tyr Tyr Glu Arg Ile Trp Tyr Tyr Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  98
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the 1H5 antibody

<400>  98
caggtctttg tatacatgtt gctgtggttg tctggtgttg atggagacat tgtgatgacc       60

cagtctcaaa aattcatgtc cacatcagta ggagacaggg tcactgtctc ctgcaaggcc      120

agtcagaatg tgggtactat tgtagcctgg tatcaacaaa aaccaggtca atctcctaaa      180

gcactgattt actcggcatc ctaccggttc agtggagtcc ctgatcgctt cacaggcagt      240

ggatctggga cagatttcac tctcaccatc agcaatgtgc agtctgaaga cttggcagag      300

tatttctgtc agcaatataa cacctatcct ctcacgttcg gctcggggac aaagttggaa      360

ataaaacggg ctgatgctgc accaactgta tccatcttcc caccatccag t               411


<210>  99
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 1H5 antibody

<400>  99

Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser Gly Val Asp Gly Asp 
1               5                   10                  15      


Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly Asp 
            20                  25                  30          


Arg Val Thr Val Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Ile Val 
        35                  40                  45              


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr 
    50                  55                  60                  


Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu 
                85                  90                  95      


Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
            100                 105                 110         


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
        115                 120                 125             


Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135         


<210>  100
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1 of the 1H5 antibody

<400>  100

Gln Asn Val Gly Thr Ile 
1               5       


<210>  101
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2 of the 1H5 antibody

<400>  101

Ser Ala Ser 
1           


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3 of the 1H5 antibody

<400>  102

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  103
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #2a

<400>  103

Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu 
1               5                   10                  15      


Gly Ser Lys Asp 
            20  


<210>  104
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #2b

<400>  104

Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe 
1               5                   10                  15      


Ser Thr Asp Ser 
            20  


<210>  105
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #40a

<400>  105

Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu 
1               5                   10                  15      


Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe 
            20                  25                  30          


Tyr Tyr Leu Glu Gly Ser Lys Asp 
        35                  40  


<210>  106
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide #40b

<400>  106

Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe 
1               5                   10                  15      


Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile 
            20                  25                  30          


Gly Arg Asn Pro Asp Tyr Gly Tyr 
        35                  40  


<210>  107
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide corresponding to residues Phe129-Tyr134 of FC5DIE3IR

<400>  107

Phe Arg Lys Tyr Phe Tyr 
1               5       


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide corresponding to residues Asn121-Asp128 of FC5DIE3IR

<400>  108

Asn Thr Leu Glu Ser Glu Glu Asp 
1               5               


<210>  109
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, heavy chain of the 3A8 antibody

<400>  109

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Tyr Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  110
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, light chain of the 3A8 antibody

<400>  110

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ile 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  111
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, heavy chain of the 1G5 antibody

<400>  111

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Asn Ser Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Tyr Asp Tyr Asp Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  112
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, light chain of the 1G5 antibody

<400>  112

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Val Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  113
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 1B6 antibody without leader sequence

<400>  113

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Gly Ala Asn Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125         


<210>  114
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, heavy chain of the 1B6 antibody

<400>  114

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Gly Ala Asn Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  115
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 1B6 antibody without leader sequence

<400>  115

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125             


Val 
    


<210>  116
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, light chain of the 1B6 antibody

<400>  116

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  117
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 2G11 antibody without leader sequence

<400>  117

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Ser Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly 
    130 


<210>  118
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, heavy chain of the 2G11 antibody

<400>  118

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Ser Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  119
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 2G11 antibody without leader sequence

<400>  119

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Ala Gly Gln Ser 
        35                  40                  45              


Pro Lys Phe Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125         


<210>  120
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, light chain of the 2G11 antibody

<400>  120

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Ala Gly Gln Ser 
        35                  40                  45              


Pro Lys Phe Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  121
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the 1H5 antibody without leader sequence

<400>  121

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gly Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Gly Tyr Tyr Glu Arg Ile Trp Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Pro Pro Ser Val Tyr 
    130             


<210>  122
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, heavy chain of the 1H5 antibody

<400>  122

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gly Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Gly Tyr Tyr Glu Arg Ile Trp Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  123
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the 1H5 antibody without leader sequence

<400>  123

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Ile 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120         


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region, light chain of the 1H5 antibody

<400>  124

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Ile 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  125
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the heavy chain of the recombinant 
       chimeric human-mouse hFc-F233-3A8 antibody

