                         SEQUENCE LISTING

<110>  The University of Chicago
       Anokion SA
 
<120>  COMPOSITIONS AND METHODS CONCERNING IMMUNE TOLERANCE

<130>  ARCD.P0659WO

<150>  62/669044
<151>  2018-05-09

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  2
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly 
1               5                   10                  15      


Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val 
            20                  25                  30          


Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu 
        35                  40                  45              


Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro 
    50                  55                  60                  


Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys 
65                  70                  75                  80  


Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp 
                85                  90                  95      


Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln 
            100                 105                 110         


Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg 
        115                 120                 125             


Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu 
    130                 135                 140                 


Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu 
145                 150                 155                 160 


Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro 
                165                 170                 175     


Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala 
            180                 185                 190         


Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu 
        195                 200                 205             


Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met 
    210                 215                 220                 


Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser 
225                 230                 235                 240 


Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe 
                245                 250                 255     


Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg 
            260                 265                 270         


Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly 
        275                 280                 285             


Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys 
    290                 295                 300                 


Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu 
305                 310                 315                 320 


Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala 
                325                 330                 335     


Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 
            340                 345                 350         


Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly 
        355                 360                 365             


Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val 
    370                 375                 380                 


Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val 
385                 390                 395                 400 


Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln 
                405                 410                 415     


Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His 
            420                 425                 430         


Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg 
        435                 440                 445             


His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr 
    450                 455                 460                 


Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr 
465                 470                 475                 480 


Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp 
                485                 490                 495     


Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser 
            500                 505                 510         


Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys 
        515                 520                 525             


Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met 
    530                 535                 540                 


Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 
545                 550                 555                 560 


Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu 
                565                 570                 575     


Glu Ile Glu Arg Leu Gly Gln Asp Leu 
            580                 585 


<210>  3
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg Leu Thr Trp Ser Phe Leu Trp Ser Val Phe Trp Leu Ile 
145                 150                 155                 160 


Gln Ile Ser Val Cys Ile Ser Arg Val Phe Ile Ala Thr His Phe Pro 
                165                 170                 175     


His Gln Val Ile Leu Gly Val Ile Gly Gly Met Leu Val Ala Glu Ala 
            180                 185                 190         


Phe Glu His Thr Pro Gly Ile Gln Thr Ala Ser Leu Gly Thr Tyr Leu 
        195                 200                 205             


Lys Thr Asn Leu Phe Leu Phe Leu Phe Ala Val Gly Phe Tyr Leu Leu 
    210                 215                 220                 


Leu Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile Ala Lys 
225                 230                 235                 240 


Lys Trp Cys Ala Asn Pro Asp Trp Ile His Ile Asp Thr Thr Pro Phe 
                245                 250                 255     


Ala Gly Leu Val Arg Asn Leu Gly Val Leu Phe Gly Leu Gly Phe Ala 
            260                 265                 270         


Ile Asn Ser Glu Met Phe Leu Leu Ser Cys Arg Gly Gly Asn Asn Tyr 
        275                 280                 285             


Thr Leu Ser Phe Arg Leu Leu Cys Ala Leu Thr Ser Leu Thr Ile Leu 
    290                 295                 300                 


Gln Leu Tyr His Phe Leu Gln Ile Pro Thr His Glu Glu His Leu Phe 
305                 310                 315                 320 


Tyr Val Leu Ser Phe Cys Lys Ser Ala Ser Ile Pro Leu Thr Val Val 
                325                 330                 335     


Ala Phe Ile Pro Tyr Ser Val His Met Leu Met Lys Gln Ser Gly Lys 
            340                 345                 350         


Lys Ser Gln 
        355 


<210>  4
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  5
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln 
65                  70  


<210>  6
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
1               5                   10                  15      


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
            20                  25                  30          


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
        35                  40                  45              


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln 
    50                  55                  60          


<210>  7
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
1               5                   10                  15      


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln 
            20                  25                  30  


<210>  8
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln 
        35              


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   10                  15  


<210>  10
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly 
1               5                   10                  15      


Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys 
            20                  25          


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly 
1               5                   10      


<210>  12
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly 
1               5                   10                  15      


Ile Val 
        


<210>  13
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly 
1               5                   10                  15      


Ser Leu Gln Lys 
            20  


<210>  14
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
1               5                   10                  15      


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp 
            20                  25              


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu 
1               5                   10                  15      


