                               SEQUENCE LISTING

<110> THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR 
      UNIVERSITY
      U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS 
      AFFAIRS

<120> METHODS FOR PROTEOME LABELING

<130> 079445-001810PC-1138068

<140> PCT/US2019/031587
<141> 2019-05-09

<150> 62/669,907
<151> 2018-05-10

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 1194
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atgtcctcag ctgccaccgt tgatccaaat gaagcttttg ggttgataac aaaaaacctc       60

caagaagtgt tgaaccctca gatcatcaag gatgtccttg aagtacaaaa aaggcatttg      120

aagctcgggt ggggaactgc ccctaccggg cgcccacatt gtgggtattt cgtccctatg      180

actaagttgg ctgatttctt gaaggcaggc tgcgaggtga ctgtgctcct ggccgacttg      240

cacgcctttt tggataatat gaaggcccct ctcgaggtcg tcaattatcg agccaagtac      300

tacgaactca ccattaaagc aatcttgagg agtataaacg tccctataga aaaacttaaa      360

tttgttgtag gttcttcata tcaactgaca cccgattata ccatggacat ttttagactg      420

agcaacattg tgtcccaaaa cgatgctaaa agagcaggag ctgacgttgt gaaacaagtt      480

gcaaacccac ttctttcagg cctgatatat cctcttatgc aagcactcga cgaacaattc      540

cttgatgtcg attgccagtt cggaggtgta gaccagcgaa aaatctttgt tttggccgaa      600

gagaacctgc cctctctggg ctataaaaaa cgggctcact tgatgaatcc aatggtcccc      660

ggattggccc aaggtggcaa aatgtctgca tcagacccca actctaaaat agatctgctg      720

gaggaaccaa agcaagttaa gaagaaaatt aactccgcct tttgcagtcc tggcaatgtc      780

gaggaaaacg ggcttctgtc attcgtgcag tatgtgatcg ccccaattca agaactcaag      840

ttcggtacaa atcattttga gttttttata gatcgaccag aaaaatttgg gggacctatt      900

acatacaaga gttttgaaga gatgaaattg gccttcaaag aagagaagct gagcccacct      960

gatctgaaga tcggagtggc cgacgccatc aatgagttgc ttgaaccaat acgacaggaa     1020

tttgctgata acaaagagtt tcaggaagct agtgaaaagg gctatcccgt agcaacccca     1080

caaaaatcta aaaaagcaaa aaaacctaag aataagggta ctaaataccc tggggctacc     1140

aagactaatg aaattgctac taagctggag gagactaaat tgtaatgatg ataa           1194


<210> 2
<211> 1533
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atggcagaca accctgttct cgaactgctc ttgcggcggt tggaagtagc agatggaggt       60

