                         SEQUENCE LISTING

<110>  Rhode Island Hospital
 
<120>  COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE DISEASES BY 
       INHIBITING MICRORNA UP-REGULATION OF RETROTRANSPOSON LINE-1

<130>  21486-641001WO

<150>  62/670,705
<151>  2011-05-11

<150>  62/671,356
<151>  2018-05-14

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct - primer

<400>  1
cggccgcatc ttcttgtg                                                     18


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  2
gtgaccaggc gcccaata                                                     18


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  3
cggctaccac atccaaggaa                                                   20


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  4
gctggaatta ccgcggct                                                     18


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  5
tccaatttac tgaccgtaca ccaa                                              24


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  6
cctgatcctg gcaatttcgg cta                                               23


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  7
agacccacaa ggccctgaag ctga                                              24


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  8
cacatctgcc cccaaaagtc                                                   20


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct -  primer

<400>  9
tgagtggaac acaacttctg c                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  10
caggcaagct ctcttcttgc                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  11
gaggctgagg caggagaatc g                                                 21


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  12
tgtcgcccag gctggagtg                                                    19


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  13
ctcgtctgat ctcggaagct aag                                               23


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  14
gcggtctccc atccaagtac                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  15
ggaccttctg gtcttctggc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  16
ggatgcttag ggttggggtc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  17
gactcaaggg tggatgctgt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  18
ccaactgcga agatccactg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  19
ctgctgctaa tgttcttgac                                                   20


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  20
actggaatcc ctttactctt t                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  21
gctcgtgcct cttgcctaca                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  22
cgtgttctcc tcgtccttga                                                   20


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  23
aacctgctgg tgtgtgacgt tc                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  24
cagcacgagg cttttttgtt gt                                                22


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  25
tccagttgcc ttcttgggac                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  26
gtactccaga agaccagagg                                                   20


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  27
caactatgaa cggctcttgt acct                                              24


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  28
tcgataccca tgattcctcc ct                                                22


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  29
cagcgatcaa caggcgagac                                                   20


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  30
agagatatcc cagcaaacct atcca                                             25


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  31
tctgatgcag caggtggg                                                     18


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  32
agggctctcc agacttctgc tctg                                              24


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  33
ttgttgttcc tacgctacat ctc                                               23


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  34
ccgggcacag tcatagcac                                                    19


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  35
gaagacgttc atcgcggtc                                                    19


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  36
gctgacactt gttgagcaac c                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  37
agccattgct attcgcggat a                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  38
cggaaccgtg tcaaggtaaa g                                                 21


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  39
gaggcacccc gaaacatgg                                                    19


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic cosntruct - primer

<400>  40
acttatagcg agttcccacc a                                                 21


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  41
cccgaagcgc aactctacg                                                    19


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  42
cgctgggact gtgcatagtg                                                   20


<210>  43
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  43
gcgcgcgttt aaacgaacaa gacttaaagg agcc                                   34


<210>  44
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  44
cgcgctcgag tctatgttgg tttcctacat                                        30


<210>  45
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  45
gcgcgtttaa actagatgcc cggttttcct ca                                     32


<210>  46
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  46
cgcgcgctcg agccatacag catttttaaa tg                                     32


<210>  47
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  47
gcgcgtttaa acagtctgtg gtgtcaccaa tc                                     32


<210>  48
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  48
cgcgcgcgcg ctcgagagaa atatttgtca tattct                                 36


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  49
ccagtgtctt ttaattcttg tagaatcttc agg                                    33


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  50
cctgaagatt ctacaagaat taaaagacac tgg                                    33


<210>  51
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  51
gcgcgtttaa accagtgtga cataactgaa ag                                     32


<210>  52
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  52
cgcgctcgag cgaacaatga gattttactg                                        30


<210>  53
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  53
gtaaagctgt ttattaattt gctgaaggtc tcgc                                   34


<210>  54
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  54
gcgagacctt cagcaaatta ataaacagct ttac                                   34


<210>  55
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  55
gtcagataaa ttaatttgtt accaatgcta atggc                                  35


<210>  56
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  56
gccattagca ttggtaacaa attaatttat ctgac                                  35


<210>  57
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  57
ccagtgtctt ttaattcttg tagaatcttc agg                                    33


<210>  58
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  58
cctgaagatt ctacaagaat taaaagacac tgg                                    33


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  59
tgctacttca tcgaccccat                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  60
aaagacctca ccctccatct                                                   20


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  61
tcagccacca tcacagaa                                                     18


<210>  62
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  62
ccagggcaca ccgagta                                                      17


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  63
ctcccagaac atcacctacc a                                                 21


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  64
cgtgaacctg ctattgccct                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  65
ggagaacaca ggcgccgacc                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  66
cggtcacccg cagcttcaca                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  67
ccatcattgc cacgcctgag                                                   20


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  68
tccttgtctc catagcagcc ttc                                               23


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  69
gcccacaggc ataaaaggcc c                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  70
gcccacaggc ataaaaggcc c                                                 21


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  71
atgcggggtt cctgatgtgg                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  72
ggcccaggag gaaaagcatg                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  73
ggccgtggtg aaggtggtgg                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  74
gctgcgtgga ggccatcgtc                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  75
cggctaccac atccaaggaa                                                   20


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  76
gctggaatta ccgcggct                                                     18


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  77
caaacaccgc atattctcac tca                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  78
cttcctgtgt ccatgtgatc tca                                               23


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  79
gaggctgagg caggagaatc g                                                 21


<210>  80
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  80
tgtcgcccag gctggagtg                                                    19


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  81
tcacgaactc tctggactga a                                                 21


<210>  82
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  82
acttttgcat atctcgggca taa                                               23


<210>  83
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  83
gcaccccaat gtgatctgc                                                    19


<210>  84
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  84
cgctacacaa gtcgtagtct gg                                                22


<210>  85
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  85
aaaattgtcc atcatgtcct cgc                                               23


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  86
ccaccaggtc agttgcagtt                                                   20


<210>  87
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic cosntruct - primer

<400>  87
ctgtgcaact tcactaagtc ca                                                22


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  88
caatctgagg acgaattgcc t                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  89
gaggcgtgac agtgctacat c                                                 21


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  90
cagggtctag gtcccagtcc                                                   20


<210>  91
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  91
tgtctgaggc tcattctgc                                                    19


<210>  92
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct - primer

<400>  92
tggggcaggg aaggca                                                       16


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93
aacctggacg aaatggacaa a                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  94
aagtagacca atggaataga a                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95
aagccactat tactctgata c                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construc

<400>  96
aaggtcaaat ctaagtggat c                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  97
aagtttctgc aaggcaaaag a                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  98
aatggctaag atcaaaaatt c                                                 21


<210>  99
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val 
1               5                   10                  15      


His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Met Pro Thr Gly Ile Lys 
            20                  25                  30          


Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile 
        35                  40                  45              


Lys Ser Lys Gly Ile Ala Val Arg Gly Glu Gln Gly Thr Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Ala Gly Pro Arg Gly His Pro Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Pro Gly Tyr Gly Ser Pro Gly Leu Gln Gly Glu Pro Gly Leu 
                85                  90                  95      


Pro Gly Pro Pro Gly Pro Ser Ala Val Gly Lys Pro Gly Val Pro Gly 
            100                 105                 110         


Leu Pro Gly Lys Pro Gly Glu Arg Gly Pro Tyr Gly Pro Lys Gly Asp 
        115                 120                 125             


Val Gly Pro Ala Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Ile Pro Gly Pro Ala Gly Ile Ser Val Pro Gly Lys Pro Gly Gln 
145                 150                 155                 160 


Gln Gly Pro Thr Gly Ala Pro Gly Pro Arg Gly Phe Pro Gly Glu Lys 
                165                 170                 175     


Gly Ala Pro Gly Val Pro Gly Met Asn Gly Gln Lys Gly Glu Met Gly 
            180                 185                 190         


Tyr Gly Ala Pro Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln 
        195                 200                 205             


Gly Pro Thr Gly Pro Ser Gly Pro Pro Gly Val Gly Lys Arg Gly Glu 
    210                 215                 220                 


Asn Gly Val Pro Gly Gln Pro Gly Ile Lys Gly Asp Arg Gly Phe Pro 
225                 230                 235                 240 


Gly Glu Met Gly Pro Ile Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                245                 250                 255     


Glu Arg Gly Pro Glu Gly Ile Gly Lys Pro Gly Ala Ala Gly Ala Pro 
            260                 265                 270         


Gly Gln Pro Gly Ile Pro Gly Thr Lys Gly Leu Pro Gly Ala Pro Gly 
        275                 280                 285             


Ile Ala Gly Pro Pro Gly Pro Pro Gly Phe Gly Lys Pro Gly Leu Pro 
    290                 295                 300                 


Gly Leu Lys Gly Glu Arg Gly Pro Ala Gly Leu Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Ala Lys Gly Glu Gln Gly Pro Ala Gly Leu Pro Gly Lys Pro Gly Leu 
                325                 330                 335     


Thr Gly Pro Pro Gly Asn Met Gly Pro Gln Gly Pro Lys Gly Ile Pro 
            340                 345                 350         


Gly Ser His Gly Leu Pro Gly Pro Lys Gly Glu Thr Gly Pro Ala Gly 
        355                 360                 365             


Pro Ala Gly Tyr Pro Gly Ala Lys Gly Glu Arg Gly Ser Pro Gly Ser 
    370                 375                 380                 


Asp Gly Lys Pro Gly Tyr Pro Gly Lys Pro Gly Leu Asp Gly Pro Lys 
385                 390                 395                 400 


Gly Asn Pro Gly Leu Pro Gly Pro Lys Gly Asp Pro Gly Val Gly Gly 
                405                 410                 415     


Pro Pro Gly Leu Pro Gly Pro Val Gly Pro Ala Gly Ala Lys Gly Met 
            420                 425                 430         


Pro Gly His Asn Gly Glu Ala Gly Pro Arg Gly Ala Pro Gly Ile Pro 
        435                 440                 445             