Gln 
    


<210>  16
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Tyr Gln Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly 
1               5                   10                  15      


Asn Ile Lys Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala 
            20                  25                  30          


Arg Ile Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile 
        35                  40                  45              


Asn Ala Ser Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile 
    50                  55                  60                  


Ala 
65  


<210>  17
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
1               5                   10                  15      


Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
            20                  25                  30          


Val Lys Gln 
        35  


<210>  18
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Ala Ser Leu Tyr His Val Tyr Glu Val Asn Leu Val Ser Glu His 
1               5                   10                  15      


Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val 
            20                  25                  30          


Gln Thr Gln Glu Thr Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp 
        35                  40                  45              


Pro Ala Glu Gly Thr Pro Ala Ser 
    50                  55      


<210>  19
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu His Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln 
1               5                   10                  15      


Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu 
            20                  25                  30          


Lys Ala Leu Pro Gln Cys Gly 
        35                  


<210>  20
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210>  21
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  22
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  23
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe 
1               5                   10                  15      


Leu Pro Arg His 
            20  


<210>  24
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Asn Pro Trp His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro 
1               5                   10                  15      


<210>  25
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly 
1               5                   10                  15      


Tyr Gly Gly 
            


<210>  26
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser 
1               5                   10                  15      


Arg Ser Gly Ser Pro Met Ala Arg Arg 
            20                  25  


<210>  27
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Val 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Trp His Leu Tyr 
1               5                   10                  15      


Arg Asn Gly Lys 
            20  


<210>  29
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  29

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile 
1               5                   10                  15      


<210>  30
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  30

Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser 
1               5                   10                  15      


Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu 
            20                  25                  30      


<210>  31
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr 
1               5                   10                  15      


Pro 
    


<210>  32
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15      


Thr 
    


<210>  34
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15      


Thr Pro 
        


<210>  35
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15      


Thr Pro Pro Pro Ser Gln Gly Lys Gly 
            20                  25  


<210>  36
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  36

Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser 
1               5                   10                  15      


Gln Gly Lys Gly 
            20  


<210>  37
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Leu Lys Gly Val Asp Ala 
1               5                   10                  15      


Gln Gly Thr Leu Ser Lys Ile Phe Lys 
            20                  25  


<210>  38
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp 
1               5                   10                  15      


Tyr Glu 
        


<210>  39
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys 
1               5                   10                  15      


Thr Thr 
        


<210>  40
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys 
1               5                   10                  15      


Gly Leu Ser Ala Thr Val 
            20          


<210>  41
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  41

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser 
1               5                   10                  15      


Ala Ser Ile Gly 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met 
1               5                   10                  15      


Tyr Gly Val Leu 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  43

Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile 
1               5                   10                  15      


Ser Pro Gly Lys 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu 
1               5                   10                  15      


Val Gly Trp Tyr 
            20  


<210>  45
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly 
1               5                   10                  15      


Lys Val Thr Leu Arg Ile Arg 
            20              


<210>  46
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala 
    50                  55                  60          


<210>  47
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys 
1               5                   10                  15      


Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg 
            20                  25                  30          


Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro 
        35                  40                  45              


Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Cys Gly 
    50                  55                  60              


<210>  48
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  49
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  50
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  51
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu 
1               5                   10                  15      


Cys Thr Arg Glu Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln 
            20                  25                  30          


Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu Ile Phe 
        35                  40                  45              


Val Leu Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys 
    50                  55                  60                  


Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys Phe Gly Leu Ser 
65                  70                  75                  80  


Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile 
                85                  90                  95      


Asn Pro Ala Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile 
            100                 105                 110         


Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile 
        115                 120                 125             


Gly Ala Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly 
    130                 135                 140                 


Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala Gly His Gly Leu 
145                 150                 155                 160 


Leu Val Glu Leu Ile Ile Thr Phe Gln Leu Val Phe Thr Ile Phe Ala 
                165                 170                 175     


Ser Cys Asp Ser Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala 
            180                 185                 190         


Ile Gly Phe Ser Val Ala Ile Gly His Leu Phe Ala Ile Asn Tyr Thr 
        195                 200                 205             


Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met 
    210                 215                 220                 


Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly 
225                 230                 235                 240 


Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val 
                245                 250                 255     


Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln 
            260                 265                 270         


Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln Val Glu 
        275                 280                 285             