<400>  125
atgcctctgc tgctgctgct gcctctgctg tgggccgggg ctctggctca ggtccagctg       60

cagcagcctg gtgccgaact ggtcaagcca ggcgccagcg tgaagctgtc ttgcaaggct      120

tccggctaca ccttcacaaa ctattggatg cactgggtga agcagaggcc cggacagggc      180

ctggagtgga tcggagagat caaccctagc aatggccggg ccaactacaa tgagaagttt      240

aagtctaagg ctaccctgac agtggacaag tccagctcta ccgcctatat gcagctgtcc      300

agcctgacat ctgaggattc cgccgtgtac tattgtgcta ggtctccata cggttactac      360

gactattggg ggcaggggac aactctgact gtgagcagcg ctagcacaaa agggccatcc      420

gtgtttcctc tggctccatc ctcaaaatca acttctgggg ggactgctgc tctgggctgc      480

ctggtgaagg actacttccc agagcccgtc accgtgtcat ggaacagcgg agcactgact      540

agcggagtcc acacctttcc agcagtgctg cagagctccg gactgtactc cctgtctagt      600

gtggtcacag tgccttcaag ctccctgggg actcagacct atatctgcaa cgtgaatcac      660

aagccctcca atactaaggt cgacaaacga gtggagccta agtcttgtga taaaacacat      720

acttgccccc cttgtcctgc accagaactg ctgggaggac ctagcgtgtt cctgtttcca      780

cccaagccaa aagacaccct gatgattagt agaacccctg aggtcacatg cgtggtcgtg      840

gacgtgagcc acgaggaccc cgaagtcaag ttcaactggt acgtggatgg cgtcgaagtg      900

cataatgcta agacaaaacc ccgggaggaa cagtacaaca gtacctatag agtcgtgtca      960

gtcctgacag tgctgcatca ggattggctg aacgggaaag agtataagtg caaagtgtcc     1020

aataaggccc tgcccgctcc tatcgagaaa actatttcta aggctaaagg ccagccaagg     1080

gaaccccagg tgtacaccct gcctccatca cgcgaggaaa tgacaaagaa ccaggtcagc     1140

ctgacttgtc tggtgaaagg gttctatcca tctgacatcg cagtggagtg ggaaagtaat     1200

ggacagcccg aaaacaatta caagaccaca ccccctgtgc tggactccga tggatctttc     1260

tttctgtata gcaagctgac cgtggataaa tcccggtggc agcagggcaa tgtcttttct     1320

tgtagtgtga tgcacgaagc cctgcataac cattacaccc agaaaagcct gagcctgtcc     1380

cccggcaag                                                             1389


<210>  126
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the recombinant chimeric human-mouse hFc-F233-3A8 
       antibody with signal peptide

<400>  126

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
            20                  25                  30          


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
        35                  40                  45              


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    50                  55                  60                  


Gly Glu Ile Asn Pro Ser Asn Gly Arg Ala Asn Tyr Asn Glu Lys Phe 
65                  70                  75                  80  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
                85                  90                  95      


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Ser Pro Tyr Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  127
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the  recombinant 
       chimeric human-mouse hFc-F233-3A8 antibody

<400>  127
atgcggctgc ctgctcagct gctgggcctg ctgatgctgt gggtgtccgg ctcctctggg       60

gatgtgctga tgactcagac tcctctgagc ctgccagtgt ctctgggcga ccaggcctct      120

atctcctgca gatccagcca gtccctgctg cacagcaacg gcaataccta cttccattgg      180

tatctgcaga agcccggcca gtctcctaag ctgctgatct acaaggtgtc caacaggttc      240

tttggcgtgc ccgaccggtt cagcggatct ggatccggca ccgacttcac cctgaagatc      300

agccgcgtgg aggctgaaga cctgggcgtg tatttttgtt cacagattac tcatgtcccc      360

ctgacctttg gtgccggtac caaagtggag atcaagcgaa ctgtggccgc tccaagtgtc      420

ttcatttttc caccctccga cgaacagctg aagagcggaa cagcatctgt ggtctgtctg      480

ctgaacaatt tctaccccag ggaagctaaa gtgcagtgga aggtcgataa cgcactgcag      540

tctggcaata gtcaggagtc agtgacagaa caggactcca aagatagcac ttattctctg      600

tctagtaccc tgacactgtc taaggccgac tacgagaagc ataaagtgta tgcttgtgaa      660

gtcactcatc aggggctgtc ttctccagtg accaagtcct tcaatagggg cgaatgt         717


<210>  128
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the recombinant chimeric human-mouse hFc-F233-3A8 
       antibody with signal peptide

<400>  128

Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Ser 
1               5                   10                  15      


Gly Ser Ser Gly Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Phe Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
            100                 105                 110         


Cys Ser Gln Ile Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  129
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the heavy chain of the  recombinant 
       chimeric human-mouse hFc-F236-1B6 antibody