Gly Thr Arg Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Phe Pro Gly 
    450                 455                 460                 


Ser Lys Gly Asp Pro Gly Ser Pro Gly Pro Pro Gly Pro Ala Gly Ile 
465                 470                 475                 480 


Ala Thr Lys Gly Leu Asn Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly His Ser Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro 
            500                 505                 510         


Pro Gly Pro Pro Gly Gln Ala Val Met Pro Glu Gly Phe Ile Lys Ala 
        515                 520                 525             


Gly Gln Arg Pro Ser Leu Ser Gly Thr Pro Leu Val Ser Ala Asn Gln 
    530                 535                 540                 


Gly Val Thr Gly Met Pro Val Ser Ala Phe Thr Val Ile Leu Ser Lys 
545                 550                 555                 560 


Ala Tyr Pro Ala Ile Gly Thr Pro Ile Pro Phe Asp Lys Ile Leu Tyr 
                565                 570                 575     


Asn Arg Gln Gln His Tyr Asp Pro Arg Thr Gly Ile Phe Thr Cys Gln 
            580                 585                 590         


Ile Pro Gly Ile Tyr Tyr Phe Ser Tyr His Val His Val Lys Gly Thr 
        595                 600                 605             


His Val Trp Val Gly Leu Tyr Lys Asn Gly Thr Pro Val Met Tyr Thr 
    610                 615                 620                 


Tyr Asp Glu Tyr Thr Lys Gly Tyr Leu Asp Gln Ala Ser Gly Ser Ala 
625                 630                 635                 640 


Ile Ile Asp Leu Thr Glu Asn Asp Gln Val Trp Leu Gln Leu Pro Asn 
                645                 650                 655     


Ala Glu Ser Asn Gly Leu Tyr Ser Ser Glu Tyr Val His Ser Ser Phe 
            660                 665                 670         


Ser Gly Phe Leu Val Ala Pro Met 
        675                 680 


<210>  100
<211>  3302
<212>  DNA
<213>  Homo sapiens

<400>  100
accttctgca ctgctcatct gggcagagga agcttcagaa agctgccaag gcaccatctc       60

caggaactcc cagcacgcag aatccatctg agaatatgct gccacaaata ccctttttgc      120

tgctagtatc cttgaacttg gttcatggag tgttttacgc tgaacgatac caaatgccca      180

caggcataaa aggcccacta cccaacacca agacacagtt cttcattccc tacaccataa      240

agagtaaagg tatagcagta agaggagagc aaggtactcc tggtccacca ggccctgctg      300

gacctcgagg gcacccaggt ccttctggac caccaggaaa accaggctac ggaagtcctg      360

gactccaagg agagccaggg ttgccaggac caccgggacc atcagctgta gggaaaccag      420

gtgtgccagg actcccagga aaaccaggag agagaggacc atatggacca aaaggagatg      480

ttggaccagc tggcctacca ggaccccggg gcccaccagg accacctgga atccctggac      540

cggctggaat ttctgtgcca ggaaaacctg gacaacaggg acccacagga gccccaggac      600

ccaggggctt tcctggagaa aagggtgcac caggagtccc tggtatgaat ggacagaaag      660

gggaaatggg atatggtgct cctggtcgtc caggtgagag gggtcttcca ggccctcagg      720

gtcccacagg accatctggc cctcctggag tgggaaaaag aggtgaaaat ggggttccag      780

gacagccagg catcaaaggt gatagaggtt ttccgggaga aatgggacca attggcccac      840

caggtcccca aggccctcct ggggaacgag ggccagaagg cattggaaag ccaggagctg      900

ctggagcccc aggccagcca gggattccag gaacaaaagg tctccctggg gctccaggaa      960

tagctgggcc cccagggcct cctggctttg ggaaaccagg cttgccaggc ctgaagggag     1020

aaagaggacc tgctggcctt cctgggggtc caggtgccaa aggggaacaa gggccagcag     1080

gtcttcctgg gaagccaggt ctgactggac cccctgggaa tatgggaccc caaggaccaa     1140

aaggcatccc gggtagccat ggtctcccag gccctaaagg tgagacaggg ccagctgggc     1200

ctgcaggata ccctggggct aagggtgaaa ggggttcccc tgggtcagat ggaaaaccag     1260

ggtacccagg aaaaccaggt ctcgatggtc ctaagggtaa cccagggtta ccaggtccaa     1320

aaggtgatcc tggagttgga ggacctcctg gtctcccagg ccctgtgggc ccagcaggag     1380

caaagggaat gcccggacac aatggagagg ctggcccaag aggtgcccct ggaataccag     1440

gtactagagg ccctattggg ccaccaggca ttccaggatt ccctgggtct aaaggggatc     1500

caggaagtcc cggtcctcct ggcccagctg gcatagcaac taagggcctc aatggaccca     1560

ccgggccacc agggcctcca ggtccaagag gccactctgg agagcctggt cttccagggc     1620

cccctgggcc tccaggccca ccaggtcaag cagtcatgcc tgagggtttt ataaaggcag     1680

gccaaaggcc cagtctttct gggacccctc ttgttagtgc caaccagggg gtaacaggaa     1740

tgcctgtgtc tgcttttact gttattctct ccaaagctta cccagcaata ggaactccca     1800

taccatttga taaaattttg tataacaggc aacagcatta tgacccaagg actggaatct     1860

ttacttgtca gataccagga atatactatt tttcatacca cgtgcatgtg aaagggactc     1920

atgtttgggt aggcctgtat aagaatggca cccctgtaat gtacacctat gatgaataca     1980

ccaaaggcta cctggatcag gcttcaggga gtgccatcat cgatctcaca gaaaatgacc     2040

aggtgtggct ccagcttccc aatgccgagt caaatggcct atactcctct gagtatgtcc     2100

actcctcttt ctcaggattc ctagtggctc caatgtgagt acacacagag ctaatctaaa     2160

tcttgtgcta gaaaaagcat tctctaactc taccccaccc tacaaaatgc atatggaggt     2220

aggctgaaaa gaatgtaatt tttattttct gaaatacaga tttgagctat cagaccaaca     2280

aaccttcccc ctgaaaagtg agcagcaacg taaaaacgta tgtgaagcct ctcttgaatt     2340

tctagttagc aatcttaagg ctctttaagg ttttctccaa tattaaaaaa tatcaccaaa     2400

gaagtcctgc tatgttaaaa acaaacaaca aaaaacaaac aacaaaaaaa aaattaaaaa     2460

aaaaaacaga aatagagctc taagttatgt gaaatttgat ttgagaaact cggcatttcc     2520

tttttaaaaa agcctgtttc taactatgaa tatgagaact tctaggaaac atccaggagg     2580

tatcatataa ctttgtagaa cttaaatact tgaatattca aatttaaaag acactgtatc     2640

ccctaaaata tttctgatgg tgcactactc tgaggcctgt atggcccctt tcatcaatat     2700

ctattcaaat atacaggtgc atatatactt gttaaagctc ttatataaaa aagccccaaa     2760

atattgaagt tcatctgaaa tgcaaggtgc tttcatcaat gaaccttttc aaacttttct     2820

atgattgcag agaagctttt tatataccca gcataacttg gaaacaggta tctgacctat     2880

tcttatttag ttaacacaag tgtgattaat ttgatttctt taattcctta ttgaatctta     2940

tgtgatatga ttttctggat ttacagaaca ttagcacatg taccttgtgc ctcccattca     3000

agtgaagtta taatttacac tgagggtttc aaaattcgac tagaagtgga gatatattat     3060

ttatttatgc actgtactgt atttttatat tgctgtttaa aacttttaag ctgtgcctca     3120

cttattaaag cacaaaatgt tttacctact ccttatttac gacgcaataa aataacatca     3180

atagattttt aggctgaatt aatttgaaag cagcaatttg ctgttctcaa ccattctttc     3240

aaggcttttc attgttcaaa gttaataaaa aagtaggaca ataaagtgat gggtggcttt     3300

ta                                                                    3302


<210>  101
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  102
<211>  9621
<212>  DNA
<213>  Homo sapiens

<400>  102
acagcgctcg cgctgctctc ggcgctcgca gctgccgact ggggatgacg gcgggcagga       60