Thr Asp Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val 
    290                 295                 300                 


Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu 
305                 310                 315                 320 


Ser Ser Val 
            


<210>  52
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 
        355                 360                 365             


Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 
    370                 375                 380                 


His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 
385                 390                 395                 400 


Asn Asp Val Asp Glu 
                405 


<210>  53
<211>  1247
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Met Arg Glu Trp Val Leu Leu Met Ser Val Leu Leu Cys Gly Leu 
1               5                   10                  15      


Ala Gly Pro Thr His Leu Phe Gln Pro Ser Leu Val Leu Asp Met Ala 
            20                  25                  30          


Lys Val Leu Leu Asp Asn Tyr Cys Phe Pro Glu Asn Leu Leu Gly Met 
        35                  40                  45              


Gln Glu Ala Ile Gln Gln Ala Ile Lys Ser His Glu Ile Leu Ser Ile 
    50                  55                  60                  


Ser Asp Pro Gln Thr Leu Ala Ser Val Leu Thr Ala Gly Val Gln Ser 
65                  70                  75                  80  


Ser Leu Asn Asp Pro Arg Leu Val Ile Ser Tyr Glu Pro Ser Thr Pro 
                85                  90                  95      


Glu Pro Pro Pro Gln Val Pro Ala Leu Thr Ser Leu Ser Glu Glu Glu 
            100                 105                 110         


Leu Leu Ala Trp Leu Gln Arg Gly Leu Arg His Glu Val Leu Glu Gly 
        115                 120                 125             


Asn Val Gly Tyr Leu Arg Val Asp Ser Val Pro Gly Gln Glu Val Leu 
    130                 135                 140                 


Ser Met Met Gly Glu Phe Leu Val Ala His Val Trp Gly Asn Leu Met 
145                 150                 155                 160 


Gly Thr Ser Ala Leu Val Leu Asp Leu Arg His Cys Thr Gly Gly Gln 
                165                 170                 175     


Val Ser Gly Ile Pro Tyr Ile Ile Ser Tyr Leu His Pro Gly Asn Thr 
            180                 185                 190         


Ile Leu His Val Asp Thr Ile Tyr Asn Arg Pro Ser Asn Thr Thr Thr 
        195                 200                 205             


Glu Ile Trp Thr Leu Pro Gln Val Leu Gly Glu Arg Tyr Gly Ala Asp 
    210                 215                 220                 


Lys Asp Val Val Val Leu Thr Ser Ser Gln Thr Arg Gly Val Ala Glu 
225                 230                 235                 240 


Asp Ile Ala His Ile Leu Lys Gln Met Arg Arg Ala Ile Val Val Gly 
                245                 250                 255     


Glu Arg Thr Gly Gly Gly Ala Leu Asp Leu Arg Lys Leu Arg Ile Gly 
            260                 265                 270         


Glu Ser Asp Phe Phe Phe Thr Val Pro Val Ser Arg Ser Leu Gly Pro 
        275                 280                 285             


Leu Gly Gly Gly Ser Gln Thr Trp Glu Gly Ser Gly Val Leu Pro Cys 
    290                 295                 300                 


Val Gly Thr Pro Ala Glu Gln Ala Leu Glu Lys Ala Leu Ala Ile Leu 
305                 310                 315                 320 


Thr Leu Arg Ser Ala Leu Pro Gly Val Val His Cys Leu Gln Glu Val 
                325                 330                 335     


Leu Lys Asp Tyr Tyr Thr Leu Val Asp Arg Val Pro Thr Leu Leu Gln 
            340                 345                 350         


His Leu Ala Ser Met Asp Phe Ser Thr Val Val Ser Glu Glu Asp Leu 
        355                 360                 365             


Val Thr Lys Leu Asn Ala Gly Leu Gln Ala Ala Ser Glu Asp Pro Arg 
    370                 375                 380                 


Leu Leu Val Arg Ala Ile Gly Pro Thr Glu Thr Pro Ser Trp Pro Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Ala Glu Asp Ser Pro Gly Val Ala Pro Glu Leu Pro 
                405                 410                 415     


Glu Asp Glu Ala Ile Arg Gln Ala Leu Val Asp Ser Val Phe Gln Val 
            420                 425                 430         


Ser Val Leu Pro Gly Asn Val Gly Tyr Leu Arg Phe Asp Ser Phe Ala 
        435                 440                 445             


