                         SEQUENCE LISTING

<110>  Proplex Technologies, LLC
       Chang, Frank  N.
       Tuszynski, George  P.
       Luo, Solomon
       Yang, Jeff
 
<120>  BINDING PROTEINS AND CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING 
       GASP-1 GRANULES AND USES THEREOF

<130>  PRX-101WO

<150>  62/670,182
<151>  2018-05-11

<150>  62/768,325
<151>  2018-11-16

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Lys Leu Val Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp His Asn Gly Ser Thr Asp Tyr Asn Ser Ala Leu Arg 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Lys Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Arg Ser Pro Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  2
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  2

Gly Phe Ser Leu Thr Gly Tyr 
1               5           


<210>  3
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  3

Trp His Asn Gly Ser 
1               5   


<210>  4
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Gly Arg Ser Pro Trp Phe Pro Tyr 
1               5                   


<210>  5
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  5
gaggtgaagt tggtggagtc aggacctggc ctggtggcgc cctcacagag cctgaccatc       60

acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggaatg atctggcata atggaagcac agactataat      180

tcagctctca gatccagact gagcatcaac aaggacaagt ccaagaacca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agggggaagg      300

tccccctggt ttccttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  6
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  6
gggttctcat taaccggcta t                                                 21


<210>  7
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  7
tggcataatg gaagc                                                        15


<210>  8
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  8
gggggaaggt ccccctggtt tccttac                                           27


<210>  9
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  9

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Asn Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  10

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Asn Leu Asn 
1               5                   10                  15      


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  13
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  13
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgacga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  14
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  14
aagtcaagtc agagcctctt agatagtgat ggaaagacat atttgaat                    48


<210>  15
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  15
ctggtgtcta aactggactc t                                                 21


<210>  16
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  16
tggcaaggta cacattttcc gtggacg                                           27


<210>  17
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  19
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  19
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacaaa tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgacga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  20
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  20
aagtcaagtc agagcctctt agatagtgat ggaaagacaa atttgaat                    48


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  22
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Glu Ala Ser Pro Glu Ala Val Ala Gly Val Gly Phe Glu Ser Lys 
1               5                   10                  15      


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Trp Lys Glu Asp Glu Ala Ile Ser Glu Ala Thr Asp Arg 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Cys Ser Lys Ser Ser Pro Lys Ala Glu Glu Glu Glu Val 
1               5                   10              


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Glu Glu Ala Ser Ile Gln Ala Gly Ser Gln Ala Val Glu Glu 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Phe Trp Asp Gly Lys Glu Val Ser Glu Glu Ala Gly Pro Cys 
1               5                   10                  


<210>  27
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtga                                                      1335


<210>  28
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  29
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Gly Ala Thr Gly Thr Thr Gly Thr Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Ala Cys Thr Cys Cys Ala Cys Thr Cys Ala Cys Thr Thr Thr 
            20                  25                  30          


Gly Thr Cys Gly Gly Thr Thr Ala Cys Cys Ala Thr Thr Gly Gly Ala 
        35                  40                  45              


Cys Ala Ala Cys Cys Ala Gly Cys Cys Thr Cys Cys Ala Thr Cys Thr 
    50                  55                  60                  


Cys Thr Thr Gly Cys Ala Ala Gly Thr Cys Ala Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Ala Gly Cys Cys Thr Cys Thr Thr Ala Gly Ala Thr Ala Gly Thr 
                85                  90                  95      


Gly Ala Thr Gly Gly Ala Ala Ala Gly Ala Cys Ala Thr Ala Thr Thr 
            100                 105                 110         


Thr Gly Ala Ala Thr Thr Gly Gly Thr Thr Gly Thr Thr Ala Cys Ala 
        115                 120                 125             


Gly Ala Gly Gly Cys Cys Ala Gly Gly Cys Cys Ala Gly Thr Cys Thr 
    130                 135                 140                 


Cys Cys Ala Ala Ala Gly Cys Gly Cys Cys Thr Ala Ala Thr Cys Thr 
145                 150                 155                 160 


Ala Thr Cys Thr Gly Gly Thr Gly Thr Cys Thr Ala Ala Ala Cys Thr 
                165                 170                 175     


Gly Gly Ala Cys Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr 
            180                 185                 190         


Gly Ala Cys Ala Gly Gly Thr Thr Cys Ala Cys Thr Gly Gly Cys Ala 
        195                 200                 205             


Gly Thr Gly Gly Ala Thr Cys Ala Gly Gly Gly Ala Cys Ala Gly Ala 
    210                 215                 220                 


Thr Thr Thr Cys Ala Cys Ala Cys Thr Gly Ala Ala Ala Ala Thr Cys 
225                 230                 235                 240 


Ala Gly Cys Ala Gly Ala Gly Thr Gly Gly Ala Gly Gly Cys Thr Gly 
                245                 250                 255     


Ala Cys Gly Ala Thr Thr Thr Gly Gly Gly Ala Gly Thr Thr Thr Ala 
            260                 265                 270         