ggagaccgca gccgaaggga cacagacacg ccgcttcacc agctcgcctc aggctgcccc      120

cctgcatttt tgttttaatt tttacggctt tttcccctct ctttcttccc ttcctcctgg      180

tcccagcaga gccaaggaaa cccacaaaat aagaaaggaa gtgggccccg gagcttggaa      240

cctccacagc cggcttgtcc agcgcagcgc gggggcggga ggctgcgcgc accagttgcc      300

agcccggtgc gcggtacctt tccttacttt tcttgaaaca gcgatcgtgc ctgcatttgg      360

tggttttttg gtttttgttt ttttcctttt cccgtatttg ctgaatctcc actatccgac      420

tttttttttt taatcttttc tttccccccc cccccacccc acctctttct ggagcacgaa      480

tccaaacatt ttcccaagca acaaagaaaa gttcgcacgc tggcaccgca gcccggacag      540

gctggcgctg ctgccgggcc cccctccctc cgacacttga ctcaatcctg caagcaagtg      600

tgtgtgtgtc cccatccccc gccccgttaa cttcatagca aataacaaat acccataaag      660

tcccagtcgc gcagcccctc cccgcgggca gcgcactatg ctgctcgggt gggcgtccct      720

gctgctgtgc gcgttccgcc tgcccctggc cgcggtcggc cccgccgcga cacctgccca      780

ggataaagcc gggcagcctc cgactgctgc agcagccgcc cagccccgcc ggcggcaggg      840

ggaggaggtg caggagcgag ccgagcctcc cggccacccg caccccctgg cgcagcggcg      900

caggagcaag gggctggtgc agaacatcga ccaactctac tccggcggcg gcaaggtggg      960

ctacctcgtc tacgcgggcg gccggaggtt cctcttggac ctggagcgag atggttcggt     1020

gggcattgct ggcttcgtgc ccgcaggagg cgggacgagt gcgccctggc gccaccggag     1080

ccactgcttc tatcggggca cagtggacgg tagtccccgc tctctggctg tctttgacct     1140

ctgtgggggt ctcgacggct tcttcgcggt caagcacgcg cgctacaccc taaagccact     1200

gctgcgcgga ccctgggcgg aggaagaaaa ggggcgcgtg tacggggatg ggtccgcacg     1260

gatcctgcac gtctacaccc gcgagggctt cagcttcgag gccctgccgc cgcgcgccag     1320

ctgcgaaacc cccgcgtcca caccggaggc ccacgagcat gctccggcgc acagcaaccc     1380

gagcggacgc gcagcactgg cctcgcagct cttggaccag tccgctctct cgcccgctgg     1440

gggctcagga ccgcagacgt ggtggcggcg gcggcgccgc tccatctccc gggcccgcca     1500

ggtggagctg cttctggtgg ctgacgcgtc catggcgcgg ttgtatggcc ggggcctgca     1560

gcattacctg ctgaccctgg cctccatcgc caataggctg tacagccatg ctagcatcga     1620

gaaccacatc cgcctggccg tggtgaaggt ggtggtgcta ggcgacaagg acaagagcct     1680

ggaagtgagc aagaacgctg ccaccacact caagaacttt tgcaagtggc agcaccaaca     1740

caaccagctg ggagatgacc atgaggagca ctacgatgca gctatcctgt ttactcggga     1800

ggatttatgt gggcatcatt catgtgacac cctgggaatg gcagacgttg ggaccatatg     1860

ttctccagag cgcagctgtg ctgtgattga agacgatggc ctccacgcag ccttcactgt     1920

ggctcacgaa atcggacatt tacttggcct ctcccatgac gattccaaat tctgtgaaga     1980

gacctttggt tccacagaag ataagcgctt aatgtcttcc atccttacca gcattgatgc     2040

atctaagccc tggtccaaat gcacttcagc caccatcaca gaattcctgg atgatggcca     2100

tggtaactgt ttgctggacc taccacgaaa gcagatcctg ggccccgaag aactcccagg     2160

acagacctac gatgccaccc agcagtgcaa cctgacattc gggcctgagt actccgtgtg     2220

tcccggcatg gatgtctgtg ctcgcctgtg gtgtgctgtg gtacgccagg gccagatggt     2280

ctgtctgacc aagaagctgc ctgcggtgga agggacgcct tgtggaaagg ggagaatctg     2340

cctgcagggc aaatgtgtgg acaaaaccaa gaaaaaatat tattcaacgt caagccatgg     2400

caactgggga tcttggggat cctggggcca gtgttctcgc tcatgtggag gaggagtgca     2460

gtttgcctat cgtcactgta ataaccctgc tcccagaaac aacggacgct actgcacagg     2520

gaagagggcc atctaccgct cctgcagtct catgccctgc ccacccaatg gtaaatcatt     2580

tcgtcatgaa cagtgtgagg ccaaaaatgg ctatcagtct gatgcaaaag gagtcaaaac     2640

ttttgtggaa tgggttccca aatatgcagg tgtcctgcca gcggatgtgt gcaagctgac     2700

ctgcagagcc aagggcactg gctactatgt ggtattttct ccaaaggtga ccgatggcac     2760

tgaatgtagg ctgtacagta attccgtctg cgtccggggg aagtgtgtga gaactggctg     2820

tgacggcatc attggctcaa agctgcagta tgacaagtgc ggagtatgtg gaggagacaa     2880

ctccagctgt acaaagattg ttggaacctt taataagaaa agtaagggtt acactgacgt     2940

ggtgaggatt cctgaagggg caacccacat aaaagttcga cagttcaaag ccaaagacca     3000

gactagattc actgcctatt tagccctgaa aaagaaaaac ggtgagtacc ttatcaatgg     3060

aaagtacatg atctccactt cagagactat cattgacatc aatggaacag tcatgaacta     3120

tagcggttgg agccacaggg atgacttcct gcatggcatg ggctactctg ccacgaagga     3180

aattctaata gtgcagattc ttgcaacaga ccccactaaa ccattagatg tccgttatag     3240

cttttttgtt cccaagaagt ccactccaaa agtaaactct gtcactagtc atggcagcaa     3300

taaagtggga tcacacactt cgcagccgca gtgggtcacg ggcccatggc tcgcctgctc     3360

taggacctgt gacacaggtt ggcacaccag aacggtgcag tgccaggatg gaaaccggaa     3420

gttagcaaaa ggatgtcctc tctcccaaag gccttctgcg tttaagcaat gcttgttgaa     3480

gaaatgttag cctgtggtta tgatcttatg cacaaagata actggaggat tcagcactga     3540

tgcagtcgtg gtgaacagga ggtctaccta acgcacagaa agtcatgctt cagtgacatt     3600

gtcaacagga gtccaattat gggcagaatc tgctctctgt gaccaaaaga ggatgtgcac     3660

tgcttcacgt gacagtggtg accttgcaat atagaaaaac ttgggagtta ttgaacatcc     3720

cctgggctta caagaaacac tgatgaatgt aaaatcaggg gacatttgaa gatggcagaa     3780

ctgtctcccc cttgtcacct acctctgata gaatgtcttt aatggtatca taatcatttt     3840

cacccataat acacagtagc ttcttcttac tgtttgtaaa tacattctcc cttggtatgt     3900

cactttatat cccctggttc tattaaaata tccatatata tttctataaa aaaagtgttt     3960

gaccaaagta ggtctgcagc tatttcaact tccttccgtt tccagaaaga gctgtggata     4020

ttttactgga aattaagaac ttgctgctgt tttaataaga tgtagtatat tttctgacta     4080

caggagataa aatttcagtc aaaaaaccat tttgacagca agtatcttct gagaaatttt     4140

gaaaagtaaa tagatctcag tgtatctagt cacttaaata catacacggg ttcatttact     4200

taaacctttg actgcctgta tttttttcag gtagctagcc aaattaatgc ataatttcag     4260

atgtagaagt agggtttgcg tgtgtgtgtg tgatcatact caagagtcta aaaactagtt     4320

tccttgtgtt ggaaatttaa aaggaaaaaa atcgtatttc actgtgtttt caatttatat     4380

tttcacaact actttctctc tccagagctt tcatctgata tctcacaatg tatgatatac     4440

gtacaaaaca cacagcaagt tttctatcat gtccaacaca ttcaacactg gtatacctcc     4500

taccagcaag cctttaaaat gcatttgtgt ttgcttattt gttttgttca agggttcagt     4560

aagacctaca atgttttgta tttcttgact tattttatta gaaacattaa agatcacttg     4620

gtagttagcc acattgagaa gtggttatca ttgttaatgt ggttaatgcc aaaaagtggt     4680

taatattaat aagactgttt ccacaccata ggcaataatt tcttaattta aaaaatctaa     4740

gtatattcct attgtactaa atatttttcc caactggaaa gcacttgatt gtacccgtaa     4800

gtgtttgagt gatgacatgt gatgattttc agaaagttgt tgtttttgtt tccatagcct     4860

gtttaagtag gttgtaagtt tgaatagtta gacatggaaa ttattttata agcacacacc     4920

taaagatatc tttttagatg ataaaatgta caccccccca tcaccaacct cacaacttag     4980

aaaatctaag ttgtttgatt tctttgggat ttcttttgtt gtgaaacact gcaaagccaa     5040

tttttcttta taaaaattca tagtaatcct gccaaatgtg cctattgtta aagatttgca     5100

tgtgaagatc ttagggaacc actgtttgag ttctacaagc tcatgagagt ttatttttat     5160

tataagatgt ttttaatata aaagaattat gtaactgatc actatattac atcatttcag     5220

tgggccagga aaatagatgt cttgctgttt tcagtatttt cttaagaaat tgcttttaaa     5280

acaaataatt gttttacaaa accaataatt atcctttgaa ttttcataga ctgactttgc     5340

ttttgacgta gaaatttttt ttctcaataa attatcactt tgagaaatga ggcctgtaca     5400

aggctgataa cctatatgtg atggagatca cccaatgcca agggcagaaa gcaaacctag     5460

ttaaataggt gagaaaaaaa ataataatcc cagtgccatt tgtctgtgca aagagaatta     5520

ggagagaggt taatgttact tttttccatt ttggaaataa ttttaatcaa gtaactcaaa     5580

tgtgacaaaa tttattttta ttttttgtgg ttatattccc aacaacatta aaaaatactc     5640

gaggcataaa tgtagttgtc tcctactctg cttctcttac tatactcata catttttaat     5700

atggtttatc aatgattcat gtttccctca aatagtgatg gtttacacct gtcatggaaa     5760

caatcctaga gagctcagag caattaaacc actattccat gcttttaagt agttttctcc     5820

acctttttct tatgagtctc actagattga ctgaggaatg tatgtctaaa ttcctggaga     5880

agatgatatg gattggaaac tgaaattcag agaaatggag tgttcaatag ataccacgaa     5940

ttgtgaacaa agggaaaatt ctatacaact caatctaagt cagtccactt tgacttcgta     6000

ctgtctttca cctttccatt gttgcatctt gaatttttta aaatgtctag aattcaggat     6060

gctaggggct acttctttaa aaaaaaaaaa aaaaaagaat tcgtctgaaa atgctcaggt     6120

ttgtaagaat ctaatctcac ttacataact aagcactcca taataagttt tattaagtac     6180

aaagggagcc agaaaaaatg acatttattt cttctagatc agaaaaattt aaattaagcc     6240

ctgccttgct gtttagaaat atgtgggcat tgttataatt tattcaataa atttatgttc     6300

ctttgccttc ctgtggaaac agttttatcc cactaaacta ggaattaggg gataaatcac     6360

aaacaaaaaa aaagttgcag cactgaaaaa aagtaattta ttgtttttgc aactggtatg     6420