ttggattcag cagaacttgc cacccaactt ggcgttgaac atcaggccgt cgttggggca      120

gtgaagagtc tgcaagcact cggggaggtg atagaggctg agcttagaag tacaaaatgc      180

tgggagttga ccaccgaggg tgaagagatt gctagagaag ggagtcacga ggcacgcgtt      240

tttcggagta tacctcttga aggacttgtg cagtcagaat tgatgcacct tccctcaggt      300

aaggttggat ttagtaaagc catgagtaat aaatggataa gagttgataa atcagccgcc      360

gacgggccaa gggtgtttag agtcgtcgat tctatagagg atgaagtaca gaaaagactc      420

caactggttc aggctggaca agcagaaaag ctcgcagaaa aagaacggaa tgaattgaga      480

aaacgcaaac tgctgaccga agtgattttg aaaacatatt gggtttcaaa ggggaaagca      540

ttttccacat cagtgtctaa gcaagaagcc gagctctccc ctgaaatgat ttctagcgga      600

agttggcggg accgaccatt caaaccttat aatttcagcg caaggggagt ccttccagat      660

tcaggccacc tccaccctct tcttaaagtc cgctcccagt tccggcagat ctttctggag      720

atggggttca cagaaatgcc tactgacaat tttattgagt ctagcttttg gaatttcgac      780

gcactcttcc agccccaaca gcaccccgca agagaccaac acgacacatt ttttctcagg      840

gatcctgctg aagctctcca attgccaatg ggatacgttc agagggtgaa gagaactcat      900

tcacaaggag gatatggttc tcagggatat aagtacacct ggaagttgga agaggctagg      960

aaaaatctct tgcggactca cactacagcc gcctccgctc gcgctctgta tcagctcgca     1020

caaaaaaagc ctttcacccc agcaaaatat ttctccattg atcgcgtctt ccgaaatgaa     1080

acattggatg ccacacattt ggctgagttc caccaaatag aaggggtcat cgccgaccac     1140

ggtttgactc ttggtcattt gatgggcgta ttgcgcgaat ttttcaccaa actggggatt     1200

acacagctcc gatttaaacc cgcatacaac ccttacgggg agccaagtat ggaagtgttt     1260

agctatcacc aggggctcaa gaagtgggtt gaagtgggaa attcaggagt ctttaggccc     1320

gagatgcttc ttccaatggg cctgccagaa aacgtgtcag taattgcatg gggtctctcc     1380

ctcgagagac ccacaatgat aaagtacgga attaataaca tacgcgagtt ggttgggcac     1440

aaggtaaacc ttcagatggt ctatgactca cccgtctgta gacttgatat agagcctcga     1500

tccagcaaaa cacaggaggc tgcctgatga taa                                  1533


<210> 3
<211> 1527
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atggccgatg ggcaagtggc agagttgctc ctccggagac tcgaggctag tgacggagga       60

ctcgacagcg ctgagctcgc tgccgaactg gggatggagc accaagccgt ggtcggggct      120

gtcaagagct tgcaggcttt gggtgaagtc atcgaggctg aactcaggag caccaaacac      180

tgggaactca cagcagaagg ggaagagata gctagggaag gtagccacga ggctcgggtt      240

tttcgctcca ttccacccga gggacttgct cagtcagaac tcatgcggct tccaagtgga      300

aaagtaggat ttagcaaagc tatgagtaac aagtggatac gagtcgataa aagcgctgcc      360

gacggcccac gcgtattccg ggtggtggat agcatggaag atgaagtgca gcggaggctt      420

cagttggttc gcggagggca ggcagagaaa cttggtgaga aagagcgctc agaacttcgg      480

aagaggaagc tgctggccga agttaccctg aaaacttatt gggtgagtaa aggctccgcc      540

ttcagtacct ccatttccaa gcaggaaacc gagttgtctc cagagatgat tagttctgga      600

agttggcgcg acaggccatt caagccctac aactttctcg cacacggtgt gcttcccgat      660

tcaggtcatc tgcaccctct cctcaaagtt agatcacagt tccgccaaat ctttctggag      720

atggggttca ccgaaatgcc tacagataac ttcatcgaat ccagcttctg gaattttgac      780

gcactgtttc agccccaaca acaccccgcc agagatcagc acgacacatt cttcctgcga      840

gacccagccg aggctcttca gcttccaatg gattatgtgc agcgcgtaaa aagaactcat      900

agtcaaggcg ggtacggaag ccagggttat aagtacaatt ggaaactgga tgaagcaagg      960

aagaatctcc tccgcacaca tactacaagt gcatcagcca gagccctcta tcggctcgcc     1020

caaaagaagc cttttacccc agtgaagtat tttagcatcg accgggtgtt ccgcaacgag     1080

acactggatg ccactcacct ggctgaattt caccagatcg aaggagtggt cgccgaccac     1140

gggttgacac tgggtcattt gatgggggtg ctgcgagaat tttttactaa gctgggcatt     1200

acccaactcc gattcaaacc agcttataac ccctatggag aaccatcaat ggaagtcttc     1260

agttaccatc aaggcctcaa aaagtgggtt gaagtcggca attccggcgt ctttcgacct     1320

gaaatgctgc tccccatggg gcttcctgaa aacgttagtg taatagcctg ggggttgtct     1380

cttgaaaggc ctacaatgat aaaatacggg attaataata tcagggagct ggttggccat     1440

aaagtaaact tgcagatggt ttacgatagc cccctttgca ggctcgacgc cgaaccacgg     1500

cccccaccca cacaggaagc agcatga                                         1527


<210> 4
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ser Ser Ala Ala Thr Val Asp Pro Asn Glu Ala Phe Gly Leu Ile 
1               5                   10                  15      


Thr Lys Asn Leu Gln Glu Val Leu Asn Pro Gln Ile Ile Lys Asp Val 
            20                  25                  30          


Leu Glu Val Gln Lys Arg His Leu Lys Leu Gly Trp Gly Thr Ala Pro 
        35                  40                  45              