Thr Thr Ala Thr Thr Gly Cys Thr Gly Gly Cys Ala Ala Gly Gly Thr 
        275                 280                 285             


Ala Cys Ala Cys Ala Thr Thr Thr Thr Cys Cys Gly Thr Gly Gly Ala 
    290                 295                 300                 


Cys Gly Thr Thr Cys Gly Gly Thr Gly Gly Ala Gly Gly Cys Ala Cys 
305                 310                 315                 320 


Cys Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Ala 
                325                 330                 335     


Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Cys Ala Gly Cys Gly 
            340                 345                 350         


Gly Ala Gly Gly Ala Gly Gly Thr Gly Gly Gly Thr Cys Cys Gly Gly 
        355                 360                 365             


Cys Gly Gly Thr Gly Gly Ala Gly Gly Ala Ala Gly Cys Gly Ala Gly 
    370                 375                 380                 


Gly Thr Gly Ala Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
385                 390                 395                 400 


Cys Ala Gly Gly Ala Cys Cys Thr Gly Gly Cys Cys Thr Gly Gly Thr 
                405                 410                 415     


Gly Gly Cys Gly Cys Cys Cys Thr Cys Ala Cys Ala Gly Ala Gly Cys 
            420                 425                 430         


Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Ala Thr Gly Cys Ala 
        435                 440                 445             


Cys Cys Gly Thr Cys Thr Cys Ala Gly Gly Gly Thr Thr Cys Thr Cys 
    450                 455                 460                 


Ala Thr Thr Ala Ala Cys Cys Gly Gly Cys Thr Ala Thr Gly Gly Thr 
465                 470                 475                 480 


Gly Thr Ala Ala Ala Cys Thr Gly Gly Gly Thr Thr Cys Gly Cys Cys 
                485                 490                 495     


Ala Gly Cys Cys Thr Cys Cys Ala Gly Gly Ala Ala Ala Gly Gly Gly 
            500                 505                 510         


Thr Cys Thr Gly Gly Ala Gly Thr Gly Gly Cys Thr Gly Gly Gly Ala 
        515                 520                 525             


Ala Thr Gly Ala Thr Cys Thr Gly Gly Cys Ala Thr Ala Ala Thr Gly 
    530                 535                 540                 


Gly Ala Ala Gly Cys Ala Cys Ala Gly Ala Cys Thr Ala Thr Ala Ala 
545                 550                 555                 560 


Thr Thr Cys Ala Gly Cys Thr Cys Thr Cys Ala Gly Ala Thr Cys Cys 
                565                 570                 575     


Ala Gly Ala Cys Thr Gly Ala Gly Cys Ala Thr Cys Ala Ala Cys Ala 
            580                 585                 590         


Ala Gly Gly Ala Cys Ala Ala Gly Thr Cys Cys Ala Ala Gly Ala Ala 
        595                 600                 605             


Cys Cys Ala Ala Gly Thr Thr Thr Thr Cys Thr Thr Ala Ala Ala Ala 
    610                 615                 620                 


Ala Thr Gly Ala Ala Cys Ala Gly Thr Cys Thr Gly Cys Ala Ala Ala 
625                 630                 635                 640 


Cys Thr Gly Ala Thr Gly Ala Cys Ala Cys Ala Gly Cys Cys Ala Gly 
                645                 650                 655     


Gly Thr Ala Cys Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Ala 
            660                 665                 670         


Gly Gly Gly Gly Gly Ala Ala Gly Gly Thr Cys Cys Cys Cys Cys Thr 
        675                 680                 685             


Gly Gly Thr Thr Thr Cys Cys Thr Thr Ala Cys Thr Gly Gly Gly Gly 
    690                 695                 700                 


Cys Cys Ala Ala Gly Gly Gly Ala Cys Thr Cys Thr Gly Gly Thr Cys 
705                 710                 715                 720 


Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly Cys Ala Ala Gly Ala Thr 
                725                 730                 735     


Cys Thr 
        


<210>  30
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Cys Cys Ala Cys Gly Ala Cys Gly Cys Cys Ala Gly Cys Gly Cys Cys 
1               5                   10                  15      


Gly Cys Gly Ala Cys Cys Ala Cys Cys Ala Ala Cys Ala Cys Cys Gly 
            20                  25                  30          


Gly Cys Gly Cys Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Gly Thr 
        35                  40                  45              


Cys Gly Cys Ala Gly Cys Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr 
    50                  55                  60                  


Gly Cys Gly Cys Cys Cys Ala Gly Ala Gly Gly Cys Gly Thr Gly Cys 
65                  70                  75                  80  


Cys Gly Gly Cys Cys Ala Gly Cys Gly Gly Cys Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Cys Gly Cys Ala Gly Thr Gly Cys Ala Cys Ala Cys Gly Ala Gly 
            100                 105                 110         


Gly Gly Gly Gly Cys Thr Gly Gly Ala Cys Thr Thr Cys Gly Cys Cys 
        115                 120                 125             