tgaatttgtg tgataaaatt atttattctt atttaacaaa aatatgttca aatttttcta     6480

tatttaaaat gttttgctgt tgtcctactt tttaatttat gcttcatgtt tgtgtataaa     6540

gtacactttt acactttgtg agtttacata atatacagca ctggttgctt ttgtattttt     6600

ttacagaaag ctttctgtgt gaagcaggtg tatatgtata tattcctcat gtattcttat     6660

tctgatacta tcatttttct ttccaaggaa attttaatct gtcatgacca atagtgttca     6720

ttacttgtgc ctatgataat aggtttttta catcacatta acactatttt ttccaagtca     6780

caaataagaa aaacacttat tcaatgaaac aaggtgcaag ttttaaattt gggtacacaa     6840

atagcctaga agcttcctac agacgctaag acacagccaa taatcagatc ctttcacttc     6900

atcgagaaac ttggacaagt cgatattgat gtattagatg aaagttgtct acacacaact     6960

tctgagggat acaaacgata ataaaaccaa atgttgtctg tttctccttt agaaacacct     7020

cctaaaatta atatcattta gtctctagtg tctgtaggat tctacagatg agcacaaata     7080

gattgggttt gtataacaaa tgctaatagt cataactgtt tctacaaata tggggtgtcc     7140

attaagagaa tgtgatgttt tcctactgct gttgaatccc atggggtgat tataggactt     7200

gaaataggca gagtcacctc tgatgacatc agcttgcctc tgtgatttca cagtctgatc     7260

ctggcaacaa gacaaagcac ccttggacac acagccaatc tctggttgtg atatttcccc     7320

attgattcct tccttgttaa caaggtcatt ttaatggttc aggtgaggac agcagccaga     7380

ttcaaagtcc agaatttgtg ctgttacata gagttcacac tgtcaaataa cattgaattt     7440

aataatgatc aaatttttct agtagtcttt ggcagagtgt ataatctcat tggcatgatt     7500

ggtgaatatt actaatctct ttataatgaa agatgcttta caaatacctt atatttgcta     7560

acatttcaaa actactaaat aaatgaaata gccatgtgta cagaaatggt catttaaagc     7620

tttaatagaa ccaaattcaa gacaatgtat catttagaca cacagaaaag gaacttgtat     7680

gttttcccta ttatttttct catttgccaa caatctatag ttttaggtta tcaaacagat     7740

agatcaactt aactggctag tacattgaaa aatcttccta agaatccttt gttagcataa     7800

tctatagaga taatttctca aattatatca tcatgatgca tataaactct ataatgtata     7860

attgtgtttc atttatttaa tgtatgagaa catattgaaa tacaaaacca tgcattagcc     7920

aaaaaattgg aatacaggta gtgttcagat cagcaaaaca ttcagtctgg taaatgcctg     7980

cctggggcta tgatatcatt ctcaatgcag gttttatgga aaaactaaaa gaatatgttg     8040

ttagatgatg ttggttttga aaaaaaaaag acattaacat acacattagt tagcccagtt     8100

aattgcattc tactaatata gttgcacatt agcaataatt ttgctgtctc tggtctttat     8160

tttgtggctt caactaactg gaccatgtgg actgtaaagg tcaaatggaa aaaacgagca     8220

gtggcccctc atcctgtaag gtactgctac atcagagtga cctaaaagtc taacactgtg     8280

aggaaaactg tgatttgtag gaaaaaaaaa aaaaacaaat aaaaaacagg gcatgctttt     8340

taattttttt ccactttcct ttggcacacc caatgaacaa ttctaatttt tattgaggtg     8400

ctaacatctt tcgtgaccga ctgtcaaatg tggtattttt gagttactat ttttctacat     8460

gattttacag tttgcaagaa agacctctaa gctttgtgtc acggtagggc acaacttgat     8520

actcaaaatt tgaaaaataa gcacatccaa tgattgtttt gaccaacagt ggtcagtgac     8580

gtaaactgca tgtgcatctg aggacattta aggggtcatt aaaatttgag gagcatcagg     8640

ccggagtagc agacttttag atgagtcata tttcagcatt cactaagtcc tcagcattcc     8700

attcaaactg tcgtgtatat ttggcctgat tttttttcaa gctttgcaat aatttatgtt     8760

attggtaaac acttggtgac tatatctcag ccttttcttt aacaactcac aatatattag     8820

aaacacgtct acctatactg agagtatatt tacaatagaa gaacatactg tatgtgactt     8880

tgtaaagcta gacttttgat taagaaatat ataatctctg gatgctattt ttgcattata     8940

cactcaggca caacgtaaac cttgatggct catcttgcta caattacgag ttgaaaaaca     9000

ctacttacgt atttgtatga cctattagtc agaggaaatc atacatatgc tttgtaaata     9060

gactttgcag ataactaaat agactgaaga aatatgttgc atttgataga agcaattgca     9120

taaatatttg gtttctatat tagagtctgt gagtaaagtc aagtaataaa cctaagtagg     9180

tataacagat ttttaaacct tgaaacttgc tttgatggta gagaaaatca ttgaagattt     9240

acatactgta tataagatgt aaaatgtacg ctgcttatta ccctcaattt tccagaagca     9300

atggtatata atgcagttga aaaaccaaaa atcttggaaa actaagacgg gtcttgttta     9360

aaatgtctct cagctttggc aaccttcaaa tcttaatcaa ctatttaaag cattactgtg     9420

tcttgtagcc tgcattccac aacagctctg ttattcaggt aaaagacttg aactgagccg     9480

tttgggacct atactgtaat attttcattg aggaacaata tcctattttg taaagcattt     9540

ccctatgtgt gactttaaac tgtaaaatta aacactgctt ttgtgggttc agtgggcata     9600

ataaatataa attgtaaact a                                               9621


<210>  103
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  103

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  104
<211>  2714
<212>  DNA
<213>  Homo sapiens

<400>  104
aacagtcccc aggcatcacc attcaagatg catccagggg tcctggctgc cttcctcttc       60

ttgagctgga ctcattgtcg ggccctgccc cttcccagtg gtggtgatga agatgatttg      120

tctgaggaag acctccagtt tgcagagcgc tacctgagat catactacca tcctacaaat      180

ctcgcgggaa tcctgaagga gaatgcagca agctccatga ctgagaggct ccgagaaatg      240

cagtctttct tcggcttaga ggtgactggc aaacttgacg ataacacctt agatgtcatg      300

aaaaagccaa gatgcggggt tcctgatgtg ggtgaataca atgttttccc tcgaactctt      360

aaatggtcca aaatgaattt aacctacaga attgtgaatt acacccctga tatgactcat      420

tctgaagtcg aaaaggcatt caaaaaagcc ttcaaagttt ggtccgatgt aactcctctg      480

aattttacca gacttcacga tggcattgct gacatcatga tctcttttgg aattaaggag      540

catggcgact tctacccatt tgatgggccc tctggcctgc tggctcatgc ttttcctcct      600

gggccaaatt atggaggaga tgcccatttt gatgatgatg aaacctggac aagtagttcc      660

aaaggctaca acttgtttct tgttgctgcg catgagttcg gccactcctt aggtcttgac      720

cactccaagg accctggagc actcatgttt cctatctaca cctacaccgg caaaagccac      780

tttatgcttc ctgatgacga tgtacaaggg atccagtctc tctatggtcc aggagatgaa      840

gaccccaacc ctaaacatcc aaaaacgcca gacaaatgtg acccttcctt atcccttgat      900

gccattacca gtctccgagg agaaacaatg atctttaaag acagattctt ctggcgcctg      960

catcctcagc aggttgatgc ggagctgttt ttaacgaaat cattttggcc agaacttccc     1020

aaccgtattg atgctgcata tgagcaccct tctcatgacc tcatcttcat cttcagaggt     1080

agaaaatttt gggctcttaa tggttatgac attctggaag gttatcccaa aaaaatatct     1140

gaactgggtc ttccaaaaga agttaagaag ataagtgcag ctgttcactt tgaggataca     1200

ggcaagactc tcctgttctc aggaaaccag gtctggagat atgatgatac taaccatatt     1260

atggataaag actatccgag actaatagaa gaagacttcc caggaattgg tgataaagta     1320

gatgctgtct atgagaaaaa tggttatatc tattttttca acggacccat acagtttgaa     1380

tacagcatct ggagtaaccg tattgttcgc gtcatgccag caaattccat tttgtggtgt     1440

taagtgtctt tttaaaaatt gttatttaaa tcctgaagag catttggggt aatacttcca     1500

gaagtgcggg gtaggggaag aagagctatc aggagaaagc ttggttctgt gaacaagctt     1560

cagtaagtta tctttgaata tgtagtatct atatgactat gcgtggctgg aaccacattg     1620

aagaatgtta gagtaatgaa atggaggatc tctaaagagc atctgattct tgttgctgta     1680

caaaagcaat ggttgatgat acttcccaca ccacaaatgg gacacatggt ctgtcaatga     1740

gagcataatt taaaaatata tttataagga aattttacaa gggcataaag taaatacatg     1800

catataatga ataaatcatt cttactaaaa agtataaaat agtatgaaaa tggaaatttg     1860

ggagagccat acataaaaga aataaaccaa aggaaaatgt ctgtaataat agactgtaac     1920

ttccaaataa ataattttca ttttgcactg aggatattca gatgtatgtg cccttcttca     1980

cacagacact aacgaaatat caaagtcatt aaagacagga gacaaaagag cagtggtaag     2040

aatagtagat gtggcctttg aattctgttt aattttcact tttggcaatg actcaaagtc     2100

tgctctcata taagacaaat attcctttgc atattataaa ggataaagaa ggatgatgtc     2160

tttttattaa aatatttcag gttcttcaga agtcacacat tacaaagtta aaattgttat     2220

caaaatagtc taaggccatg gcatcccttt ttcataaatt atttgattat ttaagactaa     2280

aagttgcatt ttaaccctat tttacctagc taattattta attgtccagt ttgtcttgga     2340

tatataggct attttctaaa gacttgtata gcatgaaata aaatatatct tataaagtgg     2400

aagtatgtat attaaaaaag agacatccaa attttttttt aaagcagtct actagattgt     2460

gatcccttga gatatggaag gatgcctttt tttctctgca tttaaaaaaa tcccccagca     2520

cttcccacag tgcctattga tacttgggga gggtgcttgg cacttattga atatatgatc     2580

ggccatcaag ggaagaacta ttgtgctcag agacactgtt gataaaaact caggcaaaga     2640

aaatgaaatg catatttgca aagtgtatta ggaagtgttt atgttgttta taataaaaat     2700

atattttcaa caga                                                       2714


<210>  105
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  106
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  106
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca       60