Thr Gly Arg Pro His Cys Gly Tyr Phe Val Pro Met Thr Lys Leu Ala 
    50                  55                  60                  


Asp Phe Leu Lys Ala Gly Cys Glu Val Thr Val Leu Leu Ala Asp Leu 
65                  70                  75                  80  


His Ala Phe Leu Asp Asn Met Lys Ala Pro Leu Glu Val Val Asn Tyr 
                85                  90                  95      


Arg Ala Lys Tyr Tyr Glu Leu Thr Ile Lys Ala Ile Leu Arg Ser Ile 
            100                 105                 110         


Asn Val Pro Ile Glu Lys Leu Lys Phe Val Val Gly Ser Ser Tyr Gln 
        115                 120                 125             


Leu Thr Pro Asp Tyr Thr Met Asp Ile Phe Arg Leu Ser Asn Ile Val 
    130                 135                 140                 


Ser Gln Asn Asp Ala Lys Arg Ala Gly Ala Asp Val Val Lys Gln Val 
145                 150                 155                 160 


Ala Asn Pro Leu Leu Ser Gly Leu Ile Tyr Pro Leu Met Gln Ala Leu 
                165                 170                 175     


Asp Glu Gln Phe Leu Asp Val Asp Cys Gln Phe Gly Gly Val Asp Gln 
            180                 185                 190         


Arg Lys Ile Phe Val Leu Ala Glu Glu Asn Leu Pro Ser Leu Gly Tyr 
        195                 200                 205             


Lys Lys Arg Ala His Leu Met Asn Pro Met Val Pro Gly Leu Ala Gln 
    210                 215                 220                 


Gly Gly Lys Met Ser Ala Ser Asp Pro Asn Ser Lys Ile Asp Leu Leu 
225                 230                 235                 240 


Glu Glu Pro Lys Gln Val Lys Lys Lys Ile Asn Ser Ala Phe Cys Ser 
                245                 250                 255     


Pro Gly Asn Val Glu Glu Asn Gly Leu Leu Ser Phe Val Gln Tyr Val 
            260                 265                 270         


Ile Ala Pro Ile Gln Glu Leu Lys Phe Gly Thr Asn His Phe Glu Phe 
        275                 280                 285             


Phe Ile Asp Arg Pro Glu Lys Phe Gly Gly Pro Ile Thr Tyr Lys Ser 
    290                 295                 300                 


Phe Glu Glu Met Lys Leu Ala Phe Lys Glu Glu Lys Leu Ser Pro Pro 
305                 310                 315                 320 


Asp Leu Lys Ile Gly Val Ala Asp Ala Ile Asn Glu Leu Leu Glu Pro 
                325                 330                 335     


Ile Arg Gln Glu Phe Ala Asp Asn Lys Glu Phe Gln Glu Ala Ser Glu 
            340                 345                 350         


Lys Gly Tyr Pro Val Ala Thr Pro Gln Lys Ser Lys Lys Ala Lys Lys 
        355                 360                 365             


Pro Lys Asn Lys Gly Thr Lys Tyr Pro Gly Ala Thr Lys Thr Asn Glu 
    370                 375                 380                 


Ile Ala Thr Lys Leu Glu Glu Thr Lys Leu 
385                 390                 


<210> 5
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Ala Asp Asn Pro Val Leu Glu Leu Leu Leu Arg Arg Leu Glu Val 
1               5                   10                  15      


Ala Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Thr Gln Leu Gly Val 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys Cys Trp Glu Leu Thr 
    50                  55                  60                  


Thr Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Leu Glu Gly Leu Val Gln Ser Glu Leu Met His 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Ile Glu Asp Glu Val Gln Lys Arg Leu Gln Leu Val Gln 
    130                 135                 140                 


Ala Gly Gln Ala Glu Lys Leu Ala Glu Lys Glu Arg Asn Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Thr Glu Val Ile Leu Lys Thr Tyr Trp Val Ser 
                165                 170                 175     


Lys Gly Lys Ala Phe Ser Thr Ser Val Ser Lys Gln Glu Ala Glu Leu 
            180                 185                 190         


Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys 
        195                 200                 205             


Pro Tyr Asn Phe Ser Ala Arg Gly Val Leu Pro Asp Ser Gly His Leu 
    210                 215                 220                 


His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu 
225                 230                 235                 240 


Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe 
                245                 250                 255     


Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp 
            260                 265                 270         


Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu 
        275                 280                 285             


Pro Met Gly Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Tyr Lys Tyr Thr Trp Lys Leu Glu Glu Ala Arg 
305                 310                 315                 320 


Lys Asn Leu Leu Arg Thr His Thr Thr Ala Ala Ser Ala Arg Ala Leu 
                325                 330                 335     


Tyr Gln Leu Ala Gln Lys Lys Pro Phe Thr Pro Ala Lys Tyr Phe Ser 
            340                 345                 350         


Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala 
        355                 360                 365             


Glu Phe His Gln Ile Glu Gly Val Ile Ala Asp His Gly Leu Thr Leu 
    370                 375                 380                 


Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile 
385                 390                 395                 400 


Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Gly Glu Pro Ser 
                405                 410                 415     


Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val 
            420                 425                 430         


Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu 
        435                 440                 445             


Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro 
    450                 455                 460                 


Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His 
465                 470                 475                 480 


Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Val Cys Arg Leu Asp 
                485                 490                 495     


Ile Glu Pro Arg Ser Ser Lys Thr Gln Glu Ala Ala 
            500                 505             


<210> 6
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Asp Gly Gln Val Ala Glu Leu Leu Leu Arg Arg Leu Glu Ala 
1               5                   10                  15      


Ser Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Ala Glu Leu Gly Met 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys His Trp Glu Leu Thr 
    50                  55                  60                  


Ala Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Pro Glu Gly Leu Ala Gln Ser Glu Leu Met Arg 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Met Glu Asp Glu Val Gln Arg Arg Leu Gln Leu Val Arg 
    130                 135                 140                 


Gly Gly Gln Ala Glu Lys Leu Gly Glu Lys Glu Arg Ser Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Ala Glu Val Thr Leu Lys Thr Tyr Trp Val Ser 
                165                 170                 175     


Lys Gly Ser Ala Phe Ser Thr Ser Ile Ser Lys Gln Glu Thr Glu Leu 
            180                 185                 190         


Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Ala His Gly Val Leu Pro Asp Ser Gly His Leu 
    210                 215                 220                 


His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu 
225                 230                 235                 240 


Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe 
                245                 250                 255     


Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp 
            260                 265                 270         


Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu 
        275                 280                 285             


Pro Met Asp Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Tyr Lys Tyr Asn Trp Lys Leu Asp Glu Ala Arg 
305                 310                 315                 320 


Lys Asn Leu Leu Arg Thr His Thr Thr Ser Ala Ser Ala Arg Ala Leu 
                325                 330                 335     


Tyr Arg Leu Ala Gln Lys Lys Pro Phe Thr Pro Val Lys Tyr Phe Ser 
            340                 345                 350         


Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala 
        355                 360                 365             


Glu Phe His Gln Ile Glu Gly Val Val Ala Asp His Gly Leu Thr Leu 
    370                 375                 380                 


Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile 
385                 390                 395                 400 


Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Gly Glu Pro Ser 
                405                 410                 415     


Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val 
            420                 425                 430         


Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu 
        435                 440                 445             


Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro 
    450                 455                 460                 


Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His 
465                 470                 475                 480 


Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Leu Cys Arg Leu Asp 
                485                 490                 495     


Ala Glu Pro Arg Pro Pro Pro Thr Gln Glu Ala Ala 
            500                 505             


<210> 7
<211> 394
<212> PRT
<213> Saccharomyces cerevisiae 

<400> 7
Met Ser Ser Ala Ala Thr Val Asp Pro Asn Glu Ala Phe Gly Leu Ile 
1               5                   10                  15      


Thr Lys Asn Leu Gln Glu Val Leu Asn Pro Gln Ile Ile Lys Asp Val 
            20                  25                  30          


Leu Glu Val Gln Lys Arg His Leu Lys Leu Tyr Trp Gly Thr Ala Pro 
        35                  40                  45              


Thr Gly Arg Pro His Cys Gly Tyr Phe Val Pro Met Thr Lys Leu Ala 
    50                  55                  60                  


Asp Phe Leu Lys Ala Gly Cys Glu Val Thr Val Leu Leu Ala Asp Leu 
65                  70                  75                  80  


His Ala Phe Leu Asp Asn Met Lys Ala Pro Leu Glu Val Val Asn Tyr 
                85                  90                  95      