Asp Ala Ser Val Leu Gly Val Leu Ala Pro Tyr Val Leu Arg Gln Val 
    450                 455                 460                 


Trp Glu Pro Leu Gln Asp Thr Glu His Leu Ile Met Asp Leu Arg His 
465                 470                 475                 480 


Asn Pro Gly Gly Pro Ser Ser Ala Val Pro Leu Leu Leu Ser Tyr Phe 
                485                 490                 495     


Gln Gly Pro Glu Ala Gly Pro Val His Leu Phe Thr Thr Tyr Asp Arg 
            500                 505                 510         


Arg Thr Asn Ile Thr Gln Glu His Phe Ser His Met Glu Leu Pro Gly 
        515                 520                 525             


Pro Arg Tyr Ser Thr Gln Arg Gly Val Tyr Leu Leu Thr Ser His Arg 
    530                 535                 540                 


Thr Ala Thr Ala Ala Glu Glu Phe Ala Phe Leu Met Gln Ser Leu Gly 
545                 550                 555                 560 


Trp Ala Thr Leu Val Gly Glu Ile Thr Ala Gly Asn Leu Leu His Thr 
                565                 570                 575     


Arg Thr Val Pro Leu Leu Asp Thr Pro Glu Gly Ser Leu Ala Leu Thr 
            580                 585                 590         


Val Pro Val Leu Thr Phe Ile Asp Asn His Gly Glu Ala Trp Leu Gly 
        595                 600                 605             


Gly Gly Val Val Pro Asp Ala Ile Val Leu Ala Glu Glu Ala Leu Asp 
    610                 615                 620                 


Lys Ala Gln Glu Val Leu Glu Phe His Gln Ser Leu Gly Ala Leu Val 
625                 630                 635                 640 


Glu Gly Thr Gly His Leu Leu Glu Ala His Tyr Ala Arg Pro Glu Val 
                645                 650                 655     


Val Gly Gln Thr Ser Ala Leu Leu Arg Ala Lys Leu Ala Gln Gly Ala 
            660                 665                 670         


Tyr Arg Thr Ala Val Asp Leu Glu Ser Leu Ala Ser Gln Leu Thr Ala 
        675                 680                 685             


Asp Leu Gln Glu Val Ser Gly Asp His Arg Leu Leu Val Phe His Ser 
    690                 695                 700                 


Pro Gly Glu Leu Val Val Glu Glu Ala Pro Pro Pro Pro Pro Ala Val 
705                 710                 715                 720 


Pro Ser Pro Glu Glu Leu Thr Tyr Leu Ile Glu Ala Leu Phe Lys Thr 
                725                 730                 735     


Glu Val Leu Pro Gly Gln Leu Gly Tyr Leu Arg Phe Asp Ala Met Ala 
            740                 745                 750         


Glu Leu Glu Thr Val Lys Ala Val Gly Pro Gln Leu Val Arg Leu Val 
        755                 760                 765             


Trp Gln Gln Leu Val Asp Thr Ala Ala Leu Val Ile Asp Leu Arg Tyr 
    770                 775                 780                 


Asn Pro Gly Ser Tyr Ser Thr Ala Ile Pro Leu Leu Cys Ser Tyr Phe 
785                 790                 795                 800 


Phe Glu Ala Glu Pro Arg Gln His Leu Tyr Ser Val Phe Asp Arg Ala 
                805                 810                 815     


Thr Ser Lys Val Thr Glu Val Trp Thr Leu Pro Gln Val Ala Gly Gln 
            820                 825                 830         


Arg Tyr Gly Ser His Lys Asp Leu Tyr Ile Leu Met Ser His Thr Ser 
        835                 840                 845             


Gly Ser Ala Ala Glu Ala Phe Ala His Thr Met Gln Asp Leu Gln Arg 
    850                 855                 860                 


Ala Thr Val Ile Gly Glu Pro Thr Ala Gly Gly Ala Leu Ser Val Gly 
865                 870                 875                 880 


Ile Tyr Gln Val Gly Ser Ser Pro Leu Tyr Ala Ser Met Pro Thr Gln 
                885                 890                 895     


Met Ala Met Ser Ala Thr Thr Gly Lys Ala Trp Asp Leu Ala Gly Val 
            900                 905                 910         


Glu Pro Asp Ile Thr Val Pro Met Ser Glu Ala Leu Ser Ile Ala Gln 
        915                 920                 925             