gctatgaact ccttctccac aagcgccttc ggtccagttg ccttctccct ggggctgctc      120

ctggtgttgc ctgctgcctt ccctgcccca gtacccccag gagaagattc caaagatgta      180

gccgccccac acagacagcc actcacctct tcagaacgaa ttgacaaaca aattcggtac      240

atcctcgacg gcatctcagc cctgagaaag gagacatgta acaagagtaa catgtgtgaa      300

agcagcaaag aggcactggc agaaaacaac ctgaaccttc caaagatggc tgaaaaagat      360

ggatgcttcc aatctggatt caatgaggag acttgcctgg tgaaaatcat cactggtctt      420

ttggagtttg aggtatacct agagtacctc cagaacagat ttgagagtag tgaggaacaa      480

gccagagctg tgcagatgag tacaaaagtc ctgatccagt tcctgcagaa aaaggcaaag      540

aatctagatg caataaccac ccctgaccca accacaaatg ccagcctgct gacgaagctg      600

caggcacaga accagtggct gcaggacatg acaactcatc tcattctgcg cagctttaag      660

gagttcctgc agtccagcct gagggctctt cggcaaatgt agcatgggca cctcagattg      720

ttgttgttaa tgggcattcc ttcttctggt cagaaacctg tccactgggc acagaactta      780

tgttgttctc tatggagaac taaaagtatg agcgttagga cactatttta attattttta      840

atttattaat atttaaatat gtgaagctga gttaatttat gtaagtcata tttatatttt      900

taagaagtac cacttgaaac attttatgta ttagttttga aataataatg gaaagtggct      960

atgcagtttg aatatccttt gtttcagagc cagatcattt cttggaaagt gtaggcttac     1020

ctcaaataaa tggctaactt atacatattt ttaaagaaat atttatattg tatttatata     1080

atgtataaat ggtttttata ccaataaatg gcattttaaa aaattca                   1127


<210>  107
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg 
            20                  25                  30          


Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala 
        35                  40                  45              


Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser 
    50                  55                  60                  


Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu 
65                  70                  75                  80  


Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn 
                85                  90                  95      


Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn 
            100                 105                 110         


Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg 
        115                 120                 125             


Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu 
    130                 135                 140                 


His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg 
145                 150                 155                 160 


Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp 
                165                 170                 175     


Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser 
            180                 185                 190         


Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala 
        195                 200                 205             


Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg 
    210                 215                 220                 


Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe 
225                 230                 235                 240 


Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala 
                245                 250                 255     


Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr 
            260                 265                 270         


Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala 
        275                 280                 285             


Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val 
    290                 295                 300                 


Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val 
305                 310                 315                 320 


Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly 
                325                 330                 335     


Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala 
            340                 345                 350         


Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His 
        355                 360                 365             


Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr 
    370                 375                 380                 


Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser 
385                 390                 395                 400 


Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser 
                405                 410     


<210>  108
<211>  2473
<212>  DNA
<213>  Homo sapiens

<400>  108
actcggcccc gggctgcgcc gcagacggca gcagctcccg ctccgcccga gccgcctgac       60

cgccgggccg gggtgctaac cgcggggccc tgcagcccgc cggcccggcc agcccagccc      120

agcccggcgg cccgcagccc cgccgcccgc cgccccccgc cgccgccgcg ttgccaaaac      180

aaacgggccg gcctatttat tggcggccgg cgagcccggc agctcagagt cgaggcgccg      240

agggggacag cgcgccgcca ccagctcggg ccctgggccc ccgccccgca cttgagtccc      300

gccggccctg gccgcaccac gccgcccatg gcgcccccgc ctggagcccc ccggagccac      360

ccggacgcct gagcccccgc agcgctcccg tcgacgcgcc tgcccatcag cccaccagga      420

gacctcgccc gccgctcccc cgggctcccc ggccatgtct cccgcccggc tccggccccg      480

actgcacttc tgcctggtcc tgttgctgct gctggtggtg ccggcggcat ggggctgcgg      540

gccgggtcgg gtggtgggca gccgccggcg accgccacgc aaactcgtgc cgctcgccta      600

caagcagttc agccccaatg tgcccgagaa gaccctgggc gccagcggac gctatgaagg      660

caagatcgct cgcagctccg agcgcttcaa ggagctcacc cccaattaca atccagacat      720

catcttcaag gacgaggaga acacaggcgc cgaccgcctc atgacccagc gctgcaagga      780

ccgcctgaac tcgctggcta tctcggtgat gaaccagtgg cccggtgtga agctgcgggt      840

gaccgagggc tgggacgagg acggccacca ctcagaggag tccctgcatt atgagggccg      900

cgcggtggac atcaccacat cagaccgcga ccgcaataag tatggactgc tggcgcgctt      960

ggcagtggag gccggctttg actgggtgta ttacgagtca aaggcccacg tgcattgctc     1020

cgtcaagtcc gagcactcgg ccgcagccaa gacgggcggc tgcttccctg ccggagccca     1080

ggtacgcctg gagagtgggg cgcgtgtggc cttgtcagcc gtgaggccgg gagaccgtgt     1140

gctggccatg ggggaggatg ggagccccac cttcagcgat gtgctcattt tcctggaccg     1200

cgagcctcac aggctgagag ccttccaggt catcgagact caggaccccc cacgccgcct     1260

ggcactcaca cccgctcacc tgctctttac ggctgacaat cacacggagc cggcagcccg     1320

cttccgggcc acatttgcca gccacgtgca gcctggccag tacgtgctgg tggctggggt     1380

gccaggcctg cagcctgccc gcgtggcagc tgtctctaca cacgtggccc tcggggccta     1440

cgccccgctc acaaagcatg ggacactggt ggtggaggat gtggtggcat cctgcttcgc     1500

ggccgtggct gaccaccacc tggctcagtt ggccttctgg cccctgagac tctttcacag     1560

cttggcatgg ggcagctgga ctccggggga gggtgtgcat tggtaccccc agctgctcta     1620

ccgcctgggg cgtctcctgc tagaagaggg cagcttccac ccactgggca tgtccggggc     1680

agggagctga aaggactcca ccgctgccct cctggaactg ctgtactggg tccagaagcc     1740

tctcagccag gagggagctg gccctggaag ggacctgagc tgggggacac tggctcctgc     1800

catctcctct gccatgaaga tacaccattg agacttgact gggcaacacc agcgtccccc     1860

acccccgtcg tggtgtagtc atagagctgc aagctgagct ggcgagggga tggttgttga     1920

cccctctctc ctagagacct tgaggctggc acggcgactc ccaactcagc ctgctctcac     1980

tacgagtttt catactctgc ctcccccatt ggggagggcc cattccatcc atcttaggcc     2040

cctttgggtg ggcttgcgcc tcagttgatg ctgctaaatt ccctgggagc cagcatggat     2100

ctggctggac ccgatgctgt ccagaactgg gaaggccaca ggggtggggc agccatcccg     2160

gccattctga ggtatgacat tcctccccgg ccacactcct caagacacat ccagagactg     2220

ttgctgtctg tgggcagagt tctgtgttct ggccaatgtg accgtagtgc cggggactgg     2280

gggaggtggg ttggatgtgc ttgccacccc cccggctaag ctcccccttc tgctgaacca     2340

tgatccccac cccctccgcc ggtcagtctc ccatacctta tttattggag tggaggggga     2400

agcccatggg agaattttgg ggatgttttg gtcttttctt ccttttgtaa taaaaattat     2460

ttaagttgtt aga                                                        2473


<210>  109
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
1               5                   10                  15      


Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
            20                  25                  30          


Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
        35                  40                  45              


Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
    50                  55                  60                  


Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile 
65                  70                  75                  80  


Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn 
                85                  90                  95      


Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala 
            100                 105                 110         


Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly 
        115                 120                 125             


Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp 
    130                 135                 140                 


Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp 
145                 150                 155                 160 


Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val 
                165                 170                 175     


Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu 
            180                 185                 190         


Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser 
        195                 200                 205             


Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp 
    210                 215                 220                 


Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn 
225                 230                 235                 240 


Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu 
                245                 250                 255     


Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys 
            260                 265                 270         


Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile 
        275                 280                 285             


Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val 
305                 310                 315                 320 


Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr 
                325                 330                 335     


Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile 
            340                 345                 350         


Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly 
        355                 360                 365             


Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser 
    370                 375                 380                 


Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg 
385                 390                 395                 400 


Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser 
                405                 410                 415     


Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro 
            420                 425                 430         


Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val 
        435                 440                 445             


Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val 
    450                 455                 460                 


Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg 
465                 470                 475                 480 