Arg Ala Lys Tyr Tyr Glu Leu Thr Ile Lys Ala Ile Leu Arg Ser Ile 
            100                 105                 110         


Asn Val Pro Ile Glu Lys Leu Lys Phe Val Val Gly Ser Ser Tyr Gln 
        115                 120                 125             


Leu Thr Pro Asp Tyr Thr Met Asp Ile Phe Arg Leu Ser Asn Ile Val 
    130                 135                 140                 


Ser Gln Asn Asp Ala Lys Arg Ala Gly Ala Asp Val Val Lys Gln Val 
145                 150                 155                 160 


Ala Asn Pro Leu Leu Ser Gly Leu Ile Tyr Pro Leu Met Gln Ala Leu 
                165                 170                 175     


Asp Glu Gln Phe Leu Asp Val Asp Cys Gln Phe Gly Gly Val Asp Gln 
            180                 185                 190         


Arg Lys Ile Phe Val Leu Ala Glu Glu Asn Leu Pro Ser Leu Gly Tyr 
        195                 200                 205             


Lys Lys Arg Ala His Leu Met Asn Pro Met Val Pro Gly Leu Ala Gln 
    210                 215                 220                 


Gly Gly Lys Met Ser Ala Ser Asp Pro Asn Ser Lys Ile Asp Leu Leu 
225                 230                 235                 240 


Glu Glu Pro Lys Gln Val Lys Lys Lys Ile Asn Ser Ala Phe Cys Ser 
                245                 250                 255     


Pro Gly Asn Val Glu Glu Asn Gly Leu Leu Ser Phe Val Gln Tyr Val 
            260                 265                 270         


Ile Ala Pro Ile Gln Glu Leu Lys Phe Gly Thr Asn His Phe Glu Phe 
        275                 280                 285             


Phe Ile Asp Arg Pro Glu Lys Phe Gly Gly Pro Ile Thr Tyr Lys Ser 
    290                 295                 300                 


Phe Glu Glu Met Lys Leu Ala Phe Lys Glu Glu Lys Leu Ser Pro Pro 
305                 310                 315                 320 


Asp Leu Lys Ile Gly Val Ala Asp Ala Ile Asn Glu Leu Leu Glu Pro 
                325                 330                 335     


Ile Arg Gln Glu Phe Ala Asp Asn Lys Glu Phe Gln Glu Ala Ser Glu 
            340                 345                 350         


Lys Gly Tyr Pro Val Ala Thr Pro Gln Lys Ser Lys Lys Ala Lys Lys 
        355                 360                 365             


Pro Lys Asn Lys Gly Thr Lys Tyr Pro Gly Ala Thr Lys Thr Asn Glu 
    370                 375                 380                 


Ile Ala Thr Lys Leu Glu Glu Thr Lys Leu 
385                 390                 


<210> 8
<211> 508
<212> PRT
<213> Mus musculus

<400> 8
Met Ala Asp Asn Pro Val Leu Glu Leu Leu Leu Arg Arg Leu Glu Val 
1               5                   10                  15      


Ala Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Thr Gln Leu Gly Val 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys Cys Trp Glu Leu Thr 
    50                  55                  60                  


Thr Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Leu Glu Gly Leu Val Gln Ser Glu Leu Met His 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Ile Glu Asp Glu Val Gln Lys Arg Leu Gln Leu Val Gln 
    130                 135                 140                 


Ala Gly Gln Ala Glu Lys Leu Ala Glu Lys Glu Arg Asn Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Thr Glu Val Ile Leu Lys Thr Tyr Trp Val Ser 
                165                 170                 175     


Lys Gly Lys Ala Phe Ser Thr Ser Val Ser Lys Gln Glu Ala Glu Leu 
            180                 185                 190         


Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys 
        195                 200                 205             


Pro Tyr Asn Phe Ser Ala Arg Gly Val Leu Pro Asp Ser Gly His Leu 
    210                 215                 220                 


His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu 
225                 230                 235                 240 


Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe 
                245                 250                 255     


Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp 
            260                 265                 270         


Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu 
        275                 280                 285             


Pro Met Gly Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Tyr Lys Tyr Thr Trp Lys Leu Glu Glu Ala Arg 
305                 310                 315                 320 


Lys Asn Leu Leu Arg Thr His Thr Thr Ala Ala Ser Ala Arg Ala Leu 
                325                 330                 335     