Asp Ile Val Ala Leu Arg Ala Lys Val Pro Thr Val Leu Gln Thr Ala 
    930                 935                 940                 


Gly Lys Leu Val Ala Asp Asn Tyr Ala Ser Ala Glu Leu Gly Ala Lys 
945                 950                 955                 960 


Met Ala Thr Lys Leu Ser Gly Leu Gln Ser Arg Tyr Ser Arg Val Thr 
                965                 970                 975     


Ser Glu Val Ala Leu Ala Glu Ile Leu Gly Ala Asp Leu Gln Met Leu 
            980                 985                 990         


Ser Gly Asp Pro His Leu Lys Ala  Ala His Ile Pro Glu  Asn Ala Lys 
        995                 1000                 1005             


Asp Arg  Ile Pro Gly Ile Val  Pro Met Gln Ile Pro  Ser Pro Glu 
    1010                 1015                 1020             


Val Phe  Glu Glu Leu Ile Lys  Phe Ser Phe His Thr  Asn Val Leu 
    1025                 1030                 1035             


Glu Asp  Asn Ile Gly Tyr Leu  Arg Phe Asp Met Phe  Gly Asp Gly 
    1040                 1045                 1050             


Glu Leu  Leu Thr Gln Val Ser  Arg Leu Leu Val Glu  His Ile Trp 
    1055                 1060                 1065             


Lys Lys  Ile Met His Thr Asp  Ala Met Ile Ile Asp  Met Arg Phe 
    1070                 1075                 1080             


Asn Ile  Gly Gly Pro Thr Ser  Ser Ile Pro Ile Leu  Cys Ser Tyr 
    1085                 1090                 1095             


Phe Phe  Asp Glu Gly Pro Pro  Val Leu Leu Asp Lys  Ile Tyr Ser 
    1100                 1105                 1110             


Arg Pro  Asp Asp Ser Val Ser  Glu Leu Trp Thr His  Ala Gln Val 
    1115                 1120                 1125             


Val Gly  Glu Arg Tyr Gly Ser  Lys Lys Ser Met Val  Ile Leu Thr 
    1130                 1135                 1140             


Ser Ser  Val Thr Ala Gly Thr  Ala Glu Glu Phe Thr  Tyr Ile Met 
    1145                 1150                 1155             


Lys Arg  Leu Gly Arg Ala Leu  Val Ile Gly Glu Val  Thr Ser Gly 
    1160                 1165                 1170             


Gly Cys  Gln Pro Pro Gln Thr  Tyr His Val Asp Asp  Thr Asn Leu 
    1175                 1180                 1185             


Tyr Leu  Thr Ile Pro Thr Ala  Arg Ser Val Gly Ala  Ser Asp Gly 
    1190                 1195                 1200             


Ser Ser  Trp Glu Gly Val Gly  Val Thr Pro His Val  Val Val Pro 
    1205                 1210                 1215             


Ala Glu  Glu Ala Leu Ala Arg  Ala Lys Glu Met Leu  Gln His Asn 
    1220                 1225                 1230             


Gln Leu  Arg Val Lys Arg Ser  Pro Gly Leu Gln Asp  His Leu 
    1235                 1240                 1245         


<210>  54
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro 
1               5                   10                  15      


Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro 
            20                  25                  30          


Phe 
    


<210>  55
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro 
1               5                   10                  15      


Glu Leu Pro Tyr Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln Pro 
            20                  25                  30          


Phe 
    


<210>  56
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Gln Tyr Pro Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn 
1               5                   10                  15      


Pro Gln 
        


<210>  57
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Pro Trp 
1               5                   10          


<210>  58
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro 
1               5                   10                  15  


<210>  59
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Cys Arg Gly Gly Gly Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln 
1               5                   10                  15      


Pro Tyr 
        


<210>  60
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Cys Arg Gly Gly Gly Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln 
1               5                   10                  15      


Pro Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro 
            20                  25                  30          


Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro 
        35                  40                  45              


Gln Pro Phe 
    50      


<210>  61
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Cys Arg Gly Gly Gly Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln 
1               5                   10                  15      


Pro Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro 
            20                  25                  30          


Gln Pro Glu Leu Pro Tyr Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro 
        35                  40                  45              


Gln Pro Phe 
    50      


<210>  62
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