Pro Thr Glu Asp Ser Lys Glu Phe Ser 
                485                 


<210>  110
<211>  2138
<212>  DNA
<213>  Homo sapiens

<400>  110
acagaccccg gtgacggaag tgacgtaagg ccggggctgg agggcagtgc tgggctggtc       60

ccgcaggcgc tcggggttgg agccagcgac cgtcggtagc agcatggctc tcctctttct      120

cctacccctt gtcatgcagg gtgtgagcag ggctgagatg ggcaccgcgg atctggggcc      180

gtcctcagtg cctacaccaa ctaatgttac aattgaatcc tataacatga accctatcgt      240

atattgggag taccagatca tgccacaggt ccctgttttt accgtagagg taaagaacta      300

tggtgttaag aattcagaat ggattgatgc ctgcatcaat atttctcatc attattgtaa      360

tatttctgat catgttggtg atccatcaaa ttctctttgg gtcagagtta aagccagggt      420

tggacaaaaa gaatctgcct atgcaaagtc agaagaattt gctgtatgcc gagatggaaa      480

aattggacca cctaaactgg atatcagaaa ggaggagaag caaatcatga ttgacatatt      540

tcacccttca gtttttgtaa atggagacga gcaggaagtc gattatgatc ccgaaactac      600

ctgttacatt agggtgtaca atgtgtatgt gagaatgaac ggaagtgaga tccagtataa      660

aatactcacg cagaaggaag atgattgtga cgagattcag tgccagttag cgattccagt      720

atcctcactg aattctcagt actgtgtttc agcagaagga gtcttacatg tgtggggtgt      780

tacaactgaa aagtcaaaag aagtttgtat taccattttc aatagcagta taaaaggttc      840

tctttggatt ccagttgttg ctgctttact actctttcta gtgcttagcc tggtattcat      900

ctgtttttat attaagaaaa ttaatccatt gaaggaaaaa agcataatat tacccaagtc      960

cttgatctct gtggtaagaa gtgctacttt agagacaaaa cctgaatcaa aatatgtatc     1020

actcatcacg tcataccagc cattttcctt agaaaaggag gtggtctgtg aagagccgtt     1080

gtctccagca acagttccag gcatgcatac cgaagacaat ccaggaaaag tggaacatac     1140

agaagaactt tctagtataa cagaagtggt gactactgaa gaaaatattc ctgacgtggt     1200

cccgggcagc catctgactc caatagagag agagagttct tcacctttaa gtagtaacca     1260

gtctgaacct ggcagcatcg ctttaaactc gtatcactcc agaaattgtt ctgagagtga     1320

tcactccaga aatggttttg atactgattc cagctgtctg gaatcacata gctccttatc     1380

tgactcagaa tttcccccaa ataataaagg tgaaataaaa acagaaggac aagagctcat     1440

aaccgtaata aaagccccca cctcctttgg ttatgataaa ccacatgtgc tagtggatct     1500

acttgtggat gatagcggta aagagtcctt gattggttat agaccaacag aagattccaa     1560

agaattttca tgagatcagc taagttgcac caactttgaa gtctgatttt cctggacagt     1620

tttctgcttt aatttcatga aaagattatg atctcagaaa ttgtatctta gttggtatca     1680

accaaatgga gtgacttagt gtacatgaaa gcgtaaagag gatgtgtggc attttcactt     1740

ttggcttgta aagtacagac tttttttttt ttttaaacaa aaaaagcatt gtaacttatg     1800

aacctttaca tccagatagg ttaccagtaa cggaacagta tccagtactc ctggttccta     1860

ggtgagcagg tgatgcccca gggacctttg tagccacttc actttttttc ttttctctgc     1920

cttggtatag catatgtttt tgtaagttta tgcatacagt aattttaagt aatttcagaa     1980

gaaattctgc aagcttttca aaattggact taaaatctaa ttcaaactaa tagaattaat     2040

ggaatatgta aatagaaacg tgtatatttt ttatgaaaca ttacagttag agatttttaa     2100

ataaagaatt ttaaaactcg aaaaaaaaaa aaaaaaaa                             2138


<210>  111
<211>  2431
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Asp Gln Glu  Val Cys Glu 
    2270                 2275                 2280             


Glu Gly  Trp Asn Lys Tyr Gln  Gly His Cys Tyr Arg  His Phe Pro 
    2285                 2290                 2295             


Asp Arg  Glu Thr Trp Val Asp  Ala Glu Arg Arg Cys  Arg Glu Gln 
    2300                 2305                 2310             


Gln Ser  His Leu Ser Ser Ile  Val Thr Pro Glu Glu  Gln Glu Phe 
    2315                 2320                 2325             


Val Asn  Asn Asn Ala Gln Asp  Tyr Gln Trp Ile Gly  Leu Asn Asp 
    2330                 2335                 2340             


Arg Thr  Ile Glu Gly Asp Phe  Arg Trp Ser Asp Gly  His Pro Met 
    2345                 2350                 2355             


Gln Phe  Glu Asn Trp Arg Pro  Asn Gln Pro Asp Asn  Phe Phe Ala 
    2360                 2365                 2370             


Ala Gly  Glu Asp Cys Val Val  Met Ile Trp His Glu  Lys Gly Glu 
    2375                 2380                 2385             


Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu Pro Phe  Thr Cys Lys 
    2390                 2395                 2400             


Lys Gly  Thr Ala Thr Thr Tyr  Lys Arg Arg Leu Gln  Lys Arg Ser 
    2405                 2410                 2415             


Ser Arg  His Pro Arg Arg Ser  Arg Pro Ser Thr Ala  His 
    2420                 2425                 2430     


<210>  112
<211>  8543
<212>  DNA
<213>  Homo sapiens

<400>  112
cacctacctc cccgccgctc cagagggggc tcgcagagct gaggacgcgc gcagcgctgc       60