Tyr Gln Leu Ala Gln Lys Lys Pro Phe Thr Pro Ala Lys Tyr Phe Ser 
            340                 345                 350         


Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala 
        355                 360                 365             


Glu Phe His Gln Ile Glu Gly Val Ile Ala Asp His Gly Leu Thr Leu 
    370                 375                 380                 


Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile 
385                 390                 395                 400 


Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Thr Glu Pro Ser 
                405                 410                 415     


Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val 
            420                 425                 430         


Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu 
        435                 440                 445             


Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro 
    450                 455                 460                 


Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His 
465                 470                 475                 480 


Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Val Cys Arg Leu Asp 
                485                 490                 495     


Ile Glu Pro Arg Ser Ser Lys Thr Gln Glu Ala Ala 
            500                 505             


<210> 9
<211> 508
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Asp Gly Gln Val Ala Glu Leu Leu Leu Arg Arg Leu Glu Ala 
1               5                   10                  15      


Ser Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Ala Glu Leu Gly Met 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys His Trp Glu Leu Thr 
    50                  55                  60                  


Ala Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Pro Glu Gly Leu Ala Gln Ser Glu Leu Met Arg 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Met Glu Asp Glu Val Gln Arg Arg Leu Gln Leu Val Arg 
    130                 135                 140                 


Gly Gly Gln Ala Glu Lys Leu Gly Glu Lys Glu Arg Ser Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Ala Glu Val Thr Leu Lys Thr Tyr Trp Val Ser 
                165                 170                 175     


Lys Gly Ser Ala Phe Ser Thr Ser Ile Ser Lys Gln Glu Thr Glu Leu 
            180                 185                 190         


Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Ala His Gly Val Leu Pro Asp Ser Gly His Leu 
    210                 215                 220                 


His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu 
225                 230                 235                 240 


Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe 
                245                 250                 255     


Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp 
            260                 265                 270         


Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu 
        275                 280                 285             


Pro Met Asp Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Tyr Lys Tyr Asn Trp Lys Leu Asp Glu Ala Arg 
305                 310                 315                 320 


Lys Asn Leu Leu Arg Thr His Thr Thr Ser Ala Ser Ala Arg Ala Leu 
                325                 330                 335     


Tyr Arg Leu Ala Gln Lys Lys Pro Phe Thr Pro Val Lys Tyr Phe Ser 
            340                 345                 350         


Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala 
        355                 360                 365             


Glu Phe His Gln Ile Glu Gly Val Val Ala Asp His Gly Leu Thr Leu 
    370                 375                 380                 


Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile 
385                 390                 395                 400 


Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Thr Glu Pro Ser 
                405                 410                 415     


Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val 
            420                 425                 430         


Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu 
        435                 440                 445             


Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro 
    450                 455                 460                 


Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His 
465                 470                 475                 480 


Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Leu Cys Arg Leu Asp 
                485                 490                 495     


Ala Glu Pro Arg Pro Pro Pro Thr Gln Glu Ala Ala 
            500                 505             


<210> 10
<211> 1527
<212> DNA
<213> Homo sapiens

<400> 10
atggccgatg ggcaagtggc agagttgctc ctccggagac tcgaggctag tgacggagga       60