Thr Gly Thr Gly Ala Thr Ala 
    130                 135 


<210>  31
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt gaggagcaag cggagcagac tgctgcacag cgactacatg      120

aacatgaccc cccggaggcc tggccccacc cggaagcact accagcccta cgcccctccc      180

agggatttcg ccgcctaccg gagc                                             204


<210>  32
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  33
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
gagggcagag gcagcctgct gacatgtggc gacgtggaag agaaccctgg cccc             54


<210>  34
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tcgcaaagtg       60

tgtaacggaa taggtattgg tgaatttaaa gactcactct ccataaatgc tacgaatatt      120

aaacacttca aaaactgcac ctccatcagt ggcgatctcc acatcctgcc ggtggcattt      180

aggggtgact ccttcacaca tactcctcct ctggatccac aggaactgga tattctgaaa      240

accgtaaagg aaatcacagg gtttttgctg attcaggctt ggcctgaaaa caggacggac      300

ctccatgcct ttgagaacct agaaatcata cgcggcagga ccaagcaaca tggtcagttt      360

tctcttgcag tcgtcagcct gaacataaca tccttgggat tacgctccct caaggagata      420

agtgatggag atgtgataat ttcaggaaac aaaaatttgt gctatgcaaa tacaataaac      480

tggaaaaaac tgtttgggac ctccggtcag aaaaccaaaa ttataagcaa cagaggtgaa      540

aacagctgca aggccacagg ccaggtctgc catgccttgt gctcccccga gggctgctgg      600

ggcccggagc ccagggactg cgtctcttgc cggaatgtca gccgaggcag ggaatgcgtg      660

gacaagtgca accttctgga gggtgagcca agggagtttg tggagaactc tgagtgcata      720

cagtgccacc cagagtgcct gcctcaggcc atgaacatca cctgcacagg acggggacca      780

gacaactgta tccagtgtgc ccactacatt gacggccccc actgcgtcaa gacctgcccg      840

gcaggagtca tgggagaaaa caacaccctg gtctggaagt acgcagacgc cggccatgtg      900

tgccacctgt gccatccaaa ctgcacctac ggatgcactg ggccaggtct tgaaggctgt      960

ccaacgaatg ggcctaagat cccgtccatc gccactggga tggtgggggc cctcctcttg     1020

ctgctggtgg tggccctggg gatcggcctc ttcatg                               1056


<210>  35
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  36
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Asn Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Lys Leu Val Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
    130                 135                 140                 


Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly 
145                 150                 155                 160 


Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
                165                 170                 175     


Met Ile Trp His Asn Gly Ser Thr Asp Tyr Asn Ser Ala Leu Arg Ser 
            180                 185                 190         


Arg Leu Ser Ile Asn Lys Asp Lys Ser Lys Asn Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Gly Gly Arg Ser Pro Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ala 
                


<210>  37
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        35                  40                  


<210>  38
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  39
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  41
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
            20                  25                  30          


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
        35                  40                  45              


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
    50                  55                  60                  


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
65                  70                  75                  80  


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
                85                  90                  95      


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
            100                 105                 110         


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
        115                 120                 125             


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
    130                 135                 140                 


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
145                 150                 155                 160 


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
                165                 170                 175     


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
            180                 185                 190         


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
        195                 200                 205             


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
    210                 215                 220                 


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
225                 230                 235                 240 


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
                245                 250                 255     


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
            260                 265                 270         


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
        275                 280                 285             


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
    290                 295                 300                 


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
305                 310                 315                 320 


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
                325                 330                 335     


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
            340                 345                 350         


<210>  42
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacaaa tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgacga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaaggtg gaggtggcag cggaggaggt      360

gggtccggcg gtggaggaag cgaggtgaag ttggtggagt caggacctgg cctggtggcg      420

ccctcacaga gcctgaccat cacatgcacc gtctcagggt tctcattaac cggctatggt      480

gtaaactggg ttcgccagcc tccaggaaag ggtctggagt ggctgggaat gatctggcat      540

aatggaagca cagactataa ttcagctctc agatccagac tgagcatcaa caaggacaag      600

tccaagaacc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccaggtac      660

tactgtgcca gagggggaag gtccccctgg tttccttact ggggccaagg gactctggtc      720

actgtctctg caagatct                                                    738


<210>  43
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Lys Leu Val Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
    130                 135                 140                 


Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly 
145                 150                 155                 160 


Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
                165                 170                 175     


Met Ile Trp His Asn Gly Ser Thr Asp Tyr Asn Ser Ala Leu Arg Ser 
            180                 185                 190         


Arg Leu Ser Ile Asn Lys Asp Lys Ser Lys Asn Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Gly Gly Arg Ser Pro Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ala 
                


<210>  44
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Glu Val Lys Leu Val Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp His Asn Gly Ser Thr Asp Tyr Asn Ser Ala Leu Arg 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Lys Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Arg Ser Pro Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  45
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  46
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Asn Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  48
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