tcaaggtctc tctctctcag caccctcgcc ggccggcgtc tgacgcgggt gccagggtct      120

ccgggcacct ttcagtgtcc attccctcag ccagccagga ctccgcaacc cagcagttgc      180

cgctgcggcc acagcccgag gggacctgcg gacaggacgc cggcaggagg aggggtgcgc      240

agcgcccgcg cagagcgtct ccctcgctac gcagcgagac ccgggcctcc cggccccagg      300

agcccccagc tgcctcgcca ggtgtgtggg actgaagttc ttggagaagg gagtccaact      360

cttcaaggtg aactatgacc actttactct gggttttcgt gactctgagg gtcatcactg      420

cagctgtcac tgtagaaact tcagaccatg acaactcgct gagtgtcagc atcccccaac      480

cgtccccgct gagggtcctc ctggggacct ccctcaccat cccctgctat ttcatcgacc      540

ccatgcaccc tgtgaccacc gccccttcta ccgccccact ggccccaaga atcaagtgga      600

gccgtgtgtc caaggagaag gaggtagtgc tgctggtggc cactgaaggg cgcgtgcggg      660

tcaacagtgc ctatcaggac aaggtctcac tgcccaacta cccggccatc cccagtgacg      720

ccaccttgga agtccagagc ctgcgctcca atgactctgg ggtctaccgc tgcgaggtga      780

tgcatggcat cgaggacagc gaggccaccc tggaagtcgt ggtgaaaggc atcgtgttcc      840

attacagagc catctctaca cgctacaccc tcgactttga cagggcgcag cgggcctgcc      900

tgcagaacag tgccatcatt gccacgcctg agcagctgca ggccgcctac gaagacggct      960

tccaccagtg tgacgccggc tggctggctg accagactgt cagatacccc atccacactc     1020

cccgggaagg ctgctatgga gacaaggatg agtttcctgg tgtgaggacg tatggcatcc     1080

gagacaccaa cgagacctat gatgtgtact gcttcgccga ggagatggag ggtgaggtct     1140

tttatgcaac atctccagag aagttcacct tccaggaagc agccaatgag tgccggcggc     1200

tgggtgcccg gctggccacc acgggccagc tctacctggc ctggcaggct ggcatggaca     1260

tgtgcagcgc cggctggctg gccgaccgca gcgtgcgcta ccccatctcc aaggcccggc     1320

ccaactgcgg tggcaacctc ctgggcgtga ggaccgtcta cgtgcatgcc aaccagacgg     1380

gctaccccga cccctcatcc cgctacgacg ccatctgcta cacaggtgaa gactttgtgg     1440

acatcccaga aaacttcttt ggagtggggg gtgaggagga catcaccgtc cagacagtga     1500

cctggcctga catggagctg ccactgcctc gaaacatcac tgagggtgaa gcccgaggca     1560

gcgtgatcct taccgtaaag cccatcttcg aggtctcccc cagtcccctg gaacccgagg     1620

agcccttcac gtttgcccct gaaatagggg ccactgcctt cgctgaggtt gagaatgaga     1680

ctggagaggc caccaggccc tggggctttc ccacacctgg cctgggccct gccacggcat     1740

tcaccagtga ggacctcgtc gtgcaggtga ccgctgtccc tgggcagccg catttgccag     1800

ggggggtcgt cttccactac cgcccgggac ccacccgcta ctcgctgacc tttgaggagg     1860

cacagcaggc ctgcctgcgc acgggggcgg tcattgcctc gccggagcag ctccaggccg     1920

cctacgaagc aggctatgag cagtgtgacg ccggctggct gcgggaccag accgtcagat     1980

accccattgt gagcccccgg accccatgcg tgggtgacaa ggacagcagc ccaggggtca     2040

ggacctatgg cgtgcgccca tcaacagaga cctacgatgt ctactgcttt gtagacagac     2100

ttgaggggga ggtgttcttc gccacacgcc ttgagcagtt caccttccag gaagcactgg     2160

agttctgtga atctcacaat gctacgctgg ccaccacggg ccagctctac gccgcctgga     2220

gccgcggcct ggacaagtgc tatgccggct ggctggccga cggcagcctc cgctacccca     2280

tcgtcacccc aaggcctgcc tgcggtgggg acaagccagg cgtgagaacg gtctacctct     2340

accctaacca gacgggcctc ccagacccac tgtcccggca ccatgccttc tgcttccgag     2400

gcatttcagc ggttccttct ccaggagaag aagagggtgg cacacccaca tcaccctctg     2460

gtgtggagga gtggatcgtg acccaagtgg ttcctggtgt ggctgctgtc cccgtagaag     2520

aggagacaac tgctgtaccc tcaggggaga ctactgccat cctagagttc accaccgagc     2580

cagaaaacca gacagaatgg gaaccagcct ataccccagt gggcacatcc ccgctgccag     2640

ggatccttcc tacttggcct cccactggcg cagcaacaga ggaaagtaca gaaggccctt     2700

ctgcaactga agtgccctct gcctcagagg aaccatcccc ctcagaggtg ccattcccct     2760

cagaggagcc atccccctca gaggaaccat tcccctcagt gaggccattc ccctcagtgg     2820

agctgttccc ctcagaggag ccattcccct ccaaggagcc atccccctca gaggaaccat     2880

cagcctcgga agagccgtat acaccttcac cccccgtgcc cagctggact gagctgccca     2940

gctctgggga ggaatctggg gcccctgatg tcagtggtga cttcacaggc agtggagatg     3000

tttcaggaca ccttgacttc agtgggcagc tgtcagggga cagggcaagt ggactgccct     3060

ctggagacct ggactccagt ggtcttactt ccacagtggg ctcaggcctg cctgtggaaa     3120

gtggactacc ctcaggggat gaagagagaa ttgagtggcc cagcactcct acggttggtg     3180

aactgccctc tggagctgag atcctagagg gctctgcctc tggagttggg gatctcagtg     3240

gacttccttc tggagaagtt ctagagacct ctgcctctgg agtaggagac ctcagtgggc     3300

ttccttctgg agaagttcta gagaccactg cccctggagt agaggacatc agcgggcttc     3360

cttctggaga agttctagag accactgccc ctggagtaga ggacatcagc gggcttcctt     3420

ctggagaagt tctagagacc actgcccctg gagtagagga catcagcggg cttccttctg     3480

gagaagttct agagaccact gcccctggag tagaggacat cagcgggctt ccttctggag     3540

aagttctaga gaccactgcc cctggagtag aggacatcag cgggcttcct tctggagaag     3600

ttctagagac cactgcccct ggagtagagg acatcagcgg gcttccttct ggagaagttc     3660

tagagaccgc tgcccctgga gtagaggaca tcagcgggct tccttctgga gaagttctag     3720

agaccgctgc ccctggagta gaggacatca gcgggcttcc ttctggagaa gttctagaga     3780

ccgctgcccc tggagtagag gacatcagcg ggcttccttc tggagaagtt ctagagaccg     3840

ctgcccctgg agtagaggac atcagcgggc ttccttctgg agaagttcta gagaccgctg     3900

cccctggagt agaggacatc agcgggcttc cttctggaga agttctagag accgctgccc     3960

ctggagtaga ggacatcagc gggcttcctt ctggagaagt tctagagacc gctgcccctg     4020

gagtagagga catcagcggg cttccttctg gagaagttct agagactgct gcccctggag     4080

tagaggacat cagcgggctt ccttctggag aagttctaga gactgctgcc cctggagtag     4140

aggacatcag cgggcttcct tctggagaag ttctagagac tgctgcccct ggagtagagg     4200

acatcagcgg gcttccttct ggagaagttc tagagactgc tgcccctgga gtagaggaca     4260

tcagcgggct tccttctgga gaagttctag agactgctgc ccctggagta gaggacatca     4320

gcgggcttcc ttctggagaa gttctagaga ctgctgcccc tggagtagag gacatcagcg     4380

ggcttccttc tggagaagtt ctagagactg ctgcccctgg agtagaggac atcagcgggc     4440

ttccttctgg agaagttcta gagactgctg cccctggagt agaggacatc agcgggcttc     4500

cttctggaga agttctagag actgctgccc ctggagtaga ggacatcagc gggcttcctt     4560

ctggagaagt tctagagact actgcccctg gagtagagga gatcagcggg cttccttctg     4620

gagaagttct agagactact gcccctggag tagatgagat cagtgggctt ccttctggag     4680

aagttctaga gactactgcc cctggagtag aggagatcag cgggcttcct tctggagaag     4740

ttctagagac ttctacctct gcggtagggg acctcagtgg acttccttct ggaggagaag     4800

ttctagagat ttctgtctct ggagtagagg acatcagtgg gcttccttct ggagaggttg     4860

tagagacttc tgcctctgga atagaggatg tcagtgaact tccttcagga gaaggtctag     4920

agacctctgc ttctggagta gaggacctca gcaggctccc ttctggagaa gaagttctag     4980

agatttctgc ctctggattt ggggacctca gtggacttcc ttctggagga gaaggtctag     5040

agacctctgc ttctgaagta gggactgacc tcagtgggct tccttctgga agggagggtc     5100

tagagacttc agcttctgga gctgaggacc tcagtgggtt gccttctgga aaagaagact     5160

tggtggggtc agcttctgga gacttggact tgggcaaact gccttctgga actctaggaa     5220

gtgggcaagc tccagaaaca agtggtcttc cctctggatt tagtggtgag tattctgggg     5280

tggaccttgg aagtggccca ccctctggcc tgcctgactt tagtggactt ccatctggat     5340

tcccaactgt ttccctagtg gattctacat tggtggaagt ggtcacagcc tccactgcaa     5400

gtgaactgga agggagggga accattggca tcagtggtgc aggagaaata tctggactgc     5460

cctccagtga gctggacatt agtgggagag ctagtggact cccttcagga actgaactca     5520

gtggccaagc atctgggtct cctgatgtca gtggggaaat acctggactc tttggtgtca     5580

gtggacagcc atcagggttt cctgacacta gtggggaaac atctggagtg actgagctta     5640

gcgggctgtc ctctggacaa ccaggtatta gtggagaagc atctggagtt ctttatggca     5700

ctagtcaacc ctttggcata actgatctga gtggagaaac atctggggtc cctgatctca     5760

gtgggcagcc ttcagggtta ccagggttca gtggggcaac atcaggagtc cctgacctgg     5820

tttctggtac cacgagtggc agcggtgaat cttctgggat tacatttgtg gacaccagtt     5880

tggttgaagt ggcccctact acatttaaag aagaagaagg cttagggtct gtggaactca     5940

gtggcctccc ttccggagag gcagatctgt caggcaaatc tgggatggtg gatgtcagtg     6000

gacagttttc tggaacagtc gattccagtg ggtttacatc ccagactccg gaattcagtg     6060

gcctaccaag tggcatagct gaggtcagtg gagaatcctc cagagctgag attgggagca     6120

gcctgccctc gggagcatat tatggcagtg gaactccatc tagtttcccc actgtctctc     6180

ttgtagacag aactttggtg gaatctgtaa cccaggctcc aacagcccaa gaggcaggag     6240

aagggccttc tggcatttta gaactcagtg gtgctcattc tggagcacca gacatgtctg     6300

gggagcattc tggatttctg gacctaagtg ggctgcagtc cgggctgata gagcccagcg     6360

gagagccacc aggtactcca tattttagtg gggattttgc cagcaccacc aatgtaagtg     6420

gagaatcctc tgtagccatg ggcaccagtg gagaggcctc aggacttcca gaagttactt     6480

taatcacttc tgagttcgtg gagggtgtta ctgaaccaac tatttctcag gaactaggcc     6540

aaaggccccc tgtgacacac acaccccagc tttttgagtc cagtggaaaa gtctccacag     6600

ctggggacat tagtggagct accccagtgc tccctgggtc tggagtagaa gtatcatcag     6660

tcccagaatc tagcagtgag acgtccgcct atcctgaagc tgggttcggg gcatctgccg     6720

cccctgaggc cagcagagaa gattctgggt cccctgatct gagtgaaacc acctctgcat     6780

tccacgaagc taaccttgag agatcctctg gcctaggagt gagcggcagc actttgacat     6840

ttcaagaagg cgaggcgtcc gctgccccag aagtgagtgg agaatccacc accaccagtg     6900

atgtggggac agaggcacca ggcttgcctt cagccactcc cacggcttct ggagacagga     6960

ctgaaatcag cggagacctg tctggtcaca cctcgcagct gggcgttgtc atcagcacca     7020

gcatcccaga gtctgagtgg acccagcaga cccagcgccc tgcagagacg catctagaaa     7080

ttgagtcctc aagcctcctg tactcaggag aagagactca cacagtcgaa acagccacct     7140

ccccaacaga tgcttccatc ccagcttctc cggaatggaa acgtgaatca gaatcaactg     7200

ctgcagacca ggaggtatgt gaggagggct ggaacaagta ccagggccac tgttaccgcc     7260

acttcccgga ccgcgagacc tgggtggatg ctgagcgccg gtgtcgggag cagcagtcac     7320

acctgagcag catcgtcacc cccgaggagc aggagtttgt caacaacaat gcccaagact     7380

accagtggat cggcctgaac gacaggacca tcgaagggga cttccgctgg tcagatggac     7440

accccatgca atttgagaac tggcgcccca accagcctga caactttttt gccgctggag     7500

aggactgtgt ggtgatgatc tggcacgaga agggcgagtg gaatgatgtt ccctgcaatt     7560

accacctccc cttcacgtgt aaaaagggca cagccaccac ctacaaacgc agactacaga     7620

agcggagctc acggcaccct cggaggagcc gccccagcac agcccactga gaagagcttc     7680

caggacgcac ccaggacgct gagcccagga gcctgccagg ctgacgtgca tcccacccag     7740

acggtgtcct cttcttgtcg ctttttgtca tataaggaat cccattaaag aaggaaaaaa     7800

ataaatccca catttgtgta tgcacccact cacccctcca aatcagcaaa accgcatcta     7860

atttgtccgc cgaatgccaa agcaaagcaa acttattata acccttggac tgagtttaga     7920

gacatttctt caatttccca tcgtgccttt ccagggacca gtgcagggac agggggagaa     7980

ggggaggggt taagttaaat aaagaagatt atttttgttt cctgacttta tccaagagca     8040

gtgcaatcgt tggttatttc acctccaggg agagctaggg aggagggagg agggctccaa     8100

aggagctgga aggagcagag gcctgagagc aggaagaact cggaaccgca gctgaatgta     8160

ttggatgaga aggagccagg agggctacac catctgtatg agggaaaagc cttgggggag     8220

aggggtgggt tcctgcctcc tgccgagggt aagccggcag gagagagcca tcagagggac     8280

ctccgctgcc tgggagttgg gttccctcca agggtccctc tttcagtgtc ctctctctca     8340

cctgggtctg ccaccctaac aggtggcaac tcggcagggc tgctgggggc acttcctgcc     8400

cagtgggggg tgccgcccaa ccttctcccc tccccacccc cgcccccggg accgtgcagg     8460

caccagggtt ccgtgcacct atttatattt ttgaaaactg aagattataa tattataata     8520

ataataaaga cattggaaga gat                                             8543


<210>  113
<211>  1487
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210>  114
<211>  5059
<212>  DNA
<213>  Homo sapiens