ctcgacagcg ctgagctcgc tgccgaactg gggatggagc accaagccgt ggtcggggct      120

gtcaagagct tgcaggcttt gggtgaagtc atcgaggctg aactcaggag caccaaacac      180

tgggaactca cagcagaagg ggaagagata gctagggaag gtagccacga ggctcgggtt      240

tttcgctcca ttccacccga gggacttgct cagtcagaac tcatgcggct tccaagtgga      300

aaagtaggat ttagcaaagc tatgagtaac aagtggatac gagtcgataa aagcgctgcc      360

gacggcccac gcgtattccg ggtggtggat agcatggaag atgaagtgca gcggaggctt      420

cagttggttc gcggagggca ggcagagaaa cttggtgaga aagagcgctc agaacttcgg      480

aagaggaagc tgctggccga agttaccctg aaaacttatt gggtgagtaa aggctccgcc      540

ttcagtacct ccatttccaa gcaggaaacc gagttgtctc cagagatgat tagttctgga      600

agttggcgcg acaggccatt caagccctac aactttctcg cacacggtgt gcttcccgat      660

tcaggtcatc tgcaccctct cctcaaagtt agatcacagt tccgccaaat ctttctggag      720

atggggttca ccgaaatgcc tacagataac ttcatcgaat ccagcttctg gaattttgac      780

gcactgtttc agccccaaca acaccccgcc agagatcagc acgacacatt cttcctgcga      840

gacccagccg aggctcttca gcttccaatg gattatgtgc agcgcgtaaa aagaactcat      900

agtcaaggcg ggtacggaag ccagggttat aagtacaatt ggaaactgga tgaagcaagg      960

aagaatctcc tccgcacaca tactacaagt gcatcagcca gagccctcta tcggctcgcc     1020

caaaagaagc cttttacccc agtgaagtat tttagcatcg accgggtgtt ccgcaacgag     1080

acactggatg ccactcacct ggctgaattt caccagatcg aaggagtggt cgccgaccac     1140

gggttgacac tgggtcattt gatgggggtg ctgcgagaat tttttactaa gctgggcatt     1200

acccaactcc gattcaaacc agcttataac ccctatacag aaccatcaat ggaagtcttc     1260

agttaccatc aaggcctcaa aaagtgggtt gaagtcggca attccggcgt ctttcgacct     1320

gaaatgctgc tccccatggg gcttcctgaa aacgttagtg taatagcctg ggggttgtct     1380

cttgaaaggc ctacaatgat aaaatacggg attaataata tcagggagct ggttggccat     1440

aaagtaaact tgcagatggt ttacgatagc cccctttgca ggctcgacgc cgaaccacgg     1500

cccccaccca cacaggaagc agcatga                                         1527


<210> 11
<211> 1527
<212> DNA
<213> Mus musculus

<400> 11
atggcagaca accctgttct cgaactgctc ttgcggcggt tggaagtagc agatggaggt       60

ttggattcag cagaacttgc cacccaactt ggcgttgaac atcaggccgt cgttggggca      120

gtgaagagtc tgcaagcact cggggaggtg atagaggctg agcttagaag tacaaaatgc      180

tgggagttga ccaccgaggg tgaagagatt gctagagaag ggagtcacga ggcacgcgtt      240

tttcggagta tacctcttga aggacttgtg cagtcagaat tgatgcacct tccctcaggt      300

aaggttggat ttagtaaagc catgagtaat aaatggataa gagttgataa atcagccgcc      360

gacgggccaa gggtgtttag agtcgtcgat tctatagagg atgaagtaca gaaaagactc      420

caactggttc aggctggaca agcagaaaag ctcgcagaaa aagaacggaa tgaattgaga      480

aaacgcaaac tgctgaccga agtgattttg aaaacatatt gggtttcaaa ggggaaagca      540

ttttccacat cagtgtctaa gcaagaagcc gagctctccc ctgaaatgat ttctagcgga      600

agttggcggg accgaccatt caaaccttat aatttcagcg caaggggagt ccttccagat      660

tcaggccacc tccaccctct tcttaaagtc cgctcccagt tccggcagat ctttctggag      720

atggggttca cagaaatgcc tactgacaat tttattgagt ctagcttttg gaatttcgac      780

gcactcttcc agccccaaca gcaccccgca agagaccaac acgacacatt ttttctcagg      840

gatcctgctg aagctctcca attgccaatg ggatacgttc agagggtgaa gagaactcat      900

tcacaaggag gatatggttc tcagggatat aagtacacct ggaagttgga agaggctagg      960

aaaaatctct tgcggactca cactacagcc gcctccgctc gcgctctgta tcagctcgca     1020

caaaaaaagc ctttcacccc agcaaaatat ttctccattg atcgcgtctt ccgaaatgaa     1080

acattggatg ccacacattt ggctgagttc caccaaatag aaggggtcat cgccgaccac     1140

ggtttgactc ttggtcattt gatgggcgta ttgcgcgaat ttttcaccaa actggggatt     1200

acacagctcc gatttaaacc cgcatacaac ccttacacag agccaagtat ggaagtgttt     1260

agctatcacc aggggctcaa gaagtgggtt gaagtgggaa attcaggagt ctttaggccc     1320

gagatgcttc ttccaatggg cctgccagaa aacgtgtcag taattgcatg gggtctctcc     1380

ctcgagagac ccacaatgat aaagtacgga attaataaca tacgcgagtt ggttgggcac     1440

aaggtaaacc ttcagatggt ctatgactca cccgtctgta gacttgatat agagcctcga     1500

tccagcaaaa cacaggaggc tgcctga                                         1527