<400>  129
atgcctctgc tgctgctgct gcctctgctg tgggctgggg ctctggctca ggtccagctg       60

aaagaaagcg gtcccggtct ggtcgcccca tcccagagcc tgtctatcac ctgcacagtg      120

agcggcttct ccctgagcag gtacaacgtg cactgggtgc ggcagccacc tggcaagggc      180

ctggagtggc tgggaatgat ctggggagga ggctctaccg actataattc cgccctgaag      240

agcagactgt ctatctccaa ggataacagc aagtctcagg tgtttctgaa gatgaactcc      300

ctgcagaccg acgatacagc catgtactat tgtgctcgca acggtgccaa ctgggactgg      360

tttgcctact ggggtcaggg aactctggtc actgtcagca gcgctagcac aaaagggcca      420

tccgtgtttc ctctggctcc atcctcaaaa tcaacttctg gggggactgc tgctctgggc      480

tgcctggtga aggactactt cccagagccc gtcaccgtgt catggaacag cggagcactg      540

actagcggag tccacacctt tccagcagtg ctgcagagct ccggactgta ctccctgtct      600

agtgtggtca cagtgccttc aagctccctg gggactcaga cctatatctg caacgtgaat      660

cacaagccct ccaatactaa ggtcgacaaa cgagtggagc ctaagtcttg tgataaaaca      720

catacttgcc ccccttgtcc tgcaccagaa ctgctgggag gacctagcgt gttcctgttt      780

ccacccaagc caaaagacac cctgatgatt agtagaaccc ctgaggtcac atgcgtggtc      840

gtggacgtga gccacgagga ccccgaagtc aagttcaact ggtacgtgga tggcgtcgaa      900

gtgcataatg ctaagacaaa accccgggag gaacagtaca acagtaccta tagagtcgtg      960

tcagtcctga cagtgctgca tcaggattgg ctgaacggga aagagtataa gtgcaaagtg     1020

tccaataagg ccctgcccgc tcctatcgag aaaactattt ctaaggctaa aggccagcca     1080

agggaacccc aggtgtacac cctgcctcca tcacgcgagg aaatgacaaa gaaccaggtc     1140

agcctgactt gtctggtgaa agggttctat ccatctgaca tcgcagtgga gtgggaaagt     1200

aatggacagc ccgaaaacaa ttacaagacc acaccccctg tgctggactc cgatggatct     1260

ttctttctgt atagcaagct gaccgtggat aaatcccggt ggcagcaggg caatgtcttt     1320

tcttgtagtg tgatgcacga agccctgcat aaccattaca cccagaaaag cctgagcctg     1380

tcccccggca ag                                                         1392


<210>  130
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of the recombinant chimeric human-mouse hFc-F236-1B6 
       antibody with signal peptide

<400>  130

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
            20                  25                  30          


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
        35                  40                  45              


Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
    50                  55                  60                  


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
65                  70                  75                  80  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
                85                  90                  95      


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
            100                 105                 110         


Arg Asn Gly Ala Asn Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  131
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding the light chain of the  recombinant 
       chimeric human-mouse hFc-F236-1B6 antibody

<400>  131
atgcgcctgc ctgctcagct gctgggcctg ctgatgctgt gggtctctgg gtcctctggg       60

gatattgtca tgtctcagtc accaagctct ctgccagtgt ccgtgggcga gaaggtgacc      120

atgtcctgca agtccagcca gagcctgctg tactcttcca accagaagaa ttacctggcc      180

tggtatcagc agaagcccgg ccagtctcct aagctgctga tctattgggc tagcacaagg      240

gagtctggcg tgcccgaccg gttcaccgga tccggaagcg gcacagactt caccctgaca      300

atcagctctg tgaaggccga ggacctggca gtctattatt gtcagcagta ttacagctat      360

ccattcactt ttggcagcgg taccaaagtg gagatcaagc gaactgtggc cgctccaagt      420

gtcttcattt ttccaccctc cgacgaacag ctgaagagcg gaacagcatc tgtggtctgt      480

ctgctgaaca atttctaccc cagggaagct aaagtgcagt ggaaggtcga taacgcactg      540

cagtctggca atagtcagga gtcagtgaca gaacaggact ccaaagatag cacttattct      600

ctgtctagta ccctgacact gtctaaggcc gactacgaga agcataaagt gtatgcttgt      660

gaagtcactc atcaggggct gtcttctcca gtgaccaagt ccttcaatag gggcgaatgt      720


<210>  132
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of the recombinant chimeric human-mouse hFc-F236-1B6 
       antibody with signal peptide

<400>  132

Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Ser 
1               5                   10                  15      


Gly Ser Ser Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