<400>  114
gcagagcgct gctgggctgc cgggtctccc gcttccccct cctgctccaa gggcctcctg       60

catgagggcg cggtagagac ccggacccgc gccgtgctcc tgccgtttcg ctgcgctccg      120

cccgggcccg gctcagccag gccccgcggt gagccatgat tcgcctcggg gctccccaga      180

cgctggtgct gctgacgctg ctcgtcgccg ctgtccttcg gtgtcagggc caggatgtcc      240

aggaggctgg cagctgtgtg caggatgggc agaggtataa tgataaggat gtgtggaagc      300

cggagccctg ccggatctgt gtctgtgaca ctgggactgt cctctgcgac gacataatct      360

gtgaagacgt gaaagactgc ctcagccctg agatcccctt cggagagtgc tgccccatct      420

gcccaactga cctcgccact gccagtgggc aaccaggacc aaagggacag aaaggagaac      480

ctggagacat caaggatatt gtaggaccca aaggacctcc tgggcctcag ggacctgcag      540

gggaacaagg acccagaggg gatcgtggtg acaaaggtga aaaaggtgcc cctggacctc      600

gtggcagaga tggagaacct gggacccctg gaaatcctgg cccccctggt cctcccggcc      660

cccctggtcc ccctggtctt ggtggaaact ttgctgccca gatggctgga ggatttgatg      720

aaaaggctgg tggcgcccag ttgggagtaa tgcaaggacc aatgggcccc atgggacctc      780

gaggacctcc aggccctgca ggtgctcctg ggcctcaagg atttcaaggc aatcctggtg      840

aacctggtga acctggtgtc tctggtccca tgggtccccg tggtcctcct ggtccccctg      900

gaaagcctgg tgatgatggt gaagctggaa aacctggaaa agctggtgaa aggggtccgc      960

ctggtcctca gggtgctcgt ggtttcccag gaaccccagg ccttcctggt gtcaaaggtc     1020

acagaggtta tccaggcctg gacggtgcta agggagaggc gggtgctcct ggtgtgaagg     1080

gtgagagtgg ttccccgggt gagaacggat ctccgggccc aatgggtcct cgtggcctgc     1140

ctggtgaaag aggacggact ggccctgctg gcgctgcggg tgcccgaggc aacgatggtc     1200

agccaggccc cgcagggcct ccgggtcctg tcggtcctgc tggtggtcct ggcttccctg     1260

gtgctcctgg agccaagggt gaagccggcc ccactggtgc ccgtggtcct gaaggtgctc     1320

aaggtcctcg cggtgaacct ggtactcctg ggtcccctgg gcctgctggt gcctccggta     1380

accctggaac agatggaatt cctggagcca aaggatctgc tggtgctcct ggcattgctg     1440

gtgctcctgg cttccctggg ccacggggcc ctcctggccc tcaaggtgca actggtcctc     1500

tgggcccgaa aggtcagacg ggtgaacctg gtattgctgg cttcaaaggt gaacaaggcc     1560

ccaagggaga acctggccct gctggccccc agggagcccc tggacccgct ggtgaagaag     1620

gcaagagagg tgcccgtgga gagcctggtg gcgttgggcc catcggtccc cctggagaaa     1680

gaggtgctcc cggcaaccgc ggtttcccag gtcaagatgg tctggcaggt cccaagggag     1740

cccctggaga gcgagggccc agtggtcttg ctggccccaa gggagccaac ggtgaccctg     1800

gccgtcctgg agaacctggc cttcctggag cccggggtct cactggccgc cctggtgatg     1860

ctggtcctca aggcaaagtt ggcccttctg gagcccctgg tgaagatggt cgtcctggac     1920

ctccaggtcc tcagggggct cgtgggcagc ctggtgtcat gggtttccct ggccccaaag     1980

gtgccaacgg tgagcctggc aaagctggtg agaagggact gcctggtgct cctggtctga     2040

ggggtcttcc tggcaaagat ggtgagacag gtgctgcagg accccctggc cctgctggac     2100

ctgctggtga acgaggcgag cagggtgctc ctgggccatc tgggttccag ggacttcctg     2160

gccctcctgg tcccccaggt gaaggtggaa aaccaggtga ccagggtgtt cccggtgaag     2220

ctggagcccc tggcctcgtg ggtcccaggg gtgaacgagg tttcccaggt gaacgtggct     2280

ctcccggtgc ccagggcctc cagggtcccc gtggcctccc cggcactcct ggcactgatg     2340

gtcccaaagg tgcatctggc ccagcaggcc cccctggggc tcagggccct ccaggtcttc     2400

agggaatgcc tggcgagagg ggagcagctg gtatcgctgg gcccaaaggc gacaggggtg     2460

acgttggtga gaaaggccct gagggagccc ctggaaagga tggtggacga ggcctgacag     2520

gtcccattgg cccccctggc ccagctggtg ctaatggcga gaagggagaa gttggacctc     2580

ctggtcctgc aggaagtgct ggtgctcgtg gcgctccggg tgaacgtgga gagactgggc     2640

cccccggacc agcgggattt gctgggcctc ctggtgctga tggccagcct ggggccaagg     2700

gtgagcaagg agaggccggc cagaaaggcg atgctggtgc ccctggtcct cagggcccct     2760

ctggagcacc tgggcctcag ggtcctactg gagtgactgg tcctaaagga gcccgaggtg     2820

cccaaggccc cccgggagcc actggattcc ctggagctgc tggccgcgtt ggacccccag     2880

gctccaatgg caaccctgga ccccctggtc cccctggtcc ttctggaaaa gatggtccca     2940

aaggtgctcg aggagacagc ggcccccctg gccgagctgg tgaacccggc ctccaaggtc     3000

ctgctggacc ccctggcgag aagggagagc ctggagatga cggtccctct ggtgccgaag     3060

gtccaccagg tccccagggt ctggctggtc agagaggcat cgtcggtctg cctgggcaac     3120

gtggtgagag aggattccct ggcttgcctg gcccgtcggg tgagcccggc aagcagggtg     3180

ctcctggagc atctggagac agaggtcctc ctggccccgt gggtcctcct ggcctgacgg     3240

gtcctgcagg tgaacctgga cgagagggaa gccccggtgc tgatggcccc cctggcagag     3300

atggcgctgc tggagtcaag ggtgatcgtg gtgagactgg tgctgtggga gctcctggag     3360

cccctgggcc ccctggctcc cctggccccg ctggtccaac tggcaagcaa ggagacagag     3420

gagaagctgg tgcacaaggc cccatgggac cctcaggacc agctggagcc cggggaatcc     3480

agggtcctca aggccccaga ggtgacaaag gagaggctgg agagcctggc gagagaggcc     3540

tgaagggaca ccgtggcttc actggtctgc agggtctgcc cggccctcct ggtccttctg     3600

gagaccaagg tgcttctggt cctgctggtc cttctggccc tagaggtcct cctggccccg     3660

tcggtccctc tggcaaagat ggtgctaatg gaatccctgg ccccattggg cctcctggtc     3720

cccgtggacg atcaggcgaa accggccctg ctggtcctcc tggaaatcct ggaccccctg     3780

gtcctccagg tccccctggc cctggcatcg acatgtccgc ctttgctggc ttaggcccga     3840

gagagaaggg ccccgacccc ctgcagtaca tgcgggccga ccaggcagcc ggtggcctga     3900

gacagcatga cgccgaggtg gatgccacac tcaagtccct caacaaccag attgagagca     3960

tccgcagccc cgagggctcc cgcaagaacc ctgctcgcac ctgcagagac ctgaaactct     4020

gccaccctga gtggaagagt ggagactact ggattgaccc caaccaaggc tgcaccttgg     4080

acgccatgaa ggttttctgc aacatggaga ctggcgagac ttgcgtctac cccaatccag     4140

caaacgttcc caagaagaac tggtggagca gcaagagcaa ggagaagaaa cacatctggt     4200

ttggagaaac catcaatggt ggcttccatt tcagctatgg agatgacaat ctggctccca     4260

acactgccaa cgtccagatg accttcctac gcctgctgtc cacggaaggc tcccagaaca     4320

tcacctacca ctgcaagaac agcattgcct atctggacga agcagctggc aacctcaaga     4380

aggccctgct catccagggc tccaatgacg tggagatccg ggcagagggc aatagcaggt     4440

tcacgtacac tgccctgaag gatggctgca cgaaacatac cggtaagtgg ggcaagactg     4500

ttatcgagta ccggtcacag aagacctcac gcctccccat cattgacatt gcacccatgg     4560

acataggagg gcccgagcag gaattcggtg tggacatagg gccggtctgc ttcttgtaaa     4620

aacctgaacc cagaaacaac acaatccgtt gcaaacccaa aggacccaag tactttccaa     4680

tctcagtcac tctaggactc tgcactgaat ggctgacctg acctgatgtc cattcatccc     4740

accctctcac agttcggact tttctcccct ctctttctaa gagacctgaa ctgggcagac     4800

tgcaaaataa aatctcggtg ttctatttat ttattgtctt cctgtaagac cttcgggtca     4860

aggcagaggc aggaaactaa ctggtgtgag tcaaatgccc cctgagtgac tgcccccagc     4920

ccaggccaga agacctccct tcaggtgccg ggcgcaggaa ctgtgtgtgt cctacacaat     4980

ggtgctattc tgtgtcaaac acctctgtat tttttaaaac atcaattgat attaaaaatg     5040

aaaagattat tggaaagta                                                  5059


